Patient Information and consent Deep Vein Surgery What is the Post thrombotic syndrome? To understand what happens after a deep vein thrombosis it is necessary to understand how blood flows in the veins of the legs. The Normal leg and valves In a normal leg, blood flows from the foot, back to the heart, through tubes called veins. When you stand up, the blood is prevented from falling back to the ankle by a series of one way valves in the deep veins and superficial veins. The Calf muscle pump In the calf muscle in each leg, there are many veins. As the muscle contracts, when you walk, run, or move the foot, the muscle squeezes the veins and pumps the blood in the vein back towards the heart. This is called the calf muscle pump. It is a bit like a heart for the veins. What happens when a clot forms in the deep vein? This is called a deep vein thrombosis or DVT. Reduced flow in the vein, damage to the wall of the vein or a thickening of the blood can cause blood to clot in the vein. When this happens, no blood can flow through the vein. This means the leg can become hot and swollen as the venous blood can only get back to the heart through small channels. An analogy would be a dam being built across a river bed. The fields that drain into the river would become flooded or water-logged ( the swelling of the leg). The fields can only drain through other streams away from the river. In time, and this varies, the small channels gradually enlarge to carry more of the blood. This is why some people who have had a DVT can develop prominent veins. Some people think these might be varicose veins. If the valves in these veins are working normally, then removing them can make the leg worse. This is why anyone who is going to have varicose vein surgery after a DVT should have a Duplex scan. As the small channels enlarge, the leg swelling can reduce. At the same time, several things can happen to the veins that were affected by the DVT. The human body is good at clearing thrombus by a process called thrombolysis. If all the thrombus is cleared then the deep veins may be undamaged. In many people who have had a DVT, the thrombus leaves scars within the vein. This scarring can damage the valves and narrow the diameter of the veins. What problems does scarring of the veins cause? Aching legs and swollen legs. If the valves in the deep veins are damaged then blood runs in the wrong direction, towards the ankle. This puts extra pressure on the ankle's blood vessels which means the leg can swell. Many people with this problem of incompetent deep veins ( valves that do not work) have pain in their leg when they stand up. The pain can get worse as the day continues. They only get relief when they lie down again. Some people have a feeling of a rush of blood into the calf when the deep veins are incompetent. Failure of the calf pump. The scarring of the veins can narrow their diameter. This means the calf muscle can only pump small amounts of blood out of the leg. This makes it difficult to pump the blood from the leg. When the incompetent valves and failed calf pump are combined, the leg can become increasingly swollen and painful. This condition is the Post-Thrombotic or PostPhlebitic Syndrome. What can happen if I develop the Post-Thrombotic Syndrome? Apart from the aching and swelling of the leg, there can be changes in the colour of the skin of the leg. Ultimately, the skin of the leg can become so damaged that an ulcer develops. The leg can change in appearance to look a little like an upside down champagne bottle. Can anything be done to help? The most important thing to do is to prevent the deep vein thrombosis in the first place. When a DVT has occurred, it may be possible to remove the thrombus by dissolving it or removing it surgically. Most doctors will, however, suggest that the DVT is treated by anticoagulation ( thinning of the blood) with an injection called heparin or a tablet called warfarin. If you have the post-thombotic syndrome, you will have been advised to wear some form of compression stocking. These can help the swelling and pain. Some patients cannot or do not want to wear stockings. For these patients it may be possible to correct the deep vein problems with an operation. What are the Benefits of Deep Vein Surgery? If the operation is successful, you should be able to stand without a feeling of heaviness in the leg. If you have an ulcer, there is a greater chance that it will heal and stay healed. Any swelling of the ankle should reduce and you may be able to walk more easily. You have been given this information sheet as you are thought to be suitable for deep vein surgery. Are there alternatives to surgery? You may have already tried wearing special compression stockings. If not, this is the only alternative to surgery. What will happen if I decide not to have the operation for my deep veins? You will have to continue as you are. If you are not using compression stockings, you will be advised to wear them. What does the operation involve? A variety of anaesthetic techniques are possible. Your anaesthetist will discuss the options with you and will recommend what they think is best for you. Your surgeon will make a cut in your groin over the common femoral vein. They may make other cuts on your leg depending on the results of your tests (Duplex scan, plethysmography and venography). Your surgeon will use part of a vein in your leg to build a new valve or move an existing valve. The aim is to stop the blood in the vein from passing in the wrong direction as it does now. At the end of the operation, your surgeon will close the skin with stitches or clips. After the operation you will need to lie in bed for 3 days with your leg raised. You will be started on a medicine called warfarin to thin the blood. When the level of warfarin is correct and you are comfortable, you will go home. This is usually 5 to 10 days after the operation. If you cannot take Warfarin, other medicines can be given using injections. What risks or complications can happen? We try to make sure your operation is safe. This may include prescribing medicines to reduce the riks of complications. Most operations are successful with few complications. However, every procedure has risks and potential complications. Those most relevant to this operation are listed below. Please discuss them with your doctor if there is anything you do not understand. The risks and complications fall in to 3 categories: 1. 2. 3. Complications of anaesthesia General Complications of any operation Specific Complications of deep vein surgery. The specific complications of deep vein surgery include: Deep vein thrombosis can occur if the blood clots at the site of the operation. You will be given blood-thinning medicines called Heparin and Warfarin to reduce the risk of this happening. You will need to take the Warfarin ( or injections) for 3 months. This might affect any medicines you take and your alcohol consumption. Swelling of the leg can occur for a few weeks because the glands in the groin may be damaged ( Lymphatics). Rarely the swelling can be permanent. Neuralgia and pain can occur if the femoral nerve is damaged in the groin. This usually gets better on its own. Sometimes medicine or an operation is required to help the pain of the neuralgia Fluid collection under the wound (seroma), which leads to a continued leak of fluid. This usually settles with time. Loss of the leg can occur if the operation fails to work or makes the condition of the leg worse. This is highly unlikely but theoretically possible. You need to consider how bad your symptoms are and whether you wish to take this very small risk. How soon will I recover? After the operation you will be transferred to the recovery room and then to the ward. You will be able to drink and eat after the anaesthetic wears off. You will be given painkillers to control the pain and keep you comfortable. Most patients stay in hospital for 5 to 10 days. However, your doctor may recommend that you stay a little longer. Returning to normal activities Your surgeon will advise when you can resume normal activities. Are the benefits and risks of deep vein surgery clear? No, they are not. Most of the procedures used in the NHS are not new, and we have learnt how well they work and what risks they have. Some procedures, like deep venous surgery, are too new to have all the information we need. We are not yet sure just how much benefit deep vein surgery can give and which patients get the most from the operation. We know the short-term results of some of the operations but not the long-term ones. Research has shown that some forms of deep vein surgery ( New Valve construction) work well after one year. Other types of deep vein surgery (transposition and valvuloplasty) continue to work after 5 years in half of the patients who have been treated. All procedures have side effects and risks. It may take some time to discover exactly what the problems are with Deep vein Surgery and how common they are. It may be right to choose a procedure for which the benefits and risks are uncertain if doctors think it is likely to help a patient, and the patient agrees, knowing the outcomes are uncertain – but we must take special care when we have not got all the answers about the procedure. This is the case for deep vein surgery. Who decides about the use of deep venous surgery? The National Institute For Clinical Excellence (NICE) can help. NICE is part of the NHS, and its role is to provide patients, health professionals and the public with guidance on treatment and care for people using the NHS. As part of its work, NICE looks into new procedures which have been notified to it and decides whether we know enough about how well they work, and how safe they are, to use them routinely. NICE was asked about Deep Venous Surgery by the Nottingham Surgeons, in 2005. Further Information You can get more information from: Patient Advice and Liason service (PALS) on 0800 123 0204 Mr Braithwaite’s web site: www.bdb.org.uk NICE: www.nice.org.uk