赣 南 医 学 院 教 案
教研室：Department of Biochemistry and Molecular Biology
课程名称
授课内容
Biochemistry
授课专业
Chapter 2 Structures and Functions of
Nucleic Acids
教师姓名： Huang Yuping
Clinical medicine major
授课学时
4
【Master】
1．the structure and composition of nucleic acids.
2．the Secondary structure of DNA and types of RNA, the structure and
function of each kind of RNA
教学目的
3．The concept of denaturation and renaturation of nucleic acids ,the
concept of Tm
【Understand】
1．chemical properties of nucleic acids.
2．Superhelix of DNA, function of DNA
3． The concept of hybridization.
【Know】
1. the concept and function of small non-messenger RNA
1. the structure and composition of nucleic acids.
教学重点
教学难点
2. the Secondary structure of DNA and types of RNA, the structure and
function of each kind of RNA
3. The concept of denaturation and renaturation of nucleic acids ,the
concept of Tm
The structure and function of RNAs
1． Theaching aid: computer, projector, mike, chalk, ferule, multimedia
教具和媒
体使用
courseware
2. Theaching means: utilize modernization teaching means and methods,
make good courseware, combine pictures with words well; integrate
languge expression, apporiate writing and teaching with multimedia.
1． Introduce the content of this chapter and tell the students the emphases
of this chapter.
教学方法
2． Give picture of nucleic acid to explain its structure and
compositions ,then fetch out the structure and function of DNA and
RNA .
1．Review the structure and function of protein, then introduce another
biomacromolecule---nucleic acid .
2．Teach new teaching content
教学过程
（See multimedia courseware in detail）
Section 1 The Monomeric Units of Nucleic Acids----Nucleotides
(1)Structure of nucleotides
(2)Properties of nucleosides and nucleotides
Section 2. Structure of DNA
(1) Primary structure of DNA
(2)Secondary structure of DNA
(3)Superhelix of DNA
Section 3 .Structure and function of RNA
(1) Structure of RNA
(2) Types and functions of RNAs
Section 4. Properties of nucleic Acids
(1) the common chemical properties of nucleic acid
(2) denaturation of DNA
(3) renaturation of DNA and hybridization
讲授新进展
内容
the study and the new advance of research about RNAi
⑴ Berg J M，Tymoczko J L，Stryer L. 2002. Biochemistry. 5th Edition.
参考书籍
思考题或/及
作业
New York:W.H. Freeman Publishers.
⑵Devlin T M.. 2002. Textbook of Biochemisrty with Clinical Correlations.
New York: Wiley-Liss.
⑶ Robert K. Murray, Daryl K. Granner, Peter A. Mayes，et al. 2003.
Harper’s Biochemistry. Stamford：McGraw-Hill.
1. Gather up the structure and function of RNAs
2. describe the double helix of DNA
The key points are recited in the chapter: the primary structure of nucleic
acid , the chemical compositions of nucleic acid and the connecting method
of each other . the secondary structure of DNA , the functions of three kinds
课后总结
of RNA and each structure ,the splicing of mRNA, denaturation and
renaturation of DNA ,the concept of Tm and annealing .
The other points are recited in the chapter: the function of nucleic acid ,the
function of nucleotide , the multiformity of DNA double helix, superhelix
of DNA, the method how DNA form chromatin , the function of DNA,
other kinds of RNA, the common chemical properties of nucleic acid , the
hybridization of nucleic acid .