BIOGRAPHICAL SKETCH
NAME
Christopher William McIntyre
TITLE
Dr
DATE OF BIRTH
09/06/1966
Place of Birth (Country)
U.K.
Present Nationality
British
Male
Degrees/Diplomas
MBBS (London)
MRCP
MD (London)
Year Conferred
1990
1993
1999
Research and/or professional experience

Associate Professor and Reader in Vascular Medicine, School of Graduate Entry Medicine and
Health, University of Nottingham
June 2006 to date

Consultant Nephrologist, Derby Hospitals NHS Foundation Trust
July 1999 – June 2006

Lecturer in Renal Medicine, Royal London Hospitals
1995 – 1999

Renal Registrar, UCH rotation
1994 -1995
Dr McIntyre leads the University of Nottingham’s Renal Research Group. This relatively new, but
rapidly maturing, research group has developed unique novel insights into the pathophysiology of the
most common causes of death in patients with CKD, and has generated important changes in clinical
practice, including work directly directed at dialysis related infection and CV tolerability of dialysis.
Since 2002 Dr McIntyre has supervised 13 higher degree students. The current team consists of nine
research fellows, all registered for PhD study. Since 2002, we have consistently raised significant
amounts of research-dedicated income from both commercial and competitive charitable sources,
including NIHR (total around £1.7m), and currently am the PI on five investigator initiated UKCRN
portfolio registered studies (current accrual 1300 patients). The renal group alone has published more
than 75 peer reviewed original articles/ invited reviews (50 in last three years alone).
Recent relevant publications
McIntyre CW et al. Haemodialysis Induced Cardiac Dysfunction is associated with an Acute Reduction
in Global and Segmental Myocardial Blood Flow. Clin J Am Soc Nephrol. 2008 Jan;3(1):19-26
McIntyre CW et al. Iron-magnesium hydroxycarbonate (fermagate): a novel non-calcium-containing
phosphate binder for the treatment of hyperphosphatemia in chronic hemodialysis patients. Clin J Am
Soc Nephrol epub 2009
Burton JO, Jefferies HJ, Selby NM, McIntyre CW.
Haemodialysis induced cardiac injury: determinants and associated outcomes.
Clin J Am Soc Nephrol In press 2009
Sigrist MK, Taal MW, Bungay P, McIntyre CW.
Progressive vascular calcification in patients with stages 4 and 5 chronic kidney disease.
Clin J Am Soc Nephrol. 2007 Nov;2(6):1241-8
Chan C, Smith D, Spanel P, McIntyre CW, Davies SJ.
A non-invasive, on-line deuterium dilution technique for the measurement of total body water in
haemodialysis patients.
Nephrol Dial Transplant. 2008 Jun;23(6):2064-70.
Recent Grants Awarded
Kidney Research UK (co applicant with Prof Simon Davies)
Studies of body water using deuterium abundance analysis of breath and dialysate headspace in
the individualisation of haemodialysis treatment. £68,000 (awarded 2005)
Kidney Research UK/ British Renal Society (fellowship)
Determinants and cardiovascular consequences of vascular calcification in CKD patients
£55,000 (awarded 2005)
Dialysis-induced myocardial stunning – a possible mechanism for heart failure? Kidney Research
UK, £56,000 (awarded 2006).
Study to investigate the effects of cool dialysate on systemic haemodynamics and myocardial stunning,
British Renal Society, £30,000 (awarded 2006).
Investigation of optimal reduction in dialysate temperature on systemic haemodynamics and myocardial
stunning, British Renal Society, £50,000 (awarded 2007).
An Investigation Into The Occurrence of Myocardial Stunning During Paediatric Dialysis And Its
Resolution Following Transplantation, Kids Kidney Research (co applicant with Dr Lesley Rees) £68,000
(awarded 2007).
Cardiovascular and Functional Consequences of Chronic Kidney Disease in Older People, British Renal
Society, £56,000 (awarded 2008).
Dialysate magnesium concentration – a novel tool to abrogate dialysis-induced myocardial stunning?
Kidney Research UK, £36,000 (awarded 2008).
Defining the risk of renal function decline and cardiovascular disease among patients with chronic
kidney disease stage 3 in primary care: The Renal Risk in Derby Study. KRUK/British Renal Society (co
applicant) £50,000 (awarded 2009).
Dialysis induced cardiac injury: study of pathophysiological mechanisms and novel treatments. KRUK
£98,000 (awarded 2009)
Study of dialysate cooling to prevent the development of heart failure in chronic haemodialysis patients.
NIHR £233,000 (awarded 2009)
Total £802,000