A. DALE KAISER, Ph.D.
Professor of Biochemistry and Developmental Biology
Stanford University School of Medicine
Stanford, California 94305-5427
EDUCATION
B.S., Purdue University, West Lafayette, Indiana, Science, 1950
Ph.D., California Institute of Technology, Pasadena, California, Biology and Chemistry 1955
PROFESSIONAL BACKGROUND
1950-52
Graduate Assistant, California Institute of Technology
1952-54
Predoctoral Fellow, National Foundation for Infantile Paralysis
1954-56
Fellow of the American Cancer Society, Service de Physiologie Microbienne, Institute Pasteur,
Paris, France
1956-58
Instructor, Department of Microbiology, Washington University School of Medicine, St. Louis,
Missouri
1958-59
Assistant Professor, Department of Microbiology, Washington University
1959-61
Assistant Professor, Department of Biochemistry, Stanford University, School of Medicine,
Stanford, California
1961-66
Associate Professor of Biochemistry, Stanford University School of Medicine
1966Professor of Biochemistry, Stanford University School of Medicine
1989Professor of Biochemistry and of Developmental Biology, Stanford University School of Medicine
PUBLICATIONS
1. Kaiser, A.D. (1955). A genetic study of the temperate Coliphage . Virology 1:424-443.
2. Kaiser, A.D. (1956). Cooperation de deux Mutants d’un Bacteriophage pour Lysogenisation. Comptes
Rendus Academie des Sciences Francaise 242:3129-3131.
3. Kaiser, A.D. (1957). Mutations in temperate bacteriophage affecting its ability to lysogenize
Escherichia coli. Virology 3:42-61.
4. Kaiser, A.D. and Jacob, F. (1957). Recombination between related temperate phages and genetic
determination of immunity specificity and prophage localization. Virology 4:509-521.
5. Kaiser, A.D. and Hogness, D.S. (1960). The transformation of Escherichia coli with deoxyribonucleic
acid isolated from bacteriophage  dg. J. Mol. Biol. 2:392-415.
6. Josse, J., Kornberg, A. and Kaiser, A.D. (1961). Enzymatic synthesis of deoxyribonucleic acid. VIII.
Frequencies of nearest neighbor base sequences in DNA. J. Biol. Chem. 236:864-875.
7. Kaiser, A.D. (1962). The production of phage chromosome fragments and their capacity for genetic
transfer. J. Mol. Biol. 4:275-287.
8. Kaiser, A.D. and Baldwin, R.L. (1962). A relation between dinucleotide and base frequencies in
bacterial DNAs. J. Mol. Biol. 4:418-419.
A. Dale Kaiser
9. Kaiser, A.D., Tabor, H. and Tabor, C.W. (1963). Spermine protection of coli-phage  DNA against
breakage by hydrodynamic shear. J. Mol. Biol. 6:141-147.
10. Adler, J. and Kaiser, A.D. (1963). Mapping of the galactose genes of Escherichia coli by transduction
with phage P1. Virology 19:117-126.
11. Radding, C.M. and Kaiser, A.D. (1963). Gene transfer by broken molecules of  DNA: activity of the
left half-molecule. J. Mol. Biol. 7:225-233.
12. Bode, V.C. and Kaiser, A.D. (1965). Repression of the CII and CIII cistrons of phage lambda in a
lysogenic bacterium. Virology 25:111-121.
13. Bode, V.C. and Kaiser, A.D. (1965). Changes in the structure and activity of  DNA in a superinfected
immune bacterium. J. Mol. Biol. 14:399-417.
14. Kaiser, A.D. and Inman, R.B. (1965). Cohesion and the biological activity of bacteriophage lambda
DNA. J. Mol. Biol. 13:78-91.
15. Strack, H.B. and Kaiser, A.D. (1965). On the structure of the ends of lambda DNA. J. Mol. Biol.
12:36-49.
16. Kaiser, A.D. (1966). On the internal structure of bacteriophage  lambda. J. Gen. Physiol. 49:171178.
17. Wu, R. and Kaiser, A.D. (1967). Mapping the 5'-terminal nucleotides of the DNA of bacteriophage 
and related phages. Proc. Natl. Acad. Sci. USA 57:170-177.
18. Little, J.W., Lehman, I.R. and Kaiser, A.D. (1967). An exonuclease induced by bacteriophage .
I. Preparation of the crystalline enzyme. J. Biol. Chem. 242:672-678.
19. Liedke-Kulke, M. and Kaiser, A.D. (1967). Genetic control of prophage insertion specificity in
bacteriophages  and 21. Virology 32:465-474.
20. Liedke-Kulke, M. and Kaiser, A.D. (1967). The c-region of Coliphage 21. Virology 32:475-481.
21. Wu, R. and Kaiser, A.D. (1968). Structure and base sequence in the cohesive ends of bacteriophage
lambda DNA. J. Mol. Biol. 35:523-537.
22. Kaiser, A.D. and Wu, R. (1968). Structure and function of DNA cohesive ends. Cold Spring Harbor
on Quant. Biol. 33:729-734.
23. Matsubara, K. and Kaiser, A.D. (1968).  dv: An autonomously replicating DNA fragment. Cold
Spring Harbor on Quant. Biol. 33:769-775.
24. Mackinlay, A.G. and Kaiser, A.D. (1969). DNA replication in head mutants of bacteriophage .
J. Mol. Biol. 39:679-683.
25. Kaiser, A.D. and Masuda, T. (1970). Evidence for a prophage excision gene in . J. Mol. Biol.
47:557-564.
26. Kaiser, A.D. and Masuda, T. (1970). Specificity in curing by heterimmune superinfection. Virology
40:522-529.
27. Casjens, S., Hohn, T. and Kaiser, A.D. (1970). Morphological proteins of phage lambda:
Identification of the major head protein as the product of gene E. Virology 42:496-507.
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A. Dale Kaiser
28. Kaiser, A.D. (1970). Two sequence-specific DNA-protein recognition systems. In: The
Neurosciences (ed., F.O. Schmitt), pp. 955-962.
29. Heinemann, S.F. and Spiegelman, W.G. (1970). Control of transcription of the repressor gene in
bacteriophage lambda. Proc. Natl. Acad. Sci. USA 67:1122-1129.
30. Heinemann, S.F. and Spiegelman, W.G. (1970). Role of gene N product in phage Lambda. Cold
Spring Harbor on Quant. Biol. 35:315-318.
31. Spiegelman, W.G., Heinemann, S.F., Brachet, P., Pereira DaSilva, L and Eisen, H. (1970). Regulation
of the synthesis of phage lambda repressor. Cold Spring Harbor on Quant. Biol. 35:325-330.
32. Reichardt, L. and Kaiser, A.D. (1971). Control of  repressor synthesis. Proc. Natl. Acad. Sci. USA
68:2185-2189.
33. Georgopoulos, C.P. (1971). Bacterial mutants in which the gene N function of bacteriophage lambda is
blocked have an altered RNA polymerase. Proc. Natl. Acad. Sci. USA 68:2977-2981.
34. Kaiser, D. (1971). Lambda DNA Replication. In: The Bacteriophage Lambda (ed. A.D. Hershey),
Cold Spring Harbor Press, New York, Chapter 9, pp. 195-210.
35. Georgopoulos, C.P. (1971). A bacterial mutation affecting N function. In: The Bacteriophage
Lambda (ed. A.D. Hershey), Cold Spring Harbor Press, New York, pp. 639-645.
36. Berg, D.E. (1971). Regulation in phage with duplications of the immunity region. In: The
Bacteriophage Lambda (ed. A.D. Hershey), Cold Spring Harbor Press, New York, pp. 667-678.
37. Casjens, S. (1971). The morphogenesis of the phage lambda head: The step controlled by gene F. In:
The Bacteriophage Lambda (ed. A.D. Hershey), Cold Spring Harbor Press, New York, pp. 725-732.
38. Ordal, G.W. (1971). Supervirulent mutants and the structure of operator and promoter. In: The
Bacteriophage Lambda (ed. A.D. Hershey), Cold Spring Harbor Press, New York, pp. 565-570.
39. Wake, R.G., Kaiser, A.D. and Inman, R.B. (1972). Isolation and structure of phage  head-mutant
DNA. J. Mol. Biol. 64:519-540.
40. Casjens, S., Hohn, T. and Kaiser, A.D. (1972). Head assembly steps controlled by genes F and W in
bacteriophage . J. Mol. Biol. 64:551-563.
41. Spiegelman, W.G., Reichardt, L.F., Yaniv, M., Heinemann, S.F., Kaiser, A.D. and Eisen, H. (1972).
Bidirectional transcription and the regulation of phage  repressor synthesis. Proc. Natl. Acad. Sci.
USA 69:3156-3160.
42. Georgopoulos, C.P., Hendrix, R.W., Kaiser, A.D. and Wood, W.B. (1972). Role of the host cell in
bacteriophage morphogenesis: Effects of a bacterial mutation on T4 head assembly. Nature New
Biology 239:38-41.
43. Brody, T. (1973). A DNA-binding form of the main structure protein of lambda heads. Virology
54:441-451.
44. Georgopoulos, C.P., Hendrix, R.W., Casjens, S.R. and Kaiser, A.D. (1973). Host participation in
bacteriophage lambda head assembly. J. Mol. Biol. 76:45-60.
45. Kaiser, A.D. and Masuda, T. (1973). In vitro assembly of bacteriophage lambda heads. Proc. Natl.
Acad. Sci. USA 70:260-264.
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A. Dale Kaiser
46. Lobhan, P.E. and Kaiser, A.D. (1973). Enzymatic end-to-end joining of DNA molecules. J. Mol. Biol.
78:453-471.
47. Ordal, G.W. and Kaiser, A.D. (1973). Mutations in the right operator of bacteriophage lambda:
Evidence for operator-promoter interpenetration. J. Mol. Biol. 79:709-722.
48. Schedl, P. and Primakoff, P. (1973). Mutants of Escherichia coli Thermosensitive for the synthesis of
transfer RNA. Proc. Natl. Acad. Sci. USA 70:2091-2095.
49. Wang, J.C. and Kaiser, A.D. (1973). Evidence that the cohesive ends of mature  DNA are generated
by the gene A product. Nature New Biology 241:16-17.
50. Hendrix, R. and Casjens, S. (1974). Protein cleavage in bacteriophage  tail assembly. Virology
61:156-159.
51. Syvanen, M. (1974). In vitro genetic recombination of bacteriophage . Proc. Natl. Acad. Sci. USA
71:2496-2499.
52. Syvanen, M. (1974). Recombination of phage  DNA In vitro. In: Mechanisms in Recombination (ed.
R.F. Grell), Plenum Publishing Corporation, New York, pp. 79-88.
53. Hendrix, R. and Casjens, S. (1974). Protein fusion: A novel reaction in bacteriophage  head
assembly. Proc. Natl. Acad. Sci. USA 71:1451-1455.
54. Berg, D.E. (1974). Genetic evidence for two types of gene arrangements in  dv plasmid mutants. J.
Mol. Biol. 86:59-68.
55. Casjens, S.R. and Hendrix, R.W. (1974). Locations and amounts of the major structural proteins in
bacteriophage lambda. J. Mol. Biol. 88:535-545.
56. Hendrix, R.W. and Casjens, S.R. (1974). Protein fusion during the assembly of phage lambda heads.
J. Supramol. Struc. 2:329-336.
57. Casjens, S.R. (1974). Bacteriophage lambda FII gene protein: Role in head assembly. J. Mol. Biol.
90:1-23.
58. Schedl, P., Primakoff, P., and Roberts, J. (1974). Processing of E. coli tRNA precursors. Brookhaven
Symposia in Biology No. 26, pp. 53-76.
59. Kaiser, A.D., Syvanen, M. and Masuda, T. (1974). Processing and assembly of the head of
bacteriophage lambda. J. Supramol. Struc. 2:318-328.
60. Kaiser, D. and Dworkin, M. (1975). Gene transfer to a myxobacterium by Escherichia coli phage P1.
Science 187:653-654.
61. Syvanen, M. (1975). Processing of bacteriophage lambda DNA during its assembly into heads.
J. Mol. Biol. 91:165-174.
62. Kaiser, A.D., Syvanen, M. and Masuda, T. (1975). DNA packaging steps in bacteriophage lambda
head assembly. J. Mol. Biol. 91:175-186.
63. Reichardt, L.F. (1975). Control of bacteriophage lambda repressor synthesis after phage infection:
The role of the N, cII, cIII and cro Products. J. Mol. Biol. 93:267-288.
64. Reichardt, L.F. (1975). Control of bacteriophage lambda repressor synthesis: Regulation of the
maintenance pathway by the cro and cI Products. J. Mol. Biol. 93:289-309.
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65. Hodgkin, J. and Kaiser, D. (1977). Cell-to-cell stimulation of movement in nonmotile mutants of
Myxococcus. Proc. Natl. Acad. Sci. USA 74:2938-2942.
66. Bretscher, A.P. and Kaiser, D. (1978). Nutrition of Myxococcus xanthus, a fruiting Myxobacterium. J.
Bacteriol. 133:763-768.
67. Martin, S., Sodergren, E., Masuda, T. and Kaiser, D. (1978). Systematic isolation of transducing
phages for Myxococcus xanthus. Virology 88:44-53.
68. Kaiser, D. (1978). Genetics of cell interactions in myxobacteria. Birth defects: Original Article
Series, Vol. Xiv, Number 2, pp. 391-399.
69. Hagen, D.C., Bretscher, A.P. and Kaiser, D. (1978). Synergism between morphogenetic mutants of
Myxococcus xanthus. Dev. Biol. 64:284-296.
70. Hodgkin, J. and Kaiser, D. (1979). Genetics of gliding motility in M. xanthus (Myxobacterales):
Genes controlling movement of single cells. Mol. Gen. Genet. 171:167-176.
71. Hodgkin, J. and Kaiser, D. (1979). Genetics of gliding motility in M. xanthus (Myxobacterales): Two
gene systems control movement. Mol. Gen. Genet. 171:177-191.
72. Kaiser, D. (1979). Social gliding is correlated with the presence of pili in Myxococcus xanthus. Proc.
Natl. Acad. Sci. USA 76:5952-5956.
73. Kaiser, D., Manoil, C. and Dworkin, M. (1979). Myxobacteria: Cell interactions, genetics, and
development. Ann. Rev. Microbiol. 33:595-639.
74. Manoil, C. and Kaiser, D. (1980). Accumulation of guanosine tetraphosphate and guanosine
pentaphosphate in Myxococcus xanthus during starvation and myxospore formation. J. Bacteriol.
141:297-304.
75. Manoil, C. and Kaiser, D. (1980). Guanosine pentaphosphate and guanosine tetraphosphate
accumulation and induction of fruiting body development. J. Bacteriol. 141:305-315.
76. Manoil, C. and Kaiser, D. (1980). Purine-containing compounds, including cyclic adenosine 3',5'monophosphate, induce fruiting of Myxococcus xanthus by nutritional imbalance. J. Bacteriol.
141:374–377.
77. Kuner, J. and Kaiser, D. (1981). Introduction of transposon Tn5 into Myxococcus for analysis of
developmental and other non-selectable mutants. Proc. Natl. Acad. Sci. USA 78:425-429.
78. Kuner, J.M., Avery, L., Berg, D.E. and Kaiser, A.D. (1981). Uses of transposon Tn5 in the genetic
analysis of Myxococcus xanthus. In: Microbiology 1981 (ed. D. Schlessinger), ASM Publications, pp.
128-132.
79. Kuner, J. and Kaiser, D. (1982). Fruiting body morphogenesis in submerged cultures of Myxococcus
xanthus. J. Bacteriol. 151:458-461.
80. Shimkets, L. and Kaiser, D. (1982). Induction of coordinated movement of Myxococcus xanthus cells.
J. Bacteriol. 152:451-461.
81. Shimkets, L. and Kaiser, D. (19820. Murein components rescue developmental sporulation of
Myxococcus xanthus. J. Bacteriol. 152:462-470.
82. Shimkets, L. and Kaiser, D. (1982). Developmental cell interactions in Myxococcus xanthus and the
spoC locus. Proc. Natl. Acad. Sci. USA 80:1406-1410.
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A. Dale Kaiser
83. LaRossa, R., Kuner, J., Hagen, D., Manoil, C. and Kaiser, D. (1983). Developmental cell interactions
in Myxococcus analysis of mutants. J. Bacteriol. 153:1394-1404.
84. Sodergren, E. and Kaiser, D. (1983). Insertions of Tn5 near genes that govern stimulatable cell
motility in Myxococcus. J. Mol. Biol. 167:295-310.
85. Sodergren, E., Cheng, Y., Avery, L. and Kaiser, D. (1983). Recombination in the vicinity of insertions
of transposon Tn5 in Myxococcus xanthus. Genetics 105:281-291.
86. Kaiser, D. and Crosby, C. (1983). Cell movement and its coordination in swarms of Myxococcus
xanthus. Cell Motility 3:227-245.
87. Avery, L and Kaiser, D. (1983). In situ transposon replacement and isolation of a spontaneous tandem
genetic duplication. Mol. Gen. Genet. 191:99-109.
88. Avery, L and Kaiser, D. (1983). Construction of tandem genetic duplications with defined endpoints in
Myxococcus xanthus. Mol. Gen. Genet. 191:110-117.
89. Kaiser, D. (1984). Genetics of Myxobacteria. In: Myxobacteria: Development and Cell Interactions,
(ed. E. Rosenberg), Springer, New York, pp. 163-184.
90. Kroos, L. and Kaiser, D. (1984). Construction of Tn5 lac, a transposon that fuses lacZ expression to
exogenous promoters, and its introduction into Myxococcus xanthus. Proc. Natl. Acad. Sci. USA
81:5816-5820.
91. Kaiser, D. (1984). Regulation of multicellular development in myxobacteria. In Microbial
Development (Losick and Shapiro, eds.), Cold Spring Harbor, New York, pp. 197-218.
92. Dworkin, M. and Kaiser, D. (1985). Cell interactions in myxobacterial growth and development.
Science 230:18-24.
93. Kaiser, D., Kroos, L. and Kuspa, A. (1985). Cell interactions govern the temporal pattern of
Myxococcus development. Cold Spring Harbor on Quant. Biol. 50:823-830.
94. Kroos, L., Kuspa, A. and Kaiser, D. (1986). A global analysis of developmentally regulated genes in
Myxococcus xanthus. Dev. Biol. 117:252-266.
95. Kuspa, A, Kroos, L. and Kaiser, D. (1986). Intercellular signaling is required for developmental gene
expression in Myxococcus xanthus. Dev. Biol. 117:267-276.
96. Kaiser, D. (1986). Control of multicellular development: Dictyostelium and Myxococcus. Ann. Rev.
Genet. 20:539-566.
97. Stephens, K. and Kaiser, D. (1987). Genetics of gliding motility in Myxococcus xanthus: Molecular
cloning of the mgl locus. Mol. Gen. Genet. 207:256-266.
98. Kroos, L. and Kaiser, D. (1987). Expression of many developmentally regulated genes in Myxococcus
depends on a sequence of cell interactions. Genes and Devel. 1:840-854.
99. Kroos, L., Hartzell, P., Stephens, K. and Kaiser, D. (1988). A link between cell movement and gene
expression argues that motility is required for cell-cell signaling during fruiting body development.
Genes and Devel. 2:1677-1685.
100. Stephens, K., Hartzell, P. and Kaiser, D. (1989). Gliding motility in Myxococcus xanthus: the mgl
locus, its RNA and predicted protein products. J. Bacteriol. 171:819-830.
101. Kaiser, D. 1989). Multicellular development in myxobacteria. In Genetics of bacterial diversity, (D.A.
Hopwood and K.F. Chater, eds.), Harcourt Brace, London, pp. 243-263.
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A. Dale Kaiser
102. Kuspa, A and Kaiser, D. (1989). Genes required for developmental signalling in Myxococcus xanthus:
three asg loci. J. Bacteriol. 171:2762-2772.
103. Cheng, Y. and Kaiser, D. (1989). dsg, a gene required for a cell-cell interaction early in Myxococcus
development. J. Bacteriol. 171:3719-3726.
104. Cheng, Y. and Kaiser, D. (1989). dsg, a gene required for Myxococcus xanthus development is
necessary for cell viability. J. Bacteriol. 171:3727-3731.
105. Mayo, K. and Kaiser, D. (1989). asgB, a gene required for developmental signaling, aggregation, and
sporulation of Myxococcus xanthus. Mol. Gen. Genet. 218:409-418.
106. Kuspa, A, Vollrath, D., Cheng, Y. and Kaiser, D. (1989). Physical mapping of the Myxococcus
xanthus genome by random cloning in yeast artificial chromosomes. Proc. Natl. Acad. Sci. USA
86:8917-8921.
107. Kroos, L., Kuspa, A. and Kaiser, D. (1990). Defects in fruiting body development caused by Tn5 lac
insertions in Myxococcus xanthus. J. Bacteriol. 172:484-487.
108. Kim, S.K. and Kaiser, D. (1990). C-factor: A cell-cell signaling protein required for fruiting body
morphogenesis of M. xanthus. Cell 61:19-26.
109. Kim, S.K. and Kaiser, D. (1990). Cell motility is required for the transmission of C-factor, an
intercellular signal that coordinates fruiting body morphogenesis of Myxococcus xanthus. Genes and
Devel. 4:896-905.
110. Kim, S.K. and Kaiser, D. (1990). Purification and properties of Myxococcus xanthus C-factor, an
intercellular signaling protein. Proc. Natl. Acad. Sci. USA 87:3635-3639.
111. Kim, S.K. and Kaiser, D. (1990). Cell alignment required in differentiation of Myxococcus xanthus.
Science 249:926-928.
112. Kaiser, D. (1991). Genetic systems in myxobacteria. Methods in Enzymology 204:357-372.
113. Kaplan, H.B., Kuspa, A. and Kaiser, D. (1991). Suppressors that permit A signal-independent
developmental gene expression in Myxococcus xanthus. J. Bacteriol. 173:1460-1470.
114. Kim, S.K. and Kaiser, D. (1991). C-factor has distinct aggregation and sporulation thresholds during
Myxococcus development. J. Bacteriol. 173:1722-1728.
115. Kimsey, H.H. and Kaiser, D. (1991). Targeted disruption of the Myxococcus xanthus orotidine 5'monophosphate decarboxylase gene: effects on growth and fruiting-body development. J. Bacteriol.
173:6790-6797.
116. Hartzell, P. and Kaiser, D. (1991). Function of MglA, a 22-kilodalton protein essential for gliding in
Myxococcus xanthus. J. Bacteriol. 173:7615-7624.
117. Hartzell, P. and Kaiser, D. (1991). Upstream gene of the mgl operon controls the level of MglA
protein in Myxococcus xanthus. J. Bacteriol. 173:7625-7635.
118. Kim, S.K. (1991). Intercellular signaling in Myxococcus development: the role of C factor. Trends in
Genetics 7:361-365.
119. Kimsey, H., Kaiser, D. (1992). The Orotidine 5'-Monophosphate Decarboxylase Gene of Myxococcus
xanthus. J. Biol. Chem. 267:819-824.
120. Plamann, L., Kuspa, A. and Kaiser, D. (1992). Proteins that rescue A-signal-defective mutants of
Myxococcus xanthus. J. Bacteriol. 174:3311-3318.
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A. Dale Kaiser
121. Kuspa, A., Plamann, L. and Kaiser, D. (1992). Identification of heat-stable A-factor from Myxococcus
xanthus. J. Bacteriol. 174:3319-3326.
122. Kuspa, A. Plamann, L. and Kaiser, D. (1992). A-signalling and the cell density requirement for
Myxococcus xanthus development. J. Bacteriol. 174:7360-7369.
123. Kim, S.K., Kaiser, D. and Kuspa, A. (1992). Control of cell density and pattern by intercellular
signaling in Myxococcus development. Ann. Rev. Microbiol. 46:117-139.
124. Sager, B. and Kaiser, D. (1993). Two cell-density domains within the Myxococcus xanthus fruiting
body. Proc. Natl. Acad. Sci. USA 90:3690-3694.
125. Kaiser, D. and Losick, R. (1993). How and why bacteria talk to each other. Cell 73:873-885.
126. Sager, B. and Kaiser, D. (1993). Spatial restriction of cellular differentiation. Genes and Devel.
7:1645-1653.
127. Kaiser, D. (1993). Roland Thaxter’s legacy and the origins of multicellular development. Genetics
135:249-254.
128. Russo-Marie, F., Roederer, M., Sager, B., Herzenberg, L.A. and Kaiser, D. (1993). -galactosidase
activity in single differentiating bacterial cells. Proc. Natl. Acad. Sci. USA 90:8194-8198.
129. Thöny-Meyer, L. and Kaiser, D. (1993). devRS, an autoregulated and essential genetic locus for
fruiting body development in Myxococcus xanthus. J. Bacteriol. 175:7450-7462.
130. Cheng, Y.L., Kalman, L.V. and Kaiser, D. (1993). The dsg gene of Myxococcus xanthus. J. Bacteriol.
176:1427-1433.
131. Kalman, L.V., Cheng, Y.L. and Kaiser, D. (1994). The Myxococcus xanthus dsg gene product
performs functions of translation initiation factor IF3 in vivo. J. Bacteriol. 176:1434-1442.
132. He, Q., Chen, H., Kuspa, A., Cheng, Y., Kaiser, D. and Shimkets, L. (1994). A physical map of the
Myxococcus xanthus chromosome. Proc. Natl. Acad. Sci. USA 91:9584-9587.
133. Sager, B. and Kaiser, D. (1994). Intercellular C-signalling and the traveling waves of Myxococcus.
Genes and Devel. 8:2793-2804.
134. Singer, M. and Kaiser, D. (1995). Ectopic production of guanosine penta-and tetraphosphate can
initiate early developmental gene expression in Myxococcus xanthus. Genes and Devel. 9:1633-1644.
135. Keseler, I. and Kaiser, D. (1995). An early A-signal-dependent gene in Myxococcus xanthus has a 54like promoter. J. Bacteriol. 177:4638-4644.
136. Spormann, A.M. and Kaiser, D. (1995). Gliding movements in Myxococcus xanthus. J. Bacteriol.
177:5846-5852.
137. Wu, S. and Kaiser, D. (1995). Genetic and functional evidence that Type IV pili are required for social
gliding motility in Myxococcus xanthus. Mol. Microbiol. 18:547-558.
138. Søgaard-Andersen, L. and Kaiser, D. (1996). C-factor, a cell surface-associated intercellular signaling
protein, stimulates the cytoplasmic Frz signal transduction system in Myxococcus xanthus. Proc. Natl.
Acad. Sci. USA 93:2675-2679.
139. Søgaard-Andersen, L., Slack, F.J., Kimsey, H. and Kaiser, D. (1996). Intercellular C-signaling in
Myxococcus xanthus involves a branched signal transduction pathway. Genes and Devel. 10:740-754.
140. Kaiser, D. (1996). Bacteria also vote. Science 272:1598-1599.
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A. Dale Kaiser
141. Wu, S.S. and Kaiser, D. (1996). Markerless deletions of pil genes in Myxococcus xanthus generated by
counterselection with the Bacillus subtilis sacB gene. J. Bacteriol. 178:5817-5821.
142. Wu, S.S. and Kaiser, D. (1997). The Myxococcus xanthus pilT locus is required for social gliding
motility although pili are still produced. Mol. Microbiol. 23:109-121.
143. Keseler, I.M. and Kaiser, D. (1997). 54, a vital protein for Myxococcus xanthus. Proc. Natl. Acad.
Sci. USA 94:1979-1984.
144. Rodriguez-Soto, J.P. and Kaiser, D. (1997). The tgl gene: Social motility and stimulation in
Myxococcus xanthus. J. Bacteriol. 179:4361-4371.
145. Rodriguez-Soto, J.P. and Kaiser, D. (1997). Identification and localization of the Tgl protein, which is
required for Myxococcus xanthus social motility. J. Bacteriol. 179:4372-4381.
146. Wu, S.S. and Kaiser, D. (1997). Regulation of expression of the pilA gene in Myxococcus xanthus. J.
Bacteriol. 179:7748-7758.
147. Wu, S.S., Wu, J., Cheng, Y.L. and Kaiser, D. (1998). The pilH gene encodes an ABC transporter
homologue required for type IV pilous biogenesis and social gliding motility in Myxococcus xanthus.
Mol. Microbiol. 29:1249-1261.
148. Wall, D., Wu, S.S. and Kaiser, D. (1998). Contact stimulation of Tgl and type IV pili in Myxococcus
xanthus. J. Bacteriol. 180:759-761.
149. Wall, D. and Kaiser, D. (1998). Alignment enhances the cell-to-cell transfer of pilus phenotype. Proc.
Natl. Acad. Sci. USA 95:3054-3058.
150. Gorski, L. and Kaiser, D. (1998). Targeted mutagenesis of sigma-54 activator proteins in Myxococcus
xanthus. J. Bacteriol. 180:5896-5905.
151. Harris, B.Z., Kaiser, D. and Singer, M. (1998). The guanosine nucleotide (p)ppGpp initiates
development and A-factor production in Myxococcus xanthus. Genes and Devel. 12:1022-1035.
152. Wall, D., Kolenbrander, P.E. and Kaiser, D. (1999). The Myxococcus xanthus pilQ (sglA) gene
encodes a secretin homolog required for Type IV pilus biogenesis, social motility, and development. J.
Bacteriol. 181:24-33.
153. Spormann, A.M. and Kaiser, D. (1999). Gliding mutants of Myxococcus xanthus with high reversal
frequencies and small displacements. J. Bacteriol. 181:2593-2601.
154. Wall, D. and Kaiser, D. (1999). Type IV pili and cell motility. Mol. Microbiol. 32:1-10.
155. Kaiser, D. (1999). Cell fate and organogenesis in bacteria. Trends Genet. 15:273-277.
156. Fontes, M. and Kaiser, D. (1999). Myxococcus cells respond to elastic forces in their substrate. Proc.
Natl. Acad. Sci. USA 96:8052-8057.
157. Gorski, L., Gronewold, T. and Kaiser, D. (2000). A 54 activator protein necessary for spore
differentiation within the fruiting body of Myxococcus xanthus. J. Bacteriol. 182:2438-2444.
158. Licking, E., Gorski, L. and Kaiser, D. (2000). A common step for changing cell shape in fruiting body
and starvation-independent sporulation of Myxococcus xanthus. J. Bacteriol. 182:3553-3558.
159. Julien, B., Kaiser, D. and Garza, A. (2000). Spatial control of cell differentiation in Myxococcus
xanthus. Proc. Natl. Acad. Sci. USA 97:9098-9103.
160. Kaiser, D. (2000). Bacterial motility: how do pili pull? Curr. Biol. 10:777-780.
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161. Kronstad, J.W. and Kaiser, D. (2001). Growth and development: signals and their transduction. Curr.
Opin. Microbiol. 3:3553-3558.
162. Gronewold, T.M. and Kaiser, D. (2001). The act operon controls the level and time of C-signal
production for M. xanthus development. Mol. Microbiol. 40:744-756.
163. Karlin, S., Mrázek, J., Campbell, A. and Kaiser, D. (2001). Characterizations of highly expressed
genes of four fast-growing bacteria. J. Bacteriol. 183:5025-5040.
164. Kaiser D. (2001). Building a multicellular organism. Annu. Rev. Genet. 35:103-123.
165. Welch, R. and Kaiser, D. (2001). Cell behavior in traveling wave patterns of myxobacteria. Proc.
Natl. Acad. Sci. USA 98:14907-14912.
166. Igoshin, O.A., Mogilner, A., Welch, R.D., Kaiser, D. and Oster, G. (2001). Pattern formation and
traveling waves in myxobacteria: theory and modeling. Proc. Natl. Acad. Sci. USA 98:14913-14918.
167. Gronewold, T.M. and Kaiser, D. (2002) act operon control of developmental gene expression in
Myxococcus xanthus. J. Bacteriol. 184:1172-1179.
168. Wolgemuth, C., Hoiczyk, E., Kaiser, D. and Oster, G. (2002). How myxobacteria glide. Curr. Biol.
12:1-20.
169. Kaiser D. (2003). Coupling cell movement to multicellular development in myxobacteria. Nat. Rev.
Microbiol. 1:45-54. Review.
170. Kaiser, D. and Welch, R. (2004). Dynamics of fruiting body morphogenesis. J. Bacteriol. 186:919927.
171. Jakobsen, J.S., Jelsbak, L., Jelsbak, L., Welch, R.D., Cummings, C., Goldman, B., Stark, E., Slater, S.,
Kaiser, D. (2004). 54 Enhancer binding proteins and Myxococcus xanthus fruiting body development.
J. Bacteriol. 186:4361-4368.
172. Igoshin, O.A., Welch, R., Kaiser, D. and Oster, G. (2004). Waves and aggregation patterns in
myxobacteria. Proc. Natl. Acad. Sci. USA 101:4256-4261.
173. Nudleman, E. and Kaiser, D. (2004). Pulling together with type IV pili. J. Mol. Microbiol Biotechnol.
7:52-62. Review.
174. Igoshin, O., Kaiser, D. and Oster, G. (2004). Primer: Breaking symmetry in myxobacteria. Curr.
Biol.14:R1-R4.
175. Igoshin, O., Goldbetter, A, Kaiser, D. and Oster, G. (2004). A biochemical oscillator explains the
developmental progression of myxobacteria. Proc. Natl. Acad. Sci. USA 101:15760-15765.
176. Igoshin, O., Welch, R., Kaiser, D. and Oster, G. (2004). Waves and aggregation patterns in
myxobacteria. Proc. Natl. Acad. Sci. USA 101:4256-4261.
177. Kaiser, D. (2004). Signaling in myxobacteria. Annu. Rev. Microbiol. 58:75-98. Review.
178. Jelsbak, L. and Kaiser, D. (2005). Regulating pilin expression reveals a threshold for S motility in
Myxococcus xanthus. J. Bacteriol. 187:2105-2112.
179. Jelsbak, L., Givskov, M. and Kaiser, D. (2005). Enhancer-binding proteins with a forkhead-associated
domain and the 54 regulon in Myxococcus xanthus fruiting body development. Proc. Natl. Acad. Sci.
USA. 102:3010-3015.
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180. Kaiser, D. and Yu, R. (2005). Reversing cell polarity: evidence and hypothesis. Curr. Opin.
Microbiol. 8:216-221. Review.
181. Nudleman, E., Wall, D. and Kaiser, D. (2005). Cell-to-cell transfer of bacterial outer membrane
lipoproteins. Science 309:125-127.
182. Sozinova, O., Jang, Y., Kaiser, D. and Alber, M.S. (2005). Three-dimensional model of
myxobacterial aggregation by contact-mediated interaction. Proc. Natl. Acad. Sci. USA 102:1130811312.
183. Nudleman, E., Wall, D. and Kaiser, D. (2006). Polar assembly of the type IV pilus secretin in
Myxococcus xanthus. Mol. Microbiol. 60:16-29.
184. Sozinova, O., Jang, Y., Kaiser, D. and Alber, M. (2006). A Three-Dimensional Model of
Myxobacterial Fruiting Body Formation. Proc. Natl. Acad. Sci. USA 103:17255-17259.
185. Goldman, B.S., Nierman, W.C., Kaiser, D., Slater, S.C., Durkin, A.S., Eisen, J.A., Ronning, C.M.,
Barbazuk, W.B., Blanchard, M., Field, C., Halling, c. Hionkle, G., Iartchuk, O., Kim, H.S., Mackenzie,
C., Madupu, R., Miller, N., Shvartsbeyn, A., Sullivan, S.A., Vaudin, M., Wiegand, R. and Kaplan,
H.B. (2006). Evollution of sensory complexity recorded in a myxobacterial genome. Proc. Natl. Acad.
Sci. USA 103:15200-15205.
186. Kaiser, D. (2006). A microbial genetic journey. Annu. Rev. Microbiol. 60:1-25. Review.
187. Karlin, S., Brocchieri, L., Mrázek, J. and Kaiser, D. (2006). Distinguishing features of deltaproteobacterial genomes. Proc. Natl. Acad. Sci. USA 103:11352-11357.
188. Yu, R. and Kaiser, D. (2007). Gliding motility and polarized slime secretion. Mol. Microbiol. 63:454467.
189. Kaiser, D. (2007). Bacterial swarming: a re-examination of cell-movement patterns. Curr. Biol.
17:R561-R570. Review.
190. Wu, Y., Jiang, Y., Kaiser, D. and Alber, M. (2007). Social interactions in myxobacterial swarming.
PLoS Computational Biology 10.1371.
191. Gronewold, T.M. and Kaiser, D. (2007). Mutations of the act promoter in Myxococcus xanthus.
J. Bacteriol. 189:1836-1844.
192. Kaiser, D. (2008). Reversing Myxococcus polarity, in Myxobacteria, multicellularity and
differentiation, (ed. Whitworth, D.E.), ASM Press, Washington, DC, pp. 93-102.
193. Kaiser, D. (2008). Myxococcus-From Single-Cell Polarity to Complex Multicellular Patterns. Annu.
Rev. Genet. 42:109-130.
194. Kaiser, D. (2008) C-signal control of aggregation and sporulation, in Chemical communication among
bacteria. (ed. Bassler, B. L. and Winans, S. C.) ASM Press, Washington, DC. pp. 51- 63.
195. Wu, Y., Kaiser, D., Jiang, Y., and Alber, M., (2009), Periodic reversal of direction
allows myxobacteria to swarm. Proc Natl Acad Sci USA 106:1222-1227.
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196. Kaiser, D., (2009) Are there lateral as well as polar engines for A-motile gliding in myxobacteria. J.
Bacteriol. 191, 5336-5341.
197. Kaiser, D., Warrick, H. (2011) Swarming and multicellular morphogenesis in myxobacteria.
Submitted for publication to J. Bacteriology.
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