NAVBO's Vascular Biology Publication Alert
May 2015 Issue (papers published in April 2015)
NAVBO Members are highlighted in dark red
American Journal of Pathology
Shawn K Ahlfeld, Yong Gao, Simon J Conway, Robert S Tepper. Relationship of Structural to Functional
Impairment during Alveolar-Capillary Membrane Development. Am J Pathol., 185(4):913–919
Alec Falkenham, Roberto de Antueno, Nicole Rosin, Devin Betsch, Timothy D G Lee, Roy Duncan, Jean-Francois
Légaré. Nonclassical resident macrophages are important determinants in the development of myocardial
fibrosis. Am J Pathol., 185(4):927–942
Gustaf Christoffersson, Tomas Waldén, Monica Sandberg, Ghislain Opdenakker, Per-Ola Carlsson, Mia Phillipson.
Matrix metalloproteinase-9 is essential for physiological Beta cell function and islet vascularization in adult
mice. Am J Pathol., 185(4):1094–1103
Emiel P C van der Vorst, Mike Jeurissen, Ine M J Wolfs, Anke Keijbeck, Kosta Theodorou, Erwin Wijnands, Leon
Schurgers, Silvio Weber, Marion J Gijbels, Anouk A J Hamers, Daniela Dreymueller, Stefan Rose-John, Menno P J
de Winther, Andreas Ludwig, Paul Saftig, Erik A L Biessen, Marjo M P C Donners. Myeloid A Disintegrin and
Metalloproteinase Domain 10 Deficiency Modulates Atherosclerotic Plaque Composition by Shifting the
Balance from Inflammation toward Fibrosis. Am J Pathol., 185(4):1145–1155
Figueiredo JL, Aikawa M, Zheng C, Aaron J, Lax L, Libby P, de Lima Filho JL, Gruener S, Fingerle J, Haap W,
Hartmann G, Aikawa E. Selective cathepsin S inhibition attenuates atherosclerosis in apolipoprotein Edeficient mice with chronic renal disease. Am J Pathol., 185(4):1156-66
Biochemical Journal
No vascular biology related publications this month
Blood
Freda H. Passam, Lin Lin, Srila Gopal, Jack D. Stopa, Lola Bellido-Martin, Mingdong Huang, Barbara C. Furie, Bruce
Furie. Both platelet- and endothelial cell–derived ERp5 support thrombus formation in a laser-induced mouse
model of thrombosis. Blood: 125(14):2276-85
Cancer Cell
No vascular biology related publications this month
Cancer Research
Debarshi Banerjee, Sonia L. Hernandez, Alejandro Garcia, Thaned Kangsamaksin, Emily Sbiroli, John Andrews,
Lynn Ann Forrester, Na Wei, Angela Kadenhe-Chiweshe, Carrie J. Shawber, Jan K. Kitajewski, Jessica J. Kandel,
Darrell J. Yamashiro. Notch Suppresses Angiogenesis and Progression of Hepatic Metastases. Cancer Res.,
75:1592-1602
Cell
No vascular biology related publications this month
Clinical Science
Thiago Bruder-Nascimento, Glaucia E Callera, Augusto C Montezano, Ying He, Tayze T Antunes, Aurelie Nguyen
Dinh Cat, Rita C Tostes, Rhian M Touyz. Vascular injury in diabetic db/db mice is ameliorated by atorvastatin:
role of Rac1/2-sensitive Nox-dependent pathways. Clin Sci (Lond)., 128(7):411–423
Yi-Ching Chen, Ching-Wen Ho, Hsing-Hua Tsai, Jong-Shyan Wang. Interval and continuous exercise regimens
suppress neutrophil-derived microparticle formation and neutrophil-promoted thrombin generation under
hypoxic stress. Clin Sci (Lond)., 128(7):425–436
Javier Rodríguez-Carrio, Mercedes Alperi-López, Patricia López, Sara Alonso-Castro, Santiago R Carro-Esteban,
Francisco J Ballina-García, Ana Suárez. Altered profile of circulating microparticles in rheumatoid arthritis
patients. Clin Sci (Lond)., 128(7):437–448
Mamoru Satoh, Yuji Takahashi, Tsuyoshi Tabuchi, Makiko Tamada, Kan Takahashi, Tomonori Itoh, Yoshihiro
Morino, Motoyuki Nakamura. Circulating Toll-like receptor 4-responsive microRNA panel in patients with
coronary artery disease: results from prospective and randomized study of treatment with renin-angiotensin
system blockade. Clin Sci (Lond)., 128(8):483–491
Shanshan Gao, Weimin Liu, Xiaozhen Zhuo, Lijun Wang, Gang Wang, Tao Sun, Zhao Zhao, Junhui Liu, Yuling Tian,
Juan Zhou, Zuyi Yuan, Yue Wu. The activation of mTOR is required for monocyte pro-inflammatory response
in patients with coronary artery disease. Clin Sci (Lond)., 128(8):517–526
Development
No vascular biology related publications this month
Developmental Biology
No vascular biology related publications this month
Developmental Cell
No vascular biology related publications this month
Developmental Dynamics
Jamie A. Havrilak and John M. Shannon. Branching of lung epithelium in vitro occurs in the absence of
endothelial cells. Dev. Dyn., 244(4):553-63
EMBO
No vascular biology related publications this month
EMBO Reports
Andrew C Hedman, Jessica M Smith, David B Sacks. The biology of IQGAP proteins: beyond the cytoskeleton.
EMBO reports, 16(4):427-446
FASEB Journal
Di Jia, Lan Huang, Joyce Bischoff, and Marsha A. Moses. The endogenous zinc finger transcription factor,
ZNF24, modulates the angiogenic potential of human microvascular endothelial cells. FASEB J., 29:1371-1382
Sylwia Bartoszewska, Kinga Kochan, Arkadiusz Piotrowski, Wojciech Kamysz, Renata J. Ochocka, James F.
Collawn, and Rafal Bartoszewski. The hypoxia-inducible miR-429 regulates hypoxia-inducible factor-1α
expression in human endothelial cells through a negative feedback loop. FASEB J., 29:1467-1479
Li-Na Wei and Ethan Dmintrovsky. Retinoids Are Back. FASEB J., 29:1131-1135
Aino Salminen, Pirjo Åström, Jari Metso, Rabah Soliymani, Tuula Salo, Matti Jauhiainen, Pirkko J. Pussinen, and
Timo Sorsa. Matrix metalloproteinase 8 degrades apolipoprotein A-I and reduces its cholesterol efflux
capacity. FASEB J., 29:1435-1445
Diana M. Shih, Janet M. Yu, Laurent Vergnes, Nassim Dali-Youcef, Matthew D. Champion, Asokan Devarajan,
Peixiang Zhang, Lawrence W. Castellani, David N. Brindley, Carole Jamey, Johan Auwerx, Srinivasa T. Reddy,
David A. Ford, Karen Reue, and Aldons J. Lusis. PON3 knockout mice are susceptible to obesity, gallstone
formation, and atherosclerosis. FASEB J., 29:1185-1197
Genes & Development
Colleen Wu, Erinn B. Rankin, Laura Castellini, Javier Fernandez-Alcudia, Edward L. LaGory, Rebecca Andersen,
Steven D. Rhodes, Tremika L.S. Wilson, Khalid S. Mohammad, Alesha B. Castillo, Theresa A. Guise, Ernestina
Schipani, and Amato J. Giaccia. Oxygen-sensing PHDs regulate bone homeostasis through the modulation of
osteoprotegerin. Genes Dev., 29:817-831
Anat Biran, Meirav Perelmutter, Hilah Gal, Dominick G.A. Burton, Yossi Ovadya, Ezra Vadai, Tamar Geiger, and
Valery Krizhanovsky. Senescent cells communicate via intercellular protein transfer. Genes Dev., 29:791-802
Journal of Biological Chemistry
Ryan D. Mills, Mitsuo Mita, Jun-ichi Nakagawa, Masaru Shoji, Cindy Sutherland, and Michael P. Walsh. A Role for
the Tyrosine Kinase Pyk2 in Depolarization-induced Contraction of Vascular Smooth Muscle. J. Biol. Chem.,
290:8677-8692
Mykhaylo V. Artamonov, Li Jin, Aaron S. Franke, Ko Momotani, Ruoya Ho, Xiu Rong Dong, Mark W. Majesky, and
Avril V. Somlyo. Signaling Pathways That Control Rho Kinase Activity Maintain the Embryonic Epicardial
Progenitor State. J. Biol. Chem., 290:10353-10367
Tao Wang, Ruping Wang, Rachel A. Cleary, Olivia J. Gannon, and Dale D. Tang. Recruitment of β-Catenin to NCadherin Is Necessary for Smooth Muscle Contraction. J. Biol. Chem., 290:8913-8924
Haiming Xu, Nikolay L. Malinin, Niranjan Awasthi, Roderich E. Schwarz, and Margaret A. Schwarz. The N Terminus
of Pro-endothelial Monocyte-activating Polypeptide II (EMAP II) Regulates Its Binding with the C Terminus,
Arginyl-tRNA Synthetase, and Neurofilament Light Protein. J. Biol. Chem., 290:9753-9766
A Tyrosine Kinase Plays an Important Role in the Sustained Contraction of Vascular Smooth Muscle: A Role
for the Tyrosine Kinase Pyk2 in Depolarization-induced Contraction of Vascular Smooth Muscle. J. Biol.
Chem., 290:8693
Reddy Peera Kommaddi, Pierre-Yves Jean-Charles, and Sudha K. Shenoy. Phosphorylation of the
Deubiquitinase USP20 by Protein Kinase A Regulates Post-endocytic Trafficking of β2 Adrenergic Receptors
to Autophagosomes during Physiological Stress. J. Biol. Chem., 290:8888-8903
Journal of Cell Biology
No vascular biology related publications this month
Journal of Cell Science
Cristina Bardita, Dan N. Predescu, Fei Sha, Monal Patel, Ganesh Balaji, and Sanda A. Predescu. Endocytic
deficiency induced by ITSN‐1s knockdown alters the Smad2/3‐Erk1/2 signaling balance downstream of Alk5.
J Cell Sci., 128:1528-1541
Hayri E. Balcioglu, Hedde van Hoorn, Dominique M. Donato, Thomas Schmidt, and Erik H. J. Danen. The integrin
expression profile modulates orientation and dynamics of force transmission at cell–matrix adhesions. J Cell
Sci., 128:1316-1326
Adrienne K. Barry, Ning Wang, and Deborah E. Leckband. Local VE-cadherin mechanotransduction triggers
long-ranged remodeling of endothelial monolayers. J Cell Sci., 128:1341-1351
Journal of Clinical Investigation
Issaka Yougbaré, Sean Lang, Hong Yang, Pingguo Chen, Xu Zhao, Wei-She Tai, Darko Zdravic, Brian Vadasz,
Conglei Li1, Siavash Piran, Alexandra Marshall, Guangheng Zhu, Heidi Tiller, Mette Kjaer Killie, Shelley Boyd,
Howard Leong-Poi, Xiao-Yan Wen, Bjorn Skogen, S. Lee Adamson, John Freedman9, and Heyu Ni. Maternal antiplatelet β3 integrins impair angiogenesis and cause intracranial hemorrhage. J Clin Invest., 125(4):1545-1556
Journal of Experimental Medicine
Laurence E. Cheng, Brandon M. Sullivan, Lizett E. Retana, Christopher D.C. Allen, Hong-Erh Liang, and Richard M.
Locksley. IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function. J. Exp
Med., 212(4)513-524
Journal of Immunology
Shan Lu, Hequan Li, Rundi Gao, Xuan Gao, Fei Xu, Qing Wang, Guohua Lu, Dajing Xia, and Jianying Zhou. IL-17A,
But Not IL-17F, Is Indispensable for Airway Vascular Remodeling Induced by Exaggerated Th17 Cell
Responses in Prolonged Ovalbumin-Challenged Mice. J Immunol., 194:3557-3566
Michael Schnoor. Endothelial Actin-Binding Proteins and Actin Dynamics in Leukocyte Transendothelial
Migration. J Immunol., 194:3535-3541
Eloy Cuadrado, Iliana Michailidou, Emma J. van Bodegraven, Machiel H. Jansen, Jacqueline A. Sluijs, Dirk Geerts,
Pierre-Olivier Couraud, Lidia De Filippis, Angelo L. Vescovi, Taco W. Kuijpers, and Elly M. Hol. Phenotypic
Variation in Aicardi–Goutières Syndrome Explained by Cell-Specific IFN-Stimulated Gene Response and
Cytokine Release. J Immunol., 194:3623-3633
Hengameh Sadeghi, Anike Lockmann, Anna-Carina Hund, Unni K. S. R. L. Samavedam, Elena Pipi, Katerina Vafia,
Eva Hauenschild, Kathrin Kalies, Hendri H. Pas, Marcel F. Jonkman, Hiroaki Iwata, Andreas Recke, Michael P.
Schön, Detlef Zillikens, Enno Schmidt, and Ralf J. Ludwig. Caspase-1–Independent IL-1 Release Mediates Blister
Formation in Autoantibody-Induced Tissue Injury through Modulation of Endothelial Adhesion Molecules. J
Immunol., 194:3656-3663
Journal of Lipid Research
No vascular biology related publications this month
Molecular and Cellular Biology
Shan Wang, Katherine R. Amato, Wenqiang Song, Victoria Youngblood, Keunwook Lee, Mark Boothby, Dana M.
Brantley-Sieders, and Jin Chen. Regulation of Endothelial Cell Proliferation and Vascular Assembly through
Distinct mTORC2 Signaling Pathways. Mol. Cell. Biol., 35:1299-1313
Lee HS, Cheerathodi M, Chaki SP, Reyes SB, Zheng Y, Lu Z, DerMardirossian C, Lacy-Hulbert A, Rivera
GM, McCarty JH. PTP-PEST and β8 Integrin Control Spatiotemporal Patterns of RhoGDI1 Activation in
Migrating Cells. Mol Cell Biol., 35(8):1401-13
Molecular Biology of the Cell
No vascular biology related publications this month
Nature
Sandra Schoors, Ulrike Bruning, Rindert Missiaen, Karla C S Queiroz, Gitte Borgers, Ilaria Elia, Annalisa Zecchin,
Anna Rita Cantelmo, Stefan Christen, Jermaine Goveia, Ward Heggermont, Lucica Goddé, Stefan Vinckier, Paul P
Van Veldhoven, Guy Eelen, Luc Schoonjans, Holger Gerhardt, Mieke Dewerchin, Myriam Baes, Katrien De Bock,
Bart Ghesquière, Sophia Y Lunt, Sarah-Maria Fendt, Peter Carmeliet. Fatty acid carbon is essential for dNTP
synthesis in endothelial cells. Nature, 520(7546):192–197
Mary J C Hendrix. Cancer: An extravascular route for tumour cells. Nature, 520(7547):300–302
Elvin Wagenblast, Mar Soto, Sara Gutiérrez-Ángel, Christina A Hartl, Annika L Gable, Ashley R Maceli, Nicolas
Erard, Alissa M Williams, Sun Y Kim, Steffen Dickopf, J Chuck Harrell, Andrew D Smith, Charles M Perou, John E
Wilkinson, Gregory J Hannon, Simon R V Knott. A model of breast cancer heterogeneity reveals vascular
mimicry as a driver of metastasis. Nature, 520(7547):358–362
Dohoon Kim, Brian P Fiske, Kivanc Birsoy, Elizaveta Freinkman, Kenjiro Kami, Richard L Possemato, Yakov
Chudnovsky, Michael E Pacold, Walter W Chen, Jason R Cantor, Laura M Shelton, Dan Y Gui, Manjae Kwon, Shakti
H Ramkissoon, Keith L Ligon, Seong Woo Kang, Matija Snuderl, Matthew G Vander Heiden, David M Sabatini.
SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance. Nature,
520(7547):363–367
Schoors S, Bruning U, Missiaen R, Queiroz KC, Borgers G, Elia I, Zecchin A, Cantelmo AR, Christen S, Goveia J,
Heggermont W, Goddé L, Vinckier S, Van Veldhoven PP, Eelen G, Schoonjans L, Gerhardt H, Dewerchin M, Baes
M, De Bock K, Ghesquière B, Lunt SY, Fendt SM, Carmeliet P. Fatty acid carbon is essential for dNTP synthesis
in endothelial cells. Nature, 520(7546):192-7
Nature Cell Biology
Hu Zhao, Jifan Feng, Thach-Vu Ho, Weston Grimes, Mark Urata, Yang Chai. The suture provides a niche for
mesenchymal stem cells of craniofacial bones. Nat Cell Biol., 17(4):386–396
Iqbal Dulloo, Beng Hooi Phang, Rashidah Othman, Soo Yong Tan, Aadhitthya Vijayaraghavan, Liang Kee Goh,
Marta Martin-Lopez, Margarita M Marques, Chun Wei Li, De Yun Wang, Maria Carmen Marín, Wa Xian, Frank
McKeon, Kanaga Sabapathy. Hypoxia-inducible TAp73 supports tumorigenesis by regulating the angiogenic
transcriptome. Nat Cell Biol., 17(4):511–523
Nature Genetics
Xiaoling Zhang, Roby Joehanes, Brian H Chen, Tianxiao Huan, Saixia Ying, Peter J Munson, Andrew D Johnson,
Daniel Levy, Christopher J O'Donnell. Identification of common genetic variants controlling transcript isoform
variation in human whole blood. Nat Genet., 47(4):345–352
Nature Medicine
Holger Lörchner, Jochen Pöling, Praveen Gajawada, Yunlong Hou, Viktoria Polyakova, Sawa Kostin, Juan M AdrianSegarra, Thomas Boettger, Astrid Wietelmann, Henning Warnecke, Manfred Richter, Thomas Kubin, Thomas Braun.
Myocardial healing requires Reg3β-dependent accumulation of macrophages in the ischemic heart. Nat Med.,
21(4):353–362
PNAS
Humera Tariq, Jordi Bella, Thomas A. Jowitt, David F. Holmes, Mansour Rouhi, Zhuxiang Nie, Clair Baldock, David
Garrod, and Lydia Tabernero. Cadherin flexibility provides a key difference between desmosomes and
adherens junctions. PNAS, 112(17):5395-5400
Kathryn B. Smedlund, Lutz Birnbaumer, and Guillermo Vazquez. Increased size and cellularity of advanced
atherosclerotic lesions in mice with endothelial overexpression of the human TRPC3 channel. PNAS,
112(17):E2201-E2206
Catherine K. Hathaway, Ruriko Grant, John R. Hagaman, Sylvia Hiller, Feng Li, Longquan Xu, Albert S. Chang,
Victoria J. Madden, C. Robert Bagnell, Mauricio Rojas, Hyung-Suk Kim, Bingruo Wu, Bin Zhou, Oliver Smithies, and
Masao Kakoki. Endothelin-1 critically influences cardiac function via superoxide-MMP9 cascade. PNAS,
112(16):5141-5146
Alexandra Berdichevski, Haneen Simaan Yameen, Hagit Dafni, Michal Neeman, and Dror Seliktar. Using bimodal
MRI/fluorescence imaging to identify host angiogenic response to implants. PNAS, 112(16):5147-5152
Umit A. Kayisli, Murat Basar, Ozlem Guzeloglu-Kayisli, Nihan Semerci, Helen C. Atkinson, John Shapiro, Taryn
Summerfield, S. Joseph Huang, Katja Prelle, Frederick Schatz, and Charles J. Lockwood. Long-acting progestinonly contraceptives impair endometrial vasculature by inhibiting uterine vascular smooth muscle cell
survival. PNAS, 112(16):5153-5158
Fong Ming Koh, Carlos O. Lizama, Priscilla Wong, John S. Hawkins, Ann C. Zovein, and Miguel Ramalho-Santos.
Emergence of hematopoietic stem and progenitor cells involves a Chd1-dependent increase in total nascent
transcription. PNAS, 112(14):E1734-E1743
Jianhe Huang, Tao Wang, Alexander C. Wright, Jifu Yang, Su Zhou, Li Li, Jisheng Yang, Aeron Small, and Michael
S. Parmacek. Myocardin is required for maintenance of vascular and visceral smooth muscle homeostasis
during postnatal development. PNAS, 112(14):4447-4452
Science
No vascular biology related publications this month
Member Submissions
Serhan CN, Dalli J, Colas RA, Winkler JW, Chiang N. Protectins and maresins: new pro-resolving families of
mediators in acute inflammation and resolution bioactive metabolome. Biochim Biophys Acta., 1851(4):397-413
Boscolo E, Coma S, Luks VL, Greene AK, Klagsbrun M, Warman ML, Bischoff J. AKT hyper-phosphorylation
associated with PI3K mutations in lymphatic endothelial cells from a patient with lymphatic malformation.
Angiogenesis, 18(2):151-62
Mark H. M. Vries, Allard Wagenaar, Sanne E. L. Verbruggen, Daniel G. M. Molin, Mark J. Post. CXCL1 promotes
arteriogenesis through enhanced monocyte recruitment into the peri-collateral space. Angiogenesis,
18(2):163-71
Diaz JA, Wrobleski SK, Alvarado CM, Hawley AE, Doornbos NK, Lester PA, Lowe SE, Gabriel JE, Roelofs KJ,
Henke PK, Schaub RG, Wakefield TW, Myers DD Jr. P-Selectin Inhibition Therapeutically Promotes Thrombus
Resolution and Prevents Vein Wall Fibrosis Better Than Enoxaparin and an Inhibitor to von Willebrand
Factor. Arterioscler Thromb Vasc Biol., 35(4):829-37
Han J, Calvo CF, Kang TH, Baker KL, Park JH, Parras C, Levittas M, Birba U, Pibouin-Fragner L, Fragner P, Bilguvar
K, Duman RS, Nurmi H, Alitalo K, Eichmann AC, Thomas JL. Vascular endothelial growth factor receptor 3
controls neural stem cell activation in mice and humans. Cell Rep., 10(7):1158-72
Balenga NA, Klichinsky M, Xie Z, Chan EC, Zhao M, Jude J, Laviolette M, Panettieri RA Jr, Druey KM. A fungal
protease allergen provokes airway hyper-responsiveness in asthma. Nat Commun., 6:6763.
Hsu P, Xie Z, Frith K, Wong M, Kakakios A, Stone KD, Druey KM. Idiopathic systemic capillary leak syndrome in
children. Pediatrics, 135(3):e730-5
Cook JR, Clayton NP, Carta L, Galatioto J, Chiu E, Smaldone S, Nelson CA, Cheng SH, Wentworth BM, Ramirez F.
Dimorphic Effects of Transforming Growth Factor-β Signaling During Aortic Aneurysm Progression in Mice
Suggest a Combinatorial Therapy for Marfan Syndrome. Arterioscler Thromb Vasc Biol., 35(4):911-7
Mikelis CM, Simaan M, Ando K, Fukuhara S, Sakurai A, Amornphimoltham P, Masedunskas A, Weigert R, Chavakis
T, Adams RH, Offermanns S, Mochizuki N, Zheng Y, Gutkind JS. RhoA and ROCK mediate histamine-induced
vascular leakage and anaphylactic shock. Nat Commun., 6:6725
Mui KL, Bae YH, Gao L, Liu SL, Xu T, Radice GL, Chen CS, Assoian RK. N-Cadherin Induction by ECM Stiffness
and FAK Overrides the Spreading Requirement for Proliferation of Vascular Smooth Muscle Cells. Cell Rep.,
10(9):1477-1486
Xiao L, Kim DJ, Davis CL, McCann JV, Dunleavey JM, Vanderlinden A, Xu N, Pattenden SG, Frye SV Ph D, Xu X,
Onaitis M, Monaghan-Benson E, Burridge K, Dudley AC. Tumor endothelial cells with distinct patterns of TGFβdriven endothelial-to-mesenchymal transition. Cancer Res. 75(7):1244-54
Libby P. Triglycerides on the rise: Should we swap seats on the seesaw? Eur Heart J., 36(13):774-776
Diaz JA, Farris DM, Wrobleski SK, Myers DD, Wakefield TW. Inferior vena cava branch variations in C57BL/6
mice have an impact on thrombus size in an IVC ligation (stasis) model. J Thromb Haemost., 13(4):660-4
William Durante. Bilirubin: striking gold in diabetic vasculopathy? Diabetes, 64:1506-1508
Besschetnova TY, Ichimura T, Katebi N, St Croix B, Bonventre JV, Olsen BR. Regulatory mechanisms of anthrax
toxin receptor 1-dependent vascular and connective tissue homeostasis. Matrix Biol., 42:56-73