RICH G. CARTER
Assistant Professor of Chemistry
Gilbert Hall, Room 301
Oregon State University
Corvallis, OR 97331
Tel: (541) 737-9486
Fax: (541) 737-9496
E-mail: rich.carter@oregonstate.edu
Web Site: http://www.onid.orst.edu/~carteric/index.html
RESEARCH INTERESTS
TOTAL SYNTHESIS OF BIOLOGICALLY ACTIVE COMPLEX NATURAL PRODUCTS.
• Synthetic efforts toward the total synthesis of azaspiracid, a recently isolated
complex spirotoxin.
• Synthetic efforts toward the total synthesis of amphidinolide B1, a recently
isolated cytotoxic macrolide.
• Synthetic efforts toward the total synthesis of vacidin A, a promising treatment
for life-threatening infections.
TARGET-ORIENTED STRATEGIES FOR SOLUTION TO CURRENT SYNTHETIC PROBLEMS.
• Development of the first catalytic, asymmetric method for oxidation of prochiral
selenides with in situ [2,3] sigmatropic rearrangement.
• Development of a tandem reaction strategies for the construction for complex
diene systems.
PROFESSIONAL PREPARATION
September 1997
NATIONAL INSTITUTES OF HEALTH POSTDOCTORAL
to June 1999
FELLOW, OREGON STATE UNIVERSITY; Professor James D.
White, Supervisor.
May 1997
UNIVERSITY OF TEXAS AT AUSTIN, PH.D. IN ORGANIC
CHEMISTRY; Professor Philip D. Magnus, Supervisor.
May 1993
GETTYSBURG COLLEGE, B.S. IN CHEMISTRY.
APPOINTMENTS
May 2002
to Current
January 2002
to May 2002
August 1999
to May 2002
ASSISTANT PROFESSOR OF CHEMISTRY, OREGON STATE
UNIVERSITY, CORVALLIS, OR.
ADJUNCT ASSISTANT PROFESSOR OF MEDICINAL
CHEMISTRY, UNIVERSITY OF MISSISSIPPI, OXFORD, M
ASSISTANT PROFESSOR OF CHEMISTRY, UNIVERSITY OF
MISSISSIPPI, OXFORD, MS.
PUBLICATIONS
Magnus, P.; Carter, R.; Davies, M.; Elliott, J.; Pitterna, T. "Studies on the
Synthesis of the Core Structures of the Antitumor Agents Neocarzinostatin, Kedarcidin,
C-1027, and Maduropeptin." Tetrahedron 1996, 52, 6283-306.
White, J. D.; Carter, R. G.; Sundermann, K. F. "A Highly Stereoselective
Synthesis of Epothilone B." J. Org. Chem. 1999, 64, 684-85.
White, J. D.; Sundermann, K. F.; Carter, R. G. "Improved Synthesis of Epothilone
B Employing Alkylation of an Alkyne for Assembly of Subunits." Org. Lett. 1999, 1,
1431-34.
Carter, R.; Magnus, P.; Hodgetts, K.; McKenna, J.; Mitchell, I.; Wren., S.
"Studies on the Stereoselective Synthesis of the Marine Antitumor Agent Eleutherobin."
Tetrahedron 2000, 56, 4367-82.
Carter, R. G.; Weldon, D. J. "Studies Directed Toward the Total Synthesis of
Azaspiracid: Stereoselective Construction of C1-C12, C13-C19 and C21-C25 Fragments."
Org. Lett. 2000, 2, 3913-16.
Carter, R. G.; Bourland, T. C. " The first vanadium-catalyzed oxidation of aryl
allylic selenides with in situ [2,3] sigmatropic rearrangement." J. Chem. Soc., Chem.
Commun. 2000, 2031-32.
White, J. D.; Carter, R. G.; Sundermann, K. F.; Wartmann, M. "Total Synthesis of
Epothilone B, Epothilone D, and Cis and Trans 9,10-Dehydroepothilone D." J. Am.
Chem. Soc. 2001, 123, 5407-13.
Carter, R. G.; Graves, D. E. "Studies directed toward the total synthesis of
azaspiracid. Construction of the C1-C19 carbon backbone and synthesis of the C10, C13
nonnatural transoidal bisspirocyclic ring system." Tetrahedron Lett. 2001, 42 , 6035-39.
White, J. D.; Carter, R. G. "Silyl Ethers." in Science of Synthesis, Ian Fleming,
Ed., Thieme Publishing: Stuttgart, 2002, pp. 371-412.
Carter, R. G.; Bourland, T. C.; Graves, D. E. "1. Synthesis of ABC Ring System
of Azaspiracid: Effect of D Ring Truncation on Bisspirocyclization." Org. Lett. 2002, 4,
2177-79. Note: Awarded “Hot Article” status.
Carter, R. G.; Graves, D. E.; Gronemeyer, M. A., Tschumper, G. S. "2. Synthesis
of ABC Ring System of Azaspiracid: A Systematic Study into the Effect of C16 and C17
Substitution on Bisspirocyclization." Org. Lett. 2002, 4, 2181-84. Note: Awarded “Hot
Article” status.
FINANCIAL SUPPORT
NIH R01 (GM 63723) Award Entitled "Tandem Reactions in Organic Synthesis:
Proposed Total Syntheses of Azaspiracid and Amphidinolide B1." (June 1, 2002 - May
31, 2007).
HONORS
• Hot Article Status (2 papers) from Organic Letters, 2002.
• National Institutes of Health (NIH) Postdoctoral Fellow, 1998.
• David Burton Jr. Fellowship Award, 1996.
• Phi Beta Kappa Inductee, 1993.
• John B. Zinn Chemistry Research Award, 1993.
• Southeastern Pennsylvania Section of the American Chemical Society Outstanding
Senior Chemistry Major of Gettysburg College, 1993.
• Stine Chemistry Prize, 1993.
• Esther Brandt Chemistry Award, 1992.
• Glenn S. Weiland Summer Research Scholarship, 1992.
PRESENTATIONS
204th American Chemical Society National Meeting, San Diego, CA. D. L.
Jameson, R. G. Carter, M. D. Borden, E. P. Neuffer. "Synthesis and Coordination
Chemistry of New Chiral Polypyridine Ligands." Abstract # INORG-361.
216th American Chemical Society National Meeting, Boston, MA. J. D. White, R.
G. Carter, K. Sundermann "Synthetic Approach Towards the Total Synthesis of
Epothilone B." Abstract # ORG-41.
2000 Joint Southeast-Southwest Regional American Chemical Society Meeting,
New Orleans, LA. R. G. Carter, T. C. Bourland. "Studies Directed Towards the
Vanadium-Catalyzed, Asymmetric Oxidation of Aryl, Allylic Selenides with in situ [2,3]
Sigmatropic Rearrangement." Abstract # 522.
2000 Joint Southeast-Southwest Regional American Chemical Society Meeting,
New Orleans, LA. D. J. Weldon, R. G. Carter. "Studies Directed toward the Total
Synthesis of Azaspiracid." Abstract # 320.
221st American Chemical Society National Meeting, San Diego, CA. R. G. Carter,
D. J. Weldon, T. C. Bourland. "Synthetic studies toward the total synthesis of
Azaspiracid." Abstract # ORG-479.
2002 Gordon Research Conference on Natural Products, Tilton, NH. R. G.
Carter, T. C. Bourland, M. A. Gronemeyer. "Progress toward the Total Synthesis of the
Spirotoxin Azaspiracid." (Short Talk).
INVITED SEMINARS
Department of Chemistry, Colorado College (Colorado Springs, CO), "Total
Synthesis of Epothilone B." November 2000.
Department of Medicinal Chemistry, University of Mississippi (University, MS),
"Synthetic Studies toward the Spirotoxin Azaspiracid." November 2001.
Department of Chemistry, University of Memphis (Memphis, TN), "Synthetic
Studies toward the Spirotoxin Azaspiracid." November 2001
Department of Chemistry, Florida State University (Tallahassee, FL), "Synthetic
Studies toward the Spirotoxin Azaspiracid." November 2001
Department of Chemistry, Mississippi State University (Mississippi State, MS),
"Synthetic Studies toward the Spirotoxin Azaspiracid.” February 2002
PROFESSIONAL SOCIETIES
• Phi Beta Kappa, 1993.
• American Chemical Society, 1993.