Thomas Samuel Ram
Medical Council of India Registration No: 57826
Radiation Therapy Unit I
Christian Medical College
Vellore.632 004
Tamil Nadu.
India.
Phone: 91- 416-2283145/3185
Mobile: +91 944432 70226
Fax: 91-416-2232035
E-mail: tomsamram@cmcvellore.ac.in
Qualifications
1990—1995 MBBS Christian Medical College, Vellore, India.
1999-2002 MD (Radiation Therapy) Christian Medical College, Vellore, India.
Work History
1995-1996: Internship, Christian Medical College, Vellore, Tamil Nadu, India.
1996 - 1997: Junior Medical Officer, Padhar Mission Hospital, Madhya Pradesh, India.
1997– 1998: Junior Medical Officer, Scudder Memorial Hospital, Tamil Nadu, India.
1999-2002:Radiation Oncology Resident, Christian Medical College, Vellore, Tamil Nadu, India.
2002– 2003: Lecturer, Christian Medical College, Vellore, Tamil Nadu, India.
2003– 2004: Oncologist, Padhar Mission Hospital, Madhya Pradesh, India.
2004– 2005 : Tutor Present: Assistant Professor, Radiation Oncology, Christian Medical College,
Vellore, Tamil Nadu, India.
2005– 2009 : Assistant Professor, Radiation Oncology, Christian Medical College, Vellore, Tamil Nadu,
India.
2009– present: Associate Professor, Radiation Oncology, Christian Medical College, Vellore, Tamil
Nadu, India.
Area of Interest: Clinical and Translation Research in Gynecological and Gastrointestinal cancers.;
Educational Technology
Clinical Activities
1 Outpatient Clinics: thrice a week; 4000 – 6000 patients / year
2 Inpatient care for ~ 800 patients/year
3 Tumor Board meetings
 Weekly
o Colorectal Oncology
o Gynaecology Oncology
4
Monthly
o Uro Oncology
o Pathology-Radiology Conference
 Chemotherapy for solid tumors
Teletherapy Experience:
1 Machines
2 Theratron 780-C
4
5
3 Linear Accelerator ( 5 – 14 MeV electrons; 6MV,15MV photons)
Simulator
o Varian Ximatron
Treatment Planning System
6 Nucletron Plato 3D planning/IMRT
7 Radionics X knife
8 Brain Lab ver 5.2
9 TSG Radplan 2D planning
10 Familiar with Radiation Oncology network “LANTIS” & “ARIA”
Brachytherapy Experience:
 Low Dose Rate Brachytherapy
o Intracavitary brachytherapy for Cervical cancer
o Interstitial Implants for Cervical Cancer
o Anal Canal Implants
o Tongue Implants
o Breast Implants
o Hepatobiliary brachytherapy
1 High Dose Rate Brachytherapy – Cervical Cancer
-Soft tissue Sarcoma
-Tongue implants
-Breast implants
2 Intracoronary Brachytherapy-Assistant
Special Procedures:
3 Total Body Irradiation
4 Total Skin Electron Therapy
5 Stereotactic Radiotherapy
6 Stereotactic Radio surgery
7 3D Conformal RT
8 IMRT ( Head &Neck; Thyroid; Parotid; Lung;)
Academic Presentations & Activities
1. Teaching sessions for Radiation Oncology residents; Medical Students, Nursing students,
Radiation therapy Technology students and Nuclear Medicine Technologists.
2. Short Course on Health Data Management and Statistical Software, Department Of Biostatistics
Christian Medical College, Vellore, India.
3. Workshop on Contemporary Issues in Research Ethics & Good Clinical Practice (GCP)
Guidelines. 19th – 21st February 2007; Christian Medical College, Vellore, India.
4. Workshop on Evidence Informed Health care; Developing a protocol for a Cochrane Systematic
Review; Cochrane Systematic Review Authors on Summary of findings for Cochrane Systematic
Reviews and Grading recommendations using GRADE PRO 1st - 5th June 2009; Christian
Medical College, Vellore.
5. Workshop on “2D to 3D Brachytherapy in Gynecology”. Tata Memorial Hospital , Mumbai. 11-12th
January 2013.
Publications(Indexed)
1. N Eipe, A Dildeep, T Samuel; Endobronchial Metastasis: An Anesthetic Complication? Can J
Anaesth. 2005 May;52(5):550-1.
2. Thomas Samuel Ram, Paul B. Ravindran, Faith R. Viswanathan, Perungulam Narayan
Viswanathan, and Simon P. Pavamani Extracranial doses in Stereotactic and Conventional
radiotherapy for pituitary adenomas JOURNAL OF APPLIED CLINICAL MEDICAL
PHYSICS, VOLUME 7, NUMBER 2, SPRING 2006
3. Simon P. Pavamani ,N.R.S. Surendrababu,, Thomas Samuel Ram, Meera Thomas, P.N.
Viswanathan,Faith Rangad Viswanathan: Capillary Hemangioma involving the Middle and
External Ear: Radiotherapy as a Treatment Modality. Australasian Radiology 51 (4), 394–397
4. E. Prasad, P. N. Viswanathan, V. Faith Rangad, S. Pavamani, T. S. Ram; Maximum Tolerated
Dose - Results of Phase I Trial of Weekly Paclitaxel and Cisplatin with Radiation Therapy in
Carcinoma Cervix; International Journal of Radiation Oncology * Biology * Physics 1 September
2008 (Vol. 72, Issue 1, Page S361)
5. Thomas A, Ram T. Is close follow up feasible for high-risk cervical premalignant lesion in
developing countries? BJOG 2009;116:125
6. Thomas S Ram*, Saikat Das Simon Pavamani, Perungulam N Viswanathan, Faith R
Viswanathan 'Tuberculous peritonitis and advanced ovarian malignancy: Diagnostic dilemma in
oncology clinics in Tropical Countries Tropical Gastroenterology 2010; 31(1):59-60
7. E. Prasad, P. N. Viswanathan, V. F. Rangad, S. Pavamani, T. S. Ram; “Maximum Tolerated
Dose and Early Response d Results of a Phase I Trial of Paclitaxel and Cisplatin with Radiation
Therapy in Carcinoma of the Cervix” Clinical Oncology, Volume 21, Issue 6, August 2009, Pages
488-493
8. Pillai MR, Hariharan R, Babu JM, Lakshmi S, Chiplunkar SV, Patkar M, Tongaonkar H,
Dinshaw K, Jayshree RS, Reddy BK, Siddiqui M, Roychoudury S, Saha B, Abraham P,
Gnanamony M, Peedicayil A, Subhashini J, Ram TS, Dey B, Sharma C, Jain SK, Singh N.
“Molecular variants of HPV-16 associated with cervical cancer in Indian population” Int J
Cancer. 2009 Jul 1:125(1): 91-103
9. Gnanamony, Manu MSc; Peedicayil, Abraham MD, MPh; Subhashini, John MD, MAMS; Ram,
Thomas Samuel MD; Christopher, Solomon MSc; Gravitt, Patti PhD, MS; Abraham, Priya MD,
PhD , “Human Papillomavirus Types 16 and 18 mRNA Levels and Not DNA Levels May be
Associated With Advancing Stages of Cervical Cancer” ; International Journal of Gynecological
Cancer: November 2009 - Volume 19 - Issue 8 - pp 1415-1420
10. Saikat Das,Thomas Samuel Ram, Raju T. Chacko,Simon Pavamani, Perungulam N.
Viswanathan, ,Faith R. Viswanathan, Susy Kurian “Primitive Neuroectodermal Tumor of the
Jejunum; A Case Report and Literature Review” J Gastrointest Canc
11. Pillai Radhakrishna M; Babu Janaki M; Jissa Vinoda T; Lakshmi S; Chiplunkar Shubhada V;
Patkar M; Tongaonkar H; Reddy Krishnamurthy B; Chakka Kumar N; Siddiqui M; Roychoudury
Soma; Abraham Priya; Peedicayil Abraham; Gnanamony M; Subashini J; Ram T S; Dey Bindu;
Singh Neeta; Singh Archana; Jain S K; Jayshree R S “ Region-wise distribution of high-risk
human papillomavirus types in squamous cell carcinomas of the cervix in India”.International
journal of gynecological cancer :2010;20(6):1046-51
12. S. Varghese, T. Ram, S. Pavamani, E. Thomas, V. Jeyaseelan, P. Viswanathan Phase II Study of
Concurrent Chemo Irradiation withWeekly Cisplatin and Paclitaxel in the Treatment of Locally
Advanced Squamous Cell Carcinoma of Cervix. International Journal of Radiation Oncology *
Biology * Physics (Vol. 78, Issue 3, Supplemt 2010 Page S398)
13. Ram TS, Badkul R, Maraboyina S, Wang F. A comparative study to evaluate the efficacy of on
board imaging with cone beam CT using target registration in patients with lung tumors
undergoing stereotactic body radiation therapy and comparison with ExacTrac using skeletal
registration on Novalis Tx. J Can Res Ther 2011;7:304-7.
Publications(Non Indexed)
1. Kathreena M U, Chellarani Vjayakumar, Rajeswari Siva, Thomas Samuel; Promising Chain
Reaction in equipping women for early detection of Breast Cancer and Breast Self Examination –
An innovative approach. Kerala Nursing Forum Vol 2 , No 4, Oct – Dec 2007
Book Chapters
Lee, Mary Y., Susan Albright, Rashmi Vyas, Thomas S. Ram, and Anand Zachariah. "Using Mobile Technology to
Transform Education for Health Workers at Remote Areas." MHealth: From Smartphones to Smart Systems. By
David Metcalf. Chicago, IL: HIMSS, 2012. 124-29. Print.
Clinical Research
1.
Co-Investigator “A Double Blind Randomized Multicenter, Placebo Controlled, Parallel Group, Dose
Ranging Study to Assess the Efficacy ,Safety and Pharmacokinetics of an Oral Thrombopoetin
Receptor Agonist (SB-497115-GR), administered at 50,75 and 100 mg to Cancer Patients receiving
Multiple Cycles of Chemotherapy”
2.
Co-Investigator “A randomized, active control, double-blind, double-dummy, parallel-group multinational study to assess the efficacy, tolerability and safety of the granisetron transdermal delivery
system (GTDS) in chemotherapy-induced nausea and vomiting (CINV) associated with the
administration of moderately or highly emetogenic multi-day chemotherapy.”
3.
Co-Investigator “The Role of Proteolytic Enzymes in Preventing Radiation Induced Acute Toxicities in
Head and Neck cancer patients - A Randomized Double Blind Placebo controlled Clinical Trial”
4.
Co-Investigator “Phase I Trial of Paclitaxel as a Radiosensitiser with Cisplatin in the treatment of
Carcinoma Cervix”
5.
Co-Investigator A Multi-Center Phase III Randomized, Double-Blind Placebo-Controlled Study of the
Cancer Vaccine Stimuvax (L-BLP25 or BLP25 Liposome Vaccine) in Non-Small Cell Lung Cancer
(NSCLC) Subjects With Unresectable Stage III Disease
6.
Protocol Developed at FLIMS Switzerland “Phase II Trial of Conventional External Radiation
Therapy or IMRT with concurrent Chemotherapy followed by Brachytherapy in Cervical Cancer”
7.
Principal Investigator MD Dissertation: Rival plan analysis for pituitary tumors using conventional 3
fields and Stereotactic radiotherapy.
8.
Medical Expert; MSc Nursing Dissertation; “A study to Determine the Effectiveness of Direct
Approach, to women to women approach in education women on breast cancer an breast self
examination in selected villages of college of nursing community health programme” 2002
Co-Investigator: Phase I study of Concurrent Chemo irradiation with weekly Paclitaxel and Cisplatin
in the treatment of Carcinoma Cervix
Principal Investigator: Pilot study to determine the gene expression of 5-Fluorouracil metabolic
enzymes in patients with colorectal cancer
Principal Investigator:Phase II studyof Concurrent Chemoirradiation with weekly Paclitaxel and
Cisplatin in the treatment of Carcinoma Cervix
9.
10.
11.
Basic Research :


I had the opportunity to learn Cancer Cell line culture techniques in Dr Qi Chen’s Lab at Kansas
University Medical Centre, USA and participate in an experiment using Radiation and Ascorbate
in Ovarian Cancer cell lines.
Observer Periods :
1. Observer Neuro-Oncology at Tata Memorial Hospital, Mumbai.4th – 18th March 2005.
o
o
Objective: To learn SRT/SRS with BrainLAB mMLC
Result : Started using the Brain Lab software and mMLC for SRT/SRS/IMRT at my
institution.
2.
Observer at Long Beach Memorial Cancer Centre, California; USA with Dr Syed Nisar and Dr
Ajmel Puthawala 23rd April – 4th May 2007
o Objective : To Observe HDR Brachytherapy procedures
o Result : Observed HDR Brachytherapy, Hyperthermia, Tomotherapy, Robotic
Radiosurgery. Started using HDR brachytherapy for cervical Cancers, Soft Tissue
Sarcomas
3.
Observer at Memorial Sloan-Kettering Cancer Centre, New York;USA with Dr Michael Zelefsky,
Director Brachytherapy Services, 14th – 18th May 2007.
o Objective: To Observe HDR Procedures
o Result : Observed Prostate Seed Implants with a Robotic Isoloader; Intra Operative HDR;
Extra cranial Radio surgery
4.
Observer at Long Beach Memorial Cancer Centre, California; USA with Dr Syed Nisar and Dr
Ajmel Puthawala 4th June 2008 – 11th July 2008
o Objective : To Observe Recent radiation therapy techniques in the management of
Gynecological cancers
o Result : Observed HDR Brachytherapy ,IMRT, Hyperthermia, Tomotherapy,
5.
Observer at Gastrointestinal Services of Radiation Oncology at MD Anderson Cancer Center,
Houston , Texas, USA with Dr Sunil Krishnan; Asst Professor Gastrointestinal Radiation
Oncology; Director Translational Research 28th July 2008 – 10th August 2008
o
Objective : To Observe Recent radiation therapy techniques in the management of
Gastrointestinal cancers, Translational Research
o Result : Observed 4D treatment planning and observed some of the Molecular and Cellular
techniques in Gastrointestinal Translational research.
6. Observer at Princess Margret Hospital, Toronto, Canada: with Dr Anthony Fyles and the Gynae
Radiation Oncology team.18th October 2010 – 29th October 2010.
o Objectives: To observe Image guided External RT and Brachytherapy in Gynecological
cancers and translational research.
o Result: Observed IGRT for Gyn cancers; MRI based planning for Gyn
Brachytherapy;Prostate seed implant/volume planning/post planning;Orthotopic tumor
implants in SCID mice of cervical cancer; tour of STTAR research facility.
7. Research Internship in Radiation Gentics at Kyoto University with Prof.Takeda,
o Objectives: To study the effect and Molecular Mechanism of Concurrent Cisplatinum and
Radiation Therapy on DT40 cell lines using Reverse Genetics methods
o Result:
i. Learned skills on doing Reverse Genetics experiments on Chicken DT40 cell
lines
ii. Learned molecular lab methods like studying Cell Survival using ATP assay and
Chromosomal Break analysis.
iii. Designed and conducted a study “ Concurrent chemoradiation with Cisplatinumusing Chicken DT40 cell lines.
Fellowships/Certifications/Awards:
Fellow;7th joint FECS/ AACR/ ASCO Workshop on “Methods in Clinical Cancer Research”
Park Hotels Waldhaus, Flims, Switzerland, 18 – 24 June 2005
Advanced Ethics & Good Clinical Practice (GCP) by Indian Council of Medical Research (ICMR); Good
Clinical Practice Alliance – Europe & Christian Medical College Vellore, India.
International Gynecological Cancer Society (IGCS) Traveling Scholarship Award 2008
Kansas Modale Research Fellowship 2009 –Completed the fall semester from August – Dec 2009.
Kyoto University Global COE Research Internship Award 2012
Professional Presentations:
1. “Rival plan analysis for pituitary tumors using conventional 3 fields and Stereotactic
Radiotherapy.”– November 2002; Oral Presentation; 25th National AROI Conference, Bangalore,
India.
2. “Recent Advances in Radiation Oncology”-October 2003.Oral Presentation; Biennial National
conference of Christian Medical Association of India, Raipur, Chattisgarh, India.
3. “Update In Head & Neck Cancer” October 2005.Oral Presentation; Biennial National conference
of Christian Medical Association of India, Bangalore, India
4. “Recent Advances in Cervical Cancer” June 2006, Oral Presentation at the Doctors Conference of
Christian Medical Association of India, Kodaikanal, Tamil Nadu, India.
5. “ Radiation Therapy –Medical Aspects” October 2007 Oral presentation; One – Day Seminar on
Applications of Ionizing Radiation in Medicine of Indian Nuclear Society, Mysore, Tamil Nadu,
India.
6. “Radiotherapy in Thyroid Orbitopathy” Oral Presentation, January 2008, Continuing Medical
Education, by Department of Ophthalmology, Christian Medical College, Vellore, Tamilnadu,
India.
7. “Clinical aspects of Cranial Stereotactic Radiosurgery and Stereotactic Radiation therapy”
Invited speaker, Tamil Nadu State AROI meeting, Coimbatore, October 2008,Tamil Nadu, India.
8. “A comparative study to evaluate the efficacy of On Board Imaging with Cone Beam CT
using target registration in patients with Lung tumors undergoing Stereotactic Body
Radiation Therapy (SBRT) and comparison with Exactrac using skeletal registration on
Novalis Tx” Poster and Oral Presentation at the National AROI
Conference,Patna,Bihar,India. November 2010
9. “New Developments in Radiotherapy” International Conference on Evidence & Excellence in
Obstetrics and Gynecology, Thrissur, Kerala,India. 13th November 2011
10. “Radiogenomics of Concurrent Chemoradiation with Cisplatinum using Chicken Dt40 cells
Lines” Kyoto University, Kyoto,Japan.15th November 2012.
11. “Selecting patients for neoadjuvant treatment” Continuing Medical Education in Colorectal
Surgery,Christian Medical College,Vellore,November 26th to 28th 2012.
Professional Associations:
1
2
3
4
5
6
7
Association Of Radiation Oncologists of India (AROI)
Indian Brachytherapy Society (IBS)
Christian Medical Association of India ( CMAI)
Associate Member-American Association Of Cancer Research (AACR)
International Gynecologic Cancer Society (IGCS)
European Society for Therapeutic Radiology and Oncology(ESTRO)
American Society of Therapeutic Radiology and Oncology ( ASTRO)
Languages
English, Hindi, Tamil, Marathi.
Volunteer Experience
1 Visiting Oncologist; Christian Cancer Centre, Kakinada, Andhra Pradesh, India.
2 Visiting Oncologist; Padhar Hospital, Madhya Pradesh, India.
3 Cancer detection camps in rural areas of Tamil Nadu and Madhya Pradesh.