Migrænikerforbundet, 14. juli 2009
Udtræk fra PubMed 14. juli 2009, med søgeordene 'aspartame' og
'migraine'. Fem ud af 14 artikler konkluderede, at der er personer, som
får eller formentlig får migræne af aspartam.
Clin J Pain. 2009 Jun;25(5):446-52.
Foods and supplements in the management of migraine headaches.
Sun-Edelstein C, Mauskop A.
The New York Headache Center, New York, NY 10021, USA. drsun@nyheadache.com
OBJECTIVE: Although a wide range of acute and preventative medications are now available for
the treatment of migraine headaches, many patients will not have a significant improvement in
the frequency and severity of their headaches unless lifestyle modifications are made. Also,
given the myriad side effects of traditional prescription medications, there is an increasing
demand for "natural" treatment like vitamins and supplements for common ailments such as
headaches. Here, we discuss the role of food triggers in the management of migraines, and
review the evidence for supplements in migraine treatment. METHODS: A review of the English
language literature on preclinical and clinical studies of any type on food triggers, vitamins,
supplements, and migraine headaches was conducted. RESULTS: A detailed nutritional history is
helpful in identifying food triggers. Although the data surrounding the role of certain foods and
substances in triggering headaches is controversial, certain subsets of patients may be sensitive
to phenylethylamine, tyramine, aspartame, monosodium glutamate, nitrates, nitrites, alcohol,
and caffeine. The available evidence for the efficacy of certain vitamins and supplements in
preventing migraines supports the use of these agents in the migraine treatment.
CONCLUSIONS: The identification of food triggers, with the help of food diaries, is an
inexpensive way to reduce migraine headaches. We also recommend the use of the following
supplements in the preventative treatment of migraines, in decreasing order of preference:
magnesium, Petasites hybridus, feverfew, coenzyme Q10, riboflavin, and alpha lipoic acid.
Dermatitis. 2008 May-Jun;19(3):E10-1.
Comment in:
Dermatitis. 2009 May-Jun;20(3):176-7; author reply 177-9.
Formaldehyde, aspartame, and migraines: a possible connection.
Jacob SE, Stechschulte S.
Department of Dermatology and Cutaneous Surgery, University of Miami, Miami, FL, USA.
Aspartame is a widely used artificial sweetener that has been linked to pediatric and adolescent
migraines. Upon ingestion, aspartame is broken, converted, and oxidized into formaldehyde in
various tissues. We present the first case series of aspartame-associated migraines related to
clinically relevant positive reactions to formaldehyde on patch testing.
Migrænikerforbundet, 14. juli 2009
Headache. 2001 Oct;41(9):899-901.
Migraine MLT-down: an unusual presentation of migraine in patients with aspartame-triggered
headaches.
Newman LC, Lipton RB.
The Headache Institute, St. Lukes-Roosevelt Hospital Center, 1000 Tenth Avenue, Suite 1C10, New York, NY
10019, USA.
Aspartame, an artificial sweetener added to many foods and beverages, may trigger headaches
in susceptible individuals. We report two patients with aspartame-triggered attacks in whom the
use of an aspartame-containing acute medication (Maxalt-MLT) worsened an ongoing attack of
migraine.
PMID: 11703479 [PubMed - indexed for MEDLINE]
Headache. 1997 Nov-Dec;37(10):665-6.
Chewing gum headaches.
Blumenthal HJ, Vance DA.
Department of Neurology, University of Oklahoma College of Medicine, Tulsa, USA.
Aspartame, a popular dietetic sweetener, may provoke headache in some susceptible
individuals. Herein, we describe three cases of young women with migraine who reported their
headaches could be provoked by chewing sugarless gum containing aspartame.
Headache. 1989 Feb;29(2):90-2.
Aspartame as a dietary trigger of headache.
Lipton RB, Newman LC, Cohen JS, Solomon S.
Many dietary factors have been implicated as possible precipitants of headache. There have been recent
differences of opinion with regard to the effect of the artificial sweetener aspartame as a precipitant of
headache. To assess the importance of aspartame as a dietary factor in headache, 190 consecutive
patients of the Montefiore Medical Center Headache Unit were questioned about the effect of alcohol,
carbohydrates and aspartame in triggering their headaches. Of the 171 patients who fully completed the
survey, 49.7 percent reported alcohol as a precipitating factor, compared to 8.2 percent reporting
aspartame and 2.3 percent reporting carbohydrates. Patients with migraine were significantly more likely
to report alcohol as a triggering factor and also reported aspartame as a precipitant three times more
often than those having other types of headache. The conflicting results of two recent placebo-control
Migrænikerforbundet, 14. juli 2009
studies of aspartame and headache are discussed. We conclude that aspartame may be an important
dietary trigger of headache in some people.