ASPER WELLNESS SAMPLE SUBMISSION FORM ORDERING PERSON AND REPORTING INFORMATION ADDITIONAL REPORTING INFORMATION (if applicable) Name (first name, last name) Institution Address E-mail Phone Results delivery Sample receipt confirmation by e-mail by regular mail Person E-mail BILLING INFORMATION By submitting DNA samples to Asper Biotech the client agrees that invoices shall be paid within 10 calendar days as of the invoice date and in case of delay in the payment, the open invoice amounts will accrue interest amounting to 0,1 % per calendar day. Contact person Institution Address E-mail Phone VAT account number In EU countries please add paying institution's VAT account number, otherwise 20% of VAT tax will be added to the invoice. PO number Invoice delivery by e-mail by regular mail SAMPLE INFORMATION Type whole blood in EDTA DNA Other...................................... Date of collection PATIENT INFORMATION (needed for diagnostic package) Name Date of birth Sex Ethnic origin Clinical diagnosis ASPER BIOTECH Ltd • reg Nº 10504931 • Vaksali 17A, 50410 Tartu, Estonia phone +372 7307 295 • fax +372 7307 298 • info@asperbio.com • www.asperbio.com 1 TESTS REQUIRED Genotyping service Standard delivery* Genotyping service Express delivery** Diagnostic package*** Number of samples Number of samples Number of samples Targeted mutation analysis Age-related Macular Degeneration N/A NGS panel of 21 genes N/A N/A Single mutation Alzheimer Disease, Recovery from Traumatic Brain Injury, Coronary Heart Disease Targeted mutation analysis N/A N/A Celiac Disease Targeted mutation analysis N/A N/A Lactose Intolerance Targeted mutation analysis N/A N/A Venous Thrombosis Targeted mutation analysis N/A N/A * - Genotyping service (standard delivery) Genotyping The results report by e-mail APEX-based test results will be delivered by 3-6 weeks NGS-based test results will be delivered by 8 weeks For further information about turnaround times see the detailed description of each test on http://www.asperbio.com/ Genotyping results are for research use only. Genetic counseling is recommended to follow the genetic testing. ** - Genotyping service (express delivery) Genotyping The results report by e-mail The results will be delivered by 7 working days The express delivery is 45 EUR higher than the standard delivery. *** - Diagnostic package DNA extraction Genotyping Confirmation of disease associated variants by Sanger sequencing Interpretation The results report by registered mail APEX-based test results will be delivered by 3-6 weeks NGS-based test results will be delivered by 12 weeks For diagnostic package please fill in patient’s clinical information at the end of the form. Supportive services for genotyping DNA extraction from blood, saliva or formalin-fixed paraffin-embedded tissue (35 €) Confirmation of the APEX-based analysis findings by Sanger sequencing (29 € per mutation) Confirmation of the NGS-based analysis findings by Sanger sequencing (29 or 140€ per mutation) Hard copy of the genotyping results (23 €) Sample return by courier (95 €) Shipping address....................................................................................................................................................................... Sample return by postal parcel (49 €) Shipping address....................................................................................................................................................................... ASPER BIOTECH Ltd • reg Nº 10504931 • Vaksali 17A, 50410 Tartu, Estonia phone +372 7307 295 • fax +372 7307 298 • info@asperbio.com • www.asperbio.com 2 SAMPLE INFORMATION FOR GENOTYPING SERVICE Sample code (samples should be pre-coded when sent to Asper Biotech) DNA concentration (preferred 100-250 ng/µl) Comments/Patient’s data (fill the field if patient’s data is needed for reporting and invoicing) COMMENTS PATIENT’S CLINICAL INFORMATION (needed for diagnostic package) Reason for referral confirmation of clinical diagnosis presymptomatic testing risk assessment Age at the onset of symptoms…………............................. anemia weight loss muscle atrophy gastrointestinal findings………………………………………………………………………………………………………..... ....................................................................................................................................................................................... other findings………………………………………………………………………………………………………..................... Results of the serological analyses (if applicable): Anti-tissue transglutaminase antibody IgA (tTG IgA)………………………………………………………...U/ml Anti-tissue transglutaminase antibody IgG (tTG IgG)………………………………………………………..U/ml Anti-endomysial antibody IgA (EMA IgA)……………………………………………………………………...U/ml Deamidated gliadin peptide antibody IgA (DGP IgA)………………………………………………………...U/ml Deamidated gliadin peptide antibody IgG (DGP IgG)………………………………………………………..U/ml Venous thrombosis (VT) idiopathic VT recurrent VT life-threatening VT(pulmonary embolus, cerebral vein thrombosis etc) at an unusual site (cerebral, mesenteric, portal, hepatic) while on oral contraceptives/ hormone replacement / methotrexate therapy pregnancy and postpartum period associated VT recurrent fetal loss ( 2nd and 3rd trimester) Arterial thrombosis stroke myocardial infarction Previous genetic testing not done results: ..................................................................................................................................................................................... ..................................................................................................................................................................................... ASPER BIOTECH Ltd • reg Nº 10504931 • Vaksali 17A, 50410 Tartu, Estonia phone +372 7307 295 • fax +372 7307 298 • info@asperbio.com • www.asperbio.com 3 Family history unknown diagnosis…………………………………………………………………………………………………………...................... specify the relation to the proband………………………………………………………………………………................... Important: By sending samples and placing an order customer accepts the Terms and Conditions of Asper Biotech (see website for details). ASPER BIOTECH Ltd • reg Nº 10504931 • Vaksali 17A, 50410 Tartu, Estonia phone +372 7307 295 • fax +372 7307 298 • info@asperbio.com • www.asperbio.com 4