Dr Lucy Chappell’s publications
1. Bramham K, Parnell B, Nelson-Piercy C, Seed PT, Poston L, Chappell LC. Chronic hypertension and
pregnancy outcomes: systematic review and meta-analysis. BMJ 2014; 348:g2301. doi:
10.1136/bmj.g2301.
2. Hall M, Chappell LC, Parnell BL, Seed PT, Bewley S. Associations between Intimate Partner Violence
and Termination of Pregnancy: A Systematic Review and Meta-Analysis. PLoS Med 2014; 11:
e1001581. doi:10.1371/journal.pmed.1001581.
3. Geenes V, Chappell LC, Seed PT, Steer P, Knight M, Williamson C. Severe intrahepatic cholestasis of
pregnancy and adverse pregnancy outcomes: a prospective population-based case-control study.
Hepatology 2014; 59:1482-91. doi: 10.1002/hep.26617.
4. Geenes V, Lövgren-Sandblom A, Benthin L, Lawrance D, Chambers J, Gurung V, Thornton J, Chappell L,
Khan E, Dixon P, Marschall H-U, Williamson C. The Reversed Feto-Maternal Bile Acid Gradient in
Intrahepatic Cholestasis of Pregnancy is Corrected by Ursodeoxycholic Acid. PLoS One 2014; 9:
e83828. doi: 10.1371/journal.pone.0083828.
5. Chappell, LC, Duckworth S, Seed PT, Griffin M, Myers J, Mackillop L, Simpson N, Waugh J, Anumba D,
Kenny L, Redman C, Shennan AT. Diagnostic accuracy of Placental Growth Factor in women with
suspected preeclampsia: a prospective multicentre study. Circulation 2013; 128:2121-31. doi:
10.1161/CIRCULATIONAHA.113.003215.
6. Chappell LC, Seed PT, Myers J, Taylor R, Kenny L, Dekker G, Walker H, McCowan L, North R, Poston L.
Factors associated with uncomplicated pregnancy in nulliparous women: exploration and
confirmation
in
a
prospective
cohort
study.
BMJ
2013; 347 doi:
http://dx.doi.org/10.1136/bmj.f6398.
7. Bramham K, Poli-de-Figueiredo C, Seed, PT, Briley AL, Poston L, Shennan AH, Chappell LC. Association
of proteinuria threshold in pre-eclampsia with maternal and perinatal outcomes: a nested case
control cohort of high risk women. PLoS One 2013; 8:e76083. doi: 10.1371/journal.pone.0076083.
8. Cutler J, Chappell LC, Kyle P, Madan B. Third trimester amniocentesis for diagnosis of inherited
bleeding disorders prior to delivery. Haemophilia 2013; 19:904-7. doi: 10.1111/hae.12247.
9. Mistry HD, Bramham K, Weston AJ, Ward MA, Thompson AJ, Chappell LC. Urine protein
concentration estimation for biomarker discovery. Preg Hypertension 2013; 3:211-4.
doi:10.1016/j.preghy.2013.07.
10. Chappell LC, Gurung V, Seed PT, Chambers J, Williamson C, Thornton JG. Ursodeoxycholic acid versus
placebo, and early term delivery versus expectant management, in women with intrahepatic
cholestasis of pregnancy: semifactorial randomised clinical trial. BMJ 2012; 344:e3799.
11. Poston L, Igosheva N, Mistry HD, Seed PT, Shennan AH, Rana S, Karumanchi SA, Chappell LC. Role of
oxidative stress and antioxidant supplementation in pregnancy disorders. Am J Clin Nutr. 2011. 94: 6
Suppl 1980S-1985S.
12. Chandiramani M, Chappell L, Radford S, Shennan A. Successful pregnancy following mid-trimester
evacuation through a transabdominal cervical cerclage. BMJ Case Rep. 2011. pii: bcr0220113841..
doi: 10.1136/bcr.02.2011.3841.
13. Carty DM, Siwy J, Brennand J, Zürbig P, Mullen W, Franke J, McCulloch JW, North R, Chappell LC,
Mischak H, Poston L, Dominiczak A, Delles C. Urinary proteomics for prediction of pre-eclampsia.
Hypertension 2011 57(3):561-9.
14. Bramham K, Briley A, Seed PT, Poston L, Shennan AH, Chappell LC. Adverse Maternal and Perinatal
Outcomes in Women with Previous Preeclampsia: A Prospective Study. AJOG 2011; 204:512.e1-9.
15. Bramham K, Briley A, Seed PT, Poston L, Shennan AH, Chappell LC. Pregnancy Outcome in Women
with Chronic Kidney Disease: a prospective cohort study. Reprod Sci 2011; 18:623-30.
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16.
Webster J, Chappell L, Cheng F, Breeze A, Lucas N, Plaat F, Williamson C. Operative delivery rates
are not increased following induction of labour in women with obstetric cholestasis. Obstetric
Medicine 2011; 4: 66–69. doi: 10.1258/om.2011.100080.
17. Seed P, Chappell LC, Black MA, Poppe KK, Hwang Y-C, Kasabov N, McCowan L, Shennan A, Wu, SH,
Poston L, North R. Prediction of preeclampsia and delivery of small for gestational age babies based
on a combination of clinical risk factors in high-risk women. Hypertens Pregnancy 2011; 30:58-73.
18. McCowan LME, Roberts CT, Dekker GA, Taylor RS, Chan EHY, Kenny LC, Baker PN, Moss-Morris R,
Chappell LC, North R. Risk factors for infants small for gestational age by customised birthweight
centiles: data from an international prospective cohort study. BJOG 2010; 117(13):1599-607.
19. Chappell LC, Seed P, Enye S, Briley AL, Poston L, Shennan AH. Clinical and geographic variation in
prophylactic and therapeutic treatments for pre-eclampsia in the UK. BJOG 2010; 117(6):695-700.
20. Chappell LC. A critical analysis and appraisal of two papers from the educational literature: a story of
turning a petroleum engineer into an explorer? Higher Education Research Network Journal 2010;
1:69-74.
21. McCowan LM, Dekker GA, Chan E, Stewart A, Chappell LC, Hunter M, Moss-Morris R, North RA; SCOPE
consortium. Spontaneous preterm birth and small for gestational age infants in women who stop
smoking early in pregnancy: prospective cohort study. BMJ 2009; 338:b1081.
22. Chappell LC, Enye S, Seed P, Briley AL, Poston L, Shennan AH. Adverse Perinatal Outcomes and Risk
Factors for Pre-eclampsia in Women with Chronic Hypertension. A Prospective study. Hypertension
2008;51:1002-9.
23. Barigye O, Pasquini L, Chappell L, Vanderheyden T, Wimalasundera R, Fisk N. Interstitial laser for
fetal reduction in complicated monochorionic multiple pregnancy. Prenatal Diagnosis 2008; 28:53543.
24. Pasquini L, Wimalasundera R, Fichera A, Barigye O, Chappell L, Fisk NM. High perinatal survival in
monoamniotic twins managed by prophylactic sulindac, intensive ultrasound surveillance, and
caesarean delivery at 32 weeks. Ultrasound Obstet Gynecol 2006; 28:681-7.
25. Barigye O, Pasquini L, Galea P, Chambers H, Chappell L, Fisk NM. High risk of unexpected late fetal
death in monochorionic twins despite intensive ultrasound surveillance: a cohort study. PloS Med
2005; 2(6):e172.
26. Goulis D, Chappell LC, Gibbs RG, Williams D, Dave JR, Taylor P, de Swiet M, Poston L, Williamson C.
Association of raised titres of antibodies to Chlamydia pneumoniae with a history of pre-eclampsia.
BJOG 2005;112:299-305.
27. Chappell LC, Seed PT, Kelly FJ Briley A, Hunt BJ, Charnock-Jones DS, Mallet A, Poston L. Vitamin C and E
supplementation in women at risk of pre-eclampsia is associated with changes in indices of
oxidative stress and placental function. Am J Obstet Gynecol 2002;187:777-784.
28. Chappell LC, Seed PT, Briley A, Kelly FJ, Hunt BJ, Charnock-Jones DS, Mallet AI, Poston L. A longitudinal
study of biochemical variables in women at risk of pre-eclampsia. Am J Obs Gynecol 2002;187:127-36.
29. Chappell LC, Seed PT, Briley AL, Kelly FJ, Lee R, Hunt BJ, Parmar K, Bewley SJ, Shennan AH, Steer PJ,
Poston L. Effect of antioxidants on the occurrence of pre-eclampsia in women at increased risk: a
randomised trial. Lancet 1999;354:810-6.
30. Chappell L, Poulton L, Halligan A, Shennan AH. Lack of consistency in research papers over the
definition of pre-eclampsia. BJOG 1999;106:983-5.
Reviews
31. Walker I, Chappell LC, Williamson C. Rational testing: Abnormal liver function tests in pregnancy.
BMJ 2013; 347:f6055. doi: 10.1136/bmj.f6055.
32. Bramham K, Nelson-Piercy C, Brown MJ, Chappell LC. Postpartum management of hypertension. BMJ.
2013;346:f894. doi: 10.1136/bmj.f894.
33. Seshadri S, Oakeshott P, Nelson-Piercy C, Chappell LC. Prepregnancy care. BMJ 2012;344:e3467.
34. Duckworth S, Mistry H, Chappell LC. Vitamin supplementation in pregnancy. The Obstetrician and
Gynaecologist 2012;14:175–178.
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35. Griffin M, Chappell LC. Prediction of Pre-eclampsia – Screening, Biomarkers and Perspectives for the
Future. European Obstetrics and Gynaecology 2012;7:18–24
36. Hezelgrave NL, Whitty CJ, Shennan AH, Chappell LC. Advising on travel during pregnancy. BMJ. 2011;
342:d2506.
37. Poston L, Chappell LC, Seed PT, Shennan AH. Biomarkers of oxidative stress in pre-eclampsia.
Pregnancy Hypertension 2011 1; 22-27.
38. Obstetric anal sphincter injury. Abbott D, Atere-Roberts N, Williams A, Oteng-Ntim E. Chappell LC.
BMJ 2010; 341:c3414.
39. Bramham K, Mistry HD, Poston L, Chappell LC, Thompson A. The Non-Invasive Biopsy - Will Urinary
Proteomics make the Renal Tissue Biopsy Redundant? QJM 2009; 102(8):523-38.
40. Chappell LC. Recent advances in pre-eclampsia and eclampsia. Tropical Doctor 2004; 34:1.
41. Poston L, Chappell LC. Is oxidative stress involved in the aetiology of pre-eclampsia? Acta Paediatr
Suppl 2001; 90:3-5.
42. Shennan AH, Chappell L. Pre-eclampsia. Contemp Clin Gynecol Obstet. 2001; 1:353-64.
43. Briley A, Chappell L, Kelly F, Shennan A, Poston L. The Vitamins in Pre-eclampsia Study. RCM
Midwives Journal 2001; 4:288-91.
44. Chappell L, Shennan A. The role of uterine artery Doppler in obstetrics. CML Gynaecology and
Obstetrics 1999; 5:57-61.
45. Chappell L, Bewley S. Pre-eclamptic toxaemia: the role of uterine artery Doppler. BJOG 1998;
105:379-82.
Editorials
46. Chappell LC, Williamson C. Liver: Links between hepatobiliary diseases in and beyond pregnancy. Nat
Rev Gastroenterol Hepatol. 2013 10(7):387-8. doi: 10.1038/nrgastro.2013.92.
47. Chappell LC, Calderwood C, Kenyon S, Draper ES, Knight M. Understanding patterns in maternity care
in the NHS and getting it right. BMJ. 2013;346:f2812. doi: 10.1136/bmj.f2812.
48. Chappell LC. Commentary on ‘Preconception health care and congenital disorders: mathematical
modelling of the impact of a preconception care programme on congenital disorders’ by Shannon G,
Alberg C, Nacul L, Pashayan N. BJOG 2013 Jan 18. doi: 10.1111/1471-0528.12116.
49. Poston L, Chappell LC. How should women be advised on weight management in pregnancy? BMJ.
2012; 344:e2774. doi: 10.1136/bmj.e2774.
50. Chappell LC, Smith GC. Should pregnant women sleep on their left? BMJ. 2011; 342:d3659.
51. Chappell LC. Commentary: Complex medical conditions in pregnancy need appropriate multidisciplinary
input. BMJ 2009; 339:b5179.
52. Chappell LC, Shennan AH. Assessment of proteinuria. BMJ 2008; 336:968-9.
53. Chappell LC, Germain S. Commentary: Controversies in management of diabetes from preconception
to the postnatal period. BMJ 2008; 336:717-8.
RCOG Scientific Advisory Committee Paper
54. Chappell LC. Vitamin Supplementation in Pregnancy. RCOG 2009. http://www.rcog.org.uk/files/rcogcorp/SACPaper16VitaminSupplementation.pdf
Chapters
55. Chappell LC. Antioxidants for pre-eclampsia. The Yearbook of Obstetrics and Gynaecology Volume 11.
RCOG Press 2004, pp 76-92.
56. Chappell LC. Prophylaxis. ‘Pre-eclampsia’, ed. Critchley H, Maclean A, Poston L, Walker J., RCOG Press
2003, pp 276-89.
57. Ward JP, Chappell LC, Leach RM. Effects of BRL38227 and glibenclamide on small pulmonary arteries
of the rat. ‘Resistance arteries, structure and function’, ed. Mulvany MJ et al., Elsevier Science Publishers
1991, pp139-43.
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