Post-doctoral position in Computational Systems Biology for the ANR Project “Skin TSLP”, at Institut Curie, Paris, France The position is open in the frame of the ANR project « Role of the keratinocyte-derived cytokine Thymic Stromal Lymphopoietin (TSLP) in human skin inflammation “, coordinated by Dr Vassili Soumelis at Institut Curie, Department of Immunology. The project: This project aims at studying the role of the cytokine TSLP in skin inflammation in a global way: molecular regulation in specific systems and relative function within a complex inflammatory network reflecting the pathophysiology of atopic dermatitis and other skin inflammatory diseases. To address these challenging questions, we will use a combination of in vitro cellular and molecular immunology with systems biology approaches to dissect transcriptional profiles induced by complex stimuli. The project will be developed in an interdisciplinary way in collaboration with the Department of Bioinformatics and Computational Systems Biology of Cancer (Dr E. Barillot). The post-doctoral fellow will develop and carry out computational systems biology approaches to identify the factors and molecular pathways leading to TSLP production by skin keratinocytes, reconstitute TSLP-driven networks relevant to atopic dermatitis, and characterize the function and dominance of TSLP within a complex inflammatory environment. Requirements for the candidates: We expect a candidate with a PhD in cell biology, immunology, computational biology, biostatistics or bioinformatics. The successful candidate will have a strong experience in computational data analysis and modeling in biology. Ideally, the candidate should be able to demonstrate some knowledge of the biological mechanisms involved in skin inflammation, and should have experience of interdisciplinary projects mixing, clinics and mathematics. Some programming skills will be useful (R, Perl). Good knowledge of English both spoken and written is required. The position is open immediately and funded for 2 years with possible extension. Please send CV, letter of motivation and references to email@example.com For further information please contact Vassili.Soumelis@curie.net Emmanuel.Barillot@curie.fr and Mission location: Institut Curie, Paris, « Bioinformatics and Computational Systems Biology of Cancer » Laboratory and Department of Immunology Institut Curie (http://www.curie.fr) is one of the biggest European institutions for cancer research with a strong interdisciplinary tradition. It also comprises a hospital specialized in cancer treatment, and therefore dispose of a continuum of expertise from fundamental research to patient care. It is located in the center of Paris in a both cultural and scientific rich environment. The Bioinformatics Laboratory of Institut Curie was created in 2003. In January 2008, it has become an INSERM mixed unit “Bioinformatics and Computational Systems Biology of Cancer” (Research unit 900 INSERM – Mines ParisTech – Institut Curie) involving about 50 researchers and students, and headed by Dr Emmanuel Barillot. It is a very active and growing interdisciplinary team of biologists, mathematicians, statisticians, physicists and computer scientists. The Immunology Department is headed by Sebastian Amigorena and was initially centered on the cell biology of dendritic cells (DC). It now gathers 8 groups with complimentary expertise, ranging from very basic to applied immunology. Examples of scientific interests include: Antigen trafficking, processing and presentation by DC, molecular regulation of DC motility, DC-T cell interactions, live imaging of the immune response, regulation of T cell response, cytokine modulation of DC function, anti-tumour immunity, translational immunology and immunotherapy. The department benefit from the high level scientific environment of our Institute in cell and molecular biology, as well as state-of-the-art technological platforms including high-speed 8-colour cell sorting, immuno-histology, timelapse imaging, two-photon and intra-vital microscopy, electron microscopy, proteomics and genomics.