CURRICULUM VITAE EDWARD H. KAROTKIN, M.D. DATE OF BIRTH: 18 FEBRUARY 43 PLACE OF BIRTH: HARTFORD, CONNECTICUT MARITAL STATUS: MARRIED TO BETSY LYNN OASIS - 3 CHILDREN EDUCATION AND TRAINING: 1961 – 1965 B.S. Degree, Union College Schenectady, New York 1966 - 1967 Masters Program in Microbiology University of Denver Denver, Colorado 1967 - 1971 M.D. Degree Bowman Gray School of Medicine Winston-Salem, North Carolina 1971 - 1972 Pediatric Intern Mt. Sinai Hospital New York, New York 1972 - 1973 Pediatric Resident Mt. Sinai Hospital New York, New York 1973 - 1975 Neonatology Clinical and Research Fellow Providence Lying-In Hospital Brown Medical School Providence, Rhode Island 1975 - 1977 Major, Medical Corps United States Army Moncrief Army Hospital Columbia, South Carolina 1 APPOINTMENTS AND POSITIONS: 1977 - 1978 Co-Director of Nurseries Ochsner Foundation Hospital New Orleans, Louisiana 1978 - 1983 Assistant Professor of Pediatrics Eastern Virginia Medical School Norfolk, Virginia 1978 - 1984 Neonatologist Children’s Hospital of The King’s Daughters Norfolk, Virginia 1983 - 1991 Associate Professor of Pediatrics Eastern Virginia Medical School Norfolk, Virginia 1991 - Present Professor of Pediatrics Eastern Virginia Medical School Norfolk, Virginia 1984 - 1998 Division Director, Neonatal-Perinatal Medicine Children’s Hospital of The King’s Daughters Norfolk, Virginia 1984 - 1998 Co-Director of Regional Perinatal Council 1998 - 2010 Community Outreach Medical Coordinator Children’s Health Systems Children’s Hospital of The King’s Daughters Norfolk, Virginia 1998 - 2010 Medical Director, Neonatal-Perinatal Outreach Center of Virginia and North Carolina Children’s Hospital of The King’s Daughters Norfolk, Virginia 1998 – Present Medical Director, Resource Mothers Program, Children’s Hospital Of the King’s Daughters, Norfolk, VA 2005 – Present Chief Medical Officer – The Assist Group 2 MEMBERSHIP IN SOCIETIES AND PROFESSIONAL ORGANIZATIONS: Alpha Omega Alpha Southern Medical Society, 1977 Southern Perinatal Association, 1979 The American Academy of Pediatrics, 1979 Tidewater Pediatric Society, 1979 Southern Society for Pediatric Research, 1980 American Medical Association, 1980 Virginia Perinatal Association Fetus & Newborn Committee, Virginia Chapter, AAP Commonwealth of Virginia, Perinatal Services Advisory Board, Governor appointment, 1985 Virginia - Israel Advisory Board, Commonwealth of Virginia, Governor appointment, 1996 Virginia Maternal and Child Health Council, Governor Appointment, 1998 HONORS & AWARDS: President, Bowman Gray Chapter, Student American Medical Society Student member of Admissions Committee Summer Research Fellowship Upjohn Achievement Award Faculty Award Volunteer of the Year, March of Dimes, Greater Hampton Roads Division, 1996 National Council for Community and Justice, Humanitarian Award, 2000 Life-Time Achievement Award, The Eastern Virginia Medical School Department of Pediatrics, Department of Medical Education Health Care Hero – Inside Business 2012 HOSPITAL/EVMS ACTIVITIES: Director, Neonatal Services, Children’s Hospital of the King’s Daughters, Norfolk, VA NICU Committee, Children’s Hospital of the King’s Daughters, Norfolk, VA Patient Care Committee, Children’s Hospital of the King’s Daughters, Norfolk, VA Utilization Review Committee, Children’s Hospital of the King’s Daughters, Norfolk, VA Mortality Review Committee, Children’s Hospital of the King’s Daughters, Norfolk, VA Chairman, Board of Directors, Pediatric Faculty Associates, Norfolk, VA Co-Chairman, Physician Task Force of the Perinatal Study Group, Eastern Virginia Medical School, Norfolk, VA Board Member, Children’s Health System, Children’s Hospital of the King’s Daughters, Norfolk, VA Professional Affairs Committee – Children’s Hospital of the King’s Daughters, Norfolk, VA Minority Affairs Committee, Eastern Virginia Medical School Student Progress Committee, Eastern Virginia Medical School Continuing Medical Education Committee, Eastern Virginia Medical School 3 COMMUNITY ACTIVITIES: Medical Advisory Committee, March of Dimes, Tidewater Chapter Chairman, Executive Board, March of Dimes, Tidewater Chapter (4/92 - 4/94) State Chairman, Commonwealth of Virginia, March of Dimes (4/94 - 4/98) Board Member, United Jewish Federation of Tidewater Board Member, Tidewater Jewish Foundation of Tidewater, Chairman (2008-2010) Chief Medical Officer- Physicians For Peace Chairman of the Board Physicians For Peace 2010-1012 LICENSURE AND CERTIFICATION: National Board of Medical Examiners, Diplomate 1972 National Board of Medical Examiners, Pediatric Written Examination 1973, Oral Examination 1976 Board Certified, American Board of Pediatrics, June 1976 Board Certified, Neonatal-Perinatal Medicine, American Board of Pediatrics, October 1977 FLEX, June 1977 Virginia State Medical License, 1978 Maryland State Medical License, 2012 PUBLICATIONS: (Abbreviated) 1. Karotkin, E.H, Kido, M, Cashore WJ,.: Acceleration of Fetal Lung Maturation in Pregnant Rabbits; Pediatr. Res. 1976 Aug; 10 (8) 722-4 2. Karotkin, EH, Kido M, Redding R, Cashore WJ, Douglas, W. Stern, L. Oh, W The Inhibition of Pulmonary Maturation in the Fetal Rabbit by Maternal Treatment With Phenobarbital, Am J Obstet Gynecol 1976 Mar 1; 124 (5) 529-31. 3. Karotkin, E.H.: Prevention and Treatment of Neonatal Respiratory Distress Syndrome, Virginia Medical, 106:4, April, 1979. 4 Goldsmith, Jay P., E.H. Karotkin: Assisted Ventilation of the Newborn. W.B. Saunders, 1981 5 Frank, L.M., F.H. Wirth, E.H. Karotkin: Real-Time B-Mode Ultrasonography (Sector Scan) of the Infant Brain. Transactions of the American Neurologic Association, 105:I-3, 1981. 6. Rubio, T., F.H. Wirth, E. Karotkin: Pharmacokinetic Studies of Mezlocillin in Newborn Infants. Journal of Antimicrobial Chemotherapy, Suppl A 9, 1982. 7. Rubio, T., F.H. Wirth, E.H. Karotkin: Pharmacokinetics of Piperacillin in Newborn Infants. Current Chemotherapy and Immunotherapy, I:677-79, 1982. 4 7. Frank, L.M., F.H. Wirth, E.H. Karotkin, J. Schulman, L.C. Earley: Periventricular Leukomalacia: Identification, Incidence, Evolution, and Outcome. Annals of Neurology, 12:2, 1982. 9. Janicke, D.M., T.T. Rubio, F.H. Wirth, E.H. Karotkin, W.J. Jusko: Developmental Pharmacokinetics of Mezlocillin in newborns. Journal of Pediatrics, I04:5, 1984. 10 11 Karotkin, E.H.: Group B Streptococcal Disease in the Newborn. Clinical Update in Pediatrics, 1:2, 1984. Wirth, F., T. Rubio, R. Adelman, J. Schulman, E. Karotkin, M. Solhaug: Comparative Safety Pharmacokinetics and Efficacy Study of Mezlocillin Alone Compared with Ampicillin and Amikacin in the Treatment of Newborn Infants with Suspected or Confirmed Sepsis: First Course of Treatment. Proceedings of the 14th International Congress of Chemotherapy, Kyoto, Japan, June, 1985. 12. Goldsmith, Jay P., E.H. Karotkin: Assisted Ventilation of the Newborn. Second edition. W.B. Saunders, 1988. 13 Goldsmith, Jay P., E.H. Karotkin: Resuscitation of the Neonate. In: Diaz, James H.(ed): Perinatal Anesthesia and Critical Care. W.B. Saunders Company, 1991, pp 209-241. 14. Goldsmith, Jay P., E.H. Karotkin: Assisted Ventilation of the Newborn. Third edition. W.B. Saunders, April, 1996. 15 Goldsmith, Jay P., E.H. Karotkin: Assisted Ventilation of the Newborn. Fourth edition. W. B. Saunders, April 2003. 16.. Goldsmith, Jay P. E.H. Karotkin: Assisted Ventilation of the Newborn. Fifth edition, scheduled for publication 2009. ABSTRACTS AND PRESENTATIONS: 1. Wirth, F.H., T. Rubio, E.H. Karotkin, M.S. Alexander, V. Skansi: Ventriculitis in Newborn Infants with Group B Beta Hemolytic Streptococcal (GBS) Meningitis. Pediatric Research, 13:4, 1979. 2. Karotkin, E.H., Jay P. Goldsmith: The Role of Exchange Transfusion in Neonatal Sepsis. Pediatric Research, 13:4, April, 1979. 3. Wirth, F.H., K. Katz, E.H. Karotkin: The Effect of Physician Attendance on the Quality of Neonatal Transport. Clinical Research, December, 1979 4. Wirth, F.H., T. Rubio, E.H. Karotkin, M.S. Alexander, V. Skansi: Ventriculitis in newborn Infants with Group B Beta Hemolytic Streptococcal Meningitis. Clinical Research, December, 1979. 5 5. Karotkin, E.H., J.P. Goldsmith: The Role of Exchange Transfusion in Neonatal Sepsis. Clinical Research, December, 1979. 6. Frank, L.M., F.H. Wirth, E.H. Karotkin: Real Time B-Mode Ultrasound (Sector Scan) of the Infant Brain. American Neurological Association 105th Annual Meeting, Boston, Massachusetts, September 9, 1980. 7. Rubio, T., F.H. Wirth, E.H. Karotkin: Pharmacokinetics of Piperacillin in Newborn Infants. 12th International Congress of Chemotherapy, Florence, Italy, July 19-24, 1981. 8. Rubio, T., F.H. Wirth, E.H. Karotkin: Pharmacokinetics of Mezlocillin in Newborn Infants. Interscience Conference for Antibiotics and Chemotherapy, Infectious Disease Society, Chicago, Illinois, November, 1981. 9. Frank, L.M., F.H. Wirth, E.H. Karotkin, J. Schulman, L.C. Earley: Periventricular Leukomalacia: Identification, Incidence, Evolution, and Outcome. Child Neurology Society, October 7-9, 1982. 10. Wirth, F., T. Rubio, E. Karotkin: Comparative Studies of Mezlocillin Penicillin/Aminoglycoside Regimes. 9th Annual Congress of Infectious and Paracytic Diseases, Munich, Germany, July 20-26, 1986. 11. “Recent Advances in Neonatal Care,” Virginia Perinatal Association, Roanoke, Virginia, May 6, 1988. 12. “The Jaundiced Neonate,” The fifth EVMS Family Medicine Review Course, Virginia Beach, Virginia, June 6, 1989. 13. “Jaundice in the Newborn” and “New Advances in the Management of RDS in the Neonate,” Southwest Virginia Pediatric Conference, Abingdon, Virginia, August 5-6, 1989. 14. “New Approaches in Neonatal Medicine,” Portsmouth General Hospital, Department of Pediatrics Meeting, October 6, 1989. 15. “Neonatal Drug Addiction,” Tidewater Nursery Nurses Association, Chesapeake, Virginia, October 30, 1989. 16. “Recent Advances in the Treatment of RDS,” American Academy of Pediatrics Annual Meeting, Virginia Chapter, Williamsburg, Virginia, February 23-24, 1990. 17. “Cocaine in Pregnancy,” Department of Mental Health, Mental Retardation, and Substance Abuse Services, Williamsburg, Virginia, June 5, 1990. 18. “Small for Gestational Age vs. Premature--Implications of Differentiation,” The Sixth EVMS Family Medicine Review Course, Virginia Beach, Virginia, June 7, 1990. 6 19. “Surfactant,” Riverside Hospital, Grand Rounds, June 29, 1990. 20. “Neonatal Cocaine Addiction,” Riverside Hospital, Grand Rounds, August 31, 1990. 21. “RDS/Surfactant,” Mary Immaculate Hospital, Grand Rounds, September 28, 1990. 22. “History of RDS,” Naval Regional Medical Center, February 4, 1991. 23. “New Advances in the Treatment of RDS,” Russian Medical Symposium, Moscow, Russia, April 17, 1991. 24. “Recent Advances in the Diagnosis and Treatment of Perinatal Group Beta Strep Infections”, Children’s Hospital of The King’s Daughters – Brickhouse Auditorium, December 11, 1997. 25. “Neonatal Assisted Ventilation”, Sentara Williamsburg Hospital Grand Rounds, September 10, 1997. 26. Lectured at the Second Annual Cuban Pediatric Congress, conducted four lectures October 27-31, 1997: a. “Artificial Surfactant” b. “Recent Advances in the Treatment of Respiratory Failure in Infants. c. “Recent Advances in the Diagnosis and Treatment of Perinatal Group Beta Streptococcal Infections.” d. “Pharmacological Adjuncts to Assisted Ventilation 27. Lectured at the First Annual Tom Hoffheimer Medical Mission Symposium, “Advances in Diagnosis and Treatment of Perinatal Group Beta Strep Infections”, Tel Aviv, Israel, November 1997. 28. Guest Speaker at Chinese Academy of Medicine, Hunan Red Cross Children’s Hospital, March 2000. 29. Guest Speaker at “Handle With Care” Transport Conference, September 12-13, 2001, Norfolk, VA. 30. Guest Speaker at 6th Annual Romanian National Neonatology Association Meeting, Sibiu, Romania, “The Diagnosis and Treatment of Early Neonatal Bacterial Infections,” October 3-5, 2002. 31. Guest Speaker at 20th International Symposium on Neonatal Intensive Care, Venice, Italy, “A Brief History of Neonatal Medicine,” and “Resource Mothers – A Lay Home Visitors Program Which Improves the Outcome of Pregnancy,” November 6-7, 2002. 32. Guest Speaker at International Perinatal Symposium, July 14-18, 2003 Havana, 7 Cuba. 33. Guest Speaker at Update in Neonatal Medicine Meeting, July 21-22, 2003 Havana, Cuba. 34. Guest Speaker at the Seventh Annual Association of Romanian Neonatologists Meeting in Durau, Romania, October 8-12, 2003. 35. Visiting Professor, Montevideo Uruguay, Physicians for Peace Missions, November 2003. 36. Guest Lecturer at Pediatric Society of the Dominican Republic, July 29, 2004. “Recent Advances in the Treatment of Neonatal Respiratory Failure - High Frequency Ventilation and Nitric Oxide.” 37. Guest Lecturer at Indian Pediatric Society Meeting, December 2006, “Neovent 2006”, Nagpur India. 38. Guest Speaker: The Recognition and Treatment of the Infant of the Diabetic Mother, Obstetric Grand Rounds, The Eastern Virginia Medical School, January, 2006 . 39. Guest Speaker at Physician For Peace Celebrating the Nations International Symposium on Maternal and Child Health, “Improving The Outcome of Pregnancy in The Developing World, Virginia Beach, VA, June 2007 40. Guest Lecturer at Indian Pediatric Society Meeting, November 3 and 4, 2007, Agra, India. 41. Medical Mission Leader for Pediatric Nursing, Pediatric Faculty and Resident Education Program, Nagpur India and Swangi Medical Center India. October 30November 8, 2008. 42. Team Leader for Training Program for Neonatal Resuscitation Program and Pediatric Advanced Life Support Program and Maternal and Neonatal Education Symposium, Ahmedabad India, and Jabalpur India, April 13-17, 2009 43. Speaker at Indian Pediatric Society Meeting, Nagpur India “Life Threatening Pediatric Infectious Diseases” November 2010 44. Team leader for Physicians For Peace Medical Mission to Nagpur, Warda and Ahmedabad India: Speaker at Indian Pediatric Society Meeting – “Life Threatening Pediatric Infectious Diseases and Course Director of Neonatal Resuscitation Program: November 2010 45. Team Leader for Physicians For Peace Medical Mission to Kerala, India. Taught Neonatal Resuscitation (Helping Babies Breathe) and provided several lectures to Pediatricians and Neonatologists at Indian Pediatric Society Meeting. November 2011. 8 46. Team Leader for Physicians For Peace Medical Mission to Nagpur, India and presenter of 7 lectures related to improving maternal and child health. Conference entitiled: “From Books to Bedside” Nagpur, Jabalpur, and Sawangi, India, March 815, 2013. GRANTS AND RESEARCH: 1. The use of EXOSURF Pediatric for the prevention or treatment of neonatal respiratory distress syndrome. 2. The use of topical lidocaine ointment to reduce pain during routine circumcision. 3. Perinatal Education and Research Grant. (Virginia State Department of Health, $80,000 - July 1991-June 1992) 4. Steroid regulation of human fetal/neonatal hypothalamic-pituitary-adrenocortical maturation in utero and function postnatally. (Perinatal Research Program, Eastern Virginia Medical School/Children’s Hospital of the King’s Daughters, $43,525 December 1994-November 1996) 5. USAID Grant to establish NICU and Neonatal Education in Moscow, 1990-1995 $1,500,000. 6. Eastern Virginia Medical School/Children’s Hospital of the King’s Daughters, Norfolk-Moscow Partnership Resuscitation Program, Moscow, 1995-1996 $75,000. 7. Virginia Health Care Foundation, Resource Mothers Project, 1997-1999 - $420,000. 8. Healthy Start, Resource Mothers Project, 1998-2001 - $175,000/year for 3 years. 9