biographical sketch - University of Colorado Denver

Andrea Steck, MD
Assistant Professor of Pediatrics, Barbara Davis
Center for Childhood Diabetes
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as
nursing, and include postdoctoral training.)
University of Lausanne, Switzerland
University of Geneva, Switzerland
University of Colorado School of Medicine,
Denver, CO
Pediatric Endocrinology
A. Personal Statement
My primary research focus is in the area of genetics, epidemiology and prevention of type 1 diabetes. I have a
background in pediatric endocrinology, with specific training and expertise in pediatric diabetes. My prior
research experience includes work with epidemiological studies such as DAISY (Diabetes Autoimmunity Study
in the Young) and genetic studies such as T1DGC (Type 1 Diabetes Genetics Consortium). At this time, I am
the PI for a JDRF funded study looking at extreme risk for type 1 diabetes in DR3/4-DQ8 subjects (Genetic
Analysis and Biobank). I am also involved in prevention studies such as the TrialNet Oral Insulin Trial. In the
last few years, I have worked with investigators from DAISY and T1DGC to evaluate contribution of HLA and
non-HLA genes (INS, CTLA-4, PTPN22) to type 1 diabetes genetic risk. I am the PI for the CYPRESS study
(C-peptide in the Young Preservation Study) looking at preservation of C-peptide over time in children
diagnosed with type 1 diabetes through prospective studies such as DAISY and TEDDY compared to a group
of age matched type 1 diabetes controls from the community. I am also the PI of the Monogenic Diabetes
study at the Barbara Davis Center, investigating monogenic forms of diabetes. In summary, I have a
demonstrated record of successful and productive research projects in collaboration with local and national
colleagues with the DAISY, T1DGC and TrialNet studies. My expertise and experience have prepared me to
serve as a contributing investigator in the proposed project.
B. Positions and Honors.
Positions and Employment
Pediatric Residency, University Hospital of Geneva, Switzerland
Pediatric Chief Resident, University Hospital of Geneva, Switzerland
Postdoctoral Fellow, Barbara Davis Center for Childhood Diabetes, Denver, CO
Pediatric Endocrinology Fellow, University of Colorado, Denver, CO
Instructor of Pediatrics, University of Colorado Denver, The Barbara Davis Center for Childhood
Diabetes and The Children’s Hospital
2010-present Assistant Professor of Pediatrics, University of Colorado Denver, The Barbara Davis Center for
Childhood Diabetes and The Children’s Hospital
Professional Societies
2000Swiss Pediatric Society
2006Lawson Wilkins Pediatric Endocrine Society
2007The Endocrine Society
2008American Diabetes Association
C. Selected peer-reviewed publications
Most relevant to the current application (up to 5)
1. Steck AK, Barriga KJ, Emery LM, Fiallo-Scharer RV, Gottlieb PA, Rewers MJ. “ Secondary attack rate
of type 1 diabetes in Colorado families”. Diabetes Care. 2005 Feb;28(2):296- 300.PMID: 15677782.
2. Steck AK, Bugawan TL, Valdes AM, Emery LM, Blair A, Norris JM, Redondo MJ, Babu SR, Erlich HA,
Eisenbarth GS, Rewers MJ. “Association of Non-HLA Genes With Type 1 Diabetes Autoimmunity”.
Diabetes. 2005 Aug;54(8):2482-6. PMID: 16046318.
3. Steck AK, Zhang W, Bugawan TL, Barriga KJ, Blair A, Erlich HA, Eisenbarth, GS, Norris JM and
Rewers MJ. “Do non-HLA Genes Influence Development of Persistent Islet Autoimmunity and Type 1
Diabetes in Children with High-Risk HLA-DR,DQ Genotypes?” Diabetes. 2009 Apr;58(4):1028-33.
PMID 19188433; PMCID 2661592
4. Steck AK, Armstrong TK, Babu SR, Eisenbarth GS; T1DGC. Stepwise or linear decrease in penetrance
of type 1 diabetes with lower-risk HLA genotypes over the past 40 years. Diabetes. 2011 Mars; 60 (3):
1045-1049. PMID 21307077
5. Steck AK, Johnson K, Barriga KJ, Miao D, Yu L, Hutton JC, Eisenbarth GS, Rewers MJ. Age of Islet
Autoantibody Appearance and Mean Levels of Insulin, but Not GAD or IA-2 Autoantibodies, Predict Age
of Diagnosis of Type 1 Diabetes: Diabetes Autoimmunity Study in the Young. Diabetes Care. 2011
Jun;34(6):1397-9. Epub 2011 May 11. PMID:21562325
Additional recent publications of importance to the field (up to 10)
1. Steck AK, Rewers MJ. Genetics of Type 1 Diabetes. Clinical Chem. 2011 Feb; 57(2): 176-85. Epub
2011 Jan 4. Review. PMID: 21205883
2. Aly TA, Ide A, Humphrey K, Barker JM, Steck A, Erlich HA, Yu L, Miao D, Redondo MJ, McFann K,
Roberts CM, Babu SR, Norris JM, Eisenbarth GS, Rewers MJ. “Genetic Prediction of autoimmunity:
Initial oligogenic prediction of anti-islet autoimmunity amongst DR3/DR4-DQ8 relatives of patients with
type 1A diabetes”. J Autoimmun. 2005;25 Suppl:40-5. Epub 2005 Oct 19. PMID: 16242305.
3. Steck AK, Baschal EE, Jasinski JM, Boehm BO, Bottini N, Concannon P, Julier C, Morahan G, Noble
JA, Polychronakos C, She JX, Eisenbarth GS and the T1DGC. “rs2476601 Allele T (R620W) Defines
High Risk PTPN22 Diabetes Associated Haplotypes with Preliminary Evidence for an Additional
Protective Haplotype”. Genes Immun. 2009 Dec;10, S21–S26. PMID: 19956096; PMCID:2805459.
4. Steck AK, Liu SY, McFann K, Barriga KJ, Babu SR, Eisenbarth GS, Rewers MJ, She JX. “ Association
of the PTPN22/LYP gene with Type 1 Diabetes”. Pediatric Diabetes. 2006 Oct;7(5):274-8. PMID:
5. Steck AK and Eisenbarth GS. “Genetic similarities between latent autoimmune diabetes and type 1 and
type 2 diabetes”. Diabetes. 2008 May; 57(5):1160-2. PMID: 18443373.
6. Yu J, Steck AK, Babu S, Yu L, Miao D, McFann K, Hutton J, Eisenbarth GS, Klingensmith GJ. “Single
Nucleotide Transcription factor 7-like 2 (TCF7L2) Gene Polymorphisms in Anti-Islet Autoantibody
Negative Patients at Onset of Diabetes”. J Clin Endocrinol Metab. 2008 Dec 2. PMCID: 2646512.
7. Liu S, Wang H, Jin Y, Podolsky R, Reddy MV, Pedersen J, Bode B, Reed J, Steed D, Anderson S,
Yang P, Muir A, Steed L, Hopkins D, Huang Y, Purohit S, Wang CY, Steck AK, Montemari A,
Eisenbarth G, Rewers M, She JX. “IFIH1 Polymorphisms Are Significantly Associated with Type 1
Diabetes and IFIH1 Gene Expression in Peripheral Blood Mononuclear Cells”. Hum Mol Genet. 2009
Jan 15;18(2):358-65. PMID 18927125; PMCID2638779
8. Baschal EE, Aly TA, Jasinski JM, Steck AK, Johnson KN, Noble JA, Erlich HA, Eisenbarth GS;
Diabetes Genetics Consortium. “The frequent and conserved DR3-B8-A1 extended haplotype confers
less diabetes risk than other DR3 haplotypes”. Diabetes Obes Metab. 2009 Feb;11 Suppl 1:25-30.
PMID: 19143812; PMCID: 2769935.
9. Baschal EE, Aly TA, Jasinski JM, Steck AK, Noble JA, Erlich HA, Eisenbarth GS; Type 1 Diabetes
Genetics Consortium. “Defining Multiple Common “Completely” Conserved Major Histocompatibility
Complex SNP Haplotypes”. Clinical Immunol. 2009 Aug;132(2):203-14. PMID: 19427271.
10. The Past, Present, and Future of Genetic Associations in Type 1 Diabetes. Baker PR 2nd, Steck AK.
Curr Diab Rep. 2011 Jul 27. [Epub ahead of print] PMID: 21792535
D. Research Support
Ongoing Research Support
Gottlieb (PI)
Principal Investigator of the UC TrialNet Affiliate Site: Peter Gottlieb, MD
TrialNet: Diabetes Type 1 Prevention
Role: PI of the TrialNet Oral Insulin Trial
The goal of this project is to look at possible prevention of type 1 diabetes with oral insulin treatment.
Steck (PI)
03/01/2010- 02/28/2013
Genetic Analysis and Biobank of DR3/4-DQ8: Extreme Risk for Type 1 Diabetes
The goal of this project is to look at genetic risk prediction for type 1 diabetes in DR3/4-DQ8 subjects.
Role: PI
R37 DK32493 NIH, NIDDK
Rewers (PI)
Principal Investigator: Marian Rewers, MD, PhD
Natural History of Pre-Diabetic Autoimmunity/Diabetes Autoimmunity Study in the Young (DAISY)
To determine age-specific incidence of islet autoimmunity, risk factors, and determinants of progression to
Role: co-investigator
Completed Research Support
Steck (PI)
NIH Autoimmune Prevention Center pilot proposal
Cooperative Study Group for Autoimmune Disease Prevention
Next generation sequencing to define triggering pathogens of type 1 diabetes.
Role: PI
Dabelea (PI)
WFUSM SEARCH.FC (SEARCH for Diabetes in Youth: Monogenic Diabetes)
Role: Co-Investigator
K12 DK063722
Klingensmith (PI)
NIH/NIDDK, Mentor Based Award
Award for continued research development in diabetes for junior faculty in pediatric
Role: Co-investigator