Kurt L. Fredrick
Department of Microbiology, The Ohio State University
484 West 12th Avenue, Columbus, Ohio 43210
Phone: 614-292-6679; Fax: 614-292-8120; e-mail: fredrick.5@osu.edu
POSITIONS AND EMPLOYMENT
2009-present
Associate Professor, Department of Microbiology, Ohio State University,
Columbus, OH
2003-2009
Assistant Professor, Department of Microbiology, Ohio State University,
Columbus, OH
2003-present
Member, Ohio State Biochemistry Program (OSBP)
2003-present
Member, Center for RNA Biology, Ohio State University
EDUCATION AND TRAINING
1988-1992
B.A. Biology, Gustavus Adolphus College, St. Peter, MN
Advisor: Prof. Colleen Jacks
1992-1997
Ph.D. Microbiology, Cornell University, Ithaca, NY
Advisor: Prof. John D. Helmann
1998-2003
Postdoctoral Research, University of California, Santa Cruz, CA
Advisor: Prof. Harry F. Noller
HONORS AND AWARDS
1988-1992
1991
1993-1994
1998-2001
2004
Andrew Thorson Scholarship, Gustavus Adolphus College, St. Peter, MN
Winter-term Research Fellowship, University of Arizona, Tucson, AZ
NIH Biotechnology Training Grant, Cornell University, Ithaca, NY
NIH Postdoctoral Fellowship, University of California, Santa Cruz, CA
Nominee for Packard Foundation Fellowship for Science and
Engineering, Office of Research, Ohio State University
RESEARCH INTERESTS
My group is interested in understanding how the ribosome works. The ribosome is a 2.5 MDa
RNA-based machine that translates the genetic code in all organisms. In the last decade,
numerous structures of the ribosome and various ribosomal complexes have been solved by xray crystallography and cryo-electron microscopy. A primary challenge in the field today is to
define the molecular mechanisms that underline protein synthesis in structural terms. To date,
much of our effort has focused on translocation, the coupled movement of tRNA and mRNA in
the ribosome, a reaction catalyzed by EF-G and GTP. Work from our group has provided
insight regarding both the thermodynamics and kinetics of tRNA movement within the
ribosome and the mode of action of several translocation inhibitors. While our studies on
translocation will continue, we have expanded our efforts to investigate other steps in protein
CURRICULUM VITAE
KURT FREDRICK
synthesis. Recently, we have isolated and begun to characterize a number of 16S rRNA
mutations that confer specific defects in initiation, elongation, and/or termination.
PROFESSIONAL SERVICE
Grant reviewing
2005-present
2006-present
2009
2010
Ad hoc reviewer, National Science Foundation
Member, National Science Foundation Prokaryotic Biology Review Panel
Ad hoc member, National Institutes of Health Special Emphasis Study
Section (GCAT)
Ad hoc member, National Institutes of Health MGA Study Section
Manuscript reviewing
2003-present
Journals:
Archives of Microbiology
Biochemistry
Biopolymers
Cell
Cellular and Molecular Life Sciences
EMBO Journal
EMBO Reports
FEBS Letters
Gene
Journal of Bacteriology
Journal of Molecular Biology
Molecular Cell
Molecular Microbiology
Nature
Nature Structural and Molecular Biology
Nucleic Acids Research
Proceedings of the National Academy of Sciences USA
RNA
Science
Trends in Biochemical Sciences
Trends in Microbiology
Tuberculosis
Other professional service
2009-present
Member, Nominating Committee for the RNA Society
ADMINISTRATIVE SERVICE
Department of Microbiology
2003-2005
Member, Undergraduate Curriculum Committee
2005-present
Undergraduate Research Coordinator
2007-present
Organizer, Annual Microbiology Symposium
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CURRICULUM VITAE
2006-2009
2009-present
2009-present
KURT FREDRICK
Member, Graduate Studies Committee
Member, Graduate Studies Advising and Curriculum Committee
Member, Awards Committee
Ohio State Biochemistry Program
2007-present
Member, Recruiting Committee
Other administrative service for the University
2004
Participant, Undergraduate Student Government faculty-student
luncheon
2004-2006
Essay judge, University Scholar Maximus Competition
2004-present
Graduate School representative on graduate exams (1-2 exams/year)
2005
Abstract judge, Hayes Graduate Research Forum
2007
Participant, Graduate and Professional Schools Student Visitation Day
2007-present
Participant, Molecular Life Sciences Interdisciplinary Graduate Programs
Symposium
GRADUATE STUDENTS AND TRAINEES
(All at Ohio State University unless otherwise indicated; OSBP, Ohio State Biochemistry Program)
Doctoral Students (dissertation advisor):
Former
Sarah Walker, Ph.D. Microbiology (2008); Currently employed as a postdoctoral researcher
at Johns Hopkins University (J. Lorsch laboratory).
Shinichiro Shoji, Ph.D. Microbiology (2009); Currently employed as a postdoctoral
researcher at Scripps Research Institute (P. Schultz laboratory).
Current
Daoming Qin, OSBP (6/05-present; Candidacy exam 3/27/07)
Aishwarya Devaraj, OSBP (6/07-present; Candidacy exam 1/23/09)
Sean McClory, OSBP (6/08-present; Candidacy exam 4/5/10)
Rohan Balakrishnan (6/09-present)
Jodie Lee (8/09-present)
Qi Liu (6/10-present)
Masters Students (thesis advisor):
Former
Kevin McGarry, M.S. Microbiology (2007); Currently employed at Battelle.
Doctoral Students (dissertation committee member):
Former
Jen Carr, Ph.D. Biology and Medicine, Brown University, Providence, RI (2005)
Sherry Blight, Ph.D. Microbiology (2006)
Anirban Mahapatra, Ph.D. Microbiology (2007)
Jiqiang Ling, Ph.D. Biochemistry (2008)
Corinne Hausmann, Ph.D. Microbiology (2008)
Dileep Pulukkunat, Ph.D. Biochemistry (2008)
Jessica Wohlgamuth-Benedum, Ph.D. Microbiology (2009)
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CURRICULUM VITAE
KURT FREDRICK
Kirk Gaston, Ph.D. Microbiology (2009)
Ryan Fuchs, Ph.D. Microbiology (2009)
Angela Smith, Ph.D. Microbiology (2009)
Current
Vineeta Kurlekar, Microbiology (1/06-present)
Huanyu Wang, OSBP (2/06-present)
Ruisheng Jiang, OSBP (5/06-present)
Rick Nist, Microbiology (5/06-present)
Shoko Morimoto, Microbiology (9/06-present)
Noah Reynolds, Microbiology (9/06-present)
Theresa Rogers, Microbiology (1/07-present)
Mom Das, OSBP (8/07-present)
Kiley Dare, Microbiology (9/07-present)
Srujana Yadavalli, Microbiology (10/07-present)
Anastasia Sevostiyanova, Microbiology (11/07-present)
Christopher Jones, OSBP (1/08-present)
Hui-Yi Chu, MCDB (6/08-present)
Liang-Chun Liu, Microbiology (8/08-present)
Ran Furman, Microbiology (10/08-present)
Brian Smith, OSBP (1/09-present)
Marla Gilreath, OSBP (1/10-present)
Medha Raina, OSBP (7/10-present)
Masters Students (thesis committee member):
Former
Heather Carter, M.S. Microbiology (2004)
Brian Gabel, M.S. Microbiology (2006)
Yan Chen, M.S. Molecular and Cellular Biochemistry, College of Medicine (2007)
Postdoctoral Fellows
Former
Xiaofen Zhong (2005); Currently employed at University of Central Florida, Orlando, FL.
TEACHING
Classroom teaching (All at Ohio State University)
General Microbiology 1 (Micro 520), lecturer, Sp 04 (50%), Au 04 (100%), Au 05 (100%), Au 06
(100%), Au 07 (100%), Au 08 (100%), Au 09 (100%), Au 10 (100%), undergraduate level.
Advanced Topics in Molecular Microbiology (Micro 760), lecturer, Sp 06 (25%), Sp 08 (25%), Sp
10 (25%), graduate level.
The RNA World (Micro 850), lecturer, Sp 05 (5%), Sp 07 (5%), Au 10 (5%), graduate level.
Nucleic Acids (Biochemp 766), lecturer, Wi 07 (5%), graduate level.
RNA Focus Group (Biochemp 796A), supervisor of seminar course (50%), all quarters 20052009, graduate level.
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CURRICULUM VITAE
KURT FREDRICK
OSBP 1st-2nd year seminar (Biochemp 796, 1 credit hour), supervisor of seminar course (25%),
Au 09, Wi 10, graduate level.
Undergraduate research supervision
Microbiology Research (Micro 699), 2004-present, supervisor (100%), undergraduate level.
Nimo Abdi (2004-2006)
Eric Holbrook (2005-2006)
Daniel Box (2006)
Sabrina Sharif (2007)
Josh Leisring (2008-2009)
Kristina Rached (2009-2010)
PRESENTATIONS
Invited seminars
1999
2002
2002
2002
2003
2003
2004
2005
2005
2006
2006
2008
2009
2009
2010
2010
Department of Biology, University of California, Santa Cruz, CA.
University of Nebraska Medical Center, Omaha, NE.
Department of Biochemistry, University of California, Irvine, CA.
Wadsworth Center, Albany, NY.
Department of Microbiology, Ohio State University, Columbus, OH.
Department of Biochemistry, Molecular Biology, & Biophysics, University of
Minnesota, Minneapolis, MN.
Department of Biology, University of Missouri, St. Louis, MO.
Department of Biochemistry, Ohio State University, Columbus, OH.
Department of Biology, Kenyon College, Gambier, OH.
Department of Microbiology, Miami University, Oxford, OH.
Department of Microbiology, Ohio State University, Columbus, OH.
Department of Microbiology, Ohio State University, Columbus, OH.
Department of Chemistry & Biochemistry, Brigham Young University, Provo,
UT.
Biological Sciences, Columbia University, New York, NY.
Department of Microbiology and Molecular Genetics, Michigan State University,
East Lansing, MI.
Department of Molecular & Cell Biology, University of Connecticut, Storrs, CT.
Talks at scientific meetings
1995
1996
2000
2003
2005
2005
New England Spores Conference, Harvard University, Cambridge, MA.
New England Spores Conference, Harvard University, Cambridge, MA.
RNA 2000 (Fifth Annual Meeting of the RNA Society), University of Wisconsin,
Madison, WI.
Rustbelt RNA Meeting, Mt. Sterling, OH.
Midwest Prokaryotic Molecular Genetics and Physiology Meeting, Bloomington,
IN. (Invited)
Rustbelt RNA Meeting, Mt. Sterling, OH.
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CURRICULUM VITAE
2007
2009
2009
KURT FREDRICK
Ribosomes: Form and function. North Falmouth, MA.
American Society of Microbiology 109th General Meeting, Philadelphia, PA.
(Invited)
Molecular Genetics of Bacteria & Phages, Madison, WI.
Other involvement in scientific meetings (*denotes presenter)
Chen, Y.*, Fredrick, K. and Helmann, J. D. Biochemical studies of the flagellar s factor, D, and
its role in Bacillus subtilis. Molecular genetics of bacteria and phages, Cold Spring
Harbor Laboratories, Cold Spring Harbor, NY, August 24-29, 1993. (poster)
Fredrick, K., Chen, Y. and Helmann, J. D.* Promoter architecture among D-dependent (class
III) flagellar genes in Bacillus subtilis. Bacterial Locomotion and Signal Transduction
(BLAST III), Austin, TX, January 1995. (talk)
Fredrick, K.* and Helmann, J. D. Chemotaxis in Bacillus subtilis requires either of two
functionally redundant CheW homologs. Bacterial Locomotion and Signal Transduction
(BLAST III), Austin, TX, January 1995. (poster)
Fredrick, K.* and Helmann, J. D. Regulation of D activity in B. subtilis. 12th International
Spores Conference, Madison, WI, June 4-8, 1996. (poster)
Helmann, J. D.*, Chen, Y. and K. Fredrick. Transcription initiation by Sigma-D RNA
polymerase. American Society for Microbiology General Meeting, Miami Beach, FL,
May 4-8, 1997. (talk)
Chen, Y.*, Fredrick, K. and Helmann, J. D. Transcription initiation by Bacillus subtilis SigD RNA
polymerase. 17th International Congress of Biochemistry and Molecular Biology and
1997 Annual Meeting of ASBMB, San Francisco, CA, August 24-29, 1997. (poster)
Fredrick, K.* and Noller, H. F. Mapping the functional surface of ribosomal protein S7. RNA
Structure, Santa Cruz, CA, July 12-16, 2000. (poster)
Fredrick, K.* and Noller, H. F. Investigating the functional 30S E site. The Ribosome
(Symposium LXVI), Cold Spring Harbor, NY, May 31-June 5, 2001. (poster)
Fredrick, K.* and Noller, H. F. Sparsomycin induces factor-independent ribosomal
translocation. Ribozymes and RNA Catalysis, Dundee, Scotland, August 23-27, 2002.
(poster)
Qin, D.* and Fredrick, K. Genetic engineering of custom 30S subunit crystals. Rustbelt RNA
Meeting, Mt. Sterling, OH, October 28-29, 2005. (poster)
Walker, S. E.* and Fredrick, K. Recognition and positioning of mRNA by tRNAs with
expanded anticodons in the ribosome. Rustbelt RNA Meeting, Mt. Sterling, OH, October
28-29, 2005. (poster)
Shoji, S., Walker, S. E. and Fredrick, K*. Reverse translocation of tRNA in the ribosome. Nucleic
Acids Gordon Conference, Salve Regina University, Newport, RI, June 4-8, 2006. (poster)
Shoji, S.*, Walker, S. E. and Fredrick, K. Reverse translocation of tRNA in the ribosome. FASEB
Nucleic Acid Enzymes Conference, Saxtons River, VT, June 10-15, 2006. (poster)
Walker, S. E.* and Fredrick, K. Recognition and positioning of mRNA by tRNAs with
expanded anticodons in the ribosome. FASEB Nucleic Acid Enzymes Conference,
Saxtons River, VT, June 10-15, 2006. (talk)
Qin, D.* and Fredrick, K. Characterization of 16S rRNA mutations that decrease the fidelity of
translation initiation. Rustbelt RNA Meeting, Mt. Sterling, OH, October 20-21, 2006.
(poster)
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CURRICULUM VITAE
KURT FREDRICK
Shoji, S.*, Walker, S. E. and Fredrick, K. Reverse translocation of tRNA in the ribosome.
Rustbelt RNA Meeting, Mt. Sterling, OH, October 20-21, 2006. (talk)
Cate, J. H. D.*, Borovinskaya, M. A., Pai, R. D., Zhang, W., Holton, J. M., Kaji, H., Hirokawa, G.,
Kaji, A., Shoji, S. and Fredrick, K. Structural basis for antibiotic inhibition of
translocation and ribosome recycling. Ribosomes: Form and function. North Falmouth,
MA, June 3-8, 2007. (talk)
Qin, D.*, Abdi, N. M. and Fredrick, K. Characterization of 16S rRNA mutations that decrease
the fidelity of translation initiation. Ribosomes: Form and function. North Falmouth,
MA, June 3-8, 2007. (poster)
Shoji, S.*, Borovinskaya, M. A., Cate, J. H. D. and Fredrick, K. Effect of antibiotics on
spontaneous reverse translocation. Ribosomes: Form and function. North Falmouth,
MA, June 3-8, 2007. (poster)
Walker, S. E.*, McGarry, K. G. and Fredrick, K. Contribution of E-site nucleotide C2394 to
hybrid state formation and translocation. Ribosomes: Form and function. North
Falmouth, MA, June 3-8, 2007. (poster)
Walker, S. E.* and Fredrick, K. Role of the P/E state in ribosomal translocation. Rustbelt RNA
Meeting, Mt. Sterling, OH, October 19-20, 2007. (talk)
Qin, D.* and Fredrick, K. Characterization of 16S rRNA mutations that decrease the fidelity of
translation initiation. Rustbelt RNA Meeting, Mt. Sterling, OH, October 19-20, 2007.
(poster)
Shoji, S.*, Borovinskaya, M. A., Cate, J. H. D. and Fredrick, K. Effect of antibiotics on
spontaneous reverse translocation of tRNA in the ribosome. Rustbelt RNA Meeting, Mt.
Sterling, OH, October 19-20, 2007. (poster)
Walker, S. E.*, Shoji, S., Pan, D., Cooperman, B. S. and Fredrick, K. Role of hybrid tRNAbinding states in ribosomal translocation. Translational Control. Cold Spring Harbor
Laboratory, Cold Spring Harbor, NY, September 3-7, 2008. (talk)
Qin, D.* and Fredrick, K. Control of translation initiation involves a factor-induced
rearrangement of helix 44 of 16S ribosomal RNA. Rustbelt RNA Meeting, Mt. Sterling,
OH, October 17-18, 2008. (talk)
Devaraj, A.*, Shoji, S., Holbrook, E. and Fredrick, K. A role for the 30S subunit E site in
maintenance of the translational reading frame. Molecular Genetics of Bacteria &
Phages. Madison, WI, August 4-9, 2009. (talk)
Qin, D.* and Fredrick, K. Control of translation initiation involves a factor-induced
rearrangement of helix 44 of 16S ribosomal RNA. Molecular Genetics of Bacteria &
Phages. Madison, WI, August 4-9, 2009. (poster)
McClory, S.*, Leisring, J. M., Qin, D. and Fredrick, K. Missense suppressor mutations in 16S
rRNA reveal the importance of helices 8 and 14 in aminoacyl-tRNA selection.
Ribosomes 2010. Orvieto, Italy, May 3-7, 2010. (talk)
Devaraj, A.* and Fredrick, K. Short spacing between the Shine-Dalgarno and P codon
destabilizes P-site tRNA to promote +1 programmed frameshifting. Ribosomes 2010.
Orvieto, Italy, May 3-7, 2010. (poster)
Qin, D.* and Fredrick, K. A factor-induced rearrangement of helix 44 of 16S rRNA negatively
regulates 50S docking to ensure fidelity during initiation. Ribosomes 2010. Orvieto,
Italy, May 3-7, 2010. (poster)
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CURRICULUM VITAE
KURT FREDRICK
EXTRAMURAL FUNDING
Current
2010-2014
2009-2011
Previous
2005-2010
National Institutes of Health (NIGMS)
R01 GM072528
Molecular analysis of accurate ribosomal translocation
Total annual funding: $304,000
National Science Foundation (NSF)
MCB 0840996
Studies of translation initiation in bacteria
Total annual funding: $154,000
National Institutes of Health (NIGMS)
R01 GM072528
Molecular analysis of accurate ribosomal translocation
Total annual funding: $288,000
PUBLICATIONS
1. Fredrick, K. L. and Helmann, J. D. 1994. Dual chemotaxis signaling pathways in Bacillus
subtilis: A D-dependent gene encodes a novel protein with both CheW and CheY
homologous domains. J. Bacteriol. 176, 2727-2735.
2. Rosario, M. M., Fredrick, K. L., Ordal, G. W. and Helmann, J. D. 1994. Chemotaxis in Bacillus
subtilis requires either of two functionally redundant CheW homologs. J. Bacteriol. 176,
2736-2739.
3. Fredrick, K., Caramori, T., Chen, Y. F., Galizzi, A. and Helmann, J. D. 1995. Promoter
architecture in the flagellar regulon of Bacillus subtilis: High-level expression of flagellin
by the D RNA polymerase requires an upstream promoter element. Proc. Natl. Acad. Sci.
USA 92, 2582-2586.
4. Fredrick, K. and Helmann, J. D. 1996. FlgM is the primary regulator of D activity and its
absence restores motility to a sinR mutant. J. Bacteriol. 178, 7010-7013.
5. Fredrick, K. and Helmann, J. D. 1997. RNA polymerase sigma factor determines start-site
selection but is not required for upstream promoter element activation on heteroduplex
(bubble) templates. Proc. Natl. Acad. Sci. USA 94, 4982-4987.
6. Huang, X., Fredrick, K. L. and Helmann, J. D. 1998. Promoter recognition by Bacillus subtilis
W: Autoregulation and partial overlap with the X regulon. J. Bacteriol. 180, 3765-3770.
7. Fredrick, K., Dunny, G. M. and Noller, H. F. 2000. Tagging ribosomal protein S7 allows rapid
identification of mutants defective in assembly and function of 30S subunits. J. Mol. Biol.
298, 379-394.
8. Noller, H. F., Yusupov, M. M., Yusupova, G. Z., Baucom, A., Lieberman, K., Lancaster, L.,
Dallas, A., Fredrick, K., Earnest, T. N. and Cate, J. H. D. 2001. Structure of the ribosome
at 5.5 Å resolution and its interaction with functional ligands. Cold Spring Harbor Symp.
Quant. Biol. 66, 57-66.
9. Fredrick, K. and Noller, H. F. 2002. Accurate translocation of mRNA by the ribosome
requires a peptidyl group or its analog on the tRNA moving into the 30S P site. Mol. Cell
9, 1125-1131.
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CURRICULUM VITAE
KURT FREDRICK
10. Fredrick, K. and Noller, H. F. 2003. Catalysis of ribosomal translocation by sparsomycin.
Science 300, 1159-1162.
11. Hoang, L., Fredrick, K. and Noller, H. F. 2004. Creating ribosomes with an all-RNA 30S
subunit P site. Proc. Natl. Acad. Sci. USA 101, 12439-12443.
12. Noller, H. F., Hoang, L. and Fredrick, K. 2005. The 30S ribosomal P site: A function of 16S
rRNA. FEBS Lett. 579, 855-858.
13. Abdi, N. M. and Fredrick, K. 2005. Contribution of 16S rRNA nucleotides forming the 30S
subunit A and P sites to translation in E. coli. RNA 11, 1624-1632.
14. Yassin, A., Fredrick, K. and Mankin, A. S. 2005. Deleterious mutations in small subunit
ribosomal RNA identify functional sites and potential targets for antibiotics. Proc. Natl.
Acad. Sci. USA 102, 16620-16625.
15. McGarry, K. G., Walker, S. E., Wang, H. and Fredrick, K. 2005. Destabilization of the P site
codon-anticodon helix results from movement of tRNA into the P/E hybrid state. Mol.
Cell 20, 613-622.
16. Walker, S. E. and Fredrick, K. 2006. Recognition and positioning of mRNA in the ribosome
by tRNAs with expanded anticodons. J. Mol. Biol. 360, 559-609.
17. Tram, U., Fredrick, K., Werren, J. H. and Sullivan, W. 2006. Paternal chromosome
segregation during the first mitotic division determines Wolbachia-induced cytoplasmic
incompatibility. J. Cell Sci. 119, 3655-3663.
18. Shoji, S., Walker, S. E. and Fredrick, K. 2006. Reverse translocation of tRNA in the ribosome.
Mol. Cell 24, 931-942.
19. Shoji, S. and Fredrick, K. 2007. Ribosomal translocation: 3 steps forward and 1 step back?
Experimental Medicine 25, 1212-1216. (Japanese)
20. Borovinskaya, M. A., Shoji, S., Holton, J. M., Fredrick, K., and Cate, J. H. D. 2007. A steric
block in translation caused by the antibiotic spectinomycin. ACS Chem. Biol. 2, 545-552.
21. Ling, J., Roy, H., Qin, D., Rubio, M. T., Alfonzo, J. D., Fredrick, K. and Ibba, M. 2007.
Pathogenic mechanism of a human mitochondrial tRNAPhe mutation associated with
myoclonic epilepsy with ragged red fibers syndrome. Proc. Natl. Acad. Sci. USA 104,
15299-15304.
22. Qin, D., Abdi, N. M. and Fredrick, K. 2007. Characterization of 16S rRNA mutations that
decrease the fidelity of translation initiation. RNA, 13, 2348-2355.
23. Walker, S. E. and Fredrick, K. 2008. Preparation and evaluation of acylated tRNAs. Methods
44, 81-86.
24. Borovinskaya, M. A., Shoji, S., Fredrick, K., and Cate, J. H. D. 2008. Structural basis for
hygromycin B inhibition of protein biosynthesis. RNA 14, 1590-1599.
25. Walker, S. E., Shoji, S., Pan, D., Cooperman, B. S. and Fredrick, K. 2008. Role of hybrid
tRNA-binding states in ribosomal translocation. Proc. Natl. Acad. Sci. USA 105, 91929197.
26. Fredrick, K. and Ibba, M. 2009. Protein synthesis: Errors rectified in retrospect. Nature 457,
157-158.
27. Devaraj, A., Shoji, S., Holbrook, E. D., and Fredrick, K. 2009. A role for the 30S subunit E site
in maintenance of the translational reading frame. RNA 15, 255-265.
28. Qin, D. and Fredrick, K. 2009. Control of translation initiation involves a factor-induced
rearrangement of helix 44 of 16S ribosomal RNA. Mol. Microbiol. 71, 1239-1249.
29. Shoji, S., Walker, S. E., and Fredrick, K. 2009. Ribosomal translocation: One step closer to the
molecular mechanism. ACS Chem. Biol. 4, 93-107.
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CURRICULUM VITAE
KURT FREDRICK
30. Ling, J., So, B., Yadavalli, S. S., Roy, H., Shoji, S., Fredrick, K., Musier-Forsyth, K., and Ibba,
M. 2009. Resampling and editing of mischarged tRNA prior to translation elongation.
Mol. Cell 33, 654-660.
31. Shoji, S., Abdi, N. M., Bundschuh, R., and Fredrick, K. 2009. Contribution of ribosomal
residues to P-site tRNA binding. Nucleic Acids Res. 37, 4033-4042.
32. Garza-Sánchez, F., Shoji, S., Fredrick, K., and Hayes, C. S. 2009. RNase II is important for Asite mRNA cleavage during ribosome pausing. Mol. Microbiol. 73, 882-897.
33. Shoji, S., Janssen, B. D., Hayes, C. S., and Fredrick, K. 2010. Translation factor LepA
contributes to tellurite resistance in Escherichia coli but plays no apparent role in the
fidelity of protein synthesis. Biochimie 92, 157-163.
34. Fredrick, K. and Ibba, M. 2010. How the sequence of a gene can tune its translation. Cell 141,
227-229.
35. McClory, S. P., Leisring, J. M., Qin, D., and Fredrick, K. 2010. Missense suppressor
mutations in 16S rRNA reveal the importance of helices h8 and h14 in aminoacyl-tRNA
selection. RNA 16, 1925-1934.
36. McClory, S. P., Devaraj, A., Qin, D., Leisring, J. M., and Fredrick, K. 2010. Mutations in 16S
rRNA that decrease the fidelity of translation. In Ribosomes: Structure, Function, and
Dynamics, M. Rodnina et al., ed. (New York: Springer-Verlag Wien) (in press).
37. Qin, D. and Fredrick, K. 2010. Analysis of polysomes from bacteria. In Methods Navigator
Cookbook, J. Lorsch, ed. (Oxford: Elsevier) (in press).
38. Devaraj, A. and Fredrick, K. 2010. Short spacing between the Shine-Dalgarno sequence and
P codon destabilizes codon-anticodon pairing in the P site to promote +1 programmed
frameshifting. Mol. Micro (in press).
10