FINAL SCIENTIFIC PROGRAMME Tuesday, 22 November 2011 09:00 Registration and Coffee ___________________________________________________________________ 10:00 - 10:30 Opening Session Senate Hall ___________________________________________________________________ Chairperson: Adee Matan, Israel WELCOME Rivka Carmi, President, Ben-Gurion University of the Negev Matthew Gould, British Ambassador to Israel ___________________________________________________________________ 10:30 - 13:00 Plenary Session Senate Hall ___________________________________________________________________ HIGHLIGHTS OF REGENERATIVE MEDICINE Chairpersons: Lord Naren Patel, UK Benjamin Geiger, Israel 10:30 HUMAN EMBRYONIC STEM CELLS – FROM BENCH TO BEDSIDE Benjamin E. Reubinoff, Hadassah University Medical Center, Jerusalem, Israel 11:00 V BIO-INSPIRED MATERIALS FOR REGENERATIVE MEDICINE Smadar Cohen, Ben-Gurion University of the Negev, Beer Sheva, Israel 11:30 Coffee Break 12:00 TISSUE ENGINEERING: AN ENABLING TECHNOLOGY Dame Julia Polak, Imperial College London, UK Tuesday, 22 November 2011 (cont.) 12:30 EPICARDIUM-DERIVED CARDIAC REPAIR Paul R. Riley, University College London, UK 13:00 Lunch ___________________________________________________________________ 14:00 - 18:00 Session 2A Barkan Hall ___________________________________________________________________ TRANSLATIONAL CELL THERAPY IMMUNOLOGY & MANUFACTURE Chairpersons: Tamir Ben-Hur, Israel Julie Daniels, UK 14:00 STEM CELL THERAPIES FOR SKELETAL DISORDERS Dan Gazit, The Hebrew University of Jerusalem, Israel 14:30 HUMAN PLURIPOTENT STEM CELLS: IMPLICATIONS FOR BASIC AND TRANSLATIONAL CARDIAC RESEARCH Lior Gepstein, Technion, Israel Institute of Technology, Haifa, Israel 15:00 STEM CELL THERAPY IN ALS Daniel Offen, Tel Aviv University, Tel Aviv, Israel 15:30 STEM CELL THERAPY FOR BLINDING CORNEAL DISEASE Julie Daniels, UCL Institute of Ophthalmology, London, UK 16:00 Coffee Break 16:30 THE CHONDROCYTE: A FLEXIBLE TOOL FOR RECONSTRUCTION James B. Richardson, RJAH, NHS Trust, UK 17:00 TISSUE ENGINEERING CHALLENGES IN ORTHOPAEDIC SURGERY Andrew McCaskie, Newcastle University, UK 17:30 Poster presentations 18:00 Buses return to hotel 19:00 Depart for Bedouin Style Dinner - one bus from the university and two buses from the hotel Tuesday, 22 November 2011 (cont.) ___________________________________________________________________ 14:00 - 18:00 Session 2B Oren Hall ___________________________________________________________________ STEM CELL / TRANSPLANTATION IMMUNOLOGY & MANUFACTURE Chairpersons: Paul Fairchild, UK Yair Reisner, Israel 14:00 MECHANISMS OF PANCREATIC BETA CELL REGENERATION Yuval Dor, The Hebrew University of Jerusalem, Israel 14:30 ALPHA-1 ANTITRYPSIN PROTECTS CELL TRANSPLANTS, FACILITATES ANGIOGENESIS AND ENHANCES GRAFT-SPECIFIC IMMUNE TOLERANCE IN VIVO Eli Lewis, Ben-Gurion University of the Negev, Beer Sheva, Israel 15:00 PIG EMBRYONIC PANCREATIC TISSUE FOR CORRECTION OF DIABETES Yair Reisner, Weizmann Institute of Science, Rehovot, Israel 15:30 DENDRITIC CELLS AND PLURIPOTENCY: UNEXPECTED ALLIES IN THE PURSUIT OF IMMUNOTHERAPY Paul Fairchild, University of Oxford, Oxford, UK 16:00 Coffee Break 16:30 MANUFACTURE AND SUPPLY OF A CELLULARISED BIOCOMPATIBLE POLYMER SCAFFOLD AS AN ADVANCED THERAPY MEDICINAL PRODUCT FOR TRACHAEAL REPLACEMENT Mark Lowdell, University College London, UK 17:00 CELL THERAPY TO PROMOTE TRANSPLANTATION TOLERANCE: A WINNING STRATEGY? Giovana Lombardi, King’s College London, London, UK 17:30 Poster presentations 18:00 Buses return to hotel 19:00 Depart for Bedouin Style Dinner - one bus from the university and two buses from the hotel Wednesday, 23 November 2011 ___________________________________________________________________ 08:15 - 09:00 Optional Session A Barkan Hall ___________________________________________________________________ QUESTIONS AND ANSWERS Questions and answers related to the BIRAX Regenerative Medicine Initiative Call for Proposals, British Council, Israel ___________________________________________________________________ 08:15 - 09:00 Optional Session B Oren Hall ___________________________________________________________________ PARTY PITCH YOUR POST-DOC Science Communication / Networking for early career researchers Facilitated by Aarathi Prasad, freelance science journalist, author and broadcaster, Natural Resources / Science Communication Advisor, British Council, UK ___________________________________________________________________ 09:00 - 12:30 Session 3A Barkan Hall ___________________________________________________________________ STEM CELL DERIVATION, GENOMICS, GENOMICS REPROGRAMMING & EPIGENETICS Chairpersons: Nissim Benvenisty, Israel Paul De Sousa, UK 09:00 THE ROLE OF PLURIPOTENT STEM CELLS IN MODELING HUMAN DISORDERS Nissim Benvenisty, The Hebrew University of Jerusalem, Israel 09:30 UNDERSTANDING THE IDENTITY AND STABILITY OF PLURIPOTENT CELL STATES Jacob Hanna, Weizmann Institute of Science, Rehovot, Israel 10:00 THE ROLE MIRNAA PLAY AS DEVELOPMENTAL SWITCHES Eran Hornstein, Weizmann Institute of Science, Rehovot, Israel 10:30 DEVELOPING SCALABLE AUTOMATION OF HUMAN PLURIPOTENT STEM CELL (HPSC) EXPANSION AND DIFFERENTIATION FOR MULTIPLE SCREENING APPLICATIONS Lorraine Young, University of Nottingham, UK 11:00 Coffee Break 11:30 PLURIOPTENT STEM CELL TRANSLATION: BASIC AND APPLIED SCIENCE SUPPORTING HUMAN EMBRYONIC STEM CELLS IN REGENERATIVE MEDICINE Paul De Sousa, University of Edinburgh, UK 12:00 MESODERM DIFFERENTIATION IN PLURIPOTENT MAMMALIAN STEM CELLS Roger Pedersen, University of Cambridge, UK 12:30 Lunch Wednesday, 23 November 2011 (cont.) ___________________________________________________________________ 09:00 - 12:30 Session 3B Oren Hall ___________________________________________________________________ BIOMATERIALS, TISSUE ENGINEERING Chairpersons: Hanna Rapaport, Israel Kevin Shakesheff, UK 09:00 NANOTECHNOLOGICAL STRATEGIES FOR MENDING BROKEN HEARTS Tal Dvir, Tel Aviv University, Israel 09:30 NATURAL EXTRACELLULAR MATRIX PLATFORMS TOWARDS ENGINEERING OF THICK CARDIAC CONSTRUCTS Marcelle Machluf, Technion, Israel Institute of Technology, Haifa, Israel 10:00 SELF ASSEMBLED ACIDIC PEPTIDES; FROM DESIGN TO BIOMATERIALS FOR BONE TISSUE REGENERATION Hanna Rapaport, Ben-Gurion University of the Negev, Beer Sheva, Israel 10:30 NEW MATERIALS-BASED STRATEGIES FOR REGENERATIVE MEDICINE Molly Stevens, Imperial College London, UK 11:00 Coffee Break 11:30 CONTROLLING CELL BEHAVIOUR USING 3D ARCHITECTURES Kevin Shakesheff, University of Nottingham, UK 12:00 CONTROLLING CELLS FOR USE IN CLINICAL THERAPIES USING MAGNETIC NANOPARTICLES Alicia El Haj, Keele University, UK 12:30 Lunch Wednesday, 23 November 2011 (cont.) ___________________________________________________________________ 13:30 - 16:30 Session 4A Barkan Hall ___________________________________________________________________ STEM CELL BIOLOGY: LESSONS FROM DEVELOPMENT Chairpersons: Sue Kimber, UK Dov Zipori, Israel 13:30 A REGULATORY NETWORK OF TISSUE-SPECIFIC MODIFIERS UNDERLIES THE ETIOLOGY OF DIGEORGE DELETION SYNDROME Eldad Tzahor, Weizmann Institute of Science, Rehovot, Israel 14:00 TRANSLATING HUMAN KIDNEY DEVELOPMENT TO CELL THERAPY OF RENAL INJURY AND TARGETED THERAPY OF RENAL CANCER Benjamin Dekel, Sheba Medical Center, Tel Hashomer, Israel 14:30 MESENCHYMAL STROMAL CELLS AS A PARADIGM OF THE STEM STATE: PLASTIC NATURE ENTAILING HETEROGENEITY AND CAPACITY TO DEDIFFERENTIATE Dov Zipori, Weizmann Institute of Science, Rehovot, Israel 15:00 REGULATION OF NEURAL STEM CELLS BY INTEGRINS AND EXTRACELLULAR MATRIX Charles ffrench-Constant, University of Edinburgh, UK 15:30 TWINNING: THE ULTIMATE REGENERATION Claudio D. Stern, University College London, UK 16:00 GENERATION OF CHONDROGENIC CELLS FROM HUMAN PLURIPOTENT CELLS Sue Kimber, University of Manchester, UK 16:30 Coffee Break Wednesday, 23 November 2011 (cont.) ___________________________________________________________________ 13:30 - 16:30 Session 4B Oren Hall ___________________________________________________________________ GENE THERAPY AND GENE-MODIFIED CELLS Chairpersons: Andrew Baker, UK Tamir Ben-Hur, Israel 13:30 DEVELOPMENT OF BETA-CELL REPLACEMENT THERAPY FOR DIABETES Shimon Efrat, Tel Aviv University, Israel 14:00 USE OF AUTOLOGOUS VENOUS ENDOTHEIAL AND SMOOTH MUSCLE CELLS MODIFIED BY GENE TRANSFER FOR INDUCTION OF ARTERIOGENESIS Moshe Flugelman, Technion, Israel Institute of Technology, Haifa, Israel 14:30 DIRECT REPROGRAMMING OF HUMAN ADULT CELLS INTO INSULIN PRODUCING CELLS; CELL REPLACEMENT THERAPY FOR DIABETIC PATIENTS Sarah Ferber, Sheba Medical Center, Tel Hashomer, Israel 15:00 GENE THERAPY FOR IMMUNODEFICIENCY Adrian Thrasher, University College London, UK 15:30 MODIFYING VEIN GRAFTS BY GENE THERAPY Andrew Baker, University of Glasgow, UK 16:00 CELL THERAPY FOR MULTIPLE SCLEROSIS Tamir Ben-Hur, Hadassah Medical Center, Jerusalem, Israel 16:30 Coffee Break ___________________________________________________________________________________ 17:00 - 19:00 Closing Plenary Discussion Senate Hall ___________________________________________________________________ POSTER AWARDS Prizes will be awarded for the 3 best posters by Simon Kay, Director, British Council Israel and Adee Matan, Science and Innovation Attache, British Embassy REGENERATIVE MEDICINE: THE ROAD AHEAD Moderators: Chris Mason, UK Smadar Cohen, Israel Panelists: Martin Birchall, UK Anthony Hollander, UK Joseph Itskovitz-Eldor, Israel Michel Revel, Israel Yosef Shiloh, Israel Glyn Stacey, UK CLOSING REMARKS Simon Kay, Director, British Council Israel 19:30 Return transfer to the hotel