MATERIAL SAFETY DATA SHEET Section 1. Product and Company Information Product Name: Ultrapure 3-Hydroxypicolinic Acid (3-HPA) MALDI Matrix Catalog Numbers: CMS-105 UN Number: Harmonized Code: Revision Date: Not applicable 2933399090 03/23/2009 Section 2. Composition / Information on Components Chemical Characterization Description: Mixture of the substances below with non-hazardous additions. Listing of dangerous and non-hazardous components: CAS # Chemical Name 874-24-8 Section 3. 3-Hydroxy-picolinic acid EC # Percent 212-859-0 83% Hazards Identification Appearance: yellowish powder. Warning! Causes eye, skin, and respiratory tract irritation. The toxicological properties of this material have not been fully investigated. Target Organs: No data found. Potential Health Effects The small amounts in our kits are unlikely to cause severe or immediate health effects. The chemical 3hydroxy-picolinic acid has to be used as directed, in accordance to safe laboratory practices, as it can be irritating to eyes, respiratory system and skin. Section 4. First Aid Measures Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Ingestion: Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation. Notes to Physician: Treat symptomatically and supportively. Section 5. Fire Fighting Measures General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing Media: Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam. Flash Point: Not applicable. Autoignition Temperature: Not applicable. Explosion Limits, Lower:Not available. Upper: Not available. NFPA Rating: (estimated) Health: 2; Flammability: 0; Instability: 0 Section 6. Accidental Release Measures General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation. Section 7. Handling and Storage Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Section 8. Exposure Control / Personal Protection Handle in accordance with good laboratory practices. Respiratory Protection: Not normally needed. If exposure limits are exceeded, use approved particulate respirator. Eye Protection: Safety glasses with side shields. Skin Protection: Wear protective gloves. Disposable nitrile gloves are acceptable for light, intermittent exposure. Engineering Controls: No special requirements. Handle in an area with good general room ventilation. Section 9. Physical and Chemical Properties Appearance: Yellowish crystals Physical State: Solid Flash Point: NA Vapor Pressure: NA Odor: None Explosion Limits: NA Vapor Density (air=1): NA pH: NA Boiling Point: NA Solubility in Water: NE Specific Gravity: NA Melting Point: 218° C Section 10. Stability and Reactivity Hazardous Polymerization: Will Not Occur May Occur Stability: Stable Hazardous Decomposition/Combustion Products: Conditions & Materials to Avoid: Nitrogen Oxides, Carbon monoxide, Carbon dioxide, strong oxidizing agents, and strong bases. Section 11. Toxicological Information Primary Route(s) of Exposure Under Normal Use: Inhalation Target Organ(s): NE Acute Effects: May be irritating to skin, eyes and respiratory system. Chronic Effects: NE Other Information: Chemical Ingredient(s) not classified as carcinogen(s) by OSHA, IARC, NTP, ACGIH, or California. Section 12. Ecological Information Environmental Fate: When released into water, this material may biodegrade to a moderate extent. This material is not expected to significantly bioaccumulate. Environmental Toxicity: No information found Section 13. Disposal Considerations Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification. RCRA P-Series: None listed. RCRA U-Series: None listed. Section 14. Transport Information Non Hazardous for Transport. Not Regulated U.S. DOT: Shipping Name: NE TDG: NE Hazard Class: NE UN/NA #: NE IATA/ICAO: NE Packing Group #: NE Section 15. Regulatory Information EU Risk & Safety Phrases: NE U.S. TOSCA: R&D Exemption: For laboratory use only. Use only in small quantities, solely for purposes of scientific experimentation, analysis, research or development. Canada: This product has been classified according to the hazard criteria of the CPR and this MSDS contains all the information required by the CPR. Chemical Weapons Convention: No TSCA 12(b): No CDTA: No SARA 311/312: Acute: Yes Chronic: No Fire: No Pressure: No Reactivity: No (Pure / Solid) Australian Hazchem Code: None allocated. Poison Schedule: None allocated. WHMIS: This MSDS has been prepared according to the hazard criteria of the Controlled Products Regulations (CPR) and the MSDS contains all of the information required by the CPR. Section 16. Other Information MSDS Creation Date: 01/02/2009 Revision #1 Date: 03/23/2009 The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall Protea Biosciences be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Protea Biosciences has been advised of the possibility of such damages.