Juan Du
Juan.du.3@asu.edu
EDUCATION
Ph. D. Medical Immunology June 2008
Medical School,Shandong University, China.
Dissertation: HBV core protein downregulated TRAIL-induced apoptosis through
decreasing DR5 expression. (a successive postgraduate and doctoral program)
Advisor: Dr. Wensheng Sun (Director of institute of Immunology)
B.S
Clinical Medicine June 2003
Xinxiang Medical College, China
PROFESSIONAL EXPERIENCE
2003– 2008 Graduate Research
Institute of Immunology, School of Medicine, Shandong University, China
 Pursued research to clarify the different effects of HBV encoding proteins on TRAILinduces apoptosis and our findings may help clarify the roles of imbalanced apoptosis in the
pathogenesis of hepatitis B infection. This project was funded by NSFC and was executed in
collaboration with Youhai Chen (University of Pennsylvania).
 Identified the effects of HBc protein on TRAIL-induced apoptosis.
 Designed and constructed pGAPZa-sTRAIL Vector to express and purify TRAIL protein
in picha yeast.
 Analyzed samples using correlative Confocal microscope and TUNEL, qPCR, FCS,
IHC ,Western blot ,Cell-based assays and mouse models.
 Teaching Assistant: Lectured experimental class (~45 undergrad, 2 hours class every week)
2008 – present Research Staff and Scientific Facility Supervisor
Central Lab of Qianfo Shan Hospital, Jinan, China
 Worked in a 14 staff member Center of Shandong Qianfo Shan hospital, and managed all
of the instrument( microscopy, qPCR instrument et al.) and developed new application.
 Explored the mechanism of HBc protein modulating microRNA .
2013 – 2014
Visiting Scholar
Center for Personalized Diagonostics ,Biodesign Institute, Arizona State University,USA
JOURNAL PUBLICATIONS
 Juan Du, Xiaohong Liang, Yugang Liu, et al. Hepatitis B virus core protein inhibits
TRAIL -induced apoptosis of hepatocytes by blocking DR5 expression. Cell Death Differ
2009 Feb.（SCI， IF=8.2）
 Juan Du, Lei Wang, Jianjun Han, Lifen Gao, Chunhong Ma, Xiaohong Liang. Serum
soluble death receptor 5 concentration in patients with chronic hepatitis B is associated with
liver damage and viral antigen level. Clin Biochem. 2012 Jul;45(10-11):845-7. Epub 2012
Apr 17. （SCI， IF=2.2）
 Xiaohong Liang, Juan Du （Co-auther）, Yugang Liu, et al.The hepatitis B virus
protein MHBs(t) sensitizes hepatoma cells to TRAIL- induced apoptosis through ERK2.
Apoptosis 2007 Oct.（SCI， IF=3.421）
 Xiaohong Liang, Zhonghua Qua, Zhiyong Zhang, Juan Du, et al. Blockade of preS2
down-regulates the apoptosis of HepG2.2.15 cells induced by TRAIL. Biochem BiophysRes
Commun. 2008 May 2;369(2):456-63（SCI，IF=2.855）
 Lili Cao，Lihui Han，Zhiyong Zhang，Jie Li，Zhonghua Qu，Juan Du， et al.
Involvement of anoikis-resistance in the metastasis of hepatoma cells. Experimental Cell
Research[Epub ahead of print] (SCI，IF=3.695)
 Zhiyong Zhang，Lili Cao，Jie Li， Xiaohong Liang， Yugang Liu， Hua Liu， Juan
Du，et al. Acquisition of anoikis resistance reveals a synoikis-like survival style in
BEL7402hepatoma cells. Cancer Letters. 267 (2008) 106–115 （SCI，IF=3.398）.
 Zhiyong Zhang，Lihui Han，Lili Cao，Xiaohong Liang, Yugang Liu, Hua Liu, Juan
Du,et al. Aggregation formation mediated anoikis resistance of BEL7402 hepatoma cells.
Folia Histochem Cytobiol. 2008;46(3):331-6（SCI，IF=0.886.）
 Yu-Gang Liu, Su-Xia Liu, Xiao-Hong Liang, Qiu Zhang, Li-Fen Gao, Li-Hui Han, YingLin Cao Nan Hou, Juan Du, et al. Blockade of TRAIL pathway ameliorates HBV-induced
hepatocyte apoptosis in an acute hepatitis model. Biochem Biophys Res Comm. 2007 Jan
12;352(2):329-34（SCI，IF=2.855）
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EDITED BOOK
“Cell and molecular biology ” edited by Juan Du (2012), Press of Jilin University, China.
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HONORS and AWARDS
2007.08 Outstanding postgraduate of Shandong University.
2007.08 Science acheivement scholarship of Shandong University.
2009.02 The 19th APASL Conference Oral presentation and Travel award.
2009.07 The 5th Ditan International Conference AGD shortlisted prize.
2009.06 Outstanding doctor’s dissertation of Shandong province .
2009.11 Outstanding Doctor’s Dissertation of Shandong University .
2011.05 Outstanding young and middle-aged Researcher of Qianfoshan Hospital.