INTERNATIONAL SYMPOSIUM ON SIGNAL TRANSDUCTION IN HEALTH AND
DISEASE (STADY V)
SUMMER NEUROPEPTIDE
CONFERENCE
Tel Aviv, Israel October 22-24, 2008
Venue: Lola & Dolfi Ebner Auditoriums, Tel-Aviv University
Tentative program
SYMPOSIUM I – ALZHEIMER’S DISEASE
AL-108: A case study for drug discovery and development toward cognitive enhancement
and neuroprotection
Gozes Illana (Israel)
Novel inhibitors of BACE-1: comparitive pharmamacology of 2-aminoheterocycles
Douglas Brenneman (USA)
A novel method to treat Alzheimer's disease: peripheral expression on the peptidase
neprilysin
Hersh Louis B (USA)
Cystatin C binds amyloid  and inhibits its oligomerization, fibril formation, and deposition in
Alzheimer's disease mouse models
Levy Efrat (USA)
Interrelations between dissociation of amyloid fibrils and ROS production
Lichtenberg Dov (Israel)
Hoyer Daniel (Switzerland)
SYMPOSIUM II – GnRH: FROM NEURON TO RECEPTOR
Roles of steroid hormone receptors in GnRH neuronal function
Catt Kevin (USA)
Kisspeptin signaling in the brain: Implications for puberty onset and female reproductive
health
Tena-Sempere Manuel (Spain)
Multiple targets of calcineurin in GnRH signalling to gonadotropin gene expression
Melamed Philippa (Singapore)
GnRH receptor signaling
Naor Zvi (Israel)
Journey to the hypothalamus, travels of the GnRH neuron
Mellon Pammella (USA)
Hormonal regulation of LH and GnRH mRNA expression in cultured rat
granulose cells
Koch Yitzhak (Israel)
SYMPOSIUM III- PROCESSING AND DEVELOPMENT
Notch Signaling: Theme and Variations
Kopan Raphael (USA)
Carboxypeptidase E in Neuroprotection and Cancer.
Peng Loh (USA)
Mechanisms of cell death in oligodendrocytes after proteasomal inhibition.
Richter-Landsberg Christiane
Chromatin remodeling in cortical development
Agoston Denes V. (USA)
Organizer-specific p38 MAPK-CREB pathway functions to pattern mesoderm in the frog
Xenopus laevis
Bengal Eyal (Israel)
SYMPOSIUM IV – UPDATE ON SIGNAL TRUNSDUCTION
Studying inositol lipid based signaling with novel molecular tools
Balla Tamas (USA)
Dynamics of Ras and Src membrane interactions and their relation to signaling
Henis Yoav (Israel)
The mechanism and function of MEK and ERK translocation into the nucleus
Seger Rony (Israel)
Signalling events in derepression of the LH receptor transcription
Dufau Maria (USA)
PKCα Degradation During Sperm Capacitation Leads to PKA-Mediated PI3K Activation
Haim (Israel) Breitbart
Brodie Chaya (Israel)
IGF-1 inhibits ER stress-induced apoptosis; mechanisms and implications
Leroith Derek (USA)
Signaling by Purinergic P2X Receptor Channels
Stojilkovic Stanko (USA)
GSK-3:the link between metabolism and neurodegenerative disorders
Eldar Hagit (Israel)
SYMPOSIUM V- NEUROPATHY, DIABETES AND METABOLISM
The role of CD59 in neuropathy
Chorev Michael
Physiopathological involvement of ghrelin in the control of growth and energy metabolism
Epelbaum Jacques (France)
Hypothalamic neuropeptides controlling energy balance
Nillni Eduardo A (USA)
Neuropeptide and Cytokines interact in upwinding chronic pain
Zimmermann Manfred (Germany)
PACAP Regulation of Gastrointestinal Secretion and Motility
Pisegna Joseph R. (USA)
Urocortins: emerging metabolic and energy homeostasis perspectives
Chen Alon (Israe)l
SYMPOSIUM VI – DEPRESSION
The Role of Melanin Concentrating Hormone Receptor, MCHR1, in mood disorders
Antal Ildiko (USA)
Behavioral Phenotypes of GALR1/GALR2 Double Knockout Mice: Relevance for Anxiety–
and Depression-Related Behaviors
Bailey Kathleen (USA)
The role of Ghrelin in feeding and memory performance
Daino Sabrina (USA)
PTSD/rat models
Gal Yadid (Israel)
PACAP
Pinhasov Albert (Israel)
Mesenchymal Stem Cells as a novel treatment for depressive disorders
Gadi Turgeman( Israel)
Galaninergic signaling in depression
Or IL-1 signaling in fever and inflammatory disease
Bartfai Tamas (USA)
SYMPOSIUM VII – BIOLOGICAL CLOCK
Developmental and Circadian Control of the Pineal Transcriptome
Klein David (USA)
Melatonin signaling in the human brain and its relevance to the treatment of insomnia and
circadian rhythm sleep disorders
Zisapel Nava (Israel)
Gothilf Yoav (Israel)
SYMPOSIUM VIII – SIGNAL TRUNSDUCTION IN PARKINSON DISEASE
Youdim Moussa B.H. (Israel)
Signal Transduction pathway involved in the mechanism of action of the anti-Parkinson's
drug rasagiline and its derivatives
Weinreb Orly (Israel)
Susceptibility Genes, Their Proteins And Treatment Targets In Sporadic Parkinson's
Disease
Mandel Silvia (Israel)
Chemokines are neuromodulators of dopaminergic transmission
Rostene William (France)
SYMPOSIUM IX – CANCER
Beyond Oncogenes and Tumor Suppressors: Caveolin-1 as a Model
Liscovitch Moti (Germany)
The many functions of 60 KDa heat shock proteins (HSP60).
HSP60 proteins are linked to cancer and diabetes
Abdussalam Azem (Israel)
SYMPOSIUM X – THE MANY FACES OF NEUROPEPTIDES
Novel neuropeptide and cytokine responsive genes in the nervous system: discovery
through microarray analyses in cells and in vivo
Eiden Lee
Signaling events regulating corticotrophin releasing hormone expression
Greti Aguilera (USA
Emerging role for neuropeptides in host-virus interaction
Weihe Eberhard (Germany
Insect neuropeptides: Challenges and achievements.
Vinnie Altstein
Localisation and function of the novel neuropeptide alarin in the central nervous system
Barbara Kofler (Austria)
Low Molecular Weight Ligands for the Human Thyrotropin Receptor with Therapeutic
Potential for Hyperthyroidism and Thyroid Cancer
Gershengorn Marvin (USA
SYMPOSIUM XI – OOCYTES
Steroids and resumption of oocyte meiosis: Are mammals so much distinct?
Tsafriri Alex (Israel
AN LH-INDUCED ELEVATION IN INTRAOOCYTE cAMP TRIGGERS PDE3A
ACTIVATION FACILITATING MEIOSIS REINITIATION
Dekel Nava (Israel)
ADDITIONAL LECTURES (Titlels TBD)
Rotshenker Shlomo (Israel)
Schlessinger Joseph (USA)