Jürgen Rohr, Ph.D.
Publications (1985-2012; August 2012)
1)
P. G. Jones*, G. M. Sheldrick, J. Rohr and A. Zeeck*: Elloramycin, C32H36O15. Acta
Cryst. 1985, C41, 255-257.
2)
H. Drautz, P. Reuschenbach, H. Zähner, J. Rohr and A. Zeeck*: Metabolic Products of
Microorganism. 225. Elloramycin, a New Anthracycline-like Antibiotic from Streptomyces olivaceus. Isolation, Characterization, Structure and Biological Properties. J.
Antibiot. 1985, 38, 1291-1301.
3)
H. P. Fiedler, J. Rohr and A. Zeeck*: Elloramycins B, C, D, E and F: Minor Congeners
of the Elloramycin Producer Streptomyces olivaceus. J. Antibiot. 1986, 39, 856-859.
4)
A. Zeeck, J. Rohr, G. M. Sheldrick*, P. G. Jones and E. F. Paulus: Structure of a New
Antibiotic and Cytotoxic Indicator Substance, Urdamycin A. J. Chem. Res. (S) 1986,
104-105.
5)
H. Drautz, H. Zähner, J. Rohr and A. Zeeck*: Metabolic Products of Microorganisms.
234. Urdamycins, New Angucycline Antibiotics from Streptomyces fradiae. I. Isolation,
Characterization and Biological Properties. J. Antibiot. 1986, 39, 1657-1669.
6)
J. Rohr and A. Zeeck: Metabolic Products of Microorganisms. 240. Urdamycins, New
Angucycline Antibiotics from Streptomyces fradiae. II. Structural Studies of Urdamycins B to F. J. Antibiot. 1987, 40, 459-467.
7)
J. Rohr*, A. Zeeck and H. G. Floss*: Urdamycins, New Angucycline Antibiotics from
Streptomyces fradiae. III. The Structures of Urdamycins C and D. J. Antibiot. 1988 41,
126-129.
8)
J. Rohr und A. Zeeck: Biogenetisch-chemische Klassifizierung fermentativ hergestellter
Sekundärstoffe. Jahrbuch Biotechnologie 1988/89, Carl Hanser Verlag, München, S.
263-295, 1988.
J. Rohr and A. Zeeck: Biogenetic-chemical Classification of Secondary Metabolites by
Fermentation. In: Biotechnology Focus 2, Edt. R.K.Finn and P.Präve, Hanser Publishers, Munich, Vienna, New York, p. 251-283, 1990.
9)
J. Rohr*, S. Eick, A. Zeeck, P. Reuschenbach, H. Zähner and H. P. Fiedler*: Metabolic
Products of Microorganisms. 249. Tetracenomycins B3 and D3, Key Intermediates of the
Elloramycin and Tetracenomycin C Biosynthesis. J. Antibiot. 1988, 41, 1066-1073.
10)
J. Rohr*, J. M. Beale and H. G. Floss*: Urdamycins, New Angucycline Antibiotics from
Streptomyces fradiae. IV. Biosynthetic Studies of Urdamycins A-D. J. Antibiot. 1989,
42, 1151-1157.
11)
T. Henkel, T. Ciesiolka, J. Rohr and A. Zeeck*: Urdamycins, New Angucycline Antibiotics from Streptomyces fradiae. V. Derivatives of Urdamycin A. J. Antibiot. 1989,
42, 299-311.
12)
J. Rohr: Biosynthetic Formation of the S-Methyl Group of the Angucycline Antibiotic
Urdamycin E. J. Chem. Soc. Chem. Commun. 1989, 492-493.
13)
J. Rohr: Urdamycins, New Angucycline Antibiotics from Streptomyces fradiae. VI.
Structure Elucidation and Biosynthetic Investigations on Urdamycin H. J. Antibiot.
1989, 42, 1482-1488.
14)
J. Rohr: A Novel Type of Non-Enzymatic Reaction during the Late Steps in the Biosynthesis of the Angucycline Antibiotics Urdamycins C and D. J. Chem. Soc., Chem. Commun. 1990, 113-114.
15)
T. Henkel, J. Rohr*, J. M. Beale and L. Schwenen: Landomycins, New Angucycline
Antibiotics from Streptomyces sp. I. Structural Studies on Landomycins A-D. J.
Antibiot. 1990, 43, 492-503.
16)
J. Rohr und A. Zeeck: Niedermolekulare Naturstoffe - Jahresrückblick Organische
Chemie 1989, Nachr. Chem. Techn. Lab. 1990, 38, 156-162.
17)
J. Rohr: A Novel Type of Ring Contraction as Non-Enzymatic Step in the Later Stages
of the Biosynthesis of Urdamycin H. Angew. Chem. Int. Ed. Engl. 1990, 29, 1051-1053.
18)
J. Rohr and A. Zeeck*: Structure-Activity-Relationships of Elloramycin and Tetracenomycin C. J. Antibiot. 1990, 43, 1169-1178.
19)
M. Schönewolf, S. Grabley, K. Hütter, R. Machinek, J. Wink, A. Zeeck and J. Rohr*:
Secondary Metabolites by Chemical Screening. Glycerinopyrin, a Novel Metabolite
from Streptomyces violaceus. Liebigs Ann. Chem. 1991, 77-80.
20)
M. Schönewolf and J. Rohr*: Biogenesis of The Carbon Skeleton of Glycerinopyrin: A
New Biosynthetic Pathway for Pyrroles. Angew. Chem. Int. Ed. Engl. 1991, 30, 183185.
21)
G. Udvarnoki, T. Henkel, R. Machinek, and J. Rohr*: The Biosynthetic Origin of the
Oxygen Atoms of Aquayamycin - Aspects for the Biosynthesis of the Urdamycin
Family and for Aquayamycin-Containing Angucycline Antibiotics in General. J. Org.
Chem. 1992, 57, 1274-1276.
22)
J. Rohr* and R. Thiericke: Angucycline Group Antibiotics. Nat. Prod. Rep. 1992, 9,
103-137.
23)
M. Schönewolf und J. Rohr*: Biosynthesewege zu Pyrrolen. GIT Fachz. Lab. 1992, 9,
524-535.
24)
M. Gerlitz, P. Hammann, R. Thiericke, and J. Rohr*: The Biogenetic Origin of the
Carbon Skeleton and the Oxygen Atoms of Elaiophylin, a Symmetric Macrodiolide
Antibiotic. J. Org. Chem. 1992, 57, 4030-4033.
25)
E. Egert*, M. Noltemeyer, J. Siebers, J. Rohr, and A. Zeeck: The Structure of Tetracenomycin C. J. Antibiot. 1992, 45, 1190-119
26)
J. Rohr: Comparison of Multicyclic Polyketides by Folding Analysis - A Novel
Approach to Recognize Biosynthetic and/or Evolutionary Interrelationships of the
Natural Products or Intermediates, and Its Exemplification on Hepta-, Octa- and
Decaketides. J. Org. Chem. 1992, 57, 5217-5223.
27)
J. Rohr*, M. Schönewolf, G. Udvarnoki, K. Eckardt, G. Schumann, C. Wagner, J. M.
Beale and S. D. Sorey: Investigations on the Biosynthesis of the Angucycline Group
Antibiotics Aquayamycin and the Urdamycins A and B - Results from the Structural
Analysis of Novel Blocked Mutant Products. J. Org. Chem. 1993, 58, 2547-2551.
28)
J. Rohr: 5. Irseer Naturstofftage der Dechema. Nachr. Chem. Techn. Lab. 1993, 41, 559564.
29)
J. Rohr: Wirkstoffe der Natur werden für den Pflanzenschutz wieder zunehmend
attraktiver. Frankfurter Allgemeine Zeitung, Blick durch die Wirtschaft 1993
(11.6.1993), 36 (110), 8.
30)
R. Thiericke and J. Rohr: Biological Variation of Microbial Metabolites by Precursordirected Biosynthesis, Nat. Prod. Rep. 1993, 10, 265-289.
31)
J. Rohr: Mikroorganismen zeigen Wege für die Synthese auf. Handelsblatt 1993
(18.11.93) 46 (223), 38.
32)
J. Rohr: Von Leitstrukturen zu Wirkstoffen. Nachr. Chem. Tech. Lab. 1993, 41 (12),
359-1362.
33)
H. Bockholt, G. Udvarnoki, J. Rohr*, U. Mocek, J. M. Beale, H. G. Floss: Biosynthetic
Studies on the Xanthone Antibiotics Lysolipins X and I. J. Org. Chem. 1994, 59, 20642069.
34)
H. Bockholt, J. M. Beale, J. Rohr*: Biosynthetic Investigations on Pyridazomycin.
Angew. Chem. Int. Ed. Engl. 1994, 33, 1648-1651.
35)
S. Weber, C. Zolke, J. M. Beale, and J. Rohr*: Investigations of the Biosynthesis and
Structural Revision of Landomycin A. J. Org. Chem. 1994, 59, 4211-4214.
36)
G. Udvarnoki, C. Wagner, R. Machinek, and J. Rohr*: Biosynthetic Origin of the
Oxygen Atoms of Tetracenomycin C. Angew. Chem. Int. Ed. Engl.1995, 34, 565-567.
37)
J. Rohr: Trends Organische Chemie - Naturstoffe, Nachr. Chem. Tech. Lab. 1995, 43
(2), 163-168.
38)
J. Rohr: Combinatorial Biosynthesis - An Approach in the Near Future? Angew. Chem.
Int. Ed. Engl. 1995, 34, 881-885.
39)
H. Decker, S. Haag, G. Udvarnoki, J. Rohr*: Novel Genetically Engineered
Tetracenomycins. Angew. Chem. Int. Ed. Engl. 1995, 34, 1107-1110.
40)
M. Gerlitz, G. Udvarnoki, J. Rohr*: Novel Emycins and Their Biosynthetic Relations
from the Mutant Strain Streptomyces cellulosae ssp. griseoincarnatus 1114-2. Angew.
Chem. Int. Ed. Engl. 1995, 34, 1617-1621.
41)
H. Decker, J. Rohr, H. Motamedi, H. Zähner, C. R. Hutchinson*: Identification of
Streptomyces olivaceus Tü 2353 Genes Involved in the Production of the Polyketide
Antibiotic Elloramycin and Their Use in Hybrid Antibiotic Production. Gene 1995, 166,
121-126.
42)
M. Gerlitz, G. Udvarnoki, J. Rohr*: Neue Naturstoffe durch Manipulation der
Biosynthesegene. GIT Fachz. Lab. 1995, 39, 888-890.
43)
H. Decker*, J. Rohr*, H. Motamedi, C. R. Hutchinson, H. Zähner: Isolation of Hybrid
Antibiotics from Streptomyces fradiae Tü2717. Biotekhnologiya 1995, 68-72.
44)
S. Blum, I. Groth, J. Rohr*, H. P. Fiedler*: Dioxolides, Novel Secondary Metabolites
from Streptomyces tendae. J. Basic Microbiol. 1996, 36, 19-25.
45)
H. Depenbrock, S. Bornschlegl, R. Peter, J. Rohr, P. Schmid, P. Schweighart, T. Block,
J. Rastetter, A.-R. Hanauske*: Assessment of Antitumor Activity of Landomycin A
(NSC 6399187-A). Ann. Hematol. 1996, 73 (Supl. II), A 80.
46)
K. Krohn, J. Rohr: Angucyclines: Total Syntheses, New Structures, and Biosynthetic
Studies of an Emerging New Class of Antibiotics. Topics Curr. Chem. 1997, 188, 127195.
47)
A. Kirschning, A. Bechthold, J. Rohr: Chemical and Biochemical Aspects of
Deoxysugars and Therefrom Derived Oligosaccharides. Topics Curr. Chem. 1997, 188,
1-84.
48)
J. Rohr*, S.-E. Wohlert, C. Oelkers, A. Kirschning, M. Ries: Biosynthetic Short Activation of the 2,3,6-Trideoxysugar L-Rhodinose. Chem. Commun. 1997, 973-974.
49)
G. Meurer, M. Gerlitz, E. Wendt-Pienkowski, L. C. Vining, J. Rohr*, C. R.
Hutchinson*: Iterative, Type II Polyketide Synthases, Cyclases and Ketoreductases
Exhibit Context Dependent Behavior in the Biosynthesis of Linear and Angular
Decapolyketides. Chem. Biol. 1997, 4, 433-443.
50)
E. Künzel, S.-E. Wohlert, C. Beninga, S. Haag, H. Decker, C. R. Hutchinson, G.
Blanco, C. Mendez, J. A. Salas, J. Rohr*: Tetracenomycin M, a Novel Genetically
Engineered Tetracenomycin Resulting from a Combination of Mithramycin and
Tetracenomycin Biosynthetic Genes. Chem. Eur. J. 1997, 3, 1675-1678.
51)
J. Rohr: Biosynthesis of Taxol, Angew. Chem. Int. Ed. Engl. 1997, 36, 2190-2195.
52)
J. Rohr*, U. Weißbach, C. Beninga, E. Künzel, K. Siems, K. U. Bindseil, F. Lombó, L.
Prado, A. F. Braña, C. Méndez, J. A. Salas: The Structure of Premithramycinone
and Demethylpremithramycinone, Plausible Early Intermediates of the Aureolic Acid
Group Antibiotic Mithramycin, Chem. Commun. 1998, 437-438.
53)
J. Rohr: Oxygenases and Glycosyltransferases in Combinatorial Biosynthetic
Approaches. In: Synthesis and Applications of Isotopically Labelled Compounds 1997,
Eds. J. R. Heys, D. G. Mellilo, J. Wiley & Sons, Chichester, New York 1998, Paper 52,
267-271.
54)
B. P. Matselyukh*, V. V. Lukyantschyk, L. V. Polishtschuk, A. V. Matselyukh, J. Rohr:
Number of restriction sites of both plasmids of Streptomyces globisporus pSG1912.
Biopolymers and Cell (Ukr.) 1998, 14, 238-241.
55)
E. Fernández, U. Weißbach, C. Sánchez Reillo, A. F. Braña, C. Méndez, J. Rohr*, J. A.
Salas*: Identification of Two Genes from Streptomyces argillaceus Encoding Two
Glycosyltransferases Involved in the Transfer of a Disaccharide During the Biosynthesis
of the Antitumor Drug Mithramycin, J. Bacteriol. 1998,180, 4929-4937.
56)
S.-E. Wohlert, G. Blanco, F. Lombó, E. Fernández, A. F. Braña, S. Reich, G.
Udvarnoki, C. Méndez, H. Decker, J. Frevert, J. A. Salas, J. Rohr*: Novel Hybrid
Tetracenomycins Through Combinatorial Biosynthesis Using a Glycosyltransferase
Encoded by the elm-Genes in Cosmid 16F4 Which Shows a Broad Sugar Substrate
Specificity, J. Am. Chem. Soc. 1998, 120, 10596-10601.
57)
S.-E. Wohlert, E. Künzel, R. Machinek, C. Méndez, J. A. Salas, J. Rohr*: The Structure
of Mithramycin Reinvestigated, J. Nat. Prod. 1999, 62, 119-121.
58)
L. Prado, F. Lombó, A. F. Braña, C. Méndez, J. Rohr*, and J. A. Salas*: Analysis of
two Chromosomal Regions Adjacent to a Type II Polyketide Synthase Involved in the
Biosynthesis of the Antitumor Polyketide Mithramycin in Streptomyces argillaceus.
Mol. Gen. Genet. 1999, 261, 216-225.
59)
J. Rohr*, C. Méndez, J. A. Salas: The Biosynthesis of Aureolic Acid Antibiotics,
Bioorg. Chem. 1999, 27, 41-54.
60)
L. Prado, E. Fernández, U. Weißbach, G. Blanco, L. M. Quirós, A. F. Braña, C.
Méndez, J. Rohr*, J. A. Salas*: Oxidative Cleavage of Premithramycin B is one of the
last Steps in the Biosynthesis of the Antitumor Drug Mithramycin. Chem. Biol. 1999, 6,
19-30.
61)
M. Walker, E. Pohl, R. Herbst-Irmer, M. Gerlitz, J. Rohr, G. M. Sheldrick*: Absolute
configurations of Emycin D, E, and F; mimicry of centrosymmetric space groups
bymixtures of chiral stereoisomers. Acta Cryst. 1999, B55, 607-616.
62)
A. Kirschning*, C. Oelkers, M. Ries, A. Schönberger, S.-E. Wohlert, J. Rohr*:
Biosynthetic Studies on Deoxysugars: Implications for Enzyme-Mediated Synthesis of
Deoxyoligosaccharides, in Bioorganic Chemistry, eds. U. Diederichsen, T. K. Lindhorst,
B. Westermann, L. A. Wessjohann, Wiley-VCH, Weinheim, New York, Chichester,
Brisbane, Singapore, Toronto 1999, 298-304.
63)
S.-E. Wohlert, A. Bechthold, C. Beninga, T. Henkel, M. Holzenkämpfer, A. Kirschning,
C. Oelkers, M. Ries, S. Weber, U. Weißbach, L. Westrich, J. Rohr*: Investigations on
the Biosynthesis of Landomycin A, in Bioorganic Chemistry, eds. U. Diederichsen, T.
K. Lindhorst, B. Westermann, L. A. Wessjohann, Wiley-VCH, Weinheim, New York,
Chichester, Brisbane, Singapore, Toronto 1999, 305-312.
64)
A. Bechthold, J. Rohr: Oligosaccharide Antibiotics: Perspective for Combinatorial
Biosynthesis, in Bioorganic Chemistry, eds. U. Diederichsen, T. K. Lindhorst, B.
Westermann, L. A. Wessjohann, Wiley-VCH, Weinheim, New York, Chichester,
Brisbane, Singapore, Toronto 1999, 313-321.
65)
E. Künzel, B. Faust, C. Oelkers, U. Weissbach, D. W. Bearden, G. Weitnauer, L.
Westrich, A. Bechthold, J. Rohr*: The Inactivation of the urdGT2 Gene, Which
Encodes a Glycosyltransferase Responsible for the C-Glycosyltransfer of Activated DOlivose, Leads to the Formation of the Three Novel Urdamycins I, J and K. J. Am.
Chem. Soc., 1999, 121, 11058-11062.
66)
A. Trefzer, D. Hoffmeister, E. Künzel, S. Stockert, G. Weitnauer, L. Westrich, U. Rix, J.
Fuchser, K. U. Bindseil, J. Rohr*, A. Bechthold*: Function of Glycosyl Transferase
Genes Involved in Urdamycin A Biosynthesis. Chem. Biol. 2000, 7, 133-142.
67)
Ma J. Fernández Lozano, L. L. Remsing, L. M. Quirós, A. F. Braña, E. Fernández, C.
Sánchez, C. Méndez, J. Rohr*, J. A. Salas*: Characterization of Two Polyketide
Methyltransferases Involved in the Biosynthesis of the Antitumor Drug Mithramycin by
Streptomyces argillaceus. J. Biol. Chem. 2000, 275, 3065-3074.
68)
B. Faust, D. Hoffmeister, G. Weitnauer, L. Westrich, S. Haag, P. Schneider, H. Decker,
E. Künzel, J. Rohr, A. Bechthold*: Two new tailoring enzymes, a glycosyltransferase
and an oxygenase, involved in biosynthesis of the angucycline antibiotic urdamycin A in
Streptomyces fradiae Tü2717. Microbiol. 2000, 146, 147-154.
69)
F. Lombó, E. Künzel, L. Prado, A. F. Braña, K. U. Bindseil, J. Frevert, D. W. Bearden,
C. Méndez, J. A. Salas*, J. Rohr*: The Novel Hybrid Antitumor Compound
Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the
Biosynthesis of the Aureolic Acid Antibiotic Mithramycin. Angew. Chem. Int. Ed. Engl.
2000, 39, 796-799.
70)
G. Blanco, E. Fernández, Ma J. Fernández, A. F. Braña, U. Weißbach, E. Künzel, J.
Rohr*, C. Méndez, J. A. Salas*: Characterization of Two Glycosyltransferases Involved
in Early Glycosylation Steps During Biosynthesis of the Antitumor Polyketide
Mithramycin by Streptomyces argillaceus. Mol. Gen. Genet. 2000, 262, 991-1000.
71)
J. Rohr: New Roles for Polyketides. Angew. Chem. Int. Ed. 2000, 39, 2847-2849
72)
L. Rodriguez, C. Oelkers, I. Aguirrezabalaga, A. F. Braña, J. Rohr*, C. Méndez, J. A.
Salas*: Generation of hybrid elloramycin analogs by combinatorial biosynthesis using
genes from anthracycline-type and macrolide pathways. J. Mol. Microbiol. Biotechnol.
2000, 2, 271-276.
73)
D. Hoffmeister, K. Ichinose, S. Domann, B. Faust, A. Kirschning, E. Künzel, J. Rohr*,
A. Bechthold*: The NDP-sugar co-substrate concentration and the enzyme expression
level influence the substrate specificity of glycosyltransferases: Cloning and
characterization of deoxysugar biosynthetic genes of the urdamycin biosynthetic gene
cluster. Chem. Biol. 2000, 7, 821-831.
74)
A. González, L. L. Remsing, F. Lombó, M. J. Fernández, L. Prado, A. F. Braña, E.
Künzel, J. Rohr*, C. Méndez, J. A. Salas*: The mtmVUC genes of the antitumor
mithramycin gene cluster are involved in the biosynthesis of the sugar moieties. Mol.
Gen. Genet. 2001, 264, 827-835.
75)
G. Blanco, E. P. Patallo, A. F. Braña, A. Trefzer, A. Bechthold, J. Rohr*, C. Méndez, J.
A. Salas*: Identification of a sugar flexible glycosyltransferase from Streptomyces
olivaceus, the producer of the antitumor polyketide elloramycin. Chem. Biol. 2001, 8,
253-263.
76)
E. Pérez Patallo, G. Blanco, C. Fischer, A. F. Braña, J. Rohr*, C. Méndez, J. A. Salas*:
Deoxysugar methylation during biosynthesis of the antitumor polyketide elloramycin by
Streptomyces olivaceus: characterization of three methyltransferase genes. J. Biol.
Chem. 2001, 276, 18765-18774.
77)
A. Trefzer, C. Fischer, S. Stockert, L. Westrich, E. Künzel, U. Girresser, J. Rohr*, A.
Bechthold*: Elucidation of ther function of two glycosyltransferase genes (lanGT1 and
lanGT4) involved in landomycin biosynthesis and generation of new oligosaccharide
antibiotics. Chem. Biol. 2001, 8, 1239-1252.
78)
L. L. Remsing, J. Garcia-Bernardo, A. Gonzalez, E. Künzel, U. Rix, A. F. Braña, D. W.
Bearden, C. Méndez, J. A. Salas*, J. Rohr*: Ketopremithramycins and
ketomithramycins: Four new aureolic acid type compounds obtained upon inactivation
of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor
drug mithramycin by Streptomyces argillaceus. J. Am. Chem. Soc. 2002, 124, 16061614.
79)
T. Macky, C. Oelkers, U. Rix, M. L. Heredia, E. Künzel, M. Wimberley, B. Rohrer, C.
Crosson, J. Rohr*: Synthesis, pharmacokinetics and rat retinal toxicity of a novel
mitomycin C-triamcinolone acetonide conjugate. J. Med. Chem. 2002, 45, 1122-1127.
80)
C. Sánchez1, I. A. Butovich2, A. F. Braña, J. Rohr*, C. Méndez, J. A. Salas*: The
biosynthetic gene cluster for the antitumor rebeccamycin from Saccharothrix
aerocolonigenes ATCC39243: characterization and generation of indolocarbazole
derivatives. Chem. Biol. 2002, 9, 519-531.
81)
C. Méndez, E. Künzel, F. Lipata, F. Lombó, W. Cotham, M. Walla, D. W. Bearden, A.
F. Braña, J. A. Salas, J. Rohr*: Oviedomycin, a novel unusual angucyclinone encoded
by genes of the oleandomycin-producer Streptomyces antibioticus ATCC11891. J. Nat.
Prod. 2002, 65, 779-782.
82)
A. Trefzer, G. Blanco, L. Remsing, E. Künzel, U. Rix, A. F. Braña, C. Méndez, J.
Rohr*, A. Bechthold*, J. A. Salas*: Rationally designed glycosylated premithramycins:
hybrid aromatic polyketides using genes from up to three different biosynthetic
pathways. J. Am. Chem. Soc., 2002, 124, 6056-6062.
83)
U. Rix, C. Fischer, L. L. Remsing, J. Rohr*: Modification of post-PKS tailoring steps
through combinatorial biosynthesis. Nat. Prod. Rep. 2002, 19, 542-580.
84)
C. Fischer, L. Rodríguez, E. P. Patallo, F. Lipata, A. F. Braña, C. Mendez, J. A.
Salas*, J. Rohr*: Digitoxosyltetracenomycin C and Glucosyltetracenomycin C, Two
Novel Elloramycin Analogs Obtained by Exploring the Sugar Donor Substrate
Specificity of Glycosyltransferase ElmGT. J. Nat. Prod. 2002, 65, 1685-1689.
85)
U. Rix, L. L. Remsing, D. Hoffmeister, A. Bechthold, J. Rohr*: Urdamycin L: A
Novel Metabolic Shunt Product that Provides Evidence for the Role of the urdM Gene
in the Urdamycin A Biosynthetic Pathway of Streptomyces fradiae Tü 2717.
ChemBioChem 2003, 109-111.
86)
D. Hoffmeister, G. Dräger, HK. Ichinose, J. Rohr, A. Bechthold*: The CGlycosyltyransferase UrdGT2 Is Unselective toward D- and L-Configured NucleotideBound Rhodinoses. J. Am. Chem. Soc. 2003, 125, 4678-4679.
87)
L. L. Remsing, A. M. Gonzalez, M. Nur-e-Alam, M. J. Fermandez-Lozano, A. F.
Brana, U. Rix, M. A. Oliveira, C. Mendez, J. A. Salas*, J. Rohr*: Mithramycin SK, a
novel antitumor drug with improved therapeutic index, mithramycin SA, and
demycarosyl-mithramycin SK: Three new products generated in the mithramycin
producer Streptomyces argillaceus through combinatorial biosynthesis. J. Am. Chem.
Soc. 2003, 125, 5745-5753.
88)
L. L. Remsing, H. R. Bahadori, G. M. Carbone, E. M. McGuffie, C. V. Catapano, J.
Rohr*: Inhibition of c-src Transcription by Mithramycin: Structure-Activity
Relationships of Biosynthetically-Produced Mithramycin Analogues Using the c-src
Promoter as Target. Biochemistry 2003, 42, 8313-8324.
89)
C. Fischer, F. Lipata, J. Rohr*: The Complete Gene Cluster of the Antitumor Agent
Gilvocarcin V and Its Implication for the Biosynthesis of the Gilvocarcins. J. Am.
Chem. Soc. 2003, 125(26), 7818-7819.
90)
N. Menéndez, M. Nur-e-Alam, A. F. Braña, J. Rohr*, J. A. Salas, C. Méndez*:
Biosynthesis of the Antitumor Agent Chromomycin A3 in Streptomyces griseus:
Analysis of the Gene Cluster and Rational Design of Novel Chromomycin Analogues.
Chem. Biol., 2004, 11, 21-32.
91)
B. Ostash, U. Rix, L. L. Remsing Rix, T. Liu, F. Lombo, A. Luzhetskyy, O. Gromyko,
C. Wang, A. F. Braña, C. Mendez, J. A. Salas, V. Fedorenko, J. Rohr*: Generation of
New Landomycins by Combinatorial Biosynthetic Manipulation of the LndGT4 Gene of
the Landomycin E Cluster in S. globisporus. Chem. Biol. 2004, 11, 547-555
92)
U. Rix, J. Zheng, L. L. Remsing Rix, L. Greenwell, K. Yang*, J. Rohr*: The Dynamic
Structure of Jadomycin B and the Amino Acid Incorporation Step of Its Biosynthesis. J.
Am. Chem. Soc. 2004, 126, 4496-4497.
93)
R. S. Ranga, R. Girja, M. Nur-e-Alam, S. Satishkumar, M. A. Akbarsha, S.
Thirugnanam, J. Rohr, M. M. Ahmed, D. Chendil*: Rasagenthi lehyam (RL) a novel
complementary and alternative medicine for prostate cancer. Cancer Chemother.
Pharmacol. 2004, 54, 7-15.
94)
F. J. Pérez-Zúñiga, E. M. Seco, T. Cuesta, F. Degenhardt, J. Rohr*, C. Vallín, Y.
Iznaga, M. E. Pérez, L. González, F. Malpartida*: CE-108, a new macrolide tetraene
antibiotic. J. Antibiot. 2004, 57, 197-204.
95)
N. Menéndez, M. Nur-e-Alam, A. F. Braña, J. Rohr*, J. A. Salas, C. Méndez*:
Tailoring modification of deoxysugars during biosynthesis of the antitumor drug
chromomycin A3 by Streptomyces griseus subsp. griseus. Mol. Microbiol. 2004, 53(3),
903-915.
96)
A. Luzhetskyy, T. Liu, M. Fedoryshyn, B. Ostash, V. Fedorenko, J. Rohr*, A.
Bechthold*: Function of lanGT3, a glycosyltransferase gene involved in landomycin
A biosynthesis. ChemBioChem. 2004, 5, 1567-1570.
97)
T. Liu, C. Fischer, C. Beninga, J. Rohr*: Oxidative Rearrangement Processes in the
Biosynthesis of Gilvocarcin V. J. Am. Chem. Soc. 2004, 126, 12262-12263.
98)
R. L. A. Furlan, S. J. Watt, L. M. Garrido, G. P. Amarente-Mendes, M. Nur-e-Alam,
J. Rohr, A. Braña, C. Mendez, J. A. Salas, M. M. Sheil, J. L. Beck, G. Padilla*: DNABinding Properties of Cosmomycin D, an Anthracycline with Two Trisaccharide
Chains. J. Antibiot. 2004, 57(10), 647-654.
99)
F. Lombó, M. Gibson, L. Greenwell, A. F. Braña, J. Rohr*, J. A. Salas, C. Méndez*:
Engineering Biosynthetic Pathways for Deoxysugars: Branched-Chain Sugar
Pathways and Derivatives from the Antitumor Tetracenomycin. Chem. Biol. 2004, 11,
1709-1718.
100)
C. Sánchez, L. Zhu, A. F. Braña, A. P. Salas, J. Rohr*, C. Méndez, and J. A. Salas*:
Combinatorial Biosynthesis of Antitumor Indolocarbazole Compounds. Proc. Natl.
Acad. Sci. USA 2005, 102, 461-466.
101)
L. Zhu, B. Ostash, A. Mayers, A. Luzhetskyy, C. Mendez, J. A. Salas, A. Bechthold,
V. Fedorenko*, J. Rohr*: Identification of the Function of Gene lndM2 Encoding a
Bifunctional Oxygenase-Reductase Involved in the Biosynthesis of the Antitumor
Antibiotic Landomycin E by Streptomyces globisporus 1912 Supports the Originally
Assigned Structure for Landomycinone. J. Org. Chem. 2005, 70, 631-638.
102)
S. Sowmyalakshmi, M. Nur-e-Alam, M. A .Akbarsha, S. Thirugnanam, J. Rohr, D. Chendil*:
Investigation on Semecarpus Lehyam (SL) - a Siddha medicine for Breast cancer. Planta 2005,
220, 910-918.
103)
M. Pérez, M. Gibson, F. Lombó, A. F. Braña, J. Rohr, J. A. Salas, C. Méndez:
Combining antitumor sugar biosynthesis genes (cassettes) to generate two novel
glycosylated (antitumor) elloramycins. Chem. Commun. 2005, 1604-1606.
104)
A. Luzhetskyy, L. Zhu, M. Gibson, M. Fedoryshyn, C. Dürr, C. Hofmann, D.
Hoffmeister, B. Ostash, C. Mattingly, V. Adams, V. Fedorenko, J. Rohr, A.
Bechthold: Generation of novel landomycins M and O through targeted gene
disruption. ChemBioChem 2005, 6, 675-678.
105)
M. Nur-e-Alam, C. Méndez, J. A. Salas, J. Rohr*: Elucidation of the Glycosylation
Sequence of Mithramycin Biosynthesis: Isolation of 3A-Deolivosylpremithramycin B
and Its Conversion to Premithramycin B by Glycosyltransferase MtmGII.
ChemBioChem 2005, 6, 632-636.
106)
U. Rix, C. Wang, Y. Chen, F. M. Lipata, L. L. Remsing Rix, L. M. Greenwell, L. C.
Vining, K. Yang*, J. Rohr*: The Oxidative Ring Cleavage in Jadomycin
Biosynthesis: A Multistep Oxygenation Cascade in a Biosynthetic Black Box.
ChemBioChem 2005, 6, 838-845.
107)
Y.-H. Chen, C.-C. Wang, L. Greenwell, U. Rix, D. Hoffmeister, L. C. Vining, J.
Rohr*, K.-Q. Yang*: Functional Analyses of Oxygenases in Jadomycin Biosynthesis
and Identification of JadH as a Bifunctional Oxygenase/Dehydrase. J. Biol. Chem.
2005, 280, 22508-22514.
108)
J.-T. Zheng, U. Rix, L. Zhao, C. Mattingly, V. Adams, Q. Chen*, J. Rohr*, KQ. Yang*: Cytotoxic Activities of New Jadomycin Derivatives. J. Antibiot.
2005, 58, 405-408.
109)
A. P. Salas, L. Zhu, C. Sánchez, A. F. Braña, J. Rohr, C. Méndez, J. A. Salas*:
Deciphering the late steps in the biosynthesis of the anti-tumor indolocarbazole
staurosporin: sugar donor substrate flexibility of the StaG glycosyltransferase. Mol.
Microbiol. 2005, 58, 17-27.
110)
C. Wang, M. Gibson, J. Rohr*, M. A. Oliveira*: Crystallization and X-ray
diffraction properties of Baeyer-Villiger monooxygenase MtmOIV from the
mithramycin biosynthetic pathway in Streptomyces argillaceus. Acta Cryst.
2005, F61, 1023-1026.
111)
M. Gibson, M. Nur-e-Alam, F. Lipata, M. A. Oliveira, J. Rohr*:
Characterization of Kinetics and Products of the Baeyer-Villiger Oxygenase
MtmOIV, the Key Enzyme of the Biosynthetic Pathway toward the Natural
Product Anticancer Drug Mithramycin from Streptomyces argillaceus. J. Am.
Chem. Soc. 2005, 127, 17594-17595.
112)
N. Menéndez, M. Nur-e-Alam, C. Fischer, A. F. Braña, J. A. Salas, J. Rohr*,
C. Méndez*: Deoxysugar Transfer during Chromomycin A3 Biosynthesis in
Streptomyces griseus subsp. griseus: New Derivatives with Antitumor
Activity. Appl. Envinronment. Microbiol. 2006, 72, 167-177.
113)
V. Albertini, A. Jain, S. Vignati, S. Napoli, A. Rinaldi, I. Kwee, M. Nur-e-Alam, J.
Bergant, F. Bertoni, G. M. Carbone, J. Rohr*, C. V. Catapano*:
Novel GC-rich DNA Binding Compounds Produced by a Genetically Engineered
Mutant of the Mithramycin Producer S. argillaceus Exhibit Improved Transcriptional
Repressor Activity: Implications for Cancer Therapy. Nucleic Acids Res. 2006, 34,
1721-1734.
114)
S. Gullón, C. Olano, M. S. Abdelfattah, A. F. Braña, J. Rohr, C. Méndez, J. A.
Salas*: Isolation, Characterization, and Heterologous Expression of the Biosynthesis
Gene Cluster for the Antitumor Anthracycline Steffimycin. Appl. Environ. Microbiol.
2006, 72, 4172-4183.
115)
T. Liu, M. K. Kharel, C. Fischer, A. McCormick, J. Rohr*: Inactivation of gilGT
Encoding a C-Glycosyltransferase and gilOIII Encoding a P450 Enzyme, Allows the
Details of the Late Biosynthetic Pathway to Gilvocarcin V to be Delineated.
ChemBioChem 2006, 7, 1070-1077.
116)
L. M. Garrido, F. Lombó, I. Baig, M. Nur-e-Alam, C. Méndez, J. A. Salas*, J. Rohr*,
G. Padilla*: Insights in the glycosylation steps during biosynthesis of the antitumor
anthracycline cosmomycin: characterization of two glycosyltransferase genes. Appl.
Microbiol. Biotechnol. 2006, 73, 122-131.
117)
M. S. Abdelfattah, J. Rohr: Premithramycinone G, an Early Shunt Product of the
Mithramycin Biosynthetic Pathway Accumulated upon Inactivation of Oxygenase
MtmOII. Angew. Chem. Int. Ed., 2006, 45, 5685-5689.
118)
M. Pérez, F. Lombó, I. Baig, A. F. Braña, J. Rohr*, J. A. Salas, C. Méndez*:
Combinatorial Biosynthesis of Deoxysugar Pathways in Streptomyces: Reconstitution
of “Unnatural Natural Gene Clusters” for the Biosynthesis of four 2,6-Ddideoxyhexoses. Appl. Environ. Microbiol. 2006, 72, 6644-6652.
119)
I. Baig, M. Kharel, A. Kobylyanskyy, L. Zhu, Y. Rebets, B. Ostash, A. Luzhetskyy, A.
Bechthold, V. A. Fedorenko* J. Rohr*: On the Acceptor Substrate of CGlycosyltransferase UrdGT2: Three Prejadomycin C-Glycosides From an Engineered
Mutant of Streptomyces globisporus 1912 lndE(urdGT2). Angew. Chem. Int. Ed.,
2006, 45, 7842-7846.
120)
J. Rohr*: Cryptophycin Anticancer Drugs Revisited. ACS Chem. Biol. 2006, 1, 747750.
121)
L. Zhu, A. Luzhetskyy, M. Luzhetska, C. Mattingly, V. Adams, A. Bechthold*, J.
Rohr*: Generation of New Landomycins with Altered Saccharide Pattern through
Over-expression of Glycosyltransferase Gene lanGT3 in the Biosynthetic Gene
Cluster of Landomycin A in Streptomyces cyanogenus S-136. ChemBioChem 2007, 8,
83-88.
122)
M. K. Kharel, L. Zhu, T. Liu, J. Rohr*: Multi-Oxygenase Complexes of the
Gilvocarcin and Jadomycin Biosyntheses. J. Am. Chem. Soc. 2007, 129, 3780-3781.
123)
M. Fedoryshyn, M. Nur-e-Alam, L. Zhu, A. Luzhetskyy, J. Rohr*, A. Bechthold*:
Surprising Production of a New Urdamycin Derivative by S. fradiae Q/R. J.
Biotechnol. 2007, 1308, 32-38.
124)
I. Baig, M. Perez, A. F. Braña, R. Gomathinayagam, C. Damodaran, J. A. Salas, C.
Méndez*, J. Rohr*: Mithramycin Analogues Generated by Combinatorial
Biosynthesis Show Improved Bioactivity. J. Nat. Prod. 2008, 71, 199-207.
125)
C. Olano, M. S. Abdelfattah, S. Gullón, A. F. Braña, J. Rohr, C. Méndez, J. A. Salas*:
Glycosylated Derivatives of Steffimycin: Insights into the Role of the Sugar Moieties
for the Biological Activity. ChemBioChem 2008, 9, 624-633.
126)
A. Ramos, F. Lombó, A. F. Braña, J. Rohr, C. Méndez, J. A. Salas*: Biosynthesis of
elloramycin in Streptomyces olivaceus requires glycosylation by enzymes encoded
outside the aglycon cluster. Microbiology 2008, 154, 781-788.
127)
M. Pérez, I. Baig, A. F. Braña, J. A. Salas, J. Rohr*, C. Méndez*: Generation of New
Derivatives of the Antitumor Antibiotic Mithramycin by Altering the Glycosylation
Pattern through Combinatorial Biosynthesis. ChemBioChem 2008, 9, 2295-2304.
128)
M. S. Abdelfattah, M. K. Kharel, J. A. Hitron, I. Baig, J. Rohr*: Moromycins A and
B: Isolation and Structure Elucidation of New C-Glycosylangucycline Type
Antibiotics from Streptomyces sp.KY002. J. Nat. Prod. 2008, 71, 1569-1573.
129)
W. Zhao, L. Zhu, S. Srinivasan, C. Damodaran, J. Rohr*: Identification of Urushioles
as the Major Active Principle of the Siddha Herbal Medicine Semicarpus Lehyam:
Anti-tumor Agents for the Treatment of Breast Cancer. Pharm. Biol. 2009, 47(9), 886893.
130)
J. Cain*, E. P. Black, J. Rohr*: An Audience Response System Strategy to Improve
Student Motivation, Attention and Feedback in a Physiological Chemistry / Molecular
Biology Course. Am. J. Pharm. Educ. 2009, 73(2); Article 21.
131)
R. Kumar, S. Srinivasan, S. Koduru, P. Pahari, J. Rohr, N. Kyprianou, C.
Damodaran*: Psoralidin, an Herbal Molecule Inhibits PI3K Mediated Akt Signaling
in Androgen Independent Prostate Cancer (AIPC) Cells. Cancer Prevention Res.
2009, 2, 234-243.
132)
F. Lombó, M. S. Abdelfattah, A. F. Braña, J. A. Salas, J. Rohr*, C. Méndez*:
Elucidation of Oxygenation Steps during Oviedomycin Biosynthesis and Generation
of Derivatives with Increased Antitumor Activity. ChemBioChem. 2009, 10, 296-303.
133)
T. Liu, M. K. Kharel, L. Zhu, S. A. Bright, C. Mattingly, V. R. Adams, J. Rohr*:
Inactivation of the Ketoreductase gilU Gene of the Gilvocarcin Biosynthetic Gene
Cluster Yields New Analogues with Partly Improved Biological Activity.
ChemBioChem 2009, 10, 278-286.
134)
P. Pahari, J. Rohr*: Total Synthesis of Psoralidin, an Anticancer Natural Product, J.
Org. Chem. 2009, 74, 2750-2754.
135)
S. Koduru, S. Sowmyalakshmi, R. Kumar, J. Rohr, C. Damodaran*: Identification of
a Potent Herbal Molecule for the Treatment of Breast Cancer, BMC Cancer 2009,
9:41.
136)
M. K. Kharel, P. Pahari, H. Lian, J. Rohr*: GilR, and Unusual Lactone-Forming
Enzyme Involved in Gilvocarcin Biosynthesis, ChemBioChem 2009, 10, 1305-1308.
137)
M. Beam, M. A. Bosserman, N. Noinaj, M. Wehenkel, J. Rohr*: Crystal Structure of
Baeyer-Villiger Monooxygenase MtmOIV, the Key Enyzme of the Mithramycin
Biosynthetic Pathway, Biochemistry 2009, 48, 4476-4487.
138)
B. Ostash, I. Ostash, L. Zhu, M. K. Kharel, A. Luzhetskyy, A. Bechthold, S. Walker,
J. Rohr, V. Fedorenko*: Properties of lanK-based regulatory circuit involved in
landomycin biosynthesis in Streptomyces cyanogenus S136, Russian J. Genet. 2010,
46, 530-535.
139)
J. Rohr*, C. Hertweck: Type II PKS, in Comprehensive Natural Products IIChemistry and Biology, Volume 1 - Structural Diversity I (Fatty Acids, Polyketide
Synthases, Terpenes), ISBN-13: 978-0-08-045381-1, L. Mander, H.-W. Liu, ed.,
Elsevier, Oxford, 2010, pp 227-303.
140)
M. K. Kharel, S. E. Nybo, M. D. Shepherd, J. Rohr: Cloning and Characterization of
the Ravidomycin and Chrysomycin Biosynthetic Gene Clusters, ChemBioChem 2010,
11, 523-532. PMID: 20140934
141)
M. D. Shepherd, M. K. Kharel, M. A. Bosserman, J. Rohr: Laboratory Maintenance of
Streptomyces species, Curr. Protoc. Microbiol. 2010, Chapter 10: Unit 10E.1 PMID
20812215
142)
M. K. Kharel, P. Pahari, H. Lian, J. Rohr: Enzymatic Total Synthesis of Rabelomycin,
an Angucycline Group Antibiotic, Org. Lett. 2010, 8, 3851-3856. PMID 2086694
143)
M. A. Bosserman, M. D. Shepherd, M. K. Kharel, J. Rohr: Laboratory Maintenance of
Streptomyces argillaceus and Streptomyces griseus, Curr. Protoc. Microbiol. 2010,
Chapter 10: Unit 10E.2 PMID 21053252
144)
M. D. Shepherd, M. K. Kharel, L. L. Zhu, S. G. Van Lanen, J. Rohr: Delineating the
Earliest Steps of Gilvocarcin Biosynthesis: Role of GilP and GilQ in Starter Unit
Specificity, Org. Biomol. Chem. 2010, 8, 3851-3856. PMID 20617244
145)
S. E. Nybo, M. D. Shepherd, M. A. Bosserman, J. Rohr: Genetic Manipulation of
Streptomyces Species, Curr. Protoc. Microbiol. 2010, Chapter 10: Unit 10E.3. PMID
21053253
146)
R. Kumar, S. Srinivasan, P. Pahari, J. Rohr, C. Damodaran*: Activating StressActivated Protein Kinase-Mediated Cell Death and Inhibiting Epidermal Growth
Factor Receptor Signaling: A Promising Therapeutic Strategy for Prostate Cancer,
Mol. Cancer Ther. 2010, 9, 2488-2496. PMID:20736346
147)
M. K. Kharel, M. D. Shepherd, S. E. Nybo, M. A. Bosserman, J. Rohr: Isolation of
Streptomyces species from Soil, Curr. Protoc. Microbiol. 2010, Chapter 10: Unit
10E.4. PMID 21053254
148)
S. Previdi, A. Malek, V. Albertini, C. Riva, C. Capella, M. Broggini, G. M. Carbone,
J. Rohr and C. V. Catapano*: Inhibition of Sp1 dependent transcription and antitumor
activity of the new aureolic acid analogues Mithramycin SDK and SK in human
ovarian cancer xenografts, Gyn. Oncol. 2010, 118, 182-188. PMID: 20452660
149)
J. Rohr: Modifying Oxidation and Glycosylation Events in Biosyntheses of Natural
Product Anticancer Drugs – Challenges for Combinatorial Biosynthesis, in Functional
Molecules from Natural Sources, S. Wrigley, R. Thomas, C.T. Bedford, N. Nicholson,
ed., RSC Publishing, Royal Society of Chemistry, Cambridge, 2011, pp 161-183.
150)
K. A. Shaaban, C. Stamatkin, C. Damodaran, J. Rohr*: 11-Deoxylandomycinone and
landomycins X-Z, new cytotoxic angucyclin(on)es from a Streptomyces cyanogenus
K62 mutant strain, J. Antibiot. 2011, 64, 64, 141-150. PMID 20978514
151)
M. A. Bosserman, A. Florez, K. A. Shaaban, A. F. Braña, J. A. Salas, C. Méndez, J.
Rohr*: Characterization of the Terminal Activation Step Catalyzed by Oxygenase
CmmOIV of the Chromomycin Biosynthetic Pathway from Streptomyces griseus,
Biochemistry. 2011, 50, 1421-1428. PMID 21244022)
152)
Z. Yang, X. Chi., M. Funabashi, S. Baba, K. Nonaka, P. Pahari, J. Unrine, J. M.
Jacobsen, G. I. Elliott, J. Rohr, S. G. Van Lanen*: Characterization of LipL as a nonheme, Fe(II)-dependent alpha-ketoglutarate:UMP dioxygenase that generates uridine5'-aldehyde during A-90289 biosynthesis. J. Biol. Chem. 2011, 286, 7885-7892.
PMID 21216959)
153)
M. D. Shepherd, T. Liu, C. Méndez, J. A. Salas, J. Rohr*: Engineered Biosynthesis of
Gilvocarcin Analogues with Altered Deoxypyranose Moieties, Appl. Environ.
Microbiol. 2011, 77, 435-441. PMID 21075894
154)
K. A. Shaaban, S. Srinivasan, R. Kumar, C. Damodaran, J. Rohr*: Landomycins P-W,
Cytotoxic Angucyclines from Streptomyces cyanogenus S136. J. Nat. Prod. 2011, 74,
2-11 PMID 21188999
155)
M. K. Kharel, H. Lian, J. Rohr*: Characterization of the TDP-D-Ravidosamine
Biosynthetic Pathway: One-Pot Enzymatic Synthesis of TDP-D-Ravidosamine from
Thymidine-5’-phosphate and Glucose-1-Phosphate, Org. Biomol. Chem. 2011, 9,
1799-1808 PMID21264378
156)
S. F. Sleiman, B. Langley, M. Basso, X. Li, J. B. Payappilly, M. K. Kharel, H. Guo, J.
L. Marsh, L. M. Thompson, L. Mahishi, P. Ahuja, W. R. MacLellan, D. Geschwind,
G. Coppola, J. Rohr, R. R. Ratan*: Mithramycin is a gene selective Sp1 inhibitor that
identifies a biological intersection between cancer and neurodegeneration, J.
Neurosci.. 2011, 31, 6858-6870. PMID 21543616
157)
N. Noinaj, M. A. Bosserman, M. A. Schickli, G. Piszczek, M. K. Kharel, P. Pahari, S.
K. Buchanan, J. Rohr*: The Crystal Structure and Mechanism of an Unusual
Oxidoreductase, GilR, Involved in Gilvocarcin V Biosynthesis, J. Biol. Chem 2011,
286, 23533-23543. PMID 215618534
158)
S. F. Sleiman, J. Berlin, M. Basso, S. S. Karuppagounder, J. Rohr, R. R. Ratan*:
Histone deacetylase inhibitors and mithramycin A impact a similar neuroprotective
pathway at a cross road between cancer and neurodegeneration, Pharmaceuticals
2011, 4, 1183-1195 (doi: 10.3390/ph4081183)
159)
G. Wang, M. K. Kharel, P. Pahari, J. Rohr*: Investigating Mithramycin Deoxysugar
Biosynthesis: Enzymatic Total Synthesis of TDP-D-Olivose, ChemBioChem 2011, 12,
2568-2571. PMID: 21960454
160)
D. Scott, J. Rohr, Y. Bae*: Nanoparticle Formulations of Mithramycin Analogs for
Enhanced Cytotoxicity, Int. J. Nanomed. 2011, 6, 2757-2767. PMID22114504
161)
M. K. Kharel, P. Pahari, M. D. Shepherd, N. Tibrewal, S. E. Nybo, K. A. Shaaban, J.
Rohr*: Angucyclines: Biosynthesis, Mode-of-action, New Natural Products, and
Synthesis, Nat. Prod. Rep. 2012, 29, 264-325. PMID:22186970
162)
P. Pahari, M. K. Kharel, M. D. Shepherd, S. G. Van Lanen, J. Rohr*: Enzymatic Total
Synthesis of Defucogilvocarcin M and Its Implications for Gilvocarcin Biosynthesis,
Angew. Chem Int. Ed. 2012, 51, 1216-1220. PMID:22223167
163)
P. Patrikainen, P. Kallio, K. D. Klika, K. Fan, P. Mäntsälä, K. A. Shaaban, J. Rohr, K.
Yang, J. Niemi, M. Metsä-Ketelä*: Engineering Angucycline Biosynthetic Pathways
Through Combinatorial Enzymatic Synthesis, Chem. Biol. 2012, 19, 647-655.
PMID:22633416
164)
S. E. Nybo, K. A. Shaaban, M. K. Kharel, J. A. Salas, C. Méndez, H. Sutardjo, J.
Rohr*: Ketoolivosyl-tetracenomycin C: A New Ketosugar Bearing Tetracenomycin
Reveals New Insight into the Substrate Flexibility of Glycosyltransferase ElmGT,
Bioorg. Med. Chem. Lett. 2012, 22, 2247-2250. PMID:22361136
165)
I. Garcia, N. M. Vior, A. F. Braña, J. G. Sabin, J. Rohr, F. Morís, C. Méndez, J. A.
Salas: Elucidating the Biosynthetic Gene Cluster for the Hybrid PolyketideNonribosomal Peptide Collismycin A: Unusual Mechanisms for the Formation of the
2,2’-Bipyridyl Ring, Chem. Biol. 2012, 19, 399-413. PMID:22444595
166)
M. K. Kharel, P. Pahari, K. A. Shaaban, G. Wang, C. Morris, J. Rohr*: Elucidation of
Post-PKS Tailoring Steps Involved in Landomycin Biosynthesis, Org. Biomol. Chem.
2012, 10, 4256-4265. PMID:22454092
167)
M. K. Kharel, J. Rohr*: Delineation of Gilvocarcin, Jadomycin, and Landomycin
Pathways through Combinatorial Biosynthetic Enzymology, Curr. Opin. Chem. Biol.
2012, 16, 150-161. PMID:22465094
168)
L. E. Núñez, S. E. Nybo, J. González-Sabín, M. Pérez, N. Menéndez, A. F. Braña, K.
A. Shaaban, M. He, F. Morís, J. A. Salas, J. Rohr*, C. Méndez*: A Novel
Mithramycin Analogue with High Antitumor Activity and Less Toxicity Generated by
Combinatorial Biosynthesis, J. Med. Chem. 2012, 55, 5813-5825. PMID:22578073
169)
K. A. Shaaban, T. A. Ahmed, M. Leggas, J. Rohr*: Saquayamycins G-K, Cytotoxic
Angucyclines from Streptomyces sp. Including Two Analogues Bearing the
Aminosugar Rednose, J. Nat. Prod. 2012, 75, 1383-1392. PMID:22758660
170)
N. Tibrewal, T. E. Downey, S. G. Van Lanen, E. Ul Sharif, G. A. O’Doherty, J.
Rohr*: Roles of the Synergistic Reductive O-Methyltransferase GilM and of OMethyltransferase GilMT in the Gilvocarcin Biosynthetic Pathway, J. Am. Chem. Soc.
2012, 134, 12402-12405. PMID:22800463.
171)
M. Bosserman, T. Downey, N. Noinaj, , S. K. Buchanan, J. Rohr *: Premithramycin
B-Bound Crystal Structure Provides Molecular Insight into Substrate Recognition and
Catalysis in the Baeyer−Villiger Monooxygenase MtmOIV, J. Biol. Chem. 2012,
under revision.
172)
G. Wang, P. Pahari, M. K. Kharel, S. G. Van Lanen, J. Rohr*: In Vitro Studies Reveal
Two Bifunctional Enzymes Involved in the Biosynthesis of Deoxysugars of the
Antitumor Antibiotic Mithramycin, Angew. Chem. 2012, accepted
173)
N. Tibrewal, J. Rohr, G. I. Elliott*: Design, Synthesis and Evaluation of AdSS
Bisubstrate Inhibitors, Bioorg. Med. Chem. Lett. 2012, submitted
174)
K. A. Shaaban, M. D. Shepherd, T. A. Ahmed, S. E. Nybo, M. Leggas, J. Rohr*:
Pyramidamycins A-D and 3-Hydroxyquinoline-2-carboxamide; Cytotoxic
Benzamides from Streptomyces sp. DGC1, J. Antibiot. 2012, 65, accepted.
175)
A. F. Braña, P. Pahari, L. A. García, J. Rohr, G. Blanco*: Activation of Silent
Antibiotic Biosynthesis in Streptomyces Through Heterlogous Expression of Genes
within the Thienamycin Cluster from S. cattleya, J. Biotecnol. 2012, submitted