國立陽明大學校長遴選委員會 社會公正人士代表推薦書 被推薦人個人資料如下: 姓 名 戚謹文 性 別 現 機 關 ( 構 ) 台北榮總教研部 名 職地 學 職 稱 電話(O) 傳 真 (O) 址 歷 ■ E-Mail(O) 學 校 名 稱 科 系 組 所 名 稱學 (請填學校全銜) 生理系 博士 取 得 學 位 之 學 歷 美國紐約州立大學水牛 生物系 碩士 生物系 學士 私立輔仁大學 經 服 務 機 關 ( 構 ) 名 稱 職 稱 位 名 稱 迄 年 月 起 國立陽明大學醫學院 副院長 2005 /08 國立陽明大學藥理學研究所 所長 2002 /08 至 2008 /07 台北榮民總醫院醫學研究部 研究員 1991 /08 至 present 台北榮民總醫院一般外科 技師 1979 /05 至 1986 /07 歷 美國紐約州立大學水牛分校藥理系 博士後研究員 女 稱 教授 美國紐約州立大學水牛 請填大學(含)以上已 男 1986 /05 至 1986 /06 學 術 成 如附件 就 推薦單位:陽明大學醫學院 備註: 1. 社會公正人士,由各學院推薦或教師 15 人以上(含)之連署提名、校務會議代表 10 人以上(含)之連署提名,推薦曾任國內外大學校長、學術成就傑出、熟悉大學 事務或關心本大學發展之社會公正人士若干人。 2. 推選或推薦代表時,任一性別應占 1/3 以上。 3. 本校現職專任人員,不得被提名為校友代表及社會公正人士代表。 研究成果目錄: 論文及著述(五年內:2002-2007) 1. Liu C.-Y., Hong C.-J., Liu T.-Y., Lin K.-N., Wang P.-N., Chi C.-W., Chuang Y.-Y., and Liu H.-C. (2002) Lack of association between the apoE genotype and depression in Alzheimer’s disease. J. Geriatric Psychiatry and Neurology: 15: 20-23. 2. Chiu E.-J., Lin H.-L., Chi C.-W., Liu T.-Y., and Lui W.-Y. (2002) Estrogen therapy for hepatectomy patients with poor liver function? Medical Hypotheses 58: 516-518. 3. Chen C. -L., Chi -C. -W., and T. -Y. Liu (2002) Hydroxy radical formation and oxidative DNA damage induced by areca quid in vivo J Toxicol Environ Health (Part A) 65: 327-336. 4. Lui W.-Y., Chi C.-W.*, Chang Y.-F., Chu H.-W., Hsieh C.-C., Yin P.-H., Liu T.-Y., Ou Y.-R., and P’eng F.-K. (2002) In vivo and in vitro growth stimulation of murine hepatoma cells by glucocorticoid. Anticancer Research 22: 1413-1422. 5. Wang J.-J., Chern Y.-T., Chang Y.-F., Liu T.-Y., and Chi C.-W.* (2002) Dimethyladmantyl-maleimide induced in vitro and in vivo growth inhibition of human colon cancer Colo205 cells. Anticancer Drugs 13: 533-543. 6. Lin W.-Y., Chi, C.-W., Ho Y.-J., Wu I.-C., Chung Y.-T., Chen S.-D., Chou F.-I., Kai J.-J., Lui W.-Y., Chen T.-J., and Lin YC. (2002) Boron-lipiodol: a potential new drug for the treatment of liver tumors. Anticancer Research 22: 3989-3992. 7. Wu C.-W., Chen G.-D., Fann C S.-J., Lee A F.-Y., Chi C.-W., Liu J. M., Weier U., and Chen J.-Y. (2002) Clinical implications of chromosomal abnormalities in gastric adenocarcinoma. Genes Chromosomes and Cancer 35: 219-231. 8. Wu C.-W., Chi C.-W., and Lin W.-c (2002) Gastric cancer: prognostic and diagnostic advances. Exp. Rev. Mol. Med. 21 March, http://www-ermm.cbcu.cam.ac.uk/02004337h.htm. 9. Wu C.-W., Lee A F.-Y., Chi C.-W., Lai C.-H., Huang C.-L., Lo S.-S., Lui W.-Y., and Lin W.-c (2002) Clinical significance of AXL kinase family in gastric cancer. Anticancer Research 22: 1071-1078. 10. Tsai D.-C., Hsu W.-M., Chou C.-K., Chen S.-J., Peng C.-H., Chi C.-W., Ho L.-L., Liu J.-H., Chiou S.-H. (2002) Significant variation of the elevated nitric oxide levels in aqueous humor from patients with different types of glaucoma. Ophthalmologica. 216:346-350. 11. Lee, H.C., Yin, P.H., Chi, C.W., Wei, Y.H. (2002) Increase of mitochondrial mass in human fibroblasts under oxidative stress and during replicative cell senescence. J. Biomed. Sci., 9, 517-526. 12. Lin H.-L, WY Lui W.-Y., TY Liu T.-Y., Chi C.-W.* (2003) Reversal of Taxol-resistance in hepatoma by cyclosporin A : involvement of the PI-3 kinase-AKT 1 pathway. British J Cancer 88:973-980. 13. Tsou A.-P., Yang C.-W., Huang C.-Y. F., Yu R. C.-T., Lee Y.-C. G., Chang C.-W., Chen B.-R., Chung Y.-F., Fann M.-J., Chi C.-W., Chiu J.-H., and Chou C.-K (2003) Identification of a novel cell cycle regulated gene, HURP, overexpressed in human hepatocellular carcinoma. Oncogene 22: 298-307. 14. Wu C.-W., Li A.-F., Chi C.-W., Huang C.-J., Huang C.-L., Lui W.-Y., Lin W.-C. (2003) Arg tyrosine kinase expression in human gastric adenocarcinoma is associated with vessel invasion. Anticancer Res. 23(1A):205-210. 15. Yang D.-M., Huang C.-C., Lin H.-Y., Tsai D.-P., Kao L.-S., Chi C.-W., Lin C.-C. (2003) Tracking of secretory vesicles of PC12 cells by total internal reflection fluorescence microscopy. J Microsc. 209(Pt 3):223-227. 16. Tang D.-W., Lin S.-C., Chang K.-W., Chi C.-W., Chang C.-S., and Liu T.-Y. (2003) Elevated expression of cyclooxygenase (COX)-2 in oral squamous cell carcinoma-evidence for COX-2 induction by areca quid ingredients in oral keratinocytes. J Oral Pathol Med 32: 522-529. 17. Chou F.-I., Chung H.-P., Shieh M.-S., Huang C.-W., Chung R.-J., Liu H.-M., Yang J.-Y., Chi C.-W., Lin Y.-C., Lui W.-Y., and Kai J.-J.(2003) Synthesis and in vitro evaluation of the phenylboric acid derivative entrapped lipiodol in neutron capture therapy for hepatoma. Anticancer Research 23: 3955-3964. 18. Wang J.-J., Chang Y.-F., Chern Y.-T., and Chi C.-W.. (2003) Study of the in vitro and in vivo effects of 1,6-bis[4-(4-amino-3-hydroxyphenoxy)phenyl]diamantane (DPD), a novel cytostatic and differentiation inducing agent, on human colon cancer cells. British J Cancer 89:1995-2003. 19. Chen J.-Y., Chi C.-W., Chen H.-L., Wan C.-P., Yang W.-C. and Yang A.-H. (2003) TNF- renders human peritoneal mesothelial cells sensitive to anti-Fas antibody-induced apoptosis. Nephrol Dial Transplant 18: 1741-1747. 20. Kuo C.-L., Chi C.-W., and Liu T.-Y. (2004) The anti-inflammatory potential of berberine in vitro and in vivo. Cancer Lett 203: 127-137. 21. Yin P.-H., Lee H.-C., Chau G.-Y., Wu Y.-T., Li S.-H., Lui W.-Y., Wei Y.-H., Liu T.-Y., Chi C.-W.* (2004) Alteration of the copy number and deletion of mitochondrial DNA in human hepatocellular carcinoma. British J Cancer 90: 2390-2396. 22. Liu, T, Y., Chung, Y.T., Wang, P.F., Chi, C.W., and Hsieh, L.L., (2004) Safrole-DNA adducts in human peripheral blood - an association with areca quid chewing and CYP2E1 polymorphisms. Mutat Res 559:59-66. 23. Lee, S-M., Tseng, L-M., Li, A.F., Liu, H.C., Liu, T.Y., and Chi, C.W.* (2004) Polymorphism of estrogen metabolism genes and cataract. Med. Hypo 63: 494-497. 24. Ko, S.Y., Lin, S.C., Chang, K.W., Wong, Y.K., Liu, C.J., Chi, C. W. and Liu, T.Y. (2004) Increased expression of amyloid precursor protein (APP) in oral squamous cell carcinoma. Int. J. Cancer 111: 727-732. 25. Yin P. H, Lee H. C., Chau G.-Y., Liu T.-Y., Liu H.-C., Lui W.-Y. and Chi C.-W.* (2004) Polymorphisms of estrogen-metabolizing genes and risk of hepatocellular carcinoma in Taiwan females. Cancer Lett. 212:195-201. 26. Liu, C.-A., Wang, M.-J., Chi, C.-W., Wu, C.-W., and Chen, J.-Y. (2004) Overexpression of rho effector rhotekin confers increased survival in gastric adenocarcinoma. J. Biomed. Sci. 11: 661-670. 27. Liu, C.-A., Wang, M.-J., Chi, C.-W., Wu, C.-W., and Chen, J.-Y. (2004) Rho/Rhotekin-mediated NF-B activation confers resistance to apoptosis. Oncogene 23:8731-8742. 28. Tang D.-W., Chang K.-W., Chi C.-W., and Liu T.-Y. (2004) Hydroxychavicol modulates benzo[a]pyrene-induced genotoxicity through induction of dihydrodiol dehydrogenase. Toxicology Letters 152: 235-243. 29. Hsu W.-M., Chiou S.-H., Chen S. S.-L., Shyong M.-P., Ho C.-K., Chen S.-J., Wu C.-C., Kung S.-H., and Chi C.-W. (2004) The HIV RNA levels of plasma and ocular fluids in AIDS patients with ophthalmic infections. Ophthalmologica 218: 328-332. 30. Chang J.-B., Wang P.-N., Chen W.-T., Lin C.-Y., Hong C.-J., Lin K.-N., Liu T.-Y., Chi C.-W., and Liu H.-C. (2004) ApoE e4 allele is associated with incidental hallucinations and delusions in patients with AD. Neurology 63: 1105-1107. 31. Wu C.-W., Chi C.-W. and Huang T.-S. (2004) Elevated level of spindle checkpoint MAD2 correlates with cellular mitotic arrest, but not with aneuploidy and clinicopathological characteristics in gastric cancer. World J. Gastroenterol 10: 3240-3244. 32. Wang S.-Y., Wang H.-H., Chi C.-W., Chen C.-F. and Liao J.-F. (2004) Effects of baicalein on -amyloid peptide-(25-35)-induced amnesia in mice. European J Pharmacology 506: 55-61. 33. Wang J.-J., Chen Y.-C., Chi C.-W., Huang K.-T., and Chern Y.-T. (2004) In vitro and in vivo growth inhibition and G1 arrest in human cancer cell lines by diaminophenyladamantane derivatives. Anti-Cancer Drugs 15: 697-705. 34. Chang Y.-F., Chi C.-W., Chern Y.-T., and Wang J.-J. (2005) Effects of 1,6-bis[4-(4-amino-3-hydroxyphenoxy)phenyl]diamantane (DPD), a reactive oxygen species and apoptosis inducing agent, on human leukemia cells in vitro and in vivo. Toxicology and Applied Pharmacology 202: 1-12. (equal contribution as first author) 35. Chou F.-I., Hsieh M.-F. Chung R.-J., Liu H.-S., Chin T.-S., Lui W.-Y., Chi C.-W., and Liu R.-S. (2005) Preparation and in vitro evaluation of radiactive calcium-phosphate micron-sized particled for internal radiotherapy of hepatoma. Key Engineering Materials 284-286: 859-862. 36. Wang P. N., Liu H.C., Liu T.Y., Chu A., Hong C. J., Lin K.N., Chi C.-W.* (2005) Estrogen metabolizing gene COMT polymorphism synergistic APOE epsilon4 allele increase the risk of Alzheimer disease. Dementia and Geriatric Cognitive Disorders 19:120-125. 37. Liu H.C., Hong C. J., Liu T.Y., Chi C.-W., and Tsai S.-J. (2005) Association analysis for the muscarinic M1 receptor genetic polymorphisms and Alzheimer’s disease. Dementia and Geriatric Cognitive Disorders 19:42-45. 38. Wu C.-W., Yin P.-H., Hung W.-Y., Li A. F.-Y., Li S.-H., Chi C.-W., Wei Y.-H., and Lee H.-C. (2005) Mitochondrial DNA mutations and mitochondrial DNA depletion in gastric cancer. Genes Chromosome and Cancer 44:19-28. 39. Liu H.C., Chi C.-W., Ko S.-Y., Wang H.-C., Hong C. J., Lin K.-N., Wang P.-N., and Liu T.Y. (2005) Cholinesterase inhibitor affects the amyloid precursor protein isoforms in patients with Alzheimer’s disease. Dementia and Geriatric Cognitive Disorders 19:345-348. 40. Kuo C.-L., Chi C.-W., and Liu T.-Y. (2005) Modulation of apoptosis by berberine through inhibition of cyclooxygenase-2 and Mcl-1 expression in oral cancer cells. In Vivo 19: 247-252. 41. Lee H.-C., Yin P.-H., Lin J.-C., Wu C.-C., Chen C.-Y., Wu C.-W., Chi C.-W., Tam T.-N., and Wei Y.-H. (2005) Mitochondrial genome instability and mtDNA depletion in human cancers. Ann N.Y. Acad. Sci 1042: 109-122. 42. Lo S.-S., Wu C.-W., Chi C.-W., Li A.-F., Chen J.-H. and Lui W.-Y. (2005) High CD40 expression in gastric cancer associated with expanding type histology and liver metastasis. Hepatogastroenterology. 52:1902-1904. 43. Wu C.-W., Kao H.-L., Li A.-F., Chi C.-W. and Lin W.-C. (2005) Protein tyrosine-phosphatase expression profiling in gastric cancer tissues. Cancer Lett. 242:95-103. 44. Yang D.-M., Lin C.-C., Lin H.-Y., Huang C.-C., Tsai D.-P., Chi C.-W. and Kao L.-S. (2005) Dynamics of mitochondria and mitochondrial Ca 2+ near the plasma membrane of PC12 cells. A study by multimode microscopy. Ann N.Y. Acad. Sci 1042; 163-167. 45. Wu H.-J. Chi C.-W. and Liu T.-Y. (2005) Effects of pH on nicotine-induced DNA damage and oxidative stress. J. Toxicology Environmental Health, Part A, 68:1511–1523. 46. Chen J.-H., Wu C.-W., Kao H.-L., Chang H.-M., Li Anna F.-Y., Liu T.-Y., and Chi C.-W., Li A.-F.,. and CHI C.-W.* (2006) Effects of COX-2 inhibitor on growth of human gastric cancer cells and its relation to hepatocyte growth factor. Cancer letters 239: 263-270. 47. Wu C.-W., Chen J.-H., Kao H.-L., Li A.-F., Lai C.-H., Chi C.-W. and Lin W.-C. (2006) PTPN3 and PTPN4 tyrosine phosphatase expression in human gastric adenocarcinoma. Anticancer Res. 26(2B):1643-9. 48. Ping Y.-H., Lee H.-C., Lee J.-Y., Wu P.-H., Ho L.-K., Chi C.-W., Lu M.-F. and Wang J.-J. (2006) Anticancer effects of low-dose 10-hydroxycamptothecin in human colon cancer. Oncol Rep. 15:1273-9. 49. Kung S.-P., Lee C.-H., Yang A.-H., Chi C.-W., Tseng L.-M. and Wu C.-W. (2006) Expression of c-kit, Flk-1, and Flk-2 receptors in benign and malignant tumors of follicular epithelial origin. J Chin Med Assoc.69:74-79. 50. Tseng L.-M., Yin P.-H., Chi C.-W., Hsu C.-Y., Wu C.-W., Lee L.-M., Wei Y.-H. and Lee H.-C. (2006) Mitochondrial DNA mutations and mitochondrial DNA depletion in breast cancer. Genes Chromosomes Cancer. 45:629-638. 51. Wang J.-Y., Chuang H.-N., Chiu J.-H., Fu S.-L., Tsai T.-H., Tsou A.-P., Hu C.-P., Chi C.-W., Yeh S.-F.,, Lui W.-Y., Wu C.-W. and Chou C.-K. (2006) Effects of Scutellaria baicalensis Georgi on macrophage-hepatocyte interaction through cytokines related to growth control of murine hepatocytes. Exp Biol Med (Maywood). 231:444-455. 52. Wang J.-J., Lee J.-Y., Chen Y.-C., Chern Y.-T. and Chi C.-W.*. (2006) The antitumor effect of a novel differentiation inducer, 2, 2-Bis (4-(4-amino-3-hydroxyphenoxy) phenyl) adamantane (DPA), in combinatory therapy on human colon cancer. Int J Oncol. 28:1003-1012. 53. Chang P.-C., Chi C.-W., Chau G.-Y., Li F.-Y., Tsai Y.-H., Wu J.-C. and Wu Lee Y.-H. (2006) DDX3, a DEAD box RNA helicase, is deregulated in hepatitis virus-associated hepatocellular carcinoma and is involved in cell growth control. Oncogene. 30;25:1991-2003. 54. Hsu L.-S., Lee H.-C., Chau G.-Y., Yin P.-H., Chi C.-W. and Lui W.-Y. (2006) Aberrant methylation of EDNRB and p16 genes in hepatocellular carcinoma (HCC) in Taiwan. Oncol Rep. 15:507-511. 55. Chang S.-C., Lin J.-K., Yang S.- H., Li Anna F.-Y. and Chi C.-W*. (2006) Relationship between genetic alterations and prognosis in sporadic colorectal cancer. International J. Cancer 118:1721-1727. 56. Chang Y.-F. Chi C.-W. and Wang J.-J. (2006) Reactive oxygen species production is involved in quercetin-induced apoptosis in human hepatoma cells. Nutr Cancer. 55:201-209. 57. Wu P.-H., Shen Y.-C., Wang Y.-H., Chi C.-W., and Yen J.-C. (2006) Baicalein attenuates methamphetamine-induced loss of dopamine transporter in mouse striatum. Toxicology. 226:238-245. 58. Liu Y.-Y., Yeh P.-H., Wang G.-J., Huang S.-W., Chi C.-W., Ho L.-K., and Pan W H.-T. (2006) Baicalein reverses the methamphetamine-induced striatal dopaminergic neurotoxicity in mice. J Food and Drug Analysis 14: 317-322. 59. Lee J.-L., Wang M.-J., Sudhir P.-R., Chen G.-D., Chi C.-W., and Chen J.-Y. (2007) Osteopontin promotes integrin activation through outside-in and inside-out mechanisms: OPN-CD44V interaction enhances survival in gastrointestinal cancer cells. Cancer Research 67: 2089-2097. 60. Hsia C.-Y., Huo T.-I., Chiang S.-Y., Lu M.-F., Sun C.-L., Wu J.-C., Lee P.-C., Chi C.-W. Chi, Lui W.-Y., Lee S.-D. (2007) Evaluation of interleukin-6, interleukin-10 and human hepatocyte growth factor as tumor markers for hepatocellular carcinoma. Eur J Surg Oncol 33: 208-212. 61. Luo J.-C., Chi C.-W., Lin H.-Y., Chang F.-Y., Lu C.-L., Chen C.-Y., Lee S.-D. (2007) Dexamethasone inhibits epidermal growth factor-stimulated gastric epithelial cell proliferation. J Pharmacol and Exp Ther 320:687-694. 62. Liu H.-C., Wang H.-C., Ko S.-Y., Wang P.-N., Chi C.-W., Hong C.-J., Lin K.-N., and Liu T.-Y. (2007) Correlation between platelet amylodi precursor protein isoform ration and cognition in Alzheimer’s disease. J Alzheimer’s Disease 11: 77-84. 63. Yang M.-H., Chang S.-Y., Chiou S.-H., Liu C.-J., Chi C.-W., Chen P.-M., Teng S.-C., and Wu K.-J. (2006) Overexpression of NBS1 induces epithelial-mesenchymal transition and co-expression of NBS1 and Snail predicts metastasis of head and neck cancer. Oncogene. 2006 Aug 28; [Epub ahead of print] 64. Lee H.-C., Hsu L.-S., Yin P.-H., Lee L.-M., and Chi C.-W. (2007) Heteroplasmic mutation of mitochondrial DNA D-loop and 4977-bp deletion in human cancer cells during mitochondrial DNA depletion. Mitochondrion. 7(1-2):157-63. Epub 2006 Dec 8. 65. Chau G.-Y., Lui W.-Y., Chi C.-W., Chau Y.-P., Li A.-F., Kao H.-L., and Wu C.-W. (2007) Significance of serum hepatocyte growth factor levels in patients with hepatocellular carcinoma undergoing hepatic resection. 2007 January 9; [Epub ahead of print]. 66. Hsieh Y.-J., Ke C.-C., Liu R.-S., Wang F.-H., Tang K.-T., Chi C.-W., Chen F.-D. and Lee C.-H. (2007) Radioiodide imaging and treatment of ARO cancer xenograft in a mouse model after expression of human sodium iodide symporter. Anticancer Res. 27(4B):2515-22. 67. Wu J.-W., Lin L.-C., Hung S.-C., Chi C.-W. and Tsai T.-H. (2007) Analysis of silibinin in rat plasma and bile for hepatobiliary excretion and oral bioavailability application. J Pharm Biomed Anal. 2007 Jul 7 [Epub ahead of print] 68. Lin H.-L., Yang M.-H., Wu C.-W., Chen P.-M., Yang Y.-P., Chu Y.-R., Kao C.-L., Ku H.-H., Lo J.-F., Liou J.-P., Chi C.-W. and Chiou S.-H. (2007) 2-Methoxyestradiol attenuates phosphatidylinositol 3-kinase/Akt pathway-mediated metastasis of gastric cancer. Int J Cancer. 2007 Aug 6; [Epub ahead of print] 69. Wang Y.-W., Huo T.-I., Yang Y.-Y., Hou M.-C., Lee P.-C., Lin H.-C., Lee F.-Y., Chi C.-W. and Lee S.-D. (2007) Correlation and comparison of the model for end-stage liver disease, portal pressure, and serum sodium for outcome prediction in patients with liver cirrhosis. J Clin Gastroenterol. 2007 Aug;41(7):706-12. 70. Lin H.-L., Chiou S-H., Wu C.-W., Lin W-B., Chen L.-H., Yang Y.-P., Tsai M.-L., Uen Y.-H., Liou J.-P. and Chi C.-W. (2007) Combretastatin A4-Induced Differential Cytotoxicity and Reduced Metastatic Ability by Inhibition of AKT Function in Human Gastric Cancer Cells. J Pharmacol Exp Ther. 2007 Jul 23; [Epub ahead of print] 71. Huo T.-.I, Lin H.-C., Hsia C.-Y., Wu J.-C., Lee P.-C., Chi C.-W. and Lee S.-D. (2007) The model for end-stage liver disease based cancer staging systems are better prognostic models for hepatocellular carcinoma: a prospective sequential survey. Am J Gastroenterol. 102(9):1920-30. Epub 2007 Jun 15. 72. Huo T.-I., Hsia C.Y-, Chu C.-J., Huang Y.-H., Lui W.-Y., Wu J.-C., Lee P.-C., Chi C.-W. and Lee S.-D. (2007) The predictive ability of serum alpha-fetoprotein for hepatocellular carcinoma is linked with the characteristics of the target population at surveillance. J Surg Oncol. 95(8):645-51. 73. Huo T.-I., Huang Y.-H., Chiang J.-H., Wu J.-C., Lee P.-C., Chi C.-W. and Lee S.-D. (2007) Survival impact of delayed treatment in patients with hepatocellular carcinoma undergoing locoregional therapy: is there a lead-time bias? Scand J Gastroenterol. 42(4):485-92. 74. Wu C.-W., Ping Y.-H., Yen J.-C., Chang C.-Y., Wang S.-F., Yeh C.-L., Chi C.-W. and Lee H.-C. (2007) Enhanced oxidative stress and aberrant mitochondrial biogenesis in human neuroblastoma SH-SY5Y cells during methamphetamine induced apoptosis. Toxicol Appl Pharmacol. 220(3):243-51. Epub 2007 Feb 7. (Chi C.-W.* indicate corresponding author) 專利: 1. NEW USE OF DOCETAXEL FOR TREATING HEPATOMA. Patent number WO0115675; Publication date 2001-03-08 2. USE OF DOCETAXEL FOR TREATING HEPATOCELLULAR CARCINOMA. Patent number CA2382294; Publication date 2001-03-08 3. Pharmaceutical preparation intended for treating hepatocellular carcinoma. Patent number CZ20020739; Publication date 2002-06-12 4. New use of docetaxel for treating hepatoma. Patent number CN1372466; Publication date 2002-10-02 5. 6. 7. 8. 9. 10. 11. 12. 13. USE OF DOCETAXEL FOR TREATING HEPATOCELLULAR CARCINOMA.Patent number. EP1214061; Publication date 2002-06-19 Use of docetaxel for treating hepatoma. Patent number US2003158249; Publication date 2003-08-21 Use of docetaxel for treating hepatoma. Patent number EE200200087; Publication date 2003-04-15 Use of docetaxel for treating hepatoma. Patent number JP2003508427T; Publication date 2003-03-04 VERWENDUNG VON DOCETAXEL FÜR DIE BEHANDLUNG VON HEPATOZELLULÄRE KREBS. Patent number AT269700T; Publication date 2004-07-15 NOVA UTILIZACAO DE DOCETAXEL PARA O TRATAMENTO DO CARCINOMA HEPATOCELULAR. Patent number PT1214061T. Publication date 2004-09-30 USE OF DOCETAXEL FOR TREATING HEPATOCELLULAR CARCINOMA. Patent number SI1214061T; Publication date 2004-12-31 New use of docetaxel for treating hepatoma. Patent number TW589180;Publication date 2004-06-01 林文昌,黃銓珍, 吳秋文, 戚謹文, 張久瑗, 常蘭陽. 2004. 診斷及治療胃癌 之方法. 中華民國發明專利. 中華民國證書號數: 發明第 1224623 號. 2004/12/01~ 2021/2/22