Dimitrios Kouvelas Curriculum Vitae Name : Dimitrios KOUVELAS Academal Title : Professor of Pharmacology and Clinical Pharmacology Sex : Male Date of Birth : June 10th 1961 Family condition : Married, three children Home Address : 8, Stratigou Doumpiotou Street, 546 32 Thessaloniki, Greece Mail Address : P.O. Box 1532, 54006 Thessaloniki, Greece Telephone Number : +302310 999 335 (univ.), +30697 7070461 (mob.) E-mail : kouvelas@auth.gr and/or kouvelas@ med.auth.gr Work Position : Dept. of Pharmaclogy, School of Medicine - Aristotle Universityof Thessaloniki. Pharamcology "Svetozar Markovic", and Thessaloniki. Medical Specialisation Pre Graduate Studies : Visiting Professor of Pharmacology/Clinical Medical Faculty - University Kragujevac, Serbia. : Professor of Pharmacology at "Nursing Specialisation" Departments of "AHEPA" General Hospital "Hippokration" General Hospital of : General and Family Medicine : Graduate of Thessaloniki French's College "De La Salle" (1979) : Pharmacy Degree (1985) : Medicine Degree (1998) Post Graduate Studies : Computer courses on pharmaceutical research "Hellenic Productivity Centre" (1988) : Doctor of Medicine (1989) Title of PhD thesis: "Study of the opioid receptors at the neuromuscular junction" : Post doctoral studies on the CNS Pharmacology, in the “Inistituet fuer Pharmakologie und Toxikologie der Universitaet Innsbruck”, Austria (June 1995-June 1996, and 1.8.98 – 11.98) Rersearch Fields Clinical : Neuro/psychopharmacology, neurotransmition. Pharmacology, rational prescribing. Languages : English, French, Italian Member of the : Hellenic Pharmacological Society(General Secretary) : Hellenic Society of Evidence Based Medicine (Vice President) : Hellenic Society of General Practitioners : Hellenic Society of Medicinal Chemistry : Hellenic Society of Drug Abuse : Hellenic Society of Toxicology : Hellenic Society of Computer Scientists : German Society of Pharmacology, Clinical Phamracology and Toxicology : AustrianSociety of Pharmacology, Clinical Phamracology and Toxicology Report of published studies 1. A.G. Paradelis, C. Triantaphyllidis, D. Kouvelas, M. Ghiala, A. Pangalis and Ch. Sbarounis (1989): Interaction of aminoglycoside antibiotics and ketanserin at the neuromuscular junctions. Recent Advances in Chemotherapy. Antimicrobial Section 1: 8.1 - 8.2. 2. A. Papaloucas, C. Triantaphyllidis, D. Kouvelas and A.G. Paradelis (1989): Antimicrobial agents and uterus contractility. Recent Advances in Chemotherapy. Antimicrobial Section 2: 606.1 - 606.2. 3. B. Kokkas, M. Kotoula, A. Kouyoumtzis, D. Kouvelas, K. Papadopoulos and A.G. Paradelis (1990): The Influence of Methionine-5-Enkephalin on Calcium Uptake by the Bovine Aortic Media. Meth.Find.Exp.Clin.Pharmacol., 12(3): 181-184. [Cited: PubMed, Scopus, Embase, Embase, ISI] 4. D. Kouvelas, B. Kokkas, C. Papadopoulos, M. Kotoula, A. Kouyoumtzis and A.G. Paradelis (1990):Synergism of naloxone and morphine on the vascular tone. Epith. Klin. Farmacol. Farmacokin., 4:178-181. [Cited: Scopus, Embase, Embase] 5. M. Tzouveleki, D. Kouvelas, G. Salpigides, A. Pangalis, Ch. Sbarounis, A.G. Paradelis (1991): The Effect of Erythromycin Ethylsuccinate on Serum ButyrylCholinesterase Activity. Journal of Chemotherapy, (Suppl. 4): 93-94. 6. A.G. Paradelis, A. Pangalis, D. Kouvelas, M. Tzouveleki, G. Salpigides, C. Triantaphylidis (1991):Interactions of Aminoglycoside Antibiotics with Ketanserin at the Isolated Smooth Muscles of Rat Aorta. Journal of Chemotherapy, (Suppl.4): 193-194. 7. A. Pangalis, D. Kouvelas, G. Salpigides, M. Tzouveleki, C. Triantaphyllidis, A.G. Paradelis (1991):Interaction of Fazadinium Bromide with Aminoglycoside Antibiotics at the Neuromuscular Junctions. Journal of Chemotherapy, (Suppl.4): 201-202. 8. B. Kokkas, A. Kouyoumtzis, M. Kotoula, D. Kouvelas, Μ. Karamouzis, C. Papadopoulos and A.G.Paradelis (1991):The action of dynorphin 1-13 on calcium uptake by the bovine aortic media. Int.J.Immunopath.Pharmacol. 4:91-97 [Cited: PubMed, Scopus, Embase] 9. A.Pangalis, M.Tzouveleki, D.Kouvelas, A.G. Paradelis (1991): The Effect of Pefloxacin on Serum Butyrylcholinesterase Activity. Recent Advances in Chemotherapy. Antimicrobial Section 1. Proceedings of the 17th International Congress of Chemotherapy. Berlin. pp.194-195. 10. A.G.Paradelis, D.Kouvelas, A.Pangalis (1991): Pefloxacin: Absence of Neuromuscular Blocking Activity. Recent Advances in Chemotherapy. Antimicrobial Section 1. Proceedings of the 17th International Congress of Chemotherapy. Berlin. pp.196-197. 11. P.G.Papaioannidou, D.Kouvelas, C.Triantaphyllidis, A.G.Paradelis (1991): Interaction of Netilmicin and Verapamil on the contractility of the Guinea Pig Vas Deferens. Recent Advances in Chemotherapy. Antimicrobial Section 1. Proceedings of the 17th International Congress of Chemotherapy. Berlin. pp.234-235. 12. B. Kokkas, C. Papadopoulos, M. Kotoula, A. Kouyoumtzis, D. Kouvelas and A.Paradelis A. (1991): Identification of δ-opioid receptors at the smooth muscle of the bovine aortic media. Review of Clinical Pharmacology and pharmacokinetics, 5: 67-70 [Cited: Scopus, Embase] 13. B. Kokkas, C. Papadopoulos, M. Kotoula, A. Kouyoumtzis, D. Kouvelas and A.Paradelis A. (1991): The influence of isradipine on calcium uptake by the bovine aortic media (1991) dentification. Epitheorese Klinikes Farmakologias kai Farmakokinetikes, 9:181-187 [Cited: Scopus, Embase] 14. A.G. Paradelis, D. Kouvelas, A. Argyriou, P.G. Papaioannidou, G. Salpigides, S. Papaioannou, A. Pangalis (1992): Interaction of Netilmicin and Theophylline on the neuromuscular juncions. Journal of Chemotherapy, 5: 227-228. 187 [Cited: ISI] 15. D. Kouvelas, A. Argyriou, P.G. Papaioannidou, G. Salpigides, S. Papaioannou, A. Pangalis, A.G. Paradelis (1992): Interaction of netilmicin and theophylline at the smooth muscles of the isolated rat trachea. Journal of Chemotherapy, 5: 229-230. [Cited: ISI] 16. P.G. Papaioannidou, G. Salpigides, D. Kouvelas, A. Argyriou, S. Papaioannou, A. Pangalis, A.G. Paradelis (1992): An unexpected effect of netilmicin on the potassium induced contractions of the vas deferens. Journal of Chemotherapy, 5: 632-634. [Cited: ISI] 17. B. Kokkas, C. Papadopoulos, M. Kotoula, A. Kouyoumtzis, D. Kouvelas, D. Karatzas, A.G. Paradelis (1993):Felodipine and vasomotion physiology. Angiology, 44:803-809. [Cited: PubMed, Scopus, Embase, ISI] 18. B.Kokkas, D.Kouvelas, M.Gerassopoulos, M.Kotoula, A.Kouyoumtzis, C.Papadopoulos, A.G.Paradelis:Cefamandole and Ca2+ uptake by bovine aortic media. Journal of Chemotherapy, 7: 32-33. [Cited: PubMed, Scopus, Embase, ISI] 19. A. G. Paradelis, M. Tzouveleki, D. Kouvelas, G. Salpigides, A. Pangalis, L. G. Crassaris (1994): Quinolones and serum butyryl-cholinesterase activity. Journal of Chemotherapy, 7: 34-35. [Cited: PubMed, Scopus, Embase, ISI] 20. A.G. Paradelis, L.G. Crassaris, K. Delidou, A. Grigoriadou, G. Salpigides, A. Pangalis, D. Kouvelas (1994): Susceptibility of 2,000 strains of Gram-negative bacteria to four quinolones. Journal of Chemotherapy, 7(suppl.4): 56-57. [Cited: PubMed, Scopus, Embase, ISI] 21. D. Kouvelas, A. Athanasiades, A. Argyriou, A.G. Paradelis (1994): The influence of cefuroxime and ampiciline on the uterus contractility. Journal of Chemotherapy, 7: 99-100. [Cited: PubMed, Scopus, Embase, ISI] 22. G. Salpigides, A. Pangalis, D. Kouvelas, A.G. Paradelis (1994): Phamracokinetics of pefloxacin in human prostatic tissue. Journal of Chemotherapy, 7: 105-106. [Cited: PubMed, Scopus, Embase, ISI] 23. S.M. Jankovic, D. Kouvelas, A. Argyriou, V. Mirtsou_Fidani, T. Pavlidis, C. Papanikolaou, P. Papaioannidou, A.G.Paradelis (1994):Muscarinic receptor subtypes. Review of Clincical Pharmaclogy and Pharmacokinetics. 8:118-126. [Cited: Scopus, Embase] 24. S.M. Jankovic, D. Kouvelas, V. Mirtsou_Fidani, A. Argyriou, A.G.Paradelis (1995):Drirect toxicity of penicilins.Review of Clincical Pharmaclogy and Pharmacokinetics. 9:21-24. [Cited: Scopus, Embase] 25. T. Pavlidis, A.D. Alexiadis, C.A. Papanicolaou and D. Kouvelas (1995): Effect of laparoscopic cholecystectomy on liver function tests (Comparison Study). Arch. Gastroenterohepatol. 14: 26-27. [Cited: Scopus, Embase] 26. T. Pavlidis, A.D. Alexiadis, D. Kouvelas and C.A. Papanicolaou (1995): Management of Mirizzi Syndrome. Arch. Gastroenterohepatol. 14: 118-119. [Cited: Scopus, Embase] 27. A.G.Paradelis, D.Kouvelas, A.Pangalis, A. Argyriou, G. Salpigides (1995):Absence of Neuromuscular Blocking Activity of Sparfloxacin. Drugs, 49: 291292. [Cited: PubMed, Scopus, Embase] 28. T. Pavlidis, I. Spathopoulos, S.M. Jankovic, D. Kouvelas (1995): Ultrasound appearance of hepatocellular carcinoma. Medicinski Casopis, 34 (1): 21-27. 29. S.M. Jankovic, B.D. Beleslin, D. Kouvelas and G.A. Paradelis (1996):Analysis of response development in time: An isolated organ study. Acta Physiol. Pharmacol. Bulg. , 22:33-37. [Cited:PubMed, Scopus, Embase] 30. S.M. Jankovic, A. Klickovic, J. Ustevic, D. Kouvelas, V.Mirtsou-Fidani (1996): Treatment of Hypertensive Crisis in Outpatients with Drug Combinations: Case report. Review of Clinical Pharmacology and pharmacokinetics 10: 127-130. [Cited: Scopus, Embase] 31. S.M. Jankovic, D. Kouvelas and M. Mitrovic (1996): Spasmogenic action of betalactam antibiotics on the gastrointestinal tract of experimental animals. Indian J. Med. Res., 104:216-222. [Cited: PubMed, Scopus, Embase] 32. S.M. Jankovic, V. Jokovic, G. Mircic, D. Milovanovic, D. Micic-Jovanovic, D. Beleslin, D. Kouvelas, A.G. Paradelis (1996): Effects of cisapride on human gallbladder. An ultrasonographic study. Hellenic J. of Gastroenterology, 9: 35-37. [Cited: Scopus, Embase] 33. T. Pavlidis, C.A. Papanicolaou, D. Kouvelas, A.D. Alexiadis, and S.M. Jancovic (1996): Diagnostic value of tumor markers CA 19-9 and CEA in pancreatic biliary tract carcinomas. Arch. Gastroenterohepatol., 15: 5-8. [Cited: Scopus, Embase] 34. T. Pavlidis, I. Spathopoulos, S. Jankovic, D. Kouvelas (1996): Ultrasound apearace of hydatid disease of the liver. Arch. Gastroenterohepatol., 15: 13-15. [Cited: Scopus, Embase] 35. T. Pavlidis, S. Jankovic, C. Papanicolaou, D. Kouvelas (1996): Surgical management of pancreatic tumours. Medicinski Casopis LXIII (1): 19-21. 36. T. Pavlidis, S. Jankovic, C. Papanicolaou, D. Kouvelas (1996): Pancreatic pseudocystis: Observation or treatment. Medicinski Casopis LXIII (1): 27-30. 37. S.M. Jankovic, D.B. Beleslin, M.D. Ivanovic, D. Kouvelas, A. Argyriou, S. Djordjevic and V. Mirtsou-Fidani (1997): Effects of fentanyl and its analogs on electric field-stimulated contractions of rat ileum. Arch. Gastorenterohepatol. 16(2):29-32. [Cited: Scopus, Embase] 38.N. Singewald, D. Kouvelas, F. Chen, and A. Philippu (1997): The release of inhibitory amino acids in the hypothalamus is tonically modified by impulses from baroreceptors as a consequence of blood pressure fluctuations. NaunynSchmiedeberg`s Arch. Pharmacol., 356: 348-355. [Cited: PubMed, Scopus, Embase, ISI] 39.S.M Jankovic, D. Kouvelas, V. Mirtsou-Fidani (1998): Time course of isolated rat fundus response to muscarinic agonists: A measure of intrinsic efficacy. Physiol. Res. 47: 463-470. [Cited: PubMed, Scopus, Embase, ISI] 40. C. Kohlhauser,S. Kaehler, W. Mosgoeller, N. Singewald, D. Kouvelas, H. Prast, H. Hoeger and B. Lubec (1999): Histological changes and neurotransmitter levels three months following perinatal asphyxia in the rat. Life Sciences, 64(23): 21092124. [Cited: PubMed, Scopus, Embase, ISI] 41. S. M. Jankovic, P. P. Papaioannidou, D. Kouvelas, V. Mirtsou-Fidani (1999): Αstudy of the effect of Benzylpenicillin on isolated human gallbladder. Methods Find. Exp. Clin. Pharmacol. 21(4): 256-267. [Cited: PubMed, Scopus, Embase, ISI] 42. Ν. Singewald, S. Kaehler, C. Sinner, C. Thurnher, D. Kouvelas and A. Philippu (2000): Serotonin and amino acid release in the locus coeruleus by conditioned fear and inescapable shock. 6th Internet World Congress for Biomedical Sciences (INABIS 2000). 21(4): 256-267. 43. S.T. Kaehler, C. Sinner, D. Kouvelas, A. Philippu (2000): Effects of inescapable shock and conditioned fear on the release of excitatory and inhibitory amino acids in the locus coeruleus. Naunyn-Schmiedeberg`s Arch Pharmacol.,361(2):193-199. [Cited: PubMed, Scopus, Embase, ISI] 44. N. Singewald, D. Kouvelas, A. Mostafa, C. Sinner, A. Philippu (2000): Release of glutamate and GABA in the amygdala of conscious rats by acute stress and baroreceptor activation: differences between SHR and WKY rats. Brain Research, 864:138-141. [Cited: PubMed, Scopus, Embase, ISI] 45. S.M. Jancovich, V. Mirtsou-Fidani, D. Kouvelas (2000): Dexfenfluramine and fenfluramine adverse effects on heart valves: The role of pharmacovigilance. Review of Clinical Pharmacology and pharmacokinetics, 14: 28-31. [Cited: PubMed, Scopus, Embase, ISI] 46. Ν. Singewald, D. Kouvelas, S.T. Kaehler, C. Sinner and A. Philippu (2000): Peripheral chemoreceptor activation enhances 5-HT release in the locus coeruleus of conscious rats. Neuroscience lett. 28;289(1):17-20 [Cited: PubMed, Scopus, Embase, ISI] 47. D.G.Hatzichristou, A. Apostolidis, V.Tzortzis, K. Hatzimouratidis, D. Kouvelas (2001): Effects of oral phentolamine, taken before sleep, on nocturnal erectile activity: a double-blind, placebo-controlled, crossover study. Int. J. Impotence res. 13(5):303-308 [Cited: PubMed, Scopus, Embase, ISI] 48. M. Markov, D. Kouvelas, V. Mirtsou-Fidani (2001): Role of acetaldehyde (AAD) in the pathogenesis of bronchial asthma-Effects of methylxanthines. Acta Medica Bulgarica 28:101-108 [Cited: Scopus, Embase] 49. S.M. Jancovic, Z. Kovacevic, S.V. Jankovic, D. Kouvelas, P.P. Papaioannidou, V. Mirtsou-Fidani, (2001): Antipsychotic drug prescription in a Serbian long-stay psychiatric care facility. Clinical Drug Investigation, 21:679-684. [Cited: Scopus, Embase] 50. N. Gougoulias, D. Kouvelas, M. Albani (2002): Neuroprotective action of Mg2+ after acotomy in neonatal rats. Review of Clinical Pharmacology and Pharmacokinetics, 16(1):68-70. [Cited: Scopus, Embase] 51. D. Kouvelas, S.M. Jancovic, H. Karakousi, K. Tsilkos (2002): Service quality in pharmacies of the Northern Greece. Review of Clinical Pharmacology and Pharmacokinetics, 16(1):79-82. [Cited: Scopus, Embase] 52. S. Papaharitou, C. Pourzitaki, D. Kouvelas, K. Lindsay, D. Hatzichristou, G. Karakioulakis (2002): Investigation of Ca2+ channel types in human spermatozoa. Review of Clinical Pharmacology and Pharmacokinetics, 16(1):91-92. [Cited: Scopus, Embase] 53. C. Sardeli, D. Kouvelas, G. Karakioulakis, D. Hatzichristou, V. Mirtsou-Fidani (2004): Changes in the Micturicion Profile and Bladder AQP3 after ovariectomy in Rats. Review of Clinical Pharmacology and Pharmacokinetics 18(1):170-171. [Cited: Scopus, Embase] 54. G. Papazisis, K. Kallaras, A. Kaiki-Astara, T. Dagklis, D. Kouvelas, O. GuibaTziampiri (2005): neuroprotective effect of Lamotrigine in an experimental model of Perinatal asphyxia in rats. Epitheorese Klinikes Farmakologias kai Farmakokinetikes, 23(1):87-88. [Cited: Scopus, Embase] 55. D. Kouvelas Ν. Singewald, S.T. Kaehler and A. Philippu (2006): Sinoaortic denervation abolishes blood pressure-induced GABA release in the locus coeruleus of conscious rats. Neuroscience lett. 393(2-3):194-199 [Cited: PubMed, Scopus, Embase, ISI, citations] 56. C. Pourzitaki, H.Tachou, N. Raikos, D. Kouvelas, H.Tsoukali, D.Psaroulis (2006): Heroin metabolites detection in saliva and blood Review of Clinical Pharmacology and Pharmacokinetics 20(2):108-109. [Cited: Scopus, Embase] 57. E. Delvizi, C. Pourzitaki, G. Theodoridis, D. Kouvelas H. Tsoukali (2006): Rofecoxib determination in rat serum by high performance liquid chromatography.Review of Clinical Pharmacology and Pharmacokinetics 20(2): 147-149. [Cited: Scopus, Embase] 58. D. Kouvelas, E. Amaniti, C. Pourzitaki, D. Kapoukranidou, O.E. Thomareis, D.E. Vasilakos (2006): Brain lesions after aortic denervation in rats. Review of Clinical Pharmacology and Pharmacokinetics 20 (2):232-234. [Cited: Scopus, Embase] 59. D. Kouvelas Pourzitaki, C., Delvizi, E., Skepastianos, P., Andreadou, E., Tsoukali, H. (2006): Rofecoxib administration induces alterations of biochemical indicators in rat serum. Review of Clinical Pharmacology and Pharmacokinetics 20 (2):235-237. [Cited: Scopus, Embase] 60. D. Kouvelas, Μ. Hourdakis, D. Papandreou, D. Vassilakou (2006) A critical approach to fad diets and obesity drugs – the adoption of a healthy diet. Aristotle University Medical Journal, 33(1): 157-163 61. G. Papazisis, D. Kouvelas, A. Mastrogianni, A. Karastergiou (2007): Anabolic androgenic steroid abuse and mood disorder: a case report.Int J Neuropsychopharmacol 10(2):291-293. [Cited: PubMed, Scopus, Embase, ISI] Ι.F.: 5,2 62. N. Gougoulias, D. Kouvelas A. M. Albani (2007): Protective effect of PNQX on motor units and muscle property after sciatic nerve crush in neonatal rats. Pharmacol Res. 55 (5):370-377. [Cited: PubMed, Scopus, Embase, ISI] Ι.F.: 2,42 63. G. Papazisis, Kallaras K, Kaiki-Astara A, Pourzitaki C, Tzachanis D, Dagklis T, D. Kouvelas (2007): Neuroprotection by lamotrigine in a rat model of neonatal hypoxic-ischaemic encephalopathy.Int J Neuropsychopharmacol. 2007 Sep 26; 1-9 [Epub ahead of print] PMID: 17897482 [Cited: PubMed, Scopus, Embase, ISI] Ι.F.: 5,42 64. T. G. Tzellos, D. Kouvelas (2007)Topical tacrolimus and pimecrolimus in the treatment of cutaneous lupus erythematosus: an evidence-based evaluation. Eur J Clin Pharmacol. 2007 Dec 20; [Epub ahead of print] PMID: 18157526 [Cited: PubMed, Scopus, Embase, ISI] Ι.F.: 2,03 65. D. Kapoukranidou, I. Kalpidis, E. Amaniti, D. Kouvelas, D. Vasilakos, M. Albani (2007): Muscle regeneration following local anesthetic myotoxic insult. Morphometry evaluation. Epitheorese Klinikes Farmakologias kai Farmakokinetikes25(1), pp. 49-51. [Cited: Scopus, Embase] 66. H. Tachou, C. Pourzitaki, G. Dermatis, N. Raikos, E. Tsoukali, D. Kouvelas (2007): Cocaine metabolism and detection in saliva and blood. Epitheorese Klinikes Farmakologias kai Farmakokinetikes 25 (1), pp. 114-115. [Cited:Scopus, Embase] 67. K. Koskinas, T.G. Tzellos, K.Gougoulias, G. Gougoulias, C. Papakonstantinou, D. Kouvelas (2007): Simvastatin-induced rhabdomyolysis: a case study on clinical- decision making based on the evidence-based medicine approach. Arch Med Sci. 3: 267-271. [Cited: Scopus, Embase, ISI] Ι.F.: 2,78. 68. G. Papazisis, C. Pourzitaki, C. Sardeli, A. Lallas, A. Amaniti, D. Kouvelas (2007): Effects of deferoxamine on the excitatory amino acids release and the histological outcome following hypoxia-ischemia in neonatal rats. Pharmacol Res. 57(1): 73-78 [Cited: PubMed, Scopus, Embase, ISI] Ι.F.: 2,42 69. D. Kouvelas, C. Pourzitaki, G. Papazisis, Th. Dagklis, K. Dimou M. Kraus, (2008): Nandrolone abuse decreases anxiety and impairs memory in rats via central androgenic receptors. Int. J. Neuropsychopharmacol. 14:1-10 [Cited: PubMed, Scopus, Embase, ISI] Ι.F.: 5,42 70. E.Kouvelou, C.Pourzitaki, F.Aroni, G. Papazisis , D.Kouvelas (2008): Acute psychosis induced by clarithromycin in a healthy adult. J.Clin.Psychopharmacol. 28(5):579-80 [Cited: PubMed, Scopus, Embase, ISI]Ι.F.: 5,145 71. G. Papazisis, T. Tzellos, D. Kouvelas (2008) Managing Trichotillomania: No need to pull your hair out. Evidence Based Medicine, BMJ. 13(3):66-7 [Cited: PubMed, Scopus, Embase, ISI] 72. T. Tzellos, G. Papazisis, G. Amaniti, D. Kouvelas (2008)Efficacy of pregabalin and gabapentin for neuropathic pain in spinal-cord injury: an evidence-based evaluation of the literature. Eur J Clin Pharmacol. 2008 64(9):851-8. PMID: 18607580 73. Ch. Sardeli, Th.Tzellos, E. Amaniti, G. Papazisis, K. Karakoulas, Ch. Pourzitaki, D. Kouvelas (2008) Deciding on the best treatment strategy for recurrent febrile seizures: An evidence-based medicine approach Review of Clinical Pharmacology and Pharmacokinetics, International Edition 22 (2): 320-1 74. Ch. Pourzitaki, H. Logotheti,Ch. Sardeli,G. Papazisis, P. Arampatzis, D. Kouvelas(2008) Pregabalin combined with epidural analgesia in chronic cancer pain patients. Review of Clinical Pharmacology and Pharmacokinetics, International Edition 22 (2): 308-309 75. Ch. Pourzitaki, Th.Tzellos, Ch. Sardeli, G. Papazisis, E. Amaniti, D. Kouvelas (2008) Evidence-based evaluation of emergency care treatment algorithms: 15 Dominant myths.ReviewofClinicalPharmacologyandPharmacokinetics, InternationalEdition22 (2): 302-3 76. M Saitis, G. Papazisis, K. Katsigianopoulos, D. Kouvelas (2008) Aripiprazole resolves amisulpride and ziprasidone-induced hyperprolactinemia. Psychiatry and Clinical Neurosciences 62(5):624. 77. D. Kouvelas, E.Amaniti, Ch. Pourzitaki, D. Kapoukranidou, O. Thomareis, G.Papazisis, D. Vasilakos(2009) Baroreceptors discharge due to bilateral aortic denrvation evoces acute neuronal damage in rat brain. Brain Research Bulletin 79(2):142-6 (ImpactFactor: 2.481) 78. K Karakoulas, V. Grosomanidis, E.Amaniti, D. Kouvelas, C. Skourtis, D. Vasilakos(2009) The effect of intra-abdominal hypertension alone or combined intraabdominal hypertension-endotoxemia in cerebral oxygenation in a porcine model. Hippokratia.12(4):225-9. 79. K.A. Toulis, Th.Tzellos2, D. Kouvelas, D.G. Goulis (2009) Gapapentin for the treatment of hot flushes in women with natural or tamoxifen-induced menopause: a systematic review and a meta-analysis.ClinTher.31(2):221-35. Review 80. G. Papazisis, Th. Tzellos, D. Tahmatzidis, K. Dolianitis, D. Kouvelas (2009) Late-onset clozapine-induced hypothermia accompanied with electrocardiogram Osborn waves.Journal of Clinical Psychopharmacology 29(2):183-5(Impact Factor: 5.145) 81. D. Kouvelas, Ch. Pourzitaki, G. Papazisis, K. Tsilkos, M. Chourdakis, M.M. Kraus (2009) Chronic aortic denervation decreases anxiety and impairs social memory in rats.Life Science 85(15-16):602-8(Impact Factor: 2.616) 82.M. Chourdakis, S. Kellidou, G. Papazisis, C. Sardeli, A. Argyriou, D. Kouvelas(2010) Possible interactions with drugs of herbals used for weight loss enhancement. Review of Clinical Pharmacology and Pharmacokinetics, International Edition 24(2): 128-9 83.G. Papazisis, Th. Tzellos, K. Toulis, D. Goulis, C. Sardeli, M. Chourdakis, D. Kouvelas(2010) Safety/tolerability of α2δ ligand pregabalin in the treatment of fibromyalgia: An evidence based evaluation. Review of Clinical Pharmacology and Pharmacokinetics, International Edition24 (2):181-182 84.G. Papazisis, K. Kallaras, A. Kaiki-Astara, Th. Tzellos, C. Sardeli, Pourzitaki, M. Chourdakis, D. Kouvelas(2010)Long term effects of oxcarbazepine in brain hypoxiaischemia: A study in neonatal rats. Review of Clinical Pharmacology and Pharmacokinetics, International Edition24 (2):193-4. 85.K. Toulis, Th. Tzellos, D. Kouvelas, C. Sardeli, G. Papazisis, M. Chourdakis, D. Goulis, (2010) Safety and tolerability of α2δ ligand gabapentin in treating hot flashes: An evidence-based systematic review and meta-analysis. Review of Clinical Pharmacology and Pharmacokinetics, International Edition24(2):227-8. 86.Th. Tzellos, G. Papazisis, K.Toulis,C. Sardeli, D. Kouvelas(2010) A2δ ligands gabapentin and pregabalin: Future implications in daily clinical practice. Hippokratia14(2):71-5. 87.P. Pavlidis, V. Nikolaidis, H. Gouveris,E. Papadopoulos, G. Kekes, D. Kouvelas (2010) Ototoxicity caused by once- and twice-daily administration of amikacin in rabbits. International Journal of Pediatric Otorhinolaryngology74 (4): 361-4. 88.M. Chourdakis, D. Papandreou, P. Malindretos, D. Vassilakou, N. Papastergiou,D. Tantsidis, D. Kouvelas(2010) Effect of Greek orthodox Easter holidays on body weight gain. Nutrition and Food Science40 (1):49-54.