Haythem Saadeh, PhD
Addresses
The University of Jordan
Faculty of Science.
The Department of Chemistry
Amman 11942 Jordan
Tel. ..962-6-5355000 ext. 22159
Fax 962-6 -5348932
Email: h.saadeh@ju.edu.jo
Jordan-Amman
Tel. 962 6 4390434
Mob. 962 77 7787366
Email: h.saadeh@ju.edu.jo
Biography
Date of Birth: July 15, 1966
Place of Birth: Amman, Jordan
Citizenship: Jordanian
Education
09/2004- current
Assistant Professor at the University of Jordan
09/2003- 09/2003
Lecturer at the Hashemite University
04/2000- 06/2003
Senior chemist at Transphotonics L.L.C.
10/94-03/2000
Ph.D. candidate in organic and polymeric chemistry.
The University of Chicago.
Advisor: Professor Luping Yu.
09/91-4/94
Ph.D. candidate in organic and
medicinal chemistry. Loyola University of Chicago.
Advisor: Professor Charles Thompson.
01/88-05/90
M.Sc. in organic chemistry. The
University of Jordan. Amman,Jordan.
09/84-12/87
B.Sc. in chemistry. Yarmouk
University, Irbid, Jordan.
1
Research Experience
9/2003-current: My research interest cover the following topics: the design and synthesis of new
NLO optical materials based on mixed valence complexes. The optical nolinearity of these novel
materials will be evaluated. These systems can be easily modified to and further investigate their
potential electroluminescence properties. The design and synthesis of novel piso-electric polymers and
photogalvanic nanomaterials. The design and synthesis of novel pyridine based-chelating polymers and
investigate their chelating properties with various metals. The design and synthesis of new heterocyclic
systems with a potential antimicrobial activity.
4/2000-6/2003: Senior Chemist at Trans Photonics.
In this company I was encharged with the design and synthesis of all projects involved.
1. Design and synthesis of novel Nonlinear Optical (NLO) polymers bearing a new class of NLO
chromophores. Studying the performance of these NLO polymers in optical data storage and
optical switching. In this project, NLO chromophores with a wide range of Uv-visible absorption
were synthesized; colorless chromophores (320 nm) to red chromophores (600 nm).
2. Design and synthesis of near Infrared organic light emitting diodes (IR-OLED’s). Various
stillbene-based chromophores were synthesized and the electroluminescent emissions were finetuned by structural modefication. This was easily achieved by changing the conjunction length
and the end groups. The electroluminescence specra of these chromophores covers a range of
500 nm to 1000 nm.
3. Design and synthesis of organo-soluble polyimides as cladding layers.
These polyimide
claddings layers can be fabricated carefully to enhance the adhesion and make it incompatible
upon processing with active layer. Various cladding layers with controllable refractive index
(n0.005) were synthesized.
4. Synthesis and characterization of novel Water-Soluble polyimides. These polyimides were
designed to develop a new class of cladding with enhanced adhesion properties. These materials
would be friendly to both chemists and enviromentalists.
5. Design and synthesis of conducting cladding based on polyimides and polybenzoxazoles. These
systems were synthesized by incorporating a conductive moiety into the polymer structure to
enhance the its electrical conductivity. These systems were designed so that the optical
transperancy of the material is maintained.
6. Design and synthesis of silicon containing polyimides. These kinds of polyimides will be
susceptible to HF etching by virtue of the high concentrations of C-O-Si moieties. These
polymers will be capable of being functionalized with NLO chromophores, thereby lending
themselves to applications as active in electro-optic modulators and optical switches.
7. Design and synthesis of smart materials for sensing explosives, heavy metals such as lead (Pd)
and biomolecules such as anthrax.
5/1995-3/2000: Graduate Research Assistant ,Department of chemistry, The University of Chicago.
1. Synthesis of Functionalized Polyimides:
Design, synthesis, and characterization of novel polyimides functionalized with nonlinear optical
(NLO) chromophores, which exhibit a high thermal stability and large nonlinearity.
2. Polyesterimides:
Design, synthesis and characterization of novel polyesterimides bearing NLO chromophores with a
large optical nonlinearity. The approach involves a multiple step synthesis of new monomers.
2
3. Self-Assembled Supramolecular Materials:
Design and synthesis of novel NLO self assembled supramolecular materials based on hydrogen
bonding. Different monomers were synthesized and various NLO chromophores were incorporated.
These novel systems exhibited a large optical nonlinearity coefficients (r33 = 70 pm/V). This r33
value is one of the largest values reported.
4. Electroluminescent polymers for light-emitting diodes(LEDs):
Synthesis of light-emitting materials. Various conjugated polymers such as, Polyphenylenethiophene
and the novel polyphenylenefuran, were synthesized by utilizing the Stille coupling reaction. Their
luminescence properties, photochemical stability and quantum efficiency were studied in details.
5/1992-10/1994: Graduate Research Assistant ,Department of chemistry, Loyola University of Chicago.
1. Heterocyclic Compounds with Antiviral activity:
Design and synthesis of guanine analoges by replacing C=O group at C4 by O=S=O. These analoges
were expected to shot down the reproduction of viruses by irreversable binding to the reproduction
enzyme active sites.
2/1988-5/1990: Graduate Research Assistant ,Department of chemistry, University of Jordan.
1. Tetrazines from via 1,3-dipole cycloaddition:
Selected series of 6-substitutes 4-aryl-3-heteroaryl-1-methyl-1,2,3,4-tetrahydro-s-tetrazines were
synthesized via direct interaction between appropriate nitrile imine and methylhydrazones. Those
systems exhibite a ring-chain tautomerizm in solution. The extent of tautomerizm was investigated
by 1 HNMR and interpreted in terms of conjugative and electronic effects of substituents.
Special Techniques
Expertise in: synthetic organic chemistry; a wide range of simple and complicated carbocyclic and
heterocyclic systems (thiophene, pyrrol, furan, imidazole, pyridine, pyrimidine, indole, azepine,
oxatriazines, tetrazines,…..); air and light sensitive chemistry; Spin-coating and casting films;
Vaccume deposition of metal electrodes; sublimation; Film thickness measurements by a profile or
prizm coupler setup; Viscometry; Flourescence; NMR, IR, HPLC and GC.
Awards and Honors
1. Nominee for outstanding teaching award, Loyola University of Chicago.
2. Nominee for outstanding teaching award, The University of Chicago.
3. Jordanian Councile of Science and Technology award for outstanding graduate student,
University of Jordan.
Presentations: The 214th ACS national meeting, September 7-11, 1997, Las Vegas, Nevada. (Saadeh,
Haythem; Gharavi, Alireza; Yu, Dong; Yu, Luping “Polyimides with a Diazo Chromophore
Exhibiting High Thermal Stability and Large Electrooptic Coefficients” Book of Abstracts, 214th
ACS National Meeting, Las Vegas, NV, September 7-11, 1997, Poly-217).
Affiliation: Member of the American Chemical Society.
3
Supervised Graduate Students:
Ph.D.: Jihad S. Al-Hawadi-2008 (POLYCHLORINATEDTERPHENYLS (PCT)-SYNTHESIS
AND ENVIRONMENTAL ANALYSIS).
Ms: 1. Mervat S. Samour-2007 (SYNTHESIS AND PROPERTIES OF SOME NEW N-(4NITROIMIDAZOL-5-YL)-L-A-AMINO ACID, THEIR NEW HYDANTOINS/
THIOHYDANTOINS DERIVATIVES AND MODEL THIENOPYRIMIDINES).
2. Eman A. Abu- Shairah -2007(SYNTHESIS AND CHARACTERIZATION OF NEW
METRONIDAZOLE DERIVATIVES).
3. Ahmad T. Al-Masri-2008 (SYNTHESIS, CHARACTERIZATION, AND BIOLOGICAL
ACTIVITIES OF NEW COMPOUNDS DERIVED FROM METRONIDAZOLE AND AMINO ACIDS
AND THEIR ESTERS").
4. Eman A.Ahmad-2009 (COMPLEXATION AND STABILITY STUDY OF SUBEROYLANILIDE
HYDROXAMIC ACID).
Publications:
1.
El-Abadelah, M.; Hussein, A.; Saadeh, H. “Substituent Effect on Ring-Chain Tautomerizm of
1,2,3,4-Tetrahydro-s-tetrazines”, Heterocycles, 1991, 32, 1063.
2. Saadeh,
H.;
Thompson,
C.;
Fernandeze,
E.;
Pavkovic,
S.
“1-Benzyl-5Methoxycarbonylmethylthio-4-Nitroimidazole”, Acta Crystall. Sec. C-Crystal Structure
Comm. 1995, 51, 950.
3. Saadeh, H. Gharavi, A.; Yu, D.; Yu, L. “Polyimides with a Diazo Chromophore Exhibiting
High Thermal Stability and Large Electrooptic Coefficients”, Macromolecules, 1997, 30,
5403.
4. Saadeh, H. Gharavi, A.; Yu, D.; Yu, L. “Polyimides with a Diazo Chromophore Exhibiting
Large Electrooptic Coefficients”, Polymer Preprints, 1997, 38, 552.
5. Saadeh, H.; Goodson, T.; Yu, L. “Synthesis of a Polyphenylene-co-furan and Polyphenyleneco-thiophene and Comparison of Their Electroluminescent Properties”, Macromolecules,
1997, 30, 4608.
6. Abdul-Jawad, S.; Al-Najjar, A.; Bader, M. M.; Saadeh, H. A.; Yu, L. “AC Electrical Behavior
of A Novel Electro-optic Polyimide” Book of Abstracts, 213th ACS National Meeting, San
Francisco, April 13-17, 1997, PMSE-195.
7. Saadeh, H.; Yu, D.; Wang, L.; Yu, L. “Highly Stable, Functionalized Polyimides for Second
Order Nonlinear Optics”, J. Mater. Chem. 1999, 9, 1865.
8. Wang, L.; Ng, Man-Kit; Saadeh, H.; Yu, L. “ Photorefractive Properties of Molecules
Containing Oligothiophenes and a Nonlinear Optical Chromophore: The Influence of
Conjugation length”, Polymer Preprints, 1999, 40, 1250.
4
9. Qing, L.; Wang, L.; Saadeh, H.; Yu, L. “A New Family of Amorphous Molecular Materials
Showing Large Photorefractive Effect”, Chem. Comm. 1999, 1689.
10. Saadeh, H.; Wang, L.; Yu, L. “ A New Synthetic Approach to Novel Polymers Exhibiting
Large Electrooptic Coefficients and High Thermal Stability” Macromolecules, 2000, 33,
1570.
11. Saadeh, H.; Wang, L.; Yu, L “Supramolecular Solid State Assembly Exhibiting Electro-Optic
Effects”. J. Am. Chem. Soc. 2000, 122, 546.
12. Al-Noaimi, Mousa Z.; Saadeh, Haythem; Haddad, Salim F.; El-Barghouthi, Musa I.; El-Khateeb,
Mohammad; Crutchley, Robert J. Syntheses, crystallography and spectroelectrochemical
studies of ruthenium azomethine complexes. Polyhedron , 2007, 26(14), 3675-3685.
13. Salih, Kifah S. M.; Ayoub, Mikdad T.; Saadeh, Haythem A.; Al-Masoudi, Najim A.; Mubarak,
Mohammad S. Synthesis, characterization, and biological activities of new benzofuran
derivatives. Heterocycles , 2007, 71(7), 1577-1587.
14. Alshamaileh, Ehab; Alawi, Mahmoud; Dahdal, Yara; Saadeh, Haythem Kinetic Stability study
of Selected Hydroxamic Acids Using HPLC/UV. Jordan Journal of Pharmaceutical Sciences
2008, 1(1), 28-37.
15. Saadeh, Haythem A. ; Mosleh, Ibrahim M.; Mubarak, Mohammad S. Synthesis of Novel
Hybrid Molecules from Precursors With Known Antiparasitic Activity Molecules 2009, 14,
1483-1494.
16. Karapanagiotis, I.; Mantzouris, D.; Chryssoulakis , Y. Saadeh, H. A.; Alawi, M. A.; Mubarak,
M. S.; Karadag, R.; Yurdun, T.; AlSaad, Z.; Abdel-Kareem, O.; Puchinger, L.; Sauter, F.
Inter-Laboratory Chemical Study of Natural Materials from the Historical Wiesner
Collection. Jor. J. Chem. 2009, 4, 195-207.
17. Saadeh, Haythem A. ; Mosleh, Ibrahim M.; El-Abadelah, Mustafa M. New Synthesis and
Antiparasitic Activity of Model 5-Aryl-1-methyl-4-nitroimidazoles. Molecules 2009, 14,
2758-2767.
18. Saadeh, Haythem Ali; Al-Masri, Ahmed T.; Mosleh, Ibrahim M.; Mubarak, Mohammad S.
Synthesis, characterization, and biological activities of new compounds derived from
metronidazole and amino acids and their esters. Abstracts of Papers, 238th ACS National
Meeting, Washington, DC, United States, August 16-20, 2009 (2009).
19. Saadeh, Haythem Ali; Mosleh, Ibrahim M.; Al-Bakri, Amal G.; Mubarak, Mohammad S.
Synthesis and antimicrobial activity of new 1,2,4-triazole-3-thiole metronidazole derivatives.
Monatshefte Fur Chemie 2010, 141, 471-478.
20. Samer Al-Gharabli*, Nafisah Al-Rifai, Haythem A. Saadeh, Ibrahim M. Mosleh and Mohammad
S. Mubarak Solid Phase Synthesis and Antiparasitic Activity of a Library of Peptidyl
Metronidazoles Jor. J. Chem, 2010, 5(2), 139-147
5
21. Al-Noaimi, Mousa Z.; El-Khateeb, Mohammad; Haddad, Salim F; Saadeh, Haythem
Synthesis, X-ray structures, spectroscopic and electrochemical properties of ruthenium(II)
complexes containing 2,2'-bipyrdine and thiophenyl modified azomethine ligands.
(Submitted).
Patents:
1. Polyaryl azo dye chromophores and their optical use.
Saadeh, Haythem; Gharavi, Alireza.
PCT Int. Appl. (2002) WO 2002033005 A2 20020425.
2. Preparation of water-soluble polyimides. Gharavi, Alireza; Saadeh, Haythem U.S. 6894174
(2005).
3. Preparation of metronidazole derivatives as antiparasitic agents. Abu Shairah, Eman Ahmad
Mohammad; Saadeh, Haythem Ali Mohammad; Mosleh, Ibrahim Mousa Ibrahim; Al Arif, Mikidad
Tawfig Ayoub; Mubarak, Mohammad Suleiman. Eur. Pat. Appl. (2009), 19pp.
Ph.D Thesis:
“Design and Synthesis of Novel Materials Exhibiting Large Electrooptic Coefficients”. Saadeh,
Haythem Ali. The University of Chicago, USA. (2000), 204 pp.
6