Before
With track changes
After
Oral canceris the leader of cancers
throuhg out world and there is a despertate
need of its early detection especially for
prolonged
abusers
of
tobacco.
tumuorigenesis has been seen to be a result
of a multi-step process involving two or
more genetic alterations ultimately leading
to transformed malignant phenotype of
cancerous cells. For a long time, cancer
has been known to be a disease caused by
arterations in the genetic blueprint of cells.
For many years, It is strongly accepted
that because of differentiation and
proliferation imbalance in molecular
signaling programs for differenciation and
proliferation can cause cancer. Another
thing that is accepted is that distinct
genetic expression programs are turned on
or off during development, growth and
differentiation.
Among cancers, oral cancer has one of
the highest incidences worldwide, and its
early detection is urgently required,
especially for long-term users of tobacco.
Tumorigenesis has been proven to be the
result of a multi-step process involving 2
or more genetic alterations that ultimately
lead to the transformed malignant
phenotype of cancerous cells. For long,
cancer has been known to be caused by
alterations in the genetic blueprint of cells.
It is widely accepted that an imbalance in
the
molecular
signaling
programs
responsible for differentiation and
proliferation can cause cancer. It is also
known that distinct gene expression
programs are switched on or off during
development, growth, and differentiation.
Among cancers, oral cancer has one of
the highest incidences worldwide, and its
early detection is urgently required,
especially for long-term users of tobacco.
Tumorigenesis has been proven to be the
result of a multi-step process involving 2
or more genetic alterations that ultimately
lead to the transformed malignant
phenotype of cancerous cells. For long,
cancer has been known to be caused by
alterations in the genetic blueprint of cells.
It is widely accepted that an imbalance in
the
molecular
signaling
programs
responsible for differentiation and
proliferation can cause cancer. It is also
known that distinct gene expression
programs are switched on or off during
development, growth, and differentiation.
, it has become apparent that
epigenetic alterations also underlie the
etiology of cancer. Epigenetic mechanisms
are those that result in the heritable
alteration of gene expression profiles
without alterations in the primary DNA
sequence. The core of epigenetic control
lies in the chemical modification of DNA
and histones. Epigenetic events such as
aberrant methylation of gene promoter
regions are associated with the loss of
gene function. This DNA change brings
about a heritable state and seems to be
tightly linked to the formation of
In the past decade, it has become
apparent that epigenetic alterations also
underlie the etiology of cancer. Epigenetic
mechanisms are those that result in the
heritable alteration of gene expression
profiles without alterations in the primary
DNA sequence. The core of epigenetic
control lies in the chemical modification
of DNA and histones. Epigenetic events
such as aberrant methylation of gene
promoter regions are associated with the
loss of gene function. This DNA change
brings about a heritable state and seems to
be tightly linked to the formation of
In the past decade it has become apparent
that epigenetic alterations also underlie the
etymology of cancer. Epigenetic
mechanisms are mechanisms that result in
heritable alteration of gene expression
profiles which is not caused by altered
primary DNA sequence. The main
epigenetic control falls in chemical
modification of DNA and histones.
Epigenetic event like aberrant methylation
of gene promoter regions is associated
with gene function lost. This changed
DNA indicates a heritable state and
seemed to tightly be linked to the form of
transcriptionally repressive chromatin.
transcriptionally repressive chromatin.
transcriptionally repressive chromatin.