CALL FOR EUROPEAN RESEARCH CENTERS
INTERESTED IN RECEIVING A FELLOW
FROM ANOTHER EUROPEAN COUNTRY
Name of the Institution:
Physiology, Radboud University
Nijmegen Medical Centre
Web site of the Institution: www.physiomics.eu
Contact person:
Prof.dr. René J.M. Bindels
Address:
286 Physiology, PO Box 9101
Postal code:
6500 HB
City:
Nijmegen
Country:
The Netherlands
Phone:
+31-24-3614211
Fax:
+31-24-3616413
E-mail:
r.bindels@fysiol.umcn.nl
Synopsis on research programme in Nephrology/ Dialysis/ Transplantation
(the synopsis must not exceed 3500 character –font 12, word format only-).
The Physiology team has a long-standing tradition in transport physiology in the
kidney. The principal investigators (Profs. Bindels, Hoenderop and Deen) have
made significant contributions to the field of electrolyte and water metabolism in
health and disease. Particularly the molecular causes of renal tubular transport
disorders are elucidated. To this end, inherited renal diseases including Gitelman
and Bartter Syndrome, Nephrogenic Diabetes Insipidus, Nephrolithiasis and
Hypomagnesemia are studied. In addition, the molecular mechanism of acquired
forms of renal diseases are investigated such as calcineurin inhibitors-induced
hypertension and lithium-induced nephrotoxicity. Furthermore, the molecular
effects of calciotropic hormones like vitamin D3, PTH, klotho, magnesiotropic
hormones like epidermal growth factor and vasopressin on renal electrolyte and
water handling are studied.
Cutting edge techniques are developed and applied in our on going research
projects including cell physiology, genetic screening of patient DNA, molecular
biology, fluorescence-based dynamic ion imaging, electrophysiology,
development of renal cell lines, transgenic animals and more.
The department is embedded in the Radboud University Nijmegen Medical
Centre (www.umcn.nl) and the graduate school Nijmegen Centre for Molecular
Life Sciences (www.NCMLS.eu).
Current lines of research.
-
Molecular mechanisms underlying renal inherited and acquired renal
transport disorders including sodium, calcium, magnesium and water
transporters.
-
The FGF23 – klotho – vitamin D axis as a new instrumental target to combat
the cardiovascular risk of chronic kidney disease.
-
Functional restoration of calcium-sensing receptor mutants in Familial
Hypocalciuric Hypercalcemia
-
Lithium-induced renal cyst formation.
-
Identification of the long-sought osmoreceptor in health and disease.
-
Calcineurin inhibitor-induced hypertension after kidney transplantation
-
Role of hypomagnesemia in major diseases as diabetes and hypertension
Research/es in which the Fellow will be involved.
Fellows can participate in the above mentioned research projects or other their
choice which are affiliated to our research.
Please consider that by submitting this Application you accept that it will be published
in ERA-EDTA website. This means that your e-mail address will be posted, too.
Please, return this form, as an attachment, to the following e-mail address:
fellowships@era-edta.org