简历
朱强 博士
中国科学院广州生物医药与健康研究院, 广州市科学城开源大道190号 510530
电话：020-32015287，或 186-8888-3282. 传真：020-32015299.
Email: zhu_qiang@gibh.ac.cn
研究经历:
2008年5月 至今
中国科学院广州生物医药与健康研究院 PI，研究员
(自2010年起兼呼吸疾病国家重点实验室PI)
2005年9月 至 2008年2月
美国公司 XTL Biopharmaceuticals Inc. 产品研究和开发部staff scientist
从事抗丙肝药物研究和开发
2001年4月 至 2005年9月
美国公司 Vivoquest, Inc. 产品研究和开发部staff scientist
从事类天然产物小分子合成方法研究，用于抗病毒药物的开发
2000年8月 至 2001年4月
美国科罗拉多州立大学化学系博士后
导师 Marc M. Greenberg 教授
研究方向：设计和合成 DNA 尿嘧啶糖基化酶自杀性抑制剂 (Suicide Inhibitor of
Uracil DNA Glycosylase，UDG)。
教育背景：
1995年9月 至 2000年6月
中国科学院上海有机化学研究所生命有机国家重点实验室博士学位
导师：吴毓林研究员
研究方向：海洋天然产物群蛀虫内酯(Clavulactone)的全合成研究。
1991年9月 至 1995年6月
南京大学化学化工学院本科学位
获奖情况:
1998年，上海有机化学研究所首届刘铸晋奖
2011年，中国科学院“百人计划”
2012年，中科院广州教育基地优秀研究生导师
2012年，中科院优秀研究生导师奖
研究领域及兴趣:
简历
（1）C−H键官能化反应用于杂环化合物合成方法研究；（2）Cu/O2 体系对有
机小分子的选择性氧化；（3）异腈参与的新反应研究；（4）药物分子合成工
艺的改进；（5）抗肺癌，抗肺结核药物开发。
发表论文：
独立工作以后：
2013年
1. Synthesis of phenanthridinones via palladium-catalyzed C(sp2)−H
aminocarbonylation of unprotected o-arylanilines
Dongdong Liang, Ziwei Hu, Jiangling Peng, Jinbo Huang, and Qiang Zhu*
Chem. Commun. 2013, 49, 173-175.
2. Synthesis of 10-Methylacridin-9(10H)-ones through Cu-Catalyzed Intramolecular
Oxidative C(sp2)−H Amination of o-N-methylaminobenzophenones
Jinbo Huang, Congqing Wan, Ming-Fang Xu,* and Qiang Zhu*
Eur. J. Org. Chem. 2013, 1876-1880.
3. C–H cycloamination of N-aryl-2-aminopyridines and N-arylamidines catalyzed by
an in situ generated hypervalent iodine(III) reagent
Yimiao He, Jinbo Huang, Dongdong Liang, Lanying Liu and Qiang Zhu*
Chem. Commun. 2013, 49, 7352-7354.
4. A Metal-Free Tandem Demethylenation/C(sp2) −H Cycloamination Process of N‑
Benzyl-2-aminopyridines via C- C and C- N Bond Cleavage
Dongdong Liang, Yimiao He, Lanying Liu, and Qiang Zhu*
Org. Lett. 2013, 15, 3476-3479.
5. A Transition-Metal-Free Synthesis of Arylcarboxyamides from Aryl Diazonium
Salts and Isocyanides
Zhonghua Xia and Qiang Zhu*
Org. Lett. 2013, 15, 4110-4113.
2012 年
1. Direct carboxamidation of indoles by palladium-catalyzed C−H activation and
isocyanide insertion
Jiangling Peng, Lanying Liu, Ziwei Hu, Jinbo Huang, Qiang Zhu*
Chem. Commun. 2012, 48, 3772-3774.
2. Cu-Catalyzed Oxidative C(sp2)−H Cycloetherification of o-Arylphenols for the
Preparation of Dibenzofurans
Jiaji Zhao, Yong Wang, Yimiao He, Lanying Liu, Qiang Zhu*
Org. Lett. 2012, 14, 1078-1081.
3. Cu-Catalyzed Regioselective C−H Aerobic Oxidative Cycloetherification of oArylphenols Bearing an Additional Directing Group
Jiaji Zhao, Yong Wang, Qiang Zhu*
Synthesis 2012, 44, 1551-1555.
简历
4. Palladium(II)-Catalyzed Cycloamidination via C(sp2)-H Activation and Isocyanide
Insertion
Yong Wang, Qiang Zhu*
Adv. Synth. Catal. 2012, 354, 1902-1908.
5. Palladium-catalyzed cyclization of o-alkynyltrifluoroacetanilides followed by
isocyanide insertion: synthesis of 2-substituted 1H-indole-3-carboxamides
Ziwei Hu, Dongdong Liang, Jiaji Zhao, Jinbo Huang, and Qiang Zhu*
Chem. Commun. 2012, 48, 7371-7373.
6. Palladium-Catalyzed C(sp2)−H Cyanation Using Tertiary Amine Derived
Isocyanide as a Cyano Source
Jiangling Peng, Jiaji Zhao, Ziwei Hu, Dongdong Liang, Jinbo Huang, and Qiang
Zhu*
Org. Lett. 2012, 14, 4966-4969.
7. CuI-Mediated Sequential Iodination/Cycloetherification of o-Arylphenols:
Synthesis of 2- or 4-Iododibenzofurans and Mechanistic Studies
Jiaji Zhao, Qi Zhang, Lanying Liu, Yimiao He, Jing Li, Juan Li,* and Qiang Zhu*
Org. Lett. 2012, 14, 5362-5365.
8. Synthesis of Benzimidazoles by PIDA-Promoted Direct C(sp2)−H Imidation of NArylamidines
Jinbo Huang, Yimiao He, Yong Wang, and Qiang Zhu*
Chem. Eur. J. 2012, 18, 13964-13967.
2011 年
1. Palladium-Catalyzed Intramolecular C(sp2)–H Amidination by Isonitrile Insertion
Provides Direct Access to 4-Aminoquinazolines from N-Arylamidines
Yong Wang, Honggen Wang, Jiangling Peng, Qiang Zhu*
Org. Lett. 2011, 13, 4604-4607..
2. Bronsted Acid-Promoted Sequential Hydroarylation-Hydroamidation of Arene
Tethered 1-(2-Alkynylphenyl)ureas: Direct Access to 4,4-spiro-3,4-dihydro-2-(1H)quinazolinones
Honggen Wang, Jiaji Zhao, Jiancun Zhang*, Qiang Zhu*
Adv. Synth. Catal. 2011, 2653-2658.
3. Sequential Hydration–Condensation–Double Cyclization of PyridineSubstituted 2-Alkynylanilines: An Efficient Approach to Quinoline-Based
Heterocycles
Lijie Peng, Honggen Wang, Changlan Peng, Ke Ding,* Qiang Zhu*
Synthesis 2011, 1723-1732.
4. Synthesis of Quinazolin-4(3H)-ones via Pd(II)-Catalyzed Intramolecular
C(sp2)−H Carboxamidation of N-arylamidines
Bin Ma, Yong Wang, Jiangling Peng, Qiang Zhu*
简历
J. Org. Chem. 2011, 76, 6362-6366.
5. Copper-Catalyzed Intramolecular Dehydrogenative Aminooxygenation: Direct
Access to Formyl-Substituted Aromatic N-Heterocycles
Honggen Wang, Yong Wang, Dongdong Liang, Lanying Liu, Jiancun Zhang,* Qiang
Zhu*
Angew. Chem., Int. Ed. 2011, 50, 5678-5681.
2010 年
1. Synthesis of 2-Alkoxy(aroxy)-3-substituted Quinolines by DABCO-Promoted
Cyclization of ortho-Alkynylaryl Isocyanides
Jiaji Zhao, Changlan Peng, Lanying Liu, Yong Wang, Qiang Zhu*
J. Org. Chem. 2010, 75, 7502-7504.
2. A Direct Intramolecular C−H Amination Reaction Co-Catalyzed by Copper(II) and
Iron(III) as Part of an Efficient Route for the Synthesis of Pyrido[1,2a]benzimidazoles from N-Aryl-2-aminopyridines
Honggen Wang, Yong Wang, Changlan Peng, Jiancun Zhang*, Qiang Zhu*
J. Am. Chem. Soc. 2010, 132, 13217-13219.
3. p-Toluenesulfonic Acid Promoted Annulation of 2-Alkynylanilines with Activated
Ketones: Efficient Synthesis of 4-Alkyl-2,3-Disubstituted Quinolines
Changlan Peng, Yong Wang, Lanying Liu, Honggen Wang, Jiaji Zhao, Qiang Zhu*
Eur. J. Org. Chem. 2010, 818-822.
4. Structure-based design, synthesis and biological evaluation of new Ncarboxyphenylpyrrole derivatives as HIV fusion inhibitors targeting gp41
Yong Wang, Hong Lu, Qiang Zhu*, Shibo Jiang*, Yun Liao*
Bioorg. Med. Chem. Lett. 2010, 20, 189-192.
2009 年
1. An efficient synthesis of 4-alkyl-2(1H)-quinazolinones and 4-alkyl-2chloroquinazolines from 1-(2-alkynylphenyl)ureas
Honggen Wang, Lanying Liu, Yong Wang, Changlan Peng, Jiancun Zhang*, Qiang
Zhu*
Tetrahedron Lett. 2009, 50, 6841-6843.
2. Tetrabutylammonium chloride-triggered 6-endo cyclization of oalkynylisocyanobenzenes: an efficient synthesis of 2-chloro-3-substituted quinolines
Lanying Liu, Yong Wang, Honggen Wang, Changlan Peng, Jiaji Zhao, Qiang Zhu*
Tetrahedron Lett. 2009, 50, 6715-6719.
3. Sulfuric acid promoted condensation cyclization of 2-(2(trimethylsilyl)ethynyl)anilines with arylaldehydes in alcoholic solvents: an efficient
one-pot synthesis of 4-alkoxy-2-arylquinolines
Yong Wang, Changlan Peng, Lanying Liu, Jiaji Zhao, Li Su, Qiang Zhu*
Tetrahedron Lett. 2009, 50, 2261-2265.
简历
独立工作以前：
1. Diversity Oriented Synthesis and Branching reaction Pathway to Generate Natural
Product-like compounds.
Yun Liao, Youhong Hu, Jie Wu, Qiang Zhu, Maryann Donovan, Reza Fathi, Zhen
Yang*
Curr. Med. Chem. 2003, 10, 2285-2316.
2. Palladium-catalyzed Cross-Coupling Reactions of 4-Tosyl-2(5H)-furanone with
Boronic Acids: A Facile and Efficient Route to Generate Substituted 2(5H)-furanones
Jie Wu,* Qiang Zhu, Lisha Wang, Reza Fathi, Zhen Yang*
J. Org. Chem. 2003, 68, 670.
3. Phenyliodonium Zwitterion as an Efficient Electrophile in the Palladium-Catalyzed
Suzuki-type Reaction: a Novel Method for the Synthesis of 3-Aryl-4-ydroxycoumarins
Qiang Zhu,* Jie Wu, Reza Fathi, Zhen Yang*
Org. Lett. 2002, 4, 3333-3336.
4. Observation and Elimination of N-Acetylation of Oligonucleotides Prepared Using
Fast-Deprotection Phosphoramidites and Ultra-Mild Deprotection
Qiang Zhu, Michael O. Delaney, Marc M. Greenberg*
Bioorg. Med. Chem. Lett. 2001, 11, 1105-1107.
5. Studies toward the Total Synthesis of Clavulactone
Qiang Zhu, Lixin Qiao, Yikang Wu, Yu-Lin Wu*
J. Org. Chem. 2001, 66, 2692-2699.
6. Radical-Mediated Diastereoselective Construction of a Chiral Synthon for
Synthesis of Dolabellanes
Qiang Zhu, Kai-Yi Fan, Hong-Wei Ma, Li-Xin Qiao, Yu-Lin Wu,* Yikang Wu*
Org. Lett. 1999, 1, 757-759.
7. Radical-Mediated Construction of Cyclopentane with Concurrent Formation of a
Well-Defined Quaternary Center
Qiang Zhu, Li-Xin Qiao, Yikang Wu, Yu-Lin Wu*
J. Org. Chem. 1999, 64, 2428-2432.
专利：
1. Jie Wu, Zhen Yang, Reza Fathi, Qiang Zhu, Lisha Wang “4-Thio-Coumarins" US
Patent 6 703 514, 2004.
2. Jie Wu, Zhen Yang, Reza Fathi, Qiang Zhu “4-Thio-Coumarins" US Patent 7 148
253 2006.
3. Bin Xu, Qiang Zhu, Hyun-Joon Cho, Reza Fathi, Zhen Yang, Anthony Sandrasagra,
Yixin Liu “3,4-Disubstituted Coumarin and Quinolone Compounds” Wipo Patent
WO/2007/133211.
简历
4. Zhen Yang, Reza Fathi, Qiang Zhu, Hyun Joon Cho, Yixin Liu, Anthony
Sandrasagra, Richard Wobbe “4-Thio Substituted Quinoline and Naphthyridine
Compounds” Wipo Patent WO/2008/024423
5. Guolin Li, Reza Fathi, Zhen Yang, Yun Liao, Qiang Zhu, Angela Lam, Anthony
Sandrasagra, Kenneth Nawoschik, Hyun Joon Cho, Jie Cao, Ruoqiu Wu, Richard
Wobbe “Compounds and Methods for Treatment of HCV” Wipo Patent
WO/2008/048589 A2.
6. 吴东海, 朱强, 杨松, 刘兰英, 彭长兰. 青蒿素衍生物的新应用，
ZL201010216620.0
7. 朱强, 王洪根, 王勇, 梁冬冬, 刘兰英, 张健存. 咪唑[1,2-a]吡啶和咪唑醛类化合
物的新合成方法, 专利号：201110110748.3
承担课题：
1．国家自然科学基金科学部主任基金（20942001）“异腈参与的多取代喹啉的
合成研究”，2009年1月至2009年12月，8 万元，已结题。
2．广州市科技计划项目（2010Y1-C241）“以邻炔基苯胺为原料合成几类重要
的含氮杂环”，2011年1月至2011年12月，6万元，已结题。
3．国家自然科学基金面上项目（21072190）“通过分子内C-H键官能化合成几
类杂环化合物的新方法研究”， 2011年1月至2013年12月，36万元。
4. 2011年广东省自然科学基金重点项目(S2011020000806)“铜/氧气体系催化的烯
烃脱氢氧胺化反应极其应用研究”，2011年1月至2013年12月，30万元。
5. 国家自然科学基金面上项目(21272233)“高价碘试剂催化的氧化环化反应研
究”, 2013年至2016年, 80 万元.
6．国家自然科学基金青年基金(21202167) “铜/氧气体系催化的烯烃脱氢氧胺
化反应研究” 2013年至2015年，25 万元，课题组成员主持。