Doctor`s Tri-Fold

sedimentation rate, or physician global
assessment), lasting for at least two months
after the treatment period.
Can Do More For Patients Who
Need More Naturally
SIXTY PERCENT of the patients showed
substantial clinical response and one patient
showed a complete response in which the
disease was totally eliminated for 26 months.
More importantly, there were absolutely no
side effects.
The Natural First choice for
Reduction of Inflammations, Body
Pains and Joints Discomfort
Medical research from Harvard
(USA) and Rostock (Germany)
Universities confirms that Collagen
supplementation reduces body pain
and inflammation associated with
muscles and joints naturally.
Collageena is one of the most
pleasant tasting forms of collagen
available today.
Collageena added to one's diet
increase the body’s ability to
regenerate collagen that is reduced
with age. The Collageena formula
has also shown good results in
curbing appetite, boosting energy
and endurance, as well as
improving skin and muscle tone.
All patients were evaluated. Twenty-eight had
received the collagen type II and 31 had
received the placebo.
Compared to the placebo group, the collagen
improvements in joint swelling, tenderness
or pain.
Harvard University School of Medicine
At Harvard University School of Medicine, Dr.
David Trentham and his colleagues gave very
small doses of solubilized collagen type II to 10
patients with rheumatoid arthritis. These
patients had all immunosuppressive drugs and
anti-inflammatories such as methotrexate and
mercaptopurine removed before they took the
collagen type II.
Patients took
small doses of collagen type II for one month
and then increased the dosage for two months
thereafter. The dosage was determined through
the various animal studies that had determined
specific concentrations.
clinical response was defined as a 50% or
greater improvement in the number of swollen
and tender joints, accompanied by a 50% or
greater improvement in two additional
measures (morning stiffness, 15 meter walking
time, grip strength, Westergren erythrocyte
This also included the degree of swelling and
tenderness together. The doctors evaluated the
response in a 15 meter walking time at months
one, two and three. During the period at which
the patients were taken off
Four patients in the collagen type II group
went into the next realm of the almost
unbelievable, and showed a complete
resolution of the disease.
The Harvard Study was sponsored by Autoimmune, a Lexington, Massachusetts
biotechnology company. Only highly purified chicken sternal collagen type II was
This report from the book entitled "The Collagen Type II Cure for Arthritis
and Heart Disease", by Alex Duarte, O.D., Ph.D. Published October 1997,
ISBN # 1-891036-11-4
The Effects of Collagen Hydrolysat on
Symptoms of Chronic Fibromyalgia and
Joint Pain
Gary B. Olson, D.D.S.; Sue Savage. M.B.S. JoAnn
Olson, R.P.P.
ABSTRACT: Twenty (20) people who had
medically diagnosed fibromyalgia for two to
15+ years participated in and completed a 90-day
evaluation to determine effects of
collagen hydrolysat on symptoms of chronic
fibromyalgia, with twelve reporting
temporomandibular joint pain. Participants were
evaluated initially and then at 30-, 60-, and 90-day
periods. Final results were obtained and
comparisons made. The average pain complaint
levels decreased significantly in an overall group
average, and dramatically with some individuals. It
was concluded that patients with fibromyalgia and
concurrent temporomandibular joint problems may
gain symptomatic improvement in their chronic
symptoms by taking collagen.
The total without a response of less pain in forty-five days was three or appox.
10.1% and only one placebo subject recorded a response in forty-five days.
Side effects - Only one subject had nausea. It was noted that he was on other
medications as well.
Collagen Type II treatment had a significant
effect on subjective pain syndromes. Most
subjects responded to Collagen Type II in the
first 21 days of the trial. Many of these pained
subjects had previously been on long-term,
pharmaceutical treatment programs. Many
subjects responded by initiating life style
changes due to lack of pain. Many were excited
by the increase in their daily activity. The
results have prompted the authors to develop
specific disease/pain syndrome trials in the near
The Journal of Cranomandibular Practice April 2000, vol 18, no 2.
Clinical studies show: Hydrolyzed Collagen
can relieve osteoarthritic pain
The first well-founded studies were carried out
during the 1980s [1; 2; 3 etc.].
Already in 1991, we published data from our own
randomized, double-blind study on 81 patients
suffering from osteoarthritis [4].
Rippe et al. show: Hydrolyzed collagen
influences isokinetic power
The results of a double-blind, randomized,
prospective and placebo-controlled study carried out
by James Rippe and colleagues (Massachusetts,
USA) on 190 patients with confirmed osteoarthritis
of the knee are of high importance, too [9]
Clinical studies demonstrate: Hydrolyzed
collagen can improve mobility and reduce
the requirement for analgesics
BEUKER and ROSENFELD [7] in a 6-month
placebo-controlled study on 100 elderly patients
(average age 62) also established a distinct
therapeutic effect.
■ There are no medical application
restrictions on hydrolyzed collagen
Hydrolyzed collagen, a protein prepared by
hydrolysis and which is contained in high
proportions in foodstuffs of animal origin is highly
tolerated and without side-effects. TAKEDA [11]
■ Collagen is well digested and absorbed[12]
■ Hydrolyzed collagen has an effect on other
collagen-rich vital tissues
In veterinary medicine, the highly significant
improvement in the properties of hair and hooves
brought about by hydrolyzed collagen has been
known for many years (e.g. MORGANTI [15];
■ Hydrolyzed collagen causes no serious
intolerance reactions [8]
1. Krug E.; Acta Medica Empirica 28: 1-23; 1979
2. Götz B.; Ärztliche Praxis 34: 3130-34; 1982
3. Oberschelp U., Seeligmüller K. et al.; Therapiewoche 39: 3153-57;
4. Adam, M.; “Welche Wirkung haben Gelatinepräparate?” in:
41: 2456-61; 1991
5. Seeligmüller K. et. al.; Therapiewoche 39: 3153-57; 1989
6. Seeligmüller K. et al.; Therapiewoche 4: 1810-13; 1993
7. Beuker F. et al; Int J Sportsmed 1: 1-88 ; 1996
8. Moskowitz R.; Semin Arthritis Rheum 30: 87-99; 2000
9. Rippe, J.; Efficacy of Knox Nutrajoint™ on indices of joint health,
activity and quality of life in patients with mild osteoarthritis of the
Publikation zur Veröffentlichung eingereicht
10. Gromnica-Ihle E. zu BRANDT K.; “Arthrosen” in: HARRISON,
Medizin, 15. Auflage/Deutsche Ausgabe, abw-Wissenschaftsverlag
2182; 2003
11. Takeda U. et al.; J Toxicol Sci 7, Suppl.2: 53-91; 1982
12. Oesser S. et al; Am J Nutr 129: 1891-95; 1999
15. Morganti P.; Bolletino della Sicieta Italiana die Biologi
sperimentale; 1983
16. Brodie J.; Appl. Cometol. 2: 15ff.; 1984
17. Weh L.; 2001; Changes in the properties of tissue through the
of gelatine: extracta orthopaedica 4/2001: 12-16
18. Khouri A. et al.; 1992; zitiert bei 17.