Quality Assurance Unit
Faculty of Pharmacy
Course Specifications
1- Basic Information:
Course code: 331
Year: third year
Course title:
PHARMACEUTICAL MICROBIOLOGY
AND BIOTECHNOLOGY
Theoretical: 36 hrs
Semester: second term
Practical: 20 hrs
2- Course Goals:
1.
2.
Prepare the student for being a pharmacist who can apply the provided knowledge about different
types of antimicrobial agents & their applications in their working area either as community or a
clinical pharmacist or in laboratory applications.
Giving rise to pharmacists capable of applying different sterilization protocols & sterility testing &
carry out microbiological QC testing in pharmaceutical companies.
3.
Provide the students with the basics enabling them to work in the field of biotechnology & bioengineering.
4.
Prepare creative, self learning, team working researcher.
3- Intended Learning Outcomes of Course (ILOs):
a. Knowledge and
understanding
After completing the course the student should be able to:
a.1.
Understand the modes of action and resistance and the clinical
uses of
a.2.
antibiotics and the non antibiotics antimicrobial agents.
Understand different techniques to evaluate antimicrobial
agents.
a.3.
sterility
a.4.
Understand the methods of sterilization and able to carry out
testing
Recognize how to handle the pharmaceutical preparations in
sterile area.
a.5.
Recognize the basic techniques in molecular biology and
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Quality Assurance Unit
Faculty of Pharmacy
molecular
genetics (DNA recombination, PCR, DNA sequencing,
tissue and cell culture)
a.6.
recognize
applications
of
biotechnology
in
food
&
pharmaceutical products.
b. Professional and
Practical Skills
After completing the course the student should be able to:
b.1. Carry out antibiotic susceptibility testing.
b.2. Evaluate antimicrobial agents (susceptibility of different types of
microbes &determination of MIC).
b.3. Design a microbiological assay method for antimicrobial agents.
b.4. Sterilize different pharmaceutical preparations with the suitable
sterilization method.
b.5. Avoid the different sources of contamination and work using aseptic
technique.
b.6. Carry out sterility testing for sterile pharmaceutical products.
c. Intellectual Skills After completing the course the student should be able to:
c.1. Predict different sources of microbial contamination of different
pharmaceutical preparations.
c.2. Follow up the experimental techniques and predict the results.
c.3. Observe different methods of DNA transfer & types of mutagens.
c.4. predict suitable techniques used in industrial microbiology for
production of biotechnological products.Design proposal for prevention
& control of parasitic diseases.
After completing the course the student should be able to:
d. General and
Transferable
d.1. Report writing through interpretation asked on the results of the
practical experiments.
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Faculty of Pharmacy
Skills
Quality Assurance Unit
d.2. Study independently to explore and browsing for a given search
points & discus the search results with the lecturer.
d.3. Solve problems in pharmaceutical industry especially in
microbiological area.
d.4. Improve student presentation skills through interactive presentations
in selected scientific topics.
4- Course Content:
1. Introduction & Classification types of Antibiotics .
2. Mode of action of Antibiotics.
3. Bacterial resistance to antibiotics & clinical use of a antibiotics.
4. Non antibiotic antimicrobial agents & it’s classification Mode of action , Resistance.
5. Applications of non antibiotic antimicrobial agents &Evaluation.
6. Microbial spoilage types, kinetics of microbial death.
7. Sterilization techniques Heat Sterilization Cold Sterilization.
8. Validation of Sterilization process , sterility test.
9. Principles of Biotechnology (methods of fermentation & production of antibiotics).
10. Application of Genetic engineering.
11. Microorganisms in food & pharmaceutical products.
12. Human growth hormone,insulin & improvement of plant through biotechnology.
5- Teaching and Learning Methods:
1. Direct lectures (a1,a2,a3,a4,a5,a6, c3,c4)
2. Laboratory practical (b1,b2,b3,b4 ,c1,c2)
3. Seminar for small groups to presents the activity research points(c3,c4,d1,d2,d3,d4).
6- Student Assessment:
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Faculty of Pharmacy
Methods of Assessment
Quality Assurance Unit
Weighting
Assessment Schedule
%
Practical exam
30
7th and 14th week
Written Exam
50
15th week
Oral Exam
20
15th week
7- List of Textbooks and References:
Pharmaceutical microbiology & immunology
1. Course Notes:
For third year students
2. Essential Books (Text
Books):
3. Recommended Books:
4. Periodicals, Web Sites:
Biology of microorganisms
Pharmaceutical microbiology
www.Pubmed.com
8- Required Facilities for Teaching & Learning:
1. Personal Computer (available for each staff member),
2. Power Point Displayer (Data-Show); easy available for the usual lectures and
Labs.
3. Lecture Hall
4. Computer Hall with enough devices and internet connection
5. Meeting rooms for office hours
9- Matrices of knowledge and skills:
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Faculty of Pharmacy
Topics
Quality Assurance Unit
Number of
weeks
Knowledge and
understanding
Professional
and Practical
Skills
Intellectual
Skills
General and
Transferable
Skills
The
or.
Pract.
1
1
a1,a2
b1,b2,b3
c1.c2
d1,d2,d3,d4
1
1
a1,a2
b1,b2,b3
c1.c2
d1,d2,d3,d4
1
a1,a2
b1,b2,b3
c1.c2
d1,d2,d3,d4
1
1
a1,a2
b1,b2,b3
c1.c2
d1,d2,d3,d4
1
1
a1,a2
b1,b2,b3
c1.c2
d1,d2,d3,d4
1
1
a3,a4
b4,b5,b6
c1.c2
d1,d2,d3,d4
c1.c2
d1,d2,d3,d4
c1.c2
d1,d2,d3,d4
c2,c3,c4
d1,d2,d3,d4
1. Introduction &
Classification types of
Antibiotics .
2. Mode of action of
Antibiotics.
3. Bacterial resistance to
antibiotics & clinical use
1
of antibiotics.
4. Non antibiotic
antimicrobial agents &
it’s classification Mode
of action , Resistance.
5. Applications of non
antibiotic antimicrobial
agents &Evaluation.
6. Microbial spoilage types,
kinetics of microbial
death.
7. Sterilization techniques
Heat Sterilization Cold
1
a3,a4
Sterilization.
8. Validation of
Sterilization process ,
1
1
a3,a4
1
2
a5,a6
b4,b5,b6
sterility test.
9. Principles of
Biotechnology (methods
of fermentation &
production of
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Faculty of Pharmacy
Quality Assurance Unit
antibiotics).
10. Application of Genetic
engineering.
1
1
a5,a6
c2,c3,c4
d1,d2,d3,d4
1
a5,a6
c2,c3,c4
d1,d2,d3,d4
1
a5,a6
c2,c3,c4
d1,d2,d3,d4
11. Microorganisms in food
& pharmaceutical
products.
12. Human growth
hormone,insulin &
improvement of plant
through biotechnology.
Teaching and Learning Methods
1. Direct lectures
Knowledge and
understanding
Professional and
Practical Skills
a1,a2,a3,a4,a5,a6,
Intellectual
Skills
General and
Transferable
Skills
c3,c4
b1,b2,b3,b4,b5,
b6
2. Laboratory practical
c1,c2
3. Seminar for small groups to
c3,c4
presents the activity
research points.
6
d1,d2,d3,d3
Faculty of Pharmacy
Student assessment methods
Quality Assurance Unit
Knowledge and
understanding
Professional and
Practical Skills
Intellectual
Skills
General and
Transferable
Skills
1. MCQ for assessment of
theoretical learning.
a1,a2,a3,a4,a5,a6
c1,c2,c3,c4
a1,a2,a3,a4,a5,a6
c1,c2,c3,c4
2. Oral examination for
assessment of
theoretical learning.
3. Practical examination
b1,b2,b3,b4,b5,
for assessment of the
b6
skills
Course Coordinator:
Signature:
Name:
Head of Department:
Signature:
Name:
Academic year: 2011/2012
Date:
7
d1,d2,d3,d4