Angus W. MacDonald, III, PhD University of Minnesota Department of Psychology N218 Elliot Hall, 75 E. River Rd Minneapolis, Minnesota, 55455 612-624-3813 email: angus@umn.edu ___________________________________________________________________________________________ ACADEMIC APPOINTMENTS Associate Professor, University of Minnesota Assistant Professor, University of Minnesota Primary Appointment: Secondary Appointments: 2008 - present 2003 - 2008 Clinical Science and Psychopathology Research Program, Department of Psychology Cognitive and Biological Sciences Program, Dept. Psychology Personality, Individual Differences & Behavior Genetics Program, Dept. Psychology Biological Psychopathology Program, Dept. Psychology Center for Cognitive Sciences Graduate Program in Neuroscience University of Minnesota School of Medicine, Department of Psychiatry Director: Translational Research in Cognitive and Affective Mechanisms laboratory My laboratory explores questions in basic cognitive and affective neuroscience, the biological bases of psychopathology, and the measurement of group differences. Methodologies include functional magnetic resonance imaging (fMRI), behavioral genetics (twin and family studies), clinical assessment and cognitive testing. Current research includes (1) understanding how executive control mechanisms, which are associated with prefrontal cortex functioning, modulate attention, affective processing, social interactions and decision-making; (2) evaluating how impairments in such mechanisms may be related to schizophrenia and the genes associated with schizophrenia; and (3) methods development for analyzing fMRI, and psychometric confounds in the measurement of group differences. URL: www.psych.umn.edu/research/tricam/ EDUCATION Post-Doctoral Fellowship 2001-2002 Clinical Cognitive Neuroscience Laboratory Western Psychiatric Institute & Clinic, Department of Psychiatry University of Pittsburgh Medical Center Mentor: Cameron Carter, M.D. Ph.D. University of Pittsburgh Graduation Date: August 2001 Clinical Psychology Program, Department of Psychology & Center for the Neural Basis of Cognition; Clinical Internship: Western Psychiatric Institute & Clinic Co-advisors: Michael F. Pogue-Geile, Ph.D. & Cameron Carter, M.D. Dissertation Title: A differential deficit in context processing associated with the genetic liability to schizophrenia: a sibling study. B.A. Amherst College, Amherst, MA Psychology & Philosophy Majors Graduation Date: December 1990 2 AWARDS & HONORS NARSAD Sidney R. Baer, Jr. Prize for Schizophrenia Research (2008, National Alliance for Research on Schizophrenia and Depression & Sidney R. Baer, Jr. Foundation) Chronicle of Higher Education Neuroscience in Psychology: Scholar to Watch (10 December 2008) McKnight Land-Grant Professorship (2006-2008, University of Minnesota) Young Investigator Award (2005 & 2008, National Alliance for Research on Schizophrenia and Depression) Smadar Levine Award Runner Up (2001, Society for Research in Psychopathology) Bassell Award for Excellence in Psychological Research (2000, University of Pittsburgh) Travel Fellowship, Organization for Human Brain Mapping (2000) Center for the Neural Basis of Cognition Training Fellowship (1998-1999, National Science Foundation) MEMBERSHIPS IN PROFESSIONAL SOCIETIES American Psychological Association, Division 12 (Society for the Science of Clinical Psychology) Behavior Genetics Association Cognitive Neuroscience Society Minnesota Psychological Association Organization for Human Brain Mapping Society for Neuroscience Society for Research in Psychopathology GRANTS Current Grants 1. R01 National Institute of Mental Health. “Cognitive Neuroscience Task Reliability & Clinical Applications.” $260,000 direct costs. Angus MacDonald, III, Principal Investigator. Multi-site study. September 2008 – September 2011 (R01MH084861) 2. R21 National Institute of Mental Health. “Imaging the Impact of Glutamate Liability Genes in Schizophrenia.” $275,000 direct costs. A.W. MacDonald, III, Principal Investigator. February 2008 – February 2010 (R21MH079262). 3. R21 National Institute of Drug Abuse, “Neuroanatomical basis of anti-drug message processing.” $750,000 direct costs. A.W. MacDonald, III & M.C. Yzer, Principal Investigators. September 2007 – August 2010 (R21DA024430). 4. National Alliance for Research in Schizophrenia and Affective Disorders (NARSAD), Young Investigator Award. “The Neural Basis of Paranoia in Schizophrenia” $60,000 direct costs. A.W. MacDonald, III, Principal Investigator. July 2008 – June 2010. 5. P20 National Institute of Drug Abuse, “Impulsivity in Addiction.” $2,000,000 total direct costs, $200,000 direct core costs. K.O. Lim, Principle Investigator. A.W. MacDonald, III, Director of the Neurocognitive and Behavioral Core. September 2007 – June 2011. (P20DA024196) 6. Merit Review, Veteran’s Administration. “Neural Phenotype-Genotype Associations in Schizophrenia.” $799,400 total direct expenses, approx $240,000 total site specific direct costs. S.R. Sponheim, Principal Investigator, A.W. MacDonald, III, Co-Investigator and Site Project Director. April 2005 – March 2010. 7. R01 National Institute of Mental Health, “White Matter Abnormalities in Schizophrenia“ $2,434,162 total direct costs. K.O. Lim, Principal Investigator, A.W. MacDonald, III, CoInvestigator. October 2005 – September 2010. (R01MH060662) 3 8. P50 National Institute of Mental Health. “Trait fear and fearlessness in humans.” $978,848 total site specific direct costs. P. Lang, Principal Investigator, C. J. Patrick, Site Project Director, A.W. MacDonald, III, Co-Investigator. July 2005 – June 2010. (P50MH072850) Grants Pending None. Grants Completed 1. R01 National Institute of Mental Health, “Cognitive Neurogenetics of Schizophrenia.” $1,000,000 direct expenses, approx. $140,000 total site specific direct costs. C.S. Carter, Principal Investigator, A.W. MacDonald, III, Co-Investigator. December 2003 – November 2008 (R01MH066629). 2. National Alliance for Research in Schizophrenia and Affective Disorders (NARSAD), Young Investigator Award. “The Genetic and Neural Basis of Paranoia: A Functional MRI Study in Twins.” $60,000 total direct costs. A.W. MacDonald, III, Principal Investigator. July 2005 – June 2007. 3. R24 National Institute of Mental Health, “Aberrant Cortical Dynamics in Schizophrenia.” $725,000 total direct expenses, approx. $142,000 total site specific direct costs. S.R. Sponheim, Principal Investigator, A.W. MacDonald, III, Co-Investigator and Site Project Director. July 2004 – June 2007. (R24MH069675) 4. Clinical Research Feasibility Funding (CReFF). University of Minnesota General Clinical Research Center. “Changes in Cortical Activation with Cognitive Rehabilitation in Schizophrenia.” $40,000 total direct costs. A.W. MacDonald, III, Principal Investigator. December 2003 – November 2005. 5. Grant-in-Aid of Research, Artistry and Scholarship, University of Minnesota, “Advanced Methods for Dissociating Cognitive Control Mechanisms in fMRI.” $25,000 total direct costs. A.W. MacDonald, III, Principal Investigator. July 2003 – December 2005. 6. National Institutes of Health/NCRR, Biomedical Informatics Research Network (BIRN). “Functional Imaging Research in Schizophrenia Testbed – FIRST BIRN.” $1,000,000 total site specific direct costs. S.G. Potkin, Principal Investigator, K. O. Lim, Site Project Director, A.W. MacDonald, III, Co-Investigator. October 2002 – November 2005. Current and Completed Magnetic Resonance Imaging Piloting Grants (Center for Magnetic Resonance Research) 1. “Comparison of Event-Related fMRI Designs for Compound Trial-Types.” 30 pilot hours. A.W. MacDonald, III, Principal Investigator. June 2003 – May 2004. 2. “Changes in Cortical Activation with Cognitive Rehabilitation in Schizophrenia” 25 pilot hours. Angus W. MacDonald, Principal Investigator. August 2005 – January 2006. 3. “The Genetic and Neural Basis of Paranoia: A Functional MRI Study in Twins.” 30 pilot hours. A.W. MacDonald, III, Principal Investigator. July 2005-June 2007. 4. “Striatal Functioning as an Endophenotype of Schizophrenia.” 30 pilot hours. Angus W. MacDonald, III, Principal Investigator. January 2008 – January 2009. 4 5. “Genetic and Environmental Effects on Brain Structure and Function in Twins.” 10 paid + 30 pilot hours. W.G. Iacono, Principal Investigator, A.W. MacDonald, III, Co-Investigator. Feb 2003 – November 2004. 6. “Neural Mediators of Attraction, Acceptance, and Rejection.” 20 pilot hours. C. Marsolek, Principal Investigator, A.W. MacDonald, III, Co-Investigator. September 2004 – December 2005. 7. “Equilibrium of Sequential Games: an event-related fMRI Study.” 10 paid + 20 pilot hours. A. Rusticini. A.W. MacDonald, III, Co-Investigator. September 2004 – September 2005. 8. “Neural Substrates of Impaired Vigilance in Siblings of Schizophrenia Patients.” 20 pilot hours. S.R. Sponheim, Principal Investigator, Angus W. MacDonald, III, Co-Investigator. October 2004 – September 2005. 9. “Neural Basis of Abstract Spatial Processing in Human Cortex.” 27 pilot hours. Chafee, M., Principal Investigator, Angus W. MacDonald, III, Co-Investigator. January 2005 – July 2005. 10. “Neural Activation Associated with the Contextual Processing of Spatial Information in Schizophrenia.” 30 pilot hours. S.R. Sponheim, Principal Investigator, Angus W. MacDonald, III, Co-Investigator. October 2007 – March 2008. 11. “Decoding Maintenance and Conflict Signals in Prefrontal and Parietal Cortices.” 30 pilot hours. Chafee, M., Principal Investigator, Angus W. MacDonald, III, Co-Investigator. March 2008 – February 2009. PUBLICATIONS Peer-reviewed Journal Articles (* indicates student/trainee first author) 1. Harrow, M., MacDonald, A.W., III, Sands, J.R., & Silverstein, M.L. (1995). Vulnerability to delusions over time in schizophrenia, schizoaffective and bipolar and unipolar affective disorders: A multi-follow-up assessment. Schizophrenia Bulletin, 21, 95-109. 2. August, G.A., Realmuto, G.M., Crosby, R.D., & MacDonald, A.W., III (1995). Community-based multiple-gate screening of children at-risk for conduct disorder. Journal of Abnormal Child Psychology, 23, 521-544. 3. August, G.A., Realmuto, G.M., MacDonald, A.W., III, Nugent, S.M., & Crosby, R. (1996). Prevalence of ADHD and comorbid disorders among elementary school children screened for disruptive behavior. Journal of Abnormal Child Psychology, 24, 571-595. 4. August, G.A., MacDonald, A.W., III, Realmuto, G.M., & Skare, S.S. (1996). Hyperactive and aggressive pathways: effects of demographic, family and child characteristics on children’s adaptive functioning. Journal of Clinical Child Psychology, 25, 341-351. 5. Carter, C.S., MacDonald, A.W., III, Botvinick, M., Ross, L.L., Stenger, V.A., Noll, D. & Cohen, J.D. (2000). Parsing executive processes: strategic versus evaluative functions of the anterior cingulate cortex. Proceedings of the National Academy of Sciences, 97, 1944-1948. 6. Aizenstein, H.J., MacDonald, A.W., III, Stenger, V.A., Larson, J.K., Ursu, S., Nebes, R.D., Carter, C.S. (2000). Complementary category learning systems identified using event-related fMRI. Journal of Cognitive Neuroscience, 12, 977-987. 5 7. MacDonald, A.W., III, Cohen, J.D., Stenger, V.A., & Carter, C.S. (2000). Dissociating the role of the dorsolateral prefrontal cortex and anterior cingulate cortex in cognitive control. Science, 288, 1835-1838. 8. Barch, D.B., Carter, C.S., Sabb, F.W., MacDonald, A.W., III, Noll, D.C., Braver, T.S., & Cohen, J.D. (2001). Selective deficits in pre-frontal cortex function in medication - naive patients with schizophrenia. Archives of General Psychiatry, 58, 280-288. 9. MacDonald, A.W., III, Pogue-Geile, M.F., Debski, T.T., & Manuck, S. (2001). Genetic and environmental influences on schizotypy: A community-based twin study. Schizophrenia Bulletin, 27, 47-58. 10. Carter, C.S., MacDonald, A.W., III, Ross, L.L., Stenger, V.A. (2001). Anterior cingulate cortex and impaired self-monitoring of performance in schizophrenia: an event-related fMRI study. American Journal of Psychiatry, 158, 1423-1428. 11. MacDonald, A.W., III, & Carter, C.S. (2002). Cognitive experimental approaches to investigating impaired cognition in schizophrenia: a paradigm shift. Journal of Experimental and Clinical Neuropsychology, 24, 873-882. 12. Barch, D.M., Carter, C.S, MacDonald, A.W., III, Braver, T.S., Cohen, J.D. (2003). Context processing deficits in schizophrenia: diagnostic specificity, four-week course, and relationship to clinical symptoms. Journal of Abnormal Psychology, 112, 132-143. 13. MacDonald, A.W., III, Pogue-Geile, M.F, Johnson, M.K. & Carter, C.S (2003). A specific deficit in context processing in the unaffected siblings of patients with schizophrenia. Archives of General Psychiatry, 60, 57-65. 14. MacDonald, A.W., III, & Carter, C.S. (2003). Event-related fMRI study of context processing in the dorsolateral prefrontal cortex of patients with schizophrenia. Journal of Abnormal Psychology, 112, 689-697. 15. Kerns, J.G., Cohen, J.D., MacDonald, A.W., III, Cho, R.Y., Stenger, V.A., & Carter, C.S. (2004). Anterior cingulate conflict monitoring and adjustments in control. Science, 303, 1023-1026. 16. Holmes, A.J.*, MacDonald, A.W., III, Carter, C.S., Barch, D.M., Stenger, V.A., Cohen, J.D. (2005). Prefrontal functioning during context processing in schizophrenia and major depression: an event-related fMRI study. Schizophrenia Research, 76, 199-206. 17. MacDonald, A.W., III, Carter, C.S., Kerns, J.G., Ursu, S., Barch, D., Holmes, A.J., Stenger, V.A, & Cohen, J.D. (2005). Specificity of prefrontal dysfunction and context processing deficits to schizophrenia in an unmedicated first-episode psychotic sample. American Journal of Psychiatry, 162, 475-484. 18. Kerns, J.G., Cohen, J.D., MacDonald, A.W, III, Johnson, M.K., Stenger, V.A., Aizenstein, H.J., Carter, C.S. (2005). Decreased conflict and error-related activity in the anterior cingulate cortex in schizophrenia. American Journal of Psychiatry, 162, 1833-1839. 19. Snitz, B.E., MacDonald, A.W., III, Cohen, J.D., Becker, T., Carter, C.S. (2005). Lateral and medial hypofrontality in first-episode schizophrenia: Functional activity in a medication-naïve state and effects of short-term atypical antipsychotic treatment. American Journal of Psychiatry, 162, 2322-2329. 6 20. MacDonald, A.W., III, Goghari, V.M., Hicks, B.M., Flory, J.D., Carter, C.S., Manuck, S.B. (2005). A convergent-divergent approach to context processing, general intellectual, functioning, and the genetic liability to schizophrenia. Neuropsychology, 19, 814-821. 21. Snitz, B.E., MacDonald, A.W., III, Carter, C.S. (2006). Cognitive deficits in unaffected firstdegree relatives of schizophrenia patients: A meta-analytic review of putative endophenotypes. Schizophrenia Bulletin, 32, 179-194. 22. MacDonald, A.W., III, Becker, T.M., Carter, C.S. (2006). Functional magnetic resonance imaging study of cognitive control in the healthy relatives of schizophrenia patients. Biological Psychiatry, 60, 1241-1249. 23. Brambilla, P., MacDonald, A.W., III, Sassi, R.B., Johnson, M.K., Mallinger, A.G., Carter, C.S., & Soares, J.C. (2007). Context processing performance in bipolar disorder patients. Bipolar Disorders, 9, 230-237. 24. Goghari, V.M.*, Rehm, K., Carter, C.S., MacDonald, A.W., III (2007). Regionally specific cortical thinning and grey matter abnormalities in the healthy relatives of schizophrenia patients. Cerebral Cortex, 17, 415-424. 25. MacDonald, A.W., III, Carter, C.S., Flory, J.D., Ferrell, R.E., Manuck, S.B. (2007). COMT Val158Met and executive control: a test of the benefit of specific deficits to translational research. Journal of Abnormal Psychology, 116, 306-312. 26. Goghari, V.M.*, Rehm, K., Carter, C.S., MacDonald, A.W., III (2007). Sulcal thickness as a vulnerability indicator for schizophrenia. British Journal of Psychiatry, 191, 229-233. 27. Goghari, V.M.* & MacDonald, A.W., III (2008). Effects of varying the experimental design of a cognitive control paradigm on behavioral and functional imaging outcome measures. Journal of Cognitive Neuroscience, 20, 20-35. 28. Becker, T.M.*, Kerns, J.G., MacDonald, A.W., III, Carter, C.S. (2008). Prefrontal dysfunction in first-degree relatives of schizophrenia patients during a Stroop task. Neuropsychopharmacology. doi:10.1038/sj.npp.1301673. 29. MacDonald, A.W., III (2008). Building a clinically-relevant cognitive task: Case study of the AX paradigm. Schizophrenia Bulletin. doi:10.1093/schbul/sbn038. 30. MacDonald, A.W., III, Thermenos, H.W., Barch, D.M., & Seidman, L.J. (2008). Imaging genetic liability to schizophrenia: A systematic review of fMRI studies of patients’ non-psychotic relatives. Schizophrenia Bulletin. doi:10.1093/schbul/sbn053. 31. Barch, D.M., Berman, M.G., Engle R., Jones, J.H., Jonides, J., MacDonald, A.W., III, Nee, D.E., Redick, T.S., Sponheim, S.R. (2009). CNTRICS final task selection: working memory. Schizophrenia Bulletin, 35, 136-152. 32. MacDonald, A.W., III & Kang, S.S. (in press). Misinterpreting schizophrenia relatives’ impairments. American Journal of Human Genetics B: Neuropsychiatric Genetics. 33. Johnson, M.K.*, Rustichini, A., MacDonald, A.W., III (in press). Suspicious personality predicts behavior on a social decision-making task. Personality and Individual Differences. 34. MacDonald, A.W., III & Schulz, S.C. (in press). What we know: findings that every theory of schizophrenia should explain. Schizophrenia Bulletin. 7 Invited Journal Articles, Commentaries & Chapters (* indicates student/trainee first author) 1. MacDonald, A.W., III. (2003). Reconciling schizophrenic deficits in top-down and bottom-up processes -- not yet. Brain and Behavior Sciences, 26, 96. 2. Krueger, R.F., & MacDonald, A.W., III (2005). Dimensional approaches to understanding and treating psychosis. Psychiatric Annals, 35, 31-35. 3. MacDonald, A.W., III, & Iacono, W.G. (2006). Toward an integrated etiology of psychopathy. In C.J. Patrick (Ed.), Handbook of Psychopathy. New York: Guilford Press. pp. 375-385. 4. MacDonald, A.W., III, & Chafee, M.V. (2006). Translational and developmental perspective on NMDA synaptic deficits in schizophrenia. Development & Psychopathology. 18, 853-876. 5. MacDonald, A.W., III, & Kang, S.S. (2007). Cassandra’s calculations: simulation studies of the psychometric confound. In D.P. French (Ed.), Schizophrenic Psychology: New Research. Hauppauge, NY: Nova Science Publishers, Inc. pp. 281-301. 6. Kang, S.S.*, MacDonald, A.W., III (2007). Measuring discriminating power: beyond true-score variance. In R.A. Degregorio (Ed.), New Developments in Psychological Testing. Hauppauge, NY: Nova Science Publishers, Inc. pp. 91-117. 7. MacDonald, A.W., III (in press). A sneaking suspicion: The semantics of emotional beliefs and delusions. Commentary on Rogers & McClelland (2008). Brain and Behavior Sciences. 8. MacDonald, A.W., III, & Jones, J.H. (in press). Functional imaging in clinical assessment? The rise of neurodiagnostics. In J. Butcher (Ed.), Oxford Handbook of Personality Assessment. Oxford University Press. 9. MacDonald, A.W., III. (in press). Is more cognitive experimental psychopathology of schizophrenia really necessary? Challenges and opportunities. In M. Ristner (Ed.), Neuropsychiatric Biomarkers, Endophenotypes, and Genes: Promises, Advances and Challenges. Springer. Journal Articles Submitted for Peer Review (* indicates student/trainee first author) 1. Haut, K.M.*, Lim, K.O., MacDonald, A.W., III (submitted). Prefrontal cortical changes following cognitive training in patients with schizophrenia: effects of practice, generalization and specificity. 2. Jones, J.A.H., Sponhein, S.R., MacDonald, A.W., III (submitted). The dot pattern expectancy (DPX) task: reliability and replication of deficits in schizophrenia. 3. Goghari, V.*, MacDonald, A.W., III (submitted). The neural basis of cognitive control: response selection and inhibition. 4. Haut, K.M.*, MacDonald, A.W., III (under revision). Persecutory delusions and the perception of trustworthiness in unfamiliar faces in schizophrenia. 5. Beckes, L.*, Marsolek, C.J., & MacDonald, A.W., III (under revision). Social acceptance increases the attractiveness and reward value of beautiful faces. Guest Edited Journals 8 1. Schizophrenia Bulletin, Special Theme Issue on Theories of Schizophrenia: Explanatory Power and Inferential Strength. Scheduled publication May 2009. Published Abstracts (* indicates student/trainee first author) 1. Harrow, M., Andres, B., MacDonald, A.W., III, Silverstein, M.L., & Sands, J. (1992) Delusions and hallucinations: schizophrenic traits? Proceedings of the 145th Annual Meeting of the American Psychiatric Association, 82. American Psychiatric Association: Washington, D.C. 2. Harrow, M., MacDonald, A.W., III, Sands, J.R., & Silverstein, M.L. (1993). Vulnerability to delusions and hallucinations in schizophrenia and affective disorders. Proceedings of the 101st Annual Meeting of the American Psychological Association. American Psychological Association: Washington, D.C. 3. MacDonald, A.W., III, Pogue-Geile, M.F., Manuck, S.B., Debski, T.T. (1996). Schizotypy and neuropsychological functioning: multivariate structure in twins. Behavior Genetics, 26, 591. 4. Pogue-Geile, M.F., Ferrell, R., Deka, R., Debski, T.T., Hall, J., MacDonald, A.W., III, & Manuck, S.B. (1997). Neuropsychological functioning and dopamine D4 receptor polymorphisms: a twin and genetic association study. Neuropsychiatric Genetics, 74, 627. 5. Ross, L.L., Barch, D.B., Cohen, J.D., MacDonald, A.W., III, Noll, D., Stenger, A., & Carter, C.S. (1999). Anterior cingulate cortex dysfunction and cognitive disability in schizophrenia. Journal of Cognitive Neuroscience, suppl., 62. 6. Carter, C.S., MacDonald, A.W., III, Stenger, A., Noll, D., Cohen, J.D. (1999). Event-related fMRI of strategic vs. evaluative functions of the anterior cingulate during cognition. Journal of Cognitive Neuroscience, suppl., 63. 7. MacDonald, A.W., III, Perlstein, W.M., Chein, J., Feiz, J., Noll, D., & Carter, C.S. (1999). An fMRI study of individual differences in working memory capacity in the N-back task. Journal of Cognitive Neuroscience, suppl., 34. 8. Carter, C.S., Barch, D.B., MacDonald, A.W., III, Noll, D., Stenger, A. & Cohen, J.D. (1999). Anterior cingulate and cognitive disability in schizophrenia: an event-related fMRI study. Schizophrenia Research, 36, 219-220. 9. Barch, D.M., Carter, C.S., MacDonald, A.W., III, Sabb, F.W., Noll, D., & Cohen, J.D. (1999). Prefrontal cortex and context processing in medication-naive first-episode patients with schizophrenia. Schizophrenia Research, 36, 217-218 10. Aizenstein, H.J., MacDonald, A.W., III, Stenger, V.A., Larson, J.K., Ursu, S., Nebes, R.D., Carter, C.S. (1999). Complementary category learning systems identified using event-related fMRI. Society for Neuroscience Abstracts, v. 25, pt I, 1289. Society for Neuroscience: Washington, D.C. 11. Carter, C.S., MacDonald, A.W., III, Botvinick, M.M., Stenger, A., & Cohen, J.D. (1999). Anterior cingulate cortex and executive control: what is it really doing? Society for Neuroscience Abstracts, v. 25, pt II, 2168. Society for Neuroscience: Washington, D.C. 12. MacDonald, A.W., III, Cohen, J.D., Stenger, V.A., & Carter, C.S. (2000). Dissociating control processes of dorsolateral prefrontal cortex and anterior cingulate cortex with fMRI and the Stroop task. Journal of Cognitive Neuroscience, suppl., 111. 9 13. MacDonald, A.W., III, Pogue-Geile, M.F., Thompson, J.L., Ross, L.R., Allen, T., Johnson, M.K., Lollo, N.D., Marquetter, A.R., Yablonski, E.J., & Caster, C.S. (2000). Differential deficit in working memory, not attention, associated with liability to schizophrenia: a sibling study of the expectancy AX-CPT. Behavior Genetics, 30, 411. 14. MacDonald, A.W., III, Cohen, J.D., Stenger, V.A., & Carter, C.S. (2000). Functional double dissociation of dorsolateral prefrontal cortex and anterior cingulate cortex in cognitive control. Neuroimage, 11, S1. 15. Carter, C.S., MacDonald, A.W., III, Ursu, S., & Stenger, V.A. (2000). Functional specialization within the frontal-parietal network supporting executive control. Society for Neuroscience Abstracts, v. 26, pt I, 550. Society for Neuroscience: Washington, D.C. 16. MacDonald, A.W., III, Ross, L.L., Becker,, J., & Carter, C.S. (2000). Attentional control processes in DLPFC: domain specific or domain general? Society for Neuroscience Abstracts, v. 26, pt I, 550. Society for Neuroscience: Washington, D.C. 17. Carter, C.S., Barch, D.M., MacDonald, A.W., III, Ursu, S. & Cohen, J.D. (2001). Prefrontalrelated impairments in cognitive control are not specific to schizophrenia. Schizophrenia Research, 49, 175. 18. MacDonald, A.W., III, Pogue-Geile, M.F., & Carter, C.S. (2001). Differential deficits in selective attention and working memory processes in the siblings of patients with schizophrenia. Schizophrenia Research, 49, 73. 19. Cho, R.Y, Cohen, J.D., van Veen, V., MacDonald, A.W., III, Kerns, J., Kriley, C. & Carter, C.S. (2002). Anterior cingulate correlates of trial-to-trial performance impairments in schizophrenia. Program No. 521.4. 2002 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience. CD-ROM. 20. MacDonald, A.W., III, Stenger, V.A., & Carter, C.S. (2002). Prefrontal cortical dysfunction and context processing deficits in unmedicated first-episode schizophrenia patients and their unaffected relatives: an event-related fMRI study. Program No. 521.2. 2002 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience. CD-ROM. 21. Cho, R.Y., Cohen, J.D., van Veen, V., MacDonald, A.W., III, Kerns, J.G., Konecky, R., Belanger, C., & Carter, C.S. (2003). A multimodal examination of anterior cingulate cortex correlations from trial-to-trial performance impairments in schizophrenia. Schizophrenia Research, 60, 215. 22. Holmes, A.J., MacDonald, A.W., III, Carter, C.S., Barch, D.M., Stenger, V.A., & Cohen, J.D. (2003). The specificity of context processing deficits associated with hypofrontality in schizophrenic patients: an event-related fMRI study. Schizophrenia Research, 60, 222. 23. Becker, T.M., MacDonald, A.W., III, Pogue-Geile, M.F., & Carter, C.S. (2003). Demonstration of a differential deficit: empirical validation of psychometric principles using schizophrenia patients’ performance on working memory tasks. Schizophrenia Research, 60, 165. 24. Kerns, J.G., MacDonald, A.W., III, Barch, D.M., Holmes, A.J., Cohen, J.D. & Carter, C.S. (2003). Context processing deficits and decreased prefrontal cortex activity: specific associations with unmedicated, first-episode schizophrenia and with disorganization symptoms. Schizophrenia Research, 60, 228. 25. Snitz, B.E., MacDonald, A.W., III, & Carter, C.S. (2003). Cognitive impairments in adult firstdegree relatives of schizophrenia patients: a meta-analytic review. Schizophrenia Research, 60, 10 158. 26. Carter, C.S., MacDonald, A.W., III, Holmes, A.J., & Stenger, V.A. (2003). Prospective longitudinal fMRI study of prefrontal cortex based context processing in never medicated firstepisode schizophrenia. Schizophrenia Research, 60, 214. 27. MacDonald, A.W., III, Johnson, M.K., Becker, T.M. & Carter, C.S. (2003). Context processing deficits associated with hypofrontality in the healthy relatives of schizophrenia patients: an eventrelated fMRI study. Schizophrenia Research, 60, 228. 28. Goghari, V.,* Rehm, K., Carter, C.S., & MacDonald, A.W., III (2005). MRI of prefrontal cortex in the healthy relatives of schizophrenia patients and controls. Schizophrenia Bulletin, 31, 389-390. 29. Haut, K.* & MacDonald, A.W., III (2005). Persecutory delusions and the perception of trustworthy faces in schizophrenia. Schizophrenia Bulletin, 31, 358. 30. Johnson, M.K.,* Rusticini, A., & MacDonald, A.W., III (2005). Effects of paranoid-spectrum personality on social decision-making. Schizophrenia Bulletin, 31, 368. 31. Goghari V.M.,* Rehm K., Carter C.S., MacDonald A.W., III. (2005). Prefrontal cortex structure in the healthy relatives of schizophrenia patients and controls. NeuroImage, 26, CD-ROM. 32. Goghari, V.M.,* Johnson, M.K., & MacDonald, A.W., III. (2005). Efficient acquisition of paired events in fMRI: Comparison of techniques across a cognitive control paradigm. Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience. CD-ROM. 33. Hurdelbrink, J.A.,* Sponheim, S.R., Goghari, V., & MacDonald, A.W., III (March 2007). Electrophysiological components of context processing deficits in schizophrenia. Schizophrenia Bulletin, 33, 406. 34. Kang, S.S.,* Sponheim, S.R., Im, C., Force, R.B., Stanwyck, J.J., Chafee, M.V., & MacDonald, A.W., III (March 2007). Aberrant cerebral magnetic fields and hemodynamic signals in schizophrenia during controlled processing in spatial working memory. Schizophrenia Bulletin, 33, 372. 35. Johnson, M.K.,* Walter, R., Carter, C.S., & MacDonald, A.W., III (2007). Dissociating the neural basis of suspiciousness from rational mistrust and risk aversion: an fMRI study of the Minnesota Trust Game. Schizophrenia Bulletin, 33, 372. 36. Haut, K.M.,* Johnson, M.K., Hegeman, B.M., Goghari, V.M., & MacDonald, A.W., III (2007). Cognitive remediation and changes in prefrontal cortical function in schizophrenia: behavioral vs. functional sensitivity to change. Schizophrenia Bulletin, 33, 370. 37. Lim, K.O., Mueller, B.A., Wozniak, J.R., Olson, S., & MacDonald, A.W., III (2007). Comparison of in vivo magnetic resonance methods for examining white matter abnormalities in schizophrenia. Schizophrenia Bulletin, 33, 343. 38. MacDonald, A.W., III, Johnson, M.K., Porter, J.N., & Krueger, R.F. (2007). Persecutory ideation: experimental findings & functional neuroanatomy in concordant and discordant twins. Schizophrenia Bulletin, 33, 377. 39. Haut, K.M.,* MacDonald, A.W., III (2007). Test-retest reliability of working memory fMRI activation. Neuroimage, 36, Suppl 1, CD/ROM. 11 40. Goghari, V.M.* & MacDonald, A.W., III (2007). Increased anterior cingulate activity when switching a cognitive but not a motoric response. Neuroimage, 36, Suppl 1, CD/ROM. 41. Beckes, L.*, Marsolek, C., & MacDonald, A.W., III (2007). Neural mediators of attraction, acceptance, and rejection. Neuroimage, 36, Suppl 1, CD/ROM. 42. Haut, K.M.,* Prom, M., & MacDonald, A.W., III (2008). Test-retest reliability of functional activation in schizophrenia and unaffected individuals during working memory tasks: differences, implications, and the effects of denoising. Neuroimage, 37, Suppl 1, CD/ROM. Other Publications MacDonald, A.W., III. (1995, May). Green passage beyond human words. Shambala Sun, 22-27. PRESENTATIONS Invited Addresses, Symposia, Colloquia 1. “A cognitive neuroscience approach to schizophrenia.” Invited presentation at the National Alliance for Mental Illness Research Dinner. Roseville, MN, 15 February 2005. 2. “Neuroimaging perspective on cognitive control and the genes that cause schizophrenia.” Invited presentation at University of Michigan fMRI Laboratory Speaker Series. Ann Arbor, MI, 8 December 2005. 3. “A cognitive perspective on the relationship between prefrontal cortex and schizophrenia.” Invited presentation at Grand Rounds, Department of Neurology, University of Minnesota School of Medicine, Minneapolis, MN, March 2006. 4. “Imaging risky decisions with human and non-human partners.” Invited presentation at Graduate Program for Neuroscience, University of Minnesota School of Medicine, Minneapolis, MN, 2 October 2006. 5. “Suckers: the structural, cognitive, and neuroanatomical basis of trust and suspiciousness.” Invited presentation at the University of Minnesota Carlson School of Management, Department of Marketing Friday Series, Minneapolis, MN, 27 April 2007. 6. “Mending the broken brain: pathways toward rehabilitation in schizophrenia.” Invited presentation at the 8th Annual Psychiatry Review, University of Minnesota Department of Psychiatry, Minneapolis, MN, 17 September 2007. 7. "Coming to the wall: Is more experimental psychopathology of schizophrenia necessary?" Presentation part of the "Is cognition still relevant for schizophrenia research?" Symposium at the Annual Meeting of the Society for Research in Psychopathology, St. Louis, MO, 4 October 2007. A. W. MacDonald, III, Symposium organizer. 8. “How the brain responds to cognitive rehabilitation.” Invited presentation at the International Congress of Schizophrenia Research Translational meeting, Minneapolis, MN, 6 October 2008. 9. “Attentional control deficits in schizophrenia: Implications for glutamate, dopamine and neuromigration theories.” Invited presentation at the Mt. Sinai Satellite Symposium on Cognition in Schizophrenia. San Diego, CA, 28 March 2009. 12 10. “The rough ride of experimental paradigms: From hypothesis testing in undergraduates to clinical application.” Invited presentation as part of the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS): Motivation, Results, and Next Steps symposium at the International Congress on Schizophrenia Research, San Diego, CA, 29 March 2009. 11. “Body of knowledge: the purposes, approaches and outcome of appraising What We Know about schizophrenia.” Workshop at the International Congress on Schizophrenia Research, San Diego, CA, 29 March 2009. A. W. MacDonald, III, symposium organizer. Webcast in collaboration with Schizophrenia Research Forum and the National Association for Research in Schizophrenia and Affective Disorders. 12. “Plasticity in the prefrontal cortex of schizophrenia patients undergoing cognitive training: stronger networks or alternative strategies?” Invited presentation at the 12th Annual Conference on Cognitive Remediation in Psychiatry, New York City, 5 June 2009. 13. “Role of medial PFC activation differences in MZ twins discordant for persecutory personality traits.” Invited presentation at the Association for Research in Personality, Evanston, IL, 17 July 2009. Colin DeYoung, symposium organizer. Conference Presentations in addition to published abstracts, above (* indicates student/trainee firstauthors) 1. Harrow, M., Andres, B., MacDonald, A.W., III, Silverstein, M.L., & Sands, J. (October, 1992) Delusions and hallucinations: schizophrenic traits? Presented at the 145th Annual Meeting of the American Psychiatric Association, San Francisco, CA. 2. Harrow, M., MacDonald, A.W., III, Butz, C., Sands J.R., & Silverstein, M.L. (November 1992). Bipolar and unipolar affective disorders: vulnerability to subsequent delusions. Presented at the 7th Annual Meeting of the Society for Research in Psychopathology, Palm Springs, CA. 3. Harrow, M., MacDonald, A.W., III, Sands, J.R., & Silverstein, M.L. (August 1993). Vulnerability to delusions and hallucinations in schizophrenia and affective disorders. Presented at the 101st Annual Meeting of the American Psychological Association, Toronto, ON, Canada. 4. MacDonald, A.W., III, Frazer, M., August, G.A., & Realmuto, G.M. (April 1994). Family protective factors associated with socio-emotional adjustment in children with behavior problems. Presented at the 2nd Annual Research Symposium on Child and Family Issues, Fargo, ND. 5. MacDonald, A.W., III, & Harrow, M. (May 1994). Prognostic significance of delusions and hallucinations in schizophrenia and affective disorders. Presented at the 66th Annual Meeting of the Midwest Psychological Association, Chicago, IL. 6. MacDonald, A.W., III, Skare, S.S., & August, G.A. (April 1995). Early hyperactive versus aggressive behavior: a comparison of the risks to prosocial functioning. Poster presented at the Biennial Meeting of the Society for Research in Child Development, Indianapolis, IN. 7. MacDonald, A.W., III, Pogue-Geile, M.F., Manuck, S.B., Debski, T.T. (June 1996). Schizotypy and neuropsychological functioning: multivariate structure in twins. Poster presented at the 26th annual meeting of the Behavior Genetics Association. Pittsburgh, PA. 8. MacDonald, A.W., III, Pogue-Geile, M.F., Manuck, S.B., & Debski, T.T. (September 1996). Is schizotypy related to neuropsychological deficits? A multivariate analysis in twins. Poster presented at the 11th Annual Meeting of the Society for Research in Psychopathology. Atlanta, GA. 13 9. Pogue-Geile, M.F., Ferrell, R., Deka, R., Debski, T.T., Hall, J., MacDonald, A.W., III, & Manuck, S.B. (October 1997). Neuropsychological functioning and dopamine D4 receptor polymorphisms: a twin and genetic association study. Presented at the World Congress of Psychiatric Genetics. Santa Fe, New Mexico. 10. MacDonald, A.W., III, & Pogue-Geile, M.F. (July 1998). Models of the persistence of genetic variability and the transmission of risk for schizophrenia. Poster presented at the 10th Annual Meeting of the Human Behavior and Evolution Society. Davis, CA. 11. Pogue-Geile, M., Ferrell, R., Deka, R., Debski, T., Hall, J., MacDonald, A.W., III, & Manuck, S. (November 1998). Cognitive functioning and dopamine D4 receptor polymorphisms: A twin and genetic association study. Poster presented at the 13th Annual Meeting of the Society for Research in Psychopathology. Cambridge, MA. 12. Lourea, B., Pogue-Geile, M.F. & MacDonald, A.W., III (November 1998). Genetic liability to schizophrenia and dopamine activity: a family study of schizophrenia and eye-blink rate. Poster presented at the 13th Annual Meeting of the Society for Research in Psychopathology. Cambridge, MA. 13. MacDonald, A.W., III, Pogue-Geile, M.F., & Gaulin, S. (November 1998). Population genetic perspectives on the persistence of schizophrenia. Poster presented at the 13th Annual Meeting of the Society for Research in Psychopathology. Cambridge, MA. 14. Ross, L.L., Barch, D.B., Cohen, J.D., MacDonald, A.W., III, Noll, D., Stenger, A., & Carter, C.S. (April 1999). Anterior cingulate cortex dysfunction and cognitive disability in schizophrenia. Poster presented at the Cognitive Neuroscience Society Annual Meeting. Washington, D.C. 15. Carter, C.S., MacDonald, A.W., III, Stenger, A., Noll, D., Cohen, J.D. (April 1999). Event-related fMRI of strategic vs. evaluative functions of the anterior cingulate during cognition. Poster presented at the Cognitive Neuroscience Society Annual Meeting. Washington, D.C. 16. MacDonald, A.W., III, Perlstein, W.M., Chein, J., Feiz, J., Noll, D., & Carter, C.S. (April 1999). An fMRI study of individual differences in working memory capacity in the N-back task. Poster presented at the Cognitive Neuroscience Society Annual Meeting. Washington, D.C. 17. Carter, C.S., Barch, D.B., MacDonald, A.W., III, Noll, D., Stenger, A. & Cohen, J.D. (April 1999). Anterior cingulate and cognitive disability in schizophrenia: an event-related fMRI study. Presented at the 7th International Congress on Schizophrenia Research. Santa Fe, NM. 18. Barch, D.M., Carter, C.S., MacDonald, A.W., III, Sabb, F.W., Noll, D., & Cohen, J.D. (April 1999). Prefrontal cortex and context processing in medication-naive first-episode patients with schizophrenia. Presented at the 7th International Congress on Schizophrenia Research. Santa Fe, NM. 19. Carter, C.S., Barch, D.B., MacDonald, A.W., III, Ross, L.L., Noll, D., Stenger, A. & Cohen, J.D. (May 1999). Anterior cingulate cortex and cognitive disability in schizophrenia. Presented at the Annual Meeting of the Society of Biological Psychiatry. Washington, D.C. 20. Carter, C.S., MacDonald, A.W., III, Stenger, A., Noll, D. & Cohen, J.D. (May 1999). Strategic versus evaluative functions of the anterior cingulate during cognition. Presented at the Annual Meeting of the Society of Biological Psychiatry. Washington, D.C. 14 21. Aizenstein, H.J., MacDonald, A.W., III, Stenger, V.A., Larson, J.K., Ursu, S., Nebes, R.D., Carter, C.S. (October 1999). Complementary category learning systems identified using event-related fMRI. Presented at the 29th Annual Meeting of the Society for Neuroscience, Miami Beach, FL. 22. Carter, C.S., MacDonald, A.W., III, Botvinick, M.M., Stenger, A., & Cohen, J.D. (October 1999). Anterior cingulate cortex and executive control: what is it really doing? Poster presented at the 29th Annual Meeting of the Society for Neuroscience, Miami Beach, FL. 23. MacDonald, A.W., III, Cohen, J.D., Stenger, V.A., & Carter, C.S. (April 2000). Dissociating control processes of dorsolateral prefrontal cortex and anterior cingulate cortex with fMRI and the Stroop task. Poster presented at the Annual Meeting of the Cognitive Neuroscience Society, San Francisco, CA. 24. MacDonald, A.W., III, Cohen, J.D., Stenger, V.A., & Carter, C.S. (June 2000). Functional double dissociation of dorsolateral prefrontal cortex and anterior cingulate cortex in cognitive control. Presented at the 6th Annual Meeting of the Society for Human Brain Mapping, San Antonio, TX. 25. MacDonald, A.W., III, Pogue-Geile, M.F., Thompson, J.L., Ross, L.L., Allen, T., Johnson, M.K., Lollo, N.D., Marquette, A.R., Yablonsky, E.J., Carter, C.S. (June 2000). Differential deficit in working memory, not attention, associated with liability to schizophrenia: a sibling study of the expectancy AX-CPT. Presented at the 30th Annual Meeting of the Behavior Genetics Association, Burlington, VT. 26. Carter, C.S., MacDonald, A.W., III, Ursu, S., & Stenger, V.A. (November 2000). Functional specialization within the frontal-parietal network supporting executive control. Presented at the 30th Annual Meeting of the Society for Neuroscience, New Orleans, LA. 27. MacDonald, A.W., III, Ross, L.L., Becker,, J., & Carter, C.S. (November 2000). Attentional control processes in DLPFC: domain specific or domain general? Presented at the 30th Annual Meeting of the Society for Neuroscience, New Orleans, LA. 28. Carter, C.S., Barch, D.M., MacDonald, A.W., III, Ursu, S. & Cohen, J.D. (April 2001). Prefrontal-related impairments in cognitive control are not specific to schizophrenia. Presented at the Eighth Biennial Meeting of the International Congress on Schizophrenia Research, Whistler, British Columbia, Canada. 29. MacDonald, A.W., III, Pogue-Geile, M.F., & Carter, C.S. (April 2001). Differential deficits in selective attention and working memory processes in the siblings of patients with schizophrenia. Poster presented at the Eighth Biennial Meeting of the International Congress on Schizophrenia Research, Whistler, British Columbia, Canada. 30. MacDonald, A.W., III, Pogue-Geile, M.F., Johnson, M.K. & Carter, C.S. (November 2001). Context processing in the unaffected siblings of patients with schizophrenia: Test of a differential deficit. Poster presentation at the 16th Annual Meetings of the Society for Research in Psychopathology, Madison, Wisconsin. Runner-up Smadar Levine Award. 31. Cho, R.Y, Cohen, J.D., van Veen, V., MacDonald, A.W., III, Kerns, J., Kriley, C. & Carter, C.S. (November 2002). Anterior cingulate correlates of trial-to-trial performance impairments in schizophrenia. Presentation at the 32nd Annual Meeting of the Society for Neuroscience, Orlando, FL. 32. MacDonald, A.W., III, Stenger, V.A., & Carter, C.S. (November 2002). Prefrontal cortical dysfunction and context processing deficits in unmedicated first-episode schizophrenia patients and 15 their unaffected relatives: an event-related fMRI study. Presentation at the 32nd Annual Meeting of the Society for Neuroscience, Orlando, FL. 33. Cho, R.Y., Cohen, J.D., van Veen, V., MacDonald, A.W., III, Kerns, J.G., Konecky, R., Belanger, C., & Carter, C.S. (April 2003). A multimodal examination of anterior cingulate cortex correlations from trial-to-trial performance impairments in schizophrenia. Poster presentation at the 9th Biennial International Congress of Schizophrenia Research, Colorado Springs, CO. 34. Holmes, A.J.*, MacDonald, A.W., III, Carter, C.S., Barch, D.M., Stenger, V.A., & Cohen, J.D. (April 2003). The specificity of context processing deficits associated with hypofrontality in schizophrenic patients: an event-related fMRI study. Poster presentation at the 9th Biennial International Congress of Schizophrenia Research, Colorado Springs, CO. 35. Becker, T.M.*, MacDonald, A.W., III, Pogue-Geile, M.F., & Carter, C.S. (April 2003). Demonstration of a differential deficit: empirical validation of psychometric principles using schizophrenia patients’ performance on working memory tasks. Poster presentation at the 9th Biennial International Congress of Schizophrenia Research, Colorado Springs, CO. 36. Kerns, J.G., MacDonald, A.W., III, Barch, D.M., Holmes, A.J., Cohen, J.D. & Carter, C.S. (April, 2003). Context processing deficits and decreased prefrontal cortex activity: specific associations with unmedicated, first-episode schizophrenia and with disorganization symptoms. Poster presentation at the 9th Biennial International Congress of Schizophrenia Research, Colorado Springs, CO. 37. Snitz, B.E., MacDonald, A.W., III, & Carter, C.S. (April 2003). Cognitive impairments in adult first-degree relatives of schizophrenia patients: a meta-analytic review. Poster presentation at the 9th Biennial International Congress of Schizophrenia Research, Colorado Springs, CO. 38. Carter, C.S., MacDonald, A.W., III, Holmes, A.J., & Stenger, V.A. (April 2003). Prospective longitudinal fMRI study of prefrontal cortex based context processing in never medicated firstepisode schizophrenia. Presentation at the 9th Biennial International Congress of Schizophrenia Research, Colorado Springs, CO. 39. MacDonald, A.W., III, Johnson, M.K., Becker, T.M. & Carter, C.S. (April 2003). Context processing deficits associated with hypofrontality in the healthy relatives of schizophrenia patients: an event-related fMRI study. Poster presentation at the 9th Biennial International Congress of Schizophrenia Research, Colorado Springs, CO. 40. MacDonald, A.W., III, Johnson, M.K., Rusticini, A. (October, 2004). Game theoretical indicators of paranoid personality. Poster presentation at the 19th Annual Meetings of the Society for Research in Psychopathology, St. Louis, Missouri. 41. Laes, J., Sponheim, S.R. & MacDonald, A.W., III (April 2005). Relationships between cognitive functions and current social functioning in schizophrenia and bipolar affective disorder. Poster presentation at the 10th Biennial International Congress of Schizophrenia Research, Savanna, Georgia. 42. Goghari, V.*, Rehm, K., Carter, C.S. & MacDonald, A.W., III (April 2005). MRI of prefrontal cortex in the healthy relatives of schizophrenia patients and controls. Poster presentation at the 10th Biennial International Congress of Schizophrenia Research, Savanna, Georgia. 43. Haut, K.* & MacDonald, A.W., III (April 2005). Persecutory delusions and the perception of trustworthy faces in schizophrenia. Poster presentation at the 10th Biennial International Congress of Schizophrenia Research, Savanna, Georgia. 16 44. Johnson, M.K.*, Rusticini, A., & MacDonald, A.W., III (April 2005). Effects of paranoidspectrum personality on social decision-making. Poster presentation at the 10th Biennial International Congress of Schizophrenia Research, Savanna, Georgia. 45. MacDonald, A.W., III, Carter, C.S., Flory, J.D., Ferrell, R.E., Manuck, S.B. (June 2005). Testing the advantage of specific deficits in experimental psychopathology using COMT Val158Met. Presentation at the Annual Meeting of the Behavioral Genetics Association. Hollywood, CA. 46. Goghari V.M.*, Rehm K., Carter C.S., MacDonald A.W., III. (June 2005). MRI of prefrontal and temporal cortex in the healthy relatives of schizophrenia patients. Poster Presentation at the 11th Annual Meeting of the Organization for Human Brain Mapping. Toronto, Ontario. 47. Sponheim, S.R., Bernat, E., Stanwyck, J.J., MacDonald, A.W., III, Chafee, M.V. (November 2005). Cue-dependent modulation of neural activity during object identification in schizophrenia patients. Poster Presentation at the Annual Meeting for the Society of Psychophysiological Research. Lisbon, Portugal. 48. Haut, K.H.*, Johnson, M.K., Hegeman, B.M., Goghari, V.M., MacDonald, A.W., III (November 2005). Cognitive Remediation and Changes in Prefrontal Cortical Function in Schizophrenia: A pilot fMRI report. Poster presentation at the 35th Annual Meeting of the Society for Neuroscience. Washington, D.C. 49. Goghari, V.M.*, Johnson, M.K., MacDonald, A.W., III (November 2005). Efficient acquisition of paired events in fMRI: comparison of techniques across a cognitive control paradigm. Poster presentation at the 35th Annual Meeting of the Society for Neuroscience. Washington, D.C. 50. Jain, S.*, Sponheim, S.R., Bernat, E.M., Chafee, M.V., MacDonald, A.W., III (April 2006). Neural correlates of cueing for objects in noise. Poster presentation at the Annual Meeting for the Cognitive Neuroscience Society. San Francisco, CA. 51. Goghari, V.M.* & MacDonald, A.W., III. (June 2006). Comparison of the neuroanatomical basis of cognitive control: Response selection versus response inhibition. Poster presentation at the 12 th annual meeting of the Organization for Human Brain Mapping. Firenze, Italy. 52. Haut, K.M.*, Johnson, M.K., Hegeman, B.M., Goghari, V.M., & MacDonald, A.W., III (June 2006). Cognitive remediation and changes in prefrontal cortical function in schizophrenia: a pilot fMRI report. Poster presentation at the 12th annual meeting of the Organization for Human Brain Mapping. Firenze, Italy. 53. MacDonald, A.W., III, Kang, S.S. (September 2006). What you don’t know about true-score variance can hurt you: simulation studies of the psychometric confound. Presentation at the 20th Annual Meeting for the Society for Research in Psychopathology, San Diego, CA. 54. Haut, K.M.* & MacDonald, A.W., III (October 2007). Cognitive training in schizophrenia: prefrontal cortical changes and behavioral correlates. Poster presentation at the 21st Annual Meeting of the Society for Research in Psychopathology, Iowa City, IA. Runner-up Smadar Levine Award. 55. Lim, K.O., Camchong, J., Bell, C.J., Fried, P., Mueller, B.A., MacDonald, A.W., III. (December 2007). Consistency of the resting state network within individual healthy participants across time. Poster presentation at the 46th Annual Meetings of the American College of Neuropsychopharmacology, Boca Raton, FL. 17 56. Camchong, J.*, Lim, K.O., Bell, C.J., Fried, P., Mueller, B.A., MacDonald, A.W., III. (May 2008). Functional connectivity abnormalities in schizophrenia during rest. Poster presentation at the 63rd Annual Meeting of the Society for Biological Psychiatry, Washington, D.C. 57. Beckes, L.*, Marsolek, C., MacDonald, A.W., III. (May 2008). Sex differences in the social malleability of facial attractiveness. Poster presentation at the 20th Annual Convention of the Association for Psychological Science, Chicago, IL. 58. MacDonald, A.W., III, Porter, J.N., Johnson, M.K., & Krueger, R.F. (November 2008). Imaging experience’s impact on the brain: an fMRI study of trust in identical twins discordant for persecutory ideation. Presentation at the Society for Neuroscience, Washington, D.C. 59. Hall, M.K., Nelson, J.W., Goghari, V.M., MacDonald, A.W., III, Stanwyck, J.J., Sponheim, S.R. (March 2009). Neural correlates of inhibitory motor control in schizophrenia patients and their biological relatives. Poster presentation at the International Congress of Research in Schizophrenia, San Diego, CA. 60. Nelson, J.W., Hall, M.K., Goghari, V.M., MacDonald, A.W., III, Stanwyck, J.J., Sponheim, S.R. (March 2009). Genetic aspects of motor inhibition in patients with schizophrenia and their nonpsychotic relatives. Poster presentation at the International Congress of Research in Schizophrenia, San Diego, CA. 61. Jones, J.H.*, Sponheim, S.R., Carter, C.S., MacDonald, A.W., III (March 2009). Properties of the Dot Pattern Expectancy (DPX) task for clinical use. Poster presentation at the International Congress of Research in Schizophrenia, San Diego, CA. 62. Kang, S.*, Bernat, E. M., Aviyente, S, Chafee, M.V., Im, C., MacDonald, A. W., III, Sponheim, S.R. (March 2009). Abnormal neural synchrony of cortical source signals during spatial working memory task in schizophrenia patients. Poster presentation at the International Congress of Research in Schizophrenia, San Diego, CA. 63. Haut, K.M. and MacDonald, A.W. Independent components analysis of working memory networks in schizophrenia. Poster presentation at the International Congress of Research in Schizophrenia, San Diego, CA. 64. Goghari, V.M.*, Sponheim, S.R., MacDonald, A.W., III (March 2009). Structure and function in schizophrenia patients, non-psychotic relatives, and community controls. Presentation at the International Congress of Research in Schizophrenia, San Diego, CA. 65. Camchong, J.*, Lim, K.O., Sponheim, S.R., MacDonald, A.W., III (March 2009). Diffusion tensor imaging studies of schizophrenia patients, first-degree relatives and healthy MZ twins. Poster presentation at the International Congress of Research in Schizophrenia, San Diego, CA. 66. Lim K.O., Camchong J., Bell C., Mueller B.A., MacDonald, A.W., III (March 2009). Functional connectivity abnormalities associated with abnormal behavior in schizophrenia. Presentation at the International Congress of Research in Schizophrenia, San Diego, CA. 67. MacDonald, A.W., III, Kang, S. (March 2009). Correcting for the psychometric confound on neuropsychological tasks: beyond true-score variance. Poster presentation at the International Congress of Research in Schizophrenia, San Diego, CA. 68. Blackman, R., MacDonald, A.W., III, Sponheim, S.E., Jain, S., Te, S., Chafee, M. (April 200). Effect of competing stimuli in a spatial categorization task as a means to study the cognitive deficits 18 observed in schizophrenia. Poster presentation the Association of American Physicians and the American Society for Clinical Investigation. PROFESSIONAL ACTIVITIES Journal Reviewing: 1. Consulting Editor: Journal of Abnormal Psychology (2005-present) 2. Ad Hoc Referee: Acta Psychiatrica Scandinavica (2006), American Journal of Psychiatric Genetics (2006), American Journal of Psychiatry (2006-2007), Archives of General Psychiatry (2003 – 2009), Biological Psychiatry (2004-2008), BioMed Central (BMC) Psychiatry (2004), Bipolar Disorder (2002), Brain and Behavioral Science (2002, 2006), Brain Research (2006), British Journal of Psychiatry (2009), Cognitive, Affective and Behavioral Neuroscience (2007, 2009), Cerebral Cortex (2003-2004), Emotion (2005-2006), Journal of Abnormal Psychology (1999 – 2004), Journal of Neuroscience (2006), Journal of Personality (2007), Neuroimage (2002, 2004), Neuropsychology (2005), Neuroscience (2005), Proceedings of the National Academy of Science, U.S.A. (2006, 2007, 2008), Psychological Medicine (2004, 2006), Psychiatry Research (2003), Schizophrenia Bulletin (2006, 2008, 2009), Schizophrenia Research (2004), Science (2006, 2009). Grant Reviewing: National Institute of Mental Health, Special Emphasis Panel ZMH1 ERB-S (01), Member, 2009 National Institute of Mental Health, Special Emphasis Panel ZMH1 ERB-Z (06), Member, 2008 Israeli Science Foundation, External Reviewer, 2007 National Institute of Mental Health, Special Emphasis Panel ZMH1 ERB-D, Member, 2007 National Institute of Mental Health, Special Emphasis Panel ZMH1 NRB-Q, Member, 2004 – 2005 National Medical Research Council, Singapore, External Reviewer, 2005 Wellcome Trust, United Kingdom, External Reviewer, 2004, 2006 University of Minnesota Medical Center, General Clinical Research Center, Reviewer, 2005 Western Psychiatric Institute & Clinic, Research Committee Reviewer, 2000-2002 Mentoring & Committee Service: Graduate Student Mentoring. 1. Vina Goghari, M.A., 2003-present. University of Minnesota Department of Psychology, Clinical Science and Psychopathology Research Program. a. College of Liberal Arts Graduate Research Partnership Program award “Prefrontal structure and function in the healthy relatives of schizophrenia patients and controls,” 2004. b. NSERC Masters Award, “Comparison of neuroanatomical basis of cognitive control and response inhibition”, 2004-2005. c. NSERC Doctoral Award, “Exploring the dual mechanisms of cognitive control”, 20052008. d. Department of Psychology David Campbell Research Fellowship, 2006. e. Master’s Thesis, “Efficient acquisition of paired events in fMRI: Comparison of techniques across a cognitive control paradigm.” March 2006. f. Graduate School Patrick & Kathy Lewis Thesis Research Grant, “Do you see what I see: The nature of emotion recognition deficits in schizophrenia.” November 2006. g. Vertically Integrated Research Team Experience (VIRTEx) Program fellowship, Summer 2007, “Prefrontal structure-function relationships in schizophrenia patients, their health relatives and controls.” h. Specials Paper, “The functional neuroanatomy of symptoms in schizophrenia.” August 2007. i. Clinical Internship: University of Illinois at Chicago, July 2008 – June 2009. 2. Kristen Haut, M.A., 2004-present. University of Minnesota Department of Psychology, Clinical Science and Psychopathology Research Program. a. College of Liberal Arts Graduate Research Partnership Program award “Functional neuroplasticity through cognitive rehabilitation in schizophrenia,” 2005. 19 3. 4. 5. 6. b. NIMH Clinical Science & Psychopathology Training Grant fellowship, 2005-2007. c. Wisconsin Symposium on Emotion Fellowship award, 2007. d. Master’s Thesis, “Prefrontal cortical changes following cognitive training in patients with schizophrenia.” June 2007. e. Eva O. Miller Fellowship award “Cognitive control over emotional reactivity in schizophrenia.” 2007-2008. f. Society for Research in Psychopathology 2007 Smadar Levine Award Runner Up, “Cognitive training in schizophrenia: prefrontal cortical changes and behavioral correlates.” g. Specials Paper, “Improving diagnosis in schizophrenia by evaluation of underlying neurocognitive deficits and functional connectivity.” February 2008. Seung Suk Kang, M.A., 2004-2008. University of Minnesota Department of Psychology, Biological Psychopathology Program, Co-Advisor with S.R. Sponheim. a. Specials Paper, “Functional disintegration syndrome of schizophrenia.” September 2007. b. College of Liberal Arts Graduate Research Partnership Program award, “MEG/fMRI Integration in the Study of PFC/Parietal Disconnectivity in Schizophrenia,” 2008. c. Dissertation, “Functional dysintegration syndrome of schizophrenia: a multimodal neuroimaging study.” November 2008. Rachel Force, M.A., 2004-present. University of Minnesota Department of Psychology, Biological Psychopathology Program, Co-Advisor with S.R. Sponheim. a. Master’s Thesis, “The specificity of auditory processing event-related potential anomalies in schizophrenia.” February 2007. b. Specials Paper, “A Model of the Neural Mechanisms Underlying Sensitivity Deficits on the DS-CPT in Schizophrenia.” February 2008. Melissa Johnson, 2005-present. University of Minnesota Department of Psychology, Clinical Science and Psychopathology Research Program. a. College of Liberal Arts Graduate Research Partnership Program award, “Neural underpinnings of suspicious personality characteristics,” 2006. b. Master’s Thesis, “Economic decision-making differentiates paranoid suspiciousness from rational mistrust and risk aversion.” May 2007. Jessica Hurdelbrink Jones, 2006-present, University of Minnesota Department of Psychology, Clinical Science and Psychopathology Research Program, a. College of Liberal Arts Graduate Research Partnership Program award “Context processing in psychometrically-identified schizotypes,” 2007. b. Master’s Thesis, “The Dot Pattern Expectancy Task: Reliability and Replication of Deficits in Schizophrenia,” 2008. Undergraduate Student Mentoring. 25 University of Minnesota Directed Research advisees (2003-present) 14 University of Pittsburgh Directed Research advisees (1998-2002) 1 Mentoring Connection (Mahtomedi High School) advisee (2005) 1. Theresa M. Becker, 2002, University of Pittsburgh Senior Honors Thesis, “Verbal & Spatial Working Memory Deficits in Schizophrenia Patients: General of Specific?” 2. Jessica L. Barker, 2003, University of Minnesota, Undergraduate Research Opportunities Program (UROP) Grant. 3. Kyle Ratner, 2003, Research Experience for Undergraduates (REU) Summer Program, “Cognitive Components of Economic Decision-Making.” 4. Marsha Sargeant, 2004, Research Experience for Undergraduates (REU) Summer Program, “Personality Correlates of Antisocial Behavior in Economic Decision-Making Games.” 5. Zack Adams, 2005, Research Experience for Undergraduates (REU) Summer Program, “A Multidimensional Exploration of Schizotypy and Normal Personality via Self-Report.” 6. James Porter, 2006, University of Minnesota Senior Honors Thesis, “Reliability of an Automated Method for Cortical Parcellation in the Analysis of Structural MRI.” Awarded “Poster of Note” (top 8 of 160) at 2006 University of Minnesota Undergraduate Research Session. 20 7. Margaret Flood, 2006, Research Experience for Undergraduates (REU) Summer Program, “Brain activity associated with switch-costs: an fMRI study.” 8. Megan Rozman, 2007, Undergraduate Research Opportunities Program (UROP) grant, “Dissociating Cognitive Processes in Psychometrically-Defined Schizotypy.” Awarded funding for National Conference on Undergraduate Research from the College of Liberal Arts. 9. Jennifer Ostergren, 2007, University of Minnesota Senior Honors Thesis, “Affective images in a flanker task: An investigation if cognitive control in emotion” Junita J. Mortensen Research Award from the Department of Psychology. 10. Margaret Wilke, 2007, University of Minnesota Senior Honors Thesis, “A Structured Interview Approach to the Subjective Experience of Suspiciousness” Junita J. Mortensen Research Award from the Department of Psychology. 11. Danielle Huber, 2007, Department of Psychology Senior Thesis. “Conceptualizing dimensions of trust.” 12. Maria Prom, 2007, Research Experience for Undergraduates (REU) Summer Program, “Test-retest reliability of functional MRI in schizophrenic patients within a working memory paradigm.” 13. Sylvia Sng, 2008, Undergraduate Research Opportunities Program (UROP) grant. 14. Adam Gierok, 2008, Department of Psychology Senior Honors Thesis. “COMT polymorphism and reasoning in schizophrenia and first-degree relatives of patients.” 15. Heather Watson, 2008, Department of Psychology Senior Thesis. “Behavioral differences among schizophrenia patients, first degree biological relatives, and controls in a Stop Signal Task.” 16. Annie Niesen, 2008, Department of Psychology Senior Thesis. “Test-retest reliability of cognitive control deficits in schizophrenia patients, relatives, and controls.” 17. Madelyn Steen, 2008, Department of Psychology Senior Honors Thesis. “The role of persecuted personality in suspicious and hostile decision-making.” 18. Elizabeth Davis, 2009. On-going. Other Mentoring. 1. Peter Milev, M.D., Ph.D., University of Minnesota School of Medicine Career Advancement Program for Clinical Research Scholars (CAPS), 2006-present. “Deficits in perceptual organization and thought disorder in schizophrenia: relationships with fMRI functional anatomy and with in vivo GABA and glutamate status measured with magnetic resonance spectroscopy.” Co-mentor. Thesis Committee Service. 1. Doctoral Theses a. Elizabeth Hurliman (Psychology, CSPR). “Feedback processing in the ventral prefrontal lobes.” November 2004. b. Adam Schmidt (Psychology, CSPR). “A behavioral profile of the adult rat following fetal/neonatal iron deficiency.” September 2005. c. Stephen Benning (Psychology, CSPR). September 2006. d. Molly Gill Willer (Psychology, CSPR). “Bulimia nervosa: towards a better understanding of diagnosis and treatment.” May 2007. e. Ela Bhatt (Rehabilitation Sciences). “Finger vs. elbow tracking: neural substrates of motor skill learning revealed using fMRI.” July 2007. f. Dongju Seo (Psychology, CSPR). “Cognitive control over positive and negative emotion.” July 2008. g. Susanne Vrshek-Schallhorn (Psychology, CSPR). “The effects of acute tyrosine phenylalanine depletion on emotion-based decision-making on the iowa gambling task in healthy adults.” August 2008. h. Seung Suk Kang (Psychology, Biological Psychopathology), “Functional dysintegration syndrome of schizophrenia: a multimodal neuroimaging study.” November 2008. i. Jaroslaw Grygolec (Economics), “Neuroeconomics of Social Decisions.” December 2008. 2. Comprehensive Specials Theses a. Stephen Benning (Psychology, CSPR). September 2004. b. Molly Gill Willer (Psychology, CSPR). “Prognostic Indicators for Outcome from Cognitive Behavioral Therapy for Bulimia Nervosa.” April 2005. 21 c. Michelle Stein (Graduate Program in Neuroscience). “Development of prefrontal abilities: performance of 8- and 11-year-old children on the Cambridge Neuropsychological Test Automated Battery.” May 2005. d. Ela Bhatt (Rahabilitation Sciences). Specialist Certificate Examining Committee. October 2005. e. Dongju Seo (Psychology, CSPR), “Neural Mechanism of Impulsive Aggression.” October 2006. f. Nicholas Davenport (Psychology, Biological Psychopathology), “Regional abnormalities of white matter volume and integrity in schizophrenia.” January 2007. g. Vina Goghari (Psychology, CSPR), ““The functional neuroanatomy of symptoms in schizophrenia.” August 2007. h. Seung Suk Kang (Psychology, Biological Psychopathology), “Functional disintegration syndrome in schizophrenia.” September 2007. i. Rachel Force (Psychology, Biological Psychopathology), “A Model of the Neural Mechanisms Underlying Sensitivity Deficits on the DS-CPT in Schizophrenia.” February 2008. j. Kristen Haut (Psychology, CSPR), “Improving diagnosis in schizophrenia by evaluation of underlying neurocognitive deficits and functional connectivity.” February 2008. 3. Master’s Theses a. Nicholas Davenport (Psychology, Biological Psychopathology). “Neural Anomalies During Visual Search in Schizophrenia Patients and Unaffected Siblings of Schizophrenia Patients.” December 2005. b. Vina Goghari (Psychology, CSPR) “Efficient acquisition of paired events in fMRI: Comparison of techniques across a cognitive control paradigm.” March 2006. c. Rachel Force (Psychology, Biological Psychopathology). “Specificity of auditory processing event-related potential anomalies in schizophrenia.” February 2007. d. Melissa Johnson (Psychology, CSPR) “Economic decision-making differentiates paranoid suspiciousness from rational mistrust and risk aversion.” May 2007. e. Kristen Haut (Psychology, CSPR) “Prefrontal cortical changes following cognitive training in patients with schizophrenia.” June 2007. f. Jessica Jones (Psychology, CSPR) “The Dot Pattern Expectancy Task: Reliability and Replication of Deficits in Schizophrenia,” October 2008. 4. Undergraduate Honors Theses a. JoAn Laes (Psychology). “Relationships between cognitive functions and current social functioning in schizophrenia and bipolar affective disorder,” May 2004. b. Nancy Meissner (Psychology). “Smell identification ability and cognitive associations in patients with deficit/nondeficit schizophrenia, bipolar affective disorder, and their relatives.” May 2005. c. Noah Venables (Psychology). “Negative emotionality, trait aggression, and brain potential responses in an affective 3-stimulus oddball paradigm.” December 2005. d. James Porter (Psychology). “Reliability of an automated method for cortical parcellation in the analysis of structural MRI.” May 2006. e. Jennifer Ostergren (Psychology). “Affective images in a flanker task: An investigation if cognitive control in emotion.” May 2007. f. Margaret Wilke (Psychology). “A structured interview approach to the subjective experience of suspiciousness.” May 2007. g. Adam Gierok (Psychology). “COMT polymorphism and reasoning in schizophrenia and first-degree relatives of patients.” May 2008. h. Heather Watson (Psychology). “Behavioral differences among schizophrenia patients, first degree biological relatives, and controls in a Stop Signal Task.” May 2008. i. Annie Niesen (Psychology). Test-retest reliability of cognitive control deficits in schizophrenia patients, relatives, and controls.” May 2008. Courses Taught: 22 1. Psychology 3633: Happiness: Integrating Research Across Psychological Sciences. Fall 2008. 2. Psychology 4960: Senior Seminar: Psychology of Love and Happiness. Fall 2006. 3. Psychology 5993 (formerly 4993/8993): Neuroimaging and Psychopathology (Research Seminar). Spring, Summer & Fall 2003; Spring, Summer & Fall 2004; Spring, Summer & Fall 2005; Spring & Fall 2006; Spring 2007; Spring & Fall 2008; Spring 2009. 4. Psychology 8814 : Analysis of Psychological Data (Psychology Graduate Core Curriculum). Fall 2003, Fall 2004, Fall 2005. 5. Psychology 8622: Treatment of Mental Disorders (Clinical Psychology and Psychopathology Research Program Required course). Fall 2003, Fall 2004, Fall 2005, Fall 2006, Spring 2009 6. Psychology 8960: Neuroimaging: Methods and Applications (Graduate Research Seminar). Spring 2004. 7. Guest Lectures: a. Psychology 5061: Behavioral Neuroscience. Instructor: Jonathan Gewirtz. Spring 2004, 2006. Topic: Neuroscience of Schizophrenia. b. Neuroscience 5661: Behavioral Neuroscience. Instructor: Karen Mesce. Spring 2004, 2005, 2007, 2009. Topic(s): Functional Neuroimaging, Neuroscience of Cognitive Control. c. Psychology 5604H: Honors Abnormal Psychology. Instructor: Gloria Leon. Spring 2006. Topic: Biological Basis of Schizophrenia. d. Cognitive Sciences 8040: Cognitive Neuroscience. Instructor: Matthew Chafee. Fall 2006, Spring 2009. Topic: Neuroscience of Schizophrenia. Academic Service: 1. College of Liberal Arts Assembly Representative, 2004-2006 2. College of Liberal Arts, Budget Advisory Committee Member, 2005-2007 3. College of Liberal Arts, Vertically-Integrated Research Team Experience (VIRTEx) Program, Developer & Director, 2007 - present 4. Psychology Department, Biological Psycholopathology Program, Director, 2008 - present 5. Psychology Department, Appointments Committee Member, 2006-2007 6. Psychology Department, Computer and Research Infrastructure Committee, 2004-2007 (Chair, Spring 2007). 7. Psychology Department, Awards and Admissions Committee, 2008 – present. 8. Psychology Department, MRI Users’ Group, Faculty Supervisor, 2004-2007, 2008-present. 9. Psychology Department, Neuroimaging Consortium, Director, 2006-present. Other Academic Service / Volunteer Activities: 1. Society for Research in Psychopathology, Website Development & Oversight Committee, 2004-2007 (Chair, 2004-2006). 2. Society for Research in Psychopathology, 2009 Annual Meeting, Local (Minneapolis) Host. 3. Society for Neuroscience, Community Presenter, Brain Awareness Week, 2004, 2005, 2009.