Growth comparative studies on the effect of salt stress on Chlorella vulgaris and Chlorella salina Shaddad, M. A. K.1, Galal, H.R.M., Fargal, M.A.A. and Elwaleed, E. A. Department of Botany Sciences, Faculty of science, south valley University, Qena, Egypt. Email- EME_BIOLOGIST@yahoo.com ABSTRACT The objective of this study was to investigate the effects of NaCl stress on Fresh, dry weight, optical density, cell number, contents of photosynthetic pigments, Oevolution, O-uptake and some minerals of two unicellular micro green fresh algae (Chlorella vulgaris) and marine algae (Chlorella salina). Our data recommended that the growth criteria in Chlorella salina become more than 2-fold at 1M NaCl, while the growth criteria of Chlorella vulgaris dropped progressively at 800 mM NaCl, additionally while Chlorella vulgaris killed beyond 800mM NaCl Chlorella salina can survive with any deleterious effect. As noted in the report chlorella salina grew well in a broad range of salinity, thus, the organisms investigated showed a wide range of salinity tolerance. However, the researcher also found a possible reason for organisms showing resistance to salinity levels may be due to the organism being osmotically adaptive to the environment. However, this trend was only noted in water with a salinity less than full strength seawater. Finally, the report suggests and describes that salinity is an important factor in controlling the distribution of organisms. Key words: fresh algae; marine algae; Chlorella; Salinity.