Yu Liang, Ph.D.
850 Lincoln Centre Drive, Foster City, CA 94404
(650) 638-5049
Yu.Liang@lifetech.com
QUALIFICATIONS
Education:
1986-1990
1993-1999
B.Sc., Department of Plant Pathology and Entomology, National Taiwan University, Taipei, Taiwan
Ph.D., Department of Pharmacology, New York University, School of Medicine, New York, USA
Certificate:
1999
2008
Bioinformatics, Functional genomics, and Proteomics (University of California, Davis)
DOORS®: Requirements Management for Complex Systems and Software Development (Telelogic, IBM)
Awards and Honors:
1990
Book Coupon Award (Summa Cum Laude graduate), National Taiwan University
1993-1999
Pre-doctoral Fellowship, Sackler Institute of Graduate Biomedical Sciences, New York University Medical Center
1996
GSAS Travel Award, New York University (the 6th International Congress on Cell Biology and 36th ASCB Annual
Meeting)
1998 Mar
Sackler Institute Travel Award, New York University Medical Center (the 39th Annual Drosophila Research
Conference)
1998 Oct
Sackler Institute Travel Award, New York University Medical Center (the 2nd Conference on the Prospects for
Neural Transplantation, Gene Therapy and Progenitor Cell Biology)
2006-2008
Demonstrated Noteworthy Achievement Award, Applera Corporation (for successfully achieving company’s
financial goals and product delivery).
Ad hoc reviewer:
2002-2005
2004-2005
2006
2007
2008
2009
Cancer Research
Clinical Cancer Research
Anti-Cancer Drugs
Gene Regulation and Systems Biology
Laboratory Investigation, Cancer Informatics, BMC Cancer, PLoS ONE, Journal of Cellular and Molecular
Medicine
BMC Genomics, Journal of Cellular and Molecular Medicine, Expert Review of Respiratory Medicine
Professional Activities:
1996-1997
Member, American Society for Cell Biology
2004-present
Member, American Association for Cancer Research
2007-present
Editorial Board, TechNotes, Ambion/Applied Biosystems
PROFESSIONAL EXPERIENCE
1989-1990
1992-1993
1993-1999
1999-2001
2001-2005
2005-present
Undergraduate Research Fellow, Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan.
Research Assistant, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Pre-doctoral Research fellow, Sackler Institute of Graduate Biomedical Sciences, Department of Pharmacology,
New York University School of Medicine.
Postdoctoral Fellow, Preuss Laboratory for Molecular Neuro-Oncology, Department of Neurological Surgery,
University of California, San Francisco.
Assistant Researcher, Brain Tumor Research Center, Department of Neurological Surgery, University of California,
San Francisco.
Staff Scientist, Genomic Assays-R&D, Life Technologies (former Applied Biosystems), Foster City, CA, USA.
PUBLICATIONS
1.
2.
Chern Y, Lai HL, Fong JC, Liang Y. Multiple mechanisms for desensitization of A2a adenosine receptor-mediated cAMP
elevation in rat pheochromocytoma PC12 cells. Molecular Pharmacology (1993) 44:950-958. (PMID: 8246918)
Su YC, Kao LS, Liang Y, Tsai MH, Chern Y. Expression of a small molecular weight GTP-binding, Rab3C, in rat
pheochromocytoma PC12 cells. Molecular Biology of the Cell (1993) 4:236a.
Page 1 of 2
3.
Chen LM, Liang Y, Tai JH, Chern Y. Comparison of nitrocellulose and PVDF membranes in GTP-overlay assay and Western blot
analysis. Biotechniques (1994) 16:600-601. (PMID: 8024776)
4. Su YC, Kao LS, Chu YY, Liang Y, Tsai MH, Chern Y. Distribution and regulation of Rab3C, a small molecular weight GTPbinding protein. Biochemical and Biophysical Research Communications (1994) 200:1257-1263. (PMID: 8185573)
5. Liang Y and Margolis RU Expression pattern and functional effects of glypican in nervous tissue. Molecular Biology of the Cell
(1996) 7:236a.
6. Liang Y, Häring M, Roughley PJ, Margolis RK, Margolis RU. Glypican and biglycan in the nuclei of neurons and glioma cells:
presence of functional nuclear localization signals and dynamic changes in glypican during the cell cycle. Journal of Cell Biology
(1997) 17:851-864. (PMID: 9362504)
7. Liang Y, Annan RS, Carr SA, Popp S, Mevissen M, Margolis RU, Margolis RU. Mammalian homologues of the Drosophila Slit
protein are ligands of the heparan sulfate proteoglycan glypican in brain. Journal of Biological Chemistry (1999) 274:1788517892. (PMID: 10364234)
8. Hu Z, Bonifas JM, Aragon G, Kopelovich L, Liang Y, Ohta S, Israel MA, Bickers D, Aszterbaum M, Epstein EH Jr. Evidence for
lack of enhanced hedgehog target gene expression in common extracutaneous tumors. Cancer Research (2003) 63:923-928.
9. Oshio K, Binder DK, Liang Y, Bollen AW, Feuerstein BG, Berger MS, Manley GT. Expression of the aquaporin-1 water channel
in human glial tumors. Neurosurgery (2005) 56:375-381. (PMID: 15670385)
10. Liang Y, Diehn M, Watson N, Bollen AW, Aldape KD, Lamborn KR, Nicholas MK, Berger MS, Botstein D, Brown PO, Israel
MA. Gene expression profiling reveals clinically distinct subtypes of glioblastoma multiforme. Proceedings of the National
Academy of Sciences, USA (2005) 102: 5814-5819. (PMID: 15827123)
11. Liang Y*, Bollen AW, Nicholas MK, Gupta, N. Id4 and FABP7 are preferentially expressed in cells with astrocytic features in
oligodendroglial and oligoastrocytic tumors. BMC Clinical Pathology (2005) 5:6. (PMID: 16018821)
12. Liang Y*, Bollen AW, Aldape KD, Gupta N. Nuclear FABP7 immunoreactivity is preferentially expressed in infiltrative glioma
and is associated with poor prognosis in EGFR-overexpressing glioblastoma. BMC Cancer (2006) 6:97. (PMID: 16623952)
13. Gaur AB, Jewell DA, Liang Y, Ridzon D, Moore JH, Chen C, Ambros VR, Israel MA. Characterization of microRNA expression
levels and their biological correlates in human cancer cell lines. Cancer Research (2007) 67:2456. (PMID: 17363563)
14. Liang Y*, Ridzon D, Wong L, Chen C. Characterization of microRNA expression profiles in normal human tissues. BMC
Genomics (2007) 8:166. (PMID: 17565689)
15. He L, He X, Lim LP, de Stanchina E, Xuan Z, Liang Y, Xue W, Zender L, Magnus J, Ridzon D, Jackson AL, Linsley PS, Chen C,
Lowe SW, Cleary MA, Hannon GJ. A microRNA component of the p53 tumour suppressor network. Nature (2007) 447:1130.
(PMID: 17554337)
16. Liang Y*, Diehn M, Bollen AW, Israel MA, Gupta, N. Type I collagen is overexpressed in medulloblastoma as a component of
tumor microenvironment. Journal of Neuro-Oncology (2008) 86:133. (PMID: 17653508)
17. Liang Y*, Bollen AW, Gupta N. CC chemokine receptor-2A is frequently overexpressed in glioblastoma. Journal of NeuroOncology (2008) 86:153. (PMID: 17703277)
18. Diehn M, Nardini C, Wang DS, McGovern S, Jayaraman M, Liang Y, Aldape K, Cha S, Kuo MD. Identification of non-invasive
imaging surrogates for brain tumor gene expression modules. Proceedings of the National Academy of Sciences, USA (2008)
105: 5213-5218. (PMID: 18362333)
19. Fan AC, Goldrick MM, Ho J, Liang Y, Bachireddy P, Felsher DW. A quantitative PCR method to detect blood microRNAs
associated with tumorigenesis in transgenic mice. Molecular Cancer (2008) 7:74. (PMID: 18826639)
20. Liang Y*. An expression meta-analysis of predicted microRNA targets identifies a diagnostic signature for lung cancer. BMC
Medical Genomics (2008) 1:61. (PMID: 19087325)
21. Cheng A, Li M, Liang Y, Wang Y, Wong L, Chen C, Vlassov AV, Magdaleno S. Stem-loop RT-PCR quantification of siRNAs in
vitro and in vivo. Oligonucleotides (2009) 19:203. (PMID: 19284311).
*Corresponding author.
BOOK CHAPTER/REVIEW



Liang Y, Wong L, Tan R, Chen C. (2008) Real-time quantification of microRNAs by TaqMan® assays, p.269-282, in
MicroRNAs: From Basics Science to Disease Biology. Editor: Appasani K. Cambridge, Cambridge University Press.
Liang Y, Russell I, Walworth C, Chen C. Gene Expression in Stem Cells. Critical Reviews in Eukaryotic Gene Expression
(2009) (in press).
Invited reviewer for e-book proposal published by Bentham Science Publishers: Computational Biology of Embryonic Stem
Cells by Dr. Ming Zhan (2009).
Page 2 of 2