Post-doctoral position in Computational Systems Biology
for the ANR Project “Skin TSLP”, at Institut Curie, Paris, France
The position is open in the frame of the ANR project « Role of the keratinocyte-derived
cytokine Thymic Stromal Lymphopoietin (TSLP) in human skin inflammation “, coordinated
by Dr Vassili Soumelis at Institut Curie, Department of Immunology.
The project:
This project aims at studying the role of the cytokine TSLP in skin inflammation in a global
way: molecular regulation in specific systems and relative function within a complex
inflammatory network reflecting the pathophysiology of atopic dermatitis and other skin
inflammatory diseases. To address these challenging questions, we will use a combination of
in vitro cellular and molecular immunology with systems biology approaches to dissect
transcriptional profiles induced by complex stimuli. The project will be developed in an
interdisciplinary way in collaboration with the Department of Bioinformatics and
Computational Systems Biology of Cancer (Dr E. Barillot).
The post-doctoral fellow will develop and carry out computational systems biology
approaches to identify the factors and molecular pathways leading to TSLP production by
skin keratinocytes, reconstitute TSLP-driven networks relevant to atopic dermatitis, and
characterize the function and dominance of TSLP within a complex inflammatory
environment.
Requirements for the candidates:
We expect a candidate with a PhD in cell biology, immunology, computational biology,
biostatistics or bioinformatics. The successful candidate will have a strong experience in
computational data analysis and modeling in biology. Ideally, the candidate should be able to
demonstrate some knowledge of the biological mechanisms involved in skin inflammation,
and should have experience of interdisciplinary projects mixing, clinics and mathematics.
Some programming skills will be useful (R, Perl). Good knowledge of English both spoken
and written is required.
The position is open immediately and funded for 2 years with possible extension.
Please send CV, letter of motivation and references to bcsb23@curie.fr
For
further
information
please
contact
Vassili.Soumelis@curie.net
Emmanuel.Barillot@curie.fr
and
Mission location: Institut Curie, Paris, « Bioinformatics and Computational Systems
Biology of Cancer » Laboratory and Department of Immunology
Institut Curie (http://www.curie.fr) is one of the biggest European institutions for cancer
research with a strong interdisciplinary tradition. It also comprises a hospital specialized in
cancer treatment, and therefore dispose of a continuum of expertise from fundamental
research to patient care. It is located in the center of Paris in a both cultural and scientific rich
environment.
The Bioinformatics Laboratory of Institut Curie was created in 2003. In January 2008, it has
become an INSERM mixed unit “Bioinformatics and Computational Systems Biology of
Cancer” (Research unit 900 INSERM – Mines ParisTech – Institut Curie) involving about 50
researchers and students, and headed by Dr Emmanuel Barillot. It is a very active and
growing interdisciplinary team of biologists, mathematicians, statisticians, physicists and
computer scientists.
The Immunology Department is headed by Sebastian Amigorena and was initially centered on
the cell biology of dendritic cells (DC). It now gathers 8 groups with complimentary
expertise, ranging from very basic to applied immunology. Examples of scientific interests
include: Antigen trafficking, processing and presentation by DC, molecular regulation of DC
motility, DC-T cell interactions, live imaging of the immune response, regulation of T cell
response, cytokine modulation of DC function, anti-tumour immunity, translational
immunology and immunotherapy. The department benefit from the high level scientific
environment of our Institute in cell and molecular biology, as well as state-of-the-art
technological platforms including high-speed 8-colour cell sorting, immuno-histology, timelapse imaging, two-photon and intra-vital microscopy, electron microscopy, proteomics and
genomics.