13th Annual Meakins-Christie International Workshop Le Chateau Bromont RECENT ADVANCES IN ALLERGY AND ASTHMA February 7-8, 2010 Host: Dr. Qutayba Hamid Coordinator: Maria Makroyanni Chateau Bromont 90, rue Stanstead Bromont, QC Tel: 450-534-4545 GUEST SPEAKERS Dr. Bruce S. Bochner Johns Hopkins University, USA Dr. Redwan Moqbel University of Manitoba, CANADA Dr. Maziar Divangahi McGill University, CANADA Dr. Parameswaran Nair McMaster University, CANADA Dr. Andrew J. Halayko University of Manitoba, CANADA Dr. Marc Peters-Golden University of Michigan, USA Dr. James C. Hogg University of British Columbia, CANADA Dr. Giovanni Piedimonte West Virginia University, USA Dr. Nizar N. Jarjour University of Wisconsin, USA Dr. David Proud University of Calgary, CANADA Dr. Darryl A. Knight University of British Columbia, CANADA Dr. Marc E. Rothenberg University of Cincinnati, USA Dr. Monica Kraft Duke University, USA Dr. Simon Rousseau McGill University, CANADA Dr. Mark Larche McMaster University, CANADA Dr. Robert P. Schleimer Northwestern University, USA Dr. James J. Lee Mayo Clinic, USA Dr. Martin Stämpfli McMaster University, CANADA Dr. Nick Z. Lu Johns Hopkins University, USA Dr. Donata Vercelli University of Arizona, USA Dr. Christine McCusker McGill University, CANADA Dr. Marsha Wills-Karp University of Cincinnati, USA Dr. Zhou Zhu Johns Hopkins University, USA SUNDAY, February 7, 2010 7:00 BREAKFAST 8:00 Welcome/Opening Remarks Dr. Qutayba Hamid 8:15 Studies of inflammation and immunity in the upper airways of patients with chronic rhinosinusitis Dr. Robert P. Schleimer 8:45 Epigenetic regulation of epithelial function in asthma: modifications at the surface or is it a core problem? Dr. Darryl A. Knight 9:15 Virus-epithelium interactions in the airways: RSV vs rhinovirus Dr. Giovanni Piedimonte 9:45 Cigarette smoke extract alters epithelial responses to rhinovirus infection Dr. David Proud 10:15 COFFEE BREAK 10:30 Cross-talk between innate and adaptive immunity to infection Dr. Maziar Divangahi 11:00 Consequences of heterologous exposure to lung inflammatory processes elicited by environmental agents in mice Dr. Martin Stämpfli 11:30 Remodeling of the terminal bronchiales in COPD: a new paradigm based on HRCT and micro-CT Dr. James C. Hogg SUNDAY, February 7, 2010 12:00 Airway remodeling in asthma: modulation by IL-13 Dr. Monica Kraft 12:30 Initiating airway remodeling by allergen bronchoprovocation Dr. Nizar N. Jarjour 1:00 LUNCH 4:00 Eosinophil activities in the lung: you never know where your next idea will come from or how far it will take you! Dr. James J. Lee 4:30 Update on the biology of and ligand for eosinophilexpressed Siglec-8 and Siglec F Dr. Bruce S. Bochner 5:00 Respiratory/esophageal eosinophil axis Dr. Marc E. Rothenberg 5:30 Eosinophils, IDO and tryptophan catabolites in infant human thymus Dr. Redwan Moqbel 6:00 SUPERBOWL DINNER MONDAY February 8, 2010 7:00 BREAKFAST 8:00 Knocking your SOCS off: silencing of SOCS1 by leukotriene B4 is required for optimal macrophage myD88 expression and NFkB activation Dr. Marc Peters-Golden 8:30 Complement regulations of the IL-23 Dr. Marsha Wills-Karp 9:00 Regulation of allergic responses–from men to mice and back Dr. Donata Vercelli 9:30 Association of the S100A8/A9-RAGE axis with airway inflammation, hyperresponsiveness and remodeling Dr. Andrew J. Halayko 10:00 IL-17 promotes p38MAPK-dependent endothelial activation enhancing neutrophil recruitment in vivo Dr. Simon Rousseau 10:30 COFFEE BREAK 10:45 Peptide immunotherapy for the treatment of allergic asthma: immune mechanisms and prospects for the future Dr. Mark Larché 11:15 Teaching tolerance: neonatal immuno-education prevents experimental asthma Dr. Christine McCusker 11:45 Neutrophils in asthma: friends or foe? Dr. Parameswaran Nair MONDAY February 8, 2010 12:15 Tyrosine-phosphatase SHP-1 in mast cell function, immunological homeostasis and allergic and anaphylactic responses Dr. Zhou Zhu 12:45 Glucocorticoid receptor translational isoforms and glucocorticoid sensitivity Dr. Nick Z. Lu 1:15 LUNCH 2:30 DEPARTURES Organized by the Meakins-Christie Laboratories of the McGill University Health Centre – Research Institute We gratefully acknowledge the generous support of: MUHC RI GlaxoSmithKline Canada Merck Frosst Canada AstraZeneca Canada Graceway Canada CSL Behring Nycomed Canada