Hereditary Diffuse Gastric Cancer (HDGC) Workshop
20th and 21st November, Cambridge UK
Programme
Thursday 20th November
Winstanley Lecture Theatre, Trinity College
4 – 5 pm
Registration and Coffee/Tea - Blue Boar Common Room
5 pm
Welcome and introductions - Rebecca Fitzgerald
Chairperson: Carlos Caldas
Keynote lecture: A decade of progress in Hereditary Diffuse Gastric Cancer
David Huntsman, Vancouver, Canada
6 pm
Chairpersons: Nina Hallowell, Edinburgh and Sarah Downing, Cambridge
Patient perspectives
7 pm
Drinks
7:30 pm
Dinner in The Old Kitchen, Trinity College
Friday 21st November
Cancer Research UK Cambridge Research institute (CRI)
9 am
Tea/ Coffee
9:20 am
Outline of the day - Rebecca Fitzgerald
Session 1
9:30 am
Chairperson: Manish Shah
Carlos Caldas and Paul Pharoah - An updated linkage analysis based on the
international experience to date
10 am
Fatima Carneiro - Current status and future directions for our understanding of
pathology of HDGC and early lesions
10:30 am
Rebecca Fitzgerald - Where are we up to with endoscopic screening for individuals
at risk for HDGC?
11 am
Coffee break
Session 2
11:15 am
Chairperson: Hubert Stein
Richard Hardwick - Issues around prophylactic surgery for HDGC
11:45 am
Parry Guildford and Vanessa Blair - The New Zealand experience
12:15 am
Jeff Norton - The Stanford experience
1 – 2 pm
Lunch
Session 3
Breakout Groups (Tea will be available from 3:30pm)
2 – 4 pm
The aim of this session is to come up with a consensus statement and clear
guidelines for your topic. Key areas for future research should be outlined.
Suggested topics for discussion are listed for each topic. Each session chairs will be
responsible for helping to write revised guidelines on the management of HDGC for
publication.
Group G: Genetics
Chairpersons: Carlos Caldas and Daniel Chung
- Requirements for genetic counselling
- Age for genetic testing
- Pre-implantation genetic testing (refer to Dr Siobhan Sengupta)
- Guidelines for screening for other cancers namely breast and colon
- The question of centres of excellence
Group S: Surgery
Chairpersons: Richard Hardwick and Jeff Norton
- When should we recommend surgery?
- What issues worry our patients and how can we address these?
- What operation should we do?
- Is there a role for minimally invasive surgery
- Who should operate?
- Should we collate outcomes centrally?
Group E: Surveillance Endoscopy
Chairpersons: Rebecca Fitzgerald and Krish Raganuth
- Suggested protocols: age of subject, number of biopsies, site of biopsies, dye
spraying, trimodal imaging, frequency, pathology processing of samples
- The question of centres of excellence for these families.
Group P: Pathology
Chairpersons: Fatima Carneiro and Han van Krieken
- Classification of microscopic foci and determination of significance
- Reporting of gastrectomy specimens
- Use of immunostaining and simple stains, e.g. mucins
- The question of centres of excellence for these families
- Questions arising on molecular pathogenesis
Session 4
Report back from Breakout Groups from each chair person(s)
4 – 5 pm
Committee sum up and close
2