MIMM 414, 2010
Advanced Immunology MIMM 414 (3 credits)
McGill University, Department of Microbiology and Immunology
Fall Term 2010
Prerequisites:
Immunology MIMM 314
Course Coordinator:
Dr. Sylvie Fournier
Dept. Microbiology and Immunology
Lyman Duff Building, Room 603
Tel: 398-7273
Fax: 398-7052
Email: sylvie.fournier@mcgill.ca
Lecturers:
Dr. Sylvie Fournier
Dr. Martin Olivier, Dept. Microbiology and Immunology, McGill
University, 514-398-5592, martin.olivier@mcgill.ca
Dr. Nassima Fodil-Cornu, Bellini Building, McGill University.
514-398-2360, nassima.fodil-cornu@mail.mcgill.ca
Dr. Trina Johnson, Neuroimmunolgy, MNI, McGill University,
514-398-8535, trina.johnson@mcgill.ca
Dr. Marianna Newkirk, Montreal General Hospital, McGill
University, marianna.newkirk@mcgill.ca
Dr. Nathalie Labrecque, University of Montreal, 514-252-3552,
nathalie.labrecque@umontreal.ca
Dr. Peter Darlington, MNI, McGill University,
peter.darlington@mcgill.ca
Dr. Florence Dzierszinski, Institute of Parasitology, McGill
University, 514-398-8764.
florence.dzierszinski@mcgill.ca
Dr. Ciriaco A. Piccirillo, Dept. Microbiology and Immunology,
514-398-2872, ciro.piccirillo@mcgill.ca
Dr. Amit Bar-Or, MNI, McGill University, 514-398-5132
amit.bar-or@mcgill.ca
Dr. Woong-Kyung Suh, IRCM, 514-987-5720, WoongKyung.Suh@ircm.qc.ca
Dr. Ji Zhang, McGill Centre for Research on Pain
Suite 3200C, Genome Building, McGill University, 514-398-7203,
ext. 00036#, Ji.Zhang@mcgill.ca
Dr. Jorg Fritz, Bellini Building, McGill University, 514-398-1707,
jorg.fritz@mcgill.ca
Teaching assistant:
Felix Hugentobler
Lyman Duff Room 617
Tel: 514-398-8882
Email: felix.hugentobler@mail.mcgill.ca
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MIMM 414, 2010
Lectures:
Monday, Wednesday, Friday 11:30-12:30
Lyman Duff Building, Room 507/509
Course Schedule
Day
Date
Month
Lecturer
Topic
Wed
Fri
1
3
September
“
Dr Fournier
Dr Fodil-Cornu
Introduction
Regulation of NK cells activity I
Mon
Wed
Fri
6
8
10
“
“
“
LABOR DAY
Dr Fodil-Cornu
Dr Fodil-Cornu
Regulation of NK cells activity II
Regulation of NK cells activity III
Mon
Wed
Fri
13
15
17
“
“
“
Dr Olivier
Dr Olivier
Dr Johnson
Host-pathogen interactions I
Host-pathogen interactions II
Dendritic cells I
Mon
Wed
Fri
20
22
24
“
“
“
Dr Johnson
Dr Johnson
Dr Labrecque
Dendritic cells II
Dendritic cells III
TCR/MHC interactions
Mon
Wed
Fri
27
29
1
“
“
October
Dr Darlington
Dr Darlington
Dr Darlington
Polyspecificity of T cell receptor recognition
Polyspecificity of T cell receptor recognition
Molecular mimicry and epitope spreading
Mon
Wed
Fri
4
6
8
“
“
“
Dr Newkirk
Dr Fournier
--------------
Autoantibodies
OPEN DISCUSSION
-----------------------------
Mon
Wed
Fri
11
13
15
“
“
“
THANKSGIVING DAY
MID-TERM EXAM
Dr Fournier
Mid-term exam revision/ Term paper
Mon
18
“
Dr Dzierszinski
Wed
20
“
Dr Dzierszinski
Fri
22
“
Dr Fritz
Mon
25
“
Dr Fritz
Wed
27
“
Dr Fritz
Fri
29
“
Dr Fournier
Subversion of the host immune responses by
intracellular parasites I
Subversion of the host immune responses by
intracellular parasites II
Innate immune recognition through
Nod-like receptors I
Innate immune recognition through
Nod-like receptors II
Innate immune recognition through
Nod-like receptors III
The B7/CD28/CTLA-4 pathway I
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MIMM 414, 2010
Mon
Wed
1
3
November
“
Dr Fournier
Dr Suh
The B7/CD28/CTLA-4 pathway II
The extended CD28-B7 family I
Fri
5
“
Dr Suh
The extended CD28-B7 family II
Mon
Wed
Fri
8
10
12
“
“
“
Dr Piccirillo
Dr Piccirillo
Dr Piccirillo
Peripheral tolerance
Regulatory lymphocytes I
Regulatory lymphocytes II
Mon
Wed
Fri
15
17
19
“
“
“
Dr Bar-Or
Dr Bar-Or
Dr Bar-Or
Cytokines in immune regulation
B cells as immune regulators
Autoimmunity: Lessons from Experimental
Therapies and Special Cohorts
Mon
Wed
Fri
22
24
26
“
“
“
Dr Fournier
Dr Fournier
Dr Zhang
T cell memory I
T cell memory II
Blood Brain Barrier-Interface between the
immune system and the nervous system
Mon
29
“
Dr Zhang
Wend 1
December
Dr Zhang
Fri
“
Dr Fournier
Macrophages and Microglia:
Biology and Function
Neuroimmune interaction in
neurodegenerative diseases.
OPEN DISCUSSION
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Evaluation:
 Mid-Term Exam, Wednesday, October 13 (1h, 2 to 3 essay-type questions)
Will cover material from the start-up to and including October 4.
20%
 Final Examination,
(3h, 6 essay-type questions) 50%
Will cover all material, with more emphasis on material given after October 4.
 Term paper
30%
A detailed examination of a topic in immunology, based on recent publications.
15 pages
The choice of the publication must be approved by the course coordinator (Dr. Fournier).
Deadline for selection of the publication:
October 29
Deadline for submission of the term paper:
November 19
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MIMM 414, 2010
In accord with McGill University’s Charter of Students’ Rights, students in this course have the
right to submit in English or in French any written work that is to be graded.
McGill University values academic integrity. Therefore all students must understand the
meaning and consequences of cheating, plagiarism and other academic offences under the Code
of Student Conduct and Disciplinary Procedures (see www.mcgill.ca/students/srr/honest/
<http://www.mcgill.ca/students/srr/honest/> ) for more information).
L'université McGill attache une haute importance à l’honnêteté académique. Il incombe par
conséquent à tous les étudiants de comprendre ce que l'on entend par tricherie, plagiat et autres
infractions académiques, ainsi que les conséquences que peuvent avoir de telles actions, selon le
Code de conduite de l'étudiant et des procédures disciplinaires (pour de plus amples
renseignements, veuillez consulter le site www.mcgill.ca/students/srr/honest/
<http://www.mcgill.ca/students/srr/honest/> ).
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