CURRICULUM VITAE IOANNIS (JOHN) T. PARISSIS, MD, FESC PERSONAL DETAILS Surname: Parissis Forename: Ioannis (John) Date of Birth: 4 June 1965 Gender: Male Nationality: Greek Address: Navarinou 13, 15122 Maroussi, Athens, Greece Day Telephone: +30 6944322627 Home Telephone: +30 210 6123720 Email: jparissis@yahoo.com MEDICAL EDUCATION 1990 Medical Diploma: University of Patras, Greece Class of Degree: Excellent 1999 PhD, National University of Crete Medical School DEGREES AND QUALIFICATIONS Medical Specialty: Cardiology 1998, Prefecture of East Attica, Directorate of Health and Welfare, Greece Consultant Cardiologist: 2000-2004, Heart Failure Clinic, Amalia Fleming Hospital, Athens, Greece 1 Lecturer, Cardiology: 2005-2009, Heart failure Unit, University of Athens, Greece Assistant Professor, Cardiology: 2010-2013, Heart failure Unit and Second Department of Cardiology, University of Athens, Greece. Honorary Consultant, Heart Failure/ Heart Transplant: 1/1/2011-6/6/2011, Royal Brompton and Herfield NHS Trust Hospitals, London, UK. CLINICAL AND RESEARCH EXPERIENCE Member of faculty of Cardiology Department and Heart Failure Unit, Attikon University General Hospital, Athens, Greece. Clinical and research interests include: Clinical cardiology- Heart Failure - comorbidities (anemia, depression, diabetes, COPD, obesity) in chronic and acute heart failure, - new cardiac enhancers and vasodilators in acute heart failure syndromes and advanced heart failure (levosimendan, etc), - biomarkers in heart failure - management of acute and advanced heart failure Author or co-author in many publications in peer-reviewed international journals (see list of publications), numerous cardiology book chapters, and over 200 abstracts in important scientific meetings, including the American Heart Association Scientific Sessions, the American College of Cardiology Scientific Meetings, the Annual Congress of the European 2 Society of Cardiology (ESC) and the Annual Congress of the Heart Failure Association of the ESC. Reviewer in several international journals (see relevant list). Abstract Grader for the: a) ESC annual main congress, b) Heart Failure Association of ESC annual congress, and c) Acute Cardiac Care association of ESC annual congress. Speaker and/or Chairman in round tables or clinical seminars in a) ESC annual main congress, b) Heart Failure Association of ESC annual congress, and c) Acute Cardiac Care association of ESC annual congress. Active member of many professional organizations: Chairman of the Hellenic Working Group on Heart Failure (2007-2008); Fellow of the ESC and a member of the ESC Heart Failure and Acute Cardiac Care Associations. Participant in clinical trials in heart failure: BEATIFUL, EMPHASIS, HORIZON-HF, REACH-UP, ATOMIC-HF, BIOSTAT, BACH. Member of steering committee of ALARM-HF survey that examined the clinical profile and management of acute heart failure syndromes in Europe, Latin America and Australia. Co-Principal Investigator of LEVOREP trial that investigates the role of pulsed infusions of Levosimendan on advanced heart failure. National coordinator for Greece and member of international steering committee of the ESC Pilot Registry on acute and chronic heart failure. Member of ESC Heart Failure Association committee which co-ordinates European national working groups or societies on heart failure. Member of Task Force for Curriculum Heart Failure of ESC Heart Failure Association. 3 Reviewer of ESC guidelines for Heart Failure 2012. Teaching: 1) Responsible for lectures on Heart Failure for undergraduate medical students (5th grade), Athens University Medical School, Second Department of Cardiology. Responsible for clinical training of undergraduate medical students (hands on experience). 2) Member of committee and/or supervisor of many PhDs on Heart Failure of Athens University Medical School, Second Department of Cardiology. 3) Member of committee and/or supervisor of many post-graduating programs for nurses, Athens University, Second Department of Cardiology. Publications in international per-review journals: Citations-Scopus: 2483; h-index: 27 Total Impact Factor : 549,695 ; Mean Impact factor: 4,133 First Author : 46 publications, Second Author : 38, Last Author : 5 Cardiology : 1. Parissis JT, Papadakis J, Kadoglou NP, Varounis C, Psarogiannakopoulos P, RafouliStergiou P, Ikonomidis I, Paraskevaidis I, Dimopoulou I, Zerva A, Dima K, Anastasiou-Nana M, Filippatos G. Prognostic value of high sensitivity troponin T in patients with acutely decompensated heart failure and non-detectable conventional troponin T levels. Int J Cardiol. 2013 May 24. doi:pii: S0167-5273(13)00965-0. 10.1016/j.ijcard.2013.05.056. [Epub ahead of print]. 4 2. Parissis JT, Farmakis D, Fountoulaki K, Rigas A, Nikolaou M, Paraskevaidis IA, Bistola V, Venetsanou K, Ikonomidis I, Anastasiou-Nana M, Kremastinos DT, Filippatos G. Clinical and neurohormonal correlates and prognostic value of serum prolactin levels in patients with chronic heart failure. Eur J Heart Fail. 2013 May 2. [Epub ahead of print]. 3. Maggioni AP, Dahlström U, Filippatos G, Chioncel O, Leiro MC, Drozdz J, Fruhwald F, Gullestad L, Logeart D, Fabbri G, Urso R, Metra M, Parissis J, Persson H, Ponikowski P, Rauchhaus M, Voors AA, Nielsen OW, Zannad F, Tavazzi L; on behalf of the Heart Failure Association of the European Society of Cardiology (HFA). EURObservational Research Programme: regional differences and 1-year follow-up results of the Heart Failure Pilot Survey (ESC-HF Pilot). Eur J Heart Fail. 2013 Mar 28. [Epub ahead of print] 4. Nikolaou M, Parissis J, Yilmaz MB, Seronde MF, Kivikko M, Laribi S, Paugam-Burtz C, Cai D, Pohjanjousi P, Laterre PF, Deye N, Poder P, Solal AC, Mebazaa A. Liver function abnormalities, clinical profile, and outcome in acute decompensated heart failure. Eur Heart J. 2012 Oct 22. [Epub ahead of print] 5. Rafouli-Stergiou P, Parissis JT, Anastasiou-Nana M. Inotropes for the management of acute heart failure patients with renal dysfunction. Still an option? Expert Opin Pharmacother. 2012 Dec;13(18):2637-47. 6. Parissis JT, Mantziari L, Kaldoglou N, Ikonomidis I, Nikolaou M, Mebazaa A, Altenberger J, Delgado J, Vilas-Boas F, Paraskevaidis I, Anastasiou-Nana M, Follath F. Gender-related differences in patients with acute heart failure: Management and predictors of in-hospital mortality. Int J Cardiol. 2012 Oct 4. doi:pii: S0167-5273(12)01202-8. 7. Kourouklis SP, Vagiakis E, Paraskevaidis IA, Farmakis D, Kostikas K, Parissis JT, Katsivas A, Kremastinos DT, Anastasiou-Nana M, Filippatos G. Effective sleep apnoea 5 treatment improves cardiac function in patients with chronic heart failure. Int J Cardiol. 2012 Oct 2. doi:pii: S0167-5273(12)01207-7. 8. Pappas C, Ntai K, Parissis JT, Anastasiou-Nana M. Dual anti-platelet therapy in patients with G6PD deficiency after percutaneous coronary intervention. Int J Cardiol. 2012 Sep 11. doi:pii: S0167-5273(12)01053-4. 9. McMurray JJ, Adamopoulos S, Anker SD, Auricchio A, Böhm M, Dickstein K, Falk V, Filippatos G, Fonseca C, Gomez-Sanchez MA, Jaarsma T, Køber L, Lip GY, Maggioni AP, Parkhomenko A, Pieske BM, Popescu BA, Rønnevik PK, Rutten FH, Schwitter J, Seferovic P, Stepinska J, Trindade PT, Voors AA, Zannad F, Zeiher A; Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology, Bax JJ, Baumgartner H, Ceconi C, Dean V, Deaton C, Fagard R, Funck-Brentano C, Hasdai D, Hoes A, Kirchhof P, Knuuti J, Kolh P, McDonagh T, Moulin C, Popescu BA, Reiner Z, Sechtem U, Sirnes PA, Tendera M, Torbicki A, Vahanian A, Windecker S, McDonagh T, Sechtem U, Bonet LA, Avraamides P, Ben Lamin HA, Brignole M, Coca A, Cowburn P, Dargie H, Elliott P, Flachskampf FA, Guida GF, Hardman S, Iung B, Merkely B, Mueller C, Nanas JN, Nielsen OW, Orn S, Parissis JT, Ponikowski P; ESC Committee for Practice Guidelines. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur J Heart Fail. 2012 Aug;14(8):803-69. 10. Paraskevaidis IA, Iliodromitis EK, Ikonomidis I, Rallidis L, Hamodraka E, Parissis J, Andoniadis A, Tzortzis S, Anastasiou-Nana M. The effect of acute administration of statins on coronary microcirculation during the pre-revascularization period in patients with myocardial infraction. Atherosclerosis. 2012 Jul;223(1):184-9 6 11. Ikonomidis I, Michalakeas CA, Parissis J, Paraskevaidis I, Ntai K, Papadakis I, Anastasiou-Nana M, Lekakis J. Inflammatory markers in coronary artery disease. Biofactors.2012 Sep-Oct;38(5):320-8. 12. Fountoulaki K, Parissis J. Hepatocyte Growth Factor as a Prognostic Marker in Heart Failure: Promise and Challenges. Cardiology. 2012 May 3;121(4):237-239. 13. Ikonomidis I, Tzortzis S, Paraskevaidis I, Triantafyllidi H, Papadopoulos C, Papadakis I, Trivilou P, Parissis J, Anastasiou-Nana M, Lekakis J. Association of abnormal coronary microcirculatory function with impaired response of longitudinal left ventricular function during adenosine stress echocardiography in untreated hypertensive patients. Eur Heart J Cardiovasc Imaging. 2012 Dec;13(12):1030-40. 14. Paraskevaidis I, Palios J, Parissis J, Filippatos G, Anastasiou-Nana M. Treating depression in coronary artery disease and chronic heart failure: what's new in using selective serotonin re-uptake inhibitors? Cardiovasc Hematol Agents Med Chem. 2012 Jun;10(2):10915. 15. Steinacher R, Parissis JT, Strohmer B, Eichinger J, Rottlaender D, Hoppe UC, Altenberger J. Comparison between ATS/ERS age- and gender-adjusted criteria and GOLD criteria for the detection of irreversible airway obstruction in chronic heart failure. Clin Res Cardiol. 2012 Aug;101(8):637-45. 16. Parissis JT, Rafouli-Stergiou P, Mebazaa A, Ikonomidis I, Bistola V, Nikolaou M, Meas T, Delgado J, Vilas-Boas F, Paraskevaidis I, Anastasiou-Nana M, Follath F. Acute heart failure in patients with diabetes mellitus: clinical characteristics and predictors of in hospital mortality. Int J Cardiol. 2012 May 17;157(1):108-13. 7 17. Yilmaz MB, Gayat E, Salem R, Lassus J, Nikolaou M, Laribi S, Parissis J, Follath F, Peacock WF, Mebazaa A. Impact of diuretic dosing on mortality in acute heart failure using a p r o p e n s i t y- m a t c h e d a n a l ys i s . Eur J Heart Fai l . 2011 Nov; 13(11): 1244 -52. 18. Ikonomidis I, Tzortzis S, Lekakis J, Paraskevaidis I, Dasou P, Parissis J, Nikolaou M, Markantonis SL, Katsimbri P, Skarantavos G, Andreadou I, Anastasiou-Nana M. Association of soluble apoptotic markers with impaired left ventricular deformation in patients with rheumatoid arthritis. Effects of inhibition of interleukin-1 activity by anakinra. Thromb Haemost. 2011 Nov;106(5):959-67. 19. Michalakeas CA, Parissis JT, Douzenis A, Nikolaou M, Varounis C, Andreadou I, Antonellos N, Markantonis-Kiroudis S, Paraskevaidis I, Ikonomidis I, Lykouras E, Kremastinos D. Effects of sertraline on circulating markers of oxidative stress in depressed patients with chronic heart failure: a pilot study J Card Fail. 2011 Sep;17(9):748-54 20. Papp Z, Édes I, Fruhwald S, De Hert SG, Salmenperä M, Leppikangas H, Mebazaa A, Landoni G, Grossini E, Caimmi P, Morelli A, Guarracino F, Schwinger RH, Meyer S, Algotsson L, Wikström BG, Jörgensen K, Filippatos G, Parissis JT, González MJ,Parkhomenko A, Yilmaz MB, Kivikko M, Pollesello P, Follath F. Levosimendan: Molecular mechanisms and clinical implications: consensus of experts on the mechanisms of action of levosimendan. Int J Cardiol. 2012 Aug 23;159(2):82-7. 21. Filippatos G, Parissis JT. Heart failure diagnosis and prognosis in the elderly: the proof of the pudding is in the eating. Eur J Heart Fail. 2011 May;13(5):467-71. 22. Ikonomidis I, Michalakeas CA, Lekakis J, Parissis J, Anastasiou-Nana M. The role of lipoprotein-associated phospholipase A2 (Lp-PLA₂ ) in cardiovascular disease. Rev Recent 8 Clin Trials. 2011 May;6(2):108-13. 23. Follath F, Yilmaz MB, Delgado JF, Parissis JT, Porcher R, Gayat E, Burrows N, McLean A, Vilas-Boas F, Mebazaa Clinical presentation, management and outcomes in the Acute Heart Failure Global Survey of Standard Treatment (ALARM-HF). Intensive Care Med.2011 Apr;37(4):619-26. 24. Koniari K, Nikolaou M, Paraskevaidis I, Parissis J. Therapeutic options for the management of the cardiorenal syndrome. Int J Nephrol. 2010 Dec 15;2011:194-199. 25. Paraskevaidis IA, Ikonomidis I, Parissis J, Papadopoulos C, Stassinos V, Bistola V, Anastasiou-Nana Dobutamine-induced changes of left atrial two-dimensional deformation predict clinical and neurohumoral improvement after levosimendan treatment in patients with acutely decompensated chronic heart failure. Int J Cardiol. 2012 May 17;157(1):31-7. 26. Gogas BD, Parissis JT, Iliodromitis EK, Tsiodras S, Radu M, Paraskevaidis IA, Theodoropoulos SP, Kremastinos DT, Yacoub MH. Left ventricular assist device vegetation: "cure" without device explantation. Hellenic J Cardiol. 2010 Nov-Dec;51(6):549-51. 27. Parissis JT, Ikonomidis I, Rafouli-Stergiou P, Mebazaa A, Delgado J, Farmakis D, VilasBoas F, Paraskevaidis I, Anastasiou-Nana M, Follath F. Clinical characteristics and predictors of in-hospital mortality in acute heart failure with preserved left ventricular ejection fraction. Am J Cardiol. 2011 Jan;107(1):79-84. 28. Mebazaa A, Parissis J, Porcher R, Gayat E, Nikolaou M, Boas FV, Delgado JF, Follath F. Short-term survival by treatment among patients hospitalized with acute heart failure: the global ALARM-HF registry using propensity scoring methods. Intensive Care Med. 2011Feb;37(2):290-301. 9 29. Parissis JT, Nikolaou M, Mebazaa A, Ikonomidis I, Delgado J, Vilas-Boas F, Paraskevaidis I, Mc Lean A, Kremastinos D, Follath F. Acute pulmonary oedema: clinical characteristics, prognostic factors, and in-hospital management. Eur J Heart Fail. 2010 Nov;12(11):1193-202. 30. Maggioni AP, Dahlström U, Filippatos G, Chioncel O, Leiro MC, Drozdz J, Fruhwald F, Gullestad L, Logeart D, Metra M, Parissis J, Persson H, Ponikowski P, Rauchhaus M, Voors A, Nielsen OW, Zannad F, Tavazzi L; Heart Failure Association of ESC (HFA). EURObservational Research Programme: the Heart Failure Pilot Survey (ESC-HF Pilot). Eur J Heart Fail. 2010 Oct;12(10):1076-84. 31. Ikonomidis I, Varounis C, Paraskevaidis I, Parissis J, Lekakis J, Anastasiou-Nana M. Congenital left ventricular aneurysm: a cause of impaired myocardial torsion and peripheral thrombo-embolic events. Eur J Echocardiogr. 2011 Feb;12(2):E7. 32. Parissis JT, Rafouli-Stergiou P, Stasinos V, Psarogiannakopoulos P, Mebazaa A. Inotropes in cardiac patients: update 2011. Curr Opin Crit Care. 2010 Oct;16(5):432-41. 33. Paraskevaidis IA, Tsougos E, Varounis C, Dagres N, Karatzas D, Parissis J, Kremastinos D. Exercise-induced changes of B-type natriuretic peptide uncover the unknown coronary artery disease in patients with chest pain and normal left ventricular systolic function. Eur J Cardiovasc Prev Rehabil. 2011 Feb;18(1):72-8. 34. Karavidas A, Parissis JT, Matzaraki V, Arapi S, Varounis C, Ikonomidis I, Grillias P, Paraskevaidis I, Pirgakis V, Filippatos G, Kremastinos DT. Functional electrical stimulation is more effective in severe symptomatic heart failure patients and improves their adherence to rehabilitation programs. J Card Fail. 2010 Mar;16(3):244-9. 35. Tzortzis S, Ikonomidis I, Lekakis J, Papadopoulos C, Triantafyllidi H, Parissis J, Trivilou P, Paraskevaidis I, Anastasiou-Nana M, Kremastinos DT.Incremental predictive value of 10 carotid intima-media thickness to arterial stiffness for impaired coronary flow reserve in untreated hypertensives. Hypertens Res . 2010 Apr;33(4):367 -73. 36. Bistola V, Parissis JT, Paraskevaidis I, Panou F, Nikolaou M, Ikonomidis I, Flessas N, Filippatos G, Iliodromitis E, Kremastinos DT. Prognostic value of tissue Doppler right ventricular systolic and diastolic function indexes combined with plasma B-type natriuretic Peptide in patients with advanced heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol. 2010 Jan 15;105(2):249-54. 37. Kremastinos DT, Hamodraka E, Parissis J, Tsiapras D, Dima K, Maisel A.Predictive value of B-type natriuretic peptides in detecting latent left ventricular diastolic dysfunction in beta-thalassemia major. Am Heart J. 2010 Jan;159(1):68-74. 38. Altenberger J, Parissis JT, Ulmer H, Poelzl G; LevoRep Investigators. Rationale and design of the multicentre randomized trial investigating the efficacy and safety of pulsed infusions of levosimendan in outpatients with advanced heart failure (LevoRep study).Eur J Heart Fail. 2010 Feb;12(2):186-92. 39. Farmakis D, Parissis J, Kremastinos DTThe prognostic role of echocardiographic indices in chronic heart failure: right ventricle revisited. Eur J Heart Fail. 2009 Dec;11(12):1220. 40. Ikonomidis I, Paraskevaidis I, Vamvakou G, Parissis J, Lekakis J. The antioxidant effects of granulocyte colony-stimulating factor. Heart. 2009 Nov;95(21):1801. 41. Parissis JT, Farmakis D, Nikolaou M, Birmpa D, Bistola V, Paraskevaidis I, Ikonomidis I, Gaitani S, Venetsanou K, Filippatos G, Kremastinos DT.Plasma B-type natriuretic peptide and anti-inflammatory cytokine interleukin-10 levels predict adverse clinical outcome in chronic heart failure patients with depressive symptoms: a 1-year follow-up study. Eur J Heart Fail. 2009 Oct;11(10):967-72. 11 42. Parissis JT, Filippatos G. Levosimendan in viral myocarditis: not only an inodilator but also a cardioprotector? Eur J Clin Invest. 2009 ;39(10):839-40. 43. Paraskevaidis IA, Farmakis D, Papadopoulos C, Ikonomidis I, Parissis J, Rigopoulos A, Iliodromitis EK, Kremastinos DT. Two-dimensional strain analysis in patients with hypertrophic cardiomyopathy and normal systolic function: a 12-month follow-up study. Am Heart J. 2009 ;158(3):444-50. 44. Gogas BD, Parissis JT, Filippatos GS, Iliodromitis EK, Soultanis KC, Kostopanagiotou GG, Theodoropoulos SP, Kremastinos DT, Yacoub MH. Severe anaemia and subcapital femur fracture in a patient with Left Ventricular Assist Device Heart Mate II: the cardiologist's management of this rare patient. Eur J Heart Fail. 2009;11(8):806-8. 45. Triposkiadis F, Parissis JT, Starling RC, Skoularigis J, Louridas G. Current drugs and medical treatment algorithms in the management of acute decompensated heart failure. Expert Opin Investig Drugs. 2009;18(6):695-707. 46. Parissis JT, Kourea K, Andreadou I, Ikonomidis I, Markantonis S, Ioannidis K, Paraskevaidis I, Iliodromitis E, Filippatos G, Kremastinos DT. Effects of Darbepoetin Alfa on plasma mediators of oxidative and nitrosative stress in anemic patients with chronic heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol. 2009 Apr 15;103(8):1134-8 47. Parissis JT, Nikolaou M, Farmakis D, Paraskevaidis IA, Bistola V, Venetsanou K, Katsaras D, Filippatos G, Kremastinos DT. Self-assessment of health status is associated with inflammatory activation and predicts long-term outcomes in chronic heart failure. Eur J Heart Fail. 2009;11(2):163-9. 48. Parissis JT, Rafouli-Stergiou P, Paraskevaidis I, Mebazaa A. Levosimendan: from basic science to clinical practice. Heart Fail Rev. 2009;14(4):265-75 12 49. Parissis JT, Nikolaou M, Birmpa D, Farmakis D, Paraskevaidis I, Bistola V, Katsoulas T, Filippatos G, Kremastinos DT. Clinical and prognostic value of Duke's Activity Status Index along with plasma B-type natriuretic peptide levels in chronic heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol. 2009;103(1):73-5. 50. Kirk JD, Parissis JT, Filippatos G. Pharmacologic stabilization and management of acute heart failure syndromes in the emergency department. Heart Fail Clin. 2009 ;5(1):43-54. 51. Lekakis J, Ikonomidis I, Papoutsi Z, Moutsatsou P, Nikolaou M, Parissis J, Kremastinos DT. Selective serotonin re-uptake inhibitors decrease the cytokine-induced endothelial adhesion molecule expression, the endothelial adhesiveness to monocytes and the circulating levels of vascular adhesion molecules. Int J Cardiol. 2008 Nov 10. 52. Farmakis D, Parissis JT, Bistola V, Paraskevaidis IA, Iliodromitis EK, Filippatos G, Kremastinos DT. Plasma B-type natriuretic peptide reduction predicts long-term response to levosimendan therapy in acutely decompensated chronic heart failure. Int J Cardiol. 2008 Oct 28. [Epub ahead of print] 53. Paraskevaidis IA, Bistola V, Ikonomidis I, Parissis JT, Papadopoulos C, Filippatos G, Kremastinos DT. Usefulness of dobutamine-induced changes of the two-dimensional longitudinal deformation predict clinical and neurohumoral improvement in men after levosimendan treatment in acutely decompensated chronic heart failure. Am J Cardiol. 2008;102(9):1225-9 54. Filippatos G, Parissis JT. Vasopressin antagonists for the treatment of acute decompensated heart failure: when, for whom, for how long, and on what standard therapy? J Card Fail. 2008;14(8):648-50. 55. Paraskevaidis IA, Panou F, Papadopoulos C, Farmakis D, Parissis J, Ikonomidis I, Rigopoulos A, Iliodromitis EK, Th Kremastinos D. Evaluation of left atrial longitudinal 13 function in patients with hypertrophic cardiomyopathy: a tissue Doppler imaging and twodimensional strain study. Heart. 2009;95(6):483-9. 56. Farmakis D, Filippatos G, Parissis J, Kremastinos DT, Gheorghiade M. Hyponatremia in heart failure. Heart Fail Rev. 2009 Jun;14(2):59-63. 57. Leftheriotis DI, Fountoulaki KT, Flevari PG, Parissis JT, Panou FK, Andreadou IT, Venetsanou KS, Iliodromitis EK, Kremastinos DT. The predictive value of inflammatory and oxidative markers following the successful cardioversion of persistent lone atrial fibrillation. Int J Cardiol. 2009 Jul 10;135(3):361-9. 58. Parissis JT, Andreadou I, Bistola V, Paraskevaidis I, Filippatos G, Kremastinos DT. Novel biologic mechanisms of levosimendan and its effect on the failing heart. Expert Opin Investig Drugs. 2008;17(8):1143-50. 59. Karavidas A, Parissis J, Arapi S, Farmakis D, Korres D, Nikolaou M, Fotiadis J, Potamitis N, Driva X, Paraskevaidis I, Matsakas E, Filippatos G, Kremastinos DT. Effects of functional electrical stimulation on quality of life and emotional stress in patients with chronic heart failure secondary to ischaemic or idiopathic dilated cardiomyopathy: a randomised, placebo-controlled trial. Eur J Heart Fail. 2008 ;10(7):709-13. 60. Gheorghiade M, Blair JE, Filippatos GS, Macarie C, Ruzyllo W, Korewicki J, BubenekTurconi SI, Ceracchi M, Bianchetti M, Carminati P, Kremastinos D, Valentini G, Sabbah HN; HORIZON-HF Investigators. Hemodynamic, echocardiographic, and neurohormonal effects of istaroxime, a novel intravenous inotropic and lusitropic agent: a randomized controlled trial in patients hospitalized with heart failure. J Am Coll Cardiol. 2008;51(23):2276-85. 61. Kourea K, Parissis JT, Farmakis D, Paraskevaidis I, Panou F, Filippatos G, Kremastinos DT. Effects of darbepoetin-alpha on quality of life and emotional stress in anemic patients with chronic heart failure. Eur J Cardiovasc Prev Rehabil 2008;15(3):365-9. 14 62. Blair JE, Macarie C, Ruzyllo W, Bacchieri A, Valentini G, Bianchetti M, Pang PS, Harinstein ME, Sabbah HN, Filippatos GS, Gheorghiade M; HORIZON-HF investigators. Rationale and design of the hemodynamic, echocardiographic and neurohormonal effects of istaroxime, a novel intravenous inotropic and lusitropic agent: a randomized controlled trial in patients hospitalized with heart failure (HORIZON-HF) trial. Am J Ther. 2008;15(3):231-40. 63. Karavidas A, Lazaros G, Matsakas E, Farmakis D, Parissis J, Paraskevaidis IA, Michailidis C, Avramidis D, Zacharoulis A, Arapi S, Kaoukis A, Zacharoulis A. Clinical value of B-type natriuretic peptide for the assessment of left ventricular filling pressures in patients with systolic heart failure and inconclusive tissue Doppler indexes. Heart Vessels. 2008;23(3):181-6. 64. Parissis JT, Kourea K, Panou F, Farmakis D, Paraskevaidis I, Ikonomidis I, Filippatos G, Kremastinos DT.Effects of darbepoetin alpha on right and left ventricular systolic and diastolic function in anemic patients with chronic heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am Heart J. 2008 Apr;155(4):751.e1-7 65. Farmakis D, Filippatos G, Lainscak M, Parissis JT, Anker SD, Kremastinos DT. Anticoagulants, antiplatelets, and statins in heart failure. Cardiol Clin. 2008 Feb;26(1):49-58. 66. De Luca L, Mebazaa A, Filippatos G, Parissis JT, Böhm M, Voors AA, Nieminen M, Zannad F, Rhodes A, El-Banayosy A, Dickstein K, Gheorghiade M. Overview of emerging pharmacologic agents for acute heart failure syndromes. Eur J Heart Fail. 2008 Feb;10(2):20113. Review. 67. Ikonomidis I, Parissis JT, Paraskevaidis I, Kourea K, Bistola V, Lekakis J, Filippatos G, Kremastinos DT. Effects of levosimendan on coronary artery flow and cardiac performance in patients with advanced heart failure. Eur J Heart Fail. 2007;9(12):1172-7. 15 68. Paraskevaidis IA, Kyrzopoulos S, Farmakis D, Parissis J, Tsiapras D, Iliodromitis EK, Kremastinos DT. Ventricular long-axis contraction as an earlier predictor of outcome in asymptomatic aortic regurgitation. Am J Cardiol. 2007 ;100(11):1677-82. 69. Kourea K, Parissis JT, Farmakis D, Panou F, Paraskevaidis I, Venetsanou K, Filippatos G, Kremastinos DT. Effects of darbepoetin-alpha on plasma pro-inflammatory cytokines, antiinflammatory cytokine interleukin-10 and soluble Fas/Fas ligand system in anemic patients with chronic heart failure. Atherosclerosis. 2008 Jul;199(1):215-21. 70. Parissis JT, Nikolaou M, Farmakis D, Bistola V, Paraskevaidis IA, Adamopoulos S, Filippatos G, Kremastinos DT. Clinical and prognostic implications of self-rating depression scales and plasma B-type natriuretic peptide in hospitalised patients with chronic heart failure. Heart. 2008;94(5):585-9. 71. Parissis JT, Andreadou I, Markantonis SL, Bistola V, Louka A, Pyriochou A, Paraskevaidis I, Filippatos G, Iliodromitis EK, Kremastinos DT. Effects of Levosimendan on circulating markers of oxidative and nitrosative stress in patients with advanced heart failure. Atherosclerosis. 2007;195(2):e210-5. 72. Parissis J, Fountoulaki K, Paraskevaidis I, Kremastinos DT. Sertraline for the treatment of depression in coronary artery disease and heart failure. Expert Opin Pharmacother. 2007 Jul;8(10):1529-37. 73. Parissis JT, Papadopoulos C, Nikolaou M, Bistola V, Farmakis D, Paraskevaidis I, Filippatos G, Kremastinos D. Effects of levosimendan on quality of life and emotional stress in advanced heart failure patients. Cardiovasc Drugs Ther. 2007;(4):263-8. 74. Parissis JT, Karavidas A, Bistola V, Arapi S, Paraskevaidis IA, Farmakis D, Korres D, Filippatos G, Matsakas E, Kremastinos DT. Effects of levosimendan on flow-mediated 16 vasodilation and soluble adhesion molecules in patients with advanced chronic heart failure.. Atherosclerosis. 2008 Mar;197(1):278-82. 75. Parissis JT, Farmakis D, Nieminen M. Classical inotropes and new cardiac enhancers. Heart Fail Rev. 2007;12(2):149-56. 76. Paraskevaidis IA, Kyrzopoulos S, Tsiapras D, Iliodromitis EK, Parissis J, Farmakis D, Kremastinos DT. The role of left ventricular long axis contraction in patients with asymptomatic non-ischemic mitral valve regurgitation and normal systolic function. Int J Cardiol. 2008 Feb 20;124(1):64-71. 77. Paraskevaidis I, Farmakis D, Parissis JT, Dodouras T, Filippatos G, Tsiapras D, Kremastinos DT. Carvedilol improves left atrial and left ventricular function and reserve in dilated cardiomyopathy after 1 year of treatment. J Card Fail. 2007;13(2):108-13 78. Parissis JT, Farmakis D, Bistola V, Adamopoulos S, Kremastinos DT. Levosimendan for the treatment of acute heart failure syndromes: time to identify subpopulations of responding patients. Am J Cardiol. 2007 Jan 1;99(1):146-7. 79. Flevari P, Parissis JT, Leftheriotis D, Panou F, Kourea K, Kremastinos DT. Effect of levosimendan on ventricular arrhythmias and prognostic autonomic indexes in patients with decompensated advanced heart failure secondary to ischemic or dilated cardiomyopathy. Am J Cardiol. 2006 Dec 15;98(12):1641-5. 80. Parissis JT, Paraskevaidis I, Bistola V, Farmakis D, Panou F, Kourea K, Nikolaou M, Filippatos G, Kremastinos D. Effects of levosimendan on right ventricular function in patients with advanced heart failure. Am J Cardiol. 2006 Dec 1;98(11):1489-92. 81. Parissis JT, Adamopoulos S, Farmakis D, Filippatos G, Paraskevaidis I, Panou F, Iliodromitis E, Kremastinos DT. Effects of serial levosimendan infusions on left ventricular 17 performance and plasma biomarkers of myocardial injury and neurohormonal and immune activation in patients with advanced heart failure. Heart. 2006 ;92(12):1768-72. 82. Paraskevaidis I, Parissis JT, Fountoulaki K, Filippatos G, Kremastinos D. Selective serotonin re-uptake inhibitors for the treatment of depression in coronary artery disease and chronic heart failure: evidence for pleiotropic effects. Cardiovasc Hematol Agents Med Chem. 2006 Oct;4(4):361-7. 83. Paraskevaidis IA, Vartela V, Tsiapras D, Iliodromitis EK, Parissis J, Farmakis D, Kremastinos DT. Tissue Doppler imaging analysis at pre-cardioversion time predicts recurrent atrial fibrillation: a 12-month follow-up study. J Cardiovasc Electrophysiol. 2006;17(9):100510. 84. Karavidas AI, Raisakis KG, Parissis JT, Tsekoura DK, Adamopoulos S, Korres DA, Farmakis D, Zacharoulis A, Fotiadis I, Matsakas E, Zacharoulis A. Functional electrical stimulation improves endothelial function and reduces peripheral immune responses in patients with chronic heart failure. Eur J Cardiovasc Prev Rehabil. 2006 Aug;13(4):592-7. 85. Parissis J, Filippatos G, Adamopoulos S, Li X, Kremastinos DT, Uhal BD. Hematopoietic colony stimulating factors in cardiovascular and pulmonary remodeling: promoters or inhibitors? Curr Pharm Des. 2006;12(21):2689-99. 86. Parissis JT, Fountoulaki K, Filippatos G, Adamopoulos S, Paraskevaidis I, Kremastinos D. Depression in coronary artery disease: novel pathophysiologic mechanisms and therapeutic implications. Int J Cardiol. 2007 Mar 20;116(2):153-60. 87. Adamopoulos S, Parissis JT, Iliodromitis EK, Paraskevaidis I, Tsiapras D, Farmakis D, Karatzas D, Gheorghiade M, Filippatos GS, Kremastinos DT. Effects of levosimendan versus dobutamine on inflammatory and apoptotic pathways in acutely decompensated chronic heart failure. Am J Cardiol. 2006 Jul 1;98(1):102-6. 18 88. Paraskevaidis IA, Tsiapras D, Kyrzopoulos S, Cokkinos P, Iliodromitis EK, Parissis J, Kremastinos DT. The role of left ventricular long-axis contraction in patients with asymptomatic aortic regurgitation. J Am Soc Echocardiogr. 2006;19(3):249-54. 89. Parissis JT, Farmakis D, Kremastinos DT. Levosimendan therapy in decompensated chronic heart failure: favourable haemodynamic and neurohormonal effects but for how long? Eur J Heart Fail. 2006 Mar;8(2):215 90. Parissis JT, Filippatos G, Farmakis D, Adamopoulos S, Paraskevaidis I, Kremastinos D. Levosimendan for the treatment of acute heart failure syndromes. Expert Opin Pharmacother. 2005 Dec;6(15):2741-51. 91. Parissis JT, Panou F, Farmakis D, Adamopoulos S, Filippatos G, Paraskevaidis I, Venetsanou K, Lekakis J, Kremastinos DT. Effects of levosimendan on markers of left ventricular diastolic function and neurohormonal activation in patients with advanced heart failure. Am J Cardiol. 2005 Aug 1;96(3):423-6. 92. Paraskevaidis IA, Parissis JT, Th Kremastinos D. Anti-inflammatory and anti-apoptotic effects of levosimendan in decompensated heart failure: a novel mechanism of drug-induced improvement in contractile performance of the failing heart. Curr Med Chem Cardiovasc Hematol Agents. 2005 Jul;3(3):243-7. 93. Parissis JT, Zezas S, Sfiras N, Kastellanos S. An atypical left atrial myxoma causing intracavitary pressure gradient and typical diastolic transmitral flow of severe mitral stenosis. Int J Cardiol. 2005 Jun 22;102(1):165-7. 94. Parissis JT, Fountoulaki K, Paraskevaidis I, Kremastinos D. Depression in chronic heart failure: novel pathophysiological mechanisms and therapeutic approaches. Expert Opin Investig Drugs. 2005 May;14(5):567-77. 19 95. Karas SM, Parissis JT, Antoniades C, Loulias A. A rare case of large mediastinal germ cell tumor detected by echocardiography. Int J Cardiol. 2005 May 11;101(1):159-61. 96. Parissis JT, Adamopoulos S, Karatzas D, Paraskevaidis J, Livanis E, Kremastinos D. Growth hormone-induced reduction of soluble apoptosis mediators is associated with reverse cardiac remodelling and improvement of exercise capacity in patients with idiopathic dilated cardiomyopathy. Eur J Cardiovasc Prev Rehabil. 2005 Apr;12(2):164-8 97. Parissis JT, Farmakis D, Kremastinos DT.Anti-inflammatory effects of levosimendan in decompensated heart failure: impact on weight loss and anemia. Am J Cardiol. 2005 Apr 1;95(7):923-4. 98. Kyrzopoulos S, Adamopoulos S, Parissis JT, Rassias J, Kostakis G, Iliodromitis E, Degiannis D, Kremastinos DT. Levosimendan reduces plasma B-type natriuretic peptide and interleukin 6, and improves central hemodynamics in severe heart failure patients. Int J Cardiol. 2005 Mar 30;99(3):409-13. 99. Markou N, Antzoulatos N, Haniotou A, Kanakaki M, Parissis J, Damianos A. A case of drug-induced pneumonitis caused by carvedilol. Respiration. 2004 Nov-Dec;71(6):650-2. 100. Tziakas D, Chalikias G, Parissis JT, Hatzinikolaou H, Stakos D, Papadopoulou E, Kortsaris A, Hatseras D. Prolonged activation of tumor necrosis factor (TNF)-alpha and its soluble receptors in chronic heart failure patients both in the compensated and decompensated state. Interplay between their levels and metalloproteinase-3. Eur Cytokine Netw. 2004 Jul Sep;15(3):231-9. 101. Parissis JT, Adamopoulos S, Rigas A, Kostakis G, Karatzas D, Venetsanou K, Kremastinos DT. Comparison of circulating proinflammatory cytokines and soluble apoptosis mediators in patients with chronic heart failure with versus without symptoms of depression. Am J Cardiol. 2004 Nov 15;94(10):1326-8 20 102. Adamopoulos S, Kokkinou S, Parissis JT, Kremastinos DT. New insight into "hearthand" syndromes: a newly discovered chromosomal abnormality in a family with "heart-hand" syndrome. Int J Cardiol. 2004 Oct;97(1):129-32. 103. Parissis JT, Adamopoulos S, Venetsanou K, Kostakis G, Rigas A, Karas SM, Kremastinos D. Plasma profiles of circulating granulocyte-macrophage colony-stimulating factor and soluble cellular adhesion molecules in acute myocardial infarction. Contribution to post-infarction left ventricular dysfunction. Eur Cytokine Netw. 2004 Apr-Jun;15(2):139-44. 104. Parissis JT, Bistola V, Kostakis GD, Adamopoulos S. Giant unruptured aneurysm of right valsalva sinus detected by magnetic resonance imaging. Int J Cardiol. 2004 Aug;96(2):299-301 105. Parissis JT, Adamopoulos S, Antoniades C, Kostakis G, Rigas A, Kyrzopoulos S, Iliodromitis E, Kremastinos D. Effects of levosimendan on circulating pro-inflammatory cytokines and soluble apoptosis mediators in patients with decompensated advanced heart failure. Am J Cardiol. 2004 May 15;93(10):1309-12. 106. Tziakas DN, Chalikias GK, Parissis JT, Hatzinikolaou EI, Papadopoulos ED, Tripsiannis GA, Papadopoulou EG, Tentes IK, Karas SM, Chatseras DI. Serum profiles of matrix metalloproteinases and their tissue inhibitor in patients with acute coronary syndromes. The effects of short-term atorvastatin administration. Int J Cardiol. 2004 Apr;94(2-3):269-77. 107. Tziakas DN, Chalikias GK, Hatzinikolaou HI, Parissis JT, Papadopoulos ED, Trypsianis GA, Papadopoulou E, Tentes IK, Karas SM, Hatseras DI. Anti-inflammatory cytokine profile in acute coronary syndromes: behavior of interleukin-10 in association with serum metalloproteinases and proinflammatory cytokines. Int J Cardiol. 2003;92(2-3):169-75. 108. Adamopoulos S, Parissis JT, Paraskevaidis I, Karatzas D, Livanis E, Georgiadis M, Karavolias G, Mitropoulos D, Degiannis D, Kremastinos DT. Effects of growth hormone on 21 circulating cytokine network, and left ventricular contractile performance and geometry in patients with idiopathic dilated cardiomyopathy. Eur Heart J. 2003 ;24(24):2186-96. 109. Parissis JT, Adamopoulos SN, Venetsanou KF, Karas SM, Kremastinos DT. Elevated plasma amylase levels in advanced chronic heart failure secondary to ischemic or idiopathic dilated cardiomyopathy: correlation with circulating interleukin-6 activity. J Interferon Cytokine Res. 2003 Jun;23(6):329-33. 110. Adamopoulos S, Parissis JT, Kremastinos DT.New aspects for the role of physical training in the management of patients with chronic heart failure. Int J Cardiol. 2003 Jul;90(1):1-14. 111. Filippatos G, Parissis JT.Estrogen administration in patients with chronic heart failure: not ready for prime time. Eur J Heart Fail. 2003 Mar;5(2):113-6. 112. Filippatos G, Parissis JT, Adamopoulos S, Kardaras F. Chemokines in cardiovascular remodeling: clinical and therapeutic implications. Curr Mol Med. 2003 Mar;3(2):139-47. 113. Karas S, Barbetseas J, Lambrou S, Parissis J, Metzikof D, Toutouzas P. Wellfunctioning double-orifice mitral valve in a young adult. J Clin Ultrasound. 2003 MarApr;31(3):170-3. 114. Parissis J, Filippatos G, Nikolaou V, Adamopoulos S. Cytokines and anti-cytokine therapeutic approaches to chronic heart failure. Eur J Intern Med. 2002 Sep;13(6):356. 115. Adamopoulos S, Parissis JT, Georgiadis M, Karatzas D, Paraskevaidis J, Kroupis C, Karavolias G, Koniavitou K, Kremastinos DT. Growth hormone administration reduces circulating proinflammatory cytokines and soluble Fas/soluble Fas ligand system in patients with chronic heart failure secondary to idiopathic dilated cardiomyopathy. Am Heart J. 2002 Aug;144(2):359-64. 22 116. Adamopoulos S, Parissis JT, Kremastinos DT. Endothelial dysfunction in chronic heart failure: clinical and therapeutic implications.Eur J Intern Med. 2002 Jun;13(4):233-239. 117. Parissis JT, Venetsanou KF, Kalantzi MV, Mentzikof DD, Karas SM.Serum profiles of granulocyte-macrophage colony-stimulating factor and C-C chemokines in hypertensive patients with or without significant hyperlipidemia. Am J Cardiol. 2000 Mar 15;85(6):777-9 118. Parissis JT, Korovesis S, Giazitzoglou E, Kalivas P, Katritsis D. Plasma profiles of peripheral monocyte-related inflammatory markers in patients with arterial hypertension. Correlations with plasma endothelin-1. Int J Cardiol. 2002 Apr;83(1):13-21. 119. Parissis JT, Adamopoulos S, Venetsanou KF, Mentzikof DG, Karas SM, Kremastinos DT. Serum profiles of C-C chemokines in acute myocardial infarction: possible implication in postinfarction left ventricular remodeling. J Interferon Cytokine Res. 2002 Feb;22(2):223-9. 120. Adamopoulos S, Parissis J, Karatzas D, Kroupis C, Georgiadis M, Karavolias G, Paraskevaidis J, Koniavitou K, Coats AJ, Kremastinos DT. Physical training modulates proinflammatory cytokines and the soluble Fas/soluble Fas ligand system in patients with chronic heart failure. J Am Coll Cardiol. 2002 Feb 20;39(4):653-63. 121. Adamopoulos S, Parissis JT, Kremastinos DT. A glossary of circulating cytokines in chronic heart failure. Eur J Heart Fail. 2001 Oct;3(5):517-26. 122. Parissis JT, Venetsanou KF, Mentzikof DG, Kalantzi MV, Georgopoulou MV, Chrisopoulos N, Karas SM. Plasma levels of soluble cellular adhesion molecules in patients with arterial hypertension. Correlations with plasma endothelin-1. Eur J Intern Med. 2001 Jul;12(4):350-356. 123. Adamopoulos S, Parissis J, Kroupis C, Georgiadis M, Karatzas D, Karavolias G, Koniavitou K, Coats AJ, Kremastinos DT. Physical training reduces peripheral markers of inflammation in patients with chronic heart failure. Eur Heart J. 2001 May;22(9):791-7. 23 124. Katritsis D, Korovesis S, Giazitzoglou E, Parissis J, Kalivas P, Webb-Peploe MM, Ioannidis JP, Haliassos A. C-Reactive protein concentrations and angiographic characteristics of coronary lesions. Clin Chem. 2001 May;47(5):882-6. 125. Katritsis DG, Ioannidis JP, Korovesis S, Giazitzoglou E, Parissis J, Kalivas P, WebbPeploe MM. Comparison of myocardial fractional flow reserve and intravascular ultrasound for the assessment of slotted-tube stents. Catheter Cardiovasc Interv. 2001 Mar;52(3):322-6 126. Flouris GA, Arvanitis DA, Parissis JT, et. al. Loss of heterozygosity in DNA mismatch repair genes in human atherosclerotic plaques. Mol Cell Biol Res Commun. 2000 Jul;4(1):625. 127. Parissis JT, Adamopoulos S, Venetsanou KF, Mentzikof DG, Karas SM, Kremastinos DT. Clinical and neurohormonal correlates of circulating granulocyte-macrophage colonystimulating factor in severe heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol. 2000 Sep 15;86(6):707-10, A9-10. 128. Sourvinos G, Parissis J, Sotsiou F, et al.. Detection of microsatellite instability in sporadic cardiac myxomas. Cardiovasc Res. 1999 Jun;42(3):728-32. 129. Parissis JT, Venetsanou KF, Mentzikof DG, et al . Tumor necrosis factor-alpha serum activity during treatment of acute decompensation of cachectic and non-cachectic patients with advanced congestive heart failure. Scand Cardiovasc J. 1999;33(6):344-50. 130. Parissis JT, Mentzikof D, Georgopoulou M, et al. Correlation of interleukin-6 gene expression to immunologic features in patients with cardiac myxomas. J Interferon Cytokine Res. 1996 Aug;16(8):589-93. Oncology : 24 1. Lygidakis NJ, Ziras FA, Kyparidou E, Parissis J, Papadopoulou P, Venetsanou B. Combined immunopharmaceutical therapy of patients with unresectable pancreatic carcinoma. Hepatogastroenterology. 1995 Nov-Dec;42(6):1039-52. 2. Lygidakis NJ, Kosmidis P, Ziras N, Parissis J, Kyparidou E. Combined transarterial targeting locoregional immunotherapy-chemotherapy for patients with unresectable hepatocellular carcinoma: a new alternative for an old problem. J Interferon Cytokine Res. 1995 May;15(5):467-72. 3. Lygidakis NJ, Ziras N, Parissis J. Resection versus resection combined with adjuvant preand post-operative chemotherapy--immunotherapy for metastatic colorectal liver cancer. A new look at an old problem. Hepatogastroenterology. 1995 Apr;42(2):155-61. Editorial Board: American Journal of Cardiovascular Disease, Reviewer: 1. LANCET 2. Circulation 3. Journal of American College of Cardiology 4. European Heart Journal 5. Atherosclerosis 6. European Journal of Heart Failure 7. American Journal of Cardiology 8. American Heart Journal 9. International Journal of Cardiology 10. Journal of Cardiac Failure 11. Heart 12. Clinical Research in Cardiology 13. Intensive Care Medicine 25 14. Heart Failure Reviews 15. Cardiovascular Drugs and Therapy 16. Coronary Artery Disease 17. Clinical Science (London) 18. European Journal of Clinical Investigation 19. Psychosomatic Medicine 20. Brain Behavior and Immunity 21. European Cytokine Network 22. American Journal of Cardiovascular Drugs 23. Expert Opinion on Investigational Drugs 24. Expert Opinion on Pharmacotherapy 25. Herz 26. Anatolian Journal of Cardiology 27. Hellenic Journal of Cardiology Chapters in international books: 1) “S Adamopoulos, K Fountoulaki, J Parissis: Exercise testing in coronary heart disease” in Cardiovascular prevention and rehabilitation, Spinger-Verlag London 2007 (Eds J Perk, H Saner). 2) “Kremastinos D, Parissis J, Filippatos G: Acute Heat Failure Syndromes in BetaThalassemia” in Mebazaa A, Georghiade M, Zannad F, Parillo GA. Eds Acute Heart Failure, Spinger-Verlag, 2008;297-305. 3) “ Parissis J, Nikolaou M, Tsitlakidis K, Filippatos G, Kremastinos D. Depression in chronic heart failure: epidemiology pathophysiology, and diagnostic tools” Chapter VIII in Leo Sher (Ed): Psychosocial factors and cardiovascular disorders: the role of psychiatric pathology and maladaptive personality features” Nova Science publihers, Inc. (p111-123). 26 4) “Parissis J, Birmpa D. Acute heart failure: early pharmacological management” Chapter 50 in The European Society of Cardiology Textbook of Intensive and Acute Cardiac Care. Oxford University Press 2011 (p491-502). 27