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"Antigenic variants of Venezuelan equine encephalitis virus: their geographic distribution and epidemiologic significance." Am J Epidemiol 89(3): 286-307. Young, N. A. and K. M. Johnson (1969). "Viruses of the Venezuelan equine encephalomyelitis complex. Infection and cross-challenge of rodents with VEE, Mucambo, and Pixuna viruses." Am J Trop Med Hyg 18(2): 280-9. Young, N. A., K. M. Johnson, et al. (1969). "Viruses of the Venezuelan equine encephalomyelitis complex. Experimental infection of Panamanian rodents." Am J Trop Med Hyg 18(2): 290-6. Yuill, T. M. (1986). "The Ecology of Tropical Arthropod-Borne Viruses." Ann Rev Ecol Syst 17: 189—219. 144 Zhang, M., K. Wang, et al. (2006). "Recovery of a rodent community in an agroecosystem after flooding." J Zoology 272(2): 138—147. 145 VITA Eleanor Rose Deardorff was born in Santa Fe, New Mexico on January 20th, 1978 to David Deardorff and Anna Richards. She graduated from Santa Fe High School in 1996. While completing her graduate work at the University of Texas Medical Branch Eleanor served as a graduate student senator in the student government association. She also received the James W. McLaughlin Predoctoral Fellowship, the National Institute of Health T32 Training Grant in Biodefense and the Center for Disease Control’s Fellowship Training Grant in Vector Borne Infectious Diseases. Eleanor won 3rd place in the 2008 Hector P. Garcia cultural competence essay contest for her essay “Home away from home” on her experiences as an American student doing field work in rural areas of coastal Chiapas, Mexico. Education B.A. May 2001, Reed College, Portland, Oregon. Publications Greene, I. P., Wang, E., Deardorff, E. R., Milleron, R., Domingo, E., and Weaver, S. C. Effect of alternating passage on adaptation of Sindbis virus to vertebrate and invertebrate cells. 2005. J. Virol., Vol 79, No. 22, p.14253—14260. Deardorff, E.R., Estrada-Franco, J.G., Brault, A.C., Navarro-Lopez, CampomanesCortes, A., Paz-Ramirez, P., Solis-Hernandez M., Ramey, W., R., Davis, C.T., Beasley, D.W.C., Tesh, R.B., Barrett, A.D.T., and Weaver, S.C. Introductions of West Nile Virus to Mexico. 2006. Emerging Infectious Disease, Vol.12, No.2, p.314—318 Forrester, N. L., Kenney, J. L., Deardorff, E. R., Wang, E. & Weaver, S.C. Western equine encephalitis submergence: lack of evidence for a decline in virus virulence. 2008. Virology, Vol. 380, No. 2, p. 170-172. Deardorff, E.R., Forrester, N.L., Travasos da Rosa, A., Estrada-Franco, J.G., NavarroLopez, R., Tesh, R.B., Weaver, S.C. Experimental infections of potential Mexican reservoir hosts with Venezuelan equine encephalitis virus. 2009. Emerging Infectious Disease, Vol. 15, No. 4, p.519—525. Deardorff, E.R., Forrester, N.L., Travasos da Rosa, A., Estrada-Franco, J.G., NavarroLopez, R., Tesh, R.B., Weaver, S.C. Experimental Infections of Oryzomys couesi With Sympatric Arboviruses from Mexico. 2009, American Journal of Tropical Medicine and Hygiene, in Press. Summary of Dissertation I investigated the emergence of Venezuelan equine encephalitis virus in Chiapas Mexico. This virus was not previously associated with equine disease in Mexico. The evolution of the equine virulent phenotype was thought to have resulted in a mosquito vector switch from Culex (Melanoconion) taeniopus to Aedes (Ochlerotatus) taeniorhynchus as a result 146 of land-use changes. I spent a year capturing wild rodents and mosquitoes and found little evidence of virus circulation. I then imported rodents from five species into the lab for experimental evaluation as virus amplifying hosts and found that VEEV may use a variety of rodents as amplifying hosts in this area. Lastly I encountered unexpectedly high numbers of Culex (Mel.) taeniopus and decided to colonize this mosquito in order to experimentally evaluate it’s ability to transmit equine virulent VEEV. I found that equine virulent virus infects and is transmitted by this mosquito with high efficiency and is likely maintained in transmission foci by Culex (Mel) taeniopus during inter-epizootic periods. 147