Principal Investigator/Program Director (Last, First, Middle):
Yeates, Todd O.
BIOGRAPHICAL SKETCH
Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
POSITION TITLE
Todd O. Yeates
Professor
eRA COMMONS USER NAME
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
University of California, Los Angeles, CA
University of California, Los Angeles, CA
DEGREE
(if applicable)
YEAR(s)
B. S.
Ph.D.
1983
1988
FIELD OF STUDY
Biochemistry
Biochemistry
A. Positions and Honors
Professional Positions
1988-1990
Postdoctoral, Research Institute of Scripps Clinic
1996-present
Adjunct Assistant to Adjunct Associate Professor, The Scripps Research Institute
1990-present
Assistant Professor, then Professor in Biochemistry, Univ. of California, Los Angeles
Awards and Honors
1984-1987 NIH/USPHS – National Research Service Award
1991-1996 NSF Presidential Young Investigator Award
1993
Sidhu Award – Pittsburgh Diffraction Society
2002
Fellow, American Association for the Advancement of Science
2004
Hanson-Dow Award for Excellence in Teaching – UCLA
2006
Plenary Lecture – German Crystallographic Society
2006
Jacob Marschak Lecture – UCLA
Panels and Service (since 2003)
Cal State LA Bioinformatics Institute – SAB and Mentor (2003-2005); DOE Genomes to Life Program,
Protein Structure Prediction - panel member (2003); NIH, Physical Biochemistry study section – ad hoc
(2003); NSF, Biological Databases and Informatics – program reviewer (2003); DOE-GTL Cellular
Interactions - panel chair (2004); Joint Center for Structural Genomics - Scientific Advisory Board (20042006); NIH Computational Biophysics Special Emphasis Panel (2004, 2005); Protein Science – Editorial
Advisory Board (2006-); NIH MSFC study section (ad hoc) (2006); NIH Computational Biophysics Special
Emphasis Panel, BCMB-Q (2006); Co-Editor, Acta Crystallographica, sect. D (2006-); NIH MSFB study
section (ad hoc) (2006); Editorial Board, Protein Engineering Design and Selection; NIH MSFD study
section (ad hoc) (6/2007, 10/2007)
B. Selected Research Publications (out of approximately 100)
King, N.P., Yeates, E.O., Yeates, T.O. (2007). Identification of Rare Slipknots in Proteins and Their
Implications for Stability and Folding. J. Mol. Biol. 373, 153-66.
Tsai, Y., Sawaya, M.R., Cannon, G.C., Cai, F., Williams, E.B., Heinhorst, S., Kerfeld, C.A., and Yeates, T.O.
(2007). Structural analysis of CsoS1A and the protein shell of the Halothiobacillus neapolitanus
carboxysome. PLoS Biol. 5, e144.
Yeates, T.O., Tsai, Y., Tanaka, S., Sawaya, M.R., Kerfeld, C.A. (2007). Self-assembly in the carboxysome: a
viral capsid-like protein shell in bacterial cells. Biochem. Soc. Trans. 35, 508-11.
Yeates, T.O. and Beeby, M. (2007). Biochemistry. Proteins in a small world.
Science 314, 1882-3.
Boutz, D.R., Cascio, D., Whitelegge, J., Perry, L.J., and Yeates, T.O. (2007). Discovery of a thermophilic
protein complex stabilized by topologically interlinked chains. J. Mol. Biol. 368, 1332-44.
PHS 398/2590 (Rev. 09/04, Reissued 4/2006)
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Biographical Sketch Format Page
Principal Investigator/Program Director (Last, First, Middle):
Yeates, Todd O.
Banatao D.R., Cascio D., Crowley C.S., Fleissner M.R., Tienson H.L., and Yeates, T.O. (2006). An approach
to crystallizing proteins by synthetic symmetrization. Proc. Natl.Acad. Sci. USA, 103, 16230-5.
Norcross, T.S. and Yeates, T.O. 2006. A framework for describing topological frustration in models of protein
folding. J. Mol. Biol. 362, 605-21.
Kerfeld, C.A., Sawaya, M.R., Tanaka, S., Nguyen, C.V., Phillips, M., Beeby, M., Yeates, T.O. 2005. Protein
structures forming the shell of primitive bacterial organelles. Science 309, 936-8.
Beeby, M., O'connor, B.D., Ryttersgaard, C., Boutz, D.R., Perry, L.J., Yeates, T.O. 2005. The Genomics of
Disulfide Bonding and Protein Stabilization in Thermophiles. PLoS Biol. 3, PLoS Biol. 3, 1549-58.
Kudryashov, D.S., Sawaya, M.R., Adisetiyo, H., Norcross, T., Hegyi, G., Reisler, E., Yeates, T.O. 2005. The
Crystal Structure of a Cross-linked Actin Dimer Suggests a Detailed Molecular Interface in F-Actin. Proc
Natl Acad Sci USA 102, 13105-14110.
Chaudhuri, B.N. and Yeates, T.O. 2005. A computational method to predict genetically encoded rare amino
acids in proteins. Genome Biol. 6, R79.
Bowers, P.M., Cokus, S.J., Eisenberg, D., and Yeates, T.O. 2004. Use of logic relationships to decipher protein
network organization. Science. 306, 2246-9.
Padilla, J.E., and Yeates, T.O. 2003. A statistic for local intensity differences: robustness to anisotropy and
pseudo-centering and utility for detecting twinning. Acta Cryst. D 59, 1124-30.
Chaudhuri, B.N., Sawaya, M.R., Kim, C.Y., Waldo, G.S., Park, M.S., Terwilliger, T.C., and Yeates, T.O. 2003.
The crystal structure of the first enzyme in the pantothenate biosynthetic pathway, ketopantoate
hydroxymethyltransferase, from M. tuberculosis. Structure 11, 753-64.
Kerfeld C.A., Sawaya, M.R., Brahmandam, V., Cascio, D., Ho, K.K., Trevithick-Sutton, C.C., Krogmann, D.W.,
and Yeates, T.O. 2003. The Crystal Structure of a Cyanobacterial Water-Soluble Carotenoid Binding
Protein. Structure 11, 55-65.
Yeates, T.O. and Padilla, J.P. 2002. Designing Supramolecular Protein Assemblies. 2002. Curr. Op. Struct.
Biol. 12, 464-470.
Mallick, P., Boutz, D.R., Eisenberg, D., and Yeates, T.O. 2002. Genomic Evidence that the Intracellular
Proteins of Archaeal Microbes Contain Disulfide Bonds. Proc. Natl. Acad. Sci. USA 99, 9679-9684.
Serag, A.A., Altenbach, C., Gingery, M., Hubbell, W.L., and Yeates, T.O. 2002. Arrangement of Subunits and
Ordering of -Strands in an Amyloid Sheet. Nature Struct. Biol. 9, 734-739.
Griffith, S.C., Sawaya, M.R., Boutz, D.R., Thapar, N., Katz, J.E., Clarke, S., and Yeates, T.O. 2002. Crystal
Structure of a Protein Repair Methyltransferase from Pyrococcus furiosus with its L-Isoaspartyle Peptide
Substrate. J.Mol.Biol., 313, 1103-1116.
Padilla, J.E., Colovos, C., and Yeates, T.O. Nanohedra: 2001. Using Symmetry to Design Self-Assembling
Protein Cages, Layers, Crystals and Filaments, Proc Natl Acad Sci USA, 98, 2217-2221.
Serag, A.A., Altenbach, C., Gingery, M., Hubbell, W.L., and Yeates, T.O. 2001. Identification of A Subunit
Interface In Transthyretin Amyloid Fibrils: Evidence for Assembly From Oligomeric Building Blocks.
Biochem. 40, 9089-96.
Toth, E.A. and Yeates, T.O. 2000. The Structure of Adenylosuccinate Lyase, an Enzyme with Dual Activity in
the de novo Purine Biosynthetic Pathway. Structure, 8, 163-174.
Eisenberg, D., Marcotte, E.M., Xenarios, I., and Yeates, T. 2000. Protein Function in the Post-Genomic Era.
Nature, 405, 823-826.
Toth, E.A., Worby, C., Dixon, J.E., Goedken, E.R., Marqusee, S., and Yeates, T.O. 2000. The Crystal Structure
of Adenylosuccinate Lyase from Pyrobaculum aerophilum Reveals an Intracellular Protein with Three
Disulfide Bonds. J. Mol. Biol., 301, 433-450.
Pellegrini, M., Marcotte, E.M., Thompson, M.J., Eisenberg, D., and Yeates, T.O. 1999. Assigning Protein
Functions by Comparative Genome Analysis: Protein Phylogenetic Profiles. PNAS, 96, 4285-4288.
Yeates, T.O. 1997. Detecting and Overcoming Crystal Twinning. Meth. Enzymol. 276, 344-358.
Wukovitz, S. W. and Yeates, T. O. 1995. Why Protein Crystals Favour Some Space Groups Over Others.
Nature Structural Biology 2, 1062-1067.
PHS 398/2590 (Rev. 09/04, Reissued 4/2006)
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Continuation Format Page