REVISION PROJECT C436- IL ISRAEL NEW PROPOSAL REQUEST FOR REVISION OF THE IPC (CL) Class(es) or subclass(es): C12N , C12P 1. Demarcation of the area to be revised: C12N 5/00, C12N 15/00, C12P 21/00 2. Reasons for the request: (a) (b) (c) (d) (e) Creation of IPC places covering new technologies for which no distinct place in the IPC exists Clarification of wordings in order to improve consistency in classifying or to avoid overlap with other places of the IPC Subdivision of IPC groups having a very large file size and a very high rate of growth of the national patent documentation Modifications required by revision changes to the advanced level Other reasons [X ] [ ] [ ] [ ] [ ] Explanation of above: 3. For requests under 2(c), numerical data of the relevant national documentation: (a) (b) (c) (d) 4. File size: [200 ] Rate of growth (applications filed in) Average size of new subgroups: Proposal tested? YES [ X ] Detailed proposal: 2003: [ ] [ ] NO [ ] 2004: [ ] Submitted herewith We are prepared to elaborate it We are not in a position to elaborate it 5. General outline, possible solutions, options, etc.: IL read the comments from : GB, US, JP, DE, EPO And here are the changes: - classification C12N5/027 changed to: Interaction between peptides, cells and molecules controlling the interaction of cells. - IL also add another classification that belongs to this classification. C12N5/035- Molecule inhibitors and method of inhibiting cell adhesion. IL add examples to show these changes. [X] [ ] [ ] - As proposed by the EPO . Adhesion culture is added. -Processes for producing polypeptides and proteins using recombinant DNA technology (e.g., vectors ,recombinant cells, etc.)- The right place for this classification is C12P21/ because this classification relates to preparation of peptides or proteins. IL disagree with GB since C12N15/63 relates to introduction of foreign genetic material using vector. It does not relate to the production of proteins and peptides. - The differences between Chimeric and fusion proteins are: Fusion protein- protein formed by expression of a hybrid gene made by combining two gene sequences. Fusion relates to combining peptides or proteins from the same species or from different species. - Chimera-organism composed of two genetically distinct types of cells. That means that chimeric relates only to different species. Chimeric proteins will not relate to fusion of proteins from the same species. this is the reason there should be a clear distinction between fusion and chimeric. To show the differences between them IL add examples. Proposing Office: Israel Patent Office Date: Signature: DETAILED PROPOSAL SUBCLASS: C12N N 5/03 . Interaction between peptides, cells and molecules controlling the interaction of cells N 5/033 . Adhesion culture N 5/035 . Molecule inhibitors and method of inhibiting cell adhesion N 5/28 . . Chimeric cells N 15/625 . . . DNA sequences coding for chimeric proteins SUBCLASS: C12P N 21/10 . . Processes for producing polypeptides and proteins using recombinant DNA technology (e.g., vectors ,recombinant cells, etc.) EXAMPLES FOR: . Interaction between peptides, cells and molecules controlling the interaction of cells 1. Oligonucleotide modulation of cell adhesion. See EP-544716. 2. Cell surface molecule mediating cell adhesion and signal transmission. See EP-1502920. 3. Novel agent for controlling cell activity. See WO9421300. 4. Functional derivatives of ICAM-1 which are substantially capable of binding to LFA-1 but are substantially incapable of binding to MAC-1. See US5288854. 5. Methods and pharmaceutical compositions for GnRH-1 and GnRH-II modulation of Tcell activity, adhesion, migration and extravasation. See EP- 1465656. 6. Soluble truncated form of ICAM-1. See US 6143298. 7. Soluble fragments of human intercellular adhesion molecule -1. See US-5831036. 8. Soluble truncated forms of Icam-1. See US-6143298 EXAMPLES FOR: Molecule inhibitors and method of inhibiting cell adhesion 1. Preparation of cellular adhesion inhibitors, antiadhesins so obtained and foods containing them. See EP-201390. 2. Peptide inhibitors of cell adhesion. See IL-110221. 3. Method for reducing unwanted cellular adhesions. See WO- 9610912. 4. Cell adhesion inhibitors. See WO 9622966 (IL-116846). EXAMPLES FOR: Chimeric cells and DNA sequences coding for chimeric proteins Here are examples that will show the differences between chimeric and fusion 1. Chimeric toxins for targeted therapy. See WO-9746259(IL-118570). 2. Immunoglobulin chimeric monomer – dimmer hybrids. See US-20050032174 3. Mixed specificity fusion protein. See EP-568645. EXAMPLES FOR: Processes for producing polypeptides and proteins using recombinant DNA technology (e.g., vectors ,recombinant cells, etc.) 1. Transformed cell, process for producing protein using the cell ' protein production kit….. See EP- 1672066. 2. Cytokine receptor ZALPHA 11. See EP- 1115862. 3. Novel protein and process for producing the same. See WO- 0014226. 4. Expression cloning process for gene coding for a zinc – binding protein. See US- 6846624. 5. Process for preparing a desired protein.See US- 5618697. Orit Regev ISRAEL