Cell Biology Course (Cell and Dev. Biology 530)
Michael Hortsch/Fall 2003
Cell Junctions and Cell and Substrate Adhesion Molecules
***References in bold indicate assigned reading ***
Cell Junctions, SAMs and CAMs general:
Alberts et al., Molecular Biology of the Cell (4th ed.) Garland Schience, Pages 1065-1080
Lodish et al., Molecular Cell Biology (4th ed.) W.H. Freeman and Co. Pages 968-971.
Integrins:
Alberts et al., Molecular Biology of the Cell (4th ed.) Garland Schience, Pages 1113-1118 or
Lodish et al. Molecular Cell Biology (4th ed.) W.H. Freeman and Co. Pages 976-979.
Burridge, K., and Chrzanowska-Wodnicka, M. (1996). Focal adhesion, contractility, and signaling.
Annu. Rev. Cell Biol., 12, 463-518.
De Arcangelis, A., & Georges-Labouesse, E. (2000). Integrin and ECM functions: roles in vertebrate
development. Trends in Genetics 16, 389-395.
Humphries, M.J. (2000). Integrin cell adhesion receptors and the concept of agonism. Trends Pharm.
Sci. 21, 29-32.
Clegg, D.O., et al. (2003). Integrins in the Development, Function and Dysfunction of the Nervous
System. Front. Biosci. 8: 723-750.
Immunoglobulin domain CAMs:
Alberts et al., Molecular Biology of the Cell (4th ed.) Garland Schience, Pages 1086-1088 or
Lodish et al. Molecular Cell Biology (4th ed.) W.H. Freeman and Co. Pages 971-972.
Panicker, A.K. et al. (2003). Cellular Signalling Mechanisms of Neural Cell Adhesion Molecules. Front.
Biosci. 8: 900-911.
Walsh, F.S., and Doherty, P. (1997). Neural cell adhesion molecules of the immunoglobulin
superfamily: Role in axon growth and guidance. Annu. Rev. Cell Biol., 13, 425-56.
Selectins:
Alberts et al., Molecular Biology of the Cell (4th ed.) Garland Schience, Pages 1085-1086 or
Lodish et al. Molecular Cell Biology (4th ed.) W.H. Freeman and Co. Pages 972-973.
Rosen, S.D. and C.R. Bertozzi (1995). The Selectins and Their Ligands. Curr. Opin. Cell Biol., 7, 663673.
Tight Junctions and their Components:
Alberts et al., Molecular Biology of the Cell (4th ed.) Garland Schience, Pages 1066-1070 or
Lodish et al. Molecular Cell Biology (4th ed.) W.H. Freeman and Co. Pages 602-608.
Stevenson, B.R., and Keon, B.H. (1998). The Tight Junctions: Morphology to Molecules. Annu. Rev.
Cell Dev. Biol., 14, 89-109.
Tsukita, S., & Furuse, M. (1999). Occludin and claudin in tight-junction strands: leading or supporting
players? Trends in Cell Biol., 9, 268-273.
Gap Junction Proteins
Alberts et al., Molecular Biology of the Cell (4th ed.) Garland Schience, Pages 1074-1080 or
Lodish et al. Molecular Cell Biology (4th ed.) W.H. Freeman and Co. Pages 974-976.
Kumar, M.N., and Gilula, N.B. (1996). The Gap Junction Communication Channel. Cell, 84, 381-388.
Simon, A.M., Goodenough, D.S. (1998). Diverse functions of vertebrate gap junctions. Trends Cell
Biol. 8, 477-483.