GASTRO-ENTEROLOGY, ENDOCRINE SYSTEM AND METABOLISM DISEASES Academic/Subject Sector Year Semester Total number of credits Integrated Course coordinator Integrated Course lecturers MED/12 Gastro-enterology MED/13 Endocrinology IV 1 7 Prof. Stefano Mariotti (mariotti@pacs.unica.it) Even student numbers: Usai P. (usaip@pacs.unica.it) Loviselli A. (alovise@pacs.unica.it) Solinas A. (asolinas@pacs.unica.it) Petrini L. (lpetrini@pacs.unica.it) Odd student numbers: Demelia L. (demelia@pacs.unica.it) Mariotti S. (mariotti@pacs.unica.it) Baroni M. (marcobaroni@pacs.unica.it) Boi F. (boi@pacs.unica.it) Aims of the course At the end of the course, students must be able to: - Evaluate critically and correlate clinical symptoms, physical signs and functional alterations with the pathogenetic causes of the main endocrine-metabolic diseases Perform the anamnesis and the clinical examination with reference to endocrine-metabolic pathologies Recognize the epidemiological and socio-economic relevance of the main endocrine-metabolic diseases Show theoretical knowledge of the classification, etiopathogenesis, clinical picture and therapeutic principles of digestive system, pancreas, liver and bile duct diseases Acquire appropriate clinical approach modalities and the basic notions to interpret the main laboratory, instrumental and imaging diagnostics tests related to such pathologies. Syllabus The course takes place during the first semester, with the following general organization Course content a) Endocrinology and Metabolism Diseases Endocrine regulation and feedback concepts. Adenohypophisis and neurohypophysis pathology. Hyperthyroidism, hypothyroidism and autoimmune thyroid pathology. Malignant and benign nodular thyroid pathology. Phosphocalcic metabolism disorder and parathyroid pathology. Disorder and enzymatic deficiencies of the adrenal gland. Adrenal cortex pathology. Adrenal medulla pathology. Autoimmune polyendocrine syndromes. Female and male gonadal pathology. Endocrine system and neoplasias. Endocrine aspects of obesity and thinness. Diabetes mellitus. Complications of diabetes. Diabetic foot. Functional hypoglycaemia. Dyslipidemia. Obesity and metabolic syndrome. Dietary aspects of endocrine diseases and diseases caused by metabolic disorders. Laboratory diagnostic algorithms in endocrine-metabolic diseases. b) Gastro-enterology: Motor diseases of the oesophagus Gastro-oesophageal reflux disease Gastritis H. Pylori infection Peptic disease Dyspepsia Digestive haemorrhages Malabsorption-Maldigestion Coeliac disease Chronic inflammatory intestinal diseases Diverticular disease Jaundice Virus-related hepatitis Cirrhosis of the liver Reference texts Basic textbooks (necessary and sufficient for the fundamental aims of the course) a) Gastro-enterology, Endocrinology and Metabolism 1. Harrison: Principi di Medicina Interna. XVI Edizione (McGraw-Hill Italia 2005) Chapters related to the course content Basic specialist textbooks (necessary and sufficient for the fundamental aims of the course, as an alternative to basic textbooks) a) Endocrinology and Metabolism: 1. G. Faglia: Malattie del Sistema Endocrino e del Metabolismo - (McGraw-Hill Italia 2006) 2. Harrison - Endocrinologia Clinica (McGraw-Hill 2007) b) Gastro-enterology: 1. Manuale UNIGASTRO ed. 2007-2009 Published by EGI Editrice Gastroenterologica Italiana (it can be purchased on-line at a discounted price on: www.pacinieditore.it) 2. Student section in the UNIGASTRO website (http://www.unigastro.it/) Further reading a) Endocrinology and Metabolism 1. Greespan’s Basic & Clinical Endocrinology 8 edition (2007) 2. Larsen et al: Williams Textbook of Endocrinology (11th ed. Saunders 2007) b) Gastro-enterology 1. Sherlock S.: Diseases of the liver and the biliary system - (Wiley-Blackwell; 11 edition, 2002) 2. Sleisenger & Fordtran's Gastrointestinal and Liver Disease, 8th edition, Saunders, 2006 3. On digestive endoscopy: Claude Liguory: Guida pratica di endoscopia digestiva - (Piccin) Teaching methods Ex-cathedra lessons, interactive teaching, professional training Assessment methods Requirements to take the exam - Exam at the end of the course (multiple choice written test) -Final oral exam to integrate with the written exam Students must already have taken the Pathology and Physiopathology exam and the Clinical Methodology exam Italian Language of instruction Where we are Interactive teaching and professional training centre: Classrooms, wards, practices and laboratories of Policlinico Universitario di Monserrato and classrooms of the Spina Didattica Further information