BACITRACIN
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
COMPOUND DESCRIPTOR
:
:
:
:
:
:
CP0175000
Bacitracin
1405-87-4
199701
14
Drug
Mutagen
SYNONYMS/TRADE NAMES :
* Ayfivin
* Baciguent
* Baci-Jel
* Baciliquin
* Bacitek ointment
* Fortracin
* Parentracin
* Penitracin
* Topitracin
* Topitrasin
* USAF CB-7
* Zutracin
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 190 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.11903/04Volume(issue)/page/year: 64,503,1947
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >3750 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AAGAAW Antimicrobial Agents Annual. (New York, NY) 1960. For publisher
information, see AMACCQ. Volume(issue)/page/year: -,595,1960
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1300 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.11903/04Volume(issue)/page/year: 64,503,1947
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 360 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.11903/04Volume(issue)/page/year: 64,503,1947
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC)
V.1-12, 1951-62. For publisher information, see CLMEA3.
Volume(issue)/page/year: 4,304,1954
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - quail
DOSE/DURATION
: >316 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1
E.
First St., Duluth, MN 55802) V.11977- Volume(issue)/page/year:
6,149,1982
** MUTATION DATA **
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 50 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
89,95,1981
*** REVIEWS ***
TOXICOLOGY REVIEW
MMWOAU Muenchener Medicinische Wochenschrift. (Munich, Fed. Rep. Ger.)
V.33-115, 1886-1973. Volume(issue)/page/year: 115,1661,1973
TOXICOLOGY REVIEW
AJMEAZ American Journal of Medicine.
(Technical Pub., 875 Third Ave.,
New
York, NY 10022) V.1-
1946-
Volume(issue)/page/year: 38,409,1965
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84423
No. of Facilities: 898 (estimated)
No. of Industries: 12
No. of Occupations: 16
No. of Employees: 25810 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X9493
No. of Facilities: 266 (estimated)
No. of Industries: 5
No. of Occupations: 11
No. of Employees: 15530 (estimated)
No. of Female Employees: 14785 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84423
No. of Facilities: 1773 (estimated)
No. of Industries: 12
No. of Occupations: 23
No. of Employees: 117226 (estimated)
No. of Female Employees: 98652 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BACLOFEN
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
MW5084200
Hydrocinnamic acid, beta-(aminomethyl)-p-chloro1134-47-0
2104494
199904
17
C10-H12-Cl-N-O2
213.68
Z1YR DG&1VQ
Drug
Human
SYNONYMS/TRADE NAMES :
* gamma-Amino-beta-(p-chlorophenyl)butyric acid
* beta-(Aminomethyl)-p-chlorohydrocinnamic acid
* beta-(Aminomethyl)-4-chlorobenzenepropanoic acid
* Ba 34647
* Baclofen
* Baclon
* Benzenepropanoic acid, beta-(aminomethyl)-4-chloro* C 34647Ba
* beta-(p-Chlorophenyl)-gamma-aminobutyric acid
* beta-(4-Chlorophenyl)gaba
* Ciba 34,647-Ba
* Lioresal
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 9 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - coma
Lungs, Thorax, or Respiration - other changes
REFERENCE :
PGMJAO Postgraduate Medical Journal. (Blackwell Scientific Pub. Ltd.,
POB
88, Oxford, UK) V.11925- Volume(issue)/page/year: 56,865,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 8 mg/kg
TOXIC EFFECTS :
Cardiac - pulse rate
Lungs, Thorax, or Respiration - respiratory depression
Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
PGMJAO Postgraduate Medical Journal. (Blackwell Scientific Pub. Ltd.,
POB
88, Oxford, UK) V.11925- Volume(issue)/page/year: 57,580,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 571 ug/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
APHRER Annals of Pharmacotherpy. (Harvey Whitney Books Co., POB 42696,
Cincinnati, OH 45242) V. 261992- Volume(issue)/page/year:
27,883,1993
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Human - man
3429 mg/kg
TOXIC EFFECTS :
Behavioral - coma
Cardiac - pulse rate increase, without fall in BP
Lungs, Thorax, or Respiration - respiratory obstruction
REFERENCE :
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270
Madison Ave., New York, NY 10016) V.191982Volume(issue)/page/year:
32,291,1994
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 18 mg/kg
TOXIC EFFECTS :
Behavioral - coma
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270
Madison Ave., New York, NY 10016) V.191982Volume(issue)/page/year:
22,11,1984
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 14 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
Behavioral - coma
REFERENCE :
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270
Madison Ave., New York, NY 10016) V.191982Volume(issue)/page/year:
20,59,1983
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 4286 ug/kg
TOXIC EFFECTS :
Behavioral - coma
Cardiac - pulse rate
Vascular - BP lowering not characterized in autonomic section
REFERENCE :
AJEMEN American Journal of Emergency Medicine. (WB Saunders,
Philadelphia,
PA) V.11983- Volume(issue)/page/year: 4,552,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 25 ug/kg/2D-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
Behavioral - coma
REFERENCE :
IJCPB5 International Journal of Clinical Pharmacology, Therapy and
Toxicology. (Dustri-Verlag Dr. Karl Feistle, Postfach 49, D-8024
Munich-Deisenhofen, Fed. Rep. Ger.) V.6-10, 1972-74; V.18Volume(issue)/page/year: 29,274,1991
1980-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 145 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,576,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 115 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.11970Volume(issue)/page/year: 11,181,1980
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 78 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.11970Volume(issue)/page/year: 11,181,1980
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,576,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 103 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.11970Volume(issue)/page/year: 11,181,1980
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 31 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - ataxia
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka
Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.11959Volume(issue)/page/year: 21,2069,1979
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1500 mg/kg/30D-I
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku,
Tokyo,
Japan) V.11950- Volume(issue)/page/year: 31,871,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1820 mg/kg/26W-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
Behavioral - muscle weakness
Behavioral - ataxia
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku,
Tokyo,
Japan) V.11950- Volume(issue)/page/year: 31,871,1980
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X5585
No. of Facilities: 35 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 497 (estimated)
No. of Female Employees: 251 (estimated)
BALSAM CANADA
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
: CP2352500
: Balsams, canada
: 8007-47-4
LAST UPDATED
: 199701
DATA ITEMS CITED
: 5
SYNONYMS/TRADE NAMES :
* Balsam of fir
* Canadian balsam
* Fir balsam absolute
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 13,449,1975
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 13,449,1975
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X1612
No. of Facilities: 24 (estimated)
No. of Industries: 1
No. of Occupations: 4
No. of Employees: 210 (estimated)
No. of Female Employees: 104 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BARBITAL
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
CQ3500000
Barbituric acid, 5,5-diethyl57-44-3
0163999
5-24-09-00137 (Beilstein Handbook Reference)
199612
24
C8-H12-N2-O3
184.22
T6VMVMV FHJ F2 F2
Drug
Mutagen
SYNONYMS/TRADE NAMES :
* Barbital
* Barbitone
* DEBA
* Diemal
* Diethylbarbitone
* Diethyl-barbituric acid
* 5,5-Diethylbarbituric acid
* Diethylmalonylurea
* Dormonal
* Ethylbarbital
* Hypnogene
* Kyselina 5,5-diethylbarbiturova
* Malonal
* 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5,5-diethyl* Sedeval
* Uronal
* Veroletten
* Verolettin
* Veronal
* Vesperal
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 246 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18,
Berlin DDR-1020, Ger. Dem. Rep.) V.11946- Volume(issue)/page/year:
8,913,1953
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 450 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 152,341,1930
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,590,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 178 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia,
Italy) V.8-43 1953-88 For publisher information, see FRMCE8
Volume(issue)/page/year: 14,269,1959
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 630 mg/kg
TOXIC EFFECTS :
Behavioral - sleep
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - other changes
REFERENCE :
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai,
2-12-15
Shibuya, Shibuya-ku, Tokyo 150, Japan) No.11881Volume(issue)/page/year: 74,122,1954
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 250 mg/kg
TOXIC EFFECTS :
Behavioral - ataxia
Behavioral - rigidity (including catalepsy)
Behavioral - analgesia
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 33,43,1928
V.1-
1909/10-
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 275 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 44,325,1932
1909/10-
&
V.1-
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 225 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 44,325,1932
V.1-
1909/10-
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JACSAT Journal of the American Chemical Society. (American Chemical
Soc.,
Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
20037) V.11879- Volume(issue)/page/year: 45,243,1923
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 350 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPPGAR Journal de Physiologie et de Pathologie Generale. (Paris, France)
V.1-38, 1899-1945. For publisher information, see JOPHAN.
Volume(issue)/page/year: 30,364,1932
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Bird - chicken
DOSE/DURATION
: 225 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHREA7 Physiological Reviews. (American Physiological Soc., 9650
Rockville
Pike, Bethesda, MD 20814) V.11921- Volume(issue)/page/year:
19,472,1939
** MUTATION DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
TEST SYSTEM
DOSE/DURATION
REFERENCE :
:
:
:
:
Morphological transformation
Oral
Rodent - rat
12600 mg/kg/6W
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 9,387,1988
TYPE OF TEST
: Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 100 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
343,157,1995
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 33 gm/kg
REFERENCE :
IJMRAQ Indian Journal of Medical Research. (Indian Council of Medical
Research, Ansari Nagar, New Delhi 110 029, India) V.11913Volume(issue)/page/year: 61,1568,1973
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 33 gm/kg
REFERENCE :
IJMRAQ Indian Journal of Medical Research. (Indian Council of Medical
Research, Ansari Nagar, New Delhi 110 029, India) V.11913Volume(issue)/page/year: 61,1568,1973
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 1 gm/L
REFERENCE :
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York,
Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.11978Volume(issue)/page/year: 4,41,1980
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Fibroblast
DOSE/DURATION
: 2 gm/L/48H
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
48,337,1977
*** REVIEWS ***
TOXICOLOGY REVIEW
NEURAI Neurology.
(Modern Medicine Pub., Inc., 1 E. First St., Duluth,
MN
55802)
V.1-
1951-
Volume(issue)/page/year: 3,58,1953
TOXICOLOGY REVIEW
PHREA7 Physiological Reviews. (American Physiological Soc., 9650
Rockville
Pike, Bethesda, MD 20814) V.11921- Volume(issue)/page/year:
19,472,1939
TOXICOLOGY REVIEW
FNSCA6 Forensic Science.
(Lausanne, Switzerland)
V.1-11, 1972-78. For
pub
lisher information, see FSINDR.
Volume(issue)/page/year: 2,67,1973
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84316
No. of Facilities: 605 (estimated)
No. of Industries: 3
No. of Occupations: 4
No. of Employees: 4834 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84316
No. of Facilities: 538 (estimated)
No. of Industries: 1
No. of Occupations: 5
No. of Employees: 11338 (estimated)
No. of Female Employees: 8933 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: In vivo cytogenetics-nonhuman bone
marrow
EPA GENETOX PROGRAM 1988, Negative: In vitro SCE-nonhuman
BARBITAL SODIUM SALT
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
CQ3850000
Barbituric acid, 5,5-diethyl-, sodium salt
144-02-5
199706
32
C8-H12-N2-O3.Na
207.21
T6VMVMV FHJ F2 F2 &-NATumorigen
Drug
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Barbital Na
* Barbital sodium
* Barbital, sodium deriv.
* Barbital soluble
* Barbitone sodium
* Barbitone, sodium deriv.
* Diethylbarbiturate monosodium
* 5,5-Diethylbarbituric acid sodium deriv.
* Diethylmalonylurea sodium
* Embinal
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
Medinal
Natrinal
Natriumbarbitals
Nervoseton
2,4,6(1H,3H,5H)-Pyrimidinetrione, 5,5-diethyl-, monosodium salt
Sodium barbital
Sodium barbitone
Sodium diethylbarbiturate
Sodium 5,5-diethylbarbiturate
Sodium ethylbarbital
Sodium malonylurea
Sodium veronal
Soluble barbital
Soprinal
Thyalone
Veronal sodium
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
54,275,1983
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept.,
2350
Virginia Ave., Hagerstown, MD 21740) V.11940Volume(issue)/page/year:
17,43,1956
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 31,1,1927
TYPE OF TEST
V.1-
: LD50 - Lethal dose, 50 percent kill
1909/10-
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 280 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 135,213,1962
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
27,70,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 620 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 87,265,1946
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 109,268,1953
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 830 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
27,70,1974
TYPE OF TEST
ROUTE OF EXPOSURE
: LDLo - Lowest published lethal dose
: Intravenous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 300 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 60,125,1937
V.1-
1909/10-
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed.,
Barnes,
C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973
Volume(issue)/page/year: -,52,1973
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 400 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
Behavioral - general anesthetic
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 39,177,1930
V.1-
1909/10-
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 275 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 42,253,1931
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 42,253,1931
V.1-
1909/10-
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 290 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 31,1,1927
V.1-
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 400 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
1909/10-
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 60,125,1937
V.1-
1909/10-
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Behavioral - sleep
REFERENCE :
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.11849Volume(issue)/page/year: 128,678,1938
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 33600 mg/kg/40W-C
TOXIC EFFECTS :
Liver - other changes
Liver - changes in liver weight
Kidney, Ureter, Bladder - other changes
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
96,494,1988
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 554 gm/kg/2.7Y-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Related to Chronic Data - death
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 42,217,1931
V.1-
1909/10-
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 121 gm/kg/72W-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 11,2149,1990
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 30 mg/kg/78W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 10,183,1989
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 200 mg/kg
SEX/DURATION
: female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
SJDBA9 Soviet Journal Developmental Biology (English Translation).
Translation of Ontogenez. (Plenum Pub. Corp., 233 Spring St., New York,
NY
10013) V.11970- Volume(issue)/page/year: 10,574,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 2400 mg/kg
SEX/DURATION
: female 8-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Fertility - litter size (e.g. # fetuses per litter;
measured
before birth)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
CUSCAM Current Science. (Current Science Assoc., Sadashivanagar P.O.,
Bangalore 560 080, India) V.11932- Volume(issue)/page/year:
36,3,1967
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 2600 mg/kg
SEX/DURATION
: female 7-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications &
Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1Volume(issue)/page/year: 15,346,1977
1963-
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 6 gm/kg
SEX/DURATION
: male 20 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's
gland,
accessory glands
REFERENCE :
CUSCAM Current Science. (Current Science Assoc., Sadashivanagar P.O.,
Bangalore 560 080, India) V.11932- Volume(issue)/page/year:
34,584,1965
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE
: 125 mg/kg
SEX/DURATION
: female 19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
JCPPAV Journal of Comparative and Physiological Psychology. (Washington,
DC) V.40-96, 1947-82. Volume(issue)/page/year: 45,146,1952
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 390 mg/kg
SEX/DURATION
: female 1-6 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
Reproductive - Specific Developmental Abnormalities - body wall
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 19,1309,1969
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 390 mg/kg
SEX/DURATION
: female 1-6 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 19,1309,1969
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 690 mg/kg
SEX/DURATION
: female 1-6 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 19,1309,1969
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 120 mg/kg
SEX/DURATION
: female 3 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book
Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.11960Volume(issue)/page/year: 22,183,1970
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 240 mg/kg
SEX/DURATION
: female 3 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32,
Commerce Way, Colchester, Essex CO2 8HP, UK) V.11939Volume(issue)/page/year: 37,327,1967
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M0315
No. of Facilities: 1799 (estimated)
No. of Industries: 5
No. of Occupations: 10
No. of Employees: 12999 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M0315
No. of Facilities: 757 (estimated)
No. of Industries: 3
No. of Occupations: 12
No. of Employees: 16027 (estimated)
No. of Female Employees: 12575 (estimated)
BARBITURIC ACID
RTECS NUMBER
: CP8000000
CHEMICAL NAME
: Barbituric acid
CAS REGISTRY NUMBER
: 67-52-7
OTHER CAS REGISTRY NOS. : 32267-40-6
LAST UPDATED
: 199710
DATA ITEMS CITED
: 6
MOLECULAR FORMULA
: C4-H4-N2-O3
MOLECULAR WEIGHT
: 128.10
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
* Hydrouracil, 6-hydroxy* 6-Hydroxyuracil
* Malonylurea
* Pyrimidinetriol
* 2,4,6-Pyrimidinetriol
* 2,4,6-Pyrimidinetrione
* 2,4,6(1H,3H,5H)-Pyrimidinetrione
* 2,4,6-Trihydroxypyrimidine
* 2,4,6-Trioxohexahydropyrimidine
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
18,185,1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 505 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai,
2-12-15
Shibuya, Shibuya-ku, Tokyo 150, Japan) No.11881-
Volume(issue)/page/year: 106,504,1986
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 81718
No. of Facilities: 28 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 700 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 81718
No. of Facilities: 79 (estimated)
No. of Industries: 4
No. of Occupations: 5
No. of Employees: 3529 (estimated)
No. of Female Employees: 1481 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
BARIUM
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
SYNONYMS/TRADE NAMES :
* Barium
:
:
:
:
:
:
:
:
CQ8370000
Barium
7440-39-3
199907
33
Ba
137.34
.BA
*** HEALTH HAZARD DATA ***
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 26622 mg/kg/69W-C
TOXIC EFFECTS :
Vascular - BP elevation not characterized in autonomic section
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - cytochrome oxidases (including oxidative phosphorylation)
Biochemical - Metabolism (Intermediary) - xanthine, purine or nucleotides
including urate
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76-
Volume(issue)/page/year: 28,373,1989
*** REVIEWS ***
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 0.5 mg/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.5 mg/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,21,1971
OSHA PEL (Gen Indu):8H TWA 0.5 mg(Ba)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 0.5 mg(Ba)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 0.5 mg(Ba)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 0.5 mg(Ba)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 0.5 mg/m3 JAN 1993
OEL-AUSTRIA:TWA 0.5 mg/m3 JAN 1993
OEL-BELGIUM:TWA 0.5 mg/m3 JAN 1993
OEL-DENMARK: TWA 0.5 mg/m3, JAN1999
OEL-FINLAND:TWA 0.5 mg/m3 JAN 1993
OEL-GERMANY:TWA 0.5 mg/m3 (total dust) JAN 1993
OEL-HUNGARY:STEL 0.5 mg/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 0.5 mg/m3 JAN 1993
OEL-THE PHILIPPINES:TWA 0.5 mg/m3 JAN 1993
OEL-POLAND: MAC(TWA) 0.5 mg/m3, MAC(STEL) 1.5 mg/m3, JAN1999
OEL-SWEDEN: TWA 0.5 mg/m3, JAN1999
OEL-SWITZERLAND:TWA 0.5 mg/m3;STEL 1 mg/m3 JAN 1993
OEL-TURKEY:TWA 0.5 mg/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.5 mg/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO BARIUM, soluble compounds-air:10H TWA 0.5 mg/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 08625
No. of Facilities: 657 (estimated)
No. of Industries: 13
No. of Occupations: 31
No. of Employees: 6101 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 08625
No. of Facilities: 901 (estimated)
No. of Industries: 15
No. of Occupations: 64
No. of Employees: 10394 (estimated)
No. of Female Employees: 3598 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Barium, soluble compounds, 7056
NIOSH Analytical Method, 1994: Metals in urine, 8310
BARIUM ACETATE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
SYNONYMS/TRADE NAMES :
* Barium acetate
* Barium diacetate
* Octan barnaty
:
:
:
:
:
:
:
:
AF4550000
Acetic acid, barium salt
543-80-6
199907
32
C4-H6-O4.Ba
255.44
QV1 &-BA-
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 921 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MarJV# Personal Communication from J.V. Marhold, VUOS, 539-18, Pardubice,
Czechoslavakia, Mar. 29, 1977 Volume(issue)/page/year: 29MAR1977
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 21 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
22,150,1972
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 236 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed.
Rep.
Ger.) V.1-5, 1975-76. Discontinued. Volume(issue)/page/year: 1,1,1975
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 96 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed.
Rep.
Ger.) V.1-5, 1975-76. Discontinued. Volume(issue)/page/year: 1,1,1975
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 12 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed.
Rep.
Ger.) V.1-5, 1975-76. Discontinued. Volume(issue)/page/year: 1,1,1975
*** REVIEWS ***
ACGIH TLV-TWA 0.5 mg(Ba)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.5 mg(Ba)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,21,1971
OSHA PEL (Gen Indu):8H TWA 0.5 mg(Ba)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 0.5 mg(Ba)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 0.5 mg(Ba)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 0.5 mg(Ba)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-AUSTRIA: MAK 0.5 mg(Ba)/m3, JAN1999
OEL-AUSTRIA:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-BELGIUM:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-DENMARK: TWA 0.5 mg(Ba)/m3, JAN1999
OEL-FINLAND:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-FRANCE: VME 0.5 mg(Ba)/m3, JAN1999
OEL-GERMANY:TWA 0.5 mg(Ba)/m3 (total dust) JAN 1993
OEL-HUNGARY:STEL 0.5 mg(Ba)/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-THE PHILIPPINES:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-POLAND: MAC(TWA) 0.5 mg(Ba)/m3, MAC(STEL) 1.5 mg(Ba)/m3, JAN1999
OEL-SWITZERLAND:TWA 0.5 mg(Ba)/m3;STEL 1 mg(Ba)/m3 JAN 1993
OEL-TURKEY:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84519
No. of Facilities: 203 (estimated)
No. of Industries: 5
No. of Occupations: 7
No. of Employees: 949 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84519
No. of Facilities: 56 (estimated)
No. of Industries: 4
No. of Occupations: 11
No. of Employees: 2719 (estimated)
No. of Female Employees: 759 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BARIUM CARBONATE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
CQ8600000
Barium carbonate (1:1)
513-77-9
199907
43
C-O3.Ba
197.35
QVQ &-BAAgricultural Chemical
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Barium carbonate
* Barium monocarbonate
* BF 1 (salt)
* Carbonic acid, barium salt (1:1)
* C.I. 77099
* C.I. Pigment White 10
* Pigment White 10
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 800 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Cardiac - change in rate
Cardiac - other changes
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku,
Tokyo,
Japan) V.11950- Volume(issue)/page/year: 28,329,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 800 mg/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea
Gastrointestinal - nausea or vomiting
Lungs, Thorax, or Respiration - other changes
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK)
Volume(issue)/page/year:
289,882,1984
V.1-
1857-
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human
DOSE/DURATION
: 11 mg/kg
TOXIC EFFECTS :
Gastrointestinal - ulceration or bleeding from stomach
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku,
Tokyo,
Japan) V.11950- Volume(issue)/page/year: 31,1247,1980
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human
DOSE/DURATION
: 17 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku,
Tokyo,
Japan) V.11950- Volume(issue)/page/year: 28,329,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human
DOSE/DURATION
: 29 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Peripheral Nerve and Sensation - paresthesis
Behavioral - muscle weakness
REFERENCE :
IJMDAI Israel Journal of Medical Sciences. (POB 1435, Jerusalem 91013,
Israel) V.11965- Volume(issue)/page/year: 3,565,1967
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 418 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,23,1982
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 20 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EQSSDX Environmental Quality and Safety, Supplement.
(Stuttgart, Fed.
Rep.
Ger.)
V.1-5, 1975-76. Discontinued.
Volume(issue)/page/year: 1,1,1975
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,23,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,23,1982
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCOC** Pesticide Chemicals Official Compendium, Association of the
American
Pesticide Control Officials, Inc., 1966. (Topeka, KS)
Volume(issue)/page/year: -,95,1966
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 4 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku,
Tokyo,
Japan) V.11950- Volume(issue)/page/year: 28,329,1977
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TCLo - Lowest published toxic concentration
Inhalation
Rodent - rat
5200 ug/m3/17W-I
TOXIC EFFECTS :
Vascular - BP elevation not characterized in autonomic section
Nutritional and Gross Metabolic - changes in phosphorus
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 39(1),27,1974
(V/O
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intratracheal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 750 mg/kg/13W-I
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 26(9),10,1982
** REPRODUCTIVE DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1150 ug/m3/24H
SEX/DURATION
: male 16 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 20(7),33,1976
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 3130 ug/m3/24H
SEX/DURATION
: female 16 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - oogenesis
Reproductive - Maternal Effects - ovaries, fallopian tubes
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 20(7),33,1976
*** REVIEWS ***
ACGIH TLV-TWA 0.5 mg(Ba)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.5 mg(Ba)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,21,1971
OSHA PEL (Gen Indu):8H TWA 0.5 mg(Ba)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 0.5 mg(Ba)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 0.5 mg(Ba)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 0.5 mg(Ba)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-AUSTRIA: MAK 0.5 mg(Ba)/m3, JAN1999
OEL-AUSTRIA:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-BELGIUM:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-DENMARK: TWA 0.5 mg(Ba)/m3, JAN1999
OEL-FINLAND:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-GERMANY:TWA 0.5 mg(Ba)/m3 (total dust) JAN 1993
OEL-HUNGARY:STEL 0.5 mg(Ba)/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-THE PHILIPPINES:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-POLAND: MAC(TWA) 0.5 mg(Ba)/m3, MAC(STEL) 1.5 mg(Ba)/m3, JAN1999
OEL-SWEDEN: TWA0.5 mg(Ba)/m3, JAN1999
OEL-RUSSIA:STEL 0.5 mg/m3 JAN 1993
OEL-SWITZERLAND:TWA 0.5 mg(Ba)/m3;STEL 1 mg(Ba)/m3 JAN 1993
OEL-TURKEY:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 08640
No. of Facilities: 993 (estimated)
No. of Industries: 28
No. of Occupations: 38
No. of Employees: 14843 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 08640
No. of Facilities: 5689 (estimated)
No. of Industries: 97
No. of Occupations: 61
No. of Employees: 88778 (estimated)
No. of Female Employees: 13598 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BARIUM CHLORIDE
RTECS NUMBER
: CQ8751000
CHEMICAL NAME
: Barium chloride, dihydrate
CAS REGISTRY NUMBER
: 10326-27-9
LAST UPDATED
: 199907
DATA ITEMS CITED
: 33
MOLECULAR FORMULA
: Ba-Cl2.2H2-O
MOLECULAR WEIGHT
: 244.28
COMPOUND DESCRIPTOR
: Tumorigen
SYNONYMS/TRADE NAMES :
* Barium dichloride dihydrate
* NCI-C61074
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 51 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
63,461,1982
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 16 gm/kg/13W-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in bladder weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Nutritional and Gross Metabolic - changes in phosphorus
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 19,527,1992
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 47 gm/kg/13W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 19,527,1992
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1868 mg/kg/15D-C
TOXIC EFFECTS :
Liver - changes in liver weight
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-432,1994
(Research
*** REVIEWS ***
ACGIH TLV-TWA 0.5 mg(Ba)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.5 mg(Ba)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,21,1971
OSHA PEL (Gen Indu):8H TWA 0.5 mg(Ba)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 0.5 mg(Ba)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 0.5 mg(Ba)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 0.5 mg(Ba)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-AUSTRIA: MAK 0.5 mg(Ba)/m3, JAN1999
OEL-AUSTRIA:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-BELGIUM:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-DENMARK: TWA 0.5 mg(Ba)/m3, JAN1999
OEL-FINLAND:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-FRANCE: VME 0.5 mg(Ba)/m3, JAN1999
OEL-GERMANY:TWA 0.5 mg(Ba)/m3 (total dust) JAN 1993
OEL-HUNGARY:STEL 0.5 mg(Ba)/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-THE PHILIPPINES:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-POLAND: MAC(TWA) 0.5 mg(Ba)/m3, MAC(STEL) 1.5 mg(Ba)/m3, JAN1999
OEL-SWEDEN: TWA 0.5 mg(Ba)/m3, JAN1999
OEL-SWITZERLAND:TWA 0.5 mg(Ba)/m3;STEL 1 mg(Ba)/m3 JAN 1993
OEL-TURKEY:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X7401
No. of Facilities: 42 (estimated)
No. of Industries: 3
No. of Occupations: 3
No. of Employees: 320 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NTP Carcinogenesis studies (drinking);no evidence:mouse,rat
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-432,1994
BARIUM CHLORIDE ANHYDROUS
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
WISWESSER LINE NOTATION :
COMPOUND DESCRIPTOR
:
SYNONYMS/TRADE NAMES :
* Barium dichloride
* NCI-C61074
* SBA 0108E
CQ8750000
Barium chloride
10361-37-2
199907
54
Ba-Cl2
208.24
BA G2
Mutagen
Reproductive Effector
(Research
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 118 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher
information, see JFDSAZ. Volume(issue)/page/year: 7,313,1942
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 178 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed.,
Barnes,
C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973
Volume(issue)/page/year: -,53,1973
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 20 mg/kg
TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity
Lungs, Thorax, or Respiration - other changes
REFERENCE :
JLCMAK Journal of Laboratory and Clinical Medicine. (C.V. Mosby Co.,
11830
Westline Industrial Dr., St. Louis, MO 63141) V.11915Volume(issue)/page/year: 15,35,1929
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 70 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed.
Rep.
Ger.) V.1-5, 1975-76. Discontinued. Volume(issue)/page/year: 1,1,1975
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 39 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FATOBP Farmakologiya i Toksikologiya (Kiev). Pharmacology and
Toxicology.
(Kievskii Nauchno- Issledovatel'skii Institut Farmakologii i
Toksikologii,
Kiev, USSR) No.11964- Volume(issue)/page/year: 10,107,1975
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AEC-TR-6710
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 12 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
22,150,1972
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 90 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed.,
Barnes,
C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973
Volume(issue)/page/year: -,53,1973
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed.
Rep.
Ger.) V.1-5, 1975-76. Discontinued. Volume(issue)/page/year: 1,1,1975
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 18 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed.
Rep.
Ger.) V.1-5, 1975-76. Discontinued. Volume(issue)/page/year: 1,1,1975
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 40 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed.
Rep.
Ger.) V.1-5, 1975-76. Discontinued. Volume(issue)/page/year: 1,1,1975
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 170 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed.,
Barnes,
C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973
Volume(issue)/page/year: -,53,1973
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 40 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed.
Rep.
Ger.) V.1-5, 1975-76. Discontinued. Volume(issue)/page/year: 1,1,1975
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 15 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed.
Rep.
Ger.) V.1-5, 1975-76. Discontinued. Volume(issue)/page/year: 1,1,1975
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 20 mg/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea
Kidney, Ureter, Bladder - urine volume increased
REFERENCE :
MELAAD Medicina del Lavoro. Industrial Medicine. (Via S. Barnaba, 8,
20122
Milan, Italy) V.161925- Volume(issue)/page/year: 30,44,1939
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 76 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher
information, see JFDSAZ. Volume(issue)/page/year: 7,313,1942
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 55 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed.,
Barnes,
C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973
Volume(issue)/page/year: -,53,1973
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Amphibian - frog
DOSE/DURATION
: 910 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 398 mg/kg
TOXIC EFFECTS :
Autonomic Nervous System - other (direct) parasympathomimetic
Behavioral - muscle weakness
Gastrointestinal - nausea or vomiting
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 28(6),45,1984
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 91 mg/kg/26W-I
TOXIC EFFECTS :
Behavioral - alteration of classical conditioning
Blood - changes in leukocyte (WBC) count
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - multiple enzyme effects
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
Volume(issue)/page/year: 45(6),86,1980
V.1-
1936-
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3 gm/kg/10D-I
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Related to Chronic Data - death
Related to Chronic Data - changes in ovarian weight
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert,
Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993.
Discontinued.
Volume(issue)/page/year: 7(5),675,1988
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intratesticular
SPECIES OBSERVED
: Rodent - rat
DOSE
: 16659 ug/kg
SEX/DURATION
: male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book
Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.11960Volume(issue)/page/year: 7,21,1964
** MUTATION DATA **
TYPE OF TEST
: Gene conversion and mitotic recombination
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 14 mmol/L
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year:
1,21,1986
*** REVIEWS ***
ACGIH TLV-TWA 0.5 mg(Ba)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
TOXICOLOGY REVIEW
FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher
information, see JFDSAZ. Volume(issue)/page/year: 7,313,1942
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.5 mg(Ba)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,21,1971
OSHA PEL (Gen Indu):8H TWA 0.5 mg(Ba)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 0.5 mg(Ba)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 0.5 mg(Ba)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 0.5 mg(Ba)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-AUSTRIA: MAK 0.5 mg(Ba)/m3, JAN1999
OEL-AUSTRIA:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-BELGIUM:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-DENMARK: TWA 0.5 mg(Ba)/m3, JAN1999
OEL-FINLAND:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-FRANCE: VME 0.5 mg(Ba)/m3, JAN1999
OEL-GERMANY:TWA 0.5 mg(Ba)/m3 (total dust) JAN 1993
OEL-HUNGARY:STEL 0.5 mg(Ba)/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-THE PHILIPPINES:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-POLAND: MAC(TWA) 0.5 mg(Ba)/m3, MAC(STEL) 1.5 mg(Ba)/m3, JAN1999
OEL-SWEDEN: TWA 0.5 mg(Ba)/m3, JAN1999
OEL-RUSSIA:STEL 0.3 mg/m3 JAN 1993
OEL-SWITZERLAND:TWA 0.5 mg(Ba)/m3;STEL 1 mg(Ba)/m3 JAN 1993
OEL-TURKEY:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 08650
No. of Facilities: 1971 (estimated)
No. of Industries: 46
No. of Occupations: 30
No. of Employees: 13339 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 08650
No. of Facilities: 4299 (estimated)
No. of Industries: 62
No. of Occupations: 62
No. of Employees: 57997 (estimated)
No. of Female Employees: 15249 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE; B subtilis
rec
assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BARIUM FLUORIDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
* Baryum fluorure
:
:
:
:
:
:
:
:
:
CQ9100000
Barium fluoride
7787-32-8
199907
56
Ba-F2
175.34
BA F2
Reproductive Effector
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 250 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
VAMNAQ Vestnik Akademii Meditsinskikh Nauk SSSR. Journal of the Academy
of
Medical Sciences of the USSR. (V/O Mezhdunarodnaya Kniga, 113095 Moscow,
USSR) V.11946- Volume(issue)/page/year: (2),28,1977
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 29910 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DZZEA7 Deutsche Zahnaerztliche Zeitschrift. (Carl Hanser Verlag,
Postfach
860420, D-8000 Munich 86, Fed. Rep. Ger.) V.11946Volume(issue)/page/year: 34,484,1979
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Amphibian - frog
DOSE/DURATION
: 1540 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.11849Volume(issue)/page/year: 124,133,1937
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5660 ug/m3/4H/17W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition
Blood - normocytic anemia
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 22(5),34,1978
** REPRODUCTIVE DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
: TCLo - Lowest published toxic concentration
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 5660 ug/m3/24H
SEX/DURATION
: female 1-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 41(2),109,1976
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 525 mg/kg
SEX/DURATION
: female 1-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
DZZEA7 Deutsche Zahnaerztliche Zeitschrift. (Carl Hanser Verlag,
Postfach
860420, D-8000 Munich 86, Fed. Rep. Ger.) V.11946Volume(issue)/page/year: 34,484,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 656 mg/kg
SEX/DURATION
: female 1-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
DZZEA7 Deutsche Zahnaerztliche Zeitschrift. (Carl Hanser Verlag,
Postfach
860420, D-8000 Munich 86, Fed. Rep. Ger.) V.11946Volume(issue)/page/year: 34,484,1979
*** REVIEWS ***
ACGIH TLV-TWA 0.5 mg(Ba)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 2.5 mg(F)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
TOXICOLOGY REVIEW
AMSSAQ Acta Medica Scandinavica, Supplement. (Almqvist & Wiksell, POB
45150, S-10430 Stockholm, Sweden) No.1-730, 1921-88.
Volume(issue)/page/year: 400,5,1963
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.5 mg(Ba)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,21,1971
OSHA PEL (Gen Indu):8H TWA 0.5 mg(Ba)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Gen Indu):8H TWA 2.5 mg(F)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 0.5 mg(Ba)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Construc):8H TWA 2.5 mg(F)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 0.5 mg(Ba)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Shipyard):8H TWA 2.5 mg(F)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 0.5 mg(Ba)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
OSHA PEL (Fed Cont):8H TWA 2.5 mg(F)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402)
41,50-204.50,1994
Volume(issue)/page/year:
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-AUSTRIA: MAK 0.5 mg(Ba)/m3, JAN1999
OEL-AUSTRIA: MAK 2.5 mg(F)/m3, JAN1999
OEL-AUSTRALIA:TWA 2.5 mg(F)/m3 JAN 1993
OEL-AUSTRIA:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-DENMARK: TWA 0.5 mg(Ba)/m3, JAN1999
OEL-BELGIUM:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-BELGIUM:TWA 2.5 mg(F)/m3 JAN 1993
OEL-FRANCE: VME 0.5 mg(Ba)/m3, JAN1999
OEL-FINLAND:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-POLAND: MAC(TWA) 0.5 mg(Ba)/m3, MAC(STEL) 1.5 mg(Ba)/m3, JAN1999
OEL-FINLAND:TWA 2.5 mg(F)/m3 JAN 1993
OEL-SWEDEN: TWA 0.5 mg(Ba)/m3, JAN1999
OEL-GERMANY:TWA 0.5 mg(Ba)/m3 (total dust) JAN 1993
OEL-GERMANY:TWA 2.5 mg(F)/m3 JAN 1993
OEL-HUNGARY:STEL 0.5 mg(Ba)/m3 JAN 1993
OEL-HUNGARY:TWA 1 mg(F)/m3;STEL 2 mg(F)/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 2.5 mg(F)/m3 JAN 1993
OEL-THE PHILIPPINES:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-THE PHILIPPINES:TWA 2.5 mg(F)/m3 JAN 1993
OEL-RUSSIA:STEL 0.1 mg/m3 JAN 1993
OEL-SWEDEN:TWA 2 mg(F)/m3 JAN 1993
OEL-SWITZERLAND:TWA 0.5 mg(Ba)/m3;STEL 1 mg(Ba)/m3 JAN 1993
OEL-SWITZERLAND:TWA 1.8 ppm (1.5 mg(F)/m3);STEL 9.0 ppm JAN 1993
OEL-THAILAND:TWA 2.5 mg(F)/m3 JAN 1993
OEL-TURKEY:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-TURKEY:TWA 2.5 mg(F)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 2.5 mg(F)/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO FLUORIDES, INORGANIC-air:10H TWA 2.5 mg(F)/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M3299
No. of Facilities: 223 (estimated)
No. of Industries: 6
No. of Occupations: 6
No. of Employees: 1061 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M3299
No. of Facilities: 1341 (estimated)
No. of Industries: 31
No. of Occupations: 14
No. of Employees: 14859 (estimated)
No. of Female Employees: 837 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BARIUM HYDROXIDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
SYNONYMS/TRADE NAMES :
* Barium dihydroxide
* Caustic baryta
:
:
:
:
:
:
:
CQ9200000
Barium hydroxide
17194-00-2
199710
5
Ba-H2-O2
171.36
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 255 mg/kg
TOXIC EFFECTS :
Autonomic Nervous System - other (direct) parasympathomimetic
Behavioral - muscle weakness
Gastrointestinal - nausea or vomiting
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 28(6),45,1984
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 308 mg/kg
TOXIC EFFECTS :
Autonomic Nervous System - other (direct) parasympathomimetic
Behavioral - muscle weakness
Gastrointestinal - nausea or vomiting
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 28(6),45,1984
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 08655
No. of Facilities: 8926 (estimated)
No. of Industries: 89
No. of Occupations: 69
No. of Employees: 108911 (estimated)
No. of Female Employees: 12803 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
BARIUM NITRATE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
:
:
:
:
:
:
:
:
CQ9625000
Barium(II) nitrate (1:2)
10022-31-8
199907
39
N2-O6.Ba
261.36
.BA. N-O3*2
COMPOUND DESCRIPTOR
: Primary Irritant
SYNONYMS/TRADE NAMES :
* Barium dinitrate
* Dusicnan barnaty
* Nitrate de baryum
* Nitric acid, barium salt
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku,"
Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho
Prumyclu
Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,10,1972
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg/24H
REACTION SEVERITY
: Moderate
REFERENCE :
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku,"
Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho
Prumyclu
Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,10,1972
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 355 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku,"
Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho
Prumyclu
Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,10,1972
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 293 mg/kg
TOXIC EFFECTS :
Autonomic Nervous System - other (direct) parasympathomimetic
Behavioral - muscle weakness
Gastrointestinal - nausea or vomiting
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 28(6),45,1984
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AEC-TR-6710
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 16 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
22,150,1972
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku,
Tokyo,
Japan) V.11950- Volume(issue)/page/year: 31,1247,1980
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku,
Tokyo,
Japan) V.11950- Volume(issue)/page/year: 31,1247,1980
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 30 mg/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea
Kidney, Ureter, Bladder - urine volume increased
REFERENCE :
MELAAD Medicina del Lavoro. Industrial Medicine. (Via S. Barnaba, 8,
20122
Milan, Italy) V.161925- Volume(issue)/page/year: 30,44,1939
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 390 mg/kg
TOXIC EFFECTS :
Autonomic Nervous System - other (direct) parasympathomimetic
Behavioral - muscle weakness
Gastrointestinal - nausea or vomiting
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 28(6),45,1984
*** REVIEWS ***
ACGIH TLV-TWA 0.5 mg(Ba)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.5 mg(Ba)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,21,1971
OSHA PEL (Gen Indu):8H TWA 0.5 mg(Ba)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 0.5 mg(Ba)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 0.5 mg(Ba)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 0.5 mg(Ba)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-AUSTRIA: MAK 0.5 mg(Ba)/m3, JAN1999
OEL-AUSTRIA:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-BELGIUM:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-DENMARK: TWA 0.5 mg(Ba)/m3, JAN1999
OEL-FINLAND:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-FRANCE: VME 0.5 mg(Ba)/m3, JAN1999
OEL-GERMANY:TWA 0.5 mg(Ba)/m3 (total dust) JAN 1993
OEL-HUNGARY:STEL 0.5 mg(Ba)/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-THE PHILIPPINES:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-POLAND: TWA 0.5 mg(Ba)/m3, STEL 1.5 mg(Ba)/m3 JAN1999
OEL-SWEDEN: TWA 0.5 mg(Ba)/m3, JAN1999
OEL-RUSSIA:STEL 0.5 mg/m3 JAN 1993
OEL-SWITZERLAND:TWA 0.5 mg(Ba)/m3;STEL 1 mg(Ba)/m3 JAN 1993
OEL-TURKEY:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 81720
No. of Facilities: 542 (estimated)
No. of Industries: 12
No. of Occupations: 13
No. of Employees: 2705 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 81720
No. of Facilities: 600 (estimated)
No. of Industries: 23
No. of Occupations: 26
No. of Employees: 19320 (estimated)
No. of Female Employees: 5165 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BARIUM OXIDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
SYNONYMS/TRADE NAMES :
* Barium monoxide
* Barium protoxide
* Baryta
* Calcined baryta
* Oxyde de baryum
:
:
:
:
:
:
:
:
CQ9800000
Barium oxide
1304-28-5
199907
29
Ba-O
153.34
BA O
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 146 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CUTOEX Current Toxicology. (Nova Science Publishers, Inc., 6080 Jericho
Turnpike, Suite 207, Commack, NY 11725) V.1
1993Volume(issue)/page/year: 1,39,1993
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZVKOA6 Zhurnal Vsesoyuznogo Khimicheskogo Obshchestva im. D.I.
Mendeleeva.
Journal of the D.I. Mendeleeva All-Union Chemical Society. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.51960Volume(issue)/page/year: 19,186,1974
*** REVIEWS ***
ACGIH TLV-TWA 0.5 mg(Ba)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.5 mg(Ba)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,21,1971
OSHA PEL (Gen Indu):8H TWA 0.5 mg(Ba)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 0.5 mg(Ba)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 0.5 mg(Ba)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 0.5 mg(Ba)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-AUSTRIA: MAK 0.5 mg(Ba)/m3, JAN1999
OEL-AUSTRIA:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-BELGIUM:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-DENMARK: TWA 0.5 mg(Ba)/m3, JAN1999
OEL-FINLAND:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-GERMANY:TWA 0.5 mg(Ba)/m3 (total dust) JAN 1993
OEL-HUNGARY:STEL 0.5 mg(Ba)/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-THE PHILIPPINES:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-SWEDEN: TWA 0.5 mg(Ba)/m3, JAN1999
OEL-RUSSIA:STEL 6 mg/m3 JAN 1993
OEL-SWITZERLAND:TWA 0.5 mg(Ba)/m3;STEL 1 mg(Ba)/m3 JAN 1993
OEL-TURKEY:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 80341
No. of Facilities: 218 (estimated)
No. of Industries: 13
No. of Occupations: 16
No. of Employees: 2983 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 80341
No. of Facilities: 913 (estimated)
No. of Industries: 22
No. of Occupations: 28
No. of Employees: 34535 (estimated)
No. of Female Employees: 14944 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BARIUM PERCHLORATE
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
WISWESSER LINE NOTATION :
SYNONYMS/TRADE NAMES :
* Barium diperchlorate
SC7550000
Perchloric acid, barium salt
13465-95-7
199907
23
Cl2-O8.Ba
336.24
.BA..G-O4*2
*** REVIEWS ***
ACGIH TLV-TWA 0.5 mg(Ba)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.5 mg(Ba)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,21,1971
OSHA PEL (Gen Indu):8H TWA 0.5 mg(Ba)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 0.5 mg(Ba)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 0.5 mg(Ba)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 0.5 mg(Ba)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-AUSTRIA:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-BELGIUM:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-FINLAND:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-GERMANY:TWA 0.5 mg(Ba)/m3 (total dust) JAN 1993
OEL-HUNGARY:STEL 0.5 mg(Ba)/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-THE PHILIPPINES:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-SWEDEN: NGV 0.5 mg(Ba)/m3, JAN1999
OEL-SWITZERLAND:TWA 0.5 mg(Ba)/m3;STEL 1 mg(Ba)/m3 JAN 1993
OEL-TURKEY:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.5 mg(Ba)/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84801
No. of Facilities: 47 (estimated)
No. of Industries: 2
No. of Occupations: 2
No. of Employees: 452 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BARIUM SULFATE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
OTHER CAS REGISTRY NOS.
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
SYNONYMS/TRADE NAMES :
* Actybaryte
* Artificial barite
* Artificial heavy spar
* BA147
* Bakontal
* Baridol
* Barite
* Baritop
* Barium sulfate (1:1)
* Barium sulfate
* Barium sulphate
* Barosperse
* Barotrast
* Baryta White
* Barytes
* Barytes 22
CR0600000
Barium sulfate
7727-43-7
12751-32-5
199907
27
O4-S.Ba
233.40
.BA..S-O4
Tumorigen
Drug
Mutagen
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
Bayrites
Blanc fixe
C.I. 77120
C.I. Pigment White 21
Citobaryum
Colonatrast
Enamel White
Esophotrast
Eweiss
E-Z-Paque
Finemeal
Lactobaryt
Liquibarine
Macropaque
Neobar
Oratrast
Permanent White
Precipitated barium sulphate
Raybar
Redi-Flow
Solbar
Sulfuric acid, barium salt (1:1)
Supramike
Travad
Unibaryt
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Intratracheal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >600 uL/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.11967- Volume(issue)/page/year: 50,123,1995
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intrapleural
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.11947Volume(issue)/page/year:
28,173,1973
** MUTATION DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
: Micronucleus test
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 12500 ug/kg
REFERENCE :
GWZHEW Gongye Weisheng Yu Zhiyebing. Industrial Health and Occupational
Diseases. (China International Book Trading Corp., POB 2820, Beijing,
Peop.
Rep. China) V.11973- Volume(issue)/page/year: 12,77,1986
*** REVIEWS ***
ACGIH TLV-TWA 10 mg/m3, Inhalable particulate
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
TOXICOLOGY REVIEW
31BYAP "Experimental Lung Cancer: Carcinogenesis and Bioassays,
International Symposium, 1974," Karbe, E., and J.F. Park, eds.,
Springer-Verlag New York, Inc., 1974 Volume(issue)/page/year: -,94,1974
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.5 mg(Ba)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,21,1971
OSHA PEL (Gen Indu):8H TWA 15 mg/m3, total dust
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Gen Indu):8H TWA 5 mg/m3, respirable fraction
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 15 mg/m3, total dust
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Construc):8H TWA 5 mg/m3, respirable fraction
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 15 mg/m3, total dust
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Shipyard):8H TWA 5 mg/m3, respirable fraction
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 10 mg/m3 JAN 1993
OEL-AUSTRIA: MAK 0.5 mg(Ba)/m3, JAN1999
OEL-BELGIUM:TWA 10 mg/m3 (resp. dust) JAN 1993
OEL-UNITED KINGDOM:TWA 2 mg/m3 JAN 1993
OEL-DENMARK: TWA 0.5 mg(Ba)/m3, JAN1999
OEL-SWEDEN: TWA 0.5 mg(Ba)/m3, JAN1999
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO BARIUM SULFATE, respirable fraction-air:10H TWA 5 mg/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO BARIUM SULFATE, total dust-air:10H TWA 10 mg/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 80611
No. of Facilities: 18620 (estimated)
No. of Industries: 173
No. of Occupations: 104
No. of Employees: 188781 (estimated)
NOES - National Occupational
NOES Hazard Code - 80611
No. of Facilities: 25446
No. of Industries: 200
No. of Occupations: 133
No. of Employees: 363169
No. of Female Employees:
Exposure Survey (1983)
(estimated)
(estimated)
96327 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
BASIC FUCHSIN
RTECS NUMBER
CHEMICAL NAME
: CX9850100
: Benzenamine,
4-((4-aminophenyl)(4-imino-2,5-cyclohexadien-1-yliden
e)methyl), monohydrochloride
CAS REGISTRY NUMBER
: 569-61-9
OTHER CAS REGISTRY NOS. : 70426-60-7
131883-55-1
LAST UPDATED
: 199904
DATA ITEMS CITED
: 36
MOLECULAR FORMULA
: C19-H17-N3.Cl-H
MOLECULAR WEIGHT
: 323.85
WISWESSER LINE NOTATION : L6Y DHJ AUM DYR DZ&R DZ
COMPOUND DESCRIPTOR
: Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* Basic parafuchsine
* Basic Red 9
* Basic Rubine
* Calcozine magenta N
* Cerven zasadita 9
* C.I. 42500
* C.I. Basic Red 9, monohydrochloride
* p-Fuchsin
* Fuchsine DR-001
* Fuchsine SP
* Fuchsine SPC
* Fuchsin SP
* 4,4'-((4-Imino-2,5-cyclohexadien-1-ylidene)methylene)dianiline
monohydrochloride
* NCI-C54739
* Orient Paramagenta Base
* Parafuchsin
* Parafuchsine
* para-Magenta
* Pararosaniline
* Pararosaniline chloride
* Pararosaniline hydrochloride
* p-Rosaniline HCl
* Schultz-tab. No. 779
* 4,4'4''-Triaminotriphenylmethan-hydrochlorid
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug
Research.
(Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way,
Secaucus, NJ 07094) V.11959- Volume(issue)/page/year: 17,108,1973
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 18200 mg/kg/13W-C
TOXIC EFFECTS :
Endocrine - thyroid weight (goiter)
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-285,1986
(Research
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 728 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
Endocrine - thyroid tumors
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-285,1986
(Research
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1714 mg/kg/43W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
NATWAY Naturwissenschaften. (Springer-Verlag, Heidelberger Platz 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.11913- Volume(issue)/page/year:
43,543,1956
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 364 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
Endocrine - adrenal cortex tumors
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-285,1986
(Research
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 100 ug/plate
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 6(Suppl
2),1,1984
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 20 mg/L
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 62,873,1979
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human HeLa cell
DOSE/DURATION
: 300 umol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 13,2389,1992
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - rat Embryo
DOSE/DURATION
: 1400 ug/L
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 67,1303,1981
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 2200 ug/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 5,482,1983
TYPE OF TEST
: Body fluid assay
TEST SYSTEM
: Rodent - rat Bacteria - Salmonella typhimurium
DOSE/DURATION
: 1680 mg/kg/2W (Continuous)
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 9,69,1987
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
: Mutation in microorganisms
: Rodent - mouse Lymphocyte
: 41 mg/L
EMMUEG Environmental and Molecular Mutagenesis.
(Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003)
12(Suppl 13),37,1988
V.10-
1987-
Volume(issue)/page/year:
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - mouse Fibroblast
DOSE/DURATION
: 8 ug/L
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 67,1303,1981
TYPE OF TEST
: Body fluid assay
TEST SYSTEM
: Rodent - mouse Bacteria - Salmonella typhimurium
DOSE/DURATION
: 840 mg/kg/1W (Continuous)
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 9,69,1987
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 1020 ug/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
12(Suppl 13),37,1988
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - hamster Liver
DOSE/DURATION
: 10 umol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 6,1,1984
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Mammal - species unspecified Lymphocyte
DOSE/DURATION
: 10 pph
REFERENCE :
BIPMAA Biopolymers. (John Wiley & Sons, Inc., 605 Third Ave., New York,
NY
10158) V.11963- Volume(issue)/page/year: 11,2537,1972
*** REVIEWS ***
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 57,215,1993
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 4,57,1974
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 4,57,1974
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 57,215,1993
IARC Cancer Review:Group 2B
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 57,215,1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M1440
No. of Facilities: 148 (estimated)
No. of Industries: 4
No. of Occupations: 6
No. of Employees: 494 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M1440
No. of Facilities: 165 (estimated)
No. of Industries: 4
No. of Occupations: 6
No. of Employees: 907 (estimated)
No. of Female Employees: 733 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9
EPA GENETOX PROGRAM 1988, Positive/dose response: Cell
transform.-BALB/c-3T3
EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Negative: Host-mediated assay; Histidine
reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Inconclusive: SHE-clonal assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NTP Carcinogenesis Studies (feed);clear evidence:mouse,rat
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-285,1986
(Research
NTP 8th Annual Report on Carcinogens, 1998:Reasonably Anticipated to be
Human Carcinogen
BASIC FUCHSIN HYDROCHLORIDE
RTECS NUMBER
: CX9850000
CHEMICAL NAME
: Benzenamine,
4-((4-aminophenyl)(4-imino-2,5-cyclohexadien-1-yliden
e)methyl)-2-methyl-, monohydrochloride
CAS REGISTRY NUMBER
: 632-99-5
OTHER CAS REGISTRY NOS. : 8053-09-6
LAST UPDATED
: 199701
DATA ITEMS CITED
: 10
MOLECULAR FORMULA
: C20-H19-N3.Cl-H
MOLECULAR WEIGHT
: 337.88
WISWESSER LINE NOTATION : L6Y DYJ AUYR DZ&R DZ C1& DUM &GH
COMPOUND DESCRIPTOR
: Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* Aizen magenta
*
4-((4-Aminophenyl)(4-imino-2,5-cyclohexadien-1-ylidene)methyl)-2-methylb
enzenamine HCl
* Astra fuchsine B
* Basic fuchsin
* Basic fuchsine
* Basic magenta
* Basic magenta E-200
* Basic Violet 14
* Calcozine fuchsine HO
* Calcozine Magenta RTN
* Calcozine magenta XX
* Cerise B
* C.I. 42510
* C.I. Basic Violet 14
* C.I. Basic Violet 14, monohydrochloride
* C-WR Violet 8
* Diabasic magenta
* Diamond fuchsine
* Fuchsin
* Fuchsine
* Fuchsine A
* Fuchsine CS
* Fuchsine G
* Fuchsine HO
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
Fuchsine N
Fuchsine RTN
Fuchsine SBP
Fuchsine Y
Magenta
Magenta DP
Magenta E
Magenta G
Magenta I
Magenta PN
Magenta powder N
Magenta S
Magenta Super Fine
Orient basic magenta
12418 Red
Rosaniline
Rosaniline chloride
Rosaniline hydrochloride
Rosanilinium chloride
Violet zasadita 14
*** HEALTH HAZARD DATA ***
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 32 ug/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
89,21,1981
*** REVIEWS ***
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 4,57,1974
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 4,57,1974
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 57,215,1993
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979-
Volume(issue)/page/year:
7,238,1987
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84118
No. of Facilities: 651 (estimated)
No. of Industries: 11
No. of Occupations: 19
No. of Employees: 5303 (estimated)
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84405
No. of Facilities: 719 (estimated)
No. of Industries: 4
No. of Occupations: 6
No. of Employees: 4356 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84118
No. of Facilities: 1281 (estimated)
No. of Industries: 6
No. of Occupations: 15
No. of Employees: 12691 (estimated)
No. of Female Employees: 8288 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BATHOPHENANTHROLINE
RTECS NUMBER
: SF8427000
CHEMICAL NAME
: 1,10-Phenanthroline, 4,7-diphenylCAS REGISTRY NUMBER
: 1662-01-7
BEILSTEIN REFERENCE NO. : 0261048
REFERENCE
: 5-23-10-00274 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 4
MOLECULAR FORMULA
: C24-H16-N2
MOLECULAR WEIGHT
: 332.42
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Bathophenanthrolin
* 1,10-Bathophenanthroline
* 4,7-Diphenyl-1,10-phenanthroline
*** HEALTH HAZARD DATA ***
** MUTATION DATA **
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - mouse Cells - not otherwise specified
DOSE/DURATION
: 440 ug/L
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 35,1209,1985
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M0594
No. of Facilities: 28 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 700 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M0594
No. of Facilities: 9 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 249 (estimated)
No. of Female Employees: 171 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BBOT
RTECS NUMBER
CHEMICAL NAME
: DM4888332
: Benzoxazole,
2,2'-(2,5-thiophenediyl)bis(5-(1,1-dimethylethyl): 7128-64-5
: 199803
: 4
: C26-H26-N2-O2-S
: 430.60
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
SYNONYMS/TRADE NAMES :
* BBOT
* BBOT 150
* Benzoxazole, 2,2'-(2,5-thiophenediyl)bis(5-tert-butyl* 2,5-Bis(5-tert-butylbenzoxazol-2-yl)thiophene
* Uvitex OB
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MVCRB3 MVC-Report. (Stockholm, Sweden)
Volume(issue)/page/year: 2,193,1973
No.1-2, 1972-73.
Discontinued.
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 54600 mg/kg/2Y-C
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0539835
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
BEMEGRIDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
MA4550000
Glutarimide, 3-ethyl-3-methyl64-65-3
0116672
5-21-09-00601 (Beilstein Handbook Reference)
199701
16
C8-H13-N-O2
155.22
T6VMVTJ E2 E1
Drug
Human
SYNONYMS/TRADE NAMES :
* Ahypnon
* Bemegrid
* Bemegride
* Bemigride
* Benegrid
* 2,6-Dioxo-4-methyl-4-ethylpiperidine
* 4-Ethyl-4-methyl-2,6-dioxopiperidine
* beta-Ethyl-beta-methylglutarimide
* 3-Ethyl-3-methylglutarimide
* 4-Ethyl-4-methyl-2,6-piperidinedione
* Eukraton
* Malysol
* Megimid
* Megimide
* 4-Methyl-4-ethyl-2,6-dioxopiperidine
* beta-Methyl-beta-ethylglutarimide
* 3-Methyl-3-ethylglutarimide
* Mikedimide
* NP13
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Behavioral - wakefulness
Behavioral - hallucinations, distorted perceptions
Behavioral - toxic psychosis
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1Volume(issue)/page/year: 2,967,1956
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 20 mg/kg
TOXIC EFFECTS :
Behavioral - wakefulness
Behavioral - hallucinations, distorted perceptions
Behavioral - toxic psychosis
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1Volume(issue)/page/year: 2,967,1956
1823-
1823-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 24 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 135,9,1962
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 31 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of
Great
Britain, 1 Lambeth High St., London SEI 7JN, UK) V.11949Volume(issue)/page/year: 13,244,1961
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Intravenous
Rodent - rat
16 mg/kg
V.4-
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 135,9,1962
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 41 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
V.4-
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 128,176,1960
V.1-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 25 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
1909/10-
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 128,176,1960
V.1-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 27 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
1909/10-
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 128,176,1960
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 16 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Behavioral - muscle contraction or spasticity
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 110,29,1957
V.4-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 33 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,763,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 32 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 6,583,1956
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 23 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 135,9,1962
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 1080 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 110,465,1957
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - gerbil
DOSE/DURATION
: 22 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
V.4-
V.4-
V.4-
1898-
Volume(issue)/page/year: 225,88,1977
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - gerbil
DOSE/DURATION
: 22500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 227,106,1977
V.4-
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BENTONITE
RTECS NUMBER
: CT9450000
CHEMICAL NAME
: Bentonite
CAS REGISTRY NUMBER
: 1302-78-9
OTHER CAS REGISTRY NOS. : 11004-12-9
LAST UPDATED
: 199907
DATA ITEMS CITED
: 11
WISWESSER LINE NOTATION : .AL2.SI4.C10.Q2.QH#
COMPOUND DESCRIPTOR
: Tumorigen
SYNONYMS/TRADE NAMES :
* Albagel Premium USP 4444
* Bentonite 2073
* Bentonite magma
* HI-Jel
* Imvite I.G.B.A
* Magbond
* Montmorillonite
* Panther creek bentonite
* Southern bentonite
* Tixoton
* Volcaly bentonite BC
* Volclay
* Wilkinite
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 35 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - acute pulmonary edema
REFERENCE :
BSIBAC Bolletino della Societe Italiana di Biologia Sperimentale. (Casa
Editrice Idelson, Via A. de Gasperi, 55, 80133 Naples, Italy) V.2- 1927-
Volume(issue)/page/year: 44,1685,1968
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 10 mg/kg
TOXIC EFFECTS :
Vascular - thrombosis distant from injection site
REFERENCE :
JCINAO Journal of Clinical Investigation. (Rockefeller Univ. Press, 1230
York Ave., New York, NY 10021) V.11924- Volume(issue)/page/year:
42,860,1963
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 12000 gm/kg/28W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
REFERENCE :
ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of
Sciences, 2 E. 63rd St., New York, NY 10021) V.11877Volume(issue)/page/year: 57,678,1954
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 90340
No. of Facilities: 22741 (estimated)
No. of Industries: 169
No. of Occupations: 130
No. of Employees: 286502 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X1608
No. of Facilities: 70 (estimated)
No. of Industries: 3
No. of Occupations: 3
No. of Employees: 1732 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X9436
No. of Facilities: 171 (estimated)
No. of Industries: 2
No. of Occupations: 4
No. of Employees: 6525 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X9494
No. of Facilities: 115 (estimated)
No. of Industries: 4
No. of Occupations: 3
No. of Employees: 11850 (estimated)
No. of Female Employees: 11045 (estimated)
NOES - National Occupational
NOES Hazard Code - 90340
No. of Facilities: 31430
No. of Industries: 212
No. of Occupations: 147
No. of Employees: 545795
No. of Female Employees:
Exposure Survey (1983)
(estimated)
(estimated)
36750 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NTP Carcinogenesis studies; selected, May 1999
BENZ(E)ACEPHENANTHRYLENE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
CU1400000
Benz(e)acephenanthrylene
205-99-2
1872553
4-05-00-02686 (Beilstein Handbook Reference)
199907
33
C20-H12
252.32
L C65 K666 1A TJ
Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* 3,4-Benz(e)acephenanthrylene
* 2,3-Benzfluoranthene
* 3,4-Benzfluoranthene
* Benzo(b)fluoranthene
* Benzo(b)fluoranthene
* Benzo(e)fluoranthene
* 2,3-Benzofluoranthene
* 3,4-Benzofluoranthene
* 2,3-Benzofluoranthrene
* B(b)F
*** HEALTH HAZARD DATA ***
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Implant
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Tumorigenic - tumors at site of application
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 71,539,1983
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 88 ng/kg/120W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Skin and Appendages - tumors
Tumorigenic - tumors at site of application
REFERENCE :
ARGEAR Archiv fuer Geschwulstforschung. (VEB Verlag Volk und Gesundheit
Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.11949Volume(issue)/page/year: 50,266,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 5046 ug/kg/15D-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11975- Volume(issue)/page/year:
34,15,1987
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 72 mg/kg/9W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
AICCA6 Acta Unio Internationalis Contra Cancrum. (Louvain, Belgium)
V.1-20,
1936-64. For publisher information, see IJCNAW. Volume(issue)/page/year:
19,490,1963
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 72 mg/kg/60W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
Tumorigenic - tumors at site of application
REFERENCE :
CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment
Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.11948Volume(issue)/page/year: 12,1194,1959
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TD - Toxic dose (other than lowest)
Implant
Rodent - rat
5 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Tumorigenic - tumors at site of application
REFERENCE :
50NNAZ "Polynuclear Aromatic Hydrocarbons, International Symposium, 7th,
1982," Cooke, M., and A.J. Dennis, eds., Columbus, OH, Battelle Press,
1983
Volume(issue)/page/year: 7,571,1983
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 4037 ug/kg/20D-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 6,1023,1985
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 31 nmol/plate
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 6,1023,1985
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 3 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
419,91,1998
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 55 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
371,123,1996
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 100 mg/kg
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
17(Suppl 19),13,1991
TYPE OF TEST
: DNA adduct
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 100 mg/kg
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 13,1731,1992
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 3 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
419,91,1998
TYPE OF TEST
: Sister chromatid exchange
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 100 mg/kg
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
17(Suppl 19),13,1991
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 100 ug/L
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 17,149,1980
TYPE OF TEST
: Sister chromatid exchange
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - hamster
DOSE/DURATION
: 900 mg/kg/24H
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
66,65,1979
*** REVIEWS ***
ACGIH TLV-Suspected human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 3,69,1973
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 32,147,1983
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 32,147,1983
IARC Cancer Review:Group 2B
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,56,1987
TOXICOLOGY REVIEW
ACRSAJ Advances in Cancer Research. (Academic Press, Inc., 465 S.
Lincoln
Dr., Troy, MO 63379) V.11953- Volume(issue)/page/year: 7,475,1963
TOXICOLOGY REVIEW
85DHAX "Medical and Biologic Effects of Environmental Pollutants Series,"
Washington, DC, National Academy of Sciences, 1972-77
Volume(issue)/page/year: Pc,4,1972
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRIA: Carcinogen, JAN1999
OEL-GERMANY;Carcinogen JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - E0466
No. of Facilities: 142 (estimated)
No. of Industries: 3
No. of Occupations: 3
No. of Employees: 2283 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Inconclusive: In vivo SCE-nonhuman
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Polynuclear aromatic hydrocarbons by HPLC,
5506; by GC, 5515
NTP 8th Annual Report on Carcinogens, 1998:Reasonably Anticipated to be
Human Carcinogen
BENZALACETOPHENONE
RTECS NUMBER
: FL6900000
CHEMICAL NAME
: Chalcone
CAS REGISTRY NUMBER
: 94-41-7
LAST UPDATED
: 199706
DATA ITEMS CITED
: 5
MOLECULAR FORMULA
: C15-H12-O
MOLECULAR WEIGHT
: 208.27
WISWESSER LINE NOTATION : RV1U1R
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Acrylophenone, 3-phenyl* Benzalacetophenone
* 2-Benzalacetophenone
* 1-Benzoyl-1-phenylethene
* beta-Benzoylstyrene
* alpha-Benzylideneacetophenone
* 2-Benzylideneacetophenone
* Chalkone
* Cinnamophenone
* 1,3-Diphenylpropenone
* 1,3-Diphenyl-1-propen-3-one
* beta-Phenylacrylophenone
* 3-Phenylacrylophenone
* 1-Phenyl-2-benzoylethylene
* Phenyl 2-phenylvinyl ketone
* Phenyl styryl ketone
* 2-Propen-1-one, 1,3-diphenyl* Styryl phenyl ketone
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCNSA6 National Academy of Sciences, National Research Council,
Chemical-Biological Coordination Center, Review. (Washington, DC)
Volume(issue)/page/year: 5,28,1953
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 681 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IJSBDB Indian Journal of Chemistry, Section B: Organic Chemistry,
Including
Medicinal Chemistry. (Publications & Information Directorate, Council of
Scientific and Industrial Research (CSIR), Hillside Rd., New Delhi 110
012,
India) V.14B1976- Volume(issue)/page/year: 18,65,1979
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 56 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD
21010)
Volume(issue)/page/year: NX#04476
** MUTATION DATA **
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Rodent - mouse Cells - not otherwise specified
DOSE/DURATION
: 250 units/L
REFERENCE :
ECREAL Experimental Cell Research. (Academic Press, Inc., 1 E. First
St.,
Duluth, MN 55802) V.101950- Volume(issue)/page/year: 35,629,1964
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BENZALDEHYDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
CU4375000
Benzaldehyde
100-52-7
199907
36
C7-H6-O
106.13
VHR
Agricultural Chemical
Tumorigen
Drug
Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* Almond artificial essential oil
* Artificial almond oil
* Artificial essential oil of almond
* Benzaldehyde FFC
* Benzene carbaldehyde
* Benzenecarbonal
* Benzoic aldehyde
* NCI-C56133
* Phenylmethanal
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Moderate
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 14,693,1976
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1300 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - coma
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 2,327,1964
TYPE OF TEST
: LC - Lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >500 mg/m3
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - conjunctive irritation
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - other changes
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 18(11),40,1974
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5 gm/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory depression
Lungs, Thorax, or Respiration - other changes
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 27,163,1922
V.4-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 28 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - tremor
Lungs, Thorax, or Respiration - other changes
REFERENCE :
EJTXAZ European Journal of Toxicology and Environmental Hygiene.
France) V.7-9, 1974-76. For publisher information, see TOERD9.
Volume(issue)/page/year: 9,99,1976
(Paris,
TYPE OF TEST
: LC - Lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >500 mg/m3
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - conjunctive irritation
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - other changes
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 18(11),40,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 9 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - tremor
Lungs, Thorax, or Respiration - other changes
REFERENCE :
EJTXAZ European Journal of Toxicology and Environmental Hygiene.
France) V.7-9, 1974-76. For publisher information, see TOERD9.
Volume(issue)/page/year: 9,99,1976
(Paris,
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 14,693,1976
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 1 gm/kg
TOXIC EFFECTS :
Behavioral - tremor
Gastrointestinal - ulceration or bleeding from small intestine
Kidney, Ureter, Bladder - urine volume increased
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 2,327,1964
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 2020 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 39(4),86,1974
(V/O
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 9600 mg/kg/16D-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-378,1990
(Research
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 52 gm/kg/13W-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Liver - fatty liver degeneration
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-378,1990
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 500 ppm/6H/14D-C
TOXIC EFFECTS :
Liver - changes in liver weight
Blood - changes in other cell count (unspecified)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
52,503,1991
TYPE OF TEST
ROUTE OF EXPOSURE
: TCLo - Lowest published toxic concentration
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 26 mg/m3/5H/17W-I
TOXIC EFFECTS :
Blood - changes in erythrocyte (RBC) count
Blood - changes in leukocyte (WBC) count
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 18(11),40,1974
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 9600 mg/kg/16D-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-378,1990
(Research
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 78 gm/kg/13W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-378,1990
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 154 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Gastrointestinal - tumors
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-378,1990
(Research
** MUTATION DATA **
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 1 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
206,17,1988
TYPE OF TEST
: Specific locus test
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 400 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
17,196,1991
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 400 mg/L
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-378,1990
(Research
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 1 gm/L
REFERENCE :
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic
Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu,
Setagaya-ku, Tokyo 158, Japan) V.11886- Volume(issue)/page/year:
(103),64,1985
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 50 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
10(Suppl 10),1,1987
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-HUNGARY:TWA 5 mg/m3;STEL 10 mg/m3 JAN 1993
OEL-RUSSIA:STEL 5 mg/m3 JAN 1993
OEL-POLAND: TWA 10 mg/m3, STEL 40 mg/m3, JAN1999
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84494
No. of Facilities: 1409 (estimated)
No. of Industries: 18
No. of Occupations: 43
No. of Employees: 15976 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84494
No. of Facilities: 3776 (estimated)
No. of Industries: 31
No. of Occupations: 58
No. of Employees: 67721 (estimated)
No. of Female Employees: 27021 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: N crassa-reversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1996: Volatile organic compound, 2549
NTP Carcinogenesis Studies (gavage);some evidence:mouse
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-378,1990
NTP Carcinogenesis Studies (gavage);no evidence:rat
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-378,1990
BENZALKONIUM CHLORIDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
OTHER CAS REGISTRY NOS.
:
:
:
:
LAST UPDATED
DATA ITEMS CITED
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
(Research
(Research
BO3150000
Ammonium, alkyldimethylbenzyl-, chloride
8001-54-5
8011-91-4
8039-63-2
12741-06-9
8036-90-6
8045-21-4
59890-14-1
75635-12-0
39434-18-9
199801
25
AK1&1&1R &G
Agricultural Chemical
Drug
Mutagen
Reproductive Effector
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* Alkyl dimethylbenzyl ammonium chloride
* Alkyldimethyl(phenylmethyl)quaternary ammonium chlorides
* Ammonyx
* Arquad dmmcb-75
* Barquat MB-50
* Bayclean
* Benirol
* Benzalkonium A
* Benzalkonium chloride
* Bionol
* Bio-quat 50-24
* Bio-quat 50-25
* Bio-quat 50-30
* Bio-quat 50-40
* Bio-quat 50-42
* Bio-quat 50-60
* Bio-quat 50-65
* Bio-quat 80-24
* Bio-quat 80-28
* Bio-quat 80-40
* Bio-quat 80-42
* BTC
* BTC 50
* BTC 65
* BTC 100
* BTC 824
* BTC 2565
* BTC 8248
* BTC 8249
* BTC E-8358
* BTC 50 USP
* BTC 65 USP
* Cequartyl
* Culversan LC 80
* Dimanin A
* Dodigen 226
* Drapolene
* Drapolex
* Enuclen
* Gardiquat 1450
* Gardiquart SV480
* Genamin KDS
* Germicin
* Germitol
* Intexan LB-50
* Kemamine BAC
* Marinol
* Mefarol
* Neo Germ-I-tol
* Onyx BTC (Onyx oil & chem Co)
* Osvan
* Paralkan
* Pheneene germicidal solution and tincture
* Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides
* Quaternium-1
* Romergal CB
* Triton K-60
* Vikrol RQ
* Zephiral
* Zephiran chloride
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Human
DOSE/DURATION
: 150 ug/3D (Intermittent)
REACTION SEVERITY
: Mild
REFERENCE :
85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976,"
Drill,
V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977
Volume(issue)/page/year: -,127,1977
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Human
DOSE/DURATION
: 50 ug
REACTION SEVERITY
: Severe
REFERENCE :
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N.
Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.11918Volume(issue)/page/year: 27,1118,1944
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Primate - monkey
DOSE/DURATION
: 2 mg/24H
REACTION SEVERITY
: Severe
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
6,701,1964
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 50 mg/24H
REACTION SEVERITY
: Moderate
REFERENCE :
33NFA8 "Animal Models in Dermatology: Relevance to Human
Dermatopharmacology
and Dermatotoxicology," Maibach, H., ed., New York, Churchill Livingston,
1975 Volume(issue)/page/year: -,2,1975
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 ug
REFERENCE :
AROPAW Archives of Ophthalmology (Chicago). (AMA, 535 N. Dearborn St.,
Chicago, IL 60610) New series: V.1-44(3), 1929-50; V.641960Volume(issue)/page/year: 34,99,1945
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1 mg/24H
REACTION SEVERITY
: Severe
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
6,701,1964
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 10 mg
REACTION SEVERITY
: Mild
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
55,501,1980
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 266 mg/kg
TOXIC EFFECTS :
Behavioral - hallucinations, distorted perceptions
Gastrointestinal - changes in structure or function of esophagus
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
HUTODJ Human Toxicology. (Macmillan Press Ltd., Houndmills, Basingstoke,
Hants., RG 21 2XS, UK) V.11981- Volume(issue)/page/year: 7,191,1988
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 240 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Gastrointestinal - nausea or vomiting
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.11960Volume(issue)/page/year: 4,219,1970
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 14500 ug/kg
TOXIC EFFECTS :
Behavioral - ataxia
Lungs, Thorax, or Respiration - dyspnea
Gastrointestinal - ulceration or bleeding from small intestine
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.11960Volume(issue)/page/year: 4,219,1970
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 400 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.11960Volume(issue)/page/year: 4,219,1970
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 13900 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.11960Volume(issue)/page/year: 4,219,1970
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 64 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.11960Volume(issue)/page/year: 4,219,1970
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 274 gm/kg/2Y-C
TOXIC EFFECTS :
Behavioral - food intake (animal)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific
Edition. (Washington, DC) V.29-49, 1940-60. For publisher information,
see
JPMSAE. Volume(issue)/page/year: 40,263,1951
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 13125 mg/kg/15W-C
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific
Edition.
(Washington, DC) V.29-49, 1940-60.
For publisher information,
see
JPMSAE.
Volume(issue)/page/year: 40,263,1951
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravaginal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 50 mg/kg
SEX/DURATION
: female 1 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter;
measured
before birth)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd.,
Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.11981Volume(issue)/page/year: 5,398,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravaginal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 100 mg/kg
SEX/DURATION
: female 1 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd.,
Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.11981Volume(issue)/page/year: 5,398,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravaginal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 200 mg/kg
SEX/DURATION
: female 1 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora
lutea)
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd.,
Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.11981Volume(issue)/page/year: 5,398,1985
** MUTATION DATA **
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
: DNA repair
: Bacteria - Bacillus subtilis
: 50 ug/L
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
193,21,1988
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 1 mg/L
REFERENCE :
SHIGAZ Shigaku. Ondotology. (Nippon Shika Daigaku Shigakkai, 1-9-20
Fujimi, Chiyodaku, Tokyo 102, Japan) V.381949Volume(issue)/page/year: 74,1365,1987
*** REVIEWS ***
TOXICOLOGY REVIEW
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
32,245,1974
TOXICOLOGY REVIEW
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert,
Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993.
Discontinued.
Volume(issue)/page/year: 8(4),589,1989
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - T1554
No. of Facilities: 1244 (estimated)
No. of Industries: 23
No. of Occupations: 13
No. of Employees: 52380 (estimated)
NOES - National Occupational
NOES Hazard Code - T1554
No. of Facilities: 18923
No. of Industries: 125
No. of Occupations: 80
No. of Employees: 486761
No. of Female Employees:
BENZAMIDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
Exposure Survey (1983)
(estimated)
(estimated)
309834 (estimated)
: CU8700000
: Benzamide
: 55-21-0
OTHER CAS REGISTRY NOS. : 27208-38-4
BEILSTEIN REFERENCE NO. : 0385876
REFERENCE
: 4-09-00-00725 (Beilstein Handbook Reference)
LAST UPDATED
: 199709
DATA ITEMS CITED
: 13
MOLECULAR FORMULA
: C7-H7-N-O
MOLECULAR WEIGHT
: 121.15
WISWESSER LINE NOTATION : ZVR
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Amid kyseliny benzoove
* Benzenecarboxamide
* Benzoic acid amide
* Benzoylamide
* Phenylcarboxamide
* Phenylcarboxyamide
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 781 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - acute pulmonary edema
REFERENCE :
APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353
Vineuil,
France) V.11943- Volume(issue)/page/year: 48,23,1990
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1160 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
19,20,1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1282 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - acute pulmonary edema
REFERENCE :
APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353
Vineuil,
France) V.11943- Volume(issue)/page/year: 48,23,1990
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation).
Translation
of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)
1967- Volume(issue)/page/year: 28,335,1994
No.1-
** MUTATION DATA **
TYPE OF TEST
: Phage inhibition capacity
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 15500 ng/well
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
260,349,1991
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 300 umol/L
REFERENCE :
NULSAK Nucleus (Calcutta). (Dr. A.K. Sharma, Centre of Advanced Studies
in
Cell and Chromosome Research, Calcutta, 35 Baliygunge Circular Rd.,
Calcutta
700 019, India) V.11958- Volume(issue)/page/year: 28,198,1985
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 1650 umol/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
192,141,1987
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - mouse Leukocyte
DOSE/DURATION
: 1 mmol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 8,1185,1987
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 1 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
126,63,1984
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
: Micronucleus test
: Mammal - species unspecified Kidney
: 1000 ppm
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications &
Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1Volume(issue)/page/year: 18,329,1980
1963-
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Mammal - species unspecified Kidney
DOSE/DURATION
: 1000 ppm/8H
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications &
Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.11963Volume(issue)/page/year: 18,329,1980
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Mammal - species unspecified Kidney
DOSE/DURATION
: 1000 ppm
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications &
Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1Volume(issue)/page/year: 18,329,1980
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BENZAMIDINE HYDROCHLORIDE HYDRATE
RTECS NUMBER
: CV6260000
CHEMICAL NAME
: Benzamidine, hydrochloride
CAS REGISTRY NUMBER
: 1670-14-0
LAST UPDATED
: 199701
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C7-H8-N2.Cl-H
MOLECULAR WEIGHT
: 156.63
WISWESSER LINE NOTATION : ZYR&UM &GH
SYNONYMS/TRADE NAMES :
* Amidinobenzene hydrochloride
* Benzamidinium chloride
* Benzenecarboximidamide hydrochloride
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 580 mg/kg
TOXIC EFFECTS :
Brain and Coverings - meningeal changes
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - other changes
REFERENCE :
1963-
BIREBV Biology of Reproduction.
(Soc. for the Study of Reproduction, 309
Clark St., Champaign, IL 61820)
20,1045,1979
V.1-
W.
1969-
Volume(issue)/page/year:
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BENZANTHRACENE (1,2-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
CV9275000
Benz(a)anthracene
56-55-3
199904
85
C18-H12
228.30
L D6 B666J
Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* Benzanthracene
* 1,2-Benzanthracene
* 1,2-Benz(a)anthracene
* 1,2-Benzanthrazen
* Benzanthrene
* 1,2-Benzanthrene
* Benzo(a)anthracene
* 1,2-Benzoanthracene
* Benzo(b)phenanthrene
* 2,3-Benzophenanthrene
* 2,3-Benzphenanthrene
* Naphthanthracene
* RCRA waste number U018
* Tetraphene
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MOPMA3 Molecular Pharmacology. (Williams & Wilkins Co., 428 E. Preston
St.,
Baltimore, MD 21202) V.11965- Volume(issue)/page/year: 4,427,1968
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LDLo - Lowest published lethal dose
Intravenous
Rodent - mouse
10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC)
V.1-60,
1940-78. For publisher information, see JJIND8.
Volume(issue)/page/year:
1,225,1940
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 18 mg/kg
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
38,1699,1978
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
15,632,1955
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Implant
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 80 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Kidney, Ureter, Bladder - tumors
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.11947Volume(issue)/page/year:
22,825,1968
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 18 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
38,1705,1978
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 360 mg/kg/56W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
11,892,1951
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 240 mg/kg/1W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.11947Volume(issue)/page/year:
9,177,1955
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 4 ug/plate
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 5,747,1984
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 2400 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
192,239,1987
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 10 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
89,95,1981
TYPE OF TEST
: Phage inhibition capacity
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 50 mg/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
41,532,1981
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 200 ug/L
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United
States
of America. (National Academy of Sciences, Printing & Pub. Office, 2101
Constitution Ave., Washington, DC 20418) V.11915Volume(issue)/page/year: 74,1378,1977
TYPE OF TEST
: Specific locus test
ROUTE OF EXPOSURE
: Parenteral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 5 mmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
33,2354,1973
TYPE OF TEST
: Specific locus test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 5 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
234,71,1990
TYPE OF TEST
: DNA repair
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 36 gm/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
290,175,1993
TYPE OF TEST
: Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE
: Parenteral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 5 mmol/L
REFERENCE :
EJGCA9 Egyptian Journal of Genetics and Cytology. (Egyptian Soc. of
Genetics, c/o Alexandria Univ., Faculty of Agriculture, Dept. of
Genetics,
Alexandria, Egypt) V.11972- Volume(issue)/page/year: 4,400,1975
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Multiple routes
TEST SYSTEM
: Non-mammalian species
DOSE/DURATION
: 188 ppb
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
292,83,1993
TYPE OF TEST
TEST SYSTEM
: DNA adduct
: Fish - salmon Testis
DOSE/DURATION
: 5 ug/1H (Continuous)
REFERENCE :
BIJOAK Biochemical Journal. (Biochemical Soc. Book Depot, POB 32,
Commerce
Way, Colchester, Essex CO2 8HP, UK) V.11906Volume(issue)/page/year:
110,159,1968
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Fish - not otherwise specified Liver
DOSE/DURATION
: 200 nmol/L
REFERENCE :
HKXUDL Huanjing Kexue Xuebao. Environmental Sciences Journal. (China
International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China)
V.11981- Volume(issue)/page/year: 4,368,1984
TYPE OF TEST
TEST SYSTEM
otherwise
: Unscheduled DNA synthesis
: Fish - not otherwise specified Cells - not
specified
DOSE/DURATION
: 100 umol/L
REFERENCE :
CBPCEE Comparative Biochemistry and Physiology, C: Pharmacology,
Toxicology
and Endocrinology. (Elsevier Science, 660 White Plains Rd., Tarrytown, NY
10591) V.741983- Volume(issue)/page/year: 86,399,1987
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 30 umol/L
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United
States
of America. (National Academy of Sciences, Printing & Pub. Office, 2101
Constitution Ave., Washington, DC 20418) V.11915Volume(issue)/page/year: 85,3513,1988
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 3 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
419,91,1998
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Human Fibroblast
DOSE/DURATION
: 100 umol/L
REFERENCE :
CBPCEE Comparative Biochemistry and Physiology, C: Pharmacology,
Toxicology
and Endocrinology. (Elsevier Science, 660 White Plains Rd., Tarrytown, NY
10591) V.741983- Volume(issue)/page/year: 86,399,1987
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
: Unscheduled DNA synthesis
: Human HeLa cell
: 100 umol/L
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
38,2621,1978
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human Cells - not otherwise specified
DOSE/DURATION
: 10 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
42,3676,1982
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 9 umol/L
REFERENCE :
DTESD7 Developments in Toxicology and Environtal Science. (Elsevier
Science, New York, NY) V.1-15, 1977-87. Discontinued
Volume(issue)/page/year: 10,277,1982
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Intratracheal
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 75 mg/kg/16H (Intermittent)
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
326,147,1995
TYPE OF TEST
: Morphological transformation
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 180 mg/kg
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
40,1157,1980
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - rat Embryo
DOSE/DURATION
: 3 mg/L
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 67,1303,1981
TYPE OF TEST
: DNA adduct
ROUTE OF EXPOSURE
: Intratracheal
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 75 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
312,165,1994
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
: DNA adduct
: Rodent - rat Liver
: 3 umol/L
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
419,91,1998
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 100 umol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 3,11,1981
TYPE OF TEST
: Sister chromatid exchange
ROUTE OF EXPOSURE
: Intratracheal
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 150 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
312,165,1994
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 10 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
91,467,1981
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 500 mg/kg
REFERENCE :
TJIDAH Tokyo Jikeikai Ika Daigaku Zasshi. Tokyo Jikeikai Medical
Journal.
(3-25-8, Nishi Shinbashi, Minato-ku, Tokyo 105, Japan) V.661951Volume(issue)/page/year: 101,259,1986
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 2 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
12(Suppl 13),103,1988
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - mouse Fibroblast
DOSE/DURATION
: 4 mg/L
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 67,1303,1981
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
: Morphological transformation
: Rodent - mouse Embryo
: 12500 ug/L
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 4,105,1982
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Rodent - mouse Liver
DOSE/DURATION
: 60 umol/L
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 62,947,1979
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Rodent - mouse Cells - not otherwise specified
DOSE/DURATION
: 1 mg/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11969- Volume(issue)/page/year:
4,389,1971/1972
TYPE OF TEST
: DNA adduct
ROUTE OF EXPOSURE
: Administration onto the skin
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 192 umol/kg
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 5,231,1984
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - mouse Cells - not otherwise specified
DOSE/DURATION
: 10 umol/L
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 65,1321,1980
TYPE OF TEST
: Host-mediated assay
TEST SYSTEM
: Rodent - mouse Bacteria - Salmonella typhimurium
DOSE/DURATION
: 1600 mg/kg
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 62,911,1979
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - hamster
DOSE/DURATION
: 1800 mg/kg/24H
REFERENCE :
AMSHAR Acta Morphologica Academiae Scientiarum Hungaricae. (Budapest,
Hungary) V.1-30, 1951-82. Volume(issue)/page/year: 27,199,1979
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 109 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
46,27,1977
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 6 mg/L/7D (Continuous)
REFERENCE :
IJCNAW International Journal of Cancer. (International Union Against
Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.11966Volume(issue)/page/year: 9,435,1972
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - hamster Kidney
DOSE/DURATION
: 80 ug/L
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.11947Volume(issue)/page/year:
37,873,1978
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 100 ug/L
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 17,149,1980
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - hamster Fibroblast
DOSE/DURATION
: 5 mg/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11958Volume(issue)/page/year:
20,1297,1971
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - hamster Kidney
DOSE/DURATION
: 5 mg/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11958Volume(issue)/page/year:
20,1297,1971
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 1 mg/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11969- Volume(issue)/page/year:
4,389,1971/1972
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 1 mg/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland)
4,389,1971/1972
V.1-
1969-
Volume(issue)/page/year:
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - hamster Cells - not otherwise specified
DOSE/DURATION
: 450 umol/L
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11975- Volume(issue)/page/year:
53,163,1990
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - hamster
DOSE/DURATION
: 1800 mg/kg/24H
REFERENCE :
AMSHAR Acta Morphologica Academiae Scientiarum Hungaricae. (Budapest,
Hungary) V.1-30, 1951-82. Volume(issue)/page/year: 27,199,1979
TYPE OF TEST
: Sister chromatid exchange
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - hamster
DOSE/DURATION
: 900 mg/Kg/24H
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
66,65,1979
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 100 umol/L
REFERENCE :
CMMUAO Chemical Mutagens. Principles and Methods for Their Detection.
(Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.11971Volume(issue)/page/year: 6,1,1980
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 5 mg/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 7,137,1985
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 1 mg/L/3H
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.11947Volume(issue)/page/year:
39,540,1979
TYPE OF TEST
ROUTE OF EXPOSURE
TEST SYSTEM
DOSE/DURATION
REFERENCE :
:
:
:
:
Sperm Morphology
Oral
Rodent - hamster
900 mg/kg/24H
AMSHAR Acta Morphologica Academiae Scientiarum Hungaricae. (Budapest,
Hungary) V.1-30, 1951-82. Volume(issue)/page/year: 27,199,1979
*** REVIEWS ***
ACGIH TLV-Suspected human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 3,45,1973
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 32,135,1983
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 32,135,1983
IARC Cancer Review:Group 2A
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,56,1987
TOXICOLOGY REVIEW
AEHLAU Archives of Environmental Health.
(Heldref Pub., 4000 Albemarle
St.,
NW, Washington, DC 20016)
23,6,1971
V.1-
1960-
Volume(issue)/page/year:
TOXICOLOGY REVIEW
ACRSAJ Advances in Cancer Research. (Academic Press, Inc., 465 S.
Lincoln
Dr., Troy, MO 63379) V.11953- Volume(issue)/page/year: 7,475,1963
TOXICOLOGY REVIEW
85DHAX "Medical and Biologic Effects of Environmental Pollutants Series,"
Washington, DC, National Academy of Sciences, 1972-77
Volume(issue)/page/year: Pc,4,1972
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - B0045
No.
No.
No.
No.
of
of
of
of
Facilities: 149 (estimated)
Industries: 4
Occupations: 4
Employees: 2311 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; SHE-clonal
assay
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-mouse prostate
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo;
Host-mediated assay
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: V79 cell culture-gene mutation
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-BALB/c-3T3; In vitro
UDS
in rat liver
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9; In vivo
SCE-nonhuman
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Inconclusive: In vitro UDS-human fibroblast
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Polynuclear aromatic hydrocarbons by HPLC,
5506; by GC, 5515
NTP 8th Annual Report on Carcinogens, 1998:Reasonably Anticipated to be
Human Carcinogen
BENZENE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
:
:
:
:
:
:
:
:
CY1400000
Benzene
71-43-2
199907
231
C6-H6
78.12
RH
COMPOUND DESCRIPTOR
: Agricultural Chemical
Tumorigen
Drug
Mutagen
Reproductive Effector
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* (6)Annulene
* Benzeen
* Benzen
* Benzene
* Benzin (Obs.)
* Benzine (Obs.)
* Benzol
* Benzole
* Benzolene
* Benzolo
* Bicarburet of hydrogen
* Carbon oil
* Coal naphtha
* Cyclohexatriene
* Fenzen
* Mineral naphtha
* NCI-C55276
* Phene
* Phenyl hydride
* Pyrobenzol
* Pyrobenzole
* RCRA waste number U019
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Open irritation test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 15 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
23,95,1962
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 20 mg/24H
REACTION SEVERITY
: Moderate
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,25,1986
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
Standard Draize test
Administration into the eye
Rodent - rabbit
88 mg
REACTION SEVERITY
: Moderate
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21,
1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year:
14,387,1956
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2 mg/24H
REACTION SEVERITY
: Severe
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,25,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 2 pph/5M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TABIA2 Tabulae Biologicae. (The Hague, Netherlands) V.1-22, 1925-63.
Discontinued. Volume(issue)/page/year: 3,231,1933
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka
Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.11959Volume(issue)/page/year: 22,883,1980
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 150 ppm/1Y-I
TOXIC EFFECTS :
Blood - other changes
Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
BLUTA9 Blut. (Springer-Verlag New York, Inc., Service Center, 44 Hartz
Way,
Secaucus, NJ 07094) V.11955- Volume(issue)/page/year: 28,293,1974
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 100 ppm
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Gastrointestinal - nausea or vomiting
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
INMEAF Industrial Medicine. (Chicago, IL) V.1-18, 1932-49. For
publisher
information, see IOHSA5. Volume(issue)/page/year: 17,199,1948
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 65 mg/m3/5Y
TOXIC EFFECTS :
Blood - other changes
REFERENCE :
ARGEAR Archiv fuer Geschwulstforschung. (VEB Verlag Volk und Gesundheit
Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.11949Volume(issue)/page/year: 44,145,1974
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 194 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena,
J.M.,
Springfield, IL, C.C. Thomas, 1970 Volume(issue)/page/year: 2,73,1970
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 930 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
7,767,1965
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 10000 ppm/7H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
28ZRAQ "Toxicology and Biochemistry of Aromatic Hydrocarbons," Gerarde,
H.,
New York, Elsevier, 1960 Volume(issue)/page/year: -,113,1960
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1100 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APYPAY Acta Physiologica Polonica. (Karger-Libri, POB CH-4009, Warszawa,
Switzerland) V.1-41, 1950-90.
Volume(issue)/page/year: 12,173,1961
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 4700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA.
(Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year:
32(3),349,1967
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 9980 ppm
TOXIC EFFECTS :
Behavioral - general anesthetic
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 25,366,1943
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 48 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974.
(National
Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair
Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
Volume(issue)/page/year: 1,5,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 340 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of
Sciences, 2 E. 63rd St., New York, NY 10021) V.11877Volume(issue)/page/year: 243,104,1975
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.)
Volume(issue)/page/year: 4,1313,1935
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 146000 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders
Co.,
1956-59 Volume(issue)/page/year: 1,324,1955
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 170000 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders
Co.,
1956-59 Volume(issue)/page/year: 1,324,1955
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 45000 ppm/30M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 26,69,1944
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >9400 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
7,559,1965
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 88 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without
sensory
change
Sense Organs and Special Senses (Eye) - hemorrhage
Gastrointestinal - gastritis
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76-
Volume(issue)/page/year: (Suppl 2),45,1977
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: >9400 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
7,559,1965
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 527 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders
Co.,
1956-59 Volume(issue)/page/year: 1,42,1955
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Amphibian - frog
DOSE/DURATION
: 1400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1313,1935
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 5700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 39(4),86,1974
(V/O
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 20000 ppm/5M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 138,65,1928
TYPE OF TEST
ROUTE OF EXPOSURE
: LDLo - Lowest published lethal dose
: Intraperitoneal
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 1500 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Behavioral - convulsions or effect on seizure threshold
Behavioral - irritability
REFERENCE :
AJHYA2 American Journal of Hygiene. (Baltimore, MD) V.1-80, 1921-64.
For
publisher information, see AJEPAS. Volume(issue)/page/year: 7,276,1927
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 6600 mg/kg/27W-I
TOXIC EFFECTS :
Blood - leukopenia
Blood - changes in erythrocyte (RBC) count
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21,
1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year:
14,387,1956
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 23 mg/m3/4H/8D-I
TOXIC EFFECTS :
Liver - changes in liver weight
Endocrine - changes in pituitary weight
REFERENCE :
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.
Toxicology of New Industrial Chemical Substances. For English
translation,
see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.11961Volume(issue)/page/year: 12,5,1971
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 300 ppm/6H/13W-I
TOXIC EFFECTS :
Blood - leukopenia
REFERENCE :
AJIMD8 American Journal of Industrial Medicine. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.11980- Volume(issue)/page/year:
7,457,1985
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
Blood - leukopenia
:
:
:
:
TCLo - Lowest published toxic concentration
Inhalation
Rodent - rat
300 ppm/6H/99W-I
Blood - changes in bone marrow (not otherwise specified)
Related to Chronic Data - death
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 4,605,1978
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 17 gm/kg/17W-I
TOXIC EFFECTS :
Blood - changes in spleen
Blood - changes in leukocyte (WBC) count
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-289,1986
(Research
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1000 ppm/7H/28W-I
TOXIC EFFECTS :
Blood - changes in other cell count (unspecified)
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 26,37,1944
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 500 ppm/6H/3W-I
TOXIC EFFECTS :
Blood - pigmented or nucleated red blood cells
Blood - changes in bone marrow (not otherwise specified)
Blood - changes in leukocyte (WBC) count
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 5,1025,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 18 mg/kg/21D-I
TOXIC EFFECTS :
Blood - changes in erythrocyte (RBC) count
Blood - changes in leukocyte (WBC) count
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
AJHYA2 American Journal of Hygiene. (Baltimore, MD) V.1-80, 1921-64.
For
publisher information, see AJEPAS. Volume(issue)/page/year: 7,276,1927
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: TDLo - Lowest published toxic dose
: Subcutaneous
: Rodent - rat
DOSE/DURATION
: 2197 mg/kg/5D-I
TOXIC EFFECTS :
Blood - pigmented or nucleated red blood cells
Blood - changes in leukocyte (WBC) count
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
INHEAO Industrial Health. (National Institute of Industrial Health,
6-21-1
Nagao, Tama-ku, Kawasaki, 213 Japan) V.11963Volume(issue)/page/year:
3,91,1965
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 13536 mg/kg/12W-I
TOXIC EFFECTS :
Liver - other changes
Kidney, Ureter, Bladder - other changes in urine composition
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other hydrolases
REFERENCE :
BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001,
00-068
Warsaw 1, Poland) V.41971- Volume(issue)/page/year: 17,101,1984
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5 mL/kg/10D-I
TOXIC EFFECTS :
Liver - other changes
Nutritional and Gross Metabolic - changes in iron
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications &
Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1Volume(issue)/page/year: 36,283,1998
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 4250 mg/kg/17W-I
TOXIC EFFECTS :
Blood - other changes
Blood - changes in leukocyte (WBC) count
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-289,1986
1963-
(Research
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 300 ppm/6H/13W-I
TOXIC EFFECTS :
Blood - normocytic anemia
Blood - thrombocytopenia
Related to Chronic Data - changes in testicular weight
REFERENCE :
AJIMD8 American Journal of Industrial Medicine. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.11980- Volume(issue)/page/year:
7,457,1985
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 25 ppm/6H/5D-I
TOXIC EFFECTS :
Endocrine - changes in spleen weight
Blood - changes in leukocyte (WBC) count
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
56,159,1991
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 10 ppm/6H/10W-I
TOXIC EFFECTS :
Endocrine - changes in spleen weight
Blood - changes in spleen
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
58,492,1981
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 10 ppm/6H/26W-I
TOXIC EFFECTS :
Blood - changes in spleen
Blood - changes in other cell count (unspecified)
Blood - changes in erythrocyte (RBC) count
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
20,337,1984
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 211 ppm/6H/7D-I
TOXIC EFFECTS :
Blood - leukopenia
Endocrine - changes in spleen weight
Blood - changes in leukocyte (WBC) count
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
85,92,1986
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: TCLo - Lowest published toxic concentration
: Inhalation
: Rodent - mouse
DOSE/DURATION
: 300 ppm/6H/16W-I
TOXIC EFFECTS :
Blood - changes in bone marrow (not otherwise specified)
Blood - changes in other cell count (unspecified)
Related to Chronic Data - death
REFERENCE :
AJIMD8 American Journal of Industrial Medicine. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.11980- Volume(issue)/page/year:
7,447,1985
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 48 ppm/6H/14D-I
TOXIC EFFECTS :
Blood - leukopenia
Endocrine - changes in spleen weight
Immunological Including Allergic - decrease in humoral immune response
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
85,92,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2197 mg/kg/5D-I
TOXIC EFFECTS :
Endocrine - changes in spleen weight
Endocrine - changes in thymus weight
Blood - changes in leukocyte (WBC) count
REFERENCE :
INHEAO Industrial Health. (National Institute of Industrial Health,
6-21-1
Nagao, Tama-ku, Kawasaki, 213 Japan) V.11963Volume(issue)/page/year:
3,91,1965
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 100 ppm/6H/72W-I
TOXIC EFFECTS :
Blood - normocytic anemia
Blood - leukopenia
Related to Chronic Data - death
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
54,323,1980
TYPE OF TEST
:
ROUTE OF EXPOSURE
:
SPECIES OBSERVED
:
DOSE/DURATION
:
TOXIC EFFECTS :
Blood - hemorrhage
Blood - other changes
TCLo - Lowest published toxic concentration
Inhalation
Rodent - rabbit
500 mg/m3/3H/13W-I
Lungs, Thorax, or Respiration - other changes
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 24(1),80,1959
(V/O
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - pig
DOSE/DURATION
: 100 ppm/6H/3W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition
Blood - pigmented or nucleated red blood cells
Blood - changes in bone marrow (not otherwise specified)
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 5,1025,1979
** TUMORIGENIC DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 200 mg/m3/78W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Blood - leukemia
Blood - thrombocytopenia
REFERENCE :
EJCAAH European Journal of Cancer. (Oxford, UK) V.1-17(6), 1965-1981.
For
publisher information, see EJCODS. Volume(issue)/page/year: 7,83,1971
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 10 ppm/8H/10Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Blood - leukemia
REFERENCE :
TRBMAV Texas Reports on Biology and Medicine. (Galveston, TX)
V.1-41(2),
1943-81/82. Discontinued. Volume(issue)/page/year: 37,153,1978
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 52 gm/kg/52W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Endocrine - tumors
Blood - leukemia
REFERENCE :
MELAAD Medicina del Lavoro. Industrial Medicine. (Via S. Barnaba, 8,
20122
Milan, Italy) V.161925- Volume(issue)/page/year: 70,352,1979
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1200 ppm/6H/10W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Sense Organs and Special Senses (Ear) - effect, not otherwise specified
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research.
(Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.11954Volume(issue)/page/year: 25,75,1984
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 18250 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Endocrine - tumors
Blood - lymphoma, including Hodgkin's disease
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-289,1986
(Research
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 300 ppm/6H/16W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Blood - lymphoma, including Hodgkin's disease
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
75,358,1984
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1200 gm/kg/49W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.11947Volume(issue)/page/year:
16,275,1962
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1200 mg/kg/8W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
82,19,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 600 mg/kg/17W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Blood - leukemia
Blood - lymphoma, including Hodgkin's disease
REFERENCE :
KRANAW Krankheitsforschung. (Leipzig, Ger. Dem. Rep.) V.1-9, 1925-32.
Discontinued. Volume(issue)/page/year: 9,403,1932
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 670 mg/kg/19W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Blood - leukemia
Blood - lymphoma, including Hodgkin's disease
REFERENCE :
KLWOAZ Klinische Wochenscrift. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.11922- Volume(issue)/page/year:
12,109,1933
TYPE OF TEST
: TC - Toxic concentration (other than lowest)
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 150 ppm/15M/8Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Blood - leukemia
REFERENCE :
BLOOAW Blood. (Grune & Stratton, Inc., 465 S. Lincoln Dr., Troy, MO
63379)
V.11946- Volume(issue)/page/year: 52,285,1978
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 52 gm/kg/1Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Sense Organs and Special Senses (Ear) - effect, not otherwise specified
Blood - leukemia
REFERENCE :
AJIMD8 American Journal of Industrial Medicine. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.11980- Volume(issue)/page/year:
4,589,1983
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: TD - Toxic dose (other than lowest)
: Oral
: Rodent - rat
DOSE/DURATION
: 10 gm/kg/52W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Endocrine - tumors
Blood - leukemia
REFERENCE :
MELAAD Medicina del Lavoro. Industrial Medicine. (Via S. Barnaba, 8,
20122
Milan, Italy) V.161925- Volume(issue)/page/year: 70,352,1979
TYPE OF TEST
: TC - Toxic concentration (other than lowest)
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 600 mg/m3/4Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Blood - leukemia
REFERENCE :
NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10
Shattuck St., Boston, MA 02115) V.1981928Volume(issue)/page/year:
271,872,1964
TYPE OF TEST
: TC - Toxic concentration (other than lowest)
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 150 ppm/11Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Blood - lymphoma, including Hodgkin's disease
REFERENCE :
BLUTA9 Blut. (Springer-Verlag New York, Inc., Service Center, 44 Hartz
Way,
Secaucus, NJ 07094) V.11955- Volume(issue)/page/year: 28,293,1974
TYPE OF TEST
: TC - Toxic concentration (other than lowest)
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1200 ppm/6H/10W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Sense Organs and Special Senses (Ear) - effect, not otherwise specified
Lungs, Thorax, or Respiration - tumors
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research.
(Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.11954Volume(issue)/page/year: 25,75,1984
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2400 mg/kg/8W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
82,19,1986
TYPE OF TEST
: TC - Toxic concentration (other than lowest)
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 8 ppb/4W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Blood - leukemia
REFERENCE :
NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10
Shattuck St., Boston, MA 02115) V.1981928Volume(issue)/page/year:
316,1044,1987
TYPE OF TEST
: TC - Toxic concentration (other than lowest)
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 10 mg/m3/11Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Blood - leukemia
REFERENCE :
BJIMAG British Journal of Industrial Medicine. (British Medical Journal,
Box 560B, Kennebunkport, ME 04046) V.11944Volume(issue)/page/year:
44,124,1987
TYPE OF TEST
: TC - Toxic concentration (other than lowest)
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 300 ppm/6H/16W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Blood - leukemia
REFERENCE :
IHRMEQ Immunology and Hematology Research, Monograph. (Immunology
Research
Foundation, Inc., 5022 W. Timberwood, Newburg, IN 47630)
No.11983Volume(issue)/page/year: (3),156,1984
** REPRODUCTIVE DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TCLo - Lowest published toxic concentration
Inhalation
Rodent - rat
670 mg/m3/24H
female 15 day(s) pre-mating
female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females
pregnant
per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA.
(Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year:
33(1-3),327,1968
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 56600 ug/m3/24H
SEX/DURATION
: female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA.
(Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year:
33(7-9),112,1968
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 50 ppm/24H
SEX/DURATION
: female 7-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
(e.g., placenta, umbilical cord)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
JHEMA2 Journal of Hygiene, Epidemiology, Microbiology, and Immunology.
(Avicenum, Malostranske namesti 28, 11802 Prague 1, Czechoslovakia) V.11957- Volume(issue)/page/year: 24,363,1980
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 150 ppm/24H
SEX/DURATION
: female 7-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
JHEMA2 Journal of Hygiene, Epidemiology, Microbiology, and Immunology.
(Avicenum, Malostranske namesti 28, 11802 Prague 1, Czechoslovakia) V.11957- Volume(issue)/page/year: 24,363,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 9 gm/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 19,41A,1979
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: TDLo - Lowest published toxic dose
: Oral
: Rodent - mouse
DOSE
: 12 gm/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 19,41A,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 6500 mg/kg
SEX/DURATION
: female 8-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss,
Inc.,
41 E. 11th St., New York, NY 10003) V.11980Volume(issue)/page/year:
6,361,1986
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 500 ppm/7H
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
40,993,1979
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 500 mg/m3/12H
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York,
Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.11978Volume(issue)/page/year: 8,425,1985
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 5 ppm
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - cytological changes
(including
somatic cell genetic material)
Reproductive - Specific Developmental Abnormalities - blood and lymphatic
systems (including spleen and marrow)
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 42,171,1986
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 20 ppm/6H
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - blood and lymphatic
systems (including spleen and marrow)
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 10,224,1988
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 5 mg/kg
SEX/DURATION
: male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora
lutea)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.
Toxicology of New Industrial Chemical Substances. For English
translation,
see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.11961Volume(issue)/page/year: 15,30,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 219 mg/kg
SEX/DURATION
: female 14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - blood and lymphatic
systems (including spleen and marrow)
Reproductive - Specific Developmental Abnormalities - hepatobiliary
system
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
18,1,1991
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 1100 mg/kg
SEX/DURATION
: female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - other effects to embryo
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.11981- Volume(issue)/page/year: 1,125,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 7030 mg/kg
SEX/DURATION
: female 12-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
(e.g., placenta, umbilical cord)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o
Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho,
Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher
information, see CGANE7. Volume(issue)/page/year: 15,47,1975
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 13200 ug/kg
SEX/DURATION
: female 13-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - cytological changes
(including
somatic cell genetic material)
REFERENCE :
ICHUDW Yichuan. Heredity. (China International Book Trading Corp., POB
2820, Beijing, Peop. Rep. China) V.11979- Volume(issue)/page/year:
4(6),24,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 4 gm/kg
SEX/DURATION
: female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
alive at weaning per # alive at day 4)
REFERENCE :
NEZAAQ Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. (Nippon
Eisei
Gakkai, c/o Kyoto Daigaku Igakubu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto
606,
Japan) V.11946- Volume(issue)/page/year: 25,438,1970
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 1 gm/m3/24H
SEX/DURATION
: female 7-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Fertility - abortion
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York,
Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.11978Volume(issue)/page/year: 8,425,1985
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 1 gm/m3/24H
SEX/DURATION
: female 7-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York,
Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.11978Volume(issue)/page/year: 8,425,1985
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 10 ppm
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 82,81,1989
TYPE OF TEST
: Specific locus test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 11250 umol/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
5,325,1985
TYPE OF TEST
ROUTE OF EXPOSURE
TEST SYSTEM
DOSE/DURATION
REFERENCE :
CONAEL Contaminacion
:
:
:
:
Sex chromosome loss and nondisjunction
Oral
Insect - Drosophila melanogaster
7500 ppm
Ambiental. (Centro de Ciencias de la Atmosfera,
Universidad Nacional Autonoma de Mexico, 04510 Mexico City, Mexico) V.11985- Volume(issue)/page/year: 1,35,1985
TYPE OF TEST
: Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE
: Multiple routes
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 27000 ppm
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
25,211,1995
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 549 mg/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
5,271,1985
TYPE OF TEST
: Gene conversion and mitotic recombination
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 275 mg/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
5,271,1985
TYPE OF TEST
: Sex chromosome loss and nondisjunction
TEST SYSTEM
: Mold - Aspergillus nidulans
DOSE/DURATION
: 35000 ppm
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
147,288,1985
TYPE OF TEST
: Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE
: Inhalation
TEST SYSTEM
: Insect - grasshopper
DOSE/DURATION
: 14 pph/16H
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
113,467,1983
TYPE OF TEST
: Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Non-mammalian species
DOSE/DURATION
: 75 gm/kg
REFERENCE :
ACHAAH Acta Haematologica. (S. Karger Pub., Inc., 79 Fifth Ave., New
York,
NY 10003) V.11948- Volume(issue)/page/year: 26,281,1961
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human Leukocyte
DOSE/DURATION
: 2200 umol/L
REFERENCE :
INHEAO Industrial Health. (National Institute of Industrial Health,
6-21-1
Nagao, Tama-ku, Kawasaki, 213 Japan) V.11963Volume(issue)/page/year:
12,23,1974
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human HeLa cell
DOSE/DURATION
: 2200 umol/L
REFERENCE :
INHEAO Industrial Health. (National Institute of Industrial Health,
6-21-1
Nagao, Tama-ku, Kawasaki, 213 Japan) V.11963Volume(issue)/page/year:
12,23,1974
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 5 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
45,2471,1985
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Inhalation
TEST SYSTEM
: Human
DOSE/DURATION
: 125 ppm/1Y
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle
St.,
NW, Washington, DC 20016) V.11960- Volume(issue)/page/year:
22,373,1971
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human Leukocyte
DOSE/DURATION
: 1 mmol/L/72H
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
47,75,1978
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 1 mg/L
REFERENCE :
BZARAZ Biologicheskii Zhurnal Armenii. Biological Journal of Armenia.
(V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.191966Volume(issue)/page/year: 26(12),38,1973
TYPE OF TEST
ROUTE OF EXPOSURE
TEST SYSTEM
DOSE/DURATION
:
:
:
:
Cytogenetic analysis
Unreported
Human
10 ppm/4W
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11967- Volume(issue)/page/year: 19,33,1979
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 200 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
43,1330,1983
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 1 gm/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
5,497,1985
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Inhalation
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 1 ppm/6H
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 8,29,1986
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 1 mmol/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
5,371,1985
TYPE OF TEST
: DNA inhibition
ROUTE OF EXPOSURE
: Inhalation
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 400 ppm
REFERENCE :
BLUTA9 Blut. (Springer-Verlag New York, Inc., Service Center, 44 Hartz
Way,
Secaucus, NJ 07094) V.11955- Volume(issue)/page/year: 21,250,1970
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 1 mmol/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11969- Volume(issue)/page/year:
42,353,1982
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Rodent - rat Bone marrow
DOSE/DURATION
: 1 mmol/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11969- Volume(issue)/page/year:
42,353,1982
TYPE OF TEST
: Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE
: Subcutaneous
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 1 gm/L
REFERENCE :
NJMSAG Nagoya Journal of Medical Science. (Nagoya Univ. School of
Medicine,
65 Tsuruma-cho, Showa- ku, Nagoya 466, Japan) V.21927Volume(issue)/page/year: 28,204,1966
TYPE OF TEST
: Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE
: Subcutaneous
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 2200 mg/kg
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11969- Volume(issue)/page/year:
42,353,1982
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Inhalation
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 300 mg/m3/16W (Intermittent)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 42(1),32,1977
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Subcutaneous
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 2400 mg/kg/12D (Intermittent)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 37(10),36,1972
(V/O
(V/O
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 234 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
242,111,1990
TYPE OF TEST
ROUTE OF EXPOSURE
TEST SYSTEM
DOSE/DURATION
:
:
:
:
Cytogenetic analysis
Oral
Rodent - rat
39060 ug/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
298,81,1992
TYPE OF TEST
: Sister chromatid exchange
ROUTE OF EXPOSURE
: Inhalation
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 3 ppm/6H
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 8,29,1986
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - rat Leukocyte
DOSE/DURATION
: 1 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
300,241,1993
TYPE OF TEST
: Micronucleus test
TEST SYSTEM
: Rodent - mouse Embryo
DOSE/DURATION
: 12500 nmol/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
19(Suppl 20),21,1992
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Subcutaneous
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 440 mg/kg
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11969- Volume(issue)/page/year:
39,129,1982
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 40 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
147,294,1985
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 264 mg/kg/24H
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year:
2,111,1987
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Inhalation
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 10 ppm/6H
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 8,29,1986
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 62500 ug/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
5,587,1985
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Rodent - mouse Embryo
DOSE/DURATION
: 2500 mg/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
5,639,1985
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - mouse Embryo
DOSE/DURATION
: 1 gm/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
5,659,1985
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - mouse Fibroblast
DOSE/DURATION
: 150 gm/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 3,1235,1982
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 3840 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
203,155,1988
TYPE OF TEST
: DNA adduct
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 2640 mg/kg/3D (Continuous)
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK)
Volume(issue)/page/year: 17,151,1996
V.1-
1980-
TYPE OF TEST
: Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 2 gm/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
343,157,1995
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Rodent - mouse Cells - not otherwise specified
DOSE/DURATION
: 5 mmol/L
REFERENCE :
CBTOE2 Cell Biology and Toxicology. (Princeton Scientific Pub., Inc.,
301
N. Harrison St., CN 5279, Princeton, NJ 08540) V.11984Volume(issue)/page/year: 2,231,1986
TYPE OF TEST
: DNA inhibition
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 20 gm/kg
REFERENCE :
ARGEAR Archiv fuer Geschwulstforschung. (VEB Verlag Volk und Gesundheit
Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.11949Volume(issue)/page/year: 51,605,1981
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 10 mmol/L
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
29,161,1985
TYPE OF TEST
: DNA inhibition
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 880 mg/kg
REFERENCE :
RCOCB8 Research Communications in Chemical Pathology and Pharmacology.
(PJD
Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.11970Volume(issue)/page/year: 60,27,1988
TYPE OF TEST
: DNA inhibition
ROUTE OF EXPOSURE
: Inhalation
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 3000 ppm/4H (Continuous)
REFERENCE :
RCOCB8 Research Communications in Chemical Pathology and Pharmacology.
(PJD
Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.11970Volume(issue)/page/year: 60,27,1988
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - mouse Bone marrow
DOSE/DURATION
: 3 mmol/L
REFERENCE :
RCOCB8 Research Communications in Chemical Pathology and Pharmacology.
(PJD
Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.11970Volume(issue)/page/year: 60,27,1988
TYPE OF TEST
: Sister chromatid exchange
ROUTE OF EXPOSURE
: Inhalation
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 10 ppm/6H
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 8,29,1986
TYPE OF TEST
: Sister chromatid exchange
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 5 gm/kg
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 5,450,1983
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 20 mg/kg
REFERENCE :
BEXBAN Bulletin of Experimental Biology and Medicine (English
Translation).
Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY
10013) V.411956- Volume(issue)/page/year: 96,1741,1984
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 264 mg/kg/3D (Continuous)
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 2,43,1980
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Inhalation
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 3000 ppm
REFERENCE :
EVSRBT Environmental Science Research. (Plenum Pub. Corp., 233 Spring
St.,
New York, NY 10013) V.11972- Volume(issue)/page/year: 25,257,1982
TYPE OF TEST
: Dominant lethal test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 1 mg/kg
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
39,173,1978
TYPE OF TEST
: Dominant lethal test
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 5 mg/kg
REFERENCE :
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.
Toxicology of New Industrial Chemical Substances. For English
translation,
see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.11961Volume(issue)/page/year: 15,30,1979
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 12500 ug/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
5,525,1985
TYPE OF TEST
: Mutation in mammalian somatic cells
ROUTE OF EXPOSURE
: Inhalation
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 40 ppb/6W (Continuous)
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
268,49,1992
TYPE OF TEST
: Mutation in mammalian somatic cells
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 2 gm/kg/5D (Continuous)
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
28,342,1996
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 100 ug/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 4,291,1983
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 17 mmol/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
5,367,1985
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 550 mg/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
5,427,1985
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 600 mg/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
5,443,1985
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 750 mg/L
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.11895- Volume(issue)/page/year:
236,933,1987
TYPE OF TEST
: Sex chromosome loss and nondisjunction
TEST SYSTEM
: Rodent - hamster Liver
DOSE/DURATION
: 62500 ug/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
5,397,1985
TYPE OF TEST
: Sex chromosome loss and nondisjunction
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 30 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
373,113,1997
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 10 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
373,113,1997
TYPE OF TEST
ROUTE OF EXPOSURE
TEST SYSTEM
DOSE/DURATION
:
:
:
:
DNA damage
Subcutaneous
Rodent - rabbit
2344 mg/kg
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
63,209,1989
TYPE OF TEST
: DNA inhibition
ROUTE OF EXPOSURE
: Subcutaneous
TEST SYSTEM
: Rodent - rabbit
DOSE/DURATION
: 2 gm/kg
REFERENCE :
ACHAAH Acta Haematologica. (S. Karger Pub., Inc., 79 Fifth Ave., New
York,
NY 10003) V.11948- Volume(issue)/page/year: 38,104,1967
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Rodent - rabbit Bone marrow
DOSE/DURATION
: 1 mmol/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11969- Volume(issue)/page/year:
42,353,1982
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Mammal - cat Bone marrow
DOSE/DURATION
: 1 mmol/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11969- Volume(issue)/page/year:
42,353,1982
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Subcutaneous
TEST SYSTEM
: Rodent - rabbit
DOSE/DURATION
: 8400 mg/kg
REFERENCE :
PSDTAP Proceedings of the European Society for the Study of Drug
Toxicity.
(Princeton, NJ 08540) V.1-15, 1963-74. For publisher information, see
PESTD5. Volume(issue)/page/year: 15,275,1974
*** REVIEWS ***
ACGIH TLV-Confirmed human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 1.6 mg/m3 (10 ppm); CL 8 mg/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Human Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 7,203,1974
IARC Cancer Review:Animal Sufficient Evidence
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,120,1987
IARC Cancer Review:Animal Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 29,93,1982
IARC Cancer Review:Human Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 29,93,1982
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 7,203,1974
IARC Cancer Review:Group 1
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,120,1987
TOXICOLOGY REVIEW
ARPAAQ Archives of Pathology. (Chicago, IL) V.5(3)-50(3), 1928-50;
V.70-99, 1960-75. For publisher information, see APLMAS.
Volume(issue)/page/year: 11,434,1931
TOXICOLOGY REVIEW
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 11,163,1975
TOXICOLOGY REVIEW
AEHLAU Archives of Environmental Health.
(Heldref Pub., 4000 Albemarle
St.,
NW, Washington, DC 20016)
22,373,1971
V.1-
1960-
Volume(issue)/page/year:
TOXICOLOGY REVIEW
PAREAQ Pharmacological Reviews. (Williams & Wilkins, 428 E. Preston St.,
Baltimore, MD 21202) V.11949- Volume(issue)/page/year: 4,1,1952
TOXICOLOGY REVIEW
FNSCA6 Forensic Science.
(Lausanne, Switzerland)
V.1-11, 1972-78. For
pub
lisher information, see FSINDR.
Volume(issue)/page/year: 2,67,1973
TOXICOLOGY REVIEW
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
47,75,1978
TOXICOLOGY REVIEW
AMSVAZ Acta Medica Scandinavica. (Almqvist & Wiksell, POB 45150, S-10430
Stockholm, Sweden) V.52-224, 1919-88. Volume(issue)/page/year:
118,354,1944
TOXICOLOGY REVIEW
ZHPMAT Zentralblatt fuer Bakteriologie, Parasitenkunde,
Infektionskrankheiten und Hygiene, Abteilung 1: Originale, Reihe B:
Hygiene,
Krankenhaushygiene, Betriebshygiene, Praeventive Medizin. (Stuttgart,
Fed.
Rep. Ger.) V.155-169, 1971-1979. For publisher information, see ZAOMDC.
Volume(issue)/page/year: 166,113,1978
TOXICOLOGY REVIEW
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: (Suppl 2),69,1977
TOXICOLOGY REVIEW
PHRPA6 Public Health Reports. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11878- Volume(issue)/page/year:
41,1357,1926
TOXICOLOGY REVIEW
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
41,616,1980
TOXICOLOGY REVIEW
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For
publisher
information, see JTCTDW. Volume(issue)/page/year: 11,531,1977
TOXICOLOGY REVIEW
BNYMAM Bulletin of the New York Academy of Medicine.
(New York Academy
of
Medicine, 2 E. 103rd St., New York, NY 10029)
Volume(issue)/page/year: 54,413,1978
Ser 2: V.1-
TOXICOLOGY REVIEW
KRANAW Krankheitsforschung. (Leipzig, Ger. Dem. Rep.)
Discontinued. Volume(issue)/page/year: 9,403,1932
1925-
V.1-9, 1925-32.
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD:air-CL 25 ppm (80 mg/m3) (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,22,1971
OSHA PEL (Construc):see CFR 29,1926.1128
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Fed Cont):CL 25 ppm (80 mg/m3) (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
OSHA-cancer hazard
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
52,34460,1987
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 5 ppm (16 mg/m3);Carcinogen JAN 1993
OEL-AUSTRIA: Skin, Carcinogen, JAN1999
OEL-BELGIUM:TWA 10 ppm (32 mg/m3);Carcinogen JAN 1993
OEL-DENMARK: TWA 5 ppm (16 mg/m3), Skin, JAN1999
OEL-FINLAND:TWA 5 ppm (15 mg/m3);STEL 10 ppm (30 mg/m3);Skin;Carcinogen
JAN
1993
OEL-JAPAN: OEL 10 ppm (32 mg/m3), Group 1 Carcinogen, JAN1999
OEL-GERMANY;Skin;Carcinogen JAN 1993
OEL-HUNGARY:STEL 5 mg/m3;Skin;Carcinogen JAN 1993
OEL-INDIA:TWA 10 ppm (30 mg/m3);Carcinogen JAN 1993
OEL-POLAND: MAC(TWA) 10 mg/m3, MAC(STEL) 40 mg/m3, JAN1999
OEL-JAPAN:TWA 10 ppm (32 mg/m3);STEL 25 ppm (80 mg/m3);Carcinogen JAN
1993
OEL-THE NETHERLANDS:TWA 10 ppm (30 mg/m3);Skin JAN 1993
OEL-THE PHILIPPINES:TWA 25 ppm (80 mg/m3);Skin JAN 1993
OEL-RUSSIA:TWA 10 ppm (5 mg/m3);STEL 25 ppm (15 mg/m3);Skin;Carcinogen
JAN
1993
OEL-SWEDEN:TWA 1 ppm (3 mg/m3);STEL 5 ppm (16 mg/m3);Skin;Carcinogen JAN
1993
OEL-SWITZERLAND:TWA 5 ppm (16 mg/m3);Skin;Carcinogen JAN 1993
OEL-THAILAND:TWA 10 ppm (30 mg/m3);STEL 25 ppm (75 mg/m3) JAN 1993
OEL-TURKEY:TWA 20 ppm (64 mg/m3);Skin JAN 1993
OEL-UNITED KINGDOM:TWA 10 ppm (30 mg/m3) JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO BENZENE-air:8H CA TWA 0.1 ppm;CL 1 ppm/15M
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 09070
No. of Facilities: 11184 (estimated)
No. of Industries: 126
No. of Occupations: 106
No. of Employees: 147583 (estimated)
NOES - National Occupational
NOES Hazard Code - 09070
No. of Facilities: 10054
No. of Industries: 92
No. of Occupations: 117
No. of Employees: 272275
No. of Female Employees:
Exposure Survey (1983)
(estimated)
(estimated)
143066 (estimated)
*** STATUS IN U.S. ***
ATSDR TOXICOLOGY PROFILE
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB/89/209464/AS
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Positive: In vitro cytogenetics-human
lymphocyte
EPA GENETOX PROGRAM 1988, Positive: In vivo cytogenetics-human lymphocyte
EPA GENETOX PROGRAM 1988, Positive: Mammalian micronucleus; Sperm
morphology-mouse
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE; In vitro
SCE-human lymphocytes
EPA GENETOX PROGRAM 1988, Negative: In vitro SCE-human
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Hydrocarbons, BP 36-126 degree C, 1500
NIOSH Analytical Method, 1994: Benzene, by portable GC, 3700
NIOSH Analytical Method, 1994: Hydrocarbons, aromatic, 1501
NTP Carcinogenesis Studies (gavage);clear evidence:mouse,rat
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-289,1986
NTP 8th Annual Report on Carcinogens, 1998: Known to be human carcinogen
NTP Carcinogenesis studies; selected, May 1999
OSHA ANALYTICAL METHOD #12
BENZENESULFONAMIDE
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
BEILSTEIN REFERENCE NO. :
REFERENCE
:
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
WISWESSER LINE NOTATION :
COMPOUND DESCRIPTOR
:
SYNONYMS/TRADE NAMES :
* Benzenesulphonamide
* Benzolsulfonamide
* Benzosulfonamide
* M and B 7973
DA9380000
Benzenesulfonamide
98-10-2
1100566
4-11-00-00050 (Beilstein Handbook Reference)
199710
11
C6-H7-N-O2-S
157.20
ZSWR
Drug
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 991 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,1073,1986
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 740 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 19(12),47,1975
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington,
DC
20037) V.61963- Volume(issue)/page/year: 8,548,1965
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 36(6),19,1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 36(6),19,1971
(V/O
(V/O
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5280 mg/kg/30D-I
TOXIC EFFECTS :
Liver - liver function tests impaired
Blood - changes in leukocyte (WBC) count
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 51(1),88,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 12180 mg/kg/9W-I
TOXIC EFFECTS :
Liver - liver function tests impaired
Blood - changes in erythrocyte (RBC) count
Related to Chronic Data - death
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 36(6),19,1971
(V/O
(V/O
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 636 mg/kg/30W-I
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 36(6),19,1971
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - E0266
No. of Facilities: 126 (estimated)
No. of Industries: 4
No. of Occupations: 6
No. of Employees: 2957 (estimated)
No. of Female Employees: 1600 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
BENZENESULFONIC ACID
RTECS NUMBER
: DB4200000
CHEMICAL NAME
: Benzenesulfonic acid
CAS REGISTRY NUMBER
: 98-11-3
BEILSTEIN REFERENCE NO. : 0742513
REFERENCE
: 4-11-00-00027 (Beilstein Handbook Reference)
LAST UPDATED
: 199710
DATA ITEMS CITED
: 10
MOLECULAR FORMULA
: C6-H6-O3-S
MOLECULAR WEIGHT
: 158.18
WISWESSER LINE NOTATION : WSQR
COMPOUND DESCRIPTOR
: Primary Irritant
SYNONYMS/TRADE NAMES :
* 17-120A
* Benzenemonosulfonic acid
* Benzene sulphonic acid
* Besylic acid
* Kyselina benzensulfonova
* Phenylsulfonic acid
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Open irritation test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 ug/24H
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
23,95,1962
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2 mg/24H
REACTION SEVERITY
: Severe
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,1053,1986
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 250 ug/24H
REACTION SEVERITY
: Severe
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,1053,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 890 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
23,95,1962
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LDLo - Lowest published lethal dose
: Administration onto the skin
: Mammal - cat
DOSE/DURATION
: 10 gm/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - muscle weakness
Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 84,358,1945
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - wild bird species
DOSE/DURATION
: 75 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
21,315,1972
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X7434
No. of Facilities: 28 (estimated)
No. of Industries: 2
No. of Occupations: 2
No. of Employees: 3164 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
BENZENESULFONIC ACID SODIUM
RTECS NUMBER
: DB7350000
CHEMICAL NAME
: Benzenesulfonic acid, sodium salt
CAS REGISTRY NUMBER
: 515-42-4
LAST UPDATED
: 199709
DATA ITEMS CITED
: 4
MOLECULAR FORMULA
: C6-H5-O3-S.Na
MOLECULAR WEIGHT
: 180.16
WISWESSER LINE NOTATION : WSQR &-NASYNONYMS/TRADE NAMES :
* Dispersant GN
* Sodium benzene monosulfate
* Sodium benzenesulfonate
* Sodium benzosulfonate
* Sodium phenylsulfonate
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 9378 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SKEZAP Shokuhin Eiseigaku Zasshi. Food Hygiene Journal. (Nippon
Shokuhin
Eisei Gakkai c/o Shokuhin Eisei Senta, 2-6-1 Jingumae, Shibuya-ku, Tokyo
150, Japan) V.11960- Volume(issue)/page/year: 4,15,1963
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 81979
No. of Facilities: 4884 (estimated)
No. of Industries: 16
No. of Occupations: 19
No. of Employees: 24586 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 81979
No. of Facilities: 12 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 743 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BENZENESULFONYL CHLORIDE
RTECS NUMBER
: DB8750000
CHEMICAL NAME
: Benzenesulfonyl chloride
CAS REGISTRY NUMBER
: 98-09-9
OTHER CAS REGISTRY NOS. : 114415-79-1
BEILSTEIN REFERENCE NO. : 0606926
REFERENCE
: 4-11-00-00049 (Beilstein Handbook Reference)
LAST UPDATED
: 199710
DATA ITEMS CITED
: 11
MOLECULAR FORMULA
: C6-H5-Cl-O2-S
MOLECULAR WEIGHT
: 176.62
WISWESSER LINE NOTATION : WSGR
SYNONYMS/TRADE NAMES :
* Benzene sulfonechloride
* Benzenesulfonic chloride
* Benzenesulfonic (acid) chloride
* Benzenosulfochlorek
*
*
*
*
*
Benzenosulphochloride
Benzolsulfochloride
BSC-refine D
Phenylsulfonyl chloride
RCRA waste number U020
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1960 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
MEPAAX Medycyna Pracy. Industrial Medicine. (Ars-Polona, POB 1001,
00-068
Warsaw 1, Poland) V.11950- Volume(issue)/page/year: 20,513,1969
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1870 mg/m3/1H
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - chromodacryorrhea
Behavioral - changes in motor activity (specific assay)
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection
Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)
Volume(issue)/page/year: OTS0510391
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 76 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
MEPAAX Medycyna Pracy. Industrial Medicine. (Ars-Polona, POB 1001,
00-068
Warsaw 1, Poland) V.11950- Volume(issue)/page/year: 20,513,1969
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 828 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 36(6),19,1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
(V/O
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 828 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 36(6),19,1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 828 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 36(6),19,1971
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 1 mg/m3;Skin JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - A1145
No. of Facilities: 17 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 851 (estimated)
No. of Female Employees: 187 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
BENZENETETRACARBONITRILE (1,2,4,5-)
RTECS NUMBER
: DB9100000
CHEMICAL NAME
: 1,2,4,5-Benzenetetracarbonitrile
CAS REGISTRY NUMBER
: 712-74-3
LAST UPDATED
: 199410
DATA ITEMS CITED
: 1
MOLECULAR FORMULA
: C10-H2-N4
MOLECULAR WEIGHT
: 178.16
WISWESSER LINE NOTATION : NCR BCN DCN ECN
SYNONYMS/TRADE NAMES :
* 1,2,4,5-Benzentetrakarbonitril
(V/O
(V/O
*
*
*
*
*
*
*
*
*
1,2,4,5-Benzenetetranitrile
Pyromellitic acid tetranitrile
Pyromellitic nitrile
Pyromellitic tetranitrile
Pyromellitonitrile
Pyromellitotetranitrile
Tetracyanobenzene
sym-Tetracyanobenzene
1,2,4,5-Tetracyanobenzene
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 28 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.
Toxicology of New Industrial Chemical Substances. For English
translation,
see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.11961Volume(issue)/page/year: 7,180,1965
BENZENETETRACARBOXYLIC ACID (1,2,4,5)
RTECS NUMBER
: DB9275000
CHEMICAL NAME
: 1,2,4,5-Benzenetetracarboxylic acid
CAS REGISTRY NUMBER
: 89-05-4
BEILSTEIN REFERENCE NO. : 1887659
REFERENCE
: 4-09-00-03804 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C10-H6-O8
MOLECULAR WEIGHT
: 254.16
WISWESSER LINE NOTATION : QVR BVQ DVQ EVQ
SYNONYMS/TRADE NAMES :
* Pyromellitic acid
* 1,2,4,5-Tetracarboxybenzene
* USAF XR-20
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BENZENETRIAMINE DIHYDROCHLORIDE (1,2,4-)
RTECS NUMBER
: DC1953000
CHEMICAL NAME
: 1,2,4-Benzenetriamine, dihydrochloride
CAS REGISTRY NUMBER
: 615-47-4
LAST UPDATED
: 199701
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C6-H9-N3.2Cl-H
MOLECULAR WEIGHT
: 196.10
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* 1,2,4-Triaminobenzene dihydrochloride
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BENZENETRICARBOXYLIC ACID (1,2,4-)
RTECS NUMBER
: DC1980000
CHEMICAL NAME
: 1,2,4-Benzenetricarboxylic acid
CAS REGISTRY NUMBER
: 528-44-9
BEILSTEIN REFERENCE NO. : 2214815
REFERENCE
: 4-09-00-03746 (Beilstein Handbook Reference)
LAST UPDATED
: 199709
DATA ITEMS CITED
: 4
MOLECULAR FORMULA
: C9-H6-O6
MOLECULAR WEIGHT
: 210.15
WISWESSER LINE NOTATION : QVR BVQ DVQ
SYNONYMS/TRADE NAMES :
* 1,3,4-Benzenetricarboxylic acid
* 1,4,5-Benzenetricarboxylic acid
* 4-Carboxyphthalic acid
* 1,2,4-Tricarboxybenzene
* Trimellitic acid
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 18(7),57,1974
*** REVIEWS ***
TOXICOLOGY REVIEW
BPCT** Progress Report from the Environmental Protection Agency to NIOSH
on
Benzenepolycarboxylates, 1974
Volume(issue)/page/year: -,183,1974
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83703
No. of Facilities: 82 (estimated)
No. of Industries: 3
No. of Occupations: 4
No. of Employees: 1278 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BENZETHONIUM CHLORIDE
RTECS NUMBER
CHEMICAL NAME
: BO7175000
: Ammonium,
benzyldimethyl(2-(2-(p-(1,1,3,3-tetramethylbutyl)phen
oxy)ethoxy)ethyl)-, chloride
CAS REGISTRY NUMBER
: 121-54-0
LAST UPDATED
: 199904
DATA ITEMS CITED
: 26
MOLECULAR FORMULA
: C27-H42-N-O2.Cl
MOLECULAR WEIGHT
: 448.15
WISWESSER LINE NOTATION : 1X1&1&1X1&1&R DO2O2K1&1&1R &Q &G
COMPOUND DESCRIPTOR
: Agricultural Chemical
Tumorigen
Drug
Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* Anti-germ 77
* Antiseptol
* Antiseptol (quarternary compound)
* Benzethonium chloride
* Benzethonium chloride 1622
* Benzyldimethyl-p-(1,1,3,3-tetramethylbutyl)phenoxyethoxy-ethylammonium
chloride
*
Benzyldimethyl(2-(2-(p-(1,1,3,3-tetramethylbutyl)phenoxy)ethoxy)ethyl)am
monium chloride
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
BZT
Diapp
Diisobutylphenoxyethoxyethyl dimethyl benzyl ammonium chloride
Disilyn
Hyamine
Hyamine 1622
NCI-C61494
p-tert-Octylphenoxyethoxyethyldimethylbenzylammonium chloride
Phemeride
Phemerol
Phemerol chloride
Phemithyn
Polymine D
Quatrachlor
Solamin
Solamine
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 30 ug
REACTION SEVERITY
: Severe
REFERENCE :
PSTGAW Proceedings of the Scientific Section of the Toilet Goods
Association. (Washington, DC) No.1-48, 1944-67. Discontinued.
Volume(issue)/page/year: 20,16,1953
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 368 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.11903/04Volume(issue)/page/year: 120,511,1965
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 16500 ug/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
FSDZD4 Fukuoka Shika Daigaku Gakkai Zasshi. Journal of Fukuoka Dental
College. (700 Ta, O-aza, Sawara-ku, Fukuoka 814-01, Japan) V.11974Volume(issue)/page/year: 9,729,1983
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 119 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB195-158
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 19 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Kidney, Ureter, Bladder - hematuria
Blood - changes in cell count (unspecified)
REFERENCE :
SCHSAV Soap and Chemical Specialties. (New York, NY) V.30-47, 1954-71.
For
publisher information, see SCCSC8. Volume(issue)/page/year: 30,147,1954
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 420 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and
Biologicals",
11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989
Volume(issue)/page/year:
11,167,1989
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 338 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.11903/04Volume(issue)/page/year: 120,511,1965
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 7813 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert,
Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993.
Discontinued.
Volume(issue)/page/year: 4(5),65,1985
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 30 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific
Edition. (Washington, DC) V.29-49, 1940-60. For publisher information,
see
JPMSAE. Volume(issue)/page/year: 40,267,1951
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 182 gm/kg/2Y-C
TOXIC EFFECTS :
Gastrointestinal - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 109,422,1953
V.1-
1909/10-
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 60 mg/kg/16D-I
TOXIC EFFECTS :
Endocrine - changes in thymus weight
Skin and Appendages - dermatitis, other (after systemic exposure)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-438,1995
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 203 mg/kg/13W-I
TOXIC EFFECTS :
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-438,1995
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 312 mg/kg/1Y-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For
publisher
information, see JTCTDW. Volume(issue)/page/year: 4(2),185,1971
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1200 mg/kg/16D-I
TOXIC EFFECTS :
Cardiac - changes in heart weight
Endocrine - changes in thymus weight
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-438,1995
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 101 mg/kg/13W-I
TOXIC EFFECTS :
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-438,1995
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 104 mg/kg/1Y-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Skin and Appendages - tumors
Tumorigenic - tumors at site of application
REFERENCE :
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81.
publisher
information, see JTCTDW. Volume(issue)/page/year: 4,185,1971
For
** MUTATION DATA **
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 1500 ng/well
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
133,161,1984
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
SHIGAZ Shigaku.
: Sister chromatid exchange
: Rodent - hamster Embryo
: 1 mg/L
Ondotology.
(Nippon Shika Daigaku Shigakkai, 1-9-20
Fujimi, Chiyodaku, Tokyo 102, Japan) V.38Volume(issue)/page/year: 74,1365,1987
1949-
*** REVIEWS ***
TOXICOLOGY REVIEW
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert,
Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993.
Discontinued.
Volume(issue)/page/year: 4(5),65,1985
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 25830
No. of Facilities: 2975 (estimated)
No. of Industries: 15
No. of Occupations: 26
No. of Employees: 26546 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 25830
No. of Facilities: 1657 (estimated)
No. of Industries: 11
No. of Occupations: 20
No. of Employees: 26949 (estimated)
No. of Female Employees: 18054 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NTP Carcinogenesis Studies (dermal):no evidence:mouse,rat
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-438,1995
BENZHYDROL
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
BEILSTEIN REFERENCE NO. :
REFERENCE
:
(Research
DC7452000
Benzhydrol
91-01-0
1424379
4-06-00-04648 (Beilstein Handbook Reference)
LAST UPDATED
: 199712
DATA ITEMS CITED
: 6
MOLECULAR FORMULA
: C13-H12-O
MOLECULAR WEIGHT
: 184.25
WISWESSER LINE NOTATION : QYR&R
SYNONYMS/TRADE NAMES :
* Benzhydryl alcohol
* Benzohydrol
* Diphenyl carbinol
* Diphenylmethanol
* Diphenylmethyl alcohol
* Hydroxydiphenylmethane
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 17,713,1979
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 17,713,1979
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 24,405,1925
V.1-
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83171
No. of Facilities: 21 (estimated)
No. of Industries: 1
No. of Occupations: 2
1909/10-
No. of Employees: 249 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
BENZHYDRYLAMINE HYDROCHLORIDE POLYMER
RTECS NUMBER
: DA4407300
CHEMICAL NAME
: Benzenemethanamine, alpha-phenylCAS REGISTRY NUMBER
: 91-00-9
LAST UPDATED
: 199712
DATA ITEMS CITED
: 1
MOLECULAR FORMULA
: C13-H13-N
MOLECULAR WEIGHT
: 183.27
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
* Aminodiphenylmethane
* alpha-Aminodiphenylmethane
* Benzhydrylamine
* (Diphenylmethyl)amine
* 1,1-Diphenylmethylamine
* Methylamine, 1,1-diphenyl* alpha-Phenylbenzenemethanamine
* alpha-Phenylbenzylamine
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation).
Translation
of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)
1967- Volume(issue)/page/year: 28,163,1994
BENZIDINE
RTECS NUMBER
: DC9625000
CHEMICAL NAME
: Benzidine
CAS REGISTRY NUMBER
: 92-87-5
BEILSTEIN REFERENCE NO. : 0742770
REFERENCE
: 4-13-00-00364 (Beilstein Handbook Reference)
LAST UPDATED
: 199907
DATA ITEMS CITED
: 122
MOLECULAR FORMULA
: C12-H12-N2
No.1-
MOLECULAR WEIGHT
: 184.26
WISWESSER LINE NOTATION : ZR DR DZ
COMPOUND DESCRIPTOR
: Tumorigen
Mutagen
Human
SYNONYMS/TRADE NAMES :
* Benzidin
* Benzidina
* Benzidine
* Benzydyna
* p,p-Bianiline
* 4,4'-Bianiline
* (1,1'-Biphenyl)-4,4'-diamine
* 4,4'-Biphenyldiamine
* Biphenyl, 4,4'-diamino* 4,4'-Biphenylenediamine
* C.I. 37225
* C.I. Azoic Diazo Component 112
* p,p'-Diaminobiphenyl
* 4,4'-Diaminobiphenyl
* 4,4'-Diamino-1,1'-biphenyl
* p-Diaminodiphenyl
* 4,4'-Diaminodiphenyl
* p,p'-Dianiline
* 4,4'-Diphenylenediamine
* Fast Corinth Base B
* NCI-C03361
* RCRA waste number U021
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 309 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB214-270
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 214 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB214-270
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Intraperitoneal
Rodent - mouse
110 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
1,682,1981
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie.
(Leipzig,
Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see
NSAPCC.
Volume(issue)/page/year: 58,167,1907
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie.
(Leipzig,
Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see
NSAPCC.
Volume(issue)/page/year: 58,167,1907
** TUMORIGENIC DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 17600 ug/m3/14Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Kidney, Ureter, Bladder - hematuria
Kidney, Ureter, Bladder - tumors
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle
St.,
NW, Washington, DC 20016) V.11960- Volume(issue)/page/year:
27,1,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 108 mg/kg/27D-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
28,924,1968
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 10 mg/m3/56W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
Blood - leukemia
REFERENCE :
BEXBAN Bulletin of Experimental Biology and Medicine (English
Translation).
Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY
10013) V.411956- Volume(issue)/page/year: 69,68,1970
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1200 mg/kg/26W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
VOONAW Voprosy Onkologii. Problems of Oncology. For English
translation,
see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10,
1928-37; V.11955- Volume(issue)/page/year: 10(5),50,1964
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intratracheal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 315 mg/kg/34W
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
Skin and Appendages - tumors
REFERENCE :
BEXBAN Bulletin of Experimental Biology and Medicine (English
Translation).
Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY
10013) V.411956- Volume(issue)/page/year: 69,68,1970
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 8400 mg/kg/35W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Liver - tumors
REFERENCE :
VOONAW Voprosy Onkologii. Problems of Oncology. For English
translation,
see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10,
1928-37; V.11955- Volume(issue)/page/year: 17(5),61,1971
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - hamster
DOSE/DURATION
: 75 mg/kg/3Y-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
REFERENCE :
85DAAC "Bladder Cancer, A Symposium, Fifth Inter-American Conference on
Toxicology and Occupational Medicine, Coral Gables, FL," Lampe, K.F., et
al., eds., Coral Gables, FL, Aesculapius Pub., 1966
Volume(issue)/page/year:
5,129,1966
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1620 gm/kg/45W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
REFERENCE :
AICCA6 Acta Unio Internationalis Contra Cancrum. (Louvain, Belgium)
V.1-20,
1936-64. For publisher information, see IJCNAW. Volume(issue)/page/year:
7,46,1950
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 850 mg/kg/32W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
Skin and Appendages - tumors
REFERENCE :
VOONAW Voprosy Onkologii. Problems of Oncology. For English
translation,
see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10,
1928-37; V.11955- Volume(issue)/page/year: 20(2),53,1974
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 800 mg/kg/60W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Sense Organs and Special Senses (Ear) - effect, not otherwise specified
Blood - tumors
REFERENCE :
VOONAW Voprosy Onkologii. Problems of Oncology. For English
translation,
see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10,
1928-37; V.11955- Volume(issue)/page/year: 20(8),69,1974
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TD - Toxic dose (other than lowest)
Subcutaneous
Rodent - rat
2025 mg/kg/27W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Sense Organs and Special Senses (Ear) - effect, not otherwise specified
Liver - tumors
REFERENCE :
CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment
Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.11948Volume(issue)/page/year: 3,789,1950
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 25560 ng/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
REFERENCE :
EKSODD Eksperimental'naya Onkologiya. Experimental Oncology.
Mezhdunarodnaya Kniga, 113095 Mosow, USSR) V.11979Volume(issue)/page/year: 9(4),73,1987
(V/O
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 400 ng/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
175,11,1986
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 567 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
192,239,1987
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 100 ug/plate
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
1,387,1981
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 1 mg/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
54,101,1978
TYPE OF TEST
TEST SYSTEM
: Phage inhibition capacity
: Bacteria - Escherichia coli
DOSE/DURATION
: 100 mmol/L
REFERENCE :
MDMIAZ Medycyna Doswiadczalna i Mikrobiologia. For English translation,
see
EXMMAV. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.11949Volume(issue)/page/year: 31,11,1979
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Bacteria - Bacillus subtilis
DOSE/DURATION
: 2 mg/disc
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
1,175,1981
TYPE OF TEST
: Specific locus test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 5 mmol/L/48H
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
222,359,1989
TYPE OF TEST
: Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE
: Parenteral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 5 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
56,31,1977
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 100 mg/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
1,502,1981
TYPE OF TEST
: Gene conversion and mitotic recombination
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 100 mg/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
1,491,1981
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
: Sex chromosome loss and nondisjunction
: Yeast - Saccharomyces cerevisiae
: 50 mg/L
PMRSDJ Progress in Mutation Research.
(Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017)
Volume(issue)/page/year:
1,468,1981
V.1-
1981-
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Fish - not otherwise specified
DOSE/DURATION
: 10 mg/kg
REFERENCE :
CYTBAI Cytobios. (Faculty Press, 88 Regent St., Cambridge, UK)
1969Volume(issue)/page/year: 47,147,1986
V.1-
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Fish - not otherwise specified
DOSE/DURATION
: 10 mg/kg
REFERENCE :
CBPCEE Comparative Biochemistry and Physiology, C: Pharmacology,
Toxicology
and Endocrinology. (Elsevier Science, 660 White Plains Rd., Tarrytown, NY
10591) V.741983- Volume(issue)/page/year: 82,489,1985
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Human Fibroblast
DOSE/DURATION
: 3 mmol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 7,267,1985
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 30 umol/L
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United
States
of America. (National Academy of Sciences, Printing & Pub. Office, 2101
Constitution Ave., Washington, DC 20418) V.11915Volume(issue)/page/year: 85,3513,1988
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Human Liver
DOSE/DURATION
: 10 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
206,91,1988
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Human HeLa cell
DOSE/DURATION
: 100 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
38,2621,1978
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Human Fibroblast
DOSE/DURATION
: 160 ug/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
1,528,1981
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human HeLa cell
DOSE/DURATION
: 600 umol/L/30M (Continuous)
REFERENCE :
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest
South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
Volume(issue)/page/year: 2(1),65,1978
TYPE OF TEST
:
ROUTE OF EXPOSURE
:
TEST SYSTEM
:
DOSE/DURATION
:
REFERENCE :
POLEAQ Polski Tygodnik
POB
1001, 00 068 Warsaw 1,
35,53,1980
Sister chromatid exchange
Inhalation
Human - man
7 ug/m3/27W
Lekarski.
Poland)
Polish Medical Weekly.
V.1-
1946-
(Ars Polona,
Volume(issue)/page/year:
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 2 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
241,109,1990
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Subcutaneous
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 410 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
40,43,1976
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 25 mg/kg
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 57,217,1989
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 3 mmol/L
REFERENCE :
SinJF# Personal Communication from J.F. Sina, Merck Institute for
Therapeutic Research, West Point, PA 19486, Oct. 26, 1982
Volume(issue)/page/year: 26OCT1982
TYPE OF TEST
: DNA damage
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 63 mg/kg
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 6,1285,1985
TYPE OF TEST
: DNA adduct
ROUTE OF EXPOSURE
: Parenteral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 11600 ug/kg
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
42,2678,1982
TYPE OF TEST
: DNA damage
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 200 mg/kg
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 4,667,1982
TYPE OF TEST
: Unscheduled DNA synthesis
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 200 mg/kg
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 4,553,1982
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 100 nmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
136,255,1984
TYPE OF TEST
: DNA inhibition
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 100 umol/kg
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 8,1433,1987
TYPE OF TEST
: Body fluid assay
TEST SYSTEM
: Rodent - rat Bacteria - Salmonella typhimurium
DOSE/DURATION
: 250 umol/kg
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 21,223,1981
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 12500 ug/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
1,570,1981
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 250 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
182,309,1987
TYPE OF TEST
: Host-mediated assay
TEST SYSTEM
: Rodent - rat Bacteria - Salmonella typhimurium
DOSE/DURATION
: 1 mmol/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
93,317,1982
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 6400 ug/kg
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
1,686,1981
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 300 mg/kg
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year:
2,267,1987
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - mouse Embryo
DOSE/DURATION
: 2500 ug/L
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis.
Inc.,
41 E. 11th St., New York, NY 10003) V.11980Volume(issue)/page/year:
3,101,1983
TYPE OF TEST
ROUTE OF EXPOSURE
: DNA damage
: Intraperitoneal
(Alan R. Liss,
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 150 mg/kg
REFERENCE :
BSIBAC Bolletino della Societe Italiana di Biologia Sperimentale. (Casa
Editrice Idelson, Via A. de Gasperi, 55, 80133 Naples, Italy) V.2- 1927Volume(issue)/page/year: 56,1673,1980
TYPE OF TEST
: DNA adduct
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 9600 ug/kg
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
42,2678,1982
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Rodent - mouse Liver
DOSE/DURATION
: 60 umol/L
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 62,947,1979
TYPE OF TEST
: DNA inhibition
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 20 gm/kg
REFERENCE :
ARGEAR Archiv fuer Geschwulstforschung. (VEB Verlag Volk und Gesundheit
Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.11949Volume(issue)/page/year: 51,605,1981
TYPE OF TEST
: DNA inhibition
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 200 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
46,305,1977
TYPE OF TEST
: Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 25 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
268,255,1992
TYPE OF TEST
: Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 100 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
319,19,1993
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 25 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
320,69,1994
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 100 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
320,69,1994
TYPE OF TEST
: Sister chromatid exchange
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 7700 ug/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
108,225,1983
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 500 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
125,291,1984
TYPE OF TEST
: Host-mediated assay
TEST SYSTEM
: Rodent - mouse Bacteria - Escherichia coli
DOSE/DURATION
: 220 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
272,161,1992
TYPE OF TEST
: Specific locus test
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 600 mg/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
1,594,1981
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 50 ug/L
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland)
3,45,1977
V.1-
1975- Volume(issue)/page/year:
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - hamster Kidney
DOSE/DURATION
: 80 ug/L
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.11947Volume(issue)/page/year:
37,873,1978
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 100 umol/L/2H
REFERENCE :
BBRCA9 Biochemical and Biophysical Research Communications. (Academic
Press, Inc., 1 E. First St., Duluth, MN 55802) V.11959Volume(issue)/page/year: 72,732,1976
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - hamster Liver
DOSE/DURATION
: 20 nmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
136,255,1984
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 160 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
10(Suppl 10),1,1987
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 5 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
10(Suppl 10),1,1987
TYPE OF TEST
: DNA adduct
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Mammal - dog
DOSE/DURATION
: 60 umol/kg
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 49,125,1983
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
: Mutation test systems - not otherwise specified
: Mammal - dog Cells - not otherwise specified
: 100 umol/L
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
44,1893,1984
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Mammal - dog Cells - not otherwise specified
DOSE/DURATION
: 100 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
44,1893,1984
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - rabbit Cells - not otherwise specified
DOSE/DURATION
: 100 umol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 8,401,1987
TYPE OF TEST
: Unscheduled DNA
TEST SYSTEM
: Rodent - rabbit
DOSE/DURATION
: 1 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger
Sts., Philadelphia, PA 19106) V.143,3120,1983
synthesis
Liver
Building, Suit 816, 6th & Chestnut
1941- Volume(issue)/page/year:
*** REVIEWS ***
ACGIH TLV-Confirmed human carcinogen (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Human Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 1,80,1972
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 1,80,1972
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 29,149,1982
IARC Cancer Review:Human Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 29,149,1982
IARC Cancer Review:Group 1
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,123,1987
TOXICOLOGY REVIEW
EAHB** Environmental and Health Criteria for Benzidine. Meeting of DHEW
Committee to Coordinate Toxicology and Related Programs, Feb. 15, 1974 at
Sterling Forest, NY Volume(issue)/page/year: -,38,1974
TOXICOLOGY REVIEW
KHZHAZ Khimiya i Zhizn. Chemistry and Life. (V/O Mezhdunarodnaya Kniga,
113095 Moscow, USSR) V.11965- Volume(issue)/page/year:
12(2),85,1976
TOXICOLOGY REVIEW
ADCSAJ Advances in Chemistry Series. (American Chemical Soc.,
Distribution
Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037)
1950- Volume(issue)/page/year: 13,271,1970
No.1-
TOXICOLOGY REVIEW
BLFSBY Basic Life Sciences. (Plenum Pub. Corp., 223 Spring St., New
York,
NY 10003) V.11973- Volume(issue)/page/year: 24,253,1983
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD:skin-HUMAN CARCINOGEN, NO ASSIGNED TWA
DTLWS* "Documentation of the Threshold Limit Values for Substances in
Workroom Air," Supplements. For publisher information, see 85INA8.
Volume(issue)/page/year: 3,11,1973
OSHA PEL (Gen Indu):see CFR 29,1910.1010
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):see CFR 29,1926.1110
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926,55,1994
OSHA PEL (Shipyard):see CFR 29,1915.1010
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA-cancer suspect agent
CFRGBR Code of Federal Regulations.
(U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402)
29,1910.1010,1987
Volume(issue)/page/year:
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA;(Prohibited) Skin;Carcinogen JAN 1993
OEL-AUSTRIA: Skin, Carcinogen, JAN1999
OEL-FINLAND;Carcinogen JAN 1993
OEL-GERMANY;Skin;Carcinogen JAN 1993
OEL-THE NETHERLANDS;Skin JAN 1993
OEL-SWEDEN;Carcinogen JAN 1993
OEL-SWITZERLAND;Carcinogen JAN 1993
OEL-POLAND: MAC(TWA) 0 mg/m3, MAC(STEL) 0 mg/m3, JAN1999
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO BENZIDINE-air:CA use 29 CFR 1910.1010
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 09830
No. of Facilities: 263 (estimated)
No. of Industries: 4
No. of Occupations: 5
No. of Employees: 1166 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 09830
No. of Facilities: 252 (estimated)
No. of Industries: 3
No. of Occupations: 8
No. of Employees: 1554 (estimated)
No. of Female Employees: 426 (estimated)
*** STATUS IN U.S. ***
ATSDR TOXICOLOGY PROFILE
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB/90/168204/AS
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; SHE-clonal
assay
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-mouse embryo
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Positive: Mammalian micronucleus; Histidine
reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: In vitro UDS in rat liver
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse
EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9; In vitro
UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Positive: CHO gene mutation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Benzidine, 5509; in urine, 8306
NTP 8th Annual Report on Carcinogens, 1998: Known to be human carcinogen
OSHA ANALYTICAL METHOD #ID-65
BENZIDINE DIHYDROCHLORIDE
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
WISWESSER LINE NOTATION :
COMPOUND DESCRIPTOR
:
DD0600000
Benzidine, dihydrochloride
531-85-1
199710
31
C12-H12-N2.2Cl-H
257.18
ZR DR DZ &GH 2
Tumorigen
Drug
Mutagen
SYNONYMS/TRADE NAMES :
* (1,1'-Biphenyl)-4,4'-diamine, dihydrochloride
* Dihidrocloruro de benzidina
*** HEALTH HAZARD DATA ***
** TUMORIGENIC DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
: TDLo - Lowest published toxic dose
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 62 mg/kg/4W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Endocrine - tumors
Skin and Appendages - tumors
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 2,747,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3360 mg/kg/80W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
64,171,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - hamster
DOSE/DURATION
: 75 mg/kg/3Y-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
REFERENCE :
85DAAC "Bladder Cancer, A Symposium, Fifth Inter-American Conference on
Toxicology and Occupational Medicine, Coral Gables, FL," Lampe, K.F., et
al., eds., Coral Gables, FL, Aesculapius Pub., 1966
Volume(issue)/page/year:
5,129,1966
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1600 mg/kg/84W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
Endocrine - tumors
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
35,2814,1975
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 5040 mg/kg/60W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.164,171,1982
1959-
Volume(issue)/page/year:
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 8064 mg/kg/80W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Liver - tumors
REFERENCE :
EJCAAH European Journal of Cancer. (Oxford, UK) V.1-17(6), 1965-1981.
For
publisher information, see EJCODS. Volume(issue)/page/year: 16,1205,1980
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1680 mg/kg/40W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
REFERENCE :
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia,
Warner-Lambert
Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106)
V.6(3/4)1978- Volume(issue)/page/year: 9,1,1981
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 13440 mg/kg/1Y-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 4,69,1984
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 100 nmol/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
136,33,1984
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 250 ug/well
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
133,161,1984
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 20 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
89,95,1981
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Human HeLa cell
DOSE/DURATION
: 20 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
89,95,1981
TYPE OF TEST
: DNA damage
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 250 mg/kg
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
38,1589,1978
TYPE OF TEST
: DNA damage
ROUTE OF EXPOSURE
: Subcutaneous
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 250 mg/kg
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
38,1589,1978
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 3 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
216,101,1989
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 300 mg/kg
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year:
3,437,1988
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 400 mg/kg/48H (Continuous)
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
234,187,1990
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 30 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
12(Suppl 13),37,1988
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 25 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
12(Suppl 13),103,1988
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 200 umol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 8,515,1986
TYPE OF TEST
: Sister chromatid exchange
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - hamster
DOSE/DURATION
: 12500 ug/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
113,33,1983
TYPE OF TEST
: Sister chromatid exchange
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - hamster
DOSE/DURATION
: 12500 ug/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
113,33,1983
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 20 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
94,449,1982
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83072
No. of Facilities: 64 (estimated)
No. of Industries: 2
No. of Occupations: 2
No. of Employees: 598 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 83072
No. of Facilities: 103 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 2987 (estimated)
No. of Female Employees: 2464 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; Cell
transform.-SA7/SHE
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
BENZIL
RTECS NUMBER
: DD1925000
CHEMICAL NAME
: Benzil
CAS REGISTRY NUMBER
: 134-81-6
LAST UPDATED
: 199710
DATA ITEMS CITED
: 5
MOLECULAR FORMULA
: C14-H10-O2
MOLECULAR WEIGHT
: 210.24
WISWESSER LINE NOTATION : RVVR
COMPOUND DESCRIPTOR
: Primary Irritant
SYNONYMS/TRADE NAMES :
* Bibenzoyl
* Dibenzoyl
* Diphenyl-alpha,beta-diketone
* Diphenylethanedione
* 1,2-Diphenylethanedione
* Diphenylglyoxal
* Ethanedione, diphenyl* Glyoxal, diphenyl* WY-20910
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: Standard Draize test
: Administration into the eye
: Rodent - rabbit
DOSE/DURATION
: 100 mg/24H
REACTION SEVERITY
: Moderate
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,294,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >3 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.11970Volume(issue)/page/year: 15,359,1984
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4886
No. of Facilities: 29 (estimated)
No. of Industries: 2
No. of Occupations: 2
No. of Employees: 72 (estimated)
No. of Female Employees: 44 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
BENZILIC ACID
RTECS NUMBER
: DD2064000
CHEMICAL NAME
: Benzilic acid
CAS REGISTRY NUMBER
: 76-93-7
BEILSTEIN REFERENCE NO. : 0521402
REFERENCE
: 4-10-00-01256 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C14-H12-O3
MOLECULAR WEIGHT
: 228.26
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
* Acide diphenylhydroxyacetique
* Benzeneacetic acid, alpha-hydroxy-alpha-phenyl* Diphenylglycolic acid
* alpha,alpha-Diphenylglycolic acid
* Diphenylhydroxyacetic acid
* Hydroxydiphenylacetic acid
* alpha-Hydroxy-alpha-phenylbenzeneacetic acid
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 116,154,1958
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 116,154,1958
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BENZIMIDAZOLE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
* 3-Azaindole
* Azindole
* Benziminazole
* 1H-Benzimidazole
* o-Benzimidazole
* 1,3-Benzodiazole
:
:
:
:
:
:
:
:
:
:
:
DD5425000
Benzimidazole
51-17-2
0109682
5-23-06-00196 (Beilstein Handbook Reference)
199701
11
C7-H6-N2
118.15
T56 BM DNJ
Agricultural Chemical
Mutagen
V.4-
V.4-
*
*
*
*
*
*
Benzoglyoxaline
Benzoimidazole
BZI
1,3-Diazaindene
N,N'-Methenyl-o-phenylenediamine
NSC 759
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCNSA6 National Academy of Sciences, National Research Council,
Chemical-Biological Coordination Center, Review. (Washington, DC)
Volume(issue)/page/year: 5,22,1953
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 385 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.41898- Volume(issue)/page/year: 95,123,1953
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2910 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 105,486,1952
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 445 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation).
Translation
of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)
1967- Volume(issue)/page/year: 14,130,1980
No.1-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 280 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
29QHAQ "Principles of Medicinal Chemistry," Foye, W.O., et al., eds.,
Philadelphia, Lea & Febiger, 1974 Volume(issue)/page/year: -,246,1974
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 250 ug/plate
REFERENCE :
CHIMAD Chimia. (Postfach 2027, CH-4001 Basel, Switzerland)
1947Volume(issue)/page/year: 27,68,1973
V.1-
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 1 mg/disc
REFERENCE :
APMBAY Applied Microbiology. (Washington, DC) V.1-30, 1953-75. For
publisher information, see AEMIDF. Volume(issue)/page/year: 6,23,1958
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 15 mmol/L/48H
REFERENCE :
ANBCA2 Analytical Biochemistry. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11960- Volume(issue)/page/year: 75,45,1976
TYPE OF TEST
: Phage inhibition capacity
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 1 gm/L
REFERENCE :
ZAPOAK Zeitschrift fuer Allgemeine Mikrobiologie. (Akademie-Verlag GmbH,
Postfach 1233, Berlin DDR-1086 Ger. Dem. Rep.) V.11960Volume(issue)/page/year: 12,583,1972
*** REVIEWS ***
TOXICOLOGY REVIEW
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
32,151,1975
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BENZO(A)FLUORENE
RTECS NUMBER
: DF6382000
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
11H-Benzo(a)fluorene
238-84-6
199710
5
C17-H12
216.29
Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* Benzo(a)fluorene
* 1,2-Benzofluorene
* Chrysofluorene
* alpha-Naphthofluorene
*** HEALTH HAZARD DATA ***
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 50 ug/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
174,247,1986
*** REVIEWS ***
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 32,177,1983
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 32,177,1983
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,56,1987
*** STATUS IN U.S. ***
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
BENZO(A)PYRENE
RTECS NUMBER
CHEMICAL NAME
: DJ4200000
: Benzo(e)pyrene
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
192-97-2
1911334
4-05-00-02689 (Beilstein Handbook Reference)
199710
40
C20-H12
252.32
L D6666 B6 2AB TJ
Tumorigen
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* 1,2-Benzopyrene
* 4,5-Benzopyrene
* 1,2-Benzpyrene
* B(e)P
*** HEALTH HAZARD DATA ***
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 360 mg/kg/43W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Gastrointestinal - tumors
REFERENCE :
VRRAAT Vestnik Rentgenologii i Radiologii. Bulletin of Roentgenology and
Radiology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11920Volume(issue)/page/year: 20,276,1938
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 240 mg/kg/30W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11975- Volume(issue)/page/year:
7,51,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 160 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - facilitates action of known carcinogen
REFERENCE :
AJCAA7 American Journal of Cancer. (New York, NY) V.15-40, 1931-40.
For
publisher information, see CNREA8. Volume(issue)/page/year: 27,474,1936
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 140 mg/kg/37W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - facilitates action of known carcinogen
REFERENCE :
AJCAA7 American Journal of Cancer. (New York, NY) V.15-40, 1931-40.
For
publisher information, see CNREA8. Volume(issue)/page/year: 27,474,1936
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 516 mg/kg/43W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment
Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.11948Volume(issue)/page/year: 12,1079,1959
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 300 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o
Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho,
Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher
information, see CGANE7. Volume(issue)/page/year: 21,97,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 150 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o
Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho,
Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher
information, see CGANE7. Volume(issue)/page/year: 21,97,1981
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 1 ug/plate
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 6(Suppl
2),1,1984
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 100 mg/L
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year:
4,335,1989
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 2 mg/L
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year:
4,335,1989
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Human HeLa cell
DOSE/DURATION
: 1 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
38,2621,1978
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Human Cells - not otherwise specified
DOSE/DURATION
: 12 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
130,127,1984
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 8 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
371,123,1996
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 10 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
368,59,1996
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
: Unscheduled DNA synthesis
: Rodent - rat Liver
: 7900 nmol/L
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
42,3010,1982
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 100 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
192,185,1987
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 625 ug/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
12(Suppl 13),103,1988
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - mouse Embryo
DOSE/DURATION
: 10 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
12,21,1988
TYPE OF TEST
: DNA adduct
ROUTE OF EXPOSURE
: Administration onto the skin
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 192 umol/kg
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 5,231,1984
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - hamster Kidney
DOSE/DURATION
: 25 ug/L
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
7,143,1980
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 10 mg/L
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC)
V.1-60,
1940-78. For publisher information, see JJIND8.
Volume(issue)/page/year:
42,867,1969
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 100 umol/L/4H
REFERENCE :
BBRCA9 Biochemical and Biophysical Research Communications. (Academic
Press, Inc., 1 E. First St., Duluth, MN 55802) V.11959Volume(issue)/page/year: 72,732,1976
TYPE OF TEST
: Sister chromatid exchange
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - hamster
DOSE/DURATION
: 900 mg/kg/24H
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
66,65,1979
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 1 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
53,284,1978
*** REVIEWS ***
IARC Cancer Review:Animal Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 3,137,1973
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 32,225,1983
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 32,225,1983
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,56,1987
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-BALB/c-3T3;
SHE-clonal
assay
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-RLV F344 rat embryo;
E
coli polA with S9
EPA GENETOX PROGRAM 1988, Negative: V79 cell culture-gene mutation; S
cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Inconclusive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Inconclusive: L5178Y cells in vitro-TK test; E
coli polA without S9
EPA GENETOX PROGRAM 1988, Inconclusive: In vivo SCE-nonhuman
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Polynuclear aromatic hydrocarbons by HPLC,
5506; by GC, 5515
BENZO(A)PYRENE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
DJ3675000
Benzo(a)pyrene
50-32-8
199907
370
C20-H12
252.32
L D6 B6666 2AB TJ
Tumorigen
Mutagen
Reproductive Effector
Primary Irritant
SYNONYMS/TRADE NAMES :
* Benzo(d,e,f)chrysene
* 3,4-Benzopirene
* 3,4-Benzopyrene
* 6,7-Benzopyrene
* 3,4-Benzpyren
* Benz(a)pyrene
* 3,4-Benzpyrene
* 3,4-Benz(a)pyrene
* 3,4-Benzypyrene
* BP
* B(a)P
* 3,4-BP
* Coal tar pitch volatiles: benzo(a)pyrene
* RCRA waste number U022
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 14 ug
REACTION SEVERITY
: Mild
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11975- Volume(issue)/page/year:
4,333,1978
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZEKBAI Zeitschrift fuer Krebsforschung. (Berlin, Fed. Rep. Ger.)
V.1-75,
1903-71. For publisher information, see JCROD7.
Volume(issue)/page/year:
69,103,1967
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
23,288,1972
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intrarenal
SPECIES OBSERVED
: Amphibian - frog
DOSE/DURATION
: 9 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
24,1969,1964
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
9 gm/kg/90D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.11981- Volume(issue)/page/year: 30,323,1996
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2250 mg/kg/5W-I
TOXIC EFFECTS :
Blood - changes in spleen
Immunological Including Allergic - decreased immune response
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
148,126,1998
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 400 mg/kg/2W-I
TOXIC EFFECTS :
Immunological Including Allergic - decrease in humoral immune response
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.11981- Volume(issue)/page/year: 3,86,1983
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 15 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Gastrointestinal - tumors
Musculoskeletal - tumors
REFERENCE :
EXPTAX Experimentelle Pathologie (1967-1980). (Jena, Ger. Dem. Rep.)
V.1-18, 1967-80. For publisher information, see EXPADD.
Volume(issue)/page/year: 18,288,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 16 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.11947Volume(issue)/page/year:
12,65,1958
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 455 ug/kg/60D-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11969- Volume(issue)/page/year:
29,159,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 39 mg/kg/6D-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
29,506,1969
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2400 ug/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: DOE/EV/03140-5
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intracerebral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 22 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Brain and Coverings - tumors
Tumorigenic - tumors at site of application
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
29,1927,1969
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intratracheal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1200 ug/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Skin and Appendages - tumors
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 10,1285,1989
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Implant
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 150 ug/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Tumorigenic - tumors at site of application
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 72,733,1984
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 700 mg/kg/75W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Blood - leukemia
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 45(12),14,1980
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 200 ng/m3/6H/13W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 47(7),23,1982
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
(V/O
(V/O
TDLo - Lowest published toxic dose
Administration onto the skin
Rodent - mouse
120 mg/kg
multigenerations
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Reproductive - Tumorigenic effects - transplacental tumorigenesis
REFERENCE :
BEXBAN Bulletin of Experimental Biology and Medicine (English
Translation).
Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY
10013) V.411956- Volume(issue)/page/year: 71,677,1971
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: TDLo - Lowest published toxic dose
: Administration onto the skin
: Rodent - mouse
DOSE/DURATION
: 28500 ug/kg/19W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 9,297,1987
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 25 ng/kg/110W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Skin and Appendages - tumors
Tumorigenic - tumors at site of application
REFERENCE :
ARGEAR Archiv fuer Geschwulstforschung. (VEB Verlag Volk und Gesundheit
Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.11949Volume(issue)/page/year: 50,266,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 10 mg/kg
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York,
Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.11978Volume(issue)/page/year: 4,74,1980
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TDLo - Lowest published toxic dose
Intraperitoneal
Rodent - mouse
300 mg/kg
female 16-18 day(s) after conception
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Reproductive - Tumorigenic effects - transplacental tumorigenesis
Lungs, Thorax, or Respiration - tumors
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 6,569,1980
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TDLo - Lowest published toxic dose
Subcutaneous
Rodent - mouse
300 mg/kg
female 18-19 day(s) after conception
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Reproductive - Specific Developmental Abnormalities - respiratory system
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11975- Volume(issue)/page/year:
55,227,1990
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 9 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 71,309,1983
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TDLo - Lowest published toxic dose
Subcutaneous
Rodent - mouse
480 mg/kg
female 11-15 day(s) after conception
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Reproductive - Tumorigenic effects - transplacental tumorigenesis
Lungs, Thorax, or Respiration - tumors
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.11903/04Volume(issue)/page/year: 135,84,1970
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 10 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC)
V.1-60,
1940-78. For publisher information, see JJIND8.
Volume(issue)/page/year:
1,225,1940
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intratracheal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 200 mg/kg/10W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
PWPSA8 Proceedings of the Western Pharmacology Society. (Univ. of
California Dept. of Pharmacology, Los Angeles, CA 90024) V.11958Volume(issue)/page/year: 22,269,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Implant
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.11947Volume(issue)/page/year:
39,761,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 80 mg/kg/8D-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
BEBMAE Byulleten' Eksperimental'noi Biologii i Meditsiny. Bulletin of
Experimental Biology and Medicine. For English translation, see BEXBAN.
(V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 88(11),592,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Rectal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Blood - leukemia
Gastrointestinal - colon tumors
REFERENCE :
ONCOBS Oncology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland)
V.211967- Volume(issue)/page/year: 37,77,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 819 mg/kg/26W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 65,921,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Implant
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 651 mg/kg/21W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - dyspnea
Tumorigenic - tumors at site of application
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 65,921,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Primate - monkey
DOSE/DURATION
: 40 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Tumorigenic - tumors at site of application
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.11903/04Volume(issue)/page/year: 127,594,1968
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 17 mg/kg/57W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
HSZPAZ Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie. (Walter de
Gruyter, Inc., 200 Saw Mill River Rd., Hawthorne, NY 10532) V.211895/96Volume(issue)/page/year: 236,79,1935
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TDLo - Lowest published toxic dose
Intravenous
Rodent - rabbit
30 mg/kg
female 25 day(s) after conception
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Reproductive - Tumorigenic effects - transplacental tumorigenesis
Peripheral Nerve and Sensation - structural change in nerve or sheath
REFERENCE :
BEXBAN Bulletin of Experimental Biology and Medicine (English
Translation).
Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY
10013) V.411956- Volume(issue)/page/year: 85,369,1978
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intratracheal
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 145 mg/kg/2Y-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - bronchiogenic carcinoma
Blood - leukemia
REFERENCE :
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan)
V.1-75,
1907-84. For publisher information, see JJCREP.
Volume(issue)/page/year:
71,197,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - hamster
DOSE/DURATION
: 420 mg/kg/21W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Gastrointestinal - tumors
Skin and Appendages - tumors
REFERENCE :
ZEKBAI Zeitschrift fuer Krebsforschung. (Berlin, Fed. Rep. Ger.)
V.1-75,
1903-71. For publisher information, see JCROD7.
Volume(issue)/page/year:
65,56,1962
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - hamster
DOSE/DURATION
: 9500 ug/m3/4H/96W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Sense Organs and Special Senses (Olfaction) - tumors
Lungs, Thorax, or Respiration - tumors
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 66,575,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - hamster
DOSE/DURATION
: 4000 ug/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - bronchiogenic carcinoma
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
32,360,1972
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intratracheal
SPECIES OBSERVED
: Rodent - hamster
DOSE/DURATION
: 64 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11975- Volume(issue)/page/year:
3,231,1977
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TDLo - Lowest published toxic dose
Intratracheal
Rodent - hamster
120 mg/kg/17W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11975- Volume(issue)/page/year:
25,271,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Implant
SPECIES OBSERVED
: Rodent - hamster
DOSE/DURATION
: 5 mg/kg/22W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
47,5202,1987
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Implant
SPECIES OBSERVED
: Amphibian - frog
DOSE/DURATION
: 45 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
Switzerland) V.11945- Volume(issue)/page/year: 20,143,1964
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Implant
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 500 ug/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Tumorigenic - tumors at site of application
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11975- Volume(issue)/page/year:
20,97,1983
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 12 mg/kg/20D-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 6,1483,1985
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Intratracheal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 200 mg/kg/15W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Liver - tumors
REFERENCE :
31BYAP "Experimental Lung Cancer: Carcinogenesis and Bioassays,
International Symposium, 1974," Karbe, E., and J.F. Park, eds.,
Springer-Verlag New York, Inc., 1974 Volume(issue)/page/year: -,199,1974
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 26 mg/kg/65W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
AJPAA4 American Journal of Pathology. (Lippincott/Harper, Journal
Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.11925Volume(issue)/page/year: 102,381,1981
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Rectal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 560 mg/kg/14W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Skin and Appendages - tumors
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11975- Volume(issue)/page/year:
20,117,1983
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 8 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
12,657,1952
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Intratracheal
SPECIES OBSERVED
: Rodent - hamster
DOSE/DURATION
: 360 mg/kg/36W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
32,28,1972
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3150 ug/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research.
(Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.11954Volume(issue)/page/year: 21,72,1980
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 18 mg/kg/73W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Skin and Appendages - tumors
Tumorigenic - tumors at site of application
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 38,149,1981
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 12 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan)
V.1-75,
1907-84. For publisher information, see JJCREP.
Volume(issue)/page/year:
62,309,1971
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 40 mg/kg
SEX/DURATION
: female 14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
(e.g., placenta, umbilical cord)
Reproductive - Effects on Embryo or Fetus - other effects to embryo
REFERENCE :
NSAPCC Naunyn-Schmiedeberg's Archives of Pharmacology. (Springer Verlag,
Heidelberger, Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.2721972-
Volume(issue)/page/year: 272,89,1972
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
2 gm/kg
female 28 day(s) pre-mating
female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - stillbirth
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
REFERENCE :
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
Switzerland) V.11945- Volume(issue)/page/year: 20,224,1964
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1344 mg/kg
SEX/DURATION
: female 15 day(s) pre-mating - 5 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - live birth index (measured after
birth)
REFERENCE :
DOESD6 DOE Symposium Series. (NTIS, 5285 Port Royal Rd., Springfield, VA
22161) No.451978- Volume(issue)/page/year: 54,410,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 60 mg/kg
SEX/DURATION
: female 16-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
BNEOBV Biology of the Neonate. (S. Karger Pub., Inc., 79 Fifth Ave., New
York, NY 10003) V.151970- Volume(issue)/page/year: 38,291,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 150 mg/kg
SEX/DURATION
: female 6-8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 42,195,1986
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
:
:
:
:
TDLo - Lowest published toxic dose
Intramuscular
Rodent - rat
2100 ug/kg
SEX/DURATION
: female 15-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
JDPHDH Journal of Developmental Physiology. (Oxford University Press,
Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1979Volume(issue)/page/year: 19,67,1993
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 100 mg/kg
SEX/DURATION
: female 16 day(s) pre-mating - 5 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Maternal Effects - oogenesis
REFERENCE :
DOESD6 DOE Symposium Series. (NTIS, 5285 Port Royal Rd., Springfield, VA
22161) No.451978- Volume(issue)/page/year: 54,410,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 1280 mg/kg
SEX/DURATION
: female 16 day(s) pre-mating - 5 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - germ cell effects (in offspring)
REFERENCE :
DOESD6 DOE Symposium Series. (NTIS, 5285 Port Royal Rd., Springfield, VA
22161) No.451978- Volume(issue)/page/year: 54,410,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 100 mg/kg
SEX/DURATION
: female 7-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - delayed effects
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 19,37A,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 100 mg/kg
SEX/DURATION
: multigenerations
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter;
measured
before birth)
Reproductive - Fertility - female fertility index (e.g. # females
pregnant
per # sperm positive females; # females pregnant per # females mated)
Reproductive - Fertility - male fertility index (e.g. # males
impregnating
females per # males exposed to fertile nonpregnant females)
REFERENCE :
BIREBV Biology of Reproduction.
(Soc. for the Study of Reproduction, 309
Clark St., Champaign, IL 61820)
24,183,1981
V.1-
W.
1969-
Volume(issue)/page/year:
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 75 mg/kg
SEX/DURATION
: female 12-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 32,29A,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 100 mg/kg
SEX/DURATION
: female 7-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
REFERENCE :
BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309
W.
Clark St., Champaign, IL 61820) V.11969- Volume(issue)/page/year:
24,183,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 50 mg/kg
SEX/DURATION
: female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - oogenesis
REFERENCE :
PPHAD4 Pediatric Pharmacology. (New York, NY) V.1-5, 1980-86. For
publisher information, see DPTHDL. Volume(issue)/page/year: 1,143,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 1500 mg/kg
SEX/DURATION
: male 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
1,712,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 300 mg/kg
SEX/DURATION
: female 16-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - immune and
reticuloendothelial system
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 6,569,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 200 mg/kg
SEX/DURATION
: female 7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - skin and skin
appendages
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 20,365,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 150 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - stillbirth
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: CONF-771017
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 250 mg/kg
SEX/DURATION
: female 13-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - cytological changes
(including
somatic cell genetic material)
Reproductive - Specific Developmental Abnormalities - blood and lymphatic
systems (including spleen and marrow)
Reproductive - Specific Developmental Abnormalities - immune and
reticuloendothelial system
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005)
Volume(issue)/page/year: 42,259,1994
V.1-
1975/76-
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 160 mg/kg
SEX/DURATION
: female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - live birth index (measured after
birth)
Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
PPHAD4 Pediatric Pharmacology. (New York, NY) V.1-5, 1980-86. For
publisher information, see DPTHDL. Volume(issue)/page/year: 1,85,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 12 gm/kg
SEX/DURATION
: multigeneration
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - respiratory system
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11975- Volume(issue)/page/year:
55,227,1990
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 40 ug/kg
SEX/DURATION
: female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - oogenesis
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
76,18,1984
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 10 mg/kg
SEX/DURATION
: male 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 8,929,1981
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 2 ug/plate
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 5,505,1984
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 312 ng/plate
REFERENCE :
RCOCB8 Research Communications in Chemical Pathology and Pharmacology.
(PJD
Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.11970Volume(issue)/page/year: 44,131,1984
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 1 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
192,239,1987
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 147 gm/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
109,183,1983
TYPE OF TEST
: Phage inhibition capacity
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 3900 pmol/plate
REFERENCE :
PPTCBY Proceedings of the International Symposium of the Princess
Takamatsu
Cancer Research Fund. (Japan Scientific Soc. Press, 6-2-10 Hongo,
Bunkyo-ku,
Tokyo 113, Japan) 1st1971- Volume(issue)/page/year: 9,337,1979
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 1 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
60,395,1979
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 700 pmol/tube
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United
States
of America. (National Academy of Sciences, Printing & Pub. Office, 2101
Constitution Ave., Washington, DC 20418) V.11915Volume(issue)/page/year: 79,5971,1982
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 200 nmol/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
135,87,1984
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 70 ug/well
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
46,53,1977
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 500 mg/L
REFERENCE :
BBACAQ Biochimica et Biophysica Acta. (Elsevier Science Pub. B.V., POB
211,
1000 AE Amsterdam, Netherlands) V.11947- Volume(issue)/page/year:
103,275,1965
TYPE OF TEST
: Phage inhibition capacity
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 400 ng/plate
REFERENCE :
CSHCAL Cold Spring Harbor Conferences on Cell Proliferation. (Cold
Spring
Harbor, NY) V.1-10, 1974-83. Volume(issue)/page/year: 4,1451,1977
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Bacillus subtilis
DOSE/DURATION
: 5 gm/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
42,19,1977
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Bacteria - Bacillus subtilis
DOSE/DURATION
: 200 ug/disc
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
1,175,1981
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 3 umol/L
REFERENCE :
PNCCA2 Proceedings, National Cancer Conference. (Philadelphia, PA)
V.1-7,
1949-72. For publisher information, see CANCAR.
Volume(issue)/page/year:
5,39,1965
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 1 mg/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 2,417,1981
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 200 ug/L
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United
States
of America. (National Academy of Sciences, Printing & Pub. Office, 2101
Constitution Ave., Washington, DC 20418) V.11915Volume(issue)/page/year: 74,1378,1977
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 100 ug/L
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United
States
of America. (National Academy of Sciences, Printing & Pub. Office, 2101
Constitution Ave., Washington, DC 20418) V.11915Volume(issue)/page/year: 74,1378,1977
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 11 ng/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11969- Volume(issue)/page/year:
39,205,1982
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 100 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
368,235,1996
TYPE OF TEST
: Specific locus test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 250 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
234,71,1990
TYPE OF TEST
ROUTE OF EXPOSURE
: DNA repair
: Oral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 100 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
290,175,1993
TYPE OF TEST
: DNA adduct
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 1 mmol/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
23,171,1994
TYPE OF TEST
: Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE
: Parenteral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 5 mmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
33,302,1973
TYPE OF TEST
: Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 100 umol/L
REFERENCE :
BIZNAT Biologisches Zentralblatt. (VEB Georg Thieme, Postfach 946,
Leipzig
DDR-7010, Ger. Dem. Rep.) V.11881- Volume(issue)/page/year:
102,271,1983
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 1 gm/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
1,414,1981
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 50 mg/L
REFERENCE :
CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co.,
USA,
1255 Howard St., San Francisco, CA 94103) V.61958Volume(issue)/page/year: 33,1576,1985
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
: Gene conversion and mitotic recombination
: Yeast - Saccharomyces cerevisiae
: 10 ug/plate
PMRSDJ Progress in Mutation Research.
(Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017)
Volume(issue)/page/year:
1,456,1981
V.1-
1981-
TYPE OF TEST
: Sex chromosome loss and nondisjunction
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 150 mg/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
1,468,1981
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Multiple routes
TEST SYSTEM
: Non-mammalian species
DOSE/DURATION
: 1000 ppb
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
390,33,1997
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Multiple routes
TEST SYSTEM
: Non-mammalian species
DOSE/DURATION
: 10 ppb/8D (Continuous)
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 8,41,1986
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Fish - not otherwise specified
DOSE/DURATION
: 10 mg/kg
REFERENCE :
CYTBAI Cytobios. (Faculty Press, 88 Regent St., Cambridge, UK)
1969Volume(issue)/page/year: 47,147,1986
V.1-
TYPE OF TEST
: Specific locus test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Insect - not otherwise specified
DOSE/DURATION
: 500 ppm
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
268,155,1992
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Multiple routes
TEST SYSTEM
: Non-mammalian species
DOSE/DURATION
: 60 ppb
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
292,83,1993
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Non-mammalian species
DOSE/DURATION
: 1700 nmol/L
REFERENCE :
GANMAX Gann Monograph. (Tokyo, Japan) No.1-10, 1966-71. For publisher
information, see GMCRDC. Volume(issue)/page/year: 6,49,1968
TYPE OF TEST
: DNA adduct
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Fish - not otherwise specified
DOSE/DURATION
: 20 mg/kg
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11975- Volume(issue)/page/year:
49,81,1990
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Fish - salmon Testis
DOSE/DURATION
: 5 ug/1H (Continuous)
REFERENCE :
BIJOAK Biochemical Journal. (Biochemical Soc. Book Depot, POB 32,
Commerce
Way, Colchester, Essex CO2 8HP, UK) V.11906Volume(issue)/page/year:
110,159,1968
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Fish - salmon Cells - not otherwise specified
DOSE/DURATION
: 80 umol/L
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 23,51,1978
TYPE OF TEST
: DNA damage
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Fish - not otherwise specified
DOSE/DURATION
: 125 gm/kg
REFERENCE :
STEVA8 Science of the Total Environment. (Elsevier Science Pub. B.V.,
POB
211, 1000 AE Amsterdam, Netherlands) V.11972Volume(issue)/page/year:
32,13,1983
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Fish - not otherwise specified Liver
DOSE/DURATION
: 10 umol/L
REFERENCE :
NCIMAV National Cancer Institute, Monograph. (U.S. Government Printing
Office, Supt. of Documents, Washington, DC 20402) No.11959Volume(issue)/page/year: 65,163,1984
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
: Unscheduled DNA synthesis
: Fish - not otherwise specified Liver
: 20 nmol/L
HKXUDL Huanjing Kexue Xuebao. Environmental Sciences Journal. (China
International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China)
V.11981-
Volume(issue)/page/year: 4,368,1984
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Fish - not otherwise specified Liver
DOSE/DURATION
: 1 umol/L
REFERENCE :
AECTCV Archives of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
070944) V.11973- Volume(issue)/page/year: 14,555,1985
TYPE OF TEST
TEST SYSTEM
otherwise
: Unscheduled DNA synthesis
: Fish - not otherwise specified Cells - not
specified
DOSE/DURATION
: 10 umol/L
REFERENCE :
CBPCEE Comparative Biochemistry and Physiology, C: Pharmacology,
Toxicology
and Endocrinology. (Elsevier Science, 660 White Plains Rd., Tarrytown, NY
10591) V.741983- Volume(issue)/page/year: 86,399,1987
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Administration onto the skin
TEST SYSTEM
: Fish - not otherwise specified
DOSE/DURATION
: 100 ng/L
REFERENCE :
EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1
E.
First St., Duluth, MN 55802) V.11977- Volume(issue)/page/year:
5,261,1981
TYPE OF TEST
TEST SYSTEM
otherwise
: Cytogenetic analysis
: Fish - not otherwise specified Cells - not
specified
DOSE/DURATION
: 100 ug/L/48H
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 4,181,1982
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Multiple routes
TEST SYSTEM
: Non-mammalian species
DOSE/DURATION
: 10 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
319,223,1993
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Fish - not otherwise specified Fibroblast
DOSE/DURATION
: 5 mg/L
REFERENCE :
AECTCV Archives of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
070944)
V.1-
1973-
Volume(issue)/page/year: 10,663,1981
TYPE OF TEST
: Micronucleus test
TEST SYSTEM
: Human Cells - not otherwise specified
DOSE/DURATION
: 10 mg/L
REFERENCE :
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House,
Fairview
Park, Elmsford, NY 10523) V.11987- Volume(issue)/page/year:
5,515,1991
TYPE OF TEST
: Micronucleus test
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 50 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
291,93,1993
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 4 mg/L
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 63,309,1979
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Human Liver
DOSE/DURATION
: 100 nmol/L
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research.
(Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.11954Volume(issue)/page/year: 25,117,1984
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Human Cells - not otherwise specified
DOSE/DURATION
: 10 mg/L
REFERENCE :
ITCSAF In Vitro. (Rockville, MD) V.1-20, 1965-85. For publisher
information, see ICDBEO. Volume(issue)/page/year: 17,719,1981
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Human Fibroblast
DOSE/DURATION
: 3200 ug/L
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11975- Volume(issue)/page/year:
13,119,1981
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 1 umol/L/72H
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
49,6503,1989
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Human Fibroblast
DOSE/DURATION
: 10 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
390,179,1997
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Human Fibroblast
DOSE/DURATION
: 10 mg/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
38,1638,1978
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Human Cells - not otherwise specified
DOSE/DURATION
: 1500 nmol/L
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss,
Inc.,
41 E. 11th St., New York, NY 10003) V.11980Volume(issue)/page/year:
1,3,1980
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Human HeLa cell
DOSE/DURATION
: 1500 nmol/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
17,20,1991
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Human Leukocyte
DOSE/DURATION
: 500 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
346,49,1995
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Human Cells - not otherwise specified
DOSE/DURATION
: 400 nmol/L
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United
States
of America. (National Academy of Sciences, Printing & Pub. Office, 2101
Constitution Ave., Washington, DC 20418) V.11915Volume(issue)/page/year: 78,6251,1981
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
: Unscheduled DNA synthesis
: Human Cells - not otherwise specified
: 1 umol/L
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House,
Fairview
Park, Elmsford, NY 10523) V.11987- Volume(issue)/page/year:
5,377,1991
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Human HeLa cell
DOSE/DURATION
: 1 mmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
38,2621,1978
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Human Lung
DOSE/DURATION
: 1 umol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 3,195,1982
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Human Liver
DOSE/DURATION
: 1 umol/L
REFERENCE :
BANRDU Banbury Report. (Cold Spring Harbor Laboratory, POB 100, Cold
Spring
Harbor, NY 11724) V.11979- Volume(issue)/page/year: 13,101,1982
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human HeLa cell
DOSE/DURATION
: 1500 nmol/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
17,20,1991
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Human Cells - not otherwise specified
DOSE/DURATION
: 4 umol/L
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11975- Volume(issue)/page/year:
18,11,1983
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Human Cells - not otherwise specified
DOSE/DURATION
: 10 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
122,377,1983
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
: Unscheduled DNA synthesis
: Human Cells - not otherwise specified
: 3 mg/L
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
140,43,1984
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Human Cells - not otherwise specified
DOSE/DURATION
: 5 umol/L
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
79,28,1985
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human Fibroblast
DOSE/DURATION
: 1 mg/L
REFERENCE :
NEOLA4 Neoplasma. (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland)
V.41957- Volume(issue)/page/year: 33,699,1986
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Human Mammary gland
DOSE/DURATION
: 10 umol/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
20,148,1992
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human Fibroblast
DOSE/DURATION
: 40 umol/L/24H
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
46,297,1977
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human Leukocyte
DOSE/DURATION
: 1 mg/L
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.11947Volume(issue)/page/year:
30,103,1974
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 2400 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
113,239,1983
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Human Leukocyte
DOSE/DURATION
: 50 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1346,49,1995
1964-
Volume(issue)/page/year:
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 1 umol/L/72H
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
49,6503,1989
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Human Fibroblast
DOSE/DURATION
: 1 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
58,317,1978
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Human Liver
DOSE/DURATION
: 1 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
117,47,1983
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Human Cells - not otherwise specified
DOSE/DURATION
: 100 nmol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 1,765,1980
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Human Fibroblast
DOSE/DURATION
: 100 nmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
40,4070,1980
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 3 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
128,221,1984
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 1200 nmol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 4,304,1982
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 800 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
182,309,1987
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 125 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
278,165,1992
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - rat Cells - not otherwise specified
DOSE/DURATION
: 1 mg/L
REFERENCE :
NEOLA4 Neoplasma. (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland)
V.41957- Volume(issue)/page/year: 30,303,1983
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 100 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
43,5087,1983
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - rat Cells - not otherwise specified
DOSE/DURATION
: 4 ug/tube
REFERENCE :
BLFSBY Basic Life Sciences. (Plenum Pub. Corp., 223 Spring St., New
York,
NY 10003) V.11973- Volume(issue)/page/year: 24,331,1983
TYPE OF TEST
: Morphological transformation
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 200 mg/kg
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
40,1157,1980
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Rodent - rat Lung
DOSE/DURATION
: 2 umol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 3,267,1982
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - rat Embryo
DOSE/DURATION
: 15400 ug/L
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 67,1303,1981
TYPE OF TEST
: DNA adduct
ROUTE OF EXPOSURE
: Intravenous
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 140 ug/kg
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
38,4640,1978
TYPE OF TEST
: DNA adduct
ROUTE OF EXPOSURE
: Administration onto the skin
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 800 nmol/kg
REFERENCE :
IJCNAW International Journal of Cancer. (International Union Against
Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.11966Volume(issue)/page/year: 28,387,1981
TYPE OF TEST
: DNA adduct
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 40 mg/kg
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 5,231,1984
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 80 umol/L
REFERENCE :
JBCHA3 Journal of Biological Chemistry. (428 E. Preston St., Baltimore,
MD
21202) V.11905- Volume(issue)/page/year: 252,6424,1977
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - rat Fibroblast
DOSE/DURATION
: 1500 umol/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11969- Volume(issue)/page/year:
18,337,1977
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Rodent - rat Cells - not otherwise specified
DOSE/DURATION
: 1500 nmol/L
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss,
Inc.,
41 E. 11th St., New York, NY 10003) V.11980-
Volume(issue)/page/year:
1,3,1980
TYPE OF TEST
: DNA damage
ROUTE OF EXPOSURE
: Intratracheal
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 50 mg/kg
REFERENCE :
CBINA8 Chemico-Biological Interactions.
Ireland
Ltd., POB 85, Limerick, Ireland) V.136,129,1981
(Elsevier Scientific Pub.
1969-
Volume(issue)/page/year:
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Rodent - rat Cells - not otherwise specified
DOSE/DURATION
: 1 umol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 4,297,1983
TYPE OF TEST
: Unscheduled DNA synthesis
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 240 mg/kg/8D (Continuous)
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
218,13,1989
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - rat Cells - not otherwise specified
DOSE/DURATION
: 31 umol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 3,203,1982
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 5 umol/L
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11975- Volume(issue)/page/year:
6,207,1979
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - rat Cells - not otherwise specified
DOSE/DURATION
: 100 mmol/L
REFERENCE :
SHKKAN Shika Kiso Igakkai Zasshi. Journal of the Japanese Association
for
Basic Dentistry. (Shika Kiso Igakkai, Hanayama Bldg., 1-44-2 Komagome,
Toshima-ku, Tokyo 170, Japan) V.11959- Volume(issue)/page/year:
22,300,1980
TYPE OF TEST
ROUTE OF EXPOSURE
: DNA damage
: Oral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 62500 ug/kg
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 10,393,1989
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Rodent - rat Embryo
DOSE/DURATION
: 500 ug/L
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research.
(Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.11954Volume(issue)/page/year: 25,86,1984
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 10 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
45,337,1985
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - rat Cells - not otherwise specified
DOSE/DURATION
: 1 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
241,361,1990
TYPE OF TEST
: DNA inhibition
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 40 mg/kg
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11958Volume(issue)/page/year:
34,755,1985
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Rodent - rat Cells - not otherwise specified
DOSE/DURATION
: 5 mg/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 15,661,1994
TYPE OF TEST
: Body fluid assay
TEST SYSTEM
: Rodent - rat Bacteria - Salmonella typhimurium
DOSE/DURATION
: 10 mg/kg
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 1,155,1979
TYPE OF TEST
TEST SYSTEM
: Body fluid assay
: Rodent - rat Ovary
DOSE/DURATION
: 2 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
143,263,1985
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 3 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
419,91,1998
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Intravenous
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 50 mg/kg
REFERENCE :
GANNA2 Gann. Japanese Journal of Cancer Research.
V.1-75,
1907-84. For publisher information, see JJCREP.
Volume(issue)/page/year:
64,637,1973
(Tokyo, Japan)
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 800 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
182,309,1987
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Unreported
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 423 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
113,239,1983
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - rat Cells - not otherwise specified
DOSE/DURATION
: 100 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
169,141,1986
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 1600 pmol/L
REFERENCE :
ECEBDI Experimental Cell Biology. (S. Karger Pub., Inc., 79 Fifth Ave.,
New
York, NY 10003) V.441976- Volume(issue)/page/year: 52,355,1984
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - rat Cells - not otherwise specified
DOSE/DURATION
: 500 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
93,409,1982
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - rat Ascites tumor
DOSE/DURATION
: 1 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
122,47,1983
TYPE OF TEST
: Sister chromatid exchange
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 25 mg/kg
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 10,1041,1989
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - rat Cells - not otherwise specified
DOSE/DURATION
: 18850 nmol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 5,33,1983
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - rat Mammary gland
DOSE/DURATION
: 1 mg/L
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 70,777,1983
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 1 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
130,53,1984
TYPE OF TEST
: Micronucleus test
TEST SYSTEM
: Rodent - mouse Fibroblast
DOSE/DURATION
: 250 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
279,217,1992
TYPE OF TEST
ROUTE OF EXPOSURE
TEST SYSTEM
: Micronucleus test
: Oral
: Rodent - mouse
DOSE/DURATION
: 40 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
234,179,1990
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Administration onto the skin
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 20 ug/kg
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
17,163,1991
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 30 mg/kg
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
1,698,1981
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 250 ug/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
12(Suppl 13),103,1988
TYPE OF TEST
: Specific locus test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 80 mg/kg
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
38,99,1977
TYPE OF TEST
: Specific locus test
ROUTE OF EXPOSURE
: Parenteral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 100 mg/kg
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
38,75,1977
TYPE OF TEST
ROUTE OF EXPOSURE
TEST SYSTEM
: Morphological transformation
: Oral
: Rodent - mouse
DOSE/DURATION
: 100 mg/kg/8D (Intermittent)
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
49,1236,1989
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 500 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
203,155,1988
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - mouse Cells - not otherwise specified
DOSE/DURATION
: 100 ug/L
REFERENCE :
IJCNAW International Journal of Cancer. (International Union Against
Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.11966Volume(issue)/page/year: 4,166,1969
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - mouse Embryo
DOSE/DURATION
: 100 ug/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
5,659,1985
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - mouse Fibroblast
DOSE/DURATION
: 500 ug/L
REFERENCE :
AETODY Advances in Modern Environmental Toxicology.
P.O. Box 252, Princeton Junction, NJ 08550) V.1Volume(issue)/page/year: 1,133,1980
(Senate Press, Inc.,
1980-
TYPE OF TEST
: Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE
: Administration onto the skin
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 4 mg/kg
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.11895- Volume(issue)/page/year:
199,778,1978
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Rodent - mouse Liver
DOSE/DURATION
: 6 umol/L
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 62,947,1979
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - mouse Fibroblast
DOSE/DURATION
: 3 mg/L
REFERENCE :
COINAV Colloques Internationaux du Centre National de la Recherche
Scientifique. (Kluwer Academic Pub., POB 358, Accord Stn., Hingham, MA
02018) V.11946- Volume(issue)/page/year: 256,389,1977
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Rodent - mouse Embryo
DOSE/DURATION
: 1200 nmol/L
REFERENCE :
IJCNAW International Journal of Cancer. (International Union Against
Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.11966Volume(issue)/page/year: 4,813,1969
TYPE OF TEST
: DNA adduct
ROUTE OF EXPOSURE
: Administration onto the skin
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 40 umol/kg
REFERENCE :
IJCNAW International Journal of Cancer. (International Union Against
Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.11966Volume(issue)/page/year: 23,201,1979
TYPE OF TEST
: Unscheduled DNA synthesis
ROUTE OF EXPOSURE
: Administration onto the skin
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 8 mg/kg
REFERENCE :
PHMGBN Pharmacology: International Journal of Experimental and Clinical
Pharmacology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.11968- Volume(issue)/page/year: 18,281,1979
TYPE OF TEST
: DNA adduct
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 240 mg/kg
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
42,1199,1982
TYPE OF TEST
: Unscheduled DNA synthesis
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 12 mg/kg
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
44,1547,1984
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - mouse Fibroblast
DOSE/DURATION
: 7 umol/L
REFERENCE :
JOUOD4 Journal of UOEH (University of Occupational and Environmental
Health). (Univ. of Occupational and Environmental Health, 1-1 Iseigaoka,
Yahata-nishi-ku, Kitakyushu 807, Japan) V.1Volume(issue)/page/year: 5,147,1983
1979-
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - mouse Cells - not otherwise specified
DOSE/DURATION
: 100 umol/L
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 65,1321,1980
TYPE OF TEST
: DNA inhibition
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 100 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
46,305,1977
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - mouse Liver
DOSE/DURATION
: 1 umol/L
REFERENCE :
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia,
Warner-Lambert
Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106)
V.6(3/4)1978- Volume(issue)/page/year: 12,119,1984
TYPE OF TEST
: Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE
: Administration onto the skin
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 200 mg/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11969- Volume(issue)/page/year:
4,155,1971/1972
TYPE OF TEST
: Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 50 mg/kg
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
19,259,1992
TYPE OF TEST
: Body fluid assay
TEST SYSTEM
: Rodent - mouse Bacteria - Salmonella typhimurium
DOSE/DURATION
: 100 mg/kg
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
38,4478,1978
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 50 mg/kg
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
19,259,1992
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 25 mg/kg
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis.
Inc.,
41 E. 11th St., New York, NY 10003) V.11980Volume(issue)/page/year:
3,321,1983
(Alan R. Liss,
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - mouse Leukocyte
DOSE/DURATION
: 100 ug/L/17H (Continuous)
REFERENCE :
IJCNAW International Journal of Cancer. (International Union Against
Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.11966Volume(issue)/page/year: 9,435,1972
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - mouse Fibroblast
DOSE/DURATION
: 5 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
42,1866,1982
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 2500 ug/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 8(Suppl
6),24,1986
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - mouse Lung
DOSE/DURATION
: 25 mg/kg
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.11903/04Volume(issue)/page/year: 158,269,1978
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
ENMUDM Environmental
: Sister chromatid exchange
: Rodent - mouse Embryo
: 1 umol/L
Mutagenesis.
(New York, NY)
V.1-9, 1979-87.
For
publisher information, see EMMUEG.
Volume(issue)/page/year: 2,245,1980
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - mouse Fibroblast
DOSE/DURATION
: 100 nmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
42,1866,1982
TYPE OF TEST
: Sister chromatid exchange
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 20 mg/kg
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 10,1041,1989
TYPE OF TEST
: Sister chromatid exchange
ROUTE OF EXPOSURE
: Intravenous
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 100 mg/kg
REFERENCE :
JJMCAQ Japanese Journal of Medical Science and Biology. (National
Institute
of Health, 2-chome, Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.51952Volume(issue)/page/year: 38,207,1985
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - mouse Bone marrow
DOSE/DURATION
: 30 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
224,465,1989
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - mouse Cells - not otherwise specified
DOSE/DURATION
: 30 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
224,465,1989
TYPE OF TEST
: Dominant lethal test
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 750 mg/kg
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ
08736)
V.11869- Volume(issue)/page/year: 219,385,1968
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
: Mutation in mammalian somatic cells
: Rodent - mouse Lymphocyte
: 4500 ug/L
PMRSDJ Progress in Mutation Research.
(Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017)
Volume(issue)/page/year:
1,580,1981
V.1-
1981-
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - mouse Embryo
DOSE/DURATION
: 3 umol/L
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United
States
of America. (National Academy of Sciences, Printing & Pub. Office, 2101
Constitution Ave., Washington, DC 20418) V.11915Volume(issue)/page/year: 76,930,1979
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - mouse Fibroblast
DOSE/DURATION
: 200 nmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
42,1866,1982
TYPE OF TEST
: Host-mediated assay
TEST SYSTEM
: Rodent - mouse Bacteria - Escherichia coli
DOSE/DURATION
: 50464 ug/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
241,83,1990
TYPE OF TEST
: Sperm Morphology
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 100 mg/kg/5D
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United
States
of America. (National Academy of Sciences, Printing & Pub. Office, 2101
Constitution Ave., Washington, DC 20418) V.11915Volume(issue)/page/year: 72,4425,1975
TYPE OF TEST
: Sperm Morphology
ROUTE OF EXPOSURE
: Parenteral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 500 mg/kg
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
38,75,1977
TYPE OF TEST
ROUTE OF EXPOSURE
TEST SYSTEM
DOSE/DURATION
REFERENCE :
ENMUDM Environmental
:
:
:
:
Sperm Morphology
Unreported
Rodent - mouse
200 mg/kg
Mutagenesis.
(New York, NY)
V.1-9, 1979-87.
For
publisher information, see EMMUEG.
Volume(issue)/page/year: 4,318,1982
TYPE OF TEST
: Micronucleus test
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 100 ug/L
REFERENCE :
CCLCDY Zhonghua Zhongliu Zazhi. Chinese Journal of Oncology. (China
International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China)
V.11978- Volume(issue)/page/year: 8,90,1986
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 4 umol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 10,419,1989
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 1 mg/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 4,354,1982
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 25 nmol/plate
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
39,2660,1979
TYPE OF TEST
: Specific locus test
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 5 mg/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
1,594,1981
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Rodent - hamster Cells - not otherwise specified
DOSE/DURATION
: 1 umol/L
REFERENCE :
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House,
Fairview
Park, Elmsford, NY 10523) V.11987- Volume(issue)/page/year:
5,511,1991
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - hamster Cells - not otherwise specified
DOSE/DURATION
: 1200 nmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
35,2413,1975
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 10 ug/L
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year: 1000(Sp
Iss
1),18,1980
TYPE OF TEST
: Morphological transformation
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - hamster
DOSE/DURATION
: 500 mg/kg
REFERENCE :
ARPAAQ Archives of Pathology. (Chicago, IL) V.5(3)-50(3), 1928-50;
V.70-99, 1960-75. For publisher information, see APLMAS.
Volume(issue)/page/year: 95,380,1973
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 400 ug/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11969- Volume(issue)/page/year:
13,105,1976
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - hamster Kidney
DOSE/DURATION
: 80 ug/L
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.11947Volume(issue)/page/year:
37,873,1978
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - hamster Fibroblast
DOSE/DURATION
: 1 mg/L
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ
08736)
V.11869- Volume(issue)/page/year: 264,360,1976
TYPE OF TEST
: Morphological transformation
ROUTE OF EXPOSURE
: Parenteral
TEST SYSTEM
: Rodent - hamster
DOSE/DURATION
: 1 mg/L
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United
States
of America. (National Academy of Sciences, Printing & Pub. Office, 2101
Constitution Ave., Washington, DC 20418) V.11915Volume(issue)/page/year: 56,672,1966
TYPE OF TEST
TEST SYSTEM
: DNA damage
: Rodent - hamster Lung
DOSE/DURATION
: 30 umol/L/2H
REFERENCE :
BBRCA9 Biochemical and Biophysical Research Communications. (Academic
Press, Inc., 1 E. First St., Duluth, MN 55802) V.11959Volume(issue)/page/year: 72,732,1976
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 100 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
77,259,1980
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 500 ug/L
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research.
(Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.11954Volume(issue)/page/year: 25,86,1984
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Rodent - hamster Cells - not otherwise specified
DOSE/DURATION
: 800 nmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
33,2837,1973
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 300 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
129,111,1984
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 1 mg/L
REFERENCE :
BICHAW Biochemistry. (American Chemical Soc., Distribution Office Dept.
223, POB 57136, West End Stn., Washington, DC 20037) V.11962Volume(issue)/page/year: 17,1597,1978
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - hamster Cells - not otherwise specified
DOSE/DURATION
: 100 nmol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 3,1283,1982
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
: DNA adduct
: Rodent - hamster Cells - not otherwise specified
: 1 umol/L
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
43,4723,1983
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - hamster Liver
DOSE/DURATION
: 10 umol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 5,1,1983
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - hamster Cells - not otherwise specified
DOSE/DURATION
: 100 ug/L
REFERENCE :
EVSRBT Environmental Science Research. (Plenum Pub. Corp., 233 Spring
St.,
New York, NY 10013) V.11972- Volume(issue)/page/year: 27,277,1983
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 6 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
230,111,1990
TYPE OF TEST
: Phage inhibition capacity
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 60 ug/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 6,474,1984
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - hamster Cells - not otherwise specified
DOSE/DURATION
: 150 umol/L
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11975- Volume(issue)/page/year:
53,163,1990
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - hamster Fibroblast
DOSE/DURATION
: 10 umol/L
REFERENCE :
LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview
Park,
Elmsford, NY 10523) V.1-8, 1962-69; V.141974Volume(issue)/page/year:
48,1255,1991
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Rodent - hamster Cells - not otherwise specified
DOSE/DURATION
: 5 mg/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980-
Volume(issue)/page/year: 15,661,1994
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 3970 nmol/L
REFERENCE :
MOTOEX Molecular Toxicology. (Taylor & Francis, Inc., 242 Cherry St.,
Philadelphia, PA USA 19106) V.11987- Volume(issue)/page/year:
1,217,1987
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Inhalation
TEST SYSTEM
: Rodent - hamster
DOSE/DURATION
: 100 ug/L/5D (Intermittent)
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.11981- Volume(issue)/page/year: 1,139,1981
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - hamster
DOSE/DURATION
: 200 mg/kg
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
2,277,1978
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 100 mg/L
REFERENCE :
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York,
Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.11978Volume(issue)/page/year: 4,41,1980
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Fibroblast
DOSE/DURATION
: 1 mg/L
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.11947Volume(issue)/page/year:
30,103,1974
TYPE OF TEST
: Sister chromatid exchange
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - hamster
DOSE/DURATION
: 900 mg/kg/24H
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
66,65,1979
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 5610 nmol/L
REFERENCE :
MOTOEX Molecular Toxicology. (Taylor & Francis, Inc., 242 Cherry St.,
Philadelphia, PA USA 19106) V.11,217,1987
1987-
Volume(issue)/page/year:
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 10 ng/L
REFERENCE :
CHYCDW Zhonghua Yufangyixue Zazhi. Chinese Journal of Preventive
Medicine.
(China International Book Trading Corp., POB 2820, Beijing, Peop. Rep.
China) Beginning history not known. Volume(issue)/page/year:
17,221,1983
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 1 ug/L
REFERENCE :
JCINAO Journal of Clinical Investigation. (Rockefeller Univ. Press, 1230
York Ave., New York, NY 10021) V.11924- Volume(issue)/page/year:
64,1245,1979
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Fibroblast
DOSE/DURATION
: 500 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
93,409,1982
TYPE OF TEST
: Sister chromatid exchange
ROUTE OF EXPOSURE
: Inhalation
TEST SYSTEM
: Rodent - hamster
DOSE/DURATION
: 100 ug/L/5D (Intermittent)
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: DE83-007112
TYPE OF TEST
ROUTE OF EXPOSURE
TEST SYSTEM
DOSE/DURATION
REFERENCE :
EXPEAM Experientia.
Switzerland) V.1-
:
:
:
:
Sister chromatid exchange
Unreported
Rodent - hamster
25 mg/kg
(Birkhaeuser Verlag, POB 133, CH-4010 Basel,
1945- Volume(issue)/page/year: 33,25,1977
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Cells - not otherwise specified
DOSE/DURATION
: 9900 nmol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 6,1627,1985
TYPE OF TEST
: Sex chromosome loss and nondisjunction
TEST SYSTEM
: Rodent - hamster Liver
DOSE/DURATION
: 1 mg/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017)
Volume(issue)/page/year:
5,397,1985
V.1-
1981-
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Liver
DOSE/DURATION
: 110 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
207,69,1988
TYPE OF TEST
: Mutation in mammalian somatic cells
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - hamster
DOSE/DURATION
: 200 mg/kg
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
2,277,1978
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 1 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
113,499,1983
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - hamster Fibroblast
DOSE/DURATION
: 1 mg/L
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ
08736)
V.11869- Volume(issue)/page/year: 264,360,1976
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 500 ug/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
44,1445,1984
TYPE OF TEST
: Sperm Morphology
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - hamster
DOSE/DURATION
: 25 mg/kg/5D
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 8,929,1981
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
: Cytogenetic analysis
: Rodent - hamster Ovary
: 1 mmol/L
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
111,209,1983
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - guinea pig Cells - not otherwise
specified
DOSE/DURATION
: 10 mg/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
35,1035,1975
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Primate - monkey Lung
DOSE/DURATION
: 25 umol/L
REFERENCE :
50NNAZ "Polynuclear Aromatic Hydrocarbons, International Symposium, 7th,
1982," Cooke, M., and A.J. Dennis, eds., Columbus, OH, Battelle Press,
1983
Volume(issue)/page/year: 7,845,1983
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Primate - monkey Cells - not otherwise specified
DOSE/DURATION
: 1 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
43,4723,1983
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Primate - monkey Cells - not otherwise specified
DOSE/DURATION
: 25 umol/L
REFERENCE :
50NNAZ "Polynuclear Aromatic Hydrocarbons, International Symposium, 7th,
1982," Cooke, M., and A.J. Dennis, eds., Columbus, OH, Battelle Press,
1983
Volume(issue)/page/year: 7,845,1983
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Primate - monkey Liver
DOSE/DURATION
: 10 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
206,91,1988
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Primate - monkey Kidney
DOSE/DURATION
: 1 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
45,3626,1985
TYPE OF TEST
ROUTE OF EXPOSURE
TEST SYSTEM
DOSE/DURATION
:
:
:
:
Micronucleus test
Multiple routes
Amphibian - frog
60 ppb
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year:
4,12,1989
TYPE OF TEST
: DNA adduct
ROUTE OF EXPOSURE
: Intravenous
TEST SYSTEM
: Rodent - rabbit
DOSE/DURATION
: 1 mg/kg
REFERENCE :
CBINA8 Chemico-Biological Interactions.
Ireland
Ltd., POB 85, Limerick, Ireland) V.151,151,1984
(Elsevier Scientific Pub.
1969-
Volume(issue)/page/year:
TYPE OF TEST
: DNA damage
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Amphibian - frog
DOSE/DURATION
: 125 gm/kg
REFERENCE :
STEVA8 Science of the Total Environment. (Elsevier Science Pub. B.V.,
POB
211, 1000 AE Amsterdam, Netherlands) V.11972Volume(issue)/page/year:
32,13,1983
TYPE OF TEST
: DNA adduct
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - rabbit
DOSE/DURATION
: 11 mg/kg
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 3,1405,1982
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Mammal - species unspecified Lymphocyte
DOSE/DURATION
: 30 umol/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11969- Volume(issue)/page/year:
47,87,1983
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Mammal - species unspecified Kidney
DOSE/DURATION
: 1 mmol/L
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 6,333,1980
TYPE OF TEST
: Unscheduled DNA synthesis
ROUTE OF EXPOSURE
: Administration onto the skin
TEST SYSTEM
: Rodent - rabbit
DOSE/DURATION
: 100 ug/L
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research.
(Waverly
Press, 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 21,94,1980
V.1-
1954-
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Mammal - dog Cells - not otherwise specified
DOSE/DURATION
: 1 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
43,4723,1983
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Mammal - dog Lung
DOSE/DURATION
: 1 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
43,4723,1983
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Parenteral
TEST SYSTEM
: Bird - chicken
DOSE/DURATION
: 31 ug/kg
REFERENCE :
47JMAE "Cytogenetic Assays of Environmental Mutagens," Hsu, T.C., ed.,
Totowa, NJ, Allanheld, Osmun & Co., 1982 Volume(issue)/page/year:
-,137,1982
TYPE OF TEST
: Sister chromatid exchange
ROUTE OF EXPOSURE
: Administration onto the skin
TEST SYSTEM
: Rodent - rabbit
DOSE/DURATION
: 30 ug/L
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research.
(Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.11954Volume(issue)/page/year: 21,94,1980
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - rabbit Lymphocyte
DOSE/DURATION
: 10 umol/L/30M
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
58,321,1978
TYPE OF TEST
: Sister chromatid exchange
ROUTE OF EXPOSURE
: Parenteral
TEST SYSTEM
: Bird - chicken
DOSE/DURATION
: 31 ug/kg
REFERENCE :
47JMAE "Cytogenetic Assays of Environmental Mutagens," Hsu, T.C., ed.,
Totowa, NJ, Allanheld, Osmun & Co., 1982 Volume(issue)/page/year:
-,137,1982
TYPE OF TEST
ROUTE OF EXPOSURE
TEST SYSTEM
DOSE/DURATION
:
:
:
:
Sister chromatid exchange
Multiple routes
Amphibian - frog
10 mg/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 8(Suppl
6),30,1986
*** REVIEWS ***
ACGIH TLV-Suspected human carcinogen, NO TWA
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 3,91,1973
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 32,211,1983
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 32,211,1983
IARC Cancer Review:Group 2A
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,56,1987
TOXICOLOGY REVIEW
32XPAD "Teratology," Berry, C.L., and D.E. Poswillo, eds., New York,
Springer, 1975 Volume(issue)/page/year: -,49,1975
TOXICOLOGY REVIEW
ACRSAJ Advances in Cancer Research. (Academic Press, Inc., 465 S.
Lincoln
Dr., Troy, MO 63379) V.11953- Volume(issue)/page/year: 7,475,1963
TOXICOLOGY REVIEW
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
39,257,1977
TOXICOLOGY REVIEW
ZHPMAT Zentralblatt fuer Bakteriologie, Parasitenkunde,
Infektionskrankheiten und Hygiene, Abteilung 1: Originale, Reihe B:
Hygiene,
Krankenhaushygiene, Betriebshygiene, Praeventive Medizin. (Stuttgart,
Fed.
Rep. Ger.) V.155-169, 1971-1979. For publisher information, see ZAOMDC.
Volume(issue)/page/year: 166,144,1978
TOXICOLOGY REVIEW
BNYMAM Bulletin of the New York Academy of Medicine.
(New York Academy
of
Medicine, 2 E. 103rd St., New York, NY 10029)
Volume(issue)/page/year: 54,413,1978
Ser 2: V.1-
1925-
TOXICOLOGY REVIEW
PEXTAR Progress in Experimental Tumor Research. (S. Karger AG, Postfach
CH-4009 Basel, Switzerland) V.11960- Volume(issue)/page/year:
5,157,1964
TOXICOLOGY REVIEW
85CVA2 "Oncology 1970, Proceedings of the Tenth International Cancer
Congress," Chicago, Year Book Medical Pub., 1971
Volume(issue)/page/year:
5,257,1970
TOXICOLOGY REVIEW
85DHAX "Medical and Biologic Effects of Environmental Pollutants Series,"
Washington, DC, National Academy of Sciences, 1972-77
Volume(issue)/page/year: Pc,4,1972
TOXICOLOGY REVIEW
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: CONF-691001
TOXICOLOGY REVIEW
BLFSBY Basic Life Sciences. (Plenum Pub. Corp., 223 Spring St., New
York,
NY 10003) V.11973- Volume(issue)/page/year: 24,129,1983
TOXICOLOGY REVIEW
PVTMA3 Preventive Medicine. (Academic Press, Inc., 1 E. First St.,
Duluth,
MN 55802) V.11972- Volume(issue)/page/year: 9,622,1980
*** U.S. STANDARDS AND REGULATIONS ***
OSHA PEL (Gen Indu):8H TWA 0.2 mg/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 0.2 mg/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 0.2 mg/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 0.2 mg/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA;Carcinogen JAN 1993
OEL-BELGIUM;Carcinogen JAN 1993
OEL-FINLAND:TWA 0.01 mg/m3;Skin;Carcinogen JAN 1993
OEL-GERMANY;Carcinogen JAN 1993
OEL-RUSSIA:STEL 0.00015 mg/m3;Carcinogen JAN 1993
OEL-SWEDEN:TWA 0.005 mg/m3;STEL 0.03 mg/m3;Skin JAN 1993
OEL-POLAND: TWA 0.003 mg/m3, JAN1999
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - T0450
No. of Facilities: 11 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 32 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - T0450
No. of Facilities: 75 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 896 (estimated)
No. of Female Employees: 299 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Body fluid assay;
Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/F344 rat;
SHE-focus
assay
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-mouse embryo
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-mouse prostate
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE;
Host-mediated
assay
EPA GENETOX PROGRAM 1988, Positive: L5178Y cells in vitro-TK test;
Mammalian
micronucleus
EPA GENETOX PROGRAM 1988, Positive: Mouse spot test; E coli polA with S9
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: In vitro SCE-human lymphocytes; In
vitro
SCE-human
EPA GENETOX PROGRAM 1988, Positive: Sperm morphology-mouse; D
melanogaster
Sex-linked lethal
EPA GENETOX PROGRAM 1988, Positive: In vitro UDS in rat liver; V79 cell
culture-gene mutation
EPA GENETOX PROGRAM 1988, Positive/dose response: Cell
transform.-BALB/c-3T3; SHE-clonal assay
EPA GENETOX PROGRAM 1988, Positive/dose response: Cell
transform.-C3H/10T1/2
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro SCE-nonhuman;
In
vivo SCE-nonhuman
EPA GENETOX PROGRAM 1988, Negative: D melanogaster-nondisjunction
EPA GENETOX PROGRAM 1988, Negative: Rodent heritable translocation; Mouse
specific locus
EPA GENETOX PROGRAM 1988, Negative: UDS in mouse germ cells; S
cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9; In vitro
UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Positive: CHO gene mutation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Polynuclear aromatic hydrocarbons by HPLC,
5506; by GC, 5515
NTP 8th Annual Report on Carcinogens, 1998:Reasonably Anticipated to be
Human Carcinogen
OSHA ANALYTICAL METHOD #ID-58
BENZO(G,H,I)PERYLENE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
DI6200500
Benzo(ghi)perylene
191-24-2
199710
11
C22-H12
276.34
Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* 1,12-Benzoperylene
* 1,12-Benzperylene
*** HEALTH HAZARD DATA ***
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 2 ug/plate/48H
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 17,141,1979
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 80 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
371,123,1996
TYPE OF TEST
: DNA damage
ROUTE OF EXPOSURE
: Administration onto the skin
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 40 umol/kg
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 14,127,1993
*** REVIEWS ***
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.1-
1972-
Volume(issue)/page/year: 32,195,1983
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 32,195,1983
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,56,1987
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Polynuclear aromatic hydrocarbons by HPLC,
5506; by GC, 5515
BENZO(L)PHENANTHRENE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
YK2925000
Triphenylene
217-59-4
199710
9
C18-H12
228.30
Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* Benzo(l)phenanthrene
* 9,10-Benzophenanthrene
* 9,10-Benzphenanthrene
* 1,2,3,4-Dibenznaphthalene
* Isochrysene
*** HEALTH HAZARD DATA ***
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 44 nmol/plate
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980-
Volume(issue)/page/year: 8,773,1987
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 30 umol/L
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United
States
of America. (National Academy of Sciences, Printing & Pub. Office, 2101
Constitution Ave., Washington, DC 20418) V.11915Volume(issue)/page/year: 85,3513,1988
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 20 umol/L
REFERENCE :
DTESD7 Developments in Toxicology and Environtal Science. (Elsevier
Science, New York, NY) V.1-15, 1977-87. Discontinued
Volume(issue)/page/year: 10,277,1982
*** REVIEWS ***
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 32,447,1983
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 32,447,1983
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,56,1987
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - T1252
No. of Facilities: 11 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 32 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
BENZOFLUORANTHENE (K-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
DF6350000
Benzo(k)fluoranthene
207-08-9
1873745
4-05-00-02686 (Beilstein Handbook Reference)
199809
15
C20-H12
252.32
L E6 C6566 1A TJ
Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* 8,9-Benzofluoranthene
* 11,12-Benzofluoranthene
* 11,12-Benzo(k)fluoranthene
* 2,3,1',8'-Binaphthylene
* Dibenzo(b,jk)fluorene
*** HEALTH HAZARD DATA ***
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Implant
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Tumorigenic - tumors at site of application
REFERENCE :
50NNAZ "Polynuclear Aromatic Hydrocarbons, International Symposium, 7th,
1982," Cooke, M., and A.J. Dennis, eds., Columbus, OH, Battelle Press,
1983
Volume(issue)/page/year: 7,571,1983
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2820 mg/kg/47W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
Tumorigenic - tumors at site of application
REFERENCE :
CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment
Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.11948Volume(issue)/page/year: 12,1194,1959
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
TDLo - Lowest published toxic dose
Subcutaneous
Rodent - mouse
72 mg/kg/9W-I
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
AICCA6 Acta Unio Internationalis Contra Cancrum. (Louvain, Belgium)
V.1-20,
1936-64. For publisher information, see IJCNAW. Volume(issue)/page/year:
19,490,1963
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 10 ug/plate
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
40,4528,1980
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 120 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
371,123,1996
*** REVIEWS ***
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 32,163,1983
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 32,163,1983
IARC Cancer Review:Group 2B
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,56,1987
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - E0464
No. of Facilities: 142 (estimated)
No. of Industries: 3
No. of Occupations: 3
No. of Employees: 2283 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Polynuclear aromatic hydrocarbons by HPLC,
5506; by GC, 5515
NTP 8th Annual Report on Carcinogens, 1998:Reasonably Anticipated to be
Human Carcinogen
BENZOFLUORENE (2,3-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
DF6383500
11H-Benzo(b)fluorene
243-17-4
199710
6
C17-H12
216.29
Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* 2,3-Benzofluorene
*** HEALTH HAZARD DATA ***
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 15 ug/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
174,247,1986
*** REVIEWS ***
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 32,183,1983
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 32,183,1983
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,56,1987
*** STATUS IN U.S. ***
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
BENZOFURAN (2,3-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
DF6423800
Benzofuran
271-89-6
0107704
5-17-02-00003 (Beilstein Handbook Reference)
199904
19
C8-H6-O
118.14
T56 BOJ
Tumorigen
Drug
Mutagen
SYNONYMS/TRADE NAMES :
* Benzo(b)furan
* Benzofuran
* 2,3-Benzofuran
* Benzofurfuran
* Coumarone
* Cumarone
* NCI-C56166
* 1-Oxindene
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique.
(Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France)
V.91974- Volume(issue)/page/year: 12,383,1977
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 7 gm/kg/14D-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-370,1989
(Research
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 16250 mg/kg/13W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
Kidney, Ureter, Bladder - changes in both tubules and glomeruli
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-370,1989
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 32500 mg/kg/13W-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-370,1989
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 437 mg/kg/14D-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-370,1989
(Research
(Research
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 61800 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-370,1989
(Research
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 30900 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Gastrointestinal - tumors
Liver - tumors
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-370,1989
(Research
** MUTATION DATA **
TYPE OF TEST
: Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 100 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
343,157,1995
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 100 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
11,91,1988
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 199 mg/L
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-370,1989
(Research
*** REVIEWS ***
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 63,431,1995
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 63,431,1995
IARC Cancer Review:Group 2B
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 63,431,1995
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M3271
No. of Facilities: 40 (estimated)
No. of Industries: 2
No. of Occupations: 2
No. of Employees: 111 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NTP Carcinogenesis Studies (gavage);clear evidence:mouse
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-370,1989
NTP Carcinogenesis Studies (gavage);some evidence:rat
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-370,1989
BENZOHYDROXAMIC ACID
RTECS NUMBER
: DF9650000
CHEMICAL NAME
: Benzohydroxamic acid
CAS REGISTRY NUMBER
: 495-18-1
LAST UPDATED
: 199709
DATA ITEMS CITED
: 5
MOLECULAR FORMULA
: C7-H7-N-O2
MOLECULAR WEIGHT
: 137.15
WISWESSER LINE NOTATION : QMVR
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Benzamide, N-hydroxy* Benzohydroxamate
* Benzoylhydroxamic acid
* N-Hydroxybenzamide
* Phenylhydroxamic acid
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
(Research
(Research
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCNSA6 National Academy of Sciences, National Research Council,
Chemical-Biological Coordination Center, Review. (Washington, DC)
Volume(issue)/page/year: 5,26,1953
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 2500 nmol/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
135,139,1984
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 333 ug/plate
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
19(Suppl 21),2,1992
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BENZOIC ACID
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
DG0875000
Benzoic acid
65-85-0
199904
28
C7-H6-O2
122.13
QVR
Agricultural Chemical
Mutagen
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* Acide benzoique
* Acido benzoico
* Benzenecarboxylic acid
* Benzeneformic acid
* Benzenemethanoic acid
*
*
*
*
*
*
*
*
*
*
*
*
*
*
Benzoate
Benzoesaeure
Carboxybenzene
Dracylic acid
E 210
HA 1 (acid)
Kyselina benzoova
Phenylcarboxylic acid
Phenylformic acid
Retarder BA
Retardex
Salvo liquid
Salvo powder
Tenn-Plas
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Human
DOSE/DURATION
: 22 mg/3D (Intermittent)
REACTION SEVERITY
: Moderate
REFERENCE :
85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976,"
Drill,
V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977
Volume(issue)/page/year: -,127,1977
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810
Frontage Rd., Northbrook, IL 60062) Volume(issue)/page/year: 28-4/1973
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg
REACTION SEVERITY
: Severe
REFERENCE :
BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810
Frontage Rd., Northbrook, IL 60062) Volume(issue)/page/year: 28-4/1973
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Human
DOSE/DURATION
: 6 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea
Skin and Appendages - dermatitis, allergic (after systemic exposure)
REFERENCE :
JOALAS Journal of Allergy. (St. Louis, MO) V.1-47, 1929-71. For
publisher
information, see JACIBY.
Volume(issue)/page/year: 16,195,1945
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 17,715,1979
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IPSTB3 International Polymer Science and Technology. (Rapra Technology
Ltd., Shawbury, Shrewsbury, Shropshire SY4 4NR, UK)
Volume(issue)/page/year:
3,93,1976
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >26 mg/m3/1H
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Behavioral - somnolence (general depressed activity)
REFERENCE :
BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810
Frontage Rd., Northbrook, IL 60062) Volume(issue)/page/year: 28-4/1973
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale
Farmaceutica,
Via Ausonio 12, 20123 Milan, Italy) V.331894Volume(issue)/page/year:
112,53,1973
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APYPAY Acta Physiologica Polonica. (Karger-Libri, POB CH-4009, Warszawa,
Switzerland) V.1-41, 1950-90. Volume(issue)/page/year: 12,173,1961
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1940 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - respiratory depression
Gastrointestinal - other changes
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.11970Volume(issue)/page/year: 15,359,1984
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1460 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.11849Volume(issue)/page/year: 160,1097,1966
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders
Co.,
1956-59 Volume(issue)/page/year: 5,23,1959
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810
Frontage Rd., Northbrook, IL 60062) Volume(issue)/page/year: 28-4/1973
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders
Co.,
1956-59 Volume(issue)/page/year: 5,23,1959
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MMWOAU Muenchener Medicinische Wochenschrift. (Munich, Fed. Rep. Ger.)
V.33-115, 1886-1973. Volume(issue)/page/year: 77,13,1930
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 1400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders
Co.,
1956-59 Volume(issue)/page/year: 5,23,1959
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Amphibian - frog
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders
Co.,
1956-59 Volume(issue)/page/year: 5,23,1959
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1200 mg/m3/4W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - fibrosis (interstitial)
Related to Chronic Data - death
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0539172
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 10 mmol/L
REFERENCE :
ZBPIA9 Zentralblatt fuer Bakteriologie, Parasitenkunde,
Infektionskrankheiten und Hygiene, Abteilung II. Naturwissenschaftliche:
Allgemeine, Landwirtschaftliche und Technische Mikrobiologie. (Jena, Ger.
Dem. Rep.) V.107-132, 1952-77. Volume(issue)/page/year: 112,226,1959
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
: DNA inhibition
: Human Lymphocyte
: 5 mmol/L
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United
States
of America. (National Academy of Sciences, Printing & Pub. Office, 2101
Constitution Ave., Washington, DC 20418) V.11915Volume(issue)/page/year: 79,1171,1982
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 10210
No. of Facilities: 2798 (estimated)
No. of Industries: 35
No. of Occupations: 52
No. of Employees: 77830 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 10210
No. of Facilities: 9179 (estimated)
No. of Industries: 85
No. of Occupations: 81
No. of Employees: 155176 (estimated)
No. of Female Employees: 55139 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; S
cerevisiae-homozygosis
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
BENZOIC ACID METHYL ESTER
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
WISWESSER LINE NOTATION :
COMPOUND DESCRIPTOR
:
DH3850000
Benzoic acid, methyl ester
93-58-3
199806
11
C8-H8-O2
136.16
1OVR
Natural Product
SYNONYMS/TRADE NAMES :
* Essence of niobe
* Methyl benzenecarboxylate
* Methylester kyseliny benzoove
* Niobe oil
* Oil of niobe
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1177 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
Gastrointestinal - hypermotility, diarrhea
Skin and Appendages - hair
REFERENCE :
FAVUAI Fiziologicheski Aktivnye Veshchestva. Physiologically Active
Substances. (Izdatel'stvo Naukova Dumka, Kiev, USSR) No.11966Volume(issue)/page/year: 18,69,1986
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3330 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - excitement
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 2,327,1964
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 10 gm/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - muscle weakness
Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 84,358,1945
V.1-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2170 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
Skin and Appendages - hair
REFERENCE :
1909/10-
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 84,358,1945
1909/10-
&
V.1-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 4100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 12,937,1974
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 17400 mg/kg/60D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in bladder weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 49(11),85,1984
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M1650
No. of Facilities: 61 (estimated)
No. of Industries: 3
No. of Occupations: 6
No. of Employees: 1002 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M1650
No. of Facilities: 4188 (estimated)
No. of Industries: 51
No. of Occupations: 60
No. of Employees: 73641 (estimated)
No. of Female Employees: 25030 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
BENZOIC ACID SODIUM
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
DH6650000
Benzoic acid, sodium salt
532-32-1
199710
30
C7-H5-O2.Na
144.11
QVR &-NAAgricultural Chemical
Drug
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Antimol
* Benzoan sodny
* Benzoate of soda
* Benzoate sodium
* Benzoesaeure (na-salz)
* Sobenate
* Sodium benzoate
* Sodium benzoic acid
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4070 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 30,63,1948
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 28(1),45,1963
TYPE OF TEST
: LD50 - Lethal dose, 50
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1714 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical
Edition. (Washington, DC) V.29-49, 1940-60.
(V/O
percent kill
threshold
Association, Scientific
For publisher information,
see
JPMSAE.
Volume(issue)/page/year: 31,253,1942
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1600 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 51(1),75,1986
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1440 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MECHAN Medicinal Chemistry, A Series of Reviews. (New York, NY) V.1-6,
1951-63. Discontinued. Volume(issue)/page/year: 6,290,1963
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2306 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 117,307,1956
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 53A,34,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 53A,34,1974
TYPE OF TEST
ROUTE OF EXPOSURE
: LD50 - Lethal dose, 50 percent kill
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57,
1948-77. Discontinued. Volume(issue)/page/year: 53A,34,1974
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 1400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1313,1935
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 28(1),45,1963
(V/O
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Amphibian - frog
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1313,1935
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 27370 mg/kg/10D-C
TOXIC EFFECTS :
Liver - changes in liver weight
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Metabolism (Intermediary) - other proteins
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
69,171,1993
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: TDLo - Lowest published toxic dose
: Oral
: Rodent - rat
DOSE/DURATION
: 84 gm/kg/28D-C
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Kidney, Ureter, Bladder - other changes
Related to Chronic Data - death
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 144,120,1963
V.4-
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 137 gm/kg/13W-C
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
TRENAF Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho. Annual Report of
Tokyo
Metropolitan Research Laboratory of Public Health. (Tokyo-toritsu Eisei
Kenkyusho, 24-1, 3-chome, Hyakunin-cho, Shin-juku-ku, Tokyo 160, Japan)
V.11949/50- Volume(issue)/page/year: 42,285,1991
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 45 gm/kg/10D-C
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
69,171,1993
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 44 gm/kg
SEX/DURATION
: female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - homeostasis
Reproductive - Specific Developmental Abnormalities - eye/ear
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic
Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu,
Setagaya-ku, Tokyo 158, Japan) V.11886- Volume(issue)/page/year:
(96),47,1978
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
:
SPECIES OBSERVED
:
DOSE
:
SEX/DURATION
:
TOXIC EFFECTS :
Reproductive - Effects
Oral
Rodent - rat
44 gm/kg
female 1-22 day(s) after conception
on Newborn - viability index (e.g., # alive at day
4
per # born alive)
REFERENCE :
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic
Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu,
Setagaya-ku, Tokyo 158, Japan) V.11886- Volume(issue)/page/year:
(96),47,1978
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 3 gm/kg
SEX/DURATION
: female 12-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
19,373,1971
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 300 mg/kg
SEX/DURATION
: female 12-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
19,373,1971
** MUTATION DATA **
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 10 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
241,109,1990
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 1 gm/L
REFERENCE :
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York,
Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.11978Volume(issue)/page/year: 4,41,1980
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Fibroblast
DOSE/DURATION
: 2 gm/L/48H
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
48,337,1977
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 80214
No. of Facilities: 13289 (estimated)
No. of Industries: 84
No. of Occupations: 69
No. of Employees: 92390 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X1192
No. of Facilities: 31 (estimated)
No. of Industries: 2
No. of Occupations: 2
No. of Employees: 430 (estimated)
No. of Female Employees: 288 (estimated)
NOES - National Occupational
NOES Hazard Code - 80214
No. of Facilities: 20457
No. of Industries: 143
No. of Occupations: 125
No. of Employees: 533161
No. of Female Employees:
Exposure Survey (1983)
(estimated)
(estimated)
199915 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: TRP reversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
BENZOIC ACID SULFIMIDE (ORTHO-)
RTECS NUMBER
: DE4200000
CHEMICAL NAME
: 1,2-Benzisothiazolin-3-one, 1,1-dioxide
CAS REGISTRY NUMBER
: 81-07-2
LAST UPDATED
: 199701
DATA ITEMS CITED
: 52
MOLECULAR FORMULA
: C7-H5-N-O3-S
MOLECULAR WEIGHT
: 183.19
WISWESSER LINE NOTATION : T56 BSWMVJ
COMPOUND DESCRIPTOR
: Tumorigen
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Anhydro-o-sulfaminebenzoic acid
* 3-Benzisothiazolinone 1,1-dioxide
* 1,2-Benzisothiazol-3(2H)-one 1,1-dioxide
* o-Benzoic sulfimide
* Benzoic sulphimide
* o-Benzoic sulphimide
* o-Benzosulfimide
* Benzosulphimide
* o-Benzosulphimide
* Benzo-2-sulphimide
* o-Benzoyl sulfimide
* o-Benzoyl sulphimide
* 1,2-Dihydro-2-ketobenzisosulfonazole
* 1,2-Dihydro-2-ketobenzisosulphonazole
* 2,3-Dihydro-3-oxobenzisosulfonazole
* 2,3-Dihydro-3-oxobenzisosulphonazole
* Garantose
* Glucid
* Gluside
* Hermesetas
* 3-Hydroxybenzisothiazole-S,S-dioxide
* Insoluble saccharin
* Kandiset
* RCRA waste number U202
* Sacarina
* Saccharimide
* Saccharin
* Saccharina
* Saccharin acid
* Saccharine
* Saccharin insoluble
* Saccharinol
* Saccharinose
* Saccharol
* Sacharin
* Sucre edulcor
* Sucrette
* o-Sulfobenzimide
* o-Sulfobenzoic acid imide
* 2-Sulphobenzoic imide
* Zaharina
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 17 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EXPEAM Experientia.
Switzerland) V.1-
(Birkhaeuser Verlag, POB 133, CH-4010 Basel,
1945- Volume(issue)/page/year: 35,1364,1979
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 365 gm/kg/1Y-I
TOXIC EFFECTS :
Blood - normocytic anemia
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
36,81,1987
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2008 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific
Edition. (Washington, DC) V.29-49, 1940-60. For publisher information,
see
JPMSAE. Volume(issue)/page/year: 40,583,1951
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 548 gm/kg/1Y-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Endocrine - thyroid tumors
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications &
Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1Volume(issue)/page/year: 24,197,1986
1963-
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 9600 mg/kg/10W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.11947Volume(issue)/page/year:
10,363,1956
TYPE OF TEST
ROUTE OF EXPOSURE
: TDLo - Lowest published toxic dose
: Implant
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 80 mg/kg
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Kidney, Ureter, Bladder - tumors
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.11947Volume(issue)/page/year:
11,212,1957
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 16800 mg/kg
SEX/DURATION
: multigenerations
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora
lutea)
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.11973- Volume(issue)/page/year: 8,285,1977
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - mouse
101 gm/kg
female 1-21 day(s) after conception
lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
alive at weaning per # alive at day 4)
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
REFERENCE :
DBTEAD Diabete. (Le Raincy, France) V.1-22, 1953-74. Discontinued.
Volume(issue)/page/year: 17,103,1969
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 252 gm/kg
SEX/DURATION
: multigenerations
TOXIC EFFECTS :
Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
alive at weaning per # alive at day 4)
REFERENCE :
DBTEAD Diabete. (Le Raincy, France) V.1-22, 1953-74. Discontinued.
Volume(issue)/page/year: 17,103,1969
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - mouse
155 mg/kg
female 7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
IIZAAX Iwate Igaku Zasshi. Journal of the Iwate Medical Association.
(c/o
Iwate Ika Daigaku, 19-1 Uchimaru, Morioka, 020, Japan) V.11947Volume(issue)/page/year: 16,330,1964
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 2 mg/plate
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.11895- Volume(issue)/page/year:
198,944,1977
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 4 gm/L
REFERENCE :
JEGPAY Journal of the Egyptian Public Health Association. (Egyptian
Public
Health Assoc., Shousha Bldg., Bloc. A, 31 Sharia 26 July, App. 116,
Cairo,
Egypt) V.11926- Volume(issue)/page/year: 54,154,1979
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 200 mg/L
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ
08736)
V.11869- Volume(issue)/page/year: 294,263,1981
TYPE OF TEST
: Sex chromosome loss and nondisjunction
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 300 umol/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
11,497,1988
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human HeLa cell
DOSE/DURATION
: 140 mmol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 13,2389,1992
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 1000 ppm
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.11895- Volume(issue)/page/year:
200,543,1978
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - rat Cells - not otherwise specified
DOSE/DURATION
: 5 mmol/L
REFERENCE :
ICDBEO In Vitro Cellular and Developmental Biology. (Tissue Culture
Assoc.,
19110 Montgomery Village Ave., Suite 300, Gaithersburg, MD 20879) V.211985- Volume(issue)/page/year: 21,402,1985
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 3 mmol/L
REFERENCE :
SinJF# Personal Communication from J.F. Sina, Merck Institute for
Therapeutic Research, West Point, PA 19486, Oct. 26, 1982
Volume(issue)/page/year: 26OCT1982
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 100 pmol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 5,1547,1984
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - rat Cells - not otherwise specified
DOSE/DURATION
: 1 mmol/L
REFERENCE :
ICDBEO In Vitro Cellular and Developmental Biology. (Tissue Culture
Assoc.,
19110 Montgomery Village Ave., Suite 300, Gaithersburg, MD 20879) V.211985- Volume(issue)/page/year: 21,402,1985
TYPE OF TEST
: DNA inhibition
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 40500 mg/kg(60D
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11975- Volume(issue)/page/year:
13,259,1981
TYPE OF TEST
: Specific locus test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 750 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
103,49,1982
TYPE OF TEST
ROUTE OF EXPOSURE
TEST SYSTEM
DOSE/DURATION
:
:
:
:
DNA damage
Intraperitoneal
Rodent - mouse
100 mg/kg
REFERENCE :
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York,
Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.11978Volume(issue)/page/year: 5,355,1982
TYPE OF TEST
: Body fluid assay
TEST SYSTEM
: Rodent - mouse Bacteria - Salmonella typhimurium
DOSE/DURATION
: 2500 mg/kg
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.11895- Volume(issue)/page/year:
198,944,1977
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 168 gm/kg/24W (Continuous)
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications &
Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1Volume(issue)/page/year: 25,124,1987
1963-
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Fibroblast
DOSE/DURATION
: 30 mg/L
REFERENCE :
HDSKEK Hiroshima Daigaku Sogo Kagakubu Kiyo, 4: Kiso, Kankyo Kagaku
Kenkyu.
Bulletin of the Faculty of Integrated Arts and Sciences, Hiroshima
University, Series 4: Fundamental and Environmental Sciences. (1-1-89
Higashisenda-machi, Naka-ku, Hiroshima 730, Japan) V.61980Volume(issue)/page/year: 10,63,1985
TYPE OF TEST
ROUTE OF EXPOSURE
TEST SYSTEM
DOSE/DURATION
REFERENCE :
EXPEAM Experientia.
Switzerland) V.1-
:
:
:
:
Sister chromatid exchange
Oral
Rodent - hamster
7500 mg/kg
(Birkhaeuser Verlag, POB 133, CH-4010 Basel,
1945- Volume(issue)/page/year: 35,1364,1979
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 1000 ppm
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.11895- Volume(issue)/page/year:
200,543,1978
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 100 mg/L
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.11947Volume(issue)/page/year:
45,769,1982
*** REVIEWS ***
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 22,111,1980
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 22,111,1980
IARC Cancer Review:Group 2B
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,334,1987
TOXICOLOGY REVIEW
PWPSA8 Proceedings of the Western Pharmacology Society. (Univ. of
California Dept. of Pharmacology, Los Angeles, CA 90024) V.11958Volume(issue)/page/year: 18,306,1975
TOXICOLOGY REVIEW
TOANDB Toxicology Annual. (New York, NY)
Volume(issue)/page/year: -,71,1974
1974/75-79.
Discontinued.
TOXICOLOGY REVIEW
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
32,81,1975
TOXICOLOGY REVIEW
WMWOA4 Wiener Medizinische Wochenschrift.
(Brueder Hollinek, Gallgasse
40,
A-1130 Vienna, Austria) V.1121,515,1971
1851-
Volume(issue)/page/year:
TOXICOLOGY REVIEW
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 25,173,1978
TOXICOLOGY REVIEW
BLFSBY Basic Life Sciences. (Plenum Pub. Corp., 223 Spring St., New
York,
NY 10003) V.11973- Volume(issue)/page/year: 24,129,1983
TOXICOLOGY REVIEW
NUCADQ Nutrition and Cancer.
Phildelphia, PA 19103) V.1-
(Franklin Institute Press, POB 2266,
1978- Volume(issue)/page/year: 3,109,1981
TOXICOLOGY REVIEW
FAATDF Fundamental and Applied Toxicology.
(Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 4,674,1984
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 80507
No. of Facilities: 1556 (estimated)
No. of Industries: 37
No. of Occupations: 36
No. of Employees: 44968 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 80507
No. of Facilities: 7348 (estimated)
No. of Industries: 107
No. of Occupations: 73
No. of Employees: 225094 (estimated)
No. of Female Employees: 97727 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Body fluid assay; Rodent dominant
lethal
EPA GENETOX PROGRAM 1988, Positive: Host-mediated assay; S cerevisiae
gene
conversion
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-aneuploidy; S
cerevisiae-reversion
EPA GENETOX PROGRAM 1988, Weakly Positive: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Negative: SHE-clonal assay; Cell
transform.-C3H/10T1/2
EPA GENETOX PROGRAM 1988, Negative: N crassa-aneuploidy; E coli polA
without
S9
EPA GENETOX PROGRAM 1988, Negative: E coli polA with S9
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-reciprocal
translocation
EPA GENETOX PROGRAM 1988, Inconclusive: L5178Y cells in vitro-TK test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BENZOIC HYDRAZIDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
: DH1575000
: Benzoic acid, hydrazide
: 613-94-5
LAST UPDATED
: 199701
DATA ITEMS CITED
: 8
MOLECULAR FORMULA
: C7-H8-N2-O
MOLECULAR WEIGHT
: 136.17
WISWESSER LINE NOTATION : ZMR XVQ
COMPOUND DESCRIPTOR
: Tumorigen
SYNONYMS/TRADE NAMES :
* Hydrazine, benzoyl* Benzhydrazide
* Benzohydrazide
* Benzohydrazine
* Benzoic hydrazide
* Benzoyl hydrazide
* Hydrazid kyseliny benzoove
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - somnolence (general depressed activity)
Behavioral - tremor
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK)
V.1-33, 1946-68. For publisher information, see BJPCBM.
Volume(issue)/page/year: 11,417,1956
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 122 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 122,110,1958
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 122 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai,
2-12-15
Shibuya, Shibuya-ku, Tokyo 150, Japan) No.11881Volume(issue)/page/year: 81,1225,1961
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LDLo - Lowest published lethal dose
: Subcutaneous
: Rodent - rabbit
DOSE/DURATION
: 102 mg/kg
TOXIC EFFECTS :
Endocrine - hypoglycemia
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 30,87,1927
V.1-
1909/10-
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 15 gm/kg/77W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Blood - lymphoma, including Hodgkin's disease
REFERENCE :
EJCAAH European Journal of Cancer. (Oxford, UK) V.1-17(6), 1965-1981.
For
publisher information, see EJCODS. Volume(issue)/page/year: 8,341,1972
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 13 gm/kg/30W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
34ZRA9 "Proceedings of the Quadrennial Conference on Cancer, 3rd, 1965,"
Severi, L., ed., Perugia, Italy, Univ. of Perugia, 1966
Volume(issue)/page/year: -,869,1965
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4301
No. of Facilities: 7 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 28 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BENZOIN
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
:
:
:
:
DI1590000
Benzoin
119-53-9
0391839
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
4-08-00-01279 (Beilstein Handbook Reference)
199904
24
C14-H12-O2
212.26
QYR&VR
Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* Acetophenone, 2-hydroxy-2-phenyl* Benzoylphenylcarbinol
* Bitter almond oil camphor
* Ethanone, 2-hydroxy-1,2-diphenyl* Fenyl-alpha-hydroxybenzylketon
* alpha-Hydroxybenzyl phenyl ketone
* alpha-Hydroxy-alpha-phenylacetophenone
* 2-Hydroxy-2-phenylacetophenone
* Ketone, alpha-hydroxybenzyl phenyl
* NCI-C50011
* WY-42956
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 11,871,1973
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >3 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.11970Volume(issue)/page/year: 15,359,1984
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 8870 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 11,871,1973
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 750 ug/plate
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
5,187,1985
TYPE OF TEST
: Phage inhibition capacity
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 15600 ng/well
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
260,349,1991
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 25mg/L (+S9),
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
5,257,1985
TYPE OF TEST
: Gene conversion and mitotic recombination
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 250 mg/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
5,271,1985
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 63700 ug/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
5,353,1985
TYPE OF TEST
: DNA damage
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 500 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
224,379,1989
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 1 mmol/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
5,371,1985
TYPE OF TEST
: Unscheduled DNA synthesis
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 1 gm/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
320,189,1994
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 10 mg/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
5,569,1985
TYPE OF TEST
: Unscheduled DNA synthesis
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 500 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
224,379,1989
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 62500 ug/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
5,587,1985
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 20 mg/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
5,427,1985
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 500 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
13,133,1989
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 80585
No. of Facilities: 2083 (estimated)
No. of Industries: 25
No. of Occupations: 30
No. of Employees: 151846 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X9855
No. of Facilities: 6 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 42 (estimated)
No. of Female Employees: 18 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 80585
No. of Facilities: 189 (estimated)
No. of Industries: 4
No. of Occupations: 16
No. of Employees: 26840 (estimated)
No. of Female Employees: 22514 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative/limited: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-204,1980
BENZOIN OXIME
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
BEILSTEIN REFERENCE NO. :
REFERENCE
:
DI1750000
Benzoin, oxime
441-38-3
2051941
1-08-00-00573 (Beilstein Handbook Reference)
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
WISWESSER LINE NOTATION :
COMPOUND DESCRIPTOR
:
SYNONYMS/TRADE NAMES :
* Benzoinoxim
* Benzoin, alpha-oxime
* alpha-Benzoin oxime
* Cupron
* Cuprone
* USAF FA-5
199710
6
C14-H13-N-O2
227.28
QYR&YR&UNQ
Primary Irritant
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,698,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCNSA6 National Academy of Sciences, National Research Council,
Chemical-Biological Coordination Center, Review. (Washington, DC)
Volume(issue)/page/year: 5,9,1953
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD691-490
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
BENZONITRILE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
DI2450000
Benzonitrile
100-47-0
199812
24
C7-H5-N
103.13
NCR
Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* Benzene, cyano* Benzenenitrile
* Benzoic acid nitrile
* Cyanobenzene
* Fenylkyanid
* Phenyl cyanide
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Moderate
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 17,723,1979
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 720 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMRL** Aerospace Medical Research Laboratory Report. (Aerospace
Technical
Div., Air Force Systems Command, Wright-Patterson Air Force Base, OH
45433)
Volume(issue)/page/year: TR-74-78,1974
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 950 ppm/8H
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
REFERENCE :
AMRL** Aerospace Medical Research Laboratory Report. (Aerospace
Technical
Div., Air Force Systems Command, Wright-Patterson Air Force Base, OH
45433)
Volume(issue)/page/year: TR-74-78,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMRL** Aerospace Medical Research Laboratory Report. (Aerospace
Technical
Div., Air Force Systems Command, Wright-Patterson Air Force Base, OH
45433)
Volume(issue)/page/year: TR-74-78,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 740 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - acute pulmonary edema
REFERENCE :
APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353
Vineuil,
France) V.11943- Volume(issue)/page/year: 48,23,1990
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 971 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NEZAAQ Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. (Nippon
Eisei
Gakkai, c/o Kyoto Daigaku Igakubu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto
606,
Japan) V.11946- Volume(issue)/page/year: 39,423,1984
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1800 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 21(6),34,1977
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 17,723,1979
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 800 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 17,723,1979
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 800 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 17,723,1979
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 17,723,1979
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 17,723,1979
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LDLo - Lowest published lethal dose
: Subcutaneous
: Rodent - rabbit
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without
sensory
change
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 5,161,1899
V.4-
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Bird - pigeon
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 17,723,1979
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Amphibian - frog
DOSE/DURATION
: 1700 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without
sensory
change
Cardiac - other changes
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 5,161,1899
V.4-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 32(10),25,1988
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
TCLo - Lowest published toxic concentration
Inhalation
Rodent - rat
70 mg/m3/4H/19W-I
Liver - liver function tests impaired
Blood - normocytic anemia
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - cytochrome oxidases (including oxidative phosphorylation)
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 21(3),40,1977
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 70 mg/m3/4H/19W-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 21(6),34,1977
** MUTATION DATA **
TYPE OF TEST
: Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE
: Inhalation
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 168 ppm
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
403,149,1998
TYPE OF TEST
: Sex chromosome loss and nondisjunction
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 1580 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
241,255,1990
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 1 mg/m3 JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - A1153
No. of Facilities: 17 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 34 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
BENZOPHENONE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
DI9950000
Benzophenone
119-61-9
199907
15
C13-H10-O
182.23
RVR
Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* Benzene, benzoyl* Benzoylbenzene
* Diphenyl ketone
* Diphenylmethanone
* Ketone, diphenyl
* alpha-Oxodiphenylmethane
* alpha-Oxoditane
* Phenyl ketone
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 11,873,1973
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2895 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - tremor
Lungs, Thorax, or Respiration - other changes
REFERENCE :
EJTXAZ European Journal of Toxicology and Environmental Hygiene.
France) V.7-9, 1974-76. For publisher information, see TOERD9.
Volume(issue)/page/year: 9,99,1976
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Intraperitoneal
Rodent - mouse
727 mg/kg
(Paris,
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - tremor
Lungs, Thorax, or Respiration - other changes
REFERENCE :
EJTXAZ European Journal of Toxicology and Environmental Hygiene.
France) V.7-9, 1974-76. For publisher information, see TOERD9.
Volume(issue)/page/year: 9,99,1976
(Paris,
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 3535 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 11,873,1973
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 14 gm/kg/28D-C
TOXIC EFFECTS :
Blood - pigmented or nucleated red blood cells
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Blood - changes in erythrocyte (RBC) count
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.201982Volume(issue)/page/year:
29,741,1971
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 91 gm/kg/13W-C
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.11981- Volume(issue)/page/year: 14,221,1994
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 109 gm/kg/13W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.11981- Volume(issue)/page/year: 14,221,1994
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 75 mg/kg/15D-I
TOXIC EFFECTS :
Liver - other changes
Liver - hepatitis, fibrous (cirrhosis, post-necrotic scarring)
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 50,282,1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83170
No. of Facilities: 1495 (estimated)
No. of Industries: 8
No. of Occupations: 11
No. of Employees: 6944 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 83170
No. of Facilities: 1809 (estimated)
No. of Industries: 27
No. of Occupations: 50
No. of Employees: 41516 (estimated)
No. of Female Employees: 18162 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NTP Carcinogenesis studies; laboratory assigned, May 1999
NTP Carcinogenesis studies; test completed (post peer review), May 1999
BENZOPHENONE HYDRAZONENE
RTECS NUMBER
: PC4954487
CHEMICAL NAME
: Methanone, diphenyl-, hydrazone
CAS REGISTRY NUMBER
: 5350-57-2
LAST UPDATED
: 199906
DATA ITEMS CITED
: 1
MOLECULAR FORMULA
: C13-H12-N2
MOLECULAR WEIGHT
: 196.27
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
* Benzophenone, hydrazone
* Diphenyl ketone hydrazone
* Diphenylmethanone hydrazone
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 134 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation).
Translation
of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)
1967- Volume(issue)/page/year: 27,58,1993
No.1-
BENZOPINACOLE
RTECS NUMBER
: KI2750000
CHEMICAL NAME
: 1,2-Ethanediol, 1,1,2,2-tetraphenylCAS REGISTRY NUMBER
: 464-72-2
LAST UPDATED
: 199701
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C26-H22-O2
MOLECULAR WEIGHT
: 366.48
SYNONYMS/TRADE NAMES :
* Benzophenone pinacol
* Benzopinacol
* Benzopinacone
* alpha,alpha'-Bibenzhydrol
* Tetraphenyl-1,2-ethanediol
* 1,1,2,2-Tetraphenyl-1,2-ethanediol
* Tetraphenylethylene glycol
* 1,1,2,2-Tetraphenylethylene glycol
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJTXAZ European Journal of Toxicology and Environmental Hygiene. (Paris,
France) V.7-9, 1974-76. For publisher information, see TOERD9.
Volume(issue)/page/year: 9,99,1976
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Intraperitoneal
Rodent - mouse
>8 gm/kg
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJTXAZ European Journal of Toxicology and Environmental Hygiene. (Paris,
France) V.7-9, 1974-76. For publisher information, see TOERD9.
Volume(issue)/page/year: 9,99,1976
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BENZOPURPIN
RTECS NUMBER
CHEMICAL NAME
: QK1765000
: 1-Naphthalenesulfonic acid,
3,3'-((3,3'-dimethyl(1,1'-biphenyl)-4,4'-diyl)bis(azo
))bis (4-amino-, disodium salt
CAS REGISTRY NUMBER
: 992-59-6
LAST UPDATED
: 199710
DATA ITEMS CITED
: 6
MOLECULAR FORMULA
: C34-H26-N6-O6-S2.2Na
MOLECULAR WEIGHT
: 724.76
WISWESSER LINE NOTATION : L66J BZ ESWO CNUNR B1 DR C1 DNUN- CL66J BZ ESWO
&-NA2
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Amanil purpurine 4B
* Atul Direct Red 4B
* Azamin 4B
* Azocard Red 4B
* Bencidal purple 4B
* Benzanil purpurine 4B
* Benzopurpurin 4B
* Benzopurpurine 4B
* Benzopurpurine 4BKX
* Benzopurpurine 4BX
* Brasilamina Red 4B
* Calcomine Red 4BX
* Cerven prima 2
* Chrome Leather Red 4B
* C.I. 23500
* C.I. Direct Red 2
* Cotton Red 4B
* Diacotton benzopurpurine 4B
* Diamine purpurine 4B
* Diaphtamine purpurine
* Diazamine purpurine 4B
* Diazine Red 4B
* Diazol purpurine 4B
* Diphenyl Red 4B
* Diphenyl Red 4BS
* Direct Purpurine 4B
* Direct Purpurine M4B
* Direct Red 2
* Direct Red 4A
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
Direct Red 4B
Direct Red DCB
Ditolylbis(azonaphthionic acid)
Eclipse Red
Erie Benzo 4BP
Erie Red 4B
Fast Scarlet
Hispamin Red 4B
Kayaku benzopurpurine 4B
Mitsui benzopurpurine 4BX
Paper Red 4B
Phenamine purpurine 4B
Purpurin 4B
Purpurine 4B
Tertrodirect Red 4B
*** HEALTH HAZARD DATA ***
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 30 ug/plate
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 18,111,1986
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4706
No. of Facilities: 25 (estimated)
No. of Industries: 1
No. of Occupations: 4
No. of Employees: 1450 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Dyes, 5013
BENZOPYRANONE
RTECS NUMBER
: GB7887000
CHEMICAL NAME
: Chromone
CAS REGISTRY NUMBER
: 491-38-3
BEILSTEIN REFERENCE NO. : 0114087
REFERENCE
: 5-17-10-00139 (Beilstein Handbook Reference)
LAST UPDATED
: 199612
DATA ITEMS CITED
: 1
MOLECULAR FORMULA
: C9-H6-O2
MOLECULAR WEIGHT
: 146.15
WISWESSER LINE NOTATION : T66 BO EVJ
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
* 4H-1-Benzopyran-4-one
* Benzo-gamma-pyrone
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 91 mg/kg
TOXIC EFFECTS :
Behavioral - anticonvulsant
REFERENCE :
PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11961Volume(issue)/page/year:
9,65,1973
BENZOQUINONE (1,4-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
DK2625000
p-Benzoquinone
106-51-4
199907
61
C6-H4-O2
108.10
L6V DVJ
Agricultural Chemical
Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* Benzo-chinon
* 1,4-Benzoquine
* p-Benzoquinone
* 1,4-Benzoquinone
* Chinon
* Chinone
* p-Chinon
* Cyclohexadienedione
* 1,4-Cyclohexadienedione
* 2,5-Cyclohexadiene-1,4-dione
* 1,4-Cyclohexadiene dioxide
* 1,4-Diossibenzene
* 1,4-Dioxybenzene
* 1,4-Dioxy-benzol
* NCI-C55845
* Quinone
* p-Quinone
* Quinone
* RCRA waste number U197
* USAF P-220
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 130 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for
Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
Volume(issue)/page/year: 8,348,1949
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 30 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHBUA9 Pharmaceutical Bulletin. (Tokyo, Japan) V.1-5, 1953-57. For
publisher information, see CPBTAL. Volume(issue)/page/year: 3,337,1955
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for
Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
Volume(issue)/page/year: 8,348,1949
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5600 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
RPTOAN Russian Pharmacology and Toxicology (English Translation).
Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton,
Surrey,
UK) V.301967- Volume(issue)/page/year: 41,146,1978
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 23(5),14,1958
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 8500 ug/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without
sensory
change
Behavioral - muscle contraction or spasticity
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11958Volume(issue)/page/year:
12,885,1963
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 93800 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZGIMAL Zeitschrift fuer die Gesamte Innere Medizin und Ihre Grenzgebiete.
(Buchexport, Postfach 160, Leipzig DDR-7010, Ger. Dem. Rep.) V.11946Volume(issue)/page/year: 2,333,1947
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 296 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,25,1982
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 800 mg/kg/29W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Skin and Appendages - tumors
REFERENCE :
PIATA8 Proceedings of the Imperial Academy of Tokyo. (Tokyo, Japan)
V.1-21,
1912-45. For publisher information, see PJACAW. Volume(issue)/page/year:
16,309,1940
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 6326 mg/kg/43W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Skin and Appendages - tumors
REFERENCE :
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan)
V.1-75,
1907-84. For publisher information, see JJCREP.
Volume(issue)/page/year:
39,56,1948
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 8 mg/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
81,11,1981
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Human Bone marrow
DOSE/DURATION
: 100 umol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 12,1181,1991
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 5 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
45,2471,1985
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 5 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
45,2471,1985
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 20 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
208,61,1988
TYPE OF TEST
: Micronucleus test
TEST SYSTEM
: Rodent - mouse Embryo
DOSE/DURATION
: 50 umol/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
19(Suppl 20),21,1992
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - mouse Embryo
DOSE/DURATION
: 400 ug/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 16,477,1995
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 4 umol/L
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research.
(Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.11954Volume(issue)/page/year: 27,81,1986
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 5 umol/L
REFERENCE :
MOPMA3 Molecular Pharmacology. (Williams & Wilkins Co., 428 E. Preston
St.,
Baltimore, MD 21202) V.11965- Volume(issue)/page/year: 28,560,1985
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 10 umol/L
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
29,161,1985
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Rodent - mouse Cells - not otherwise specified
DOSE/DURATION
: 6 umol/L
REFERENCE :
CBTOE2 Cell Biology and Toxicology. (Princeton Scientific Pub., Inc.,
301
N. Harrison St., CN 5279, Princeton, NJ 08540) V.11984Volume(issue)/page/year: 2,231,1986
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 2100 nmol/L
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year:
3,193,1988
TYPE OF TEST
: Micronucleus test
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 6700 umol/L
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 82,81,1989
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Rodent - rabbit Bone marrow
DOSE/DURATION
: 2 umol/L
REFERENCE :
AJIMD8 American Journal of Industrial Medicine. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.11980- Volume(issue)/page/year:
7,485,1985
*** REVIEWS ***
ACGIH TLV-TWA 0.44 mg/m3 (0.1 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 15,255,1977
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 15,255,1977
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,56,1987
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.1 ppm (0.4 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,221,1971
OSHA PEL (Gen Indu):8H TWA 0.1 ppm (0.4 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 0.1 ppm (0.4 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 0.1 ppm (0.4 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 0.1 ppm (0.4 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 0.1 ppm (0.4 mg/m3) JAN 1993
OEL-AUSTRIA: MAK 0.1 ppm (0.4 mg/m3), JAN1999
OEL-AUSTRALIA:TWA 0.1 ppm (0.4 mg/m3) JAN 1993
OEL-AUSTRIA:TWA 0.1 ppm (0.4 mg/m3) JAN 1993
OEL-DENMARK: TWA 0.1 ppm (0.4 mg/m3), JAN1999
OEL-BELGIUM:TWA 0.1 ppm (0.44 mg/m3) JAN 1993
OEL-FINLAND:TWA 0.1 ppm (0.4 mg/m3);STEL 0.3 ppm;Skin JAN 1993
OEL-GERMANY:TWA 0.1 ppm (0.4 mg/m3) JAN 1993
OEL-THE NETHERLANDS:TWA 0.1 ppm (0.4 mg/m3) JAN 1993
OEL-POLAND: TWA 0.1 mg/m3, STEL 0.4 mg/m3, JAN1999
OEL-THE PHILIPPINES:TWA 5 ppm (15 mg/m3) JAN 1993
OEL-RUSSIA:STEL 0.05 mg/m3 JAN 1993
OEL-SWEDEN:TWA 0.1 ppm (0.4 mg/m3);STEL 0.3 ppm (1.3 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 0.1 ppm (0.4 mg/m3);STEL 0.2 ppm (0.8 mg/m3) JAN 1993
OEL-TURKEY:TWA 0.1 ppm (0.4 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 0.1 ppm (0.4 mg/m3);STEL 0.3 ppm JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO QUINONE-air:10H TWA 0.1 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 66950
No. of Facilities: 145 (estimated)
No. of Industries: 3
No. of Occupations: 6
No. of Employees: 3292 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 66950
No. of Facilities: 1228 (estimated)
No. of Industries: 17
No. of Occupations: 18
No. of Employees: 15511 (estimated)
No. of Female Employees: 1274 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
47,26992,82
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9079;8EHQ-0892-9083
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
BENZOTHIAZOLE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
DL0875000
Benzothiazole
95-16-9
0109468
4-27-00-01069 (Beilstein Handbook Reference)
199806
15
C7-H5-N-S
135.19
T56 BN DSJ
Primary Irritant
SYNONYMS/TRADE NAMES :
* Benzosulfonazole
* O-2857
* 1-Thia-3-azaindene
* USAF EK-4812
* Vangard BT
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 uL/24H
REACTION SEVERITY
: Mild
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0534825
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 uL/24H
REACTION SEVERITY
: Mild
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0534825
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 380 mg/kg
TOXIC EFFECTS :
Behavioral - food intake (animal)
Lungs, Thorax, or Respiration - pulmonary emboli
Liver - other changes
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0534825
TYPE OF TEST
: LC - Lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >1400 mg/m3/6H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EPASR* United States Environmental Protection Agency, Office of
Pesticides
and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St.,
SW,
Washington, DC 20460) History unknown. Volume(issue)/page/year:
8EHQ-1190-0987S
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 45,189,1932
V.1-
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Behavioral - irritability
Vascular - regional or general arteriolar or venous dilation
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
1909/10-
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 45,189,1932
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave.,
New
York, NY 10016) V.11977/78- Volume(issue)/page/year: 3,249,1980
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 95 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 105,486,1952
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 310 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KHFZAN Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical
Journal.
For English translation, see PCJOAU. (V/O Mezhdunarodnaya Kniga, 113095
Moscow, USSR) V.11967- Volume(issue)/page/year: 9(12),11,1975
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Vascular - regional or general arteriolar or venous dilation
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 45,189,1932
V.1-
1909/10-
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Behavioral - food intake (animal)
Lungs, Thorax, or Respiration - pulmonary emboli
Liver - other changes
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0534825
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84003
No. of Facilities: 5 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 69 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
BENZOTRIAZINONE (1,2,3:4,3H-)
RTECS NUMBER
: DM0800000
CHEMICAL NAME
: 1,2,3-Benzotriazin-4(1H)-one
CAS REGISTRY NUMBER
: 90-16-4
LAST UPDATED
: 199710
DATA ITEMS CITED
: 12
MOLECULAR FORMULA
: C7-H5-N3-O
MOLECULAR WEIGHT
: 147.15
WISWESSER LINE NOTATION : T66 BMNNVJ
COMPOUND DESCRIPTOR
: Drug
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Benzazimide
* Benzazimidone
* Benzoketotriazine
* 3H-1,2,3-Benzotriazin-4-one
* 4-Ketobenzotriazine
* USAF MA-2
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 595 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9,
Washington, DC 20231) Volume(issue)/page/year: #3794726
TYPE OF TEST
: LC - Lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >2 gm/kg/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0555463
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 222 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0555463
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Oral
Rodent - mouse
440 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9,
Washington, DC 20231) Volume(issue)/page/year: #3794726
TYPE OF TEST
: LC - Lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >2 gm/kg/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0555463
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689
TYPE OF TEST
: LC - Lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >2575 mg/kg/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0555463
TYPE OF TEST
: LC - Lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - hamster
DOSE/DURATION
: >2575 mg/kg/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0555463
** REPRODUCTIVE DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
TOXIC EFFECTS :
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - mouse
3480 mg/kg
male 8 day(s) pre-mating
female 21 day(s) pre-mating
Reproductive - Fertility - female fertility index (e.g. # females
pregnant
per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
MPHEAE Medicina et Pharmacologia Experimentalis. (Basel, Switzerland)
V.12-17, 1965-67. For publisher information, see PHMGBN.
Volume(issue)/page/year: 15,7,1966
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 2400 mg/kg
SEX/DURATION
: male 15 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - male fertility index (e.g. # males
impregnating
females per # males exposed to fertile nonpregnant females)
REFERENCE :
MPHEAE Medicina et Pharmacologia Experimentalis. (Basel, Switzerland)
V.12-17, 1965-67. For publisher information, see PHMGBN.
Volume(issue)/page/year: 15,7,1966
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
BENZOTRIAZOLE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
OTHER CAS REGISTRY NOS.
:
:
:
:
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
SYNONYMS/TRADE NAMES :
* 1,2,-Aminozophenylene
* Azimidobenzene
* Aziminobenzene
* Benzene azimide
* Benzisotriazole
* 1,2,3-Benzotriazole
* Benztriazole
* Cobratec #99
* 2,3-Diazaindole
* NCI-C03521
DM1225000
1H-Benzotriazole
95-14-7
25377-81-5
27556-51-0
0112133
4-26-00-00093 (Beilstein Handbook Reference)
199904
21
C6-H5-N3
119.14
T56 BMNNJ
Agricultural Chemical
Tumorigen
Mutagen
* NSC-3058
* 1,2,3-Triazaindene
* U-6233
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 560 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0516797
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1910 mg/m3/3H
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - structural or functional change in
trachea
or bronchi
Lungs, Thorax, or Respiration - dyspnea
Lungs, Thorax, or Respiration - other changes
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0520637
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0516745
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 615 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD-A067-313
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LD50 - Lethal dose, 50 percent kill
: Intraperitoneal
: Rodent - mouse
DOSE/DURATION
: 400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation,
see
PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.21939- Volume(issue)/page/year: 41,708,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 238 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 105,486,1952
V.1-
1909/10-
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 450 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0520182
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Autonomic Nervous System - other (direct) parasympathomimetic
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 46(11),70,1981
(V/O
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 109 mg/kg/26W-I
TOXIC EFFECTS :
Endocrine - other changes
Blood - normocytic anemia
Blood - leukopenia
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 46(11),70,1981
(V/O
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 220 gm/kg/78W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Brain and Coverings - tumors
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-88,1978
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 770 gm/kg/78W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Lungs, Thorax, or Respiration - bronchiogenic carcinoma
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-88,1978
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 100 ug/plate
REFERENCE :
IAPUDO IARC Publications. (WHO Publications Centre USA, 49 Sheridan
Ave.,
Albany, NY 12210) No.271979- Volume(issue)/page/year: 27,283,1980
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 33300 ng/plate
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 7(Suppl
5),1,1985
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - rat Embryo
DOSE/DURATION
: 94 ug/plate
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd.,
Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.11981Volume(issue)/page/year: 1,190,1981
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 5 mg/m3;Skin JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 82113
No. of Facilities: 1661 (estimated)
No. of Industries: 23
No. of Occupations: 33
No. of Employees: 5550 (estimated)
NOES - National Occupational
NOES Hazard Code - 82113
No. of Facilities: 17143
No. of Industries: 144
No. of Occupations: 107
No. of Employees: 279549
No. of Female Employees:
Exposure Survey (1983)
(estimated)
(estimated)
40869 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NCI Carcinogenesis Bioassay (feed);inadequate studies:mouse,rat
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-88,1978
BENZOXAZOLE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
* 1-Oxa-3-azaindene
* USAF EK-5017
:
:
:
:
:
:
:
:
:
DM4375000
Benzoxazole
273-53-0
199701
4
C7-H5-N-O
119.13
T56 BN DOJ
Drug
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 750 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MDCHAG Medicinal Chemistry: A Series of Monographs.
Inc.,
1 E. First St., Duluth, MN 55802) V.11963Volume(issue)/page/year:
4(1),336,1964
(Academic Press,
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MDCHAG Medicinal Chemistry: A Series of Monographs. (Academic Press,
Inc.,
1 E. First St., Duluth, MN 55802) V.11963Volume(issue)/page/year:
4(1),336,1964
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 179 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 105,486,1952
V.1-
1909/10-
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BENZOYL CHLORIDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
DM6600000
Benzoyl chloride
98-88-4
0471389
4-09-00-00721 (Beilstein Handbook Reference)
199712
22
C7-H5-Cl-O
140.57
GVR
Tumorigen
Mutagen
Human
SYNONYMS/TRADE NAMES :
* Benzaldehyde, alpha-chloro* Benzenecarbonyl chloride
* Benzoic acid, chloride
* Benzoyl chloride
* alpha-Chlorobenzaldehyde
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 2 ppm/1M
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Lungs, Thorax, or Respiration - other changes
REFERENCE :
TGNCDL "Handbook of Organic Industrial Solvents," 2nd ed., Chicago,
National
Assoc. of Mutual Casualty Companies, 1961 Volume(issue)/page/year:
2,31,1961
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection
Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)
Volume(issue)/page/year: FYI-OTS-1180-0107
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1870 mg/m3/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,25,1982
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 9200 mg/kg/50W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Skin and Appendages - tumors
REFERENCE :
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan)
V.1-75,
1907-84. For publisher information, see JJCREP.
Volume(issue)/page/year:
72,655,1981
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 17600 mg/kg/42W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan)
V.1-75,
1907-84. For publisher information, see JJCREP.
Volume(issue)/page/year:
72,655,1981
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 35200 mg/kg/42W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan)
V.1-75,
1907-84. For publisher information, see JJCREP.
Volume(issue)/page/year:
72,655,1981
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 1 umol/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
58,11,1978
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 5 mg/plate
REFERENCE :
TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection
Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)
Volume(issue)/page/year: FYI-OTS-1180-0107
*** REVIEWS ***
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-CL 2.8 mg/m3 (0.5 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996
TLV/BEI,1997
Volume(issue)/page/year:
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 29,83,1982
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 29,83,1982
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,56,1987
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-HUNGARY:TWA 5 mg/m3;STEL 10 mg/m3 JAN 1993
OEL-RUSSIA:STEL 5 mg/m3 JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 81724
No. of Facilities: 117 (estimated)
No. of Industries: 5
No. of Occupations: 6
No. of Employees: 1008 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 81724
No. of Facilities: 148 (estimated)
No. of Industries: 5
No. of Occupations: 30
No. of Employees: 6871 (estimated)
No. of Female Employees: 2826 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
47,26992,82
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
BENZOYL PEROXIDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
DM8575000
Benzoyl peroxide
94-36-0
199907
46
C14-H10-O4
242.24
RVOOVR
Tumorigen
Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* Acnegel
* Aztec BPO
* Benzoperoxide
* Benzoylperoxid
* Benzoyl peroxide
* Benzoylperoxyde
* Benzoyl superoxide
* BZF-60
* Cadat BPO
* Cadox B-CH 50
* Cadox BS
* Debroxide
* Dibenzoylperoxid
* Dibenzoyl peroxide
* Dibenzoylperoxyde
* Diphenylglyoxal peroxide
* Fostex
* Garox
* Incidol
* Loroxide
* Lucidol
* Luperco AA
* Luperco AST
* Luperox FL
* Nayper B and BO
* Norox bzp-250
* Norox bzp-C-35
* Novadelox
* Oxylite
* Panoxyl
* Perossido di benzoile
* Peroxide, dibenzoyl
* Peroxyde de benzoyle
* Persadox
* Quinolor compound
* Superox 744
* Theraderm
* Topex
* Vanoxide
* Xerac
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,324,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 7710 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - cyanosis
Liver - other changes
Kidney, Ureter, Bladder - other changes in urine composition
REFERENCE :
ARCOC* ARCO Chemical Company Report. (3801 West Chester Pike, Newton
Square, PA 19073) Volume(issue)/page/year: JUN1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 5700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 32(3),31,1967
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IPSTB3 International Polymer Science and Technology. (Rapra Technology
Ltd., Shawbury, Shrewsbury, Shropshire SY4 4NR, UK)
Volume(issue)/page/year:
3,93,1976
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: >1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650)
Volume(issue)/page/year: #900713
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 24 gm/kg/30W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.11895- Volume(issue)/page/year:
213,1023,1981
** MUTATION DATA **
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 250 ug/well
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
133,161,1984
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Human Cells - not otherwise specified
DOSE/DURATION
: 100 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
45,2522,1985
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human Cells - not otherwise specified
DOSE/DURATION
: 56 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
45,2522,1985
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Human Cells - not otherwise specified
DOSE/DURATION
: 56 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
45,2522,1985
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Human Kidney
DOSE/DURATION
: 300 umol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 13,1783,1992
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 100 pmol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 5,1547,1984
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - mouse Cells - not otherwise specified
DOSE/DURATION
: 1 umol/L
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research.
(Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.11954Volume(issue)/page/year: 24,108,1983
*** REVIEWS ***
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 5 mg/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 36,267,1985
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 36,267,1985
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,56,1987
TOXICOLOGY REVIEW
CMTVAS Cahiers de Medecine du Travail. (Association Professionnelle
Belge
des Medecine du Travail, rue du Bultia, 6280 Gerpinnes, Belgium) V.11963Volume(issue)/page/year: 10(3),49,1973
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 5 mg/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,23,1971
OSHA PEL (Gen Indu):8H TWA 5 mg/m3
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 5 mg/m3
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 5 mg/m3
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 5 mg/m3
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
41,50-204.50,1994
(U.S. Government Printing Office,
Volume(issue)/page/year:
(U.S. Government Printing Office,
Volume(issue)/page/year:
(U.S. Government Printing Office,
Volume(issue)/page/year:
(U.S. Government Printing Office,
Volume(issue)/page/year:
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 5 mg/m3 JAN 1993
OEL-AUSTRIA: MAK 5 mg/m3, JAN1999
OEL-AUSTRIA:TWA 5 mg/m3 JAN 1993
OEL-BELGIUM:TWA 5 mg/m3 JAN 1993
OEL-DENMARK: TWA 5 mg/m3, JAN1999
OEL-FINLAND:TWA 5 mg/m3;STEL 10 mg/m3;Skin JAN 1993
OEL-GERMANY:TWA 5 mg/m3 JAN 1993
OEL-HUNGARY:TWA 5 mg/m3;STEL 10 mg/m3;Skin JAN 1993
OEL-THE NETHERLANDS:TWA 5 mg/m3 JAN 1993
OEL-POLAND: MAC(TWA) 5 mg/m3, MAC(STEL) 10 mg/m3, JAN1999
OEL-THE PHILIPPINES:TWA 5 mg/m3 JAN 1993
OEL-SWITZERLAND:TWA 5 mg/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 5 mg/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO BENZOYL PEROXIDE-air:10H TWA 5 mg/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 11280
No. of Facilities: 5255 (estimated)
No. of Industries: 47
No. of Occupations: 42
No. of Employees: 32909 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 11280
No. of Facilities: 7331 (estimated)
No. of Industries: 62
No. of Occupations: 75
No. of Employees: 87420 (estimated)
No. of Female Employees: 11192 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Benzoyl peroxide, 5009
BENZOYLACETONE
RTECS NUMBER
: EK3540200
CHEMICAL NAME
: 1,3-Butanedione, 1-phenylCAS REGISTRY NUMBER
: 93-91-4
BEILSTEIN REFERENCE NO. : 0742413
REFERENCE
: 4-07-00-02151 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C10-H10-O2
MOLECULAR WEIGHT
: 162.20
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
* Acetoacetophenone
* alpha-Acetylacetophenone
*
*
*
*
2-Acetylacetophenone
Acetylbenzoylmethane
Benzoyl-aceton
Benzoylacetone
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCNSA6 National Academy of Sciences, National Research Council,
Chemical-Biological Coordination Center, Review. (Washington, DC)
Volume(issue)/page/year: 5,28,1953
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11958Volume(issue)/page/year:
14,1325,1965
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BENZYL ACETATE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
AF5075000
Acetic acid, benzyl ester
140-11-4
199904
37
C9-H10-O2
150.19
1VO1R
Tumorigen
Mutagen
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* Acetic acid, phenylmethyl ester
* alpha-Acetoxytoluene
* Benzyl acetate
* Benzyl acetate
* Benzylester kyseliny octove
* Benzyl ethanoate
* NCI-C06508
* Phenylmethyl acetate
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg/24H
REACTION SEVERITY
: Moderate
REFERENCE :
CTOIDG Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton,
IL
60189) V.911976- Volume(issue)/page/year: 94(8),41,1979
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 50 ppm
TOXIC EFFECTS :
Behavioral - antipsychotic
Lungs, Thorax, or Respiration - other changes
Kidney, Ureter, Bladder - other changes
REFERENCE :
TGNCDL "Handbook of Organic Industrial Solvents," 2nd ed., Chicago,
National
Assoc. of Mutual Casualty Companies, 1961 Volume(issue)/page/year:
2,31,1961
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2490 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 2,327,1964
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 830 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 50(7),17,1985
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LCLo - Lowest published lethal concentration
: Inhalation
: Rodent - mouse
(V/O
DOSE/DURATION
: 1300 mg/m3/22H
TOXIC EFFECTS :
Behavioral - general anesthetic
REFERENCE :
AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene.
V.1-18, 1930-61. For publisher information, see IAEHDW.
Volume(issue)/page/year: 5,1,1933
(Berlin, Ger.)
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 245 ppm/8H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21,
1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year:
21,28,1960
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 10 gm/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - muscle weakness
Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 84,358,1945
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 50(7),17,1985
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 11,875,1973
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LDLo - Lowest published lethal dose
: Subcutaneous
: Rodent - rabbit
DOSE/DURATION
: 4 gm/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene.
V.1-18, 1930-61. For publisher information, see IAEHDW.
Volume(issue)/page/year: 5,1,1933
(Berlin, Ger.)
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 2200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 50(7),17,1985
(V/O
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene. (Berlin, Ger.)
V.1-18, 1930-61. For publisher information, see IAEHDW.
Volume(issue)/page/year: 5,1,1933
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 355 gm/kg/13W-C
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-431,1993
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 65 gm/kg/13W-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-250,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
(Research
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 271 gm/kg/13W-C
TOXIC EFFECTS :
Behavioral - tremor
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-431,1993
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 28 gm/kg/14D-I
TOXIC EFFECTS :
Gastrointestinal - other changes
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-250,1986
(Research
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 4200 mg/kg/21D-I
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
Blood - pigmented or nucleated red blood cells
Blood - changes in erythrocyte (RBC) count
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 50(7),17,1985
(V/O
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 258 gm/kg/2Y-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Gastrointestinal - tumors
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-250,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 258 gm/kg/2Y-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Liver - tumors
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
(Research
(Research
Triangle Park, NC 27709) No.206NTP-TR-250,1986
Volume(issue)/page/year:
** MUTATION DATA **
TYPE OF TEST
: Phage inhibition capacity
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 6250 ng/well
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
260,349,1991
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Bacillus subtilis
DOSE/DURATION
: 21 mg/disc
REFERENCE :
OIGZDE Osaka-shi Igakkai Zasshi. Journal of Osaka City Medical
Association.
(Osaka-shi Igakkai, c/o Osaka-shiritsu Daigaku Igakubu, 1-4-54
Asahi-cho,
Abeno-ku, Osaka, 545, Japan) V.241975- Volume(issue)/page/year:
34,267,1985
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 1500 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
196,61,1988
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 500 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
196,61,1988
TYPE OF TEST
: Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 1600 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
343,157,1995
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 700 mg/L
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.11895- Volume(issue)/page/year:
236,933,1987
TYPE OF TEST
TEST SYSTEM
: Cytogenetic analysis
: Rodent - hamster Lung
DOSE/DURATION
: 600 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
369,243,1996
*** REVIEWS ***
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 61 mg/m3 (10 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 40,109,1986
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 40,109,1986
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,56,1987
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 5 mg/m3 JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 01600
No. of Facilities: 512 (estimated)
No. of Industries: 11
No. of Occupations: 42
No. of Employees: 93580 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 01600
No. of Facilities: 17141 (estimated)
No. of Industries: 107
No. of Occupations: 108
No. of Employees: 275806 (estimated)
No. of Female Employees: 133629 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NTP Carcinogenesis Studies (gavage);some evidence:mouse,rat
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-250,1986
NTP Carcinogenesis Studies (feed);no evidence:mouse,rat
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-431,1993
BENZYL ALCOHOL
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
(Research
DN3150000
Benzyl alcohol
100-51-6
0878307
4-06-00-02222 (Beilstein Handbook Reference)
199904
38
C7-H8-O
108.15
Q1R
Tumorigen
Mutagen
Reproductive Effector
Natural Product
Primary Irritant
SYNONYMS/TRADE NAMES :
* Benzal alcohol
* Benzenecarbinol
* Benzenemethanol
* Benzoyl alcohol
* Hydroxytoluene
* alpha-Hydroxytoluene
* Methanol, phenyl* NCI-C06111
* Phenolcarbinol
* Phenylcarbinol
* Phenylmethanol
* Phenylmethyl alcohol
* alpha-Toluenol
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
(Research
: Standard Draize test
: Administration onto the skin
: Human - man
DOSE/DURATION
: 16 mg/48H
REACTION SEVERITY
: Mild
REFERENCE :
CTOIDG Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton,
IL
60189) V.911976- Volume(issue)/page/year: 94(8),41,1979
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg/24H
REACTION SEVERITY
: Moderate
REFERENCE :
CTOIDG Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton,
IL
60189) V.911976- Volume(issue)/page/year: 94(8),41,1979
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Mammal - pig
DOSE/DURATION
: 100%
REACTION SEVERITY
: Moderate
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 11,1011,1973
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1230 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - excitement
Behavioral - coma
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 2,327,1964
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1000 ppm/8H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 4,119,1951
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974.
(National
Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair
Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
Volume(issue)/page/year: 1,6,1974
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1700 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - miosis (pupillary constriction)
Behavioral - coma
Kidney, Ureter, Bladder - other changes
REFERENCE :
RMSRA6 Revue Medicale de la Suisse Romande. (Societe Medicale de La
Suisse
Romande, 2 rue Bellefontaine, 1003 Lausanne, Switzerland) V.11881Volume(issue)/page/year: 15,561,1895
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 53 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
18,60,1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraarterial
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 441 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - chronic pulmonary edema
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
18,60,1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1360 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 50(7),81,1985
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Intraperitoneal
Rodent - mouse
650 mg/kg
(V/O
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical
Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.501961Volume(issue)/page/year: 75,702,1986
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 324 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 135,330,1962
V.4-
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 50 mg/kg
TOXIC EFFECTS :
Behavioral - ataxia
Lungs, Thorax, or Respiration - dyspnea
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
18,60,1971
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 9 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Lungs, Thorax, or Respiration - other changes
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
25,153,1973
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 10 gm/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - muscle weakness
Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
V.1-
1909/10-
Volume(issue)/page/year: 84,358,1945
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 625 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 16,1,1920
V.1-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1040 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
1909/10-
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 84,358,1945
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974.
(National
Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair
Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
Volume(issue)/page/year: 1,6,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 2500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 50(7),81,1985
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - wild bird species
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
21,315,1972
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2100 mg/kg/21D-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 50(7),81,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 13 gm/kg/13W-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-343,1989
(Research
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 24 mL/kg/12D-I
TOXIC EFFECTS :
Liver - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
REFERENCE :
CBPCEE Comparative Biochemistry and Physiology, C: Pharmacology,
Toxicology
and Endocrinology. (Elsevier Science, 660 White Plains Rd., Tarrytown, NY
10591) V.741983- Volume(issue)/page/year: 99,445,1991
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 12 gm/kg/16D-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-343,1989
** REPRODUCTIVE DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - mouse
6 gm/kg
(Research
SEX/DURATION
: female 6-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss,
Inc.,
41 E. 11th St., New York, NY 10003) V.11980Volume(issue)/page/year:
7,29,1987
** MUTATION DATA **
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Bacillus subtilis
DOSE/DURATION
: 21 mg/disc
REFERENCE :
OIGZDE Osaka-shi Igakkai Zasshi. Journal of Osaka City Medical
Association.
(Osaka-shi Igakkai, c/o Osaka-shiritsu Daigaku Igakubu, 1-4-54
Asahi-cho,
Abeno-ku, Osaka, 545, Japan) V.241975- Volume(issue)/page/year:
34,267,1985
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 10 mmol/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
24,181,1994
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 250 mg/L
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-343,1989
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 4 ug/L
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-343,1989
(Research
(Research
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 5 mg/m3;Skin JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 11360
No. of Facilities: 7284 (estimated)
No. of Industries: 85
No. of Occupations: 68
No. of Employees: 138757 (estimated)
NOES - National Occupational
NOES Hazard Code - 11360
No. of Facilities: 19005
No. of Industries: 128
No. of Occupations: 127
No. of Employees: 404916
No. of Female Employees:
Exposure Survey (1983)
(estimated)
(estimated)
236470 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NTP Carcinogenesis Studies (gavage);no evidence:mouse,rat
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-343,1989
BENZYL BENZOATE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
(Research
DG4200000
Benzoic acid, benzyl ester
120-51-4
2049280
4-09-00-00307 (Beilstein Handbook Reference)
199701
14
C14-H12-O2
212.26
RVO1R
Agricultural Chemical
Drug
Natural Product
SYNONYMS/TRADE NAMES :
* Ascabin
* Ascabiol
* Benylate
* Benzoic acid, phenylmethyl ester
* Benzyl alcohol benzoic ester
*
*
*
*
*
*
*
*
*
*
*
Benzyl benzenecarboxylate
Benzyl benzoate
Benzylester kyseliny benzoove
Benzylets
Benzyl phenylformate
Colebenz
Novoscabin
Peruscabin
Scabanca
Vanzoate
Venzonate
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1700 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 93,26,1948
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4 mL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 93,26,1948
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1400 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 93,26,1948
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
14CYAT "Industrial Hygiene and Toxicology," 2nd ed., Patty, F.A., ed.,
New
York, John Wiley & Sons, Inc., 1958-63
2,1897,1963
Volume(issue)/page/year:
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: >22440 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 84,358,1945
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 2240 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - muscle weakness
Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 84,358,1945
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1680 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 11,1015,1973
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 11,1015,1973
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 1 mL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 93,26,1948
V.1-
1909/10-
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 180 mL/kg/13W-I
TOXIC EFFECTS :
Behavioral - muscle weakness
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 93,26,1948
V.1-
1909/10-
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 11590
No. of Facilities: 264 (estimated)
No. of Industries: 7
No. of Occupations: 38
No. of Employees: 11292 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 11590
No. of Facilities: 5972 (estimated)
No. of Industries: 28
No. of Occupations: 50
No. of Employees: 83538 (estimated)
No. of Female Employees: 44948 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BENZYL BROMIDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
: XS7965000
: Toluene, alpha-bromo: 100-39-0
LAST UPDATED
: 199707
DATA ITEMS CITED
: 4
MOLECULAR FORMULA
: C7-H7-Br
MOLECULAR WEIGHT
: 171.05
WISWESSER LINE NOTATION : E1R
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Benzene, (bromomethyl)* (Bromomethyl)benzene
* Bromophenylmethane
* alpha-Bromotoluene
* omega-Bromotoluene
*** HEALTH HAZARD DATA ***
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 300 umol/L
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd.,
Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.11981Volume(issue)/page/year: 3,203,1983
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 1300 umol/L
REFERENCE :
ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie. (Berlin,
Fed. Rep. Ger.) V.76-92, 1971-78. For publisher information, see
JCROD7.
Volume(issue)/page/year: 92,177,1978
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 30 umol/L
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd.,
Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.11981Volume(issue)/page/year: 3,203,1983
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BENZYL BUTYRATE
RTECS NUMBER
: ES7350000
CHEMICAL NAME
: Butyric acid, benzyl ester
CAS REGISTRY NUMBER
: 103-37-7
BEILSTEIN REFERENCE NO. : 2047625
REFERENCE
: 4-06-00-02266 (Beilstein Handbook Reference)
LAST UPDATED
: 199709
DATA ITEMS CITED
: 5
MOLECULAR FORMULA
: C11-H14-O2
MOLECULAR WEIGHT
: 178.25
WISWESSER LINE NOTATION : 3VO1R
SYNONYMS/TRADE NAMES :
* Benzyl n-butanoate
* Benzyl butyrate
* Benzyl n-butyrate
* Benzylester kyseliny maselne
* Butanoic acid, phenylmethyl ester
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2330 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - tremor
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 2,327,1964
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 12,827,1974
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83173
No. of Facilities: 35 (estimated)
No. of Industries: 2
No. of Occupations: 29
No. of Employees: 4144 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 83173
No. of Facilities: 266 (estimated)
No. of Industries: 2
No. of Occupations: 10
No. of Employees: 8803 (estimated)
No. of Female Employees: 6358 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BENZYL CHLORIDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
XS8925000
Toluene, alpha-chloro100-44-7
199907
85
C7-H7-Cl
126.59
G1R
Tumorigen
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Benzene, (chloromethyl)* Benzile (cloruro di)
* Benzyl chloride
* Benzyle (chlorure de)
* Benzylchlorid
* Chloromethylbenzene
* Chlorophenylmethane
* alpha-Chlorotoluene
* omega-Chlorotoluene
* alpha-Chlortoluol
* Chlorure de benzyle
* NCI-C06360
* RCRA waste number P028
* Tolyl chloride
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1231 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB214-270
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 150 ppm/2H
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.1-
1972-
Volume(issue)/page/year: 11,217,1976
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZEKBAI Zeitschrift fuer Krebsforschung. (Berlin, Fed. Rep. Ger.)
V.1-75,
1903-71. For publisher information, see JCROD7.
Volume(issue)/page/year:
74,241,1970
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 625 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 44(3),11,1979
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,25,1982
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 80 ppm/2H
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 11,217,1976
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 780 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
(V/O
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 44(3),11,1979
(V/O
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 400 ppm/8H
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - corneal damage
Lungs, Thorax, or Respiration - acute pulmonary edema
Lungs, Thorax, or Respiration - cough
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0572390
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 10 mL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0572390
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 40(1),92,1975
(V/O
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 390 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 30(3),6,1986
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4836 mg/kg/26W-I
TOXIC EFFECTS :
Cardiac - other changes
Gastrointestinal - necrotic changes
Related to Chronic Data - death
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 76,1231,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 7800 mg/kg/26W-I
TOXIC EFFECTS :
Liver - other changes
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 76,1231,1986
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 46 ppm/6H/14D-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd.,
Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.11981Volume(issue)/page/year: 15,207,1995
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 50 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 6,576,1968
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 31 gm/kg/2Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Vascular - tumors
Gastrointestinal - tumors
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 76,1231,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 9200 mg/kg/50W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Skin and Appendages - tumors
REFERENCE :
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan)
V.1-75,
1907-84. For publisher information, see JJCREP.
Volume(issue)/page/year:
72,655,1981
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2100 mg/kg/53W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
ZEKBAI Zeitschrift fuer Krebsforschung. (Berlin, Fed. Rep. Ger.)
V.1-75,
1903-71. For publisher information, see JCROD7.
Volume(issue)/page/year:
74,241,1970
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1 gm/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 17,51,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 11 ug/kg
SEX/DURATION
: female 1-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 44(3),11,1979
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
:
:
:
:
TDLo - Lowest published toxic dose
Intraperitoneal
Rodent - mouse
250 mg/kg
(V/O
SEX/DURATION
: male 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
100,345,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 2500 mg/kg
SEX/DURATION
: male 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
100,345,1982
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 7900 nmol/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
58,143,1978
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 666 ug/plate
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 9(Suppl
9),1,1987
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 6300 nmol/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
58,143,1978
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 10 mg/L
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 62,873,1979
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Bacillus subtilis
DOSE/DURATION
: 79200 nmol/disc
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
58,143,1978
TYPE OF TEST
: Gene conversion and mitotic recombination
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 400 ppm
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 62,901,1979
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Human Fibroblast
DOSE/DURATION
: 1 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
145,209,1985
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Human Cells - not otherwise specified
DOSE/DURATION
: 1 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
145,209,1985
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Human HeLa cell
DOSE/DURATION
: 50 umol/L
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub.
Ireland
Ltd., POB 85, Limerick, Ireland) V.11975- Volume(issue)/page/year:
20,263,1983
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - rat Cells - not otherwise specified
DOSE/DURATION
: 120 umol/L
REFERENCE :
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc.,
52
Vanderbilt Ave., New York, NY 10017) V.11981Volume(issue)/page/year:
4,247,1982
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 393 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
203,155,1988
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 8 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
11,91,1988
TYPE OF TEST
: Micronucleus test
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 1 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
203,397,1988
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 1600 ug/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 1,323,1980
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 100 umol/L
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd.,
Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.11981Volume(issue)/page/year: 3,203,1983
*** REVIEWS ***
ACGIH TLV-Animal carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 5.2 mg/m3 (1 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 29,49,1982
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.1-
1972-
Volume(issue)/page/year: 29,49,1982
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 1 ppm (5 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,24,1971
OSHA PEL (Gen Indu):8H TWA 1 ppm (5 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 1 ppm (5 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 1 ppm (5 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 1 ppm (5 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 1 ppm (5 mg/m3) JAN 1993
OEL-AUSTRIA: Carcinogen, JAN1999
OEL-AUSTRIA:TWA 1 ppm (5 mg/m3) JAN 1993
OEL-BELGIUM:TWA 1 ppm (5.2 mg/m3) JAN 1993
OEL-DENMARK: TWA 1 ppm (5 mg/m3), JAN1999
OEL-FRANCE: VME 1 ppm (5 mg/m3), VLE 2 ppm (11 mg/m3), C3 Carcinogen,
JAN1999
OEL-FINLAND:TWA 1 ppm (5 mg/m3);STEL 3 ppm (15 mg/m3) JAN 1993
OEL-GERMANY:TWA 1 ppm (5 mg/m3);Carcinogen JAN 1993
OEL-POLAND: MAC(TWA) 3 mg/m3, CEILING 5 mg/m3, JAN1999
OEL-HUNGARY:STEL 0.5 mg/m3;Skin JAN 1993
OEL-THE NETHERLANDS:TWA 1 ppm (5 mg/m3) JAN 1993
OEL-THE PHILIPPINES:TWA 1 ppm (5 mg/m3) JAN 1993
OEL-RUSSIA:STEL 0.5 mg/m3 JAN 1993
OEL-SWEDEN:TWA 1 ppm (5 mg/m3);STEL 2 ppm (11 mg/m3);Carcinogen JAN 1993
OEL-SWITZERLAND:TWA 1 ppm (5 mg/m3);STEL 2 ppm (10 mg/m3) JAN 1993
OEL-TURKEY:TWA 1 ppm (5 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 1 ppm (3 mg/m3);STEL 2 ppm (6 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 1 ppm (5 mg/m3) JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO BENZYL CHLORIDE-air:CL 1 ppm/15M
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 11600
No. of Facilities: 172 (estimated)
No. of Industries: 5
No. of Occupations: 10
No. of Employees: 30504 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 11600
No. of Facilities: 1877 (estimated)
No. of Industries: 29
No. of Occupations: 25
No. of Employees: 41075 (estimated)
No. of Female Employees: 8440 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: SHE-clonal assay; B subtilis rec
assay
EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9; E coli polA
with
S9
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: In vitro UDS-human fibroblast; S
cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Negative: Host-mediated assay
EPA GENETOX PROGRAM 1988, Inconclusive: CHO gene mutation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
47,26992,82
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9001;8EHQ-0892-8910
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Hydrocarbons, halogenated, 1003
NCI Carcinogenesis Studies (feed);clear evidence:mouse
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 76,1231,1986
NCI Carcinogenesis Studies (feed);inadequate:rat
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 76,1231,1986
BENZYL CYANIDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
AM1400000
Acetonitrile, phenyl140-29-4
199812
22
C8-H7-N
117.16
NC1R
Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* Benzeneacetonitrile
* Benzyl cyanide
* Benzylkyanid
* Benzyl nitrile
* (Cyanomethyl)benzene
* alpha-Cyanotoluene
* omega-Cyanotoluene
* Phenylacetonitrile
* 2-Phenylacetonitrile
* Phenyl acetyl nitrile
* Toluene, alpha-cyano-
* alpha-Tolunitrile
* USAF KF-21
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.201982Volume(issue)/page/year:
20,803,1982
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 270 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
Liver - other changes
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 32(8),20,1967
(V/O
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 430 mg/m3/2H
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - muscle contraction or spasticity
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA.
(Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year:
32(7-9),176,1967
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.201982Volume(issue)/page/year:
20,803,1982
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 74982 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
Behavioral - changes in motor activity (specific assay)
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
10,265,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 45500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
55,47,1984
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 100 mg/m3/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,25,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 32 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 12,447,1904
V.4-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 270 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.201982Volume(issue)/page/year:
20,803,1982
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 50 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without
sensory
change
Behavioral - ataxia
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 5,161,1899
V.4-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 10 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0570995
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 5 mL/kg
TOXIC EFFECTS :
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0570995
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LDLo - Lowest published lethal dose
: Intramuscular
: Bird - pigeon
DOSE/DURATION
: 120 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell
House,
Fairview Park, Elmsford, NY 10523) V.201982Volume(issue)/page/year:
20,803,1982
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Amphibian - frog
DOSE/DURATION
: 1100 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without
sensory
change
Behavioral - ataxia
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie.
(Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)
1898- Volume(issue)/page/year: 5,161,1899
V.4-
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 60 mg/m3/2H/4W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - structural or functional change in
trachea
or bronchi
Liver - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 32(8),20,1967
** MUTATION DATA **
TYPE OF TEST
: Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE
: Inhalation
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 170 ppm
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
403,149,1998
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 0.8 mg/m3;Skin JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83175
No. of Facilities: 41 (estimated)
No. of Industries: 2
No. of Occupations: 3
No. of Employees: 705 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 83175
No. of Facilities: 28 (estimated)
No. of Industries: 2
No. of Occupations: 10
No. of Employees: 5911 (estimated)
No. of Female Employees: 1005 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
BENZYL ISOBUTYRATE
RTECS NUMBER
: NQ4550000
CHEMICAL NAME
: Isobutyric acid, benzyl ester
CAS REGISTRY NUMBER
: 103-28-6
BEILSTEIN REFERENCE NO. : 1869299
REFERENCE
: 4-06-00-02266 (Beilstein Handbook Reference)
LAST UPDATED
: 199709
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C11-H14-O2
MOLECULAR WEIGHT
: 178.25
WISWESSER LINE NOTATION : 1Y1&VO1R
SYNONYMS/TRADE NAMES :
* Benzylester kyseliny isomaselne
* Benzyl isobutyrate
* Benzyl isobutanoate
* Benzyl 2-methyl propionate
* Propanoic acid, 2-methyl-, phenylmethyl ester
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2850 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 11,1023,1973
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83176
No. of Facilities: 127 (estimated)
No. of Industries: 3
No. of Occupations: 29
No. of Employees: 4419 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BENZYL MERCAPTAN
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
XT8650000
alpha-Toluenethiol
100-53-8
0605864
4-06-00-02632 (Beilstein Handbook Reference)
199701
9
C7-H8-S
124.21
SH1R
Tumorigen
Primary Irritant
SYNONYMS/TRADE NAMES :
* Benzylhydrosulfide
* Benzyl mercaptan
* Benzylthiol
* (Mercaptomethyl)benzene
* alpha-Mercaptotoluene
* Methanethiol, phenyl* Phenylmethanethiol
* Phenylmethyl mercaptan
* Thiobenzyl alcohol
* alpha-Toluolthiol
* alpha-Tolyl mercaptan
* USAF EK-1509
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 106 mg
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
19,171,1958
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 493 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - respiratory depression
Behavioral - coma
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
19,171,1958
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 373 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - respiratory depression
Behavioral - coma
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
19,171,1958
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 178 ppm/4H
TOXIC EFFECTS :
Behavioral - muscle weakness
Behavioral - ataxia
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
19,171,1958
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689
** TUMORIGENIC DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
TDLo - Lowest published toxic dose
Administration onto the skin
Rodent - mouse
16 gm/kg/26W-I
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
Tumorigenic - tumors at site of application
REFERENCE :
AJCAA7 American Journal of Cancer. (New York, NY) V.15-40, 1931-40.
For
publisher information, see CNREA8. Volume(issue)/page/year: 15,2149,1931
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - T0905
No. of Facilities: 7 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 28 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
BENZYL NICOTINATE
RTECS NUMBER
: QT0850000
CHEMICAL NAME
: Nicotinic acid, benzyl ester
CAS REGISTRY NUMBER
: 94-44-0
BEILSTEIN REFERENCE NO. : 0159169
REFERENCE
: 5-22-02-00062 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C13-H11-N-O2
MOLECULAR WEIGHT
: 213.25
WISWESSER LINE NOTATION : T6NJ CVO1R
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
* Benzyl nicotinate
* Benzyl pyridine-3-carboxylate
* Estru benzylowego kwasu nikotynowego
* Niacin benzyl ester
* Pycaril
* Pykaryl
* 3-Pyridinecarboxylic acid, phenylmethyl ester
* Rubriment
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Oral
Rodent - mouse
2188 mg/kg
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001,
00-068
Warsaw 1, Poland) V.41971- Volume(issue)/page/year: 12,79,1979
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18,
Berlin DDR-1020, Ger. Dem. Rep.) V.11946- Volume(issue)/page/year:
11,242,1956
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BENZYL SALICYLATE
RTECS NUMBER
: VO1750000
CHEMICAL NAME
: Salicylic acid, benzyl ester
CAS REGISTRY NUMBER
: 118-58-1
BEILSTEIN REFERENCE NO. : 2115365
REFERENCE
: 4-10-00-00157 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 4
MOLECULAR FORMULA
: C14-H12-O3
MOLECULAR WEIGHT
: 228.26
WISWESSER LINE NOTATION : QR BVO1R
SYNONYMS/TRADE NAMES :
* Benzyl o-hydroxybenzoate
* Benzyl salicylate
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2227 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 11,1029,1973
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 82924
No. of Facilities: 71 (estimated)
No. of Industries: 4
No. of Occupations: 25
No. of Employees: 6137 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 82924
No. of Facilities: 5081 (estimated)
No. of Industries: 20
No. of Occupations: 46
No. of Employees: 74153 (estimated)
No. of Female Employees: 42575 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BENZYL SULFIDE
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
SYNONYMS/TRADE NAMES :
* Benzyl monosulfide
* Benzyl sulfide
* Benzyl thioether
* Dibenzyl monosulfide
* Dibenzyl sulfide
* Dibenzyl thioether
DC0512500
Benzene, 1,1'-(thiobis(methylene))bis538-74-9
199709
2
C14-H14-S
214.34
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >2 gm/kg
TOXIC EFFECTS :
Skin and Appendages - hair
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of
Toxicology,
Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)
V.11990- Volume(issue)/page/year: 15(Suppl 1),S89,1996
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BENZYL SULFOXIDE
RTECS NUMBER
: DA9275000
CHEMICAL NAME
: Benzene, 1,1'-(sulfinylbis(methylene))bisCAS REGISTRY NUMBER
: 621-08-9
BEILSTEIN REFERENCE NO. : 2049262
REFERENCE
: 4-06-00-02651 (Beilstein Handbook Reference)
LAST UPDATED
: 199709
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C14-H14-O-S
MOLECULAR WEIGHT
: 230.34
WISWESSER LINE NOTATION : R1SO&1R
SYNONYMS/TRADE NAMES :
* Benzyl sulfoxide
* Bis(phenylmethyl) sulfoxide
* Dibenzylsulfoxide
* Dibenzyl sulphoxide
* Sulfoxide, dibenzyl
* Tardiol D
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IJRBA3 International Journal of Radiation Biology and Related Studies in
Physics, Chemistry and Medicine. (Taylor & Francis Inc., 242 Cherry St.,
Philadelphia, PA 19106) V.11959- Volume(issue)/page/year:
3,41,1961
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BENZYLAMINE
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
BEILSTEIN REFERENCE NO. :
REFERENCE
:
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
SYNONYMS/TRADE NAMES :
* (Aminomethyl)benzene
DP1488500
Benzylamine
100-46-9
0741984
4-12-00-02155 (Beilstein Handbook Reference)
199710
7
C7-H9-N
107.17
*
*
*
*
*
*
*
alpha-Aminotoluene
omega-Aminotoluene
Benzenemethanamine
Monobenzylamine
(Phenylmethyl)amine
Sumine 2005
Sumine 2006
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9,
Washington, DC 20231) Volume(issue)/page/year: #3816470
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 39(4),86,1974
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M2937
No. of Facilities: 369 (estimated)
No. of Industries: 7
No. of Occupations: 7
No. of Employees: 932 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M2937
No. of Facilities: 87 (estimated)
No. of Industries: 3
No. of Occupations: 7
No. of Employees: 5721 (estimated)
No. of Female Employees: 844 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
(V/O
BENZYLAMINE HYDROCHLORIDE
RTECS NUMBER
: DP5425000
CHEMICAL NAME
: Benzylamine, hydrochloride
CAS REGISTRY NUMBER
: 3287-99-8
LAST UPDATED
: 199701
DATA ITEMS CITED
: 4
MOLECULAR FORMULA
: C7-H9-N.Cl-H
MOLECULAR WEIGHT
: 143.63
WISWESSER LINE NOTATION : Z1R &GH
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
* Benzenemethanamine, hydrochloride
* Benzylammonium chloride
* USAF EL-82
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 220 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353
Vineuil,
France) V.11943- Volume(issue)/page/year: 9,390,1951
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 82149
No. of Facilities: 314 (estimated)
No. of Industries: 4
No. of Occupations: 3
No. of Employees: 3082 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BENZYLAMINOPURINE (6-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
AU6252200
Adenine, N-benzyl1214-39-7
199706
8
C12-H11-N5
225.28
Agricultural Chemical
Mutagen
SYNONYMS/TRADE NAMES :
* ABG 3034
* Adenine, N(sup 6)-benzyl* 6-BA
* BA (Growth stimulant)
* 6-BAP
* BAP (growth stimulant)
* Benzyladenine
* N-Benzyladenine
* N(sup 6)-Benzyladenine
* 6-Benzyladenine
* Benzylaminopurine
* N(sup 6)-(Benzylamino)purine
* 6-(Benzylamino)purine
* 6-(N-Benzylamino)purine
* Cytokinin B
* N-(Phenylmethyl)-1H-purin-6-amine
* Pro-Shear
* 1H-Purin-6-amine, N-(phenylmethyl)* SD 4901
* SQ 4609
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2125 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Behavioral - somnolence (general depressed activity)
REFERENCE :
TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho
University.
(Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143,
Japan) V.11954- Volume(issue)/page/year: 19,336,1972
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1300 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Behavioral - somnolence (general depressed activity)
REFERENCE :
TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho
University.
(Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143,
Japan) V.11954- Volume(issue)/page/year: 19,336,1972
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho
University.
(Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143,
Japan) V.11954- Volume(issue)/page/year: 19,336,1972
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >2300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho
University.
(Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143,
Japan) V.11954- Volume(issue)/page/year: 19,336,1972
** MUTATION DATA **
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
EXPEAM Experientia.
Switzerland) V.1TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
EXPEAM Experientia.
Switzerland) V.1-
: Mutation test systems - not otherwise specified
: Human Leukocyte
: 100 nmol/L
(Birkhaeuser Verlag, POB 133, CH-4010 Basel,
1945- Volume(issue)/page/year: 32,29,1976
: Mutation test systems - not otherwise specified
: Human Leukocyte
: 10 umol/L
(Birkhaeuser Verlag, POB 133, CH-4010 Basel,
1945- Volume(issue)/page/year: 32,29,1976
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BENZYLFORMIC ACID
RTECS NUMBER
: DA1480000
CHEMICAL NAME
: Benzeneglyoxylic acid
CAS REGISTRY NUMBER
: 611-73-4
BEILSTEIN REFERENCE NO. : 0606718
REFERENCE
: 4-10-00-02737 (Beilstein Handbook Reference)
LAST UPDATED
: 199904
DATA ITEMS CITED
: 1
MOLECULAR FORMULA
: C8-H6-O3
MOLECULAR WEIGHT
: 150.14
WISWESSER LINE NOTATION : QVVR
SYNONYMS/TRADE NAMES :
* Benzeneacetic acid, alpha-oxo* Benzoylformic acid
* Glyoxylic acid, phenyl* alpha-Ketophenylacetic acid
* alpha-Oxobenzeneacetic acid
* Oxophenylacetic acid
* Phenylglyoxylic acid
* Phenyloxoacetic acid
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD
21010)
Volume(issue)/page/year: NX#04110
BENZYLHYDROXYLAMINE DIHYDROCHLORIDE (N-)
RTECS NUMBER
: MU8540000
CHEMICAL NAME
: Hydrazine, benzyl-, dihydrochloride
CAS REGISTRY NUMBER
: 20570-96-1
LAST UPDATED
: 198910
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C7-H10-N2.2Cl-H
MOLECULAR WEIGHT
: 195.11
WISWESSER LINE NOTATION : ZM1R &GH 2
COMPOUND DESCRIPTOR
: Tumorigen
Drug
Mutagen
SYNONYMS/TRADE NAMES :
* Benzylhydrazine dihydrochloride
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 11 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
Behavioral - antipsychotic
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington,
DC
20037) V.61963- Volume(issue)/page/year: 18,20,1975
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 10 gm/kg/29W-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Blood - lymphoma, including Hodgkin's disease
REFERENCE :
ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie. (Berlin,
Fed. Rep. Ger.) V.76-92, 1971-78. For publisher information, see
JCROD7.
Volume(issue)/page/year: 87,267,1976
** MUTATION DATA **
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Bacteria - Bacillus subtilis
DOSE/DURATION
: 10 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
5,343,1968
BENZYLHYDROXYLAMINE HYDROCHLORIDE (ORTHO-)
RTECS NUMBER
: NC3040000
CHEMICAL NAME
: Hydroxylamine, O-benzyl-, hydrochloride
CAS REGISTRY NUMBER
: 2687-43-6
LAST UPDATED
: 199012
DATA ITEMS CITED
: 1
MOLECULAR FORMULA
: C7-H9-N-O.Cl-H
MOLECULAR WEIGHT
: 159.63
WISWESSER LINE NOTATION : ZO1R &GH
SYNONYMS/TRADE NAMES :
* O-Benzylhydroxylamine hydrochloride
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD691-490
BENZYLIDENEACETONE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
EN0330000
3-Buten-2-one, 4-phenyl122-57-6
0742046
2-07-00-00287 (Beilstein Handbook Reference)
199710
9
C10-H10-O
146.20
1V1U1R
Drug
Primary Irritant
SYNONYMS/TRADE NAMES :
* Benzalaceton
* Benzalacetone
* Benzylidene acetone
* 4-Phenyl-3-buten-2-one
* Styryl methyl ketone
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 11,1021,1973
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 1%/48H
REACTION SEVERITY
: Moderate
REFERENCE :
JSCCA5 Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic
Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.11947-
Volume(issue)/page/year: 28,357,1977
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2031 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
Vascular - regional or general arteriolar or venous dilation
Skin and Appendages - hair
REFERENCE :
EPASR* United States Environmental Protection Agency, Office of
Pesticides
and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St.,
SW,
Washington, DC 20460) History unknown. Volume(issue)/page/year:
8EHQ-0391-1194
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1210 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 19,617,1969
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 112 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 19,617,1969
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83179
No. of Facilities: 41 (estimated)
No. of Industries: 3
No. of Occupations: 5
No. of Employees: 550 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 83179
No. of Facilities: 196 (estimated)
No. of Industries: 7
No. of Occupations: 10
No. of Employees: 5458 (estimated)
No. of Female Employees: 2178 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
BENZYLISOTHIOUREA HYDROCHLORIDE
RTECS NUMBER
: UM0738000
CHEMICAL NAME
: Pseudourea, 2-benzyl-2-thio-, monohydrochloride
CAS REGISTRY NUMBER
: 538-28-3
LAST UPDATED
: 199701
DATA ITEMS CITED
: 6
MOLECULAR FORMULA
: C8-H10-N2-S.Cl-H
MOLECULAR WEIGHT
: 202.72
WISWESSER LINE NOTATION : MUYZS1R &GH
SYNONYMS/TRADE NAMES :
* Benzylisothiourea hydrochloride
* Benzylisothiouronium chloride
* 2-Benzylisothiouronium chloride
* Benzyl thiopseudourea hydrochloride
* Benzylthiuronium chloride
* S-Benzylthiuronium chloride
* BTKH
* Isothiouronium chloride, benzyl* Pseudourea, 2-benzyl-2-thio-, hydrochloride
* Pseudourea, 2-thio-2-benzyl-, hydrochloride
* TL 944
* USAF EK-2124
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 27 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 27(2),52,1983
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 170 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
URXXAF U.S.S.R. Patent Document. (Gosudarstvennyi Komitet SSSR po Delam
Izobretenii i Otkrytii, Malyi Tcherkasski pereulok 2/6, Moscow, Russia).
Volume(issue)/page/year: #0822829
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 80 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NDRC** National Defense Research Committee, Office of Scientific Research
and Development, Progress Report. Volume(issue)/page/year:
No.9-4-1-9,1943
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 32 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD
21010)
Volume(issue)/page/year: NX#00167
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BENZYLPENICILLENIC ACID
RTECS NUMBER
CHEMICAL NAME
acid,
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
: XH9400000
: 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic
:
:
:
:
:
:
:
:
:
3,3-dimethyl-7-oxo-6- (2-phenylacetamido)61-33-6
0044740
4-27-00-05861 (Beilstein Handbook Reference)
199612
24
C16-H18-N2-O4-S
334.42
T45 ANV ESTJ CMV1R& F F GVQ
Tumorigen
Drug
Mutagen
Human
Natural Product
SYNONYMS/TRADE NAMES :
* Abbocillin
* Benzopenicillin
* Benzyl-6-aminopenicillinic acid
* Benzylpenicillin
* (5R,6R)-Benzylpenicillin
* Benzylpenicillin G
* Benzylpenicillinic acid
* Cilloral
* Cilopen
* Compocillin G
* Cosmopen
* Dropcillin
* Free benzylpenicillin
* Free penicillin G
* Free penicillin II
* Galofak
* Gelacillin
* Liquacillin
* Pencillin G
* Penicillin G
* Penicillinic acid, benzyl* Pharmacillin
* Phenylacetamidopenicillanic acid
* (Phenylmethyl)penicillin
* (Phenylmethyl)penicillinic acid
* Pradupen
* Specilline G
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Human - child
DOSE/DURATION
: 15000 units/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Ear) - changes in cochlear structure or
function
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.11823Volume(issue)/page/year: 1,394,1986
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 8 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC)
V.1-12, 1951-62. For publisher information, see CLMEA3.
Volume(issue)/page/year: 12,249,1962
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 9 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher
information, see AMBIEH. Volume(issue)/page/year: 23,317,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AACHAX Antimicrobial Agents and Chemotherapy (1961-70). (Ann Arbor, MI)
1961-70. For publisher information, see AMACCQ.
Volume(issue)/page/year:
-,619,1967
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AACHAX Antimicrobial Agents and Chemotherapy (1961-70). (Ann Arbor, MI)
1961-70. For publisher information, see AMACCQ.
Volume(issue)/page/year:
-,619,1967
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 329 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11958Volume(issue)/page/year:
16,1365,1967
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intracerebral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 5700 ug/kg
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
REFERENCE :
JLCMAK Journal of Laboratory and Clinical Medicine. (C.V. Mosby Co.,
11830
Westline Industrial Dr., St. Louis, MO 63141) V.11915Volume(issue)/page/year: 34,126,1949
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 7800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher
information, see AMBIEH. Volume(issue)/page/year: 23,317,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intracerebral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 1118 ug/kg
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
REFERENCE :
JLCMAK Journal of Laboratory and Clinical Medicine. (C.V. Mosby Co.,
11830
Westline Industrial Dr., St. Louis, MO 63141) V.11915Volume(issue)/page/year: 34,126,1949
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 4940 ug/kg
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
REFERENCE :
JLCMAK Journal of Laboratory and Clinical Medicine. (C.V. Mosby Co.,
11830
Westline Industrial Dr., St. Louis, MO 63141) V.11915Volume(issue)/page/year: 34,126,1949
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intracerebral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 653 ug/kg
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
REFERENCE :
JLCMAK Journal of Laboratory and Clinical Medicine. (C.V. Mosby Co.,
11830
Westline Industrial Dr., St. Louis, MO 63141) V.11915Volume(issue)/page/year: 34,126,1949
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 38 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 42(9),10,1977
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
(V/O
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - hamster
DOSE/DURATION
: 24 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - food intake (animal)
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
14,510,1969
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - hamster
DOSE/DURATION
: 96 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - food intake (animal)
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
14,510,1969
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 104 ku/kg/4D-I
TOXIC EFFECTS :
Blood - changes in other cell count (unspecified)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
REFERENCE :
AMBIEH Antibiotiki i Meditsinskaya Biotekhnologiya. Antibiotics and
Medical
Biotechnology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.30-V.32,
1985-1987 Volume(issue)/page/year: 30,449,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 750 units/kg/5D-I
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Immunological Including Allergic - decrease in humoral immune response
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
REFERENCE :
ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher
information, see AMBIEH. Volume(issue)/page/year: 29,350,1984
** TUMORIGENIC DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
: TDLo - Lowest published toxic dose
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2600 mg/kg/65W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.11947Volume(issue)/page/year:
17,100,1963
** MUTATION DATA **
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 60 ug/disc
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year: 97,1,1982
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Bacillus subtilis
DOSE/DURATION
: 60 ng/disc
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year: 97,1,1982
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 12 ug/L
REFERENCE :
ARMKA7 Archiv fuer Mikrobiologie. (Berlin, Fed. Rep. Ger.) V.1-94,
1930-73. For publisher information, see AMICCW.
Volume(issue)/page/year:
81,1,1972
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 20 ug/L
REFERENCE :
AMACCQ Antimicrobial Agents and Chemotherapy. (American Soc. for
Microbiology, 1913 I St., NW, Washington, DC 20006) V.11972Volume(issue)/page/year: 17,572,1980
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 0.1 mg/m3 JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X3134
No. of Facilities: 151 (estimated)
No. of Industries: 1
No. of Occupations: 5
No. of Employees: 2695 (estimated)
No. of Female Employees: 1750 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
BENZYLPENICILLIN SODIUM
RTECS NUMBER
CHEMICAL NAME
acid,
CAS REGISTRY NUMBER
OTHER CAS REGISTRY NOS.
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
: XH9800000
: 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic
:
:
:
:
:
:
:
:
3,3-dimethyl-7-oxo-6-(2-phenyl acetamido)-,
monosodium salt
69-57-8
1406-09-3
199706
17
C16-H17-N2-O4-S.Na
356.40
T45 ANV ESTJ CMV1R& F1 F1 GVQ
Tumorigen
Drug
Mutagen
Reproductive Effector
Natural Product
SYNONYMS/TRADE NAMES :
* American penicillin
* Benzylpenicillinic acid sodium salt
* Benzylpenicillin sodium
* Benzylpenicillin sodium salt
* Crystapen
* Mycofarm
* Novocillin
* Pen-A-Brasive
* Penicillin-G, monosodium salt
* Penicillin G, sodium
* Penilaryn
* Sodium benzylpenicillin
* Sodium benzylpenicillin G
* Sodium benzylpenicillinate
* Sodium penicillin G
* Sodium penicillin II
* Veticillin
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 6916 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Gastrointestinal - other changes
REFERENCE :
AMPMAR Archives des Maladies Professionnelles de Medecine du Travail et
de
Securite Sociale. (SPPIF, B.P.22, F-41353 Vineuil, France)
1946Volume(issue)/page/year: 39,259,1978
V.7-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3020 mg/kg
TOXIC EFFECTS :
Cardiac - other changes
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 9,31,1959
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2900 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AACHAX Antimicrobial Agents and Chemotherapy (1961-70). (Ann Arbor, MI)
1961-70. For publisher information, see AMACCQ.
Volume(issue)/page/year:
-,863,1965
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ABANAE Antibiotics Annual. (New York, NY) 1953-60. For publisher
information, see AMACCQ. Volume(issue)/page/year: 3,540,1955/1956
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3314 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ABANAE Antibiotics Annual. (New York, NY) 1953-60. For publisher
information, see AMACCQ. Volume(issue)/page/year: 3,540,1955/1956
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 4750 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology.
(Nippon
Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40Volume(issue)/page/year:
55,23,1959
1944-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1500 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - changes in motor activity (specific assay)
Lungs, Thorax, or Respiration - other changes
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 9,31,1959
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 9,31,1959
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intracerebral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3800 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology.
(Nippon
Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
Yoshida, Sakyo-ku, Kyoto 606, Japan) V.401944Volume(issue)/page/year:
55,23,1959
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 150 mg/kg
TOXIC EFFECTS :
Gastrointestinal - other changes
Nutritional and Gross Metabolic - other changes
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 9,31,1959
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LDLo - Lowest published lethal dose
Intramuscular
Rodent - guinea pig
60 mg/kg
Details of toxic effects not reported other than lethal dose value
REFERENCE :
LBASAE Laboratory Animal Science. (American Assoc. for Laboratory Animal
Science, 210 N. Hammes Ave., Suite 205, Joliet, IL 60435) V.211971Volume(issue)/page/year: 30,524,1980
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1840 mg/kg/46W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Blood - lymphoma, including Hodgkin's disease
Tumorigenic - tumors at site of application
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.11947Volume(issue)/page/year:
15,85,1961
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1500 mg/kg
SEX/DURATION
: female 6-11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher
information, see AMBIEH. Volume(issue)/page/year: 18,815,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1500 mg/kg
SEX/DURATION
: female 1-5 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher
information, see AMBIEH. Volume(issue)/page/year: 18,815,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 30 mg/kg
SEX/DURATION
: female 14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
REFERENCE :
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France)
Volume(issue)/page/year: 158,528,1964
V.1-
1849-
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4380
No. of Facilities: 137 (estimated)
No. of Industries: 1
No. of Occupations: 5
No. of Employees: 7315 (estimated)
No. of Female Employees: 5985 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
BENZYLPIPERIDINE (4-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
SYNONYMS/TRADE NAMES :
* 4-Benzylpiperidine
:
:
:
:
:
:
:
:
:
:
TM4728000
Piperidine, 4-benzyl31252-42-3
0132339
5-20-06-00439 (Beilstein Handbook Reference)
199701
2
C12-H17-N
175.30
T6MTJ D1R
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 56 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD
21010)
Volume(issue)/page/year: NX#01587
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BENZYLTRIETHYLAMMONIUM CHLORIDE
RTECS NUMBER
: BO8275000
CHEMICAL NAME
: Ammonium, benzyltriethyl-, chloride
CAS REGISTRY NUMBER
: 56-37-1
LAST UPDATED
: 199709
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C13-H22-N.Cl
MOLECULAR WEIGHT
: 227.81
WISWESSER LINE NOTATION : 2K2&2&1R &G
SYNONYMS/TRADE NAMES :
* Benzenemethanaminium, N,N,N-triethyl-, chloride
* Benzyltriethylammonium chloride
* TEBA
* TEBAC
* N,N,N-Triethylbenzenemethanaminium chloride
* Triethylbenzylammonium chloride
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2219 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Gastrointestinal - changes in structure or function of salivary glands
Skin and Appendages - hair
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of
Toxicology,
Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)
V.11990- Volume(issue)/page/year: 15(Suppl 1),S61,1996
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 18 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD
21010)
Volume(issue)/page/year: NX#01867
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BENZYLTRIMETHYLAMMONIUM CHLORIDE
RTECS NUMBER
: BO8400000
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
Ammonium, benzyltrimethyl-, chloride
56-93-9
199907
8
C10-H16-N.Cl
185.72
1K1&1&1R &G
Agricultural Chemical
Tumorigen
SYNONYMS/TRADE NAMES :
* Benzenemethanaminium, N,N,N-trimethyl-, chloride
* Benzyltrimethylammonium chloride
* BTM
* Tmbac
* N,N,N-Trimethylbenzenemethanaminium chloride
* Trimethylbenzylammonium chloride
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCNSA6 National Academy of Sciences, National Research Council,
Chemical-Biological Coordination Center, Review. (Washington, DC)
Volume(issue)/page/year: 5,39,1953
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical
Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.501961Volume(issue)/page/year: 69,327,1980
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83392
No. of Facilities: 3855 (estimated)
No. of Industries: 39
No. of Occupations: 51
No. of Employees: 32889 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 83392
No. of Facilities: 122 (estimated)
No. of Industries: 4
No. of Occupations: 3
No. of Employees: 5002 (estimated)
No. of Female Employees: 2721 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(e) Risk Notification, 8EHQ-1292-8625
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NTP Carcinogenesis studies; test completed (post peer review), May 1999
BENZYLTRIMETHYLAMMONIUM IODIDE
RTECS NUMBER
: BO8585000
CHEMICAL NAME
: Ammonium, benzyltrimethyl-, iodide
CAS REGISTRY NUMBER
: 4525-46-6
LAST UPDATED
: 199701
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C10-H16-N.I
MOLECULAR WEIGHT
: 277.17
WISWESSER LINE NOTATION : 1K1&1&1R &I
SYNONYMS/TRADE NAMES :
* Ammonium, trimethylbenzyl-, iodide
* Benzenemethanaminium, N,N,N-trimethyl-, iodide
* Benzyldimethylamine methiodide
* Benzyl-trimethylammonium iodide
* Phenmethyl-trimethylammonium iodide
* N,N,N-Trimethylbenzenemethanaminium iodide
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 41 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
UCPHAQ University of California, Berkeley, Publications in Pharmacology.
(Berkeley, CA) V.1-3, 1938-57. Discontinued. Volume(issue)/page/year:
2,161,1944
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 5600 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals.
21010)
Volume(issue)/page/year: NX#00844
(Aberdeen Proving Ground, MD
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BENZ[B]ANTHRACENE
RTECS NUMBER
: QI7605000
CHEMICAL NAME
: Naphthacene
CAS REGISTRY NUMBER
: 92-24-0
LAST UPDATED
: 199706
DATA ITEMS CITED
: 4
MOLECULAR FORMULA
: C18-H12
MOLECULAR WEIGHT
: 228.30
WISWESSER LINE NOTATION : L E6 C666J
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Benz(b)anthracene
* 2,3-Benzanthracene
* 2,3-Benzanthrene
* Chrysogen
* Rubene
* Tetracene (hydrocarbon)
*** HEALTH HAZARD DATA ***
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 25 ug/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
207,205,1988
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 500 umol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 3,11,1981
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - T1255
No. of Facilities: 11 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 32 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BERYLLIUM
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
DS1750000
Beryllium
7440-41-7
199907
63
Be
9.01
BE
Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* Beryllium-9
* Beryllium
* Glucinium
* Glucinum
* RCRA waste number P015
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 496 ug/kg
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), zonal
REFERENCE :
LAINAW Laboratory Investigation. (Williams & Wilkins Co., 428 E. Preston
St., Baltimore, MD 21202) V.11952- Volume(issue)/page/year:
15,176,1966
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intratracheal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 13 mg/kg
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Lungs, Thorax, or Respiration - bronchiogenic carcinoma
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11967- Volume(issue)/page/year: 21,63,1980
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: TDLo - Lowest published toxic dose
: Intravenous
: Rodent - rabbit
DOSE/DURATION
: 20 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Musculoskeletal - tumors
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.11823Volume(issue)/page/year: 1,463,1950
** MUTATION DATA **
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 30 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
89,95,1981
TYPE OF TEST
: DNA inhibition
ROUTE OF EXPOSURE
: Intravenous
TEST SYSTEM
: Non-mammalian species
DOSE/DURATION
: 30 umol/kg
REFERENCE :
PHMCAA Pharmacologist. (American Soc. for Pharmacology and Experimental
Therapeutics, 9650 Rockville Pike, Bethesda, MD 20014) V.11959Volume(issue)/page/year: 12,298,1970
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Human HeLa cell
DOSE/DURATION
: 30 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
89,95,1981
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Rodent - mouse Ascites tumor
DOSE/DURATION
: 30 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
89,95,1981
*** REVIEWS ***
ACGIH TLV-SUSPECTED HUMAN CARCINOGEN
85INA8 "Documentation of the Threshold Limit Values and Biological
Exposure
Indices," 5th ed., Cincinnati, OH, American Conference of Governmental
Industrial Hygienists, Inc., 1986 Volume(issue)/page/year: 6,1/BEI,1997
ACGIH TLV-Suspected human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 0.002 mg/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 1,17,1972
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 23,143,1980
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 58,41,1993
IARC Cancer Review:Human Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 23,143,1980
IARC Cancer Review:Human Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 58,41,1993
IARC Cancer Review:Group 1
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 58,41,1993
TOXICOLOGY REVIEW
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000
Corporate
Blvd., NW, Boca Raton, FL 33431) V.11971- Volume(issue)/page/year:
1,235,1972
TOXICOLOGY REVIEW
85CVA2 "Oncology 1970, Proceedings of the Tenth International Cancer
Congress," Chicago, Year Book Medical Pub., 1971
Volume(issue)/page/year:
5,63,1970
TOXICOLOGY REVIEW
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81.
publisher
information, see JTCTDW. Volume(issue)/page/year: 6,497,1973
TOXICOLOGY REVIEW
AEMBAP Advances in Experimental Medicine and Biology.
Corp.,
233 Spring St., New York, NY 10013) V.11967Volume(issue)/page/year:
40,239,1973
TOXICOLOGY REVIEW
AJMEAZ American Journal of Medicine.
For
(Plenum Pub.
(Technical Pub., 875 Third Ave.,
New
York, NY 10022) V.1-
1946-
Volume(issue)/page/year: 38,409,1965
TOXICOLOGY REVIEW
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: CONF-691001
TOXICOLOGY REVIEW
AMTODM Advances in Modern Toxicology. (John Wiley & Sons, Inc., 605
Third
Ave., New York, NY 10016) V.1, 1976-79. Discontinued.
Volume(issue)/page/year: 3,209,1977
TOXICOLOGY REVIEW
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.11895- Volume(issue)/page/year:
201,298,1978
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.002 mg/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,24,1971
OSHA PEL (Gen Indu):8H TWA 0.002 mg(Be)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 0.002 mg(Be)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 0.002 mg(Be)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 0.002 mg(Be)/m3
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
41,50-204.50,1994
(U.S. Government Printing Office,
Volume(issue)/page/year:
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 0.002 mg/m3 JAN 1993
OEL-AUSTRIA: Carcinogen, JAN1999
OEL-AUSTRALIA:TWA 0.002 mg/m3;Carcinogen JAN 1993
OEL-BELGIUM:TWA 0.002 mg/m3;Carcinogen JAN 1993
OEL-DENMARK: TWA 0.001 mg/m3, JAN1999
OEL-FINLAND:TWA 0.002 mg/m3;STEL 0.006 mg/m3;Carcinogen JAN 1993
OEL-JAPAN: OEL 0.002 mg/m3, 2A Carcinogen, JAN1999
OEL-GERMANY;Carcinogen JAN 1993
OEL-HUNGARY:STEL 0.001 mg/m3;Carcinogen JAN 1993
OEL-POLAND: MAC(TWA) 0.001 mg/m3, MAC(STEL) 0.003 mg/m3, JAN1999
OEL-INDIA:TWA 0.002 mg/m3;Carcinogen JAN 1993
OEL-JAPAN:TWA 0.002 mg/m3;Carcinogen JAN 1993
OEL-THE NETHERLANDS:TWA 0.002 mg/m3 JAN 1993
OEL-THE PHILIPPINES:TWA 0.002 mg/m3 JAN 1993
OEL-RUSSIA:STEL 0.001 mg/m3;Carcinogen JAN 1993
OEL-SWEDEN:TWA 0.002 mg/m3;Carcinogen JAN 1993
OEL-SWITZERLAND:TWA 0.002 mg/m3;Carcinogen JAN 1993
OEL-THAILAND:TWA 0.002 mg/m3;STEL 0.005 mg/m3 JAN 1993
OEL-TURKEY:TWA 0.002 mg/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.002 mg/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO BERYLLIUM-air:CA not to exceed 0.0005 mg(Be)/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 11770
No. of Facilities: 344 (estimated)
No. of Industries: 8
No. of Occupations: 17
No. of Employees: 10510 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 11770
No. of Facilities: 421 (estimated)
No. of Industries: 22
No. of Occupations: 29
No. of Employees: 13938 (estimated)
No. of Female Employees: 739 (estimated)
*** STATUS IN U.S. ***
ATSDR TOXICOLOGY PROFILE
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB/89/148233/AS
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Beryllium and compounds, as Be, 7102
NIOSH Analytical Method, 1994: Elements by ICP, 7300
NTP 8th Annual Report on Carcinogens, 1998:Reasonably Anticipated to be
Human Carcinogen
BERYLLIUM CARBONATE
RTECS NUMBER
: DS2400000
CHEMICAL NAME
: Beryllium carbonate (1:1)
CAS REGISTRY NUMBER
: 13106-47-3
LAST UPDATED
: 199907
DATA ITEMS CITED
: 32
MOLECULAR FORMULA
: C-O3.Be
MOLECULAR WEIGHT
: 69.02
WISWESSER LINE NOTATION : BE C-O3
SYNONYMS/TRADE NAMES :
* Carbonic acid beryllium salt (1:1)
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed.
Rep.
Ger.) V.1-5, 1975-76. Discontinued. Volume(issue)/page/year: 1,1,1975
*** REVIEWS ***
ACGIH TLV-SUSPECTED HUMAN CARCINOGEN
85INA8 "Documentation of the Threshold Limit Values and Biological
Exposure
Indices," 5th ed., Cincinnati, OH, American Conference of Governmental
Industrial Hygienists, Inc., 1986 Volume(issue)/page/year: 6,1/BEI,1997
ACGIH TLV-TWA 0.002 mg(Be)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-Suspected human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
OSHA PEL (Gen Indu):8H TWA 0.002 mg(Be)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 0.002 mg(Be)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 0.002 mg(Be)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 0.002 mg(Be)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 0.002 mg(Be)/m3 JAN 1993
OEL-AUSTRIA: Carcinogen, JAN1999
OEL-AUSTRALIA:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993
OEL-BELGIUM:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993
OEL-DENMARK: TWA 0.001 mg(Be)/m3, JAN1999
OEL-FINLAND:TWA 0.002 mg(Be)/m3;STEL 0.006 mg(Be)/m3;Carcinogen JAN 1993
OEL-JAPAN: OEL 0.002 mg(Be)/m3, 2A Carcinogen, JAN1999
OEL-GERMANY;Carcinogen JAN 1993
OEL-HUNGARY:STEL 0.001 mg(Be)/m3;Carcinogen JAN 1993
OEL-POLAND: MAC(TWA) 0.001 mg(Be)/m3, MAC(STEL) 0.003 mg(Be)/m3, JAN1999
OEL-INDIA:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993
OEL-JAPAN:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993
OEL-THE NETHERLANDS:TWA 0.002 mg(Be)/m3 JAN 1993
OEL-THE PHILIPPINES:TWA 0.002 mg(Be)/m3 JAN 1993
OEL-RUSSIA:STEL 0.001 mg(Be)/m3;Carcinogen JAN 1993
OEL-SWEDEN:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993
OEL-SWITZERLAND:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993
OEL-THAILAND:TWA 0.002 mg(Be)/m3;STEL 0.005 mg(Be)/m3 JAN 1993
OEL-TURKEY:TWA 0.002 mg(Be)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.002 mg(Be)/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO BERYLLIUM-air:CA not to exceed 0.0005 mg(Be)/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BERYLLIUM OXIDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
DS4025000
Beryllium oxide
1304-56-9
199907
51
Be-O
25.01
BE O
Tumorigen
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Beryllia
* Beryllium monoxide
* Thermalox
*** HEALTH HAZARD DATA ***
** TUMORIGENIC DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 28 mg/m3/17W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42,
1949-73.
For publisher information, see IOHSA5. Volume(issue)/page/year:
40,23,1971
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intratracheal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 75 mg/kg/15W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
FKIZA4 Fukuoka Igaku Zasshi. (c/o Kyushu Daigaku Igakubu, Tatekasu,
Fukuoka-shi, Fukuoka, Japan) V.331940- Volume(issue)/page/year:
71,19,1980
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 17 mg/m3/5H/D/48W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Musculoskeletal - tumors
REFERENCE :
AMPLAO AMA Archives of Pathology. (Chicago, IL) V.50(4)-69, 1950-60.
For
publisher information, see APLMAS. Volume(issue)/page/year: 51,473,1951
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/kg/6W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Musculoskeletal - tumors
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for
Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
Volume(issue)/page/year: 5,221,1946
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Implant
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 10 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Musculoskeletal - tumors
REFERENCE :
ARPAAQ Archives of Pathology. (Chicago, IL) V.5(3)-50(3), 1928-50;
V.70-99, 1960-75. For publisher information, see APLMAS.
Volume(issue)/page/year: 88,89,1969
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/kg/48W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Musculoskeletal - tumors
REFERENCE :
PEXTAR Progress in Experimental Tumor Research. (S. Karger AG, Postfach
CH-4009 Basel, Switzerland) V.11960- Volume(issue)/page/year:
2,203,1961
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Intratracheal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 169 mg/kg/2W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - chronic pulmonary edema
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - multiple enzyme effects
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21,
1955-60.
For publisher information, see AEHLAU. Volume(issue)/page/year:
19,190,1959
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 625 mg/kg/25W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Musculoskeletal - tumors
REFERENCE :
AMSHAR Acta Morphologica Academiae Scientiarum Hungaricae. (Budapest,
Hungary) V.1-30, 1951-82. Volume(issue)/page/year: 25,99,1977
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Intratracheal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 79 mg/kg/15W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon
Sangyo
Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo
160,
Japan) V.11959- Volume(issue)/page/year: 20,230,1978
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intratracheal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 139 mg/kg
SEX/DURATION
: female 3 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora
lutea)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 51(8),44,1986
*** REVIEWS ***
ACGIH TLV-SUSPECTED HUMAN CARCINOGEN
85INA8 "Documentation of the Threshold Limit Values and Biological
Exposure
Indices," 5th ed., Cincinnati, OH, American Conference of Governmental
Industrial Hygienists, Inc., 1986 Volume(issue)/page/year: 6,1/BEI,1997
ACGIH TLV-TWA 0.002 mg(Be)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-Suspected human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 1,17,1972
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 23,143,1980
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 58,41,1993
IARC Cancer Review:Human Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 58,41,1993
IARC Cancer Review:Group 1
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 58,41,1993
TOXICOLOGY REVIEW
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81.
publisher
information, see JTCTDW. Volume(issue)/page/year: 6,497,1973
TOXICOLOGY REVIEW
FCTXAV Food and Cosmetics Toxicology.
(London, UK)
For
V.1-19, 1963-81.
For
publisher information, see FCTOD7.
Volume(issue)/page/year: 9,105,1971
*** U.S. STANDARDS AND REGULATIONS ***
OSHA PEL (Gen Indu):8H TWA 0.002 mg(Be)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 0.002 mg(Be)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 0.002 mg(Be)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 0.002 mg(Be)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 0.002 mg(Be)/m3 JAN 1993
OEL-AUSTRIA: Carcinogen, JAN1999
OEL-AUSTRALIA:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993
OEL-BELGIUM:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993
OEL-DENMARK: TWA 0.001 mg(Be)/m3, JAN1999
OEL-FINLAND:TWA 0.002 mg(Be)/m3;STEL 0.006 mg(Be)/m3;Carcinogen JAN 1993
OEL-JAPAN: OEL 0.002 mg(Be)/m3, 2A Carcinogen, JAN1999
OEL-GERMANY;Carcinogen JAN 1993
OEL-HUNGARY:STEL 0.001 mg(Be)/m3;Carcinogen JAN 1993
OEL-POLAND: MAC(TWA) 0.001 mg(Be)/m3, STEL 0.003 mg(Be)/m3, JAN1999
OEL-INDIA:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993
OEL-JAPAN:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993
OEL-THE NETHERLANDS:TWA 0.002 mg(Be)/m3 JAN 1993
OEL-THE PHILIPPINES:TWA 0.002 mg(Be)/m3 JAN 1993
OEL-RUSSIA:STEL 0.001 mg(Be)/m3;Carcinogen JAN 1993
OEL-SWEDEN:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993
OEL-SWITZERLAND:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993
OEL-THAILAND:TWA 0.002 mg(Be)/m3;STEL 0.005 mg(Be)/m3 JAN 1993
OEL-TURKEY:TWA 0.002 mg(Be)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.002 mg(Be)/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO BERYLLIUM-air:CA not to exceed 0.0005 mg(Be)/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X3577
No. of Facilities: 66 (estimated)
No. of Industries: 6
No. of Occupations: 9
No. of Employees: 4305 (estimated)
No. of Female Employees: 849 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NTP 8th Annual Report on Carcinogens, 1998:Reasonably Anticipated to be
Human Carcinogen
BERYLLIUM SULFATE TETRAHYDRATE
RTECS NUMBER
: DS5000000
CHEMICAL NAME
: Beryllium sulfate, tetrahydrate (1:1:4)
CAS REGISTRY NUMBER
: 7787-56-6
LAST UPDATED
: 199907
DATA ITEMS CITED
: 57
MOLECULAR FORMULA
: O4-S.Be.4H2-O
MOLECULAR WEIGHT
: 177.15
WISWESSER LINE NOTATION : BE S-O4 &QH 4
COMPOUND DESCRIPTOR
: Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* Beryllium sulphate tetrahydrate
* Sulfuric acid, beryllium salt (1:1), tetrahydrate
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LD50 - Lethal dose, 50 percent kill
: Intravenous
: Rodent - rat
DOSE/DURATION
: 3850 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
82,344,1986
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 41 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
63,461,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 4971 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
24,497,1973
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Bird - chicken
DOSE/DURATION
: 2500 ug/kg
TOXIC EFFECTS :
Behavioral - fluid intake
Skin and Appendages - hair
REFERENCE :
AGEFAB Archiv fuer Gefluegelkunde. (Verlag Eugen Ulmer, Postfach 700561,
D-7000 Stuttgart 70, Fed. Rep. Ger.) V.11927Volume(issue)/page/year:
42,225,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Bird - chicken
DOSE/DURATION
: 470 ug/kg
TOXIC EFFECTS :
Behavioral - fluid intake
Skin and Appendages - hair
REFERENCE :
AGEFAB Archiv fuer Gefluegelkunde. (Verlag Eugen Ulmer, Postfach 700561,
D-7000 Stuttgart 70, Fed. Rep. Ger.) V.11927Volume(issue)/page/year:
42,225,1978
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 90 mg/m3/6H/2W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - chronic pulmonary edema
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
Related to Chronic Data - death
REFERENCE :
XETIAS U.S. Atomic Energy Commission, AECD Reports. (U.S. Atomic Energy
Commission, Technical Information Division, AEC, Oak Ridge, Tenn.)
Volume(issue)/page/year: AECD-2102,1948
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 90 mg/m3/6H/2W-I
TOXIC EFFECTS :
Behavioral - irritability
Liver - other changes
Related to Chronic Data - death
REFERENCE :
XETIAS U.S. Atomic Energy Commission, AECD Reports. (U.S. Atomic Energy
Commission, Technical Information Division, AEC, Oak Ridge, Tenn.)
Volume(issue)/page/year: AECD-2102,1948
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 90 mg/m3/6H/2W-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - corneal damage
Blood - changes in leukocyte (WBC) count
Skin and Appendages - dermatitis, irritative (after systemic exposure)
REFERENCE :
XETIAS U.S. Atomic Energy Commission, AECD Reports. (U.S. Atomic Energy
Commission, Technical Information Division, AEC, Oak Ridge, Tenn.)
Volume(issue)/page/year: AECD-2102,1948
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 90 mg/m3/6H/2W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - chronic pulmonary edema
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
Blood - changes in leukocyte (WBC) count
REFERENCE :
XETIAS U.S. Atomic Energy Commission, AECD Reports. (U.S. Atomic Energy
Commission, Technical Information Division, AEC, Oak Ridge, Tenn.)
Volume(issue)/page/year: AECD-2102,1948
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TCLo - Lowest published toxic concentration
Inhalation
Rodent - guinea pig
90 mg/m3/6H/2W-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - conjunctive irritation
REFERENCE :
XETIAS U.S. Atomic Energy Commission, AECD Reports. (U.S. Atomic Energy
Commission, Technical Information Division, AEC, Oak Ridge, Tenn.)
Volume(issue)/page/year: AECD-2102,1948
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - hamster
DOSE/DURATION
: 90 mg/m3/6H/2W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - chronic pulmonary edema
Blood - hemorrhage
Related to Chronic Data - death
REFERENCE :
XETIAS U.S. Atomic Energy Commission, AECD Reports. (U.S. Atomic Energy
Commission, Technical Information Division, AEC, Oak Ridge, Tenn.)
Volume(issue)/page/year: AECD-2102,1948
** TUMORIGENIC DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 668 ug/m3/40W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
27,439,1967
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 3300 ng/plate
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 6(Suppl
2),1,1984
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 5 mg/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 3,597,1981
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 1 mg/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 3,597,1981
TYPE OF TEST
: Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE
: Parenteral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 30 umol/kg
REFERENCE :
AEHLAU Archives of Environmental Health.
St.,
NW, Washington, DC 20016) V.1196026,48,1973
(Heldref Pub., 4000 Albemarle
Volume(issue)/page/year:
TYPE OF TEST
: Morphological transformation
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 312 ug/L
REFERENCE :
IJCNAW International Journal of Cancer. (International Union Against
Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.11966Volume(issue)/page/year: 19,642,1977
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 5 mg/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 3,597,1981
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Embryo
DOSE/DURATION
: 1 mg/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 3,597,1981
*** REVIEWS ***
ACGIH TLV-SUSPECTED HUMAN CARCINOGEN
85INA8 "Documentation of the Threshold Limit Values and Biological
Exposure
Indices," 5th ed., Cincinnati, OH, American Conference of Governmental
Industrial Hygienists, Inc., 1986 Volume(issue)/page/year: 6,1/BEI,1997
ACGIH TLV-TWA 0.002 mg(Be)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-Suspected human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 1,17,1972
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 23,143,1980
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 58,41,1993
IARC Cancer Review:Human Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 58,41,1993
IARC Cancer Review:Group 1
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 58,41,1993
*** U.S. STANDARDS AND REGULATIONS ***
OSHA PEL (Gen Indu):8H TWA 0.002 mg(Be)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 0.002 mg(Be)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 0.002 mg(Be)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 0.002 mg(Be)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 0.002 mg(Be)/m3 JAN 1993
OEL-AUSTRIA: Carcinogen, JAN1999
OEL-AUSTRALIA:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993
OEL-BELGIUM:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993
OEL-DENMARK: TWA 0.001 mg(Be)/m3, JAN1999
OEL-FINLAND:TWA 0.002 mg(Be)/m3;STEL 0.006 mg(Be)/m3;Carcinogen JAN 1993
OEL-JAPAN: OEL 0.002 mg(Be)/m3, 2A Carcinogen, JAN1999
OEL-GERMANY;Carcinogen JAN 1993
OEL-HUNGARY:STEL 0.001 mg(Be)/m3;Carcinogen JAN 1993
OEL-POLAND: MAC(TWA) 0.001 mg(Be)/m3, STEL 0.003 mg(Be)/m3, JAN1999
OEL-INDIA:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993
OEL-JAPAN:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993
OEL-THE NETHERLANDS:TWA 0.002 mg(Be)/m3 JAN 1993
OEL-THE PHILIPPINES:TWA 0.002 mg(Be)/m3 JAN 1993
OEL-RUSSIA:STEL 0.001 mg(Be)/m3;Carcinogen JAN 1993
OEL-SWEDEN:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993
OEL-SWITZERLAND:TWA 0.002 mg(Be)/m3;Carcinogen JAN 1993
OEL-THAILAND:TWA 0.002 mg(Be)/m3;STEL 0.005 mg(Be)/m3 JAN 1993
OEL-TURKEY:TWA 0.002 mg(Be)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.002 mg(Be)/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO BERYLLIUM-air:CA not to exceed 0.0005 mg(Be)/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X6326
No. of Facilities: 7 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 1822 (estimated)
No. of Female Employees: 230 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: SHE-clonal assay
NTP 8th Annual Report on Carcinogens, 1998:Reasonably Anticipated to be
Human Carcinogen
BES
RTECS NUMBER
: KI7363500
CHEMICAL NAME
: Ethanesulfonic acid, 2-(bis(2-hydroxyethyl)amino)CAS REGISTRY NUMBER
: 10191-18-1
BEILSTEIN REFERENCE NO. : 1781572
REFERENCE
: 4-04-00-03290 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C6-H15-N-O5-S
MOLECULAR WEIGHT
: 213.28
SYNONYMS/TRADE NAMES :
* BES
* BES (buffering agent)
* 2-(Bis(2-hydroxyethyl)amino)ethanesulfonic acid
* Taurine, N,N-bis(2-hydroxyethyl)*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - quail
DOSE/DURATION
: >316 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1
E.
First St., Duluth, MN 55802) V.11977- Volume(issue)/page/year:
6,149,1982
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X2451
No. of Facilities: 48 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 598 (estimated)
No. of Female Employees: 456 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BETAINE
RTECS NUMBER
: DS5900000
CHEMICAL NAME
: Betaine
CAS REGISTRY NUMBER
: 107-43-7
OTHER CAS REGISTRY NOS. : 11042-12-9
BEILSTEIN REFERENCE NO. : 3537113
REFERENCE
: 4-04-00-02369 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C5-H11-N-O2
MOLECULAR WEIGHT
: 117.17
WISWESSER LINE NOTATION : QV1K1&1&1 &Q
COMPOUND DESCRIPTOR
: Natural Product
SYNONYMS/TRADE NAMES :
* Abromine
* (Carboxymethyl)trimethylammonium hydroxide, inner salt
* alpha-Earleine
* Glycine betaine
* Glycocoll betaine
* Glycylbetaine
* Glykokollbetain
* Jortaine
* Loramine AMB 13
* Lycine
* Oxyneurine
* Rubrine C
* Trimethylglycine
* Trimethylglycocoll
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 10800 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - fluid intake
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.)
V.1-41,
1958-82. For publisher information, see BBIADT. Volume(issue)/page/year:
3,28,1959
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 830 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MPHEAE Medicina et Pharmacologia Experimentalis. (Basel, Switzerland)
V.12-17, 1965-67. For publisher information, see PHMGBN.
Volume(issue)/page/year: 16,529,1967
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BETAINE HYDRAZIDE HYDROCHLORIDE
RTECS NUMBER
: CP3150000
CHEMICAL NAME
: Ammonium, (carboxymethyl)trimethyl-, chloride,
hydrazide
CAS REGISTRY NUMBER
: 123-46-6
LAST UPDATED
: 199701
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C5-H14-N3-O.Cl
MOLECULAR WEIGHT
: 167.67
WISWESSER LINE NOTATION : ZMV1K1&1&1 &G
SYNONYMS/TRADE NAMES :
* Betaine hydrazide hydrochloride
* (Carboxymethyl)trimethylammonium chloride hydrazide
* Ethanaminium, 2-hydrazino-N,N,N-trimethyl-2-oxo-, chloride
* Girard T reagent
* Girard's Reagent T
* Girard reagent T
* Trimethylacethydrazide ammonium chloride
* Trimethylaminoacetohydrazide chloride
* Trimethylammonium acetyl hydrazide chloride
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCNSA6 National Academy of Sciences, National Research Council,
Chemical-Biological Coordination Center, Review. (Washington, DC)
Volume(issue)/page/year: 5,25,1953
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BETAINE HYDROCHLORIDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
: BP3136000
: Ammonium, (carboxymethyl)trimethyl-, chloride
: 590-46-5
OTHER CAS REGISTRY NOS. : 11042-13-0
LAST UPDATED
: 199709
DATA ITEMS CITED
: 4
MOLECULAR FORMULA
: C5-H12-N-O2.Cl
MOLECULAR WEIGHT
: 153.63
SYNONYMS/TRADE NAMES :
* Achylin
* Acidin
* Acidine
* Acidogeno
* Acidol
* Acidol hydrochloride
* Acinorm
* Acipepsol
* Aciventral forte
* Betaine chloride
* Betaine, hydrochloride
* (Carboxymethyl)trimethylammonium chloride
* Glycine betaine hydrochloride
* Glycocoll betain hydrochloride
* Glykokollbetain-chlorid
* Methanaminium, 1-carboxy-N,N,N-trimethyl-, chloride
* Pluchine
* Rubraine hydrochloride
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 8 gm/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - fluid intake
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.)
V.1-41,
1958-82. For publisher information, see BBIADT. Volume(issue)/page/year:
3,28,1959
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 80382
No. of Facilities: 112 (estimated)
No. of Industries: 3
No. of Occupations: 10
No. of Employees: 3807 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 80382
No. of Facilities: 204 (estimated)
No. of Industries: 11
No. of Occupations: 23
No. of Employees: 4634 (estimated)
No. of Female Employees: 2460 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BICINE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
SYNONYMS/TRADE NAMES :
* N,N-Dihydroxyethyl
:
:
:
:
:
:
:
:
:
:
MB9700000
Glycine, N,N-dihydroxyethyl150-25-4
1769362
4-04-00-02390 (Beilstein Handbook Reference)
199701
3
C6-H13-N-O4
163.20
QV1N2Q2Q
glycine
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1540 mg/kg
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
REFERENCE :
REPMBN Revue d'Epidemiologie, Medecine Sociale et Sante Publique.
(Masson
Editeur, 120 Blvd. Saint-Germain, F-75280 Paris Cedex O6, France) V.11953- Volume(issue)/page/year: 10,391,1962
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X9723
No. of Facilities: 130 (estimated)
No. of Industries: 1
No. of Occupations: 3
No. of Employees: 1828 (estimated)
No. of Female Employees: 1552 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BICYCLOHEPTADIENE
RTECS NUMBER
: RB6535000
CHEMICAL NAME
: Norbornadiene
CAS REGISTRY NUMBER
: 121-46-0
LAST UPDATED
: 199710
DATA ITEMS CITED
: 9
MOLECULAR FORMULA
: C7-H8
MOLECULAR WEIGHT
: 92.15
WISWESSER LINE NOTATION : L55 A CU FUTJ
SYNONYMS/TRADE NAMES :
* Bicyclo(2.2.1)heptadiene
* 2,5-Norbornadiene
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 14100 ppm/8H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon
Rd.,
San Romon, CA 94583) Volume(issue)/page/year: -,1,1961
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 890 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon
Rd.,
San Romon, CA 94583) Volume(issue)/page/year: -,1,1961
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3850 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon
Rd.,
San Romon, CA 94583) Volume(issue)/page/year: -,1,1961
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 27700 ppm/30M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon
Rd.,
San Romon, CA 94583)
Volume(issue)/page/year: -,1,1961
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 56 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD
21010)
Volume(issue)/page/year: NX#04158
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 1 mg/m3 JAN 1993
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
BINAPHTHOL (1,1:2-)
RTECS NUMBER
: DU3106000
CHEMICAL NAME
: (1,1'-Binaphthalene)-2,2'-diol
CAS REGISTRY NUMBER
: 602-09-5
BEILSTEIN REFERENCE NO. : 0997518
REFERENCE
: 4-06-00-07020 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C20-H14-O2
MOLECULAR WEIGHT
: 286.34
SYNONYMS/TRADE NAMES :
* beta-Binaphthol
* 1,1'-Bi-2-naphthol
* Bis-beta-naphthol
* 2,2'-Dihydroxybinaphthalene
* 2,2'-Dihydroxydinaphthyl
* 2,2'-Dinaphthol
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 42 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AECTCV Archives of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
070944) V.11973- Volume(issue)/page/year: 14,111,1985
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BIOTIN (D-)
RTECS NUMBER
CHEMICAL NAME
6a-alpha))CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
* Bioepiderm
* Bios II
* Biotin
* (+)-Biotin
* d-Biotin
* D-Biotin
* D-(+)-Biotin
* Coenzyme R
* Factor S
* Factor S (vitamin)
* Vitamin B7
* Vitamin H
: XJ9088200
: 1H-Thieno(3,4-d)imidazole-4-pentanoic acid,
hexahydro-2-oxo-, (3aS-(3a-alpha,4-beta,
:
:
:
:
:
:
:
58-85-5
199706
7
C10-H16-N2-O3-S
244.34
T55 BMVM GSTJ H4VQ
Reproductive Effector
*** HEALTH HAZARD DATA ***
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 200 mg/kg
SEX/DURATION
: female 14-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
(e.g., placenta, umbilical cord)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
JNSVA5 Journal of Nutritional Science and Vitaminology. (Business Center
for Academic Soc. Japan, 2-4-16 Yayoi, Bunkyo-ku, Tokyo 113, Japan)
V.19-
1973-
Volume(issue)/page/year: 22,181,1976
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 100 mg/kg
SEX/DURATION
: male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter;
measured
before birth)
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
(e.g., placenta, umbilical cord)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
CUSCAM Current Science. (Current Science Assoc., Sadashivanagar P.O.,
Bangalore 560 080, India) V.11932- Volume(issue)/page/year:
42,613,1973
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 200 mg/kg
SEX/DURATION
: female 1-2 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
JNSVA5 Journal of Nutritional Science and Vitaminology. (Business Center
for Academic Soc. Japan, 2-4-16 Yayoi, Bunkyo-ku, Tokyo 113, Japan)
V.191973- Volume(issue)/page/year: 21,89,1975
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 17 mg/kg
SEX/DURATION
: female 1-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects
REFERENCE :
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
Switzerland) V.11945- Volume(issue)/page/year: 52,149,1996
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 80381
No. of Facilities: 129 (estimated)
No. of Industries: 2
No. of Occupations: 8
No. of Employees: 8306 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 80381
No. of Facilities: 1674 (estimated)
No. of Industries: 9
No. of Occupations: 41
No. of Employees: 46583 (estimated)
No. of Female Employees: 22672 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BIPHENOL (4,4'-)
RTECS NUMBER
: DV4725000
CHEMICAL NAME
: 4,4'-Biphenyldiol
CAS REGISTRY NUMBER
: 92-88-6
BEILSTEIN REFERENCE NO. : 1908886
REFERENCE
: 4-06-00-06651 (Beilstein Handbook Reference)
LAST UPDATED
: 199806
DATA ITEMS CITED
: 9
MOLECULAR FORMULA
: C12-H10-O2
MOLECULAR WEIGHT
: 186.22
WISWESSER LINE NOTATION : QR DR DQ
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Antioxidant DOD
* ASM DOD
* p,p'-Biphenol
* 4,4'-Biphenol
* (1,1'-Biphenyl)-4,4'-diol
* 4,4'-Bisphenol
* p,p'-Dihydroxybiphenyl
* 4,4'-Dihydroxybiphenyl
* p-Dihydroxydiphenyl
* 4,4'-dihydroxydiphenyl
* p,p'-Diphenol
* 4,4'-Diphenol
* USAF DO-30
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4920 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
Liver - other changes
Kidney, Ureter, Bladder - other changes
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0534530
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LD50 - Lethal dose, 50 percent kill
: Intraperitoneal
: Rodent - mouse
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1780 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
28,313,1974
** MUTATION DATA **
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 100 nmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
45,2471,1985
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 5 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
45,2471,1985
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 40 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
208,61,1988
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
BIPHENOL (O,O'-)
RTECS NUMBER
: DV4200000
CHEMICAL NAME
: 2,2'-Biphenyldiol
CAS REGISTRY NUMBER
: 1806-29-7
BEILSTEIN REFERENCE NO. : 1638363
REFERENCE
: 4-06-00-06645 (Beilstein Handbook Reference)
LAST UPDATED
: 199710
DATA ITEMS CITED
: 8
MOLECULAR FORMULA
: C12-H10-O2
MOLECULAR WEIGHT
: 186.22
WISWESSER LINE NOTATION : QR BR BQ
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* o,o'-Biphenol
* 2,2'-Biphenol
* 2,2'-Dihydroxybiphenyl
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD691-490
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 56 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD
21010)
Volume(issue)/page/year: NX#07870
** MUTATION DATA **
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 5 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
45,2471,1985
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
: Sister chromatid exchange
: Human Lymphocyte
: 300 umol/L
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
45,2471,1985
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 40 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
208,61,1988
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
BIPHENYL
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
DU8050000
Biphenyl
92-52-4
199907
65
C12-H10
154.22
RR
Agricultural Chemical
Tumorigen
Mutagen
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* Bibenzene
* 1,1'-Biphenyl
* Biphenyl
* Carolid AL
* CP 390
* Diphenyl
* Lemonene
* MCS 1572
* Phenador-X
* Phenylbenzene
* PHPH
* Tetrosin LY
* Xenene
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 uL/24H
REACTION SEVERITY
: Severe
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0546109
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg
REACTION SEVERITY
: Mild
REFERENCE :
MONS** Monsanto Co. Toxicity Information. (Monsanto Industrial Chemicals
Co., Bancroft Bldg., Suite 204, 3411 Silverside Rd., Wilmington, DE
19810)
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 4400 ug/m3
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Gastrointestinal - nausea or vomiting
Gastrointestinal - other changes
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle
St.,
NW, Washington, DC 20016) V.11960- Volume(issue)/page/year:
26,70,1973
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2140 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
Gastrointestinal - alteration in gastric secretion
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0546109
TYPE OF TEST
: LC - Lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >200 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MONS** Monsanto Co. Toxicity Information. (Monsanto Industrial Chemicals
Co., Bancroft Bldg., Suite 204, 3411 Silverside Rd., Wilmington, DE
19810)
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 53(5),6,1988
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1900 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
SKEZAP Shokuhin Eiseigaku Zasshi. Food Hygiene Journal. (Nippon
Shokuhin
Eisei Gakkai c/o Shokuhin Eisei Senta, 2-6-1 Jingumae, Shibuya-ku, Tokyo
150, Japan) V.11960- Volume(issue)/page/year: 24,268,1983
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 56 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD
21010)
Volume(issue)/page/year: NX#00198
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: >2600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd,
eds., Nottingham, Royal Soc. of Chemistry, 1983-86
Volume(issue)/page/year:
A166,1983
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NASDA6 Nagoya Shiritsu Daigaku Igakkai Zasshi. Journal of the Nagoya
City
University Medical Association. (Nagoya-shiritsu Daigaku Igakkai, 1
Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467, Japan) V.11950Volume(issue)/page/year: 28,983,1977
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >5010 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MONS** Monsanto Co. Toxicity Information. (Monsanto Industrial Chemicals
Co., Bancroft Bldg., Suite 204, 3411 Silverside Rd., Wilmington, DE
19810)
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3300 mg/kg/15D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in bladder weight
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
57,414,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 41250 mg/kg/24W-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
Kidney, Ureter, Bladder - urine volume increased
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
3,560,1961
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 300 mg/m3/7H/94D-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Lungs, Thorax, or Respiration - emphysema
Related to Chronic Data - death
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 29,1,1947
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 150 mg/kg/3D-I
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other Enzymes
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
33,94,1975
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 5 mg/m3/7H/92D-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - emphysema
Lungs, Thorax, or Respiration - chronic pulmonary edema
Related to Chronic Data - death
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 29,1,1947
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 56 gm/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Blood - tumors
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB223-159
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 46 mg/kg
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Liver - tumors
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB223-159
** MUTATION DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
TEST SYSTEM
DOSE/DURATION
:
:
:
:
Unscheduled DNA synthesis
Oral
Rodent - rat
8400 mg/kg/4W (Continuous)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
99,37,1989
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 20 umol/L
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year:
3,193,1988
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 50 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
203,155,1988
TYPE OF TEST
: DNA damage
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 2 gm/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
395,189,1997
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 296 umol/L
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year:
3,193,1988
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 10 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
281,151,1992
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 10 mg/L
REFERENCE :
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic
Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu,
Setagaya-ku, Tokyo 158, Japan) V.11886- Volume(issue)/page/year:
(103),64,1985
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
: Sister chromatid exchange
: Rodent - hamster Fibroblast
: 100 umol/L
JNCIAM Journal of the National Cancer Institute.
V.1-60,
1940-78. For publisher information, see JJIND8.
Volume(issue)/page/year:
58,1635,1977
(Washington, DC)
*** REVIEWS ***
ACGIH TLV-TWA 1.3 mg/m3 (0.2 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
TOXICOLOGY REVIEW
AJMEAZ American Journal of Medicine.
(Technical Pub., 875 Third Ave.,
New
York, NY 10022) V.1-
1946-
Volume(issue)/page/year: 38,409,1965
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
MSHA STANDARD-air:TWA 0.2 ppm (1 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,94,1971
OSHA PEL (Gen Indu):8H TWA 0.2 ppm (1 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 0.2 ppm (1 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 0.2 ppm (1 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 0.2 ppm (1 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 0.2 ppm (1 mg/m3) JAN 1993
OEL-AUSTRIA: TWA 0.2 ppm (1.5 mg/m3), JAN1999
OEL-AUSTRALIA:TWA 0.2 ppm (1.5 mg/m3) JAN 1993
OEL-AUSTRIA:TWA 0.2 ppm (1 mg/m3) JAN 1993
OEL-DENMARK: TWA 0.2 ppm (1 mg/m3), JAN1999
OEL-BELGIUM:TWA 0.2 ppm (1.3 mg/m3) JAN 1993
OEL-FINLAND:TWA 0.2 ppm (1 mg/m3);STEL 0.6 ppm (3 mg/m3);Skin JAN 1993
OEL-GERMANY:TWA 0.2 ppm (1 mg/m3) JAN 1993
OEL-HUNGARY:TWA 1 mg/m3;STEL 2 mg/m3;Skin JAN 1993
OEL-POLAND: TWA 1 mg/m3, STEL 2 mg/m3, JAN1999
OEL-INDIA:TWA 0.2 ppm (1.5 mg/m3) JAN 1993
OEL-THE NETHERLANDS:TWA 0.2 ppm (1 mg/m3) JAN 1993
OEL-THE PHILIPPINES:TWA 0.2 ppm (1 mg/m3) JAN 1993
OEL-SWEDEN:TWA 0.2 ppm (1.3 mg/m3);STEL 0.4 ppm (2.5 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 0.2 ppm (1.3 mg/m3) JAN 1993
OEL-THAILAND:TWA 0.2 ppm (1 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 0.2 ppm (1.5 mg/m3);STEL 0.6 ppm JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO DIPHENYL-air:10H TWA 0.2 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 27590
No. of Facilities: 281 (estimated)
No. of Industries: 10
No. of Occupations: 29
No. of Employees: 10589 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 27590
No. of Facilities: 2220 (estimated)
No. of Industries: 20
No. of Occupations: 36
No. of Employees: 32003 (estimated)
No. of Female Employees: 3708 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro SCE-nonhuman
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; In
vitro
UDS in rat liver
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
47,26992,82
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Diphenyl, 2530
BIPHENYLCARBOXYLIC ACID (4-)
RTECS NUMBER
: DV1925100
CHEMICAL NAME
: 4-Biphenylcarboxylic acid
CAS REGISTRY NUMBER
: 92-92-2
BEILSTEIN REFERENCE NO. : 0973519
REFERENCE
: 4-09-00-02479 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C13-H10-O2
MOLECULAR WEIGHT
: 198.23
COMPOUND DESCRIPTOR
: Reproductive Effector
SYNONYMS/TRADE NAMES :
* (1,1'-Biphenyl)-4-carboxylic acid
* 4-Carboxybiphenyl
* 4-Diphenylcarboxylic acid
* Para phenyl benzoic acid
* p-Phenylbenzoic acid
* 4-Phenylbenzoic acid
*** HEALTH HAZARD DATA ***
** REPRODUCTIVE DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: TDLo - Lowest published toxic dose
: Oral
: Rodent - rat
DOSE
: 1 gm/kg
SEX/DURATION
: female 7-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - fetal death
Reproductive - Specific Developmental Abnormalities - body wall
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 39,537,1989
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BIS OXOOXAZOLIDINYL PHOSPHINIC CHLORIDE (2:3-)
RTECS NUMBER
: SZ5871000
CHEMICAL NAME
: Phosphinic chloride, bis(2-oxo-3-oxazolidinyl)CAS REGISTRY NUMBER
: 68641-49-6
LAST UPDATED
: 199410
DATA ITEMS CITED
: 1
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Bis(2-oxo-3-oxazolidinyl)phosphinic chloride
*** HEALTH HAZARD DATA ***
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 100 ug/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
170,23,1986
BIS TRIMETHYLSILYL ACETAMIDE (N,O-)
RTECS NUMBER
: AK3000000
CHEMICAL NAME
: Acetimidic acid, N-(trimethylsilyl)-,
trimethylsilyl
ester
CAS REGISTRY NUMBER
: 10416-59-8
BEILSTEIN REFERENCE NO. : 1306669
LAST UPDATED
: 199707
DATA ITEMS CITED
: 4
MOLECULAR FORMULA
: C8-H21-N-O-Si2
MOLECULAR WEIGHT
: 203.48
WISWESSER LINE NOTATION : 1-SI-1&1&OY1&UN-SI-1&1&1
COMPOUND DESCRIPTOR
: Tumorigen
SYNONYMS/TRADE NAMES :
* Ethanimidic acid, N-(trimethylsilyl)-, trimethylsilyl ester
* N-(Trimethylsilyl)acetimidic acid, trimethylsilyl ester
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 750 mg/kg
TOXIC EFFECTS :
Immunological Including Allergic - decreased immune response
REFERENCE :
StoGD# Personal Communication from G.D. Stoner, Dept. of Community
Medicine,
School of Medicine, Univ. of California, La Jolla, CA 92037, May 25, 1975
Volume(issue)/page/year: 27MAY1975
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 500 mg/kg/I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC)
V.1-60,
1940-78. For publisher information, see JJIND8.
Volume(issue)/page/year:
54,495,1975
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X7061
No. of Facilities: 10 (estimated)
No. of Industries: 2
No. of Occupations: 2
No. of Employees: 226 (estimated)
No. of Female Employees: 151 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BIS TRIPHENYLPHOSPHINE NICKEL(II) CHLORIDE
RTECS NUMBER
: QR6170000
CHEMICAL NAME
: Nickel, bis(triphenylphosphine)dichloroCAS REGISTRY NUMBER
: 14264-16-5
LAST UPDATED
: 199701
DATA ITEMS CITED
: 8
MOLECULAR FORMULA
: C36-H30-Cl2-Ni-P2
MOLECULAR WEIGHT
: 654.21
WISWESSER LINE NOTATION : 4P4&4 2 &G-NI-G
SYNONYMS/TRADE NAMES :
* Bis(tri-N-butylphosphine)dichloronickel
* Nickel, dichlorobis(triphenylphosphine)* Phosphine, tributyl-, compd. with nickelchloride (2:1)
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 56 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD
21010)
Volume(issue)/page/year: NX#03119
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 1 mg(Ni)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,178,1971
OSHA PEL (Gen Indu):8H TWA 1 mg(Ni)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 1 mg(Ni)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 1 mg(Ni)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 1 mg(Ni)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO NICKEL, INORGANIC-air:10H CA TWA 0.015 mg(Ni)/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BISBENZIMIDE
RTECS NUMBER
CHEMICAL NAME
: SM1140500
: Phenol,
p-(5-(5-(4-methyl-1-piperazinyl)-2-benzimidazolyl)-2benzimidazolyl)-, trihydrochloride
CAS REGISTRY NUMBER
: 23491-45-4
LAST UPDATED
: 199709
DATA ITEMS CITED
: 14
MOLECULAR FORMULA
: C25-H24-N6-O.3Cl-H
MOLECULAR WEIGHT
: 533.93
WISWESSER LINE NOTATION : T56 BM DNJ CR DQ& G- CT56 BM DNJ G- AT6N DNTJ D1
&GH
3
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Bisbenzimidazole trihydrochloride
* Bisbenzimide
* H 33258
* HOE 33058
* HOE 33258
* 33258 Hoechst
* Hoechst 33258
* Hoechst Dye 33258
* NSC-322921
* Phenol, 4-(5-(4-methyl-1-piperazinyl)(2,5'-bi-1H-benzimidazol)-2'-yl)-,
trihydrochloride
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 32200 ug/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
Skin and Appendages - hair
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB84-171206
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 36900 ug/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
Skin and Appendages - hair
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB84-171206
** MUTATION DATA **
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 10 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
89,95,1981
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 2 umol/L
REFERENCE :
CHROAU Chromosoma. (Springer-Verlag New York, Inc., Service Center, 44
Hartz Way, Secaucus, NJ 07094) V.11939- Volume(issue)/page/year:
52,297,1975
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 2 umol/L
REFERENCE :
CHROAU Chromosoma. (Springer-Verlag New York, Inc., Service Center, 44
Hartz Way, Secaucus, NJ 07094) V.11939- Volume(issue)/page/year:
52,297,1975
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - rat Fibroblast
DOSE/DURATION
: 1 mg/L
REFERENCE :
ZZACAG Zeitschrift fuer Zellforschung und Mikroskopische Anatomie.
(Berlin,
Fed. Rep. Ger.) V.1-147, 1924-73. For publisher information, see CTSRCS.
Volume(issue)/page/year: 104,127,1970
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - mouse Fibroblast
DOSE/DURATION
: 1 mg/L
REFERENCE :
ZZACAG Zeitschrift fuer Zellforschung und Mikroskopische Anatomie.
(Berlin,
Fed. Rep. Ger.) V.1-147, 1924-73. For publisher information, see CTSRCS.
Volume(issue)/page/year: 104,127,1970
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Cells - not otherwise specified
DOSE/DURATION
: 80 mg/L
REFERENCE :
CHROAU Chromosoma. (Springer-Verlag New York, Inc., Service Center, 44
Hartz Way, Secaucus, NJ 07094) V.11939- Volume(issue)/page/year:
56,41,1976
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 10 umol/L
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ
08736)
V.11869- Volume(issue)/page/year: 258,121,1975
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 15 umol/L
REFERENCE :
HEREAY Hereditas (Lund, Sweden). (Gjoerloffsgatan 121, S-261 34
Landskrona,
Sweden) V.11947- Volume(issue)/page/year: 96,295,1982
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Mammal - species unspecified Lymphocyte
DOSE/DURATION
: 1600 nmol/L
REFERENCE :
CHROAU Chromosoma. (Springer-Verlag New York, Inc., Service Center, 44
Hartz Way, Secaucus, NJ 07094) V.11939- Volume(issue)/page/year:
52,297,1975
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro SCE-nonhuman
EPA GENETOX PROGRAM 1988, Negative: In vivo SCE-nonhuman
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BISBENZIMIDE TRIHYDROCHLORIDE
RTECS NUMBER
: DT4200000
CHEMICAL NAME
: 2,5'-Bibenzimidazole,
2'-(p-ethoxyphenyl)-5-(4-methyl-1-piperazinyl)CAS REGISTRY NUMBER
: 23491-52-3
LAST UPDATED
: 199812
DATA ITEMS CITED
: 4
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* 2,5'-Bi-1H-benzimidazole,
2'-(4-ethoxyphenyl)-5-(4-methyl-1-piperazinyl)* Bisbenzimide
* Ho 342
* HOE 33342
* Hoechst 33342
*** HEALTH HAZARD DATA ***
** MUTATION DATA **
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human HeLa cell
DOSE/DURATION
: 300 nmol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 13,2389,1992
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - mouse Fibroblast
DOSE/DURATION
: 5 umol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 9,485,1988
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 1 umol/L
REFERENCE :
JHCYAS Journal of Histochemistry and Cytochemistry. (Elsevier Science
Pub.
Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.11953Volume(issue)/page/year: 30,111,1982
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 1 umol/L
REFERENCE :
JHCYAS Journal of Histochemistry and Cytochemistry. (Elsevier Science
Pub.
Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.11953Volume(issue)/page/year: 30,111,1982
BISCHLOROETHOXYETHANE (1,2-)
RTECS NUMBER
: KH4900000
CHEMICAL NAME
: Ethane, 1,2-bis(2-chloroethoxy)CAS REGISTRY NUMBER
: 112-26-5
BEILSTEIN REFERENCE NO. : 0506177
REFERENCE
: 4-01-00-02379 (Beilstein Handbook Reference)
LAST UPDATED
: 199710
DATA ITEMS CITED
: 7
MOLECULAR FORMULA
: C6-H12-Cl2-O2
MOLECULAR WEIGHT
: 187.08
WISWESSER LINE NOTATION : G2O2O2G
COMPOUND DESCRIPTOR
: Primary Irritant
SYNONYMS/TRADE NAMES :
* 1,2-Bis(2-chloroethoxy)ethane
* 2-(2-Chlorethoxy)ethyl 2'-chlorethyl ether
* 2-(2-Chloroethoxy)ethyl 2'-chloroethyl ether
* Triethylene glycol dichloride
* Triglycol dichloride
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Open irritation test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg
REACTION SEVERITY
: Mild
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 8/28/1957
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg
REACTION SEVERITY
: Severe
REFERENCE :
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N.
Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.11918Volume(issue)/page/year: 29,1363,1946
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 8/28/1957
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1410 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 8/28/1957
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 120 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
Gastrointestinal - other changes
Kidney, Ureter, Bladder - other changes
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 23,259,1941
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
BISCHLOROETHYLAMINE HYDROCHLORIDE
RTECS NUMBER
: IA1225000
CHEMICAL NAME
: Diethylamine, 2,2'-dichloro-, hydrochloride
CAS REGISTRY NUMBER
: 821-48-7
LAST UPDATED
: 199701
DATA ITEMS CITED
: 17
MOLECULAR FORMULA
: C4-H9-Cl2-N.Cl-H
MOLECULAR WEIGHT
: 178.50
WISWESSER LINE NOTATION : G2M2G &GH
COMPOUND DESCRIPTOR
: Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Bis(beta-chloroethyl)-amine hydrochloride
* Bis(2-chloroethyl)amine hydrochloride
* N,N-Bis(2-chloroethyl)amine hydrochloride
* Bis(2-chloroethyl)ammonium chloride
* 2-Chloro-N-(2-chloroethyl)ethanamine hydrochloride
* Di-2-chloroethylamine hydrochloride
* beta,beta'-Dichlorodiethylamine hydrochloride
* 2,2'-Dichlorodiethylamine hydrochloride
* Ethanamine, 2-chloro-N-(2-chloroethyl)-, hydrochloride
* LEO 72a
* NC 26
* Nor-HN2
* Nor-HN2 hydrochloride
* Nor-lost hydrochlorid
* Nornitrogen mustard hydrochloride
* NSC 10873
* SK 555
* TL 161
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 11,143,1961
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 160 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie. (Berlin,
Fed. Rep. Ger.) V.76-92, 1971-78. For publisher information, see
JCROD7.
Volume(issue)/page/year: 84,227,1975
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1000 mg/m3/10M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NDRC** National Defense Research Committee, Office of Scientific Research
and Development, Progress Report. Volume(issue)/page/year:
NDCrc-132,JUL1942
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 20 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 91,224,1947
V.1-
1909/10-
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 280 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARPMAS Archiv der Pharmazie (Weinheim, Germany) (VCH Pub., Inc., 303 NW
12th Ave., Deerfield Beach, FL 33441) V.51-261, 1835-1923; V.3051972Volume(issue)/page/year: 306,64,1973
** REPRODUCTIVE DATA **
TYPE OF TEST
:
ROUTE OF EXPOSURE
:
SPECIES OBSERVED
:
DOSE
:
SEX/DURATION
:
TOXIC EFFECTS :
Reproductive - Effects
e.g., stunted fetus)
REFERENCE :
TJADAB Teratology, The
TDLo - Lowest published toxic dose
Intraperitoneal
Rodent - mouse
2500 ug/kg
female 11 day(s) after conception
on Embryo or Fetus - fetotoxicity (except death,
International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003)
Volume(issue)/page/year: 4,141,1971
V.1-
1968-
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 40 mg/kg
SEX/DURATION
: female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 4,141,1971
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 50 ug/plate
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United
States
of America. (National Academy of Sciences, Printing & Pub. Office, 2101
Constitution Ave., Washington, DC 20418) V.11915Volume(issue)/page/year: 72,979,1975
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 100 ug/plate
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 5,1637,1984
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 500 umol/L
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 3,637,1977
TYPE OF TEST
: Phage inhibition capacity
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 200 mg/L
REFERENCE :
ARMKA7 Archiv fuer Mikrobiologie. (Berlin, Fed. Rep. Ger.)
1930-73. For publisher information, see AMICCW.
Volume(issue)/page/year:
51,9,1965
TYPE OF TEST
TEST SYSTEM
V.1-94,
: DNA repair
: Microorganism - not otherwise specified
DOSE/DURATION
: 20 gm/L
REFERENCE :
STBIBN Studia Biophysica. (Akademie-Verlag GmbH, Postfach 1233, Berlin
DDR-1086, Ger. Dem. Rep.) V.11966- Volume(issue)/page/year:
117,99,1987
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 1 mg/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 5,1637,1984
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 250 ug/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 5,1637,1984
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Rodent - mouse Ascites tumor
DOSE/DURATION
: 170 umol/kg
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
33,1048,1973
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BISCYCLOPENTADIENYL COBALT
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
WISWESSER LINE NOTATION :
COMPOUND DESCRIPTOR
:
GG0350000
Cobalt, di-pi-cyclopentadienyl1277-43-6
199701
5
C10-H10-Co
189.13
L50J 0-CO-- 0L50J
Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* Bis(cyclopentadienyl)cobalt
* Cobaltocene
* Dicyclopentadienylcobalt
* Kobaltocen
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 55 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCIUS* Progress Report for Contract No. PH-43-64-886, Submitted to the
National Cancer Institute by The Institute of Chemical Biology,
University
of San Francisco. (San Francisco, CA 94117) Volume(issue)/page/year:
PH43-64-886
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 80 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCIUS* Progress Report for Contract No. PH-43-64-886, Submitted to the
National Cancer Institute by The Institute of Chemical Biology,
University
of San Francisco. (San Francisco, CA 94117) Volume(issue)/page/year:
PH43-64-886
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 200 mg/kg/60W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
NCIUS* Progress Report for Contract No. PH-43-64-886, Submitted to the
National Cancer Institute by The Institute of Chemical Biology,
University
of San Francisco. (San Francisco, CA 94117) Volume(issue)/page/year:
PH43-64-886
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 3333 ug/plate
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
19(Suppl 21),2,1992
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BISDIMETHYL AMINOBENZHYDROL
RTECS NUMBER
: DC7525000
CHEMICAL NAME
: Benzhydrol, 4,4'-bis-(dimethylamino)CAS REGISTRY NUMBER
: 119-58-4
BEILSTEIN REFERENCE NO. : 2131843
REFERENCE
: 4-13-00-02148 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C17-H22-N2-O
MOLECULAR WEIGHT
: 270.41
WISWESSER LINE NOTATION : 1N1&R DYQR DN1&1
SYNONYMS/TRADE NAMES :
* 4,4'-Bis(dimethylamino)benzohydrol
* alpha,alpha-Bis(p-dimethylaminophenyl)methanol
* Michler's hydrol
* p,p'-Michler's hydrol
* Tetramethyldiaminobenzhydrol
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 90,260,1947
V.1-
1909/10-
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CBCCT* "Summary Tables of Biological Tests," National Research Council
Chemical-Biological Coordination Center. (National Academy of Science
Library, 2101 Constitution Ave., NW, Washington, DC 20418)
Volume(issue)/page/year: 4,227,1952
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BISETHYLHEXYL SULFOSUCCINATE SODIUM (2-)
RTECS NUMBER
: WN0525000
CHEMICAL NAME
: Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl)
ester,
sodium salt
CAS REGISTRY NUMBER
: 577-11-7
OTHER CAS REGISTRY NOS. : 53023-94-2
LAST UPDATED
: 199710
DATA ITEMS CITED
: 17
MOLECULAR FORMULA
: C20-H38-O7-S.Na
MOLECULAR WEIGHT
: 445.63
WISWESSER LINE NOTATION : 2Y2&3OVYSWQ1VO3Y2&2 &-NACOMPOUND DESCRIPTOR
: Reproductive Effector
Primary Irritant
SYNONYMS/TRADE NAMES :
* Aerosol GPG
* Aerosol OT
* Aerosol OT 75
* Aerosol OT-B
* Alcopol O
* Alphasol OT
* Berol 478
* Bis(ethylhexyl) ester of sodium sulfosuccinic acid
* Bis-2-ethylhexylester sulfojantaranu sodneho
* Bis(2-ethylhexyl)sodium sulfosuccinate
* Bis(2-ethylhexyl) S-sodium sulfosuccinate
* 1,4-Bis(2-ethylhexyl) sodium sulfosuccinate
* Butanedioic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt
* Celanol DOS 75
* Clestol
* Colace
* Complemix
* Constonate
* Coprol
* Defilin
* Di-(2-ethylhexyl) sodium sulfosuccinate
* Dioctlyn
* Dioctylal
* Dioctyl ester of sodium sulfosuccinate
* Dioctyl ester of sodium sulfosuccinic acid
* Dioctyl-medo forte
* Dioctyl sodium sulfosuccinate
* Dioctyl sulfosuccinate sodium
* Dioctyl sulfosuccinate sodium salt
* Diomedicone
* Diosuccin
* Diotilan
* Diovac
* Docusate sodium
* Doxinate
* Doxol
* D-S-S
* Dulsivac
* Duosol
* 2-Ethylhexyl sulfosuccinate sodium
* Humifen WT 27G
* Konlax
* Kosate
* Laxinate
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
Laxinate 100
Manoxal OT
Manoxol OT
Mervamine
Modane soft
Molatoc
Molcer
Molofac
Monawet MD 70E
Monawet MO-70
Monawet MO-70 RP
Monawet MO-84 R2W
Monoxol OT
Nekal WT-27
Nevax
Nikkol OTP 70
Norval
Obston
Rapisol
Regutol
Requtol
Revac
Sanmorin OT 70
SBO
Sobital
Sodium bis(2-ethylhexyl) sulfosuccinate
Sodium di-(2-ethylhexyl) sulfosuccinate
Sodium dioctyl sulfosuccinate
Sodium dioctyl sulphosuccinate
Sodium 2-ethylhexylsulfosuccinate
Sodium sulfodi-(2-ethylhexyl)-sulfosuccinate
Softil
Sol sodowej sulfobursztynianu dwu-2-etyloheksylowego
Soliwax
Solusol-75%
Solusol-100%
Sulfimel DOS
Sulfosuccinic acid, bis(2-ethylhexyl)ester sodium salt
SV 102
Tex-Wet 1001
Triton GR-5
Triton GR 7
Vatsol OT
Velmol
Waxsol
Wetaid SR
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 10 mg/24H
REACTION SEVERITY
: Moderate
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
&
(Williams
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 82,377,1944
V.1-
1909/10-
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 250 ug
REACTION SEVERITY
: Mild
REFERENCE :
AROPAW Archives of Ophthalmology (Chicago). (AMA, 535 N. Dearborn St.,
Chicago, IL 60610) New series: V.1-44(3), 1929-50; V.641960Volume(issue)/page/year: 34,99,1945
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1%
REACTION SEVERITY
: Severe
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific
Edition. (Washington, DC) V.29-49, 1940-60. For publisher information,
see
JPMSAE. Volume(issue)/page/year: 38,428,1949
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JSCCA5 Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic
Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.11947Volume(issue)/page/year: 13,469,1962
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 590 mg/kg
TOXIC EFFECTS :
Vascular - structural changes in vessels
REFERENCE :
BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001,
00-068
Warsaw 1, Poland) V.41971- Volume(issue)/page/year: 7,161,1974
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2643 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave.,
New
York, NY 10016) V.11977/78- Volume(issue)/page/year: 1,89,1977/1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 60 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific
Edition. (Washington, DC) V.29-49, 1940-60. For publisher information,
see
JPMSAE. Volume(issue)/page/year: 38,428,1949
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 42 gm/kg/12W-C
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Metabolism (Intermediary) - lipids including transport
REFERENCE :
BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001,
00-068
Warsaw 1, Poland) V.41971- Volume(issue)/page/year: 9,159,1976
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 12 gm/kg/30D-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific
Edition. (Washington, DC) V.29-49, 1940-60. For publisher information,
see
JPMSAE. Volume(issue)/page/year: 38,428,1949
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 84 mg/kg/24W-I
TOXIC EFFECTS :
Behavioral - food intake (animal)
Gastrointestinal - hypermotility, diarrhea
Related to Chronic Data - death
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 25,175,1943
** REPRODUCTIVE DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
TOXIC EFFECTS :
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
8820 mg/kg
multigeneration
Reproductive - Effects on Newborn - other postnatal measures or effects
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 15,53,1990
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83280
No. of Facilities: 3817 (estimated)
No. of Industries: 53
No. of Occupations: 74
No. of Employees: 45527 (estimated)
NOES - National Occupational
NOES Hazard Code - 83280
No. of Facilities: 11668
No. of Industries: 95
No. of Occupations: 100
No. of Employees: 180694
No. of Female Employees:
Exposure Survey (1983)
(estimated)
(estimated)
49329 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
BISMUTH
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
* Bismuth-209
:
:
:
:
:
:
:
:
EB2600000
Bismuth
7440-69-9
199712
11
Bi
208.98
Human
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 221 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena,
J.M.,
Springfield, IL, C.C. Thomas, 1970 Volume(issue)/page/year: 2,73,1970
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 30(6),16,1986
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 30(6),16,1986
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 535 mg/kg
TOXIC EFFECTS :
Behavioral - food intake (animal)
Behavioral - coma
Kidney, Ureter, Bladder - urine volume decreased
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 28,121,1926
V.1-
1909/10-
*** REVIEWS ***
TOXICOLOGY REVIEW
ADSYAF Archives of Dermatology and Syphilology. (Chicago, IL)
1920-50. For publisher information, see ARDEAC.
Volume(issue)/page/year:
26,797,1932
V.1-62,
TOXICOLOGY REVIEW
PTPAD4 Pharmacology and Therapeutics, Part A: Chemotherapy, Toxicology
and
Metabolic Inhibitors. (Oxford, UK) V.1-2, 1976-78. For publisher
information, see PHTHDT. Volume(issue)/page/year: 1,153,1976
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 0.5 mg/m3 JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 12783
No. of Facilities: 365 (estimated)
No. of Industries: 11
No. of Occupations: 35
No. of Employees: 20336 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 12783
No. of Facilities: 451 (estimated)
No. of Industries: 14
No. of Occupations: 34
No. of Employees: 14666 (estimated)
No. of Female Employees: 4387 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
BISMUTH OXYNITRATE CRYSTALLINE
RTECS NUMBER
: EB2977000
CHEMICAL NAME
: Bismuth hydroxide nitrate oxide
CAS REGISTRY NUMBER
: 1304-85-4
OTHER CAS REGISTRY NOS. : 54392-33-5
LAST UPDATED
: 199701
DATA ITEMS CITED
: 4
MOLECULAR FORMULA
: Bi5-H9-N4-O22
MOLECULAR WEIGHT
: 1462.03
COMPOUND DESCRIPTOR
: Drug
Human
SYNONYMS/TRADE NAMES :
* Basic bismuth nitrate
* Bismuth magistery
* Bismuth subnitrate
* Bismuth subnitricum
* Bismuth White
* Bismuthyl nitrate
* Blanc de fard
* C.I. 77169
* C.I. Pigment White 17
* Cosmetic White
* Flake White
*
*
*
*
*
*
Magistery of bismuth
Novismuth
Paint White
Snowcal 5SW
Spanish White
Vicalin
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - infant
DOSE/DURATION
: 259 mg/kg
TOXIC EFFECTS :
Blood - methemoglobinemia-carboxyhemoglobin
REFERENCE :
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N.
Dearborn St., Chicago, IL 60610) V.11883- Volume(issue)/page/year:
133,1280,1947
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - infant
DOSE/DURATION
: 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
Academic Press, Inc., 1969 Volume(issue)/page/year: -,134,1969
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X3849
No. of Facilities: 142 (estimated)
No. of Industries: 2
No. of Occupations: 5
No. of Employees: 10190 (estimated)
No. of Female Employees: 9898 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BISMUTH SUBNITRATE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
:
:
:
:
:
:
:
EB2984400
Bismuth nitrate
10361-44-1
199701
7
N3-O9.Bi
395.01
WISWESSER LINE NOTATION : .BI..N-O3*3
COMPOUND DESCRIPTOR
: Reproductive Effector
SYNONYMS/TRADE NAMES :
* Nitric acid, bismuth(3+) salt
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353
Vineuil,
France) V.11943- Volume(issue)/page/year: 34,173,1976
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 21 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353
Vineuil,
France) V.11943- Volume(issue)/page/year: 34,173,1976
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intratesticular
SPECIES OBSERVED
: Rodent - rat
DOSE
: 31601 ug/kg
SEX/DURATION
: male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book
Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.11960Volume(issue)/page/year: 7,21,1964
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 31601 ug/kg
SEX/DURATION
: male 30 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book
Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.11960Volume(issue)/page/year: 7,21,1964
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 81728
No. of Facilities: 78 (estimated)
No. of Industries: 3
No. of Occupations: 4
No. of Employees: 430 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 81728
No. of Facilities: 156 (estimated)
No. of Industries: 4
No. of Occupations: 6
No. of Employees: 921 (estimated)
No. of Female Employees: 89 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BISMUTH TRINITRATE PENTAHYDRATE
RTECS NUMBER
: EB2984430
CHEMICAL NAME
: Bismuth nitrate, hydrate (1:5)
CAS REGISTRY NUMBER
: 10035-06-0
LAST UPDATED
: 199606
DATA ITEMS CITED
: 4
MOLECULAR FORMULA
: Bi-N3-O9.5H2-O
MOLECULAR WEIGHT
: 485.11
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
* Bismuth nitrate pentahydrate
* Bismuth trinitrate pentahydrate
* Nitric acid, bismuth(3+) salt, pentahydrate
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4042 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 30(6),16,1986
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3710 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 30(6),16,1986
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 71 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270
Madison Ave., New York, NY 10016) V.191982Volume(issue)/page/year:
20,159,1983
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2 mg/m3/17W-I
TOXIC EFFECTS :
Cardiac - EKG changes not diagnostic of specified effects
Endocrine - hypoglycemia
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 30(6),16,1986
BISMUTH(III) CHLORIDE
RTECS NUMBER
: EB2690000
CHEMICAL NAME
: Bismuth chloride
CAS REGISTRY NUMBER
: 7787-60-2
LAST UPDATED
: 199701
DATA ITEMS CITED
: 5
MOLECULAR FORMULA
: Bi-Cl3
MOLECULAR WEIGHT
: 315.33
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Bismuthine, trichloro* Bismuth trichloride
* Trichlorobismuth
* Trichlorobismuthine
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3334 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 30(6),16,1986
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 30(6),16,1986
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 12785
No. of Facilities: 99 (estimated)
No. of Industries: 4
No. of Occupations: 3
No. of Employees: 15745 (estimated)
No. of Female Employees: 4477 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BISPHENOL A
RTECS NUMBER
: SL6300000
CHEMICAL NAME
: Phenol, 4,4'-isopropylidenediCAS REGISTRY NUMBER
: 80-05-7
BEILSTEIN REFERENCE NO. : 1107700
REFERENCE
: 4-06-00-06717 (Beilstein Handbook Reference)
LAST UPDATED
: 199904
DATA ITEMS CITED
: 51
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
C15-H16-O2
228.31
QR DX1&1&R DQ
Tumorigen
Mutagen
Reproductive Effector
Primary Irritant
SYNONYMS/TRADE NAMES :
* Bisferol A
* 2,2-Bis-4'-hydroxyfenylpropan
* Bis(4-hydroxyphenyl) dimethylmethane
* Bis(4-hydroxyphenyl)propane
* 2,2-Bis(p-hydroxyphenyl)propane
* 2,2-Bis(4-hydroxyphenyl)propane
* Bisphenol
* Bisphenol A
* 4,4'-Bisphenol A
* DIAN
* p,p'-Dihydroxydiphenyldimethylmethane
* 4,4'-Dihydroxydiphenyldimethylmethane
* p,p'-Dihydroxydiphenylpropane
* 2,2-(4,4'-Dihydroxydiphenyl)propane
* 4,4'-Dihydroxydiphenylpropane
* 4,4'-Dihydroxydiphenyl-2,2-propane
* 4,4'-Dihydroxy-2,2-diphenylpropane
* Dimethylmethylene-p,p'-diphenol
* beta-Di-p-hydroxyphenylpropane
* 2,2-Di(4-hydroxyphenyl)propane
* Dimethyl bis(p-hydroxyphenyl)methane
* Diphenylolpropane
* 2,2-Di(4-phenylol)propane
* p,p'-Isopropylidenebisphenol
* 4,4'-Isopropylidenebisphenol
* p,p'-Isopropylidenediphenol
* NCI-C50635
* Phenol, 4,4'-dimethylmethylenedi* Propane, 2,2-bis(p-hydroxyphenyl)* Ucar bisphenol A
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Open irritation test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 250 mg
REACTION SEVERITY
: Mild
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury
Rd., Danbury, CT 06817) Volume(issue)/page/year: 7/14/1965
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986
-,238,1986
Volume(issue)/page/year:
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 250 ug/24H
REACTION SEVERITY
: Severe
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year:
-,238,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
28,301,1967
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2400 mg/kg
TOXIC EFFECTS :
Autonomic Nervous System - other (direct) parasympathomimetic
Behavioral - convulsions or effect on seizure threshold
Behavioral - ataxia
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 33(7),25,1968
TYPE OF TEST
: LC - Lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >1700 mg/m3/2H
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.
Toxicology of New Industrial Chemical Substances. For English
translation,
see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.11961Volume(issue)/page/year: 2,50,1961
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Intraperitoneal
Rodent - mouse
150 mg/kg
(V/O
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD691-490
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2500 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Liver - fatty liver degeneration
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.
Toxicology of New Industrial Chemical Substances. For English
translation,
see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.11961Volume(issue)/page/year: 2,50,1961
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2230 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
28,301,1967
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 3 mL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 4,119,1951
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 4 gm/kg
TOXIC EFFECTS :
Autonomic Nervous System - other (direct) parasympathomimetic
Behavioral - convulsions or effect on seizure threshold
Behavioral - ataxia
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 33(7),25,1968
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LD50 - Lethal dose, 50 percent kill
: Oral
: Mammal - species unspecified
(V/O
DOSE/DURATION
: 6500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
Academic Press, Inc., 1969 Volume(issue)/page/year: -,135,1969
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 12 mg/kg/12D-I
TOXIC EFFECTS :
Liver - fatty liver degeneration
Related to Chronic Data - death
REFERENCE :
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.
Toxicology of New Industrial Chemical Substances. For English
translation,
see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.11961Volume(issue)/page/year: 2,50,1961
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 42 gm/kg/8W-C
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 9,9,1959
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5460 mg/kg/13W-C
TOXIC EFFECTS :
Gastrointestinal - other changes
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-215,1982
(Research
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 31500 mg/kg/9W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - urine volume increased
Liver - other changes
Blood - other hemolysis with or without anemia
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 33(7),25,1968
(V/O
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 455 mg/kg/26W-I
TOXIC EFFECTS :
Behavioral - alteration of classical conditioning
Liver - liver function tests impaired
Blood - other changes
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 33(7),25,1968
(V/O
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 150 mg/m3/6H/13W-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.11981- Volume(issue)/page/year: 8,248,1988
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 47 mg/m3/2H/19W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - urine volume decreased
Endocrine - changes in spleen weight
REFERENCE :
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.
Toxicology of New Industrial Chemical Substances. For English
translation,
see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.11961Volume(issue)/page/year: 4,43,1962
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 273 gm/kg/13W-C
TOXIC EFFECTS :
Liver - other changes
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-215,1982
(Research
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 200 mg/m3/2H/41D-I
TOXIC EFFECTS :
Liver - fatty liver degeneration
Kidney, Ureter, Bladder - other changes
Related to Chronic Data - death
REFERENCE :
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.
Toxicology of New Industrial Chemical Substances. For English
translation,
see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.11961Volume(issue)/page/year: 2,50,1961
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 31500 mg/kg/9W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition
Blood - changes in erythrocyte (RBC) count
Biochemical - Metabolism (Intermediary) - lipids including transport
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 33(7),25,1968
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 4550 mg/kg/26W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Endocrine - other changes
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 33(7),25,1968
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 10 gm/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB85-205110
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 15 gm/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB85-205110
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1275 mg/kg
SEX/DURATION
: female 1-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
SWEHDO Scandinavian Journal of Work, Environment and Health.
(Haartmaninkatu
1, SF-00290 Helsinki, 29, Finland) V.11975Volume(issue)/page/year:
7(Suppl 4),66,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1275 mg/kg
SEX/DURATION
: female 1-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
APTOD9 Abstracts of Papers, Society of Toxicology. Annual Meetings.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
Volume(issue)/page/year: 19,A23,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1875 mg/kg
SEX/DURATION
: female 1-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter;
measured
before birth)
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora
lutea)
REFERENCE :
APTOD9 Abstracts of Papers, Society of Toxicology. Annual Meetings.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
Volume(issue)/page/year: 19,A23,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1275 mg/kg
SEX/DURATION
: female 1-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter;
measured
before birth)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
REFERENCE :
SWEHDO Scandinavian Journal of Work, Environment and Health.
(Haartmaninkatu
1, SF-00290 Helsinki, 29, Finland) V.11975Volume(issue)/page/year:
7(Suppl 4),66,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1875 mg/kg
SEX/DURATION
: female 1-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Specific Developmental Abnormalities - gastrointestinal
system
REFERENCE :
SWEHDO Scandinavian Journal of Work, Environment and Health.
(Haartmaninkatu
1, SF-00290 Helsinki, 29, Finland) V.11975Volume(issue)/page/year:
7(Suppl 4),66,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 12500 mg/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB85-205102
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 7500 mg/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora
lutea)
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB85-205102
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: TDLo - Lowest published toxic dose
: Oral
: Rodent - mouse
DOSE
: 12500 mg/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB85-205102
** MUTATION DATA **
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 200 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
368,59,1996
TYPE OF TEST
: DNA adduct
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 200 mg/kg
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
26,60,1995
TYPE OF TEST
: DNA adduct
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 800 mg/kg/4D (Continuous)
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
26,60,1995
TYPE OF TEST
: Micronucleus test
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 200 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
390,21,1997
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 400 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
400,169,1998
TYPE OF TEST
TEST SYSTEM
DOSE/DURATION
REFERENCE :
: Cytogenetic analysis
: Rodent - hamster Ovary
: 400 umol/L
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
400,169,1998
*** REVIEWS ***
TOXICOLOGY REVIEW
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 13,747,1989
*** U.S. STANDARDS AND REGULATIONS ***
OSHA PEL (Shipyard):CL 0.5 ppm (2.8 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 5 mg/m3 JAN 1993
OEL-THAILAND:TWA 0.5 ppm (2.8 mg/m3) JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 12845
No. of Facilities: 5427 (estimated)
No. of Industries: 82
No. of Occupations: 74
No. of Employees: 71597 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - T0995
No. of Facilities: 6 (estimated)
No. of Industries: 2
No. of Occupations: 2
No. of Employees: 2180 (estimated)
No. of Female Employees: 49 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 12845
No. of Facilities: 5987 (estimated)
No. of Industries: 70
No. of Occupations: 78
No. of Employees: 92138 (estimated)
No. of Female Employees: 15144 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NTP Carcinogenesis Bioassay (feed);inadequate studies:mouse,rat
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-215,1982
BORANE-DIMETHYLAMINE COMPLEX
RTECS NUMBER
: IP9450000
CHEMICAL NAME
: Dimethylamine, compd. with borane (1:1)
CAS REGISTRY NUMBER
: 74-94-2
LAST UPDATED
: 199806
DATA ITEMS CITED
: 15
MOLECULAR FORMULA
: C2-H10-B-N
MOLECULAR WEIGHT
: 58.94
WISWESSER LINE NOTATION : 1M1 &BHHH
COMPOUND DESCRIPTOR
: Drug
Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* Borane, compd. with dimethylamine (1:1)
* Boron, (N-methylmethanamine)trihydro-, (T-4)* Dimethylamine borane
* Methanamine, N-methyl-, compd. with borane (1:1)
* N-Methylmethanamine compd. with borane (1:1)
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 50 mg
REACTION SEVERITY
: Mild
REFERENCE :
JOCMA7 Journal of Occupational Medicine. (Chicago, IL) V.1-9,
1957-67.
For publisher information, see:JJOMDZ Volume(issue)/page/year: 1,46,1959
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 10 mg
REFERENCE :
JOCMA7 Journal of Occupational Medicine. (Chicago, IL) V.1-9,
1957-67.
For publisher information, see:JJOMDZ Volume(issue)/page/year: 1,46,1959
** ACUTE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Oral
Rodent - rat
59 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHQA5 American Industrial Hygiene Association Quarterly. (Baltimore,
MD)
V.7-18, 1946-57. For publisher information, see AIHAAP.
Volume(issue)/page/year: 16,280,1955
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 39 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
14KTAK "Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed.,
New
York, John Wiley & Sons, Inc., 1964 Volume(issue)/page/year: -,693,1964
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0535833
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical
Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.501961Volume(issue)/page/year: 69,1025,1980
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 56 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD
21010)
Volume(issue)/page/year: NX#05150
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Administration onto the skin
Rodent - rabbit
210 mg/kg
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0535833
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 35100 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
14KTAK "Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed.,
New
York, John Wiley & Sons, Inc., 1964 Volume(issue)/page/year: -,693,1964
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0535833
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 55900 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
14KTAK "Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed.,
New
York, John Wiley & Sons, Inc., 1964 Volume(issue)/page/year: -,693,1964
** MUTATION DATA **
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - mouse Ascites tumor
DOSE/DURATION
: 100 umol/L
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical
Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.501961Volume(issue)/page/year: 74,755,1985
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Rodent - mouse Ascites tumor
DOSE/DURATION
: 100 umol/L
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical
Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.501961Volume(issue)/page/year: 74,755,1985
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
BORANE-PYRIDINE COMPLEX
RTECS NUMBER
: US3675000
CHEMICAL NAME
: Pyridine compd. with boron hydride
CAS REGISTRY NUMBER
: 110-51-0
LAST UPDATED
: 199709
DATA ITEMS CITED
: 5
MOLECULAR FORMULA
: C5-H8-B-N
MOLECULAR WEIGHT
: 92.95
WISWESSER LINE NOTATION : T6NJ XBHHHH
SYNONYMS/TRADE NAMES :
* Borane-pyridine (1:1)
* Boron, trihydro(pyridine)-, (T-4)* Pyridine, compd. with BH3 (1:1)
* Pyridine borane
* Pyridine, compd. with borane (1:1)
* Trihydro(pyridine)boron
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 95400 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
14KTAK "Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed.,
New
York, John Wiley & Sons, Inc., 1964 Volume(issue)/page/year: -,693,1964
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 64800 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
14KTAK "Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed.,
New
York, John Wiley & Sons, Inc., 1964 Volume(issue)/page/year: -,693,1964
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Administration onto the skin
Rodent - guinea pig
200 mg/kg
Details of toxic effects not reported other than lethal dose value
REFERENCE :
14KTAK "Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed.,
New
York, John Wiley & Sons, Inc., 1964 Volume(issue)/page/year: -,693,1964
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 54 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
14KTAK "Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed.,
New
York, John Wiley & Sons, Inc., 1964 Volume(issue)/page/year: -,693,1964
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BORAX
RTECS NUMBER
: ED4588000
CHEMICAL NAME
: Boric acid, disodium salt
CAS REGISTRY NUMBER
: 1330-43-4
OTHER CAS REGISTRY NOS. : 1332-28-1
LAST UPDATED
: 199907
DATA ITEMS CITED
: 17
MOLECULAR FORMULA
: B4-O7.2Na
MOLECULAR WEIGHT
: 201.22
COMPOUND DESCRIPTOR
: Reproductive Effector
SYNONYMS/TRADE NAMES :
* Anhydrous borax
* Borates, tetra, sodium salt, anhydrous
* Borax glass
* Disodium tetraborate
* FR 28
* Fused borax
* Rasorite 65
* Sodium biborate
* Sodium boron oxide
* Sodium tetraborate
* Sodium tetraborate (Na2B4O7)
*** HEALTH HAZARD DATA ***
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 26 gm/kg/14W-C
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation,
etc.)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
Biochemical - Metabolism (Intermediary) - xanthine, purine or nucleotides
including urate
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
10,219,1982
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 16750 ug/kg
SEX/DURATION
: male 30 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's
gland,
accessory glands
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 13,59,1976
*** REVIEWS ***
ACGIH TLV-TWA 1 mg/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 1 mg/m3 JAN 1993
OEL-BELGIUM:TWA 1 mg/m3 JAN 1993
OEL-DENMARK: TWA 1 mg/m3, JAN1999
OEL-THE NETHERLANDS:TWA 1 mg/m3 JAN 1993
OEL-SWITZERLAND:TWA 1 mg/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 1 mg/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - B0085
No. of Facilities: 1170 (estimated)
No. of Industries: 34
No. of Occupations: 27
No. of Employees: 5513 (estimated)
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M3899
No. of Facilities: 5 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 101 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M3899
No. of Facilities: 6225 (estimated)
No. of Industries: 87
No. of Occupations: 57
No. of Employees: 78116 (estimated)
No. of Female Employees: 15080 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
BORDEAUX R
RTECS NUMBER
CHEMICAL NAME
: QJ6479500
: 2,7-Naphthalenedisulfonic acid,
3-hydroxy-4-(1-naphthalenylazo)-, disodium salt
: 5858-33-3
: 199701
: 3
: C20-H14-N2-O7-S2.2Na
: 504.46
: Mutagen
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
* Acid Bordeaux
* Acid Bordeaux A
* Acid Bordeaux B
* Acid Bordeaux BN
* Acid Bordeaux MB
* Acid Red 17
* Acilan Bordeaux B
* Amacid Lake Bordeaux BL
* Azo Bordeaux
* Azo Bordeaux SS
* Bordeaux B
* Bordeaux R
* Bordeaux Red
* Bordeaux Red B
* Bordeaux R type 8019 for foods
* Brasilan Azo Bordeaux
* Brilliant Bordeaux B
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
Brilliant Bordeaux 2B
Brilliant Bordeaux 4B
Calcolake Bordeaux BXL
C.I. 16180
C.I. Acid Red 17
C.I. Acid Red 17, disodium salt
Colacid Bordeaux A
Eniacid Bordeaux BN
Hidacid Bordeaux B
Hispacid Bordeaux F
Java Bordeaux B
Kiton Bordeaux G
Lithosol Claret B
Naphthalene Bordeaux B
Naphthalene Bordeaux BS
Naphthalene Lake Bordeaux B
Naphthalene Leather Bordeaux B
Rouge Bordeaux B
Tertracid Bordeaux B
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M1430
No. of Facilities: 69 (estimated)
No. of Industries: 2
No. of Occupations: 14
No. of Employees: 1454 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BORIC ACID
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
OTHER CAS REGISTRY NOS.
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
* Basilit B
:
:
:
:
:
:
:
:
:
:
ED4550000
Boric acid
10043-35-3
12795-04-9
199904
62
B-H3-O3
61.84
QBQQ
Agricultural Chemical
Tumorigen
Drug
Mutagen
Reproductive Effector
Human
Primary Irritant
*
*
*
*
*
*
*
*
*
*
*
*
*
*
Boracic acid
Borofax
Boron trihydroxide
Borsaure
Dr.'s 1 Flea Terminator
Dr.'s 1 Flea Terminator
Dr.'s 1 Flea Terminator
Dr.'s 1 Flea Terminator
Flea Prufe
NCI-C56417
Orthoboric acid
Super Flea Eliminator
Three elephant
Trihydroxyborone
DF
DFPBO
DT
DTPBO
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Human
DOSE/DURATION
: 15 mg/3D (Intermittent)
REACTION SEVERITY
: Mild
REFERENCE :
85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976,"
Drill,
V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977
Volume(issue)/page/year: -,127,1977
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 429 mg/kg
TOXIC EFFECTS :
Cardiac - other changes
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
REFERENCE :
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270
Madison Ave., New York, NY 10016) V.191982Volume(issue)/page/year:
31,345,1993
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - child
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting
REFERENCE :
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270
Madison Ave., New York, NY 10016) V.191982Volume(issue)/page/year:
24,269,1986
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - woman
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Behavioral - fluid intake
Gastrointestinal - hypermotility, diarrhea
Gastrointestinal - nausea or vomiting
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.11823Volume(issue)/page/year: 2,162,1917
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - infant
DOSE/DURATION
: 800 mg/kg/4W-I
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Gastrointestinal - hypermotility, diarrhea
Gastrointestinal - nausea or vomiting
REFERENCE :
ADCHAK Archives of Disease in Childhood. (British Medical Journal, POB
560B, Kennebunkport, ME 04046) V.11926- Volume(issue)/page/year:
58,737,1983
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - infant
DOSE/DURATION
: 934 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N.
Dearborn St., Chicago, IL 60610) V.11883- Volume(issue)/page/year:
90,382,1928
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Human - infant
DOSE/DURATION
: 1200 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Skin and Appendages - dermatitis, other (after systemic exposure)
Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N.
Dearborn St., Chicago, IL 60610) V.11883- Volume(issue)/page/year:
129,332,1945
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Human - child
DOSE/DURATION
: 4 gm/kg/4D
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MMWOAU Muenchener Medicinische Wochenschrift. (Munich, Fed. Rep. Ger.)
V.33-115, 1886-1973. Volume(issue)/page/year: 52,763,1905
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 2430 mg/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea
Skin and Appendages - primary irritation (after topical exposure)
Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N.
Dearborn St., Chicago, IL 60610) V.11883- Volume(issue)/page/year:
128,266,1945
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Human - child
DOSE/DURATION
: 1500 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - conjunctive irritation
Lungs, Thorax, or Respiration - respiratory depression
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK)
V.2-21,
1929-48. For publisher information, see JPPMAB.
Volume(issue)/page/year:
6,714,1933
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Human - infant
DOSE/DURATION
: 1100 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Gastrointestinal - hypermotility, diarrhea
Gastrointestinal - nausea or vomiting
REFERENCE :
MDSR** U.S. Army, Chemical Corps Medical Division Special Report.
Chemical Center, MD) Volume(issue)/page/year: #2,1950
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 170 mg/kg
TOXIC EFFECTS :
Behavioral - wakefulness
Behavioral - anorexia (human)
Gastrointestinal - nausea or vomiting
REFERENCE :
RTPCAT Rassegna di Terapia e Patologia Clinica. (Rome, Italy)
1929-36. For publisher information, see RFCTAJ.
Volume(issue)/page/year:
1,472,1929
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LDLo - Lowest published lethal dose
Unreported
Human - man
147 mg/kg
(Army
V.1-8,
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena,
J.M.,
Springfield, IL, C.C. Thomas, 1970 Volume(issue)/page/year: 2,73,1970
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2660 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N.
Dearborn St., Chicago, IL 60610) V.11883- Volume(issue)/page/year:
128,266,1945
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 28 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,27,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1400 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
14KTAK "Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed.,
New
York, John Wiley & Sons, Inc., 1964 Volume(issue)/page/year: -,693,1964
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1330 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Gastrointestinal - hypermotility, diarrhea
Gastrointestinal - nausea or vomiting
REFERENCE :
MDSR** U.S. Army, Chemical Corps Medical Division Special Report.
Chemical Center, MD) Volume(issue)/page/year: #2,1950
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Oral
Rodent - mouse
3450 mg/kg
(Army
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N.
Dearborn St., Chicago, IL 60610) V.11883- Volume(issue)/page/year:
128,266,1945
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 800 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
14KTAK "Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed.,
New
York, John Wiley & Sons, Inc., 1964 Volume(issue)/page/year: -,693,1964
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1740 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N.
Dearborn St., Chicago, IL 60610) V.11883- Volume(issue)/page/year:
128,266,1945
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1240 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - respiratory depression
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.
(Williams
&
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
Volume(issue)/page/year: 134,117,1961
V.1-
1909/10-
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 1780 mg/kg
TOXIC EFFECTS :
Brain and Coverings - meningeal changes
Lungs, Thorax, or Respiration - cyanosis
Gastrointestinal - nausea or vomiting
REFERENCE :
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N.
Dearborn St., Chicago, IL 60610) V.11883- Volume(issue)/page/year:
128,266,1945
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 1 gm/kg
TOXIC EFFECTS :
Brain and Coverings - meningeal changes
Lungs, Thorax, or Respiration - cyanosis
Gastrointestinal - nausea or vomiting
REFERENCE :
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N.
Dearborn St., Chicago, IL 60610) V.11883- Volume(issue)/page/year:
128,266,1945
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 1 gm/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
REFERENCE :
RTPCAT Rassegna di Terapia e Patologia Clinica. (Rome, Italy) V.1-8,
1929-36. For publisher information, see RFCTAJ.
Volume(issue)/page/year:
1,472,1929
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 4 gm/kg
TOXIC EFFECTS :
Behavioral - tremor
Gastrointestinal - hypermotility, diarrhea
Gastrointestinal - nausea or vomiting
REFERENCE :
MDSR** U.S. Army, Chemical Corps Medical Division Special Report.
Chemical Center, MD) Volume(issue)/page/year: #2,1950
(Army
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden."
(Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 800 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
14KTAK "Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed.,
New
York, John Wiley & Sons, Inc., 1964
Volume(issue)/page/year: -,693,1964
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 670 mg/kg
TOXIC EFFECTS :
Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
RTPCAT Rassegna di Terapia e Patologia Clinica. (Rome, Italy)
1929-36. For publisher information, see RFCTAJ.
Volume(issue)/page/year:
1,472,1929
V.1-8,
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 1 gm/kg
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting
Gastrointestinal - other changes
REFERENCE :
RAMAAB Revista de la Asociacion Medica Argentina. (Buenos Aires,
Argentina)
V.1-89, 1915-76. Discontinued. Volume(issue)/page/year: 46,1493,1932
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 1200 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Gastrointestinal - hypermotility, diarrhea
Gastrointestinal - nausea or vomiting
REFERENCE :
MDSR** U.S. Army, Chemical Corps Medical Division Special Report.
Chemical Center, MD) Volume(issue)/page/year: #2,1950
(Army
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 45 gm/kg/90D-C
TOXIC EFFECTS :
Brain and Coverings - changes in brain weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - changes in testicular weight
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
23,351,1972
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 68 mg/kg/9W-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Nutritional and Gross Metabolic - changes in calcium
Nutritional and Gross Metabolic - changes in phosphorus
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 35,205,1997
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 42 gm/kg/14D-C
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-324,1987
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 156 gm/kg/13W-I
TOXIC EFFECTS :
Gastrointestinal - other changes
Blood - changes in spleen
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-324,1987
(Research
(Research
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 23 gm/kg/90D-C
TOXIC EFFECTS :
Liver - changes in liver weight
Endocrine - changes in thyroid weight
Related to Chronic Data - changes in testicular weight
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
23,351,1972
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 6600 mg/kg
SEX/DURATION
: female 1-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 18,266,1992
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 45 gm/kg
SEX/DURATION
: male 90 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
23,351,1972
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 5390 mg/kg
SEX/DURATION
: female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetal death
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 18,266,1992
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1596 mg/kg
SEX/DURATION
: female 0-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 32,179,1996
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 52 mg/kg
SEX/DURATION
: male 26 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972-
Volume(issue)/page/year: 13,69,1976
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 9600 ug/m3/4H
SEX/DURATION
: male 16 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic
material,
sperm morphology, motility, and count)
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 16(11),13,1972
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 7684 mg/kg
SEX/DURATION
: female 1-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 18,266,1992
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 17051 mg/kg
SEX/DURATION
: female 1-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 18,266,1992
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 18054 mg/kg
SEX/DURATION
: female 1-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 102(Suppl 7),107,1994
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 8136 mg/kg
SEX/DURATION
: female 1-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 102(Suppl 7),107,1994
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 3500 mg/kg
SEX/DURATION
: female 6-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
Reproductive - Specific Developmental Abnormalities - cardiovascular
(circulatory) system
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.11981- Volume(issue)/page/year: 12,103,1992
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 3500 mg/kg
SEX/DURATION
: female 6-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Fertility - litter size (e.g. # fetuses per litter;
measured
before birth)
Reproductive - Specific Developmental Abnormalities - cardiovascular
(circulatory) system
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 34,176,1996
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 3500 mg/kg
SEX/DURATION
: female 7-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972-
Volume(issue)/page/year: 102(Suppl 7),107,1994
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 3500 mg/kg
SEX/DURATION
: female 6-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB92-129550
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE
: 1750 mg/kg
SEX/DURATION
: female 7-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
Reproductive - Maternal Effects - other effects
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.11972Volume(issue)/page/year: 102(Suppl 7),107,1994
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 17000 ppm/24H
REFERENCE :
AMNTA4 American Naturalist. (Univ. of Chicago Press, Journals Div., POB
37005, Chicago, IL 60637) V.11867- Volume(issue)/page/year:
85,119,1951
*** REVIEWS ***
TOXICOLOGY REVIEW
CLCHAU Clinical Chemistry (Winston-Salem, NC). (American Assoc. for
Clinical Chemistry, 1725 K St., NW, Washington, DC 20006) V.11955Volume(issue)/page/year: 19,361,1973
TOXICOLOGY REVIEW
FNSCA6 Forensic Science.
(Lausanne, Switzerland)
V.1-11, 1972-78. For
pub
lisher information, see FSINDR.
Volume(issue)/page/year: 2,67,1973
TOXICOLOGY REVIEW
JOPDAB Journal of Pediatrics. (C.V. Mosby Co., 11830 Westline Industrial
Dr., St. Louis, MO 63141) V.11932- Volume(issue)/page/year:
61,531,1962
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 10 mg/m3 JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X7080
No. of Facilities: 27071 (estimated)
No. of Industries: 187
No. of Occupations: 128
No. of Employees: 489668 (estimated)
No. of Female Employees: 211838 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X8324
No. of Facilities: 84 (estimated)
No. of Industries: 3
No. of Occupations: 4
No. of Employees: 2919 (estimated)
No. of Female Employees: 1712 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NTP Carcinogenesis Studies (feed);no evidence:mouse
NTPTR* National Toxicology Program Technical Report Series.
Triangle Park, NC 27709) No.206- Volume(issue)/page/year:
NTP-TR-324,1987
BORIC ANHYDRIDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
* Boric anhydride
* Boron oxide
* Boron sesquioxide
:
:
:
:
:
:
:
:
:
ED7900000
Boron oxide
1303-86-2
199907
28
B2-O3
69.62
B2 O3
Primary Irritant
(Research
* Boron trioxide
* Diboron trioxide
* Fused boric acid
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1 gm
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
20,284,1959
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 50 mg
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
20,284,1959
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3163 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,27,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1868 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,27,1982
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: TCLo - Lowest published toxic concentration
: Inhalation
: Rodent - rat
DOSE/DURATION
: 77 mg/m3/6H/24W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - urine volume increased
Kidney, Ureter, Bladder - other changes in urine composition
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
20,284,1959
*** REVIEWS ***
ACGIH TLV-TWA 10 mg/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
MSHA STANDARD-air:TWA 10 mg/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,26,1971
OSHA PEL (Gen Indu):8H TWA 15 mg/m3, total dust
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 15 mg/m3, total dust
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 15 mg/m3, total dust
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Shipyard):8H TWA 5 mg/m3, respirable fraction
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 15 mg/m3
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
41,50-204.50,1994
(U.S. Government Printing Office,
Volume(issue)/page/year:
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRIA:TWA 15 mg/m3 JAN 1993
OEL-AUSTRIA: MAK 15 mg/m3, JAN1999
OEL-DENMARK: TWA 10 mg/m3, JAN1999
OEL-GERMANY:TWA 15 mg/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 10 mg/m3 JAN 1993
OEL-THE PHILIPPINES:TWA 15 mg/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 10 mg/m3;STEL 20 mg/m3 JAN 1993
OEL-POLAND: MAC(TWA) 10 mg/m3, JAN1999
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO BORON OXIDE, total dust-air:10H TWA 10 mg/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 12963
No. of Facilities: 2563 (estimated)
No. of Industries: 69
No. of Occupations: 49
No. of Employees: 15319 (estimated)
NOES - National Occupational
NOES Hazard Code - 12963
No. of Facilities: 10437
No. of Industries: 112
No. of Occupations: 78
No. of Employees: 162342
No. of Female Employees:
Exposure Survey (1983)
(estimated)
(estimated)
18457 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
BORNEOL (D-)
RTECS NUMBER
: ED7060000
CHEMICAL NAME
: Borneol, (1R,2S,4R)- (+)CAS REGISTRY NUMBER
: 464-43-7
BEILSTEIN REFERENCE NO. : 2038056
REFERENCE
: 4-06-00-00281 (Beilstein Handbook Reference)
LAST UPDATED
: 199612
DATA ITEMS CITED
: 1
MOLECULAR FORMULA
: C10-H18-O
MOLECULAR WEIGHT
: 154.28
SYNONYMS/TRADE NAMES :
* Bicyclo(2.2.1)heptan-2-ol, 1,7,7-trimethyl-, (1R-endo)* (+)-Borneol
* d-Borneol
* (1R-endo)-1,7,7-Trimethylbicyclo(2.2.1)heptan-2-ol
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and
Biologicals",
11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989
Volume(issue)/page/year:
11,204,1989
BORNEOL (DL-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
ED7000000
Borneol
507-70-0
199710
8
C10-H18-O
154.28
L55 ATJ A1 A1 B1 CQ
Mutagen
Natural Product
SYNONYMS/TRADE NAMES :
* 2-Bornanol, endo* Baros camphor
* Bhimsaim camphor
* Bicyclo(2.2.1)heptan-2-ol, 1,7,7-trimethyl-, endo* Borneo camphor
* trans-Borneol
* Bornyl alcohol
* Camphane, 2-hydroxy* 2-Camphanol
* Camphol
* Dryobalanops camphor
*
*
*
*
2-Hydroxycamphane
Malayan camphor
Sumatra camphor
1,7,7-Trimethyl-bicyclo(2.2.1)heptan-2-ol, endo*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRXXBL French Demande Patent Document. (U.S. Patent and Trademark
Office,
Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2448856
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1059 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SHGKA3 Shika Gakuho. Journal of Dentistry. (Tokyo Shika Daigaku Gakkai,
1-2-2 Masago, Chiba 260, Japan) V.11895- Volume(issue)/page/year:
75,934,1975
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RCTOE4 Reviews of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.981987- Volume(issue)/page/year: 113,47,1990
** MUTATION DATA **
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Bacillus subtilis
DOSE/DURATION
: 10 mg/disc
REFERENCE :
OIGZDE Osaka-shi Igakkai Zasshi. Journal of Osaka City Medical
Association.
(Osaka-shi Igakkai, c/o Osaka-shiritsu Daigaku Igakubu, 1-4-54
Asahi-cho,
Abeno-ku, Osaka, 545, Japan) V.241975- Volume(issue)/page/year:
34,267,1985
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M3906
No. of Facilities: 599 (estimated)
No. of Industries: 11
No. of Occupations: 24
No. of Employees: 6733 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M3906
No. of Facilities: 1731 (estimated)
No. of Industries: 12
No. of Occupations: 13
No. of Employees: 10168 (estimated)
No. of Female Employees: 1230 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
BORNEOL (ENDO-)
RTECS NUMBER
CHEMICAL NAME
: DT5095000
: Bicyclo(2.2.1)heptan-2-ol, 1,7,7-trimethyl-,
(1S-endo)CAS REGISTRY NUMBER
: 464-45-9
LAST UPDATED
: 199701
DATA ITEMS CITED
: 4
MOLECULAR FORMULA
: C10-H18-O
MOLECULAR WEIGHT
: 154.28
WISWESSER LINE NOTATION : L55 ATJ A1 A1 B1 CQ
COMPOUND DESCRIPTOR
: Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
* l-2-Bornanol
* (-)-Borneol
* l-Borneol
* Borneol, (1S,2R,4S)-(-)* 1-Bornyl alcohol
* l-2-Camphanol
* Linderol
* NGAI camphor
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg/24H
REACTION SEVERITY
: Mild
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK)
For
V.1-19, 1963-81.
publisher information, see FCTOD7.
Volume(issue)/page/year: 16,655,1978
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81.
For
publisher information, see FCTOD7. Volume(issue)/page/year: 16,655,1978
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; S
cerevisiae-homozygosis
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BORON
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
:
:
:
:
:
:
:
:
ED7350000
Boron
7440-42-8
199710
21
B
10.81
B
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 650 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 35(11),11,1970
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 7 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 35(2),42,1991
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 560 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 35(11),11,1970
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 11 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 35(2),42,1991
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 310 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 35(11),11,1970
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 35(11),11,1970
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 310 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 35(11),11,1970
(V/O
(V/O
(V/O
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 310 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 35(11),11,1970
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 40(9),49,1975
(V/O
(V/O
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 32 gm/kg/30D-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Cardiac - other changes
Liver - liver function tests impaired
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 35(2),42,1991
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 10560 ug/m3/4H/17W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 35(2),42,1991
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2821 mg/kg/13W-I
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other transferases
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 35(11),11,1970
*** REVIEWS ***
TOXICOLOGY REVIEW
KOTTAM Kogai to Taisaku. Journal of Environmental Pollution Control.
(Kogai
Taisaku Gijutsu Dokokai, Shuwa-Akasaka Bldg., 9-1-244, Akasaka,
Minato-ku,
Tokyo 107, Japan) V.11965- Volume(issue)/page/year: 11,1300,1975
TOXICOLOGY REVIEW
CLCHAU Clinical Chemistry (Winston-Salem, NC). (American Assoc. for
Clinical Chemistry, 1725 K St., NW, Washington, DC 20006) V.11955Volume(issue)/page/year: 19,361,1973
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 80251
No. of Facilities: 995 (estimated)
No. of Industries: 35
No. of Occupations: 31
No. of Employees: 6536 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4244
No. of Facilities: 3 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 65 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 80251
No. of Facilities: 2277 (estimated)
No. of Industries: 48
No. of Occupations: 74
No. of Employees: 41637 (estimated)
No. of Female Employees: 4576 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
BORON TRIBROMIDE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
SYNONYMS/TRADE NAMES :
* Borane, tribromo* Boron tribromide
* Tribromoborane
* Tribromoboron
:
:
:
:
:
:
:
ED7400000
Boron bromide
10294-33-4
199907
18
B-Br3
250.54
*** REVIEWS ***
ACGIH TLV-CL 10 mg/m3 (1 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 1 ppm (10 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,26,1971
OSHA PEL (Construc):8H TWA 1 ppm (10 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 1 ppm (10 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 1 ppm (10 mg/m3) JAN 1993
OEL-AUSTRIA: MAK 1 ppm (10 mg/m3), JAN1999
OEL-BELGIUM:STEL 1 ppm (10 mg/m3) JAN 1993
OEL-DENMARK: TWA 1 ppm (10 mg/m3), JAN1999
OEL-FINLAND:TWA 1 ppm (10 mg/m3);STEL 3 ppm (30 mg/m3) JAN 1993
OEL-THE NETHERLANDS:TWA 1 ppm (10 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 1 ppm (10 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 1 ppm (10 mg/m3);STEL 3 ppm (30 mg/m3) JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO BORON TRIBROMIDE-air:CL 1 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 12966
No. of Facilities: 11 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 335 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 12966
No. of Facilities: 32 (estimated)
No. of Industries: 4
No. of Occupations: 9
No. of Employees: 1554 (estimated)
No. of Female Employees: 878 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BRAZILIN
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
COMPOUND DESCRIPTOR
: DE3124000
: Benz(b)indeno(1,2-d)pyran-3,6a,9,10(6H)-tetrol,
7,11b-dihydro: 474-07-7
: 199701
: 2
: C16-H14-O5
: 286.30
: Drug
Natural Product
SYNONYMS/TRADE NAMES :
* Brasilin
* Braziletto
* Brazilin
* 7,11b-Dihydrobenz(b)indeno(1,2-d)pyran-3,6a,9,10(6H)-tetrol
* Hypernic extract
* Limawood extract
* Pernambuco extract
* Superbresiline
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca
Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 8(1),252,1982
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BREFELDIN A
RTECS NUMBER
CHEMICAL NAME
: GY8410000
: 4H-Cyclopent(f)oxacyclotridecin-4-one,
1,6,7,8,9,11a-beta,12,13,14,14a-alpha-decahydro-1beta-13-alpha-dihydroxy-6-beta-methylCAS REGISTRY NUMBER
: 20350-15-6
OTHER CAS REGISTRY NOS. : 3459-16-3
78206-62-9
LAST UPDATED
: 199412
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C16-H24-O4
MOLECULAR WEIGHT
: 280.40
WISWESSER LINE NOTATION : T5-13- IVO GU OUTJ CQ FQ K1
COMPOUND DESCRIPTOR
: Drug
Mutagen
SYNONYMS/TRADE NAMES :
* Ascotoxin
* Brefeldin A
* (+)-Brefeldin A
* Cyanaein
* Cyanein
* Decumbin
* Nectrolide
* Synergisidin
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Intraperitoneal
Rodent - mouse
250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research
Assoc.,
2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.211968Volume(issue)/page/year: 34,51,1981
** MUTATION DATA **
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Rodent - mouse Cells - not otherwise specified
DOSE/DURATION
: 200 ug/L
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc.,
2-20-8
Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968Volume(issue)/page/year: 39,1148,1986
BRIJ 35
RTECS NUMBER
: JR5960000
CHEMICAL NAME
: Dodecyl alcohol condensed with 4 moles ethylene
oxide
CAS REGISTRY NUMBER
: 9002-92-0
LAST UPDATED
: 199710
DATA ITEMS CITED
: 11
MOLECULAR FORMULA
: (C2-H4-O)n.C12-H26-O
WISWESSER LINE NOTATION : T3OTJ 4 &Q12
SYNONYMS/TRADE NAMES :
* BRIJ 30 P.O.E (4) lauryl ether
* Lauryl alcohol condensed with 4 moles ethylene oxide
* Lauryl alcohol EO (4)
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 8600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SPCOAH Soap, Perfumery & Cosmetics. (London, UK) V.8(7)-48(2), 1935-75.
Volume(issue)/page/year: 38,47,1965
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 954 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1-
1970Volume(issue)/page/year: 22,967,1991
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 27 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.11970Volume(issue)/page/year: 22,967,1991
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 4940 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APRCAS American Perfumer and Cosmetics. (Oak Park, IL) V.77-86,
1962-71.
For publisher information, see CSPEAX. Volume(issue)/page/year:
77,35,1962
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 160 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.11970Volume(issue)/page/year: 22,967,1991
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 792 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.11970Volume(issue)/page/year: 22,967,1991
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)
1970Volume(issue)/page/year: 22,967,1991
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - A1179
No. of Facilities: 3288 (estimated)
No. of Industries: 33
No. of Occupations: 37
No. of Employees: 43764 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - A1179
No. of Facilities: 5821 (estimated)
No. of Industries: 32
No. of Occupations: 40
No. of Employees: 104035 (estimated)
No. of Female Employees: 60645 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
BRIJ 52
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
SYNONYMS/TRADE NAMES :
* Atlas G 3802
* Atlas G 3816
* BC 7
* BC 10
* BC 20
* BC 20 TX
* BC 30 TX
* Berol 28
* BRIJ 38
* BRIJ 52
* BRIJ 56
* BRIJ 58
* BRIJ W1
* CA 16
* Ceteth
* Ceteth 1
* Ceteth 2
* Cetocire
: TR1581470
: Poly(oxy-1,2-ethanediyl),
alpha-hexadecyl-omega-hydroxy: 9004-95-9
: 199701
: 4
: (C2-H4-O)n-C16-H34-O
V.1-
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
Cetomacrogol 1000
Cetyl alcohol ethoxylate
Cetyl poly(oxyethylene) ether
Cirrasol ALN-WF
Collone AC
Emalex 103
Emalex 115
Emulgen 210
Ethosperse CL20
G 3802
G 3816
G 3820
Glycols, polyethylene, monohexadecyl ether
G 3802POE
G 3804POE
Hexadecylpoly(ethyleneoxy) ethanol
Lipocol C2
Lubrol W
Nikkol BC
Nikkol BC 30
Nikkol BC 40
Nikkol BC 15TX
Nikkol BC 20TX
Nissan nonion P 208
Nissan nonion P 210
Nissan nonion P 213
Nissan nonion P 220
Nonion P 208
Nonion P 210
NTS 40
OS 30
OS 55
OTsS 14
OTsS 20
Oxyethylenated hexadecyl alcohol
Polyethylene glycol cetyl ether
Polyethylene glycol palmityl ether
Polyethylene glycols monohexadecyl ether
Polyethylene oxide cetyl ether
Polyethylene oxide hexadecyl ether
Poly(oxyethylene)cetyl ether
Poly(oxyethylene)hexadecyl ether
Poly(oxyethylene)monocetyl ether
Poly(oxyethylene)palmityl ether
Romopal O
S 30
Ts 14
Ts 20
Ts 30
Ts 35
Ts 35 (polymer)
Ts 40
Ts 55
Ts 62
Ts A 16
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2602 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Lungs, Thorax, or Respiration - dyspnea
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
SRTCAC Science Reports of the Research Institutes, Tohoku University,
Series
C: Medicine. (Tohoku University, Research Institute for Tuberculosis and
Cancer, 4-1 Seiryo-machi, Sendai, Japan) V.11949Volume(issue)/page/year: 36(1-4),10,1989
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M2449
No. of Facilities: 42 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 1260 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X7468
No. of Facilities: 1599 (estimated)
No. of Industries: 11
No. of Occupations: 12
No. of Employees: 34643 (estimated)
No. of Female Employees: 14621 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BRILLIANT GREEN
RTECS NUMBER
CHEMICAL NAME
: BP6825000
: Ammonium,
(4-(p-(diethylamino)-alpha-phenylbenzylidene)-2,5-cyc
lohexadien-1-ylidene) diethyl-,sulfate (1:1)
CAS REGISTRY NUMBER
: 633-03-4
OTHER CAS REGISTRY NOS. : 56730-57-5
LAST UPDATED
: 199706
DATA ITEMS CITED
: 12
MOLECULAR FORMULA
: C27-H33-N2.H-O4-S
MOLECULAR WEIGHT
: 482.69
WISWESSER LINE NOTATION : L6Y DYJ AUYR&R DN2&2& DUK2&2 &Q &S-O4
COMPOUND DESCRIPTOR
: Drug
Mutagen
Primary Irritant
SYNONYMS/TRADE NAMES :
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
ADC Brilliant Green Crystals
Aizen Diamond Green GH
Aizen Malachite Green GH
Astra Diamond Green GX
Avon Green A-4379
Basic Bright Green
Basic Bright Green Sulfate
Basic Brilliant Green
Basic Green 1
Basic Green V
Brilliant Green
Brilliant Green Aseptic
Brilliant Green B
Brilliant Green B.P.
Brilliant Green BP Crystals
Brilliant Green BPC
Brilliant Green Crystals
Brilliant Green Crystals H
Brilliant Green DSC
Brilliant Green G
Brilliant Green GX
Brilliant Green Lake
Brilliant Green P
Brilliant Green Special
Brilliant Green Sulfate
Brilliant Green WP Crystals
Brilliant Green Y
Brilliant Green YN
Brilliant Green YNS
Brilliant-grun
Brilliant Lake Green Y
Brilliant Tungstate Green Toner GT-288
Calcozine Brilliant Green G
C.I. 42040
C.I. Basic Green 1
C.I. Basic Green 1, sulfate (1:1)
Deorlene Green JJO
Diamond Green G
Ethyl Green
Fast Green J
Fast Green JJO
12415 Green
Green EN
Hidaco Brilliant Green
Malachite Green G
Mitsui Brilliant Green GX
Solid Green
Tertrophene Brilliant Green G
Tokyo Aniline Brilliant Green
Zelen brilantni
Zelen malachitova G
Zelen smaragdova
Zelen zasadita 1
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Human
DOSE/DURATION
: 2 mg/2D (Intermittent)
REACTION SEVERITY
: Mild
REFERENCE :
ADVEA4 Acta Dermato-Venereologica. (Almqvist & Wiksell, POB 45150,
S-10430
Stockholm, Sweden) V.11920- Volume(issue)/page/year: 52,55,1972
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 6 mg/3D (Intermittent)
REFERENCE :
ADVEA4 Acta Dermato-Venereologica. (Almqvist & Wiksell, POB 45150,
S-10430
Stockholm, Sweden) V.11920- Volume(issue)/page/year: 52,55,1972
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 10 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - emphysema
Gastrointestinal - necrotic changes
Liver - other changes
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 7(2),54,1963
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 8 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - acute pulmonary edema
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.11903/04Volume(issue)/page/year: 31,825,1934
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 5 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - acute pulmonary edema
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.11903/04Volume(issue)/page/year: 31,825,1934
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - acute pulmonary edema
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.11903/04Volume(issue)/page/year: 31,825,1934
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 3 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - acute pulmonary edema
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.11903/04Volume(issue)/page/year: 31,825,1934
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 104 mg/m3/6W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 7(2),54,1963
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Yeast - Saccharomyces cerevisiae
DOSE/DURATION
: 100 ug/L
REFERENCE :
VINIT* Vsesoyuznyi Institut Nauchnoi i Tekhnicheskoi Informatsii
(VINITI).
All-Union Institute of Scientific and Technical Information. (Moscow,
USSR)
Use information broker to obtain publications. Volume(issue)/page/year:
#542-84
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M2187
No. of Facilities: 581 (estimated)
No. of Industries: 12
No. of Occupations: 14
No. of Employees: 7268 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M2187
No. of Facilities: 1486 (estimated)
No. of Industries: 16
No. of Occupations: 22
No. of Employees: 43142 (estimated)
No. of Female Employees: 29395 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BROMCRESOL GREEN
RTECS NUMBER
CHEMICAL NAME
: SJ7456000
: Phenol,
4,4'-(3H-2,1-benzoxathiol-3-ylidene)bis(2,6-dibromo-3
-methyl-, S,S-dioxide
CAS REGISTRY NUMBER
: 76-60-8
OTHER CAS REGISTRY NOS. : 641-19-0
BEILSTEIN REFERENCE NO. : 0372527
REFERENCE
: 5-19-03-00460 (Beilstein Handbook Reference)
LAST UPDATED
: 199906
DATA ITEMS CITED
: 4
MOLECULAR FORMULA
: C21-H14-Br4-O5-S
MOLECULAR WEIGHT
: 698.05
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* BCG
* Bromocresol Green
* m-Cresol, 4,4'-(3H-2,1-benzoxathiol-3-ylidene)bis(2,6-dibromo-,
S,S-dioxide
* Tetrabromo-m-cresolphthalein sulfone
* 3',3'',5',5''-Tetrabromo-m-cresolsulfonephthalein
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 81325
No. of Facilities: 192 (estimated)
No. of Industries: 12
No. of Occupations: 10
No. of Employees: 925 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 81325
No. of Facilities: 835 (estimated)
No. of Industries: 14
No. of Occupations: 13
No. of Employees: 14538 (estimated)
No. of Female Employees: 9176 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; Histidine
reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BROMINE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
* Brom
* Brome
* Bromine
* Bromo
* Broom
* Dibromine
:
:
:
:
:
:
:
:
:
EF9100000
Bromine
7726-95-6
199907
52
Br2
159.82
E2
Human
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human
DOSE/DURATION
: 14 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
Academic Press, Inc., 1969 Volume(issue)/page/year: -,645,1969
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 1000 ppm
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
Academic Press, Inc., 1969 Volume(issue)/page/year: -,645,1969
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Oral
Rodent - rat
2600 mg/kg
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 35(11),11,1970
(V/O
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2700 mg/m3
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 20(3),36,1976
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 35(11),11,1970
(V/O
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 750 ppm/9M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
39,129,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 4160 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 35(11),11,1970
(V/O
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 180 ppm/6.5H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders
Co.,
1956-59
Volume(issue)/page/year: 1,324,1955
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 5500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 35(11),11,1970
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 440 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 39(4),86,1974
(V/O
(V/O
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1400 ug/m3/17W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory depression
Endocrine - evidence of thyroid hypofunction
Endocrine - changes in thyroid weight
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 20(3),36,1976
*** REVIEWS ***
ACGIH TLV-STEL 1.3 mg/m3 (0.2 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 0.66 mg/m3 (0.1 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
TOXICOLOGY REVIEW
KOTTAM Kogai to Taisaku. Journal of Environmental Pollution Control.
(Kogai
Taisaku Gijutsu Dokokai, Shuwa-Akasaka Bldg., 9-1-244, Akasaka,
Minato-ku,
Tokyo 107, Japan)
V.1-
1965-
Volume(issue)/page/year: 11,1300,1975
TOXICOLOGY REVIEW
FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher
information, see JFDSAZ. Volume(issue)/page/year: 7,313,1942
TOXICOLOGY REVIEW
CLCHAU Clinical Chemistry (Winston-Salem, NC). (American Assoc. for
Clinical Chemistry, 1725 K St., NW, Washington, DC 20006) V.11955Volume(issue)/page/year: 19,361,1973
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
MSHA STANDARD-air:TWA 0.1 ppm (0.7 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,27,1971
OSHA PEL (Gen Indu):8H TWA 0.1 ppm (0.7 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 0.1 ppm (0.7 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 0.1 ppm (0.7 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 0.1 ppm (0.7 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 0.1 ppm (0.7 mg/m3) JAN 1993
OEL-AUSTRIA: MAK 0.1 ppm (0.7 mg/m3), JAN1999
OEL-AUSTRALIA:TWA 0.1 ppm (0.7 mg/m3);STEL 0.3 ppm (2 mg/m3) JAN 1993
OEL-AUSTRIA:TWA 0.1 ppm (0.7 mg/m3) JAN 1993
OEL-DENMARK: TWA 0.1 ppm (0.7 mg/m3), JAN1999
OEL-BELGIUM:TWA 0.1 ppm (0.66 mg/m3);STEL 0.3 ppm (2 mg/m3) JAN 1993
OEL-FINLAND:STEL 0.1 ppm (0.7 mg/m3);Skin JAN 1993
OEL-JAPAN: OEL 0.1 ppm (0.65 mg/m3), JAN1999
OEL-GERMANY:TWA 0.1 ppm (0.7 mg/m3) JAN 1993
OEL-HUNGARY:STEL 0.7 mg/m3;Skin JAN 1993
OEL-POLAND: MAC(TWA) 0.7 mg/m3, STEL 2 mg/m3, JAN1999
OEL-INDIA:TWA 0.1 ppm (0.7 mg/m3);STEL 0.3 ppm (2 mg/m3) JAN 1993
OEL-JAPAN:TWA 0.1 ppm (0.65 mg/m3) JAN 1993
OEL-THE NETHERLANDS:TWA 0.1 ppm (0.7 mg/m3) JAN 1993
OEL-THE PHILIPPINES:TWA 0.1 ppm (0.7 mg/m3) JAN 1993
OEL-RUSSIA:TWA 0.1 ppm;STEL 0.5 mg/m3 JAN 1993
OEL-SWEDEN:TWA 0.1 ppm (0.7 mg/m3);STEL 0.3 ppm (2 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 0.1 ppm (0.7 mg/m3);STEL 0.2 ppm (1.4 mg/m3) JAN 1993
OEL-TURKEY:TWA 0.1 ppm (0.7 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 0.1 ppm (0.7 mg/m3);STEL 0.3 ppm JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO BROMINE-air:10H TWA 0.1 ppm;STEL 0.3 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 13100
No. of Facilities: 583 (estimated)
No. of Industries: 17
No. of Occupations: 16
No. of Employees: 23977 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 13100
No. of Facilities: 1679 (estimated)
No. of Industries: 40
No. of Occupations: 55
No. of Employees: 62214 (estimated)
No. of Female Employees: 10780 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Bromine and chlorine, 6011
OSHA ANALYTICAL METHOD #ID-108
BROMOACETAMIDE (2-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
SYNONYMS/TRADE NAMES :
* Bromoacetamide
* 2-Bromoacetamide
:
:
:
:
:
:
:
:
:
:
AB4587000
Acetamide, 2-bromo683-57-8
1739073
4-02-00-00530 (Beilstein Handbook Reference)
199612
3
C2-H4-Br-N-O
137.98
ZV1E
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 124 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International
Book
Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23,
1978-88.
For
publisher information, see ZYZAEU. Volume(issue)/page/year:
16(8),54,1981
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: >102 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International
Book
Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23,
1978-88.
For
publisher information, see ZYZAEU.
16(8),54,1981
Volume(issue)/page/year:
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 61 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International
Book
Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23,
1978-88.
For
publisher information, see ZYZAEU. Volume(issue)/page/year:
16(8),54,1981
BROMOACETANILIDE (4'-)
RTECS NUMBER
: AD9625000
CHEMICAL NAME
: Acetanilide, 4'-bromoCAS REGISTRY NUMBER
: 103-88-8
BEILSTEIN REFERENCE NO. : 2208091
REFERENCE
: 4-12-00-01504 (Beilstein Handbook Reference)
LAST UPDATED
: 199701
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C8-H8-Br-N-O
MOLECULAR WEIGHT
: 214.08
WISWESSER LINE NOTATION : ER DMV1
SYNONYMS/TRADE NAMES :
* Acetamide, N-(4-bromophenyl)* Acetanilide, p-bromo* Antisepsin
* Asepsin
* p-Bromoacetanilide
* 4-Bromoacetanilide
* 4'-Bromoacetanilide
* p-Bromo-N-acetanilide
* Bromoanilide
* Bromoantifebrin
* USAF DO-40
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCNSA6 National Academy of Sciences, National Research Council,
Chemical-Biological Coordination Center, Review. (Washington, DC)
Volume(issue)/page/year: 5,10,1953
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD277-689
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BROMOACETIC ACID
RTECS NUMBER
: AF5950000
CHEMICAL NAME
: Acetic acid, bromoCAS REGISTRY NUMBER
: 79-08-3
BEILSTEIN REFERENCE NO. : 0506167
REFERENCE
: 4-02-00-00526 (Beilstein Handbook Reference)
LAST UPDATED
: 199710
DATA ITEMS CITED
: 18
MOLECULAR FORMULA
: C2-H3-Br-O2
MOLECULAR WEIGHT
: 138.96
WISWESSER LINE NOTATION : QV1E
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Acide bromacetique
* Bromoacetate ion
* Bromoacetic acid
* alpha-Bromoacetic acid
* Bromoethanoic acid
* alpha-Bromoethanoic acid
* Kyselina bromoctova
* Monobromessigsaeure
* Monobromoacetic acid
* To NTU
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 50 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - rigidity (including catalepsy)
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0555280
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 114 gm/m3/30M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RPTOAN Russian Pharmacology and Toxicology (English Translation).
Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton,
Surrey,
UK) V.301967- Volume(issue)/page/year: 41,113,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EPASR* United States Environmental Protection Agency, Office of
Pesticides
and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St.,
SW,
Washington, DC 20460) History unknown. Volume(issue)/page/year:
8EHQ-0191-1149S
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RPTOAN Russian Pharmacology and Toxicology (English Translation).
Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton,
Surrey,
UK) V.301967- Volume(issue)/page/year: 41,113,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EPASR* United States Environmental Protection Agency, Office of
Pesticides
and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St.,
SW,
Washington, DC 20460) History unknown. Volume(issue)/page/year:
8EHQ-0391-1149
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LD50 - Lethal dose, 50 percent kill
: Intraperitoneal
: Rodent - mouse
DOSE/DURATION
: 66 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
REFERENCE :
JNCIAM Journal of the National Cancer Institute.
V.1-60,
1940-78. For publisher information, see JJIND8.
Volume(issue)/page/year:
31,297,1963
(Washington, DC)
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: >48 mg/kg
TOXIC EFFECTS :
Behavioral - ataxia
Gastrointestinal - hypermotility, diarrhea
Gastrointestinal - nausea or vomiting
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark)
V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
11,33,1955
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: >24 mg/kg
TOXIC EFFECTS :
Cardiac - EKG changes not diagnostic of specified effects
Behavioral - ataxia
Behavioral - somnolence (general depressed activity)
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark)
V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
11,33,1955
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 59900 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0555280
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 45 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - rigidity (including catalepsy)
Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 160,551,1931
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0555280
** MUTATION DATA **
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - mouse Leukocyte
DOSE/DURATION
: 100 umol/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11958Volume(issue)/page/year:
30,1497,1981
*** REVIEWS ***
TOXICOLOGY REVIEW
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark)
V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
11,13,1955
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83731
No. of Facilities: 14 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 42 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 83731
No. of Facilities: 784 (estimated)
No. of Industries: 6
No. of Occupations: 6
No. of Employees: 4874 (estimated)
No. of Female Employees: 249 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
BROMOACETONITRILE
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
BEILSTEIN REFERENCE NO. :
REFERENCE
:
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
COMPOUND DESCRIPTOR
:
SYNONYMS/TRADE NAMES :
* Bromoacetonitrile
* Bromomethyl cyanide
* Cyanomethyl bromide
AL7970000
Acetonitrile, bromo590-17-0
0956569
4-02-00-00531 (Beilstein Handbook Reference)
199612
3
C2-H2-Br-N
119.96
Mutagen
*** HEALTH HAZARD DATA ***
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 6 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
341,289,1995
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Multiple routes
TEST SYSTEM
: Non-mammalian species
DOSE/DURATION
: 125 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
341,289,1995
TYPE OF TEST
: Unscheduled DNA synthesis
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 19350 ug/kg
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.11981- Volume(issue)/page/year: 13,220,1993
BROMOANILINE (4-)
RTECS NUMBER
: BW9280000
CHEMICAL NAME
: Aniline, p-bromoCAS REGISTRY NUMBER
: 106-40-1
BEILSTEIN REFERENCE NO. : 0742031
REFERENCE
: 4-12-00-01497 (Beilstein Handbook Reference)
LAST UPDATED
: 199710
DATA ITEMS CITED
: 11
MOLECULAR FORMULA
: C6-H6-Br-N
MOLECULAR WEIGHT
: 172.04
WISWESSER LINE NOTATION : ZR DE
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Benzenamine, 4-bromo* 4-Bromanilinu
* p-Bromoaniline
* 4-Bromoaniline
* 4-Bromobenzenamine
* p-Bromophenylamine
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 456 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CEHYAN Ceskoslovenska Hygiena. Czechoslovak Hygiene. (PNS-Ustredni
Expedice a Dovoz Tisku, Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.11956- Volume(issue)/page/year: 23,168,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 289 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 44(12),19,1979
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 248 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 44(12),19,1979
(V/O
(V/O
** MUTATION DATA **
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 50 umol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 3,11,1981
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M2753
No. of Facilities: 174 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 1744 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M2753
No. of Facilities: 184 (estimated)
No. of Industries: 3
No. of Occupations: 6
No. of Employees: 4703 (estimated)
No. of Female Employees: 3745 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
47,26992,82
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
BROMOBENZALDEHYDE (4-)
RTECS NUMBER
: CU4810000
CHEMICAL NAME
: Benzaldehyde, p-bromoCAS REGISTRY NUMBER
: 1122-91-4
LAST UPDATED
: 199701
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C7-H5-Br-O
MOLECULAR WEIGHT
: 185.03
WISWESSER LINE NOTATION : VHR DE
SYNONYMS/TRADE NAMES :
* Benzaldehyde, 4-bromo* p-Bromobenzaldehyde
* 4-Bromobenzaldehyde
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Oral
Rodent - mouse
1230 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 44(12),19,1979
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 389 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 44(12),19,1979
(V/O
(V/O
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BROMOBENZENE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
* Monobromobenzene
* NCI-C55492
* Phenyl bromide
:
:
:
:
:
:
:
:
:
CY9000000
Benzene, bromo108-86-1
199812
25
C6-H5-Br
157.02
ER
Mutagen
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2383 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - chromodacryorrhea
Gastrointestinal - hypermotility, diarrhea
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0571670
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 20411 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 19(9),36,1975
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3882 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
83,108,1986
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2700 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - muscle contraction or spasticity
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 13(9),56,1969
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 21 gm/m3/2H
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - muscle contraction or spasticity
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 13(9),56,1969
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 817 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year:
2,111,1987
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2 gm/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Lungs, Thorax, or Respiration - respiratory stimulation
Lungs, Thorax, or Respiration - other changes
REFERENCE :
JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc.,
c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku,
Kyoto
606, Japan) V.11951- Volume(issue)/page/year: 3,99,1954
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 3300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,28,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 1700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,28,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 2700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 32(10),25,1988
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 14400 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 18(4),55,1974
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3768 mg/kg/18D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 21,325,1987
** MUTATION DATA **
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 250 mg/L
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 62,873,1979
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 125 mg/kg/24H
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year:
2,111,1987
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 500 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
10(Suppl 10),1,1987
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-HUNGARY:TWA 3 mg/m3;STEL 6 mg/m3;Skin JAN 1993
OEL-RUSSIA:STEL 3 mg/m3 JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83863
No. of Facilities: 105 (estimated)
No. of Industries: 5
No. of Occupations: 9
No. of Employees: 18936 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 83863
No. of Facilities: 64 (estimated)
No. of Industries: 2
No. of Occupations: 3
No. of Employees: 1891 (estimated)
No. of Female Employees: 238 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: SHE-clonal assay; Host-mediated assay
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; S
cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
BROMOBENZOIC ACID (2-)
RTECS NUMBER
: DG4448035
CHEMICAL NAME
: Benzoic acid, o-bromoCAS REGISTRY NUMBER
: 88-65-3
BEILSTEIN REFERENCE NO. : 0971266
REFERENCE
: 4-27-00-07537 (Beilstein Handbook Reference)
LAST UPDATED
: 199710
DATA ITEMS CITED
: 4
MOLECULAR FORMULA
: C7-H5-Br-O2
MOLECULAR WEIGHT
: 201.03
SYNONYMS/TRADE NAMES :
* Benzoic acid, 2-bromo* o-Bromobenzoic acid
* 2-Bromobenzoic acid
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCNSA6 National Academy of Sciences, National Research Council,
Chemical-Biological Coordination Center, Review. (Washington, DC)
Volume(issue)/page/year: 5,7,1953
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
BROMOBENZOIC ACID (4-)
RTECS NUMBER
: DG4448050
CHEMICAL NAME
: Benzoic acid, p-bromoCAS REGISTRY NUMBER
: 586-76-5
BEILSTEIN REFERENCE NO. : 1906923
REFERENCE
: 4-09-00-01017 (Beilstein Handbook Reference)
LAST UPDATED
: 199710
DATA ITEMS CITED
: 5
MOLECULAR FORMULA
: C7-H5-Br-O2
MOLECULAR WEIGHT
: 201.03
WISWESSER LINE NOTATION : QVR DE
SYNONYMS/TRADE NAMES :
* Benzoic acid, 4-bromo* p-Bromobenzenecarboxylic acid
* p-Bromobenzoic acid
* 4-Bromobenzoic acid
* p-Carboxybromobenzene
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1059 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936Volume(issue)/page/year: 44(12),19,1979
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 536 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV.
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.11936-
(V/O
(V/O
Volume(issue)/page/year: 44(12),19,1979
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
BROMOBENZONITRILE (4-)
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
WISWESSER LINE NOTATION :
COMPOUND DESCRIPTOR
:
SYNONYMS/TRADE NAMES :
* 4-Bromobenzonitrile
DI2460000
Benzonitrile, 4-bromo623-00-7
199007
2
C7-H4-Br-N
182.03
NCR DE
Drug
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 237 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington,
DC
20037) V.61963- Volume(issue)/page/year: 21,906,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia,
Italy) V.8-43 1953-88 For publisher information, see FRMCE8
Volume(issue)/page/year: 41,41,1986
BROMOBENZOYL CHLORIDE (2-)
RTECS NUMBER
: DM6635000
CHEMICAL NAME
: Benzoyl chloride, o-bromoCAS REGISTRY NUMBER
: 7154-66-7
BEILSTEIN REFERENCE NO. : 0508506
REFERENCE
: 4-09-00-01013 (Beilstein Handbook Reference)
LAST UPDATED
: 199612
DATA ITEMS CITED
: 1
MOLECULAR FORMULA
: C7-H4-Br-Cl-O
MOLECULAR WEIGHT
: 219.47
WISWESSER LINE NOTATION : GVR BE
SYNONYMS/TRADE NAMES :
* 2-Bromobenzoyl chloride
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 56 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD
21010)
Volume(issue)/page/year: NX#00244
BROMOBUTANE (1-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
* 1-Bromobutane
* 1-Butyl bromide
:
:
:
:
:
:
:
:
:
EJ6225000
Butane, 1-bromo109-65-9
199710
9
C4-H9-Br
137.04
E4
Mutagen
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4450 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPCEAO Journal fuer Praktische Chemie. (Johann Ambrosius Barth Verlag,
Postfach 109, Leipzig DDR-7010, Ger. Dem. Rep.) V.11834-
Volume(issue)/page/year: 320,133,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1424 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 20(12),52,1976
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 25800 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 18(4),55,1974
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 0.3 mg/m3;Skin JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X7278
No. of Facilities: 7 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 1822 (estimated)
No. of Female Employees: 272 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
BROMOBUTANE (2-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
: EJ6228000
: Butane, 2-bromo: 78-76-2
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
0505949
0-01-00-00119 (Beilstein Handbook Reference)
199710
4
C4-H9-Br
137.04
EY2&1
Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* sec-Butyl bromide
* 2-Butyl bromide
* Methylethylbromomethane
*** HEALTH HAZARD DATA ***
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3000 mg/kg/8W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
35,1411,1975
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
BROMOBUTANONE (1:2-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
SYNONYMS/TRADE NAMES :
* 1-Bromo-2-butanone
* TL 819
:
:
:
:
:
:
:
:
:
:
EL7000000
2-Butanone, 1-bromo816-40-0
0741894
4-01-00-03258 (Beilstein Handbook Reference)
199612
1
C4-H7-Br-O
151.02
E1V2
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 500 mg/m3/10M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NDRC** National Defense Research Committee, Office of Scientific Research
and Development, Progress Report. Volume(issue)/page/year:
No.9-4-1-9,1943
BROMOCAMPHOR (ENDO,3-)
RTECS NUMBER
: DT5095100
CHEMICAL NAME
: Bicyclo(2.2.1)heptan-2-one,
3-bromo-1,7,7-trimethylCAS REGISTRY NUMBER
: 76-29-9
LAST UPDATED
: 199701
DATA ITEMS CITED
: 4
MOLECULAR FORMULA
: C10-H15-Br-O
MOLECULAR WEIGHT
: 231.16
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
* 2-Bornanone, 3-bromo* 3-Bromocamphor
* 3-Bromo-1,7,7-trimethylbicyclo(2.2.1)heptan-2-one
* Camphor bromide
* Camphor, 3-bromo*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4450 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis)
REFERENCE :
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow,
101479,
Russia) History Unknown Volume(issue)/page/year: (2),25,1994
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3500 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow,
101479,
Russia) History Unknown Volume(issue)/page/year: (2),25,1994
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 152 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow,
101479,
Russia) History Unknown Volume(issue)/page/year: (2),25,1994
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BROMOCHLOROACETOPHENONE
RTECS NUMBER
: AM5978800
CHEMICAL NAME
: Acetophenone, 2-bromo-4'-chloroCAS REGISTRY NUMBER
: 536-38-9
BEILSTEIN REFERENCE NO. : 0607603
REFERENCE
: 4-07-00-00651 (Beilstein Handbook Reference)
LAST UPDATED
: 199709
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C8-H6-Br-Cl-O
MOLECULAR WEIGHT
: 233.50
COMPOUND DESCRIPTOR
: Drug
SYNONYMS/TRADE NAMES :
* p-(Bromoacetyl)chlorobenzene
* Bromomethyl p-chlorophenyl ketone
* p-Chlorophenacyl bromide
* 4'-Chlorophenacyl bromide
* Ethanone, 2-bromo-1-(4-chlorophenyl)*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MEXPAG Medicina Experimentalis. (Basel, Switzerland) V.1-11, 1959-64;
V.18-19, 1968-69. For publisher information, see JNMDBO.
Volume(issue)/page/year: 11,137,1964
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BROMOCHLOROBENZENE (1,4-)
RTECS NUMBER
: CY9006000
CHEMICAL NAME
: Benzene, 1-bromo-4-chloroCAS REGISTRY NUMBER
: 106-39-8
LAST UPDATED
: 199710
DATA ITEMS CITED
: 3
MOLECULAR FORMULA
: C6-H4-Br-Cl
MOLECULAR WEIGHT
: 191.46
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* p-Bromochlorobenzene
* 4-Bromochlorobenzene
* p-Bromophenyl chloride
* p-Chlorobromobenzene
* 1-Chloro-4-bromobenzene
* 4-Chloro-1-bromobenzene
* 4-Chlorobromobenzene
* p-Chlorophenyl bromide
* 4-Chlorophenyl bromide
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; S
cerevisiae-homozygosis
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
BROMOCHLOROETHANE (1,2-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
KH6500000
Ethane, 1-bromo-2-chloro107-04-0
0605265
4-01-00-00155 (Beilstein Handbook Reference)
199710
14
C2-H4-Br-Cl
143.42
G2E
Agricultural Chemical
Mutagen
SYNONYMS/TRADE NAMES :
* 1-Bromo-2-chloroethane
* 2-Bromoethyl chloride
* sym-Chlorobromoethane
* 1-Chloro-2-bromoethane
* 2-Chloroethyl bromide
* Ethylene chlorobromide
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 64 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College
Science Pub., 1969 Volume(issue)/page/year: 4,73,1969
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 1 mmol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 2,499,1981
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 10 mg/plate
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
34,2576,1974
TYPE OF TEST
: Specific locus test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 1 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
285,209,1993
TYPE OF TEST
: Specific locus test
ROUTE OF EXPOSURE
: Inhalation
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 7 ppm
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
285,209,1993
TYPE OF TEST
: Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 1 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
285,209,1993
TYPE OF TEST
: DNA damage
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 500 umol/kg
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.11980Volume(issue)/page/year: 4,1491,1983
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 400 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
90,183,1981
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 4 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
90,183,1981
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9
EPA GENETOX PROGRAM 1988, Positive: CHO gene mutation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
BROMOCHLOROMETHANE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
* Chlorobromomethane
* Halon 1011
:
:
:
:
:
:
:
:
:
:
:
PA5250000
Methane, bromochloro74-97-5
1730801
4-01-00-00074 (Beilstein Handbook Reference)
199907
41
C-H2-Br-Cl
129.39
G1E
Drug
Mutagen
* Methylene chlorobromide
* Mil-B-4394-B
* Mono-chloro-mono-bromo-methane
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
Academic Press, Inc., 1969 Volume(issue)/page/year: -,390,1969
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 28800 ppm/15M
TOXIC EFFECTS :
Behavioral - general anesthetic
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - tremor
REFERENCE :
MRLR** U.S. Army, Chemical Corps Medical Laboratories Research Reports.
(Army Chemical Center, Edgewood Arsenal, MD) Volume(issue)/page/year:
#113,1952
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 4300 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 29,382,1947
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 12030 mg/m3/7H
TOXIC EFFECTS :
Behavioral - general anesthetic
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 29,382,1947
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Administration onto the skin
Rodent - rabbit
>20 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD-A062-138
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1000 ppm/7H/16W-I
TOXIC EFFECTS :
Liver - fatty liver degeneration
Kidney, Ureter, Bladder - changes in bladder weight
Nutritional and Gross Metabolic - changes in metals, not otherwise
specified
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
21,275,1960
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 500 ppm/6H/26W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Nutritional and Gross Metabolic - changes in metals, not otherwise
specified
REFERENCE :
JOCMA7 Journal of Occupational Medicine. (Chicago, IL) V.1-9,
1957-67.
For publisher information, see:JJOMDZ Volume(issue)/page/year:
8,251,1966
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 500 ppm/6H/26W-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - changes in metals, not otherwise
specified
REFERENCE :
JOCMA7 Journal of Occupational Medicine. (Chicago, IL) V.1-9,
1957-67.
For publisher information, see:JJOMDZ Volume(issue)/page/year:
8,251,1966
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1000 ppm/7H/16W-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - changes in metals, not otherwise
specified
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
21,275,1960
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 10 mg/plate
REFERENCE :
DHEFDK HEW Publication (FDA. United States). (Washington, DC)
?-1979(?).
For publisher information, see HPFSDS. Volume(issue)/page/year:
FDA-78-1046,1978
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 10 ug/plate
REFERENCE :
TECSDY Toxicological and Environmental Chemistry. (Gordon & Breach
Science
Pub. Inc., 1 Park Ave., New York, NY 10016) V.3(3/4)1981Volume(issue)/page/year: 13,205,1987
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 1 umol/L
REFERENCE :
TECSDY Toxicological and Environmental Chemistry. (Gordon & Breach
Science
Pub. Inc., 1 Park Ave., New York, NY 10016) V.3(3/4)1981Volume(issue)/page/year: 13,205,1987
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 5 umol/L
REFERENCE :
TECSDY Toxicological and Environmental Chemistry. (Gordon & Breach
Science
Pub. Inc., 1 Park Ave., New York, NY 10016) V.3(3/4)1981Volume(issue)/page/year: 13,205,1987
*** REVIEWS ***
ACGIH TLV-TWA 1060 mg/m3 (200 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 200 ppm (1050 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,50,1971
OSHA PEL (Gen Indu):8H TWA 200 ppm (1050 mg/m3)
CFRGBR Code of Federal Regulations.
Supt.
of Documents, Washington, DC 20402)
29,1910.1000,1994
(U.S. Government Printing Office,
Volume(issue)/page/year:
OSHA PEL (Construc):8H TWA 200 ppm (1050 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 200 ppm (1050 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 200 ppm (1050 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 200 ppm (1050 mg/m3);STEL 250 ppm (1300 mg/m3) JAN 1993
OEL-AUSTRIA: MAK 200 ppm (1050 mg/m3), JAN1999
OEL-AUSTRIA:TWA 200 ppm (1050 mg/m3) JAN 1993
OEL-DENMARK: TWA 200 ppm (1050 mg/m3), JAN1999
OEL-FINLAND:TWA 200 ppm (1050 mg/m3);STEL 250 ppm (1315 mg/m3) JAN 1993
OEL-GERMANY:TWA 200 ppm (1050 mg/m3) JAN 1993
OEL-THE NETHERLANDS:TWA 200 ppm (1050 mg/m3) JAN 1993
OEL-THE PHILIPPINES:TWA 200 ppm (1050 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 200 ppm (1050 mg/m3);STEL 400 ppm JAN 1993
OEL-POLAND: MAC(TWA) 1000 mg/m3, STEL 1300 mg/m3, JAN1999
OEL-TURKEY:TWA 200 ppm (1050 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 200 ppm (1050 mg/m3);STEL 250 ppm JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO CHLOROBROMOMETHANE-air:10H TWA 200 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 18250
No. of Facilities: 7 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 56 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 18250
No. of Facilities: 35 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 71 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Hydrocarbons, halogenated, 1003
BROMOCHLOROPROPANE (1,3-)
RTECS NUMBER
: TX4113000
CHEMICAL NAME
: Propane, 1-bromo-3-chloroCAS REGISTRY NUMBER
: 109-70-6
BEILSTEIN REFERENCE NO. : 0605278
REFERENCE
: 4-01-00-00212 (Beilstein Handbook Reference)
LAST UPDATED
: 199710
DATA ITEMS CITED
: 8
MOLECULAR FORMULA
: C3-H6-Br-Cl
MOLECULAR WEIGHT
: 157.45
WISWESSER LINE NOTATION : G3E
SYNONYMS/TRADE NAMES :
* 1-Bromo-3-chloropropane
* 3-Bromopropyl chloride
* 1,3-Chbp
* omega-Chlorobromopropane
* 3-Chloropropyl bromide
* Trimethylene bromide chloride
* Trimethylene chlorobromide
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 930 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - excitement
Behavioral - muscle weakness
REFERENCE :
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.
Toxicology of New Industrial Chemical Substances. For English
translation,
see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.11961Volume(issue)/page/year: 12,93,1971
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5668 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 19(9),36,1975
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1290 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,35,1982
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 7270 mg/m3/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under
Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International
Projects,
GKNT, 1982 Volume(issue)/page/year: -,35,1982
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 3 mg/m3 JAN 1993
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
BROMOCHLOROTRIFLUOROETHANE
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
BEILSTEIN REFERENCE NO. :
REFERENCE
:
LAST UPDATED
:
DATA ITEMS CITED
:
MOLECULAR FORMULA
:
MOLECULAR WEIGHT
:
WISWESSER LINE NOTATION :
COMPOUND DESCRIPTOR
:
KH6550000
Ethane, 2-bromo-2-chloro-1,1,1-trifluoro151-67-7
1736947
4-01-00-00156 (Beilstein Handbook Reference)
199907
77
C2-H-Br-Cl-F3
197.39
GYEXFFF
Tumorigen
Drug
Mutagen
Reproductive Effector
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* Bromochlorotrifluoroethane
* 1-Bromo-1-chloro-2,2,2-trifluoroethane
* 2-Bromo-2-chloro-1,1,1-trifluoroethane
* Chalothane
* Ethane, 1-bromo-1-chloro-2,2,2-trifluoro* Fluorotane
* Fluothane
* Ftorotan
* Halotan
* Halothane
* Halsan
* Narcotane
* Narcotann NE-spofa
* 1,1,1-Trifluoro-2-bromo-2-chloroethane
* 1,1,1-Trifluoro-2-chloro-2-bromoethane
* 2,2,2-Trifluoro-1-chloro-1-bromoethane
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration into the eye
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 100 mg
REACTION SEVERITY
: Severe
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for
Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
Volume(issue)/page/year: 35,729,1976
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Human
DOSE/DURATION
: 7000 ppm/3H
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), diffuse
Gastrointestinal - nausea or vomiting
Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept.,
2350
Virginia Ave., Hagerstown, MD 21740) V.11940Volume(issue)/page/year:
24,29,1963
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 129 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
Cardiac - change in rate
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.11823Volume(issue)/page/year: 1,340,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5680 mg/kg
TOXIC EFFECTS :
Behavioral - excitement
Behavioral - antipsychotic
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 24(3),36,1980
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 29000 ppm
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation,
see
PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.21939- Volume(issue)/page/year: 25,143,1962
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LC50 - Lethal concentration, 50 percent kill
Inhalation
Rodent - mouse
98 gm/m3/2H
Brain and Coverings - other degenerative changes
Liver - other changes
Kidney, Ureter, Bladder - other changes
REFERENCE :
TLSMA6 Trudy Leningradskogo Sanitarno-Gigienicheskogo Meditsinskogo
Instituta. (Leningrad, Russia) V.1-145, 1949-82. Discontinued.
Volume(issue)/page/year: 111,10,1975
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 6 gm/kg
TOXIC EFFECTS :
Behavioral - excitement
Behavioral - antipsychotic
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 24(3),36,1980
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 10000 ppm/1H/7D-I
TOXIC EFFECTS :
Liver - other changes
Nutritional and Gross Metabolic - conditioned vitamin deficiency
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd.,
Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.11981Volume(issue)/page/year: 9,9,1989
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 300 ppm/24H/5W-C
TOXIC EFFECTS :
Liver - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept.,
2350
Virginia Ave., Hagerstown, MD 21740) V.11940Volume(issue)/page/year:
42,408,1975
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2500 ppm/8H/8W-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Kidney, Ureter, Bladder - urine volume increased
Biochemical - Neurotransmitters or modulators (putative) - dopamine at
other
sites
REFERENCE :
EXNEAC Experimental Neurology. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11959- Volume(issue)/page/year: 76,168,1982
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5126 mg/m3/4H/17W-I
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 24(3),36,1980
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 500 ppm/6H/9D-I
TOXIC EFFECTS :
Gastrointestinal - other changes
Kidney, Ureter, Bladder - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other oxidoreductases
REFERENCE :
DTESD7 Developments in Toxicology and Environtal Science. (Elsevier
Science, New York, NY) V.1-15, 1977-87. Discontinued
Volume(issue)/page/year: 11,407,1983
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 300 ppm/24H/5W-C
TOXIC EFFECTS :
Liver - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept.,
2350
Virginia Ave., Hagerstown, MD 21740) V.11940Volume(issue)/page/year:
42,408,1975
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 1 pph/4H/80D-I
TOXIC EFFECTS :
Liver - other changes
Immunological Including Allergic - increase in cellular immune response
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other transferases
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1143,245,1997
1959-
Volume(issue)/page/year:
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 50 ppm/24H/5W-C
TOXIC EFFECTS :
Liver - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept.,
2350
Virginia Ave., Hagerstown, MD 21740) V.11940Volume(issue)/page/year:
42,408,1975
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 10000 ppm/1H/7D-I
TOXIC EFFECTS :
Liver - other changes
Nutritional and Gross Metabolic - conditioned vitamin deficiency
Biochemical - Effect on specific coenzyme - not otherwise specified
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd.,
Baffins
Lane, Chichester, W. Sussex PO19 1UD, UK) V.11981Volume(issue)/page/year: 9,9,1989
** REPRODUCTIVE DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TCLo - Lowest published toxic concentration
Inhalation
Rodent - rat
100 ppm/8H
female 2-22 day(s) after conception
lactating female 30 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
BBREDI Behavioural Brain Research. (Elsevier Science Publishers B.V.,
POB
211, 1000 AE Amsterdam, Netherlands) V.1- 1980- Volume(issue)/page/year:
36,147,1990
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 8000 ppm/12H
SEX/DURATION
: female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept.,
2350
Virginia Ave., Hagerstown, MD 21740)
Volume(issue)/page/year:
29,1167,1968
V.1-
1940-
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1600 ppm/8H
SEX/DURATION
: female 1-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept.,
2350
Virginia Ave., Hagerstown, MD 21740) V.11940Volume(issue)/page/year:
48,11,1978
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 10 ppm/8H
SEX/DURATION
: female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - cytological changes
(including
somatic cell genetic material)
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11967- Volume(issue)/page/year: 11,40,1976
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 8000 ppm/6H
SEX/DURATION
: female 7-9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - abortion
REFERENCE :
AAREAV Anesthesie, Analgesie, Reanimation. (Paris, France) V.14-38,
1957-81. Volume(issue)/page/year: 32,41,1975
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE
: 10 ppm/8H
SEX/DURATION
: female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - cytological changes
(including
somatic cell genetic material)
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11967- Volume(issue)/page/year: 10,174,1975
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TCLo - Lowest published toxic concentration
Inhalation
Rodent - mouse
3000 ppm/4H
female 9 week(s) pre-mating
female 1-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter;
measured
before birth)
Reproductive - Fertility - other measures of fertility
REFERENCE :
ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept.,
2350
Virginia Ave., Hagerstown, MD 21740) V.11940Volume(issue)/page/year:
48,167,1978
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TCLo - Lowest published toxic concentration
Inhalation
Rodent - mouse
1000 ppm/4H
female 9 week(s) pre-mating
female 1-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
REFERENCE :
ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept.,
2350
Virginia Ave., Hagerstown, MD 21740) V.11940Volume(issue)/page/year:
48,167,1978
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 1 pph/3H
SEX/DURATION
: female 13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 4,242,1971
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TCLo - Lowest published toxic concentration
Inhalation
Rodent - mouse
3000 ppm/4H
female 9 week(s) pre-mating
female 1-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept.,
2350
Virginia Ave., Hagerstown, MD 21740) V.11940Volume(issue)/page/year:
51,532,1979
TYPE OF TEST
: TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 14000 ppm/1H
SEX/DURATION
: female 8-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
DABBBA Dissertation Abstracts International, B: The Sciences and
Engineering. (University Microfilms International, 300 N. Zeeb Rd., Ann
Arbor, MI 48106) V.301969- Volume(issue)/page/year: 31,3599,1970
** MUTATION DATA **
TYPE OF TEST
: Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE
: Inhalation
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 1 pph/1H
REFERENCE :
ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept.,
2350
Virginia Ave., Hagerstown, MD 21740) V.11940Volume(issue)/page/year:
62,305,1985
TYPE OF TEST
: Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 3450 ppm/24H (Continuous)
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
91,225,1981
TYPE OF TEST
: Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE
: Inhalation
TEST SYSTEM
: Insect - grasshopper
DOSE/DURATION
: 46 pph/16H
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
113,467,1983
TYPE OF TEST
TEST SYSTEM
specified
DOSE/DURATION
REFERENCE :
: Mutation test systems - not otherwise specified
: Non-mammalian species Cells - not otherwise
: 1 mmol/L
ECREAL Experimental Cell Research.
(Academic Press, Inc., 1 E. First
St.,
Duluth, MN 55802) V.10-
1950-
Volume(issue)/page/year: 141,492,1982
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 1 pph/48H (Continuous)
REFERENCE :
NSMZDZ Nippon Shika Masui Gakkai Zasshi. Journal of Japanese Dental
Anesthesia Society. (Nippon Shika Masui Gakkai, c/o Koko Hoken Kyokai,
1-44-2, Komagome, Toshima-ku, Tokyo 170, Japan) V.11973Volume(issue)/page/year: 7,19,1979
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 4 mmol/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
413,1,1998
TYPE OF TEST
: Unscheduled DNA synthesis
ROUTE OF EXPOSURE
: Inhalation
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 1000 ppm/2H (Continuous)
REFERENCE :
ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept.,
2350
Virginia Ave., Hagerstown, MD 21740) V.11940Volume(issue)/page/year:
30,401,1969
TYPE OF TEST
: Unscheduled DNA synthesis
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 10 gm/kg
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 10,327,1982
TYPE OF TEST
: Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE
: Inhalation
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 1 pph/1H
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11958Volume(issue)/page/year:
27,2187,1978
TYPE OF TEST
: DNA inhibition
ROUTE OF EXPOSURE
: Inhalation
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 8000 ppm/24H (Continuous)
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.11941- Volume(issue)/page/year:
36,3156,1976
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - mouse Fibroblast
DOSE/DURATION
: 1000 ppm
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11967- Volume(issue)/page/year: 12,366,1976
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Rodent - hamster Fibroblast
DOSE/DURATION
: 1 pph
REFERENCE :
ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept.,
2350
Virginia Ave., Hagerstown, MD 21740) V.11940Volume(issue)/page/year:
43,21,1975
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Lung
DOSE/DURATION
: 1 pph/48H (Continuous)
REFERENCE :
NSMZDZ Nippon Shika Masui Gakkai Zasshi. Journal of Japanese Dental
Anesthesia Society. (Nippon Shika Masui Gakkai, c/o Koko Hoken Kyokai,
1-44-2, Komagome, Toshima-ku, Tokyo 170, Japan) V.11973Volume(issue)/page/year: 7,19,1979
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Parenteral
TEST SYSTEM
: Bird - chicken
DOSE/DURATION
: 10 mg
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11967- Volume(issue)/page/year: 12,366,1976
*** REVIEWS ***
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 404 mg/m3 (50 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Inadequate Evidence
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,93,1987
TOXICOLOGY REVIEW
ARPTDI Annual Review of Pharmacology and Toxicology.
Inc.,
(Annual Reviews,
POB 10139, Palo Alto, CA 94303)
16,67,1976
V.16-
1976- Volume(issue)/page/year:
TOXICOLOGY REVIEW
INTEAG Internist. (Springer-Verlag New York, Inc., Service Center, 44
Hartz
Way, Secaucus, NJ 07094) V.11960- Volume(issue)/page/year:
15,7,1974
TOXICOLOGY REVIEW
ARMCAH Annual Review of Medicine. (Annual Reviews, Inc., POB 10139, Palo
Alto, CA 94303) V.11950- Volume(issue)/page/year: 25,411,1974
TOXICOLOGY REVIEW
CJSUAX Canadian Journal of Surgery. (Canadian Medical Assoc., POB 8650,
Ottawa, ON K1G 0G8, Canada) V.11957- Volume(issue)/page/year:
15,217,1972
TOXICOLOGY REVIEW
AASXAP Acta Anaesthesiologica Scandinavica, Supplementum. (Munksgaard
International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) No.1- 1959Volume(issue)/page/year: 49,1,1971
TOXICOLOGY REVIEW
AACRAT Anesthesia and Analgesia (New York). (Elsevier Science Pub. Co.,
Inc., 52 Vanderbilt Ave., New York, NY 10017) V.361957Volume(issue)/page/year: 57,328,1978
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 0.5 ppm (4.1 mg/m3) JAN 1993
OEL-AUSTRIA: MAK 5 ppm (40 mg/m3), JAN1999
OEL-AUSTRIA:TWA 5 ppm (40 mg/m3) JAN 1993
OEL-BELGIUM:TWA 50 ppm (404 mg/m3) JAN 1993
OEL-DENMARK: TWA 5 ppm (40 mg/m3), JAN1999
OEL-FINLAND:TWA 1 ppm (8 mg/m3);STEL 3 ppm (24 mg/m3) JAN 1993
OEL-GERMANY:TWA 5 ppm (40 mg/m3) JAN 1993
OEL-HUNGARY:TWA 30 mg/m3;STEL 60 mg/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 5 ppm (40 mg/m3) JAN 1993
OEL-RUSSIA:STEL 20 mg/m3 JAN 1993
OEL-POLAND: TWA 40 mg/m3, STEL 100 mg/m3, JAN1999
OEL-SWEDEN:TWA 5 ppm (40 mg/m3);STEL 10 ppm (80 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 5 ppm (40 mg/m3);STEL 10 ppm (80 mg/m3) JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO HALOTHANE-air:CL 2 ppm/60M
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 82943
No. of Facilities: 806 (estimated)
No. of Industries: 2
No. of Occupations: 8
No. of Employees: 9490 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 82943
No. of Facilities: 4118 (estimated)
No. of Industries: 3
No. of Occupations: 15
No. of Employees: 94682 (estimated)
No. of Female Employees: 76108 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion; S
cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-reversion
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse; V79 cell
culture-gene mutation
EPA GENETOX PROGRAM 1988, Negative/limited: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
OSHA ANALYTICAL METHOD #29
BROMOCINNAMALDEHYDE (ALPHA-)
RTECS NUMBER
: GD6480000
CHEMICAL NAME
: Cinnamaldehyde, alpha-bromoCAS REGISTRY NUMBER
: 5443-49-2
BEILSTEIN REFERENCE NO. : 1099733
REFERENCE
: 2-07-00-00281 (Beilstein Handbook Reference)
LAST UPDATED
: 199612
DATA ITEMS CITED
: 2
MOLECULAR FORMULA
: C9-H7-Br-O
MOLECULAR WEIGHT
: 211.07
WISWESSER LINE NOTATION : VHYEU1R
COMPOUND DESCRIPTOR
: Mutagen
SYNONYMS/TRADE NAMES :
* Alphabrocine
* B 36
* B 37
* alpha-Bromocinnamaldehyde
* 2-Bromocinnamaldehyde
* alpha-Bromocinnamic aldehyde
* 2-Bromo-3-phenyl-2-propenal
* 2-Propenal, 2-bromo-3-phenyl*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 470 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis
Behavioral - ataxia
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
SRTCAC Science Reports of the Research Institutes, Tohoku University,
Series
C: Medicine. (Tohoku University, Research Institute for Tuberculosis and
Cancer, 4-1 Seiryo-machi, Sendai, Japan) V.11949Volume(issue)/page/year: 36(1-4),10,1989
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 5 nmol/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
110,1,1983
BROMODECANE (1-)
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
SYNONYMS/TRADE NAMES :
* 1-Bromodecane
:
:
:
:
:
:
:
:
HD6850000
Decane, 1-bromo112-29-8
199701
4
C10-H21-Br
221.22
E10
* Decyl bromide
* n-Decyl bromide
* 1-Decyl bromide
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 4070 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 20(12),52,1976
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Mammal - species unspecified
DOSE/DURATION
: 4200 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 18(4),55,1974
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4040
No. of Facilities: 17 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 187 (estimated)
No. of Female Employees: 34 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
BROMODEOXYURIDINE (5,2'-)
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
BEILSTEIN REFERENCE NO. :
REFERENCE
:
LAST UPDATED
:
DATA ITEMS CITED
:
YU7350000
Uridine, 5-bromo-2'-deoxy59-14-3
0030395
4-24-00-01234 (Beilstein Handbook Reference)
199712
151
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
C9-H11-Br-N2-O5
307.13
T6NVMVJ EE A- ET5OTJ B1Q CQ
Tumorigen
Drug
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* BDU
* 5-Bdu
* Bromodeoxyuridine
* 5-Bromodeoxyuridine
* 5-Bromodesoxyuridine
* 5-Bromo-2-deoxyuridine
* 5-Bromo-2'-deoxyuridine
* Bromouracil deoxyriboside
* 5-Bromouracil deoxyriboside
* 5-Bromouracil-2-deoxyriboside
* Broxuridine
* Brudr
* BUDR
* 5-Budr
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 8400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.11970Volume(issue)/page/year: 4,467,1973
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ADTEAS Advances in Teratology. (New York, NY) V.1-5, 1966-72.
Discontinued. Volume(issue)/page/year: 3,181,1968
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3900 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Cardiac - pulse rate
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories.
(Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka
532,
Japan)
V.29-
1970-
Volume(issue)/page/year: 30,530,1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2320 mg/kg
TOXIC EFFECTS :
Vascular - other changes
REFERENCE :
TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories.
(Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka
532,
Japan) V.291970- Volume(issue)/page/year: 30,735,1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 2300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,721,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 9100 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
Blood - changes in spleen
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories.
(Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka
532,
Japan) V.291970- Volume(issue)/page/year: 30,530,1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 3050 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Cardiac - pulse rate
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories.
(Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka
532,
Japan) V.291970- Volume(issue)/page/year: 30,530,1971
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Subcutaneous
Rodent - mouse
3500 mg/kg
Behavioral - somnolence (general depressed activity)
Cardiac - pulse rate
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories.
(Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka
532,
Japan) V.291970- Volume(issue)/page/year: 30,530,1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 2500 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Cardiac - pulse rate
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories.
(Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka
532,
Japan) V.291970- Volume(issue)/page/year: 30,530,1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - quail
DOSE/DURATION
: >100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1
E.
First St., Duluth, MN 55802) V.11977- Volume(issue)/page/year:
6,149,1982
** TUMORIGENIC DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 16 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Endocrine - thyroid tumors
Reproductive - Tumorigenic effects - testicular tumors
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
295,113,1993
** REPRODUCTIVE DATA **
TYPE OF TEST
:
ROUTE OF EXPOSURE
:
SPECIES OBSERVED
:
DOSE
:
SEX/DURATION
:
TOXIC EFFECTS :
Reproductive - Effects
TDLo - Lowest published toxic dose
Intraperitoneal
Rodent - rat
250 mg/kg
female 13 day(s) after conception
on Embryo or Fetus - cytological changes
(including
somatic cell genetic material)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 23,383,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 200 mg/kg
SEX/DURATION
: female 13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories.
(Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka
532,
Japan) V.291970- Volume(issue)/page/year: 30,636,1971
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 500 mg/kg
SEX/DURATION
: female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - respiratory system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 44,165,1991
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 700 mg/kg
SEX/DURATION
: female 9-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
alive at weaning per # alive at day 4)
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
REFERENCE :
TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories.
(Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka
532,
Japan) V.291970- Volume(issue)/page/year: 30,636,1971
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: TDLo - Lowest published toxic dose
: Intraperitoneal
: Rodent - mouse
DOSE
: 600 mg/kg
SEX/DURATION
: female 8-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - delayed effects
REFERENCE :
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11987Volume(issue)/page/year:
11,663,1997
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 400 mg/kg
SEX/DURATION
: female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss,
Inc.,
41 E. 11th St., New York, NY 10003) V.11980Volume(issue)/page/year:
7,7,1987
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 300 mg/kg
SEX/DURATION
: female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 4,87,1971
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 200 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
Reproductive - Specific Developmental Abnormalities - eye/ear
REFERENCE :
TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories.
(Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka
532,
Japan) V.291970- Volume(issue)/page/year: 30,636,1971
TYPE OF TEST
ROUTE OF EXPOSURE
: TDLo - Lowest published toxic dose
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 200 mg/kg
SEX/DURATION
: female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories.
(Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka
532,
Japan) V.291970- Volume(issue)/page/year: 30,636,1971
TYPE OF TEST
:
ROUTE OF EXPOSURE
:
SPECIES OBSERVED
:
DOSE
:
SEX/DURATION
:
TOXIC EFFECTS :
Reproductive - Effects
TDLo - Lowest published toxic dose
Intraperitoneal
Rodent - mouse
400 mg/kg
female 8 day(s) after conception
on Newborn - viability index (e.g., # alive at day
4
per # born alive)
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis.
Inc.,
41 E. 11th St., New York, NY 10003) V.11980Volume(issue)/page/year:
4,403,1984
(Alan R. Liss,
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 40 mg/kg
SEX/DURATION
: female 6 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - other effects to embryo
REFERENCE :
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
Switzerland) V.11945- Volume(issue)/page/year: 33,448,1977
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 300 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 32,229,1985
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
:
:
:
:
TDLo - Lowest published toxic dose
Parenteral
Rodent - mouse
1200 mg/kg
SEX/DURATION
: female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - cytological changes
(including
somatic cell genetic material)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 26,195,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 600 mg/kg
SEX/DURATION
: female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - eye/ear
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 26,195,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 1 gm/kg
SEX/DURATION
: female 7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 4,242,1971
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Parenteral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 1 gm/kg
SEX/DURATION
: female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 4,242,1971
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: TDLo - Lowest published toxic dose
: Unreported
: Rodent - mouse
DOSE
: 500 mg/kg
SEX/DURATION
: female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development.
(Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.11968Volume(issue)/page/year: 34,412,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 400 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
JEEMAF Journal of Embryology and Experimental Morphology. (Essex, UK)
V.1-98, 1953-86. For Publisher information, see DEVPED
Volume(issue)/page/year: 43,47,1978
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 400 mg/kg
SEX/DURATION
: female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
JEEMAF Journal of Embryology and Experimental Morphology. (Essex, UK)
V.1-98, 1953-86. For Publisher information, see DEVPED
Volume(issue)/page/year: 43,47,1978
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 640 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
JEEMAF Journal of Embryology and Experimental Morphology. (Essex, UK)
V.1-98, 1953-86. For Publisher information, see DEVPED
Volume(issue)/page/year: 43,47,1978
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Intraperitoneal
Rodent - hamster
900 mg/kg
female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - cytological changes
(including
somatic cell genetic material)
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
AJANA2 American Journal of Anatomy. (Alan R. Liss, Inc., 41 E. 11th St.,
New York, NY 10003) V.1-192, 1901-91. Volume(issue)/page/year:
190,219,1991
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 400 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview
Park,
Elmsford, NY 10523) V.1-8, 1962-69; V.141974Volume(issue)/page/year:
4,633,1965
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 400 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
Reproductive - Specific Developmental Abnormalities - eye/ear
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview
Park,
Elmsford, NY 10523) V.1-8, 1962-69; V.141974Volume(issue)/page/year:
4,633,1965
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - hamster
DOSE
: 400 mg/kg
SEX/DURATION
: female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
ANREAK Anatomical Record. (Alan R. Liss, Inc., 41 E. 11th St., New York,
NY
10003) V.11906/08- Volume(issue)/page/year: 151,473,1965
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 10 mg/L
REFERENCE :
GENTAE Genetics. (Genetics Business Office, POB 64025, Baltimore, MD
21264)
V.11916- Volume(issue)/page/year: 51,545,1965
TYPE OF TEST
: DNA repair
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 30 mg/L
REFERENCE :
MGGEAE Molecular and General Genetics. (Springer-Verlag, Heidelberger
Pl.
3, D-1000 Berlin 33, Fed. Rep. Ger.) V.991967Volume(issue)/page/year: 171,135,1979
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 30 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
108,13,1983
TYPE OF TEST
: Phage inhibition capacity
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 1 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
178,177,1987
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 100 mg/L
REFERENCE :
MGGEAE Molecular and General Genetics. (Springer-Verlag, Heidelberger
Pl.
3, D-1000 Berlin 33, Fed. Rep. Ger.) V.991967Volume(issue)/page/year: 128,359,1974
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 1600 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
23,267,1974
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 1200 mg/L
REFERENCE :
ZAPOAK Zeitschrift fuer Allgemeine Mikrobiologie. (Akademie-Verlag GmbH,
Postfach 1233, Berlin DDR-1086 Ger. Dem. Rep.) V.11960Volume(issue)/page/year: 16,279,1976
TYPE OF TEST
TEST SYSTEM
: Mutation in microorganisms
: Microorganism - not otherwise specified
DOSE/DURATION
: 50 mg/L
REFERENCE :
SOGEBZ Soviet Genetics. English translation of GNKAA5.
Corp.,
233 Spring St., New York, NY 10013) V.21966Volume(issue)/page/year:
6,1623,1970
(Plenum Pub.
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 16 umol/L
REFERENCE :
AVIRA2 Acta Virologica (English Edition). (Academic Press Inc. Ltd.,
24-28
Oval Rd., London NW1 7DX, UK) V.11957- Volume(issue)/page/year:
21,397,1977
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 7500 ng/L
REFERENCE :
JNCSAI Journal of Cell Science. (Biochemical Soc. Book Depot, POB 32,
Commerce Way, Colchester, Essex CO2 8HP, UK) V.11966Volume(issue)/page/year: 17,495,1975
TYPE OF TEST
: Unscheduled DNA synthesis
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 1 mmol/L
REFERENCE :
EJBCAI European Journal of Biochemistry. (Springer-Verlag New York,
Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.11967Volume(issue)/page/year: 62,345,1976
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Microorganism - not otherwise specified
DOSE/DURATION
: 7500 ng/L
REFERENCE :
JNCSAI Journal of Cell Science. (Biochemical Soc. Book Depot, POB 32,
Commerce Way, Colchester, Essex CO2 8HP, UK) V.11966Volume(issue)/page/year: 17,495,1975
TYPE OF TEST
: Specific locus test
ROUTE OF EXPOSURE
: Parenteral
TEST SYSTEM
: Insect - Drosophila melanogaster
DOSE/DURATION
: 16 mmol/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11958Volume(issue)/page/year:
15,299,1966
TYPE OF TEST
ROUTE OF EXPOSURE
TEST SYSTEM
DOSE/DURATION
REFERENCE :
GENTAE Genetics.
21264)
:
:
:
:
Sister chromatid exchange
Oral
Insect - Drosophila melanogaster
25 mg/L
(Genetics Business Office, POB 64025, Baltimore, MD
V.1-
1916-
TYPE OF TEST
TEST SYSTEM
Volume(issue)/page/year: 100,259,1982
: Sister chromatid exchange
: Insect - Drosophila melanogaster Cells - not
otherwise specified
: 250 ug/L
DOSE/DURATION
REFERENCE :
GENTAE Genetics. (Genetics Business Office, POB 64025, Baltimore, MD
21264)
V.11916- Volume(issue)/page/year: 100,259,1982
TYPE OF TEST
TEST SYSTEM
: Sister chromatid exchange
: Insect - Drosophila melanogaster Cells - not
otherwise specified
: 10 mg/L
DOSE/DURATION
REFERENCE :
CHROAU Chromosoma. (Springer-Verlag New York, Inc., Service Center, 44
Hartz Way, Secaucus, NJ 07094) V.11939- Volume(issue)/page/year:
69,339,1978
TYPE OF TEST
: Cytogenetic analysis
ROUTE OF EXPOSURE
: Oral
TEST SYSTEM
: Insect - grasshopper
DOSE/DURATION
: 48 gm/kg
REFERENCE :
NULSAK Nucleus (Calcutta). (Dr. A.K. Sharma, Centre of Advanced Studies
in
Cell and Chromosome Research, Calcutta, 35 Baliygunge Circular Rd.,
Calcutta
700 019, India) V.11958- Volume(issue)/page/year: 11,50,1968
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Non-mammalian species Embryo
DOSE/DURATION
: 50 mg/L
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ
08736)
V.11869- Volume(issue)/page/year: 249,350,1974
TYPE OF TEST
TEST SYSTEM
: Sister chromatid exchange
: Insect - not otherwise specified Cells - not
otherwise specified
: 40 umol/L
DOSE/DURATION
REFERENCE :
CYTBAI Cytobios. (Faculty Press, 88 Regent St., Cambridge, UK)
1969Volume(issue)/page/year: 46,181,1986
V.1-
TYPE OF TEST
: Sister chromatid exchange
ROUTE OF EXPOSURE
: Administration onto the skin
TEST SYSTEM
: Non-mammalian species
DOSE/DURATION
: 20 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
105,235,1982
TYPE OF TEST
ROUTE OF EXPOSURE
: Sister chromatid exchange
: Intraperitoneal
TEST SYSTEM
: Fish - not otherwise specified
DOSE/DURATION
: 500 mg/kg
REFERENCE :
CHROAU Chromosoma. (Springer-Verlag New York, Inc., Service Center, 44
Hartz Way, Secaucus, NJ 07094) V.11939- Volume(issue)/page/year:
56,101,1976
TYPE OF TEST
: Sister chromatid exchange
ROUTE OF EXPOSURE
: Intramuscular
TEST SYSTEM
: Fish - not otherwise specified
DOSE/DURATION
: 500 mg/kg
REFERENCE :
NULSAK Nucleus (Calcutta). (Dr. A.K. Sharma, Centre of Advanced Studies
in
Cell and Chromosome Research, Calcutta, 35 Baliygunge Circular Rd.,
Calcutta
700 019, India) V.11958- Volume(issue)/page/year: 25,161,1982
TYPE OF TEST
: Micronucleus test
TEST SYSTEM
: Human Fibroblast
DOSE/DURATION
: 82 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
4,353,1967
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Human Fibroblast
DOSE/DURATION
: 10 umol/L
REFERENCE :
BLFSBY Basic Life Sciences. (Plenum Pub. Corp., 223 Spring St., New
York,
NY 10003) V.11973- Volume(issue)/page/year: 29A,69,1984
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human HeLa cell
DOSE/DURATION
: 1 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
93,447,1982
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human Fibroblast
DOSE/DURATION
: 82 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
4,353,1967
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human Leukocyte
DOSE/DURATION
: 200 mg/L
REFERENCE :
ECREAL Experimental Cell Research. (Academic Press, Inc., 1 E. First
St.,
Duluth, MN 55802) V.101950- Volume(issue)/page/year: 34,182,1964
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 13 mg/L
REFERENCE :
CYTOAN Cytologia. (Japan Pub. Trading Co. (USA), 1255 Howard St., San
Francisco, CA 94103) V.11929- Volume(issue)/page/year: 46,387,1981
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 15 mg/L
REFERENCE :
CHROAU Chromosoma. (Springer-Verlag New York, Inc., Service Center, 44
Hartz Way, Secaucus, NJ 07094) V.11939- Volume(issue)/page/year:
93,87,1985
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 20 umol/L
REFERENCE :
HEREAY Hereditas (Lund, Sweden). (Gjoerloffsgatan 121, S-261 34
Landskrona,
Sweden) V.11947- Volume(issue)/page/year: 83,163,1976
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Human Leukocyte
DOSE/DURATION
: 10 mg/L
REFERENCE :
AGTQAH Annales de Genetique. (Expansion Scientifique Francaise, 15 rue
Saint-Benoit, F-75278, Paris Cedex 06, France) V.11958Volume(issue)/page/year: 19,225,1976
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Human Fibroblast
DOSE/DURATION
: 10 mg/L
REFERENCE :
CYTBAI Cytobios. (Faculty Press, 88 Regent St., Cambridge, UK)
1969Volume(issue)/page/year: 38,159,1983
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Human Ovary
DOSE/DURATION
: 20 mg/L
REFERENCE :
CYTBAI Cytobios. (Faculty Press, 88 Regent St., Cambridge, UK)
1969Volume(issue)/page/year: 38,159,1983
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Human Cells - not otherwise specified
DOSE/DURATION
: 15 mg/L
REFERENCE :
CYTBAI Cytobios. (Faculty Press, 88 Regent St., Cambridge, UK)
1969Volume(issue)/page/year: 38,159,1983
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Human Testis
DOSE/DURATION
: 15 mg/L
REFERENCE :
CYTBAI Cytobios. (Faculty Press, 88 Regent St., Cambridge, UK)
V.1-
V.1-
V.1-
V.1-
1969Volume(issue)/page/year: 38,159,1983
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Human Fibroblast
DOSE/DURATION
: 15 mg/L
REFERENCE :
CSHSAZ Cold Spring Harbor Symposia on Quantitative Biology. (Cold Spring
Harbor Laboratory, POB 100, Cold Spring Harbor, NY 11724) V.11933Volume(issue)/page/year: 29,151,1965
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 100 umol/L
REFERENCE :
LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview
Park,
Elmsford, NY 10523) V.1-8, 1962-69; V.141974Volume(issue)/page/year:
19,563,1976
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Human Cells - not otherwise specified
DOSE/DURATION
: 10 umol/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
14,107,1989
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Human Ovary
DOSE/DURATION
: 10 umol/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
14,107,1989
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - rat Embryo
DOSE/DURATION
: 100 umol/L
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United
States
of America. (National Academy of Sciences, Printing & Pub. Office, 2101
Constitution Ave., Washington, DC 20418) V.11915Volume(issue)/page/year: 71,3570,1974
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - rat Cells - not otherwise specified
DOSE/DURATION
: 1 umol/L
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ
08736)
V.11869- Volume(issue)/page/year: 256,438,1975
TYPE OF TEST
ROUTE OF EXPOSURE
: DNA inhibition
: Subcutaneous
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 1087 mg/kg
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 5,695,1983
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Rodent - rat Lymphocyte
DOSE/DURATION
: 1 umol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 4,585,1982
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - rat Lymphocyte
DOSE/DURATION
: 25 umol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 4,585,1982
TYPE OF TEST
: Sister chromatid exchange
ROUTE OF EXPOSURE
: Intravenous
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 80 mg/kg/24H (Continuous)
REFERENCE :
ECREAL Experimental Cell Research. (Academic Press, Inc., 1 E. First
St.,
Duluth, MN 55802) V.101950- Volume(issue)/page/year: 102,426,1976
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - rat Lymphocyte
DOSE/DURATION
: 1 umol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 4,585,1982
TYPE OF TEST
: Mutation in mammalian somatic cells
ROUTE OF EXPOSURE
: Subcutaneous
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 1087 mg/kg
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 5,695,1983
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - rat Cells - not otherwise specified
DOSE/DURATION
: 5 mg/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 5,695,1983
TYPE OF TEST
: Sperm Morphology
ROUTE OF EXPOSURE
: Subcutaneous
TEST SYSTEM
: Rodent - rat
DOSE/DURATION
: 150 mg/kg
REFERENCE :
JEZOAO Journal of Experimental Zoology. (Alan R. Liss, Inc., 41 E. 11th
St., New York, NY 10003) V.11904- Volume(issue)/page/year:
200,1,1977
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 500 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
301,45,1993
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - mouse Lymphocyte
DOSE/DURATION
: 10 umol/L
REFERENCE :
BLFSBY Basic Life Sciences. (Plenum Pub. Corp., 223 Spring St., New
York,
NY 10003) V.11973- Volume(issue)/page/year: 29A,69,1984
TYPE OF TEST
: DNA damage
TEST SYSTEM
: Rodent - mouse Fibroblast
DOSE/DURATION
: 72 umol/L
REFERENCE :
BBRCA9 Biochemical and Biophysical Research Communications. (Academic
Press, Inc., 1 E. First St., Duluth, MN 55802) V.11959Volume(issue)/page/year: 59,920,1974
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent