2nd Bruce Ames International Symposium on Nutritional Genomics: Resolving the Diet-Gene Paradox Pre-Symposium Workshops 12 October 2007 WORKSHOP 1A (ARC BALLROOM A) Title: Fundamentals of Nutritional Genomics – a 2007 Update Coordinators: Jim Kaput, PhD and Ruth DeBusk, PhD, RD Summary: This workshop will present background information on genetics, epidemiology, and nutrition concepts important for understanding the latest results in nutritional genomics. Included will be topics associated with or supplementing the presentations at the 2nd Bruce Ames International Symposium on Nutritional Genomics including gut and brain peptides involved in appetite, new associations of genes and disease (type 2 diabetes, cardiovascular), and mechanisms of epigenetics. Target audience: Dietitians, nutritionists, nurses, physicians, postdoctoral researchers, graduate students in nutrition, biological science, or medicine/dentistry/nursing/pharmacy, and other postgraduate nutrition professionals, health care professionals, and symposium attendees interested in acquiring additional background knowledge in nutritional genomics and its applications prior to the symposium. Workshop Schedule Time 8:00 – 8:30 8:30 – 9:30 9:30 – 10:00 10:00 – 10:30 10:30 – 11:15 11:15 – 12:00 12:00 – 12:30 Hours Topic 0.5 Introduction to nutrigenomics through the 5 tenets 1.00 The basics of genetics, epistasis, epigenetics 0.30 Updates on gene associations in diabetes, CVD, and other diseases 0.50 Break 0.75 Appetite peptides in nutrigenomics 0.75 Evolving strategies in nutritional genomics research: Hormesis. homeostatic challenges, participatory research 0.50 Question-and-answer period and workshop evaluation 2nd Bruce Ames International Symposium on Nutritional Genomics: Bruce Ames Pre-Symposium Workshops, October 12, 2007 1 Resolving the Diet-Gene Paradox Pre-Symposium Workshops 12 October 2007 WORKSHOP 2A (ARC BALLROOM A) Title: Nutritional Genomics: Applications and Practice Presenters: Ruth DeBusk, PhD, RD; Colleen Fogarty Draper, MS, RD Summary: This workshop is designed to provide the basics of nutritional genomics for those interested in the practical applications of this emerging science and is particularly appropriate for those interested in the clinical applications. Target audience: Registered dietitians and other postgraduate nutrition professionals; other health care professionals, graduate and undergraduate students in nutrition, biological science, or medicine/dentistry/nursing/pharmacy; and symposium attendees interested in developing a background in nutritional genomics and its varied applications prior to the symposium Workshop Schedule: Time 1:15 – 1:45 1:45 – 3:00 3:00 – 3:25 3:25 – 3:30 3:30 – 4:45 4:45 – 5:00 5:00 – 5:15 Hours Topic 0.5 Fundamentals of nutritional genomics 1.25 Molecular nutrition: mechanisms by which environmental factors communicate with the genetic material 0.25 Nutrigenetic testing and other methodology used in nutritional genomics research and applications 0.25 Break 1.25 Applications of nutritional genomics 0.25 Ethical, legal, and social issues 0.25 Question-and-answer period and workshop evaluation Bruce Ames Pre-Symposium Workshops, October 12, 2007 2 2nd Bruce Ames International Symposium on Nutritional Genomics: Resolving the Diet-Gene Paradox Pre-Symposium Workshops 12 October 2007 WORKSHOP 2B (ARC BALLROOM B) Title: Nutritional Epigenomics: What Your Grandmother Didn’t Tell You about Nutrition and Health. Coordinators: Raymond Rodriguez, PhD and Fred Chedin, PhD Summary: This workshop will present background information on the role of epigenetics as a modulator of diet/gene interactions and its impact on long-term health outcomes. The fundamentals of DNA methylation, chromosome imprinting and chromatin modification will be discussed. Also to be covered are the health consequences of epigenetic drift and loss of imprinting. The role of diet in “reprogramming” the epigenome will be discussed. This workshop will run concurrently with Workshop 2A. Target audience: Dietitians, nutritionists, nurses, physicians, postdoctoral researchers, graduate students in nutrition, biological science, or medicine/dentistry/nursing/pharmacy, and other postgraduate nutrition professionals, health care professionals, and symposium attendees interested in acquiring additional background knowledge in nutritional genomics and its applications prior to the symposium. Workshop Schedule: Time 1:30 – 2:00 2:00 – 2:30 2:30 – 3:00 3:00 – 3:15 3:15 – 4:00 4:00 – 4:30 4:30 – 5:00 Hours 0.5 1.00 0.30 0.25 0.75 0.55 0.50 Topic Introduction to nutritional epigenomics The basics of DNA methylation The basics of the histone code and gene expression Break Loss of imprinting and epigenetic drift Role of diet in “reprogramming” the epigenome Question-and-answer period and workshop evaluation Bruce Ames Pre-Symposium Workshops, October 12, 2007 3