Yu-Shih Yang 2014 Yu-Shih Yang, M.D., Ph.D. Professor Department of Obstetrics and Gynecology National Taiwan University and the Hospital Education and Training: 1969-1976 1984-1990 1978-1982 1987-1989 National Taiwan University (NTU), School of Medicine NTU, Graduate institute of Clinical Medicine Dept. of OB/GYN, NTU Hospital Dept. of OB/GYN, University of California, Irvine M.D. Ph.D. Residency Post-doctoral fellowship Academic Appointments: 1982-1984 1984-1989 1989-1995 1995-present 1994-2005 2005-2011 Dept. of OB/GYN, National Taiwan University Dept. of OB/GYN, National Taiwan University Dept. of OB/GYN, National Taiwan University Dept. of OB/GYN, National Taiwan University Division of Reproductive Endocrinology and Infertility, Dept. of OB/GYN, NTU Hospital Dept. of OB/GYN, National Taiwan University and the Hospital Clinical Instructor Assistant Professor Associate Professor Professor Division Director Chairman Professional Memberships: 1978 1980 1982 1983 1983 The Formosan Medical Association The Taiwan Association of Obstetrics and Gynecology (TAOG) The Endocrinology Society, R.O.C. The American Society of Reproductive Medicine (ASRM) The American Association of Gynecological Laparoscopists (AAGL) 1984 1984 1988 The Society of Ultrasound in Medicine, R.O.C. The Laser Medicine Society, R.O.C. The Society for the Study of Reproduction (SSR) 1 Yu-Shih Yang 2014 1988 1990 1995 2004 The American Society of Andrology (ASA) The Taiwan Society of Reproductive Medicine (TSRM) The Taiwanese Menopause Society The European Society of Human Reproduction and Embryology (ESHRE) Professional Activities: ◎Taiwan Association of Obstetrics and Gynecology(TAOG) 1996-1998 Secretary General 1998-2000 Supervisor 2000-2002 Vice President 2004-2007 President 2007-present Fellow ◎Taiwan Society of Reproductive Medicine(TSRM) 1990-1994 Executive Board Member 1990-1994 Chairman, Journal Committee 1994-1996 President 2004- present Fellow ◎Taiwanese Menopause Society 1997-1999 Executive Board Member ◎Formosan Medical Association 2010-present Executive Board Member ◎Asia-Oceania Federation of Obstetrics and Gynecology(AOFOG) 2004-2007 Council Member 2006-2009 Treasurer 2009-2011 Vice President 2011-2013 President Honors and Awards: 1982 1983 1984 1987 The best Chief Resident , NTUH Prize paper, The Endocrinology Society, R.O.C. Prize paper, TAOG Prize paper, The Society of Ultrasound in Medicine, R.O.C. 1987 1988 1991 Prize paper, TAOG Prize paper, TAOG Prize paper, The Taiwan Medical Foundation 2 Yu-Shih Yang 2014 1992 1994 1995 1995 1998 2002 2003 2007 2011 2012 Outstanding Award in Medicine, The Ching-Sing Medical Education Foundation Prize paper, TSRM “The excellent teacher”, NTU, School of Medicine Prize paper, Wu Jen Tie Lan Medical Foundation Prize poster preliminary winner, 16th World Congress on Fertility and Sterility “The best clinical teacher”, The Foundation of Alumni Association of NTU, School of Medicine Award for the Outstanding Innovative Teaching Material, NTUH Outstanding Research Award for Excellent Contribution in Medical Research, NTUH President of the Organizing Committee of the 22nd Asian and Oceanic Congress of Obstetrics and Gynecology (AOCOG 2011) Honorary Fellow, Korean Society of Obstetrics and Gynecology Editorial Board: 1990-1994 1990-2000 2004-2007 J Reprod Infertil Archives of Andrology ( SCI Journal) Taiwanese J Obstet Gynecol ( SCI Journal) 2009-2013 J Formos Med Assoc ( SCI Journal) Achievements: Published more than 280 scientific papers on international peer reviewed journals and 55 book chapter, monographs or book editor since 1982 3 Yu-Shih Yang 2014 Publications: 1. Yang YS, Lee TY (1982): Simultaneous determination of serum total estrogens (TE) and human placental lactogen (hPL) by enzyme-immunoassay (EIA) in normal and high-risk pregnancies. J Obstet Gynecol ROC 21:151-162. 2. Su SL, Yang YS, Lee TY (1982): Three minute assay of urinary estriol in pregnant women. J Obstet Gynecol ROC 21:163-168. 3. Lien YR, Yang YS, Lee TY (1983): Myomectomy and fertility. J Obstet Gynecol ROC 22:45-53. 4. Ko TM, Yang YS, Chen HY, Lee TY(1983): Ultrasonic scanning of ovarian follicular development-a preliminary report. J Obstet Gynecol ROC 22:191-202. 5. Huang SC, Chen HC, Kurman RJ, Yang YS, Wen HK, Hsieh CY, Wei PY, How SW, Chen TY, Ouyang PC (1984): Secretion of human chorionic gonadotropin and alpha-fetoprotein by an ovarian germ cell tumor of apparent yolk sac origin. Gynecol Oncol 18:240-246. 6. Kao KL, Yang YS, Lee CJ, Shieh HT, Lee EF, Chen YC (1984): Granulocytic sarcoma of the cervix uteri. J Formosan Med Assoc 83:618-625. 7. Yang YS, Lee TY (1984): Pregnancy in 45,X/46,XX mosaicism. J Obstet Gynecol ROC 23:249-253. 8. Ko TM, Yang YS, Lee TY, Chen HY (1985): Ovarian follicular growth monitored by ultrasound. J Formosan Med Assoc 84:929-935. 9. Lee TY, Yang YS (1985): Current overview and reflection on gynecologic surgery. Transactions of the China Section, International College of Surgeons. 1:16-23. 10. Yang YS, Ko TM, Hsieh FJ, Lien YR, Lee TY, Chen HY (1986): Application of ultrasound for follicular growth monitoring in artificial insemination with donor semen(AID): a comparative study. J Ultrasound Med ROC 3:62-66. 11. Yang YS, Ko TM, Lee TY (1986): Prediction and detection of ovulation: a comparison of direct and indirect methods. J Formosan Med Assoc 85:667-673. 12. Yang YS, Ko TM, Liu CH, Lien YR, Lee TY (1986): Human menopausal gonadotropin(hMG) for induction of ovulation. J Obstet Gynecol ROC 25:130-143. 13. Ko TM, Chang DY, Yang YS, Lee TY (1986): Rubella infection in females of reproductive age and newborns in Taiwan. J Formosan Med Assoc 85:856-861. 14. Lien YR, Hsu CC, Yang YS, Chen YP, Lee TY (1986): Cesarean section: changing incidence and indications at National Taiwan University Hospital. J Obstet Gynecol ROC 25:196-206. 15. Hsu MC, Lien YR, Yang YS, Chang YK, Lee Y (1987): Etiological study of 112 patients with primary amenorrhea. J Formosan Med Assoc 86:536-542. 16. Yang YS, Huang JC, Lee TY (1987): Variants of 61 cases with gonadal dysgenesis. Asia-Oceania J Obstet Gynecol 13:151-159. 17. Hsu MC, Yang YS, Lien YR, Lee TY (1987): Etiological study of 112 patients with secondary amenorrhea. J Obstet Gynecol 26:94-104. 18. Yang YS, Ko TM, Lien YR, Hsu MC, Chang YK, Lee TY (1987): Sequential use of clomiphene citrate and human menopausal gonadotropin for induction of ovulation. J Formosan Med Assoc 86:1049-1054. 19. Yang YS, Ko TM, Lee TY (1987): Ovulation induction in patients with polycystic ovarian 4 Yu-Shih Yang 2014 disease: a comparison between using human urinary follicle-stimulating hormone and human menopausal gonadotropin treatment. J Obstet Gynecol ROC 26:245-255. 20. Yang YS, Hsu CC, Lien YR, Ko TM, Peng SY, Hsieh FJ, Chow SN, Huang SC, Lee TY, Wei PY (1988): The program for in vitro fertilization and embryo transfer at National Taiwan University Hospital. J Formosan Med Assoc 87:116-118. 21. Hsu CC, Yang YS, Ko TM, Hsieh FJ, Chen YP, Lee TY (1988): Immunosuppression in pregnant mice detected by rosette inhibition test using monoclonal antibody. J Obstet Gynecol ROC 27:85-93. 22. Yang YS (1988): Acrosome reaction of human spermatozoa and in vitro fertilization. Proceedings of the 1988 Science, Engineering and Technology Seminars S5-6-S5-9. 23. Lien YR, Kuo PL, Yang YS, Lee TY (1988): Etiological factors and subsequent reproductive performance of 102 couples with a prior history of habitual abortion. J Obstet Gynecol ROC 27:153-162. 24. Peng SY, Hsu CC, Yang YS, Lien YR, Lee TY (1988): Effect of serum and culture medium on the in vitro development of mouse embryo. J Obstet Gynecol ROC 27:202-209. 25. Yang YS, Lee TY, Chang FM, Ko TM (1988): Chlamydia trachomatis infection in pregnant women. J Formosan Med Assoc 87:1177-1181. 26. Huang SC, Yang YS, Lee TY, Yang KH (1988): A study on prolactin in toxemia of pregnancy. J Obstet Gynecol ROC 27:223-229. 27. Yang YS, Rojas FJ, Stone SC (1988): Acrosome reaction of human spermatozoa in zona-free hamster egg penetration test. Fertil Steril 50:954-959. 28. Hwang WJ, Hsu MC, Yang YS, Lien YR, Lee TY(1989): Reproductive performance and operative outcome of double uterus-analysis of 50 cases. J Obstet Gynecol ROC 28:24-30. 29. Lin SJ, Hsu CC, Lien YR, Yang YS, Wang TR, Chuang SM, Lee TY(1989): Human sperm chromosome analysis in primary infertility: a preliminary report. J Formosan Med Assoc 88:567-578. 30. Hwang JL, Hsu MC, Yang YS, Lee TY(1989): Hypertensive disorders in pregnancy: analysis of 110 cases. J Formosan Med Assoc 88:572-578. 31. Kuo PL, Lien YR, Lin HR, Yang YS, Lee TY (1989): Sperm penetration assay using cryopreserved hamster oocytes. J Obstet Gynecol ROC 28:80-89. 32. Huang LW, Peng SY, Lin HR, Yang YS, Lien YR, Lee TY, Hsieh CY (1989): Development of mouse embryos in four sera sources: Comparing the effect of heat inactivated with non-heat inactivated sera. J Obstet Gynecol ROC 28:90-97. 33. Huang LW, Yang YS, Hsu MC, Lee TY, Chen MT(1989): Congenital uterovaginal agenesis-review of 53 cases. J Obstet Gynecol ROC 28:133-140. 34. Feng CY, Chow CY, Yang YS, Ouyang PC, Lee TY (1989): A comparison of three different methods in the qualitative measurement of beta-subunit of human chorionic gonadotropin. J Obstet Gynecol ROC 28:147-153. 35. Chang DY, Lin BJS, Yang YS, Lee TY (1989): The role of hemoglobin A1C in obstetrics. J Obstet Gynecol ROC 28:154-165. 36. Lee TY, Hsu MC, Yang YS(1989): Antisperm antibodies in infertility. In; Chen C, Tan SL and Cheng WC eds. Recent Advances in the Management of Infertility. Singapore: McGraw-Hill Book Co., pp 311-326. 5 Yu-Shih Yang 2014 37. Yang YS, Hsu MC, Lien YR, Lee TY (1989): Association of Chlamydia trachomatis with tubal infertility. J Obstet Gynecol ROC 28:186-191. 38. Lien YR, Kou PL, Liu CH, Lin HR, Yang YS, Lee TY (1989): Gamete intrafallopian transfer in the treatment of infertility: the preliminary experiences at NTUH. J Obstet Gynecol ROC 28:214-222. 39. Yang YS (1990): The management of abnormal menstrual cycles. J Formosan Med Assoc 2(CME Series): 394-396. 40. Lee TY, Yang YS (1990): Recent advances in human in vitro fertilization and related reproductive technology. J Formosan Med Assoc 2(CME Series):276-279. 41. Yang YS (1990): Programming ovarian stimulation in human in vitro fertilization cycles. J Formosan Med Assoc 2(CME Series):280-284. 42. Yang YS (1990): Climacteric Syndrome: Pathophysiology and management. J Formosan Med Assoc 2(CME Series):836-840. 43. Tsaur GT, Lien YR, Yang YS (1990): Artificial insemination: intracervical Versus intrauterine insemination by "Swim-up" sperm preparation. J Obstet Gynecol ROC 29:211-220. 44. Hwang WJ, Yang YS, Lee TY (1990): Artificial insemination. Tzu-Chi Med J 2:93-94. 45. Ko TM, Yang YS, Tseng LH, Ho HN, Liu CH, Hsieh FJ, Chen HY, Lee TY(1991): Selective reduction of multiple pregnancies in the first trimester or early second trimester. J Formosan Med Assoc 90:493-497. 46. Yang YS, Lee TY (1991): Correlation between sperm penetration assay and acrosome reaction in sperm treated with human follicular fluid. J Formosan Med Assoc 90:514-516. 47. Lin MC, Kao MC, Pu YS, Tsai TC, Yang YS (1991): The effects of low energy laser on sperm characteristics in vitro. J Urol Assoc ROC 2:472-476. 48. Yang YS, Ho HN, Lien YR, Lin HR, Hsieh CY, Lee TY (1991): Treatment of patients with unexplained infertility: Gamete intrafallopian transfer (GIFT) versus tubal embryo transfer (TET). J. Formosan Med Assoc 90:547-550. 49. Yang YS (1991): The study on human in vitro fertilization and related reproductive technology. Dissertation thesis, Graduate Institute of Clinical Medicine. National Taiwan University, Taipei, Taiwan, ROC. 50. Yang YS, Hwang JL, Ho HN, Kuo YS, Lien YR, Lee TY (1991): Pregnancy following oocyte donation and tubal embryo transfer in patients with premature ovarian failure: report of two cases. J Formosan Med Assoc 90:688-692. 51. Yang YS, Hwang JL, Ho HN, Lien YR, Lin HR, Chiu YH, Lee TY (1991): Translaparoscopic tubal embryo transfer: preliminary experience at National Taiwan University Hospital. Asia-Oceania J Obstet Gynecol. 17:255-259. 52. Yang YS, Ho HN, Lien YR, Hwang JL, Melinda S, Lin HR, Lee TY (1991): The use of a long-acting gonadotropin-releasing hormone analog (D-Trp-6-LHRH)for improvement of ovarian stimulation in assisted conception programs. J Formosan Med Assoc. 90:1081-1085. 53. Lin MC, Chen CJ, Yang YS, Tsai TC (1991): A new method for recovery of motile sperm using osmolarity-gradient technique. Arch Androl. 27:177-184. 54. Yang YS (1991): Assessment of sperm function and clinical application. Cont Med Edu 1:626-630. 6 Yu-Shih Yang 2014 55. Hwang JL, Yang YS, Ho HN, Melinda S, Lien YR, Lin HR, Hsieh CY, Lee TY (1991): Translaparoscopic tubal embryo transfer as a treatment of unexplained infertility. J Obstet Gynecol ROC. 30:198-202. 56. Ho HN, Gill TJ III, Hsieh CY, Yang YS, Lee TY (1991): The prevalence of recurrent spontaneous abortions, cancer and congenital anomalies in the families of couples having recurrent spontaneous abortions or gestational trophoblastic tumors. Am J Obstet Gynecol. 165:461-466. 57. Yang YS (1992): New frontier of reproductive technology. Cont Med Edu 2:422-427. 58. Lin MC, Tsai TC, Yang YS (1992): Measurement of viscosity of human semen with a rotational viscometer. J Formosan Med Assoc 91:419-423. 59. Chen SU, Yang YS, Ho HN, Hwang JL, Lien YR, Lin HR, Hsieh CY, Lee TY (1992): Comparison of long-term versus three-day leuprolide for ovarian stimulation in human in vitro fertilization program. J Reprod Infertil 1:9-16. 60. Melinda S, Yang YS, Ho HN, Hwang JL, Chen SU, Lin HR, Hsieh CY, Lee TY (1992): The effects of sperm concentration and motility toward fertilization rate in humans during an in vitro fertilization program. J Reprod Infertil 1:17-22. 61. Hwang JL, Ho HN, Yang YS, Hsieh CY, Lee TY, Gill TJ III (1992): The role of blocking factors and antipaternal lymphocytotoxic antibodies on the success of pregnancy in patients with recurrent spontaneous abortion. Fertil Steril 58:691-696. 62. Ho HN, Chen HF, Yang YS, Lin HR, Melinda S, Lien YR, Liu CH, Hwang JL, Hsieh CY, Lee TY (1992): Pregnancy after transfer of frozen-thawed human embryos. J Formosan Med Assoc 91:708-711. 63. Chen SU, Yang YS, Ho HN, Ko TM, Hsieh FJ, Lee TY (1992): Combined cornual pregnancy and intrauterine twin pregnancy after in vitro fertilization and embryo transfer (IVF-ET)-a case report. J Formosan Med Assoc 91:1002-1005. 64. Lien YR, Kuo PL, Lin HR, Yang YS, Hsieh CY, Lee TY (1992): Cryopreservation of two-cell mouse embryos with 1,2-propanediol with and without sucrose: the establishment of an animal model for human embryo cryopreservation. J Obstet Gynecol ROC 31:26-31. 65. Yang YS, Melinda S, Ho HN, Hwang JL, Chen SU, Lin HR, Huang SC, Lee TY (1992): Effect of the number and the depth of embryos transferred and unilateral or bilateral transfer in tubal embryo transfer (TET). J Assisted Reprod Genet 9:534-538. 66. Chen SU, Yang YS, Ho HN, Hwang JL, Hong TS, Lin HR, Huang SC, Lee TY (1993): Microinjection of human spermatozoa into the perivitelline space of hamster eggs: comparison with the zona-free hamster egg penetration of human spermatozoa. Arch Androl 30:201-207. 67. Ho HN, Yang YS, Gill TJ III (1993): Controversy about immunotherapy. Fertil Steril 59:1138-1139. 68. Chen HF, Hsieh FJ, Yang YS, Ko TM, Chen HY (1993) : Sonographic evaluation of thickness, type of endometrium and endometrial peristalsis: relation to serum estradiol level and pregnancy outcome in infertile patients. J Med Ultrasound 1:20-25. 69. Chan DF, Yang YS, Ho HN, Hwang JL, Chen SU, Lin HR, Hsieh CY, Lee TY(1993): Programming controlled ovarian hyperstimulation in in vitro fertilization and embryo transfer. J Reprod Infertil 2:18-24. 70. Chu GP, Yang YS, Chen SU, Ho HN, Chen HF, Lin HR, Huang SU, Lee TY (1993): The correlation between in vitro fertilization and sperm motility assessed by computer-assisted 7 Yu-Shih Yang 2014 semen analyzer (CASA). J Reprod Infertil 2:10-17. 71. Yang YS, Chen SU, Hwang JL, Ho HN, Lin HR, Lee TY (1993): Analysis of human in vitro fertilization failure. J Formosan Med Assoc 92:122-127. 72. Lee TY, Yang YS, Tseng LH, Ko TM, Hsu MC, Chuang SM (1993): Norplant-2 subdermal contraceptive system: experience in Taiwan. J Formosan Med Assoc 92:446-450. 73. Sheu BC, Chen SU, Ho HN, Chen HF, Chao KH, Huang SC, Lee TY, Yang YS (1993): Double uterus associated with obstructed hemivagina and ipsilateral renal agenesis: report of 2 cases. J Reprod Infertil 2:39-44. 74. Lin HH, Yang YS, Yeh TS, Chen D, Shyu MK, Lee TY (1993): Evaluation of oxytocin and prostaglandin F2 in termination of pregnancy after first trimester. J Obstet Gynecol ROC 32:15-20. 75. Yang YS, Chen SU, Ho HN, Chen HF, Chao KH, Lin HR, Huang SC, Lee TY (1993): Comparison of using different gonadotropin-releasing hormone analogs (GnRHa) as adjuvant therapy for ovarian stimulation in an in vitro fertilization and embryo transfer (IVF-ET) program. J Reprod Infertil 2:56-67. 76. Yang YS, Chen SU, Ho HN, Chen HF, Chao KH, Lin HR, Lin MC, Chiang HS (1993): Correlation of acrosome reaction and fertilization rate in human ejaculated and epididymal spermatozoa. J Reprod Infertil 2:75-82. 77. Lien YR, Chen HF, Yang YS, Ho HN, Lin HR, Chen SU, Lee TY, Huang SC (1993): Trisomy 5 after transfer of frozen-thawed human embryos. J Reprod Infertil 2:83-86. 78. Chao KH, Chen HF, Chen SU, Lin HR, Yang YS, Ho HN, Huang SC, Lee TY (1993): Oocyte donation: an alternative therapy for recurrent spontaneous abortion due to maternal chromosomal anomaly. J Reprod Infertil 2:87-90. 79. Yang YS, Chen SU, Ho HN, Chen HF, Chao KH, Lin HR, Huang SC, Lee TY (1993): The protocal of nonanonymous oocyte donation: preliminary results at National Taiwan University Hospital. J Reprod Infertil 2:123-131. 80. Shen CY, Chang SF, Yang SL, Wu CW, Yang YS, Ho HN, Huang ES (1994): Cytomegalovirus is present in semen from a population of men seeking fertility evaluation. J Infect Dis 169:222-3. 81. Hsu ML, Yang YS, Ho HN, Huang SC, Lee TY (1994): Pregnancy after gonadotropin ovulation induction and intra uterine insemination of husband semen in a woman with Kallmann syndrome. J Reprod Infertil 3:19-21. 82. Ho HN, Chen SU, Yang YS, Huang SC, Lee TY, Gill TJ III (1994): Age, environment, and lymphocyte immunization influence the spontaneous resorption rate in the CBA/J x DBA/2J mouse model. Am J Reprod Immunol 31:47-51. 83. Ho HN, Yang YS, Hsieh RP, Lin HR, Chen SU, Chen HF, Huang SC, Lee TY, Gill TJ III (1994): Sharing of human leukocyte antigen (HLA) in couples with unexplained infertility affects the success of in vitro fertilization and tubal embryo transfer. Am J Obstet Gynecol 170:63-71. 84. Yang YS, Chen SU, Ho HN, Chen HF, Lien YR, Lin HR, Huang SC, Lee TY (1994): Total acrosin activity of human spermatozoa did not correlate with IVF. Arch Androl 32:13-19. 85. Chen HF, Ho HN, Chen SU, Lien YR, Chao KH, Lin HR, Huang SC, Lee TY, Yang YS (1994): Co-culture with vero cell monolayer maintains the motility of asthenozoospermic semen samples. Hum Reprod 9:1276-1280. 8 Yu-Shih Yang 2014 86. Chen YBT, Cheng TJ, Lin HH, Yang YS (1994): Spatial W-plasty full thickness skin graft for neovaginal reconstruction. Plast Reconst Surgery 94: 727-731. 87. Yang YS, Chen SU, Ho HN, Hwang JL, Lin HR, Huang SC, Lee TY (1994): Sperm acrosin activity and fertilization of human oocytes in vitro. In: Rodriguez Armas O, Baumgartner W and Burgos L eds. Fertility and Sterility: Progress in research and practice. London: Parthenon publishing, chapter 13 : 119-127. 88. Chen HF, Ho HN, Chen SU, Chao KH, Lin HR, Huang SC, Lee TY, Yang YS (1994): Peptides extracted from Vero cell cultures overcome the blastocyst block of mouse embryos in a serum-free medium. J Assist Reprod Genet 11:165-171. 89. Cheng WF, Ho HN, Yang YS, Huang SC (1994): Abdominal pregnancy after gonadotropin superovulation and intrauterine insemination: a case report. Am J Obstet Gynecol 171:1394-1395. 90. Lin YF, Chen HF, Yang YS, Ho HN, Chung SM, Hsieh FJ (1994): Hormonal studies and Doppler flow imaging of ovarian lipoid cell tumor: report of two cases. J Formosan Med Assoc 93:954-957. 91. Yang YS, Chen SU, Ho HN, Chen HF, Chao KH, Lin HR, Huang SC, Lee TY (1995): Correlation between sperm morphology using strict criteria in original semen and swim-up inseminate and human in vitro fertilization. Arch Androl 34:105-113. 92. Ho HN, Wu MY, Chen HF, Chao KH, Yang YS, Huang SC, Lee TY, Gill TJ III (1995): In vivo CD3+CD25+ lymphocyte subpopulation is down-regulated without increased serum soluble interleukin-2 receptor (sIL-2R) by gonadotropin releasing hormone agonist (GnRH-a). Am J Reprod Immunol 33:134-139. 93. Yang YS, Ho HN, Chen HF, Chen SU, Shen CY, Chang SF, Huang ES, Wu CW (1995): Cytomegalovirus infection and viral shedding in the genital tract of infertile couples. J Med Virol 45:179-182. 94. Yang YS, Wu MY, Chen SU, Ho HN, Chen HF, Chao KH, Huang SC, Lee TY (1995): Tests of human sperm function and fertilization in vitro. Assist Reprod Technol Androl 7:214-222. 95. Ho HN, Chen HF, Chen SU, Chao KH, Yang YS, Huang SC, Lee TY, Gill TJ III (1995): Gonadotropin-releasing hormone (GnRH) agonist induces suppression of CD 25+ CD3+ lymphocyte subpopulations in peripheral blood. Am J Reprod Immunol 33:243-252. 96. Lee TTY, Ho HN, Yang YS, Chen HF (1995): Tumor necrosis factor- and interleukin 1 levels in the follicular fluids of patients with premature luteinization. In: Fujimoto S, Hsueh AJW, Strauss JFIII and Tanaka T eds. New Achievements in Research of Ovarian Function. Ares Serono Symposia, pp199-208. 97. Chen SU, Ho HN, Chen HF, Chao KH, Huang SC, Lee TY, Yang YS (1995): The effect of assisted hatching by partial zona dissection on ICR mouse embryos in vitro. J Formosan Med Assoc 94:463-468. 98. Wu MY, Chen HF, Chen SU, Chao KH, Yang YS, Huang SC, Lee TY, Ho HN (1995): Heterotopic pregnancies after controlled ovarian hyperstimulation and assisted reproductive techniques. J Formosan Med Assoc 94:600-604. 99. Chen SU, Ho HN, Chao KH, Chen HF, Chen CA, Yang YS (1995): Successful treatment of a combined interstitial and intrauterine pregnancy after tubal embryo transfer (TET). Acta Obstet Gynecol Scand 74:752-755. 100. Chen SU, Ho HN, Chen HF, Chao KH, Lin HR, Huang SC, Lee TY, Yang YS (1995): 9 Yu-Shih Yang 2014 Comparison between two-layer discontinuous percoll gradient and swim-up for sperm preparation on normal and abnormal semen samples. J Assist Reprod Genet 12:698-703. 101. Ho HN, Chao KH, Chen HF, Wu MY, Yang YS, Lee TY (1995): Peritoneal natural killer cytotoxicity and CD25+ CD3+ lymphocyte subpopulation are decreased in women with stage III-IV endometriosis. Hum Reprod 10:2671-2675. 102. Chao KH, Ho HN, Yang YS, Chen SU, Chen HF, Dai HJ, Huang SC, Gill TJ III (1995): Decidual natural Killer cytotoxicity decreased in normal pregnancy but not in anembryonic pregnancy and recurrent spontaneous abortion. Am J Reprod Immunol 34:274-280. 103. Chen HF, Ho HN, Chen SU, Chao KH, Lin HR, Huang SC, Lee TY, Yang YS (1995): Interleukinluteinization. Am J Reprod Immunol 34:356-362. 104. Tsai YL, Lin YH, Hwang JL, Yang YS, Lee TY (1995): Acrosome reaction induced by 24-hour exposure to human follicular fluid. J Repord Infertil 4:15-19. 105. Torng BL, Chang DY, Chen CK, Lee LC, Yang YS, Hung HF, Liu CC, Huang SC (1995): Geriatric gynecological surgery at National Taiwan University Hospital during the period 1984-1993. J Obstet Gynecol ROC 34:197-201. 106. Lee LC, Chao KH, Chen SU, Chen HF, Ho HN, Huang SC, Yang YS (1995): Inadvertent exposure of gonadotropin-releasing hormone agonist during an early human pregnancy. J Reprod Infertil 4:113-119. 107. Chuang CC, Chen HF, Chen SU, Chao KH, Wu MY, Chen CD, Ho HN, Lee TY, Yang YS (1995): Arterial velocity waveform study in the prediction of response of a gonado-tropin-releasing hormone analogue (zoladex) in the treatment of uterine fibroids. J Reprod Infertil 4:125-132. 108. Lin HR, Shen CC, Chang LJ, Lin JR, Hung SH, Chen HF, Chen SU, Lien YR, Ho HN, Yang YS (1995): Rescue effect of ethylenediamine tetraacetic acid (EDTA) on in vitro development of mouse embryos superovulated by gonadotropins. J Reprod Infertil 4:138-141. 109. Hwang JL, Wu CC, Ho HN, Tsai YL, Yang YS, Huang SC, Lee TY(1996): Laparoscopic assisted vaginal hysterectomy - when should it be an alternative to abdominal hysterectomy. J Reprod Infertil 5:5-11. 110. Tseng LH, Lee TY, Yang YS, Ko TM, Chuang SM (1996):Norplant subdermal contraceptive system: experience in Taiwan. Contraception 53:177-180. 111. Wu MY, Yang YS, Huang SC, Ho HN (1996): Prolongation of pregnancy and survival of both twins after preterm premature rupture of membrance of twin A at 19 weeks’ gestation. Acta Obstet Gynecol Scand 75:299-302. 112. Wu MY, Chao KH, Chen SU, Chen HF, Yang YS, Huang SC, Ho HN (1996): The suppression of peritoneal cellular immunity in women with endometriosis could be restored after gonadotropin releasing hormone agonist treatment. Am J Reprod Immunol 35:510-516. 113. Chen CD, Wu MY, Ho HN, Huang SC, Yang YS, Cheng JR (1996): Congenital atresia of the uterine cervix and vagina: report of a case. Acta Obstet Gynecol Scand 75:770-771. 114. Wu MY, Chen SU, Chen HF, Chao KH, Chen CD, Ho HN, Huang SC, Lee TY, Yang YS (1996): How many embryos should be transferred in an in vitro fertilization and embryo transfer program? J Formosan Med Assoc 95:617-622. 115. Chen SU, Ho HN, Chen HF, Tsai TC, Lee TY, Yang YS (1996): Fertilization and embryo 10 Yu-Shih Yang 2014 cleavage after intracytoplasmic spermatid injection in an obstructive azoospermic patients with defective spermiogenesis. Fertil Steril 66:157-160. 116. Wu MY, Yang YS, Huang SC, Lee TY, Ho HN (1996): Emergent and elective cervical cerclage for cervical incompetency. Int J Gynecol Obstet 54:23-29. 117. Sheu BC, Ho HN, Yang YS (1996): Spontaneous pregnancy after previous pregnancy by oocyte donation due to premature ovarian failure. Hum Reprod 11:1359-1360. 118. Ou MC, Yang YS (1996): The implication of sperm head agglutination induced by a V3 peptide (fragment 307-330, HIV-1 envelope protein gp120) solution. Arch Androl 37:65-70. 119. Ho HN, Chao KH, Chen CK, Yang YS, Huang SC (1996): The activation status of T and NK cells in the endometrium throughout menstrual cycle, normal and abnormal early pregnancy. Hum Immunol 49:130-136. 120. Chen SU, Ho HN, Chen HF, Chao KH, Wu MY, Chen CD, Huang SC, Lee TY, Yang YS (1996): Combination of direct swim-up technique and discontinuous percoll gradient centrifugation for sperm preparation of oligoasthenozoospermic samples. Arch Androl 37:103-109. 121. Ho HN, Wu MY, Chao KH, Chen CD, Chen SU, Chen HF, Yang YS (1996): Decrease in interferon gamma production and impairement of T-lymphocyte proliferation in peritoneal fluid of women with endometriosis. Am J Obstet Gynecol 1996; 175:1236-1241. 122. Wu MY, Chen HF, Ho HN, Chen SU, Choa KH, Huang SC, Lee TY, Yang YS (1996): The Value of human growth hormone as an adjuvant for ovarian stimulation in a human in vitro fertilization program. J Obstet Gynecol Res.22:443-450. 123. Chang HC, Wu MY, Ho HN, Yang YS (1996): Delayed delivery of surviving triplet after fetal reduction and spontaneous abortion. J Formos Med Assoc 95:881-884. 124. Chen SU, Ho HN, Chen HF, Huang SC, Lee TY, Yang YS (1996): Intracytoplasmic sperm injection (ICSI) for severe semen abnormalities: dissecting the tail of spermatozoa at the tip. Hum Reprod 11:2640-2644. 125. Chen SU, Ho HN, Chen HF, Huang SC, Lee TY, Yang YS (1996): Pregnancy achieved by intracytoplasmic sperm injection using cryopreserved semen from a man with testicular cancer. Hum Reprod 11:2645-2647. 126. Chen CD, Wu MY, Chao KH, Chen HF, Chen SU, Ho HN, Huang SC, Yang YS (1997): Effects of peritoneal fluid on patterns of sperm motility in women with endometriosis. Arch Androl 38:49-55. 127. Chen SU, Ho HN, Chao KH, Wu MY, Chen CD, Chang HC, Yang YS (1997): Treatment of severe male-factor infertility using intracytoplasmic sperm injection (ICSI). Formaosan J Med 1:12-22. 128. Chen CD, Ho HN, Yang YS (1997): Tubal embryo transfer improves pregnancy rate. Hum Reprod 12:629-630. 129. Chen SU, Ho HN, Chen HF, Chao KH, Huang SC, Lee TY, Yang YS (1997): A simplified technique for embryo biopsy: use of the same micropipette for zona drilling and blastomere aspiration. J Assist Reprod Genet 14: 157-161. 130. Chao KH, Chen SU, Chen HF, Wu MY, Yang YS, Ho HN (1997): Assisted hatching increase the implantation and pregnancy rate of in vitro fertilization-embryo transfer, but not that of tubal embryo transfer in patients with repeated IVF failures. Fertil Steril 67:904-908. 131. Chen CD, Wu MY, Yang JH, Chen SU, Ho HN, Yang YS (1997): Intravenous albumin does not 11 Yu-Shih Yang 2014 prevent the development of severe ovarian hyperstimulation syndrome. Fertil Steril 68:287-291. 132. Chen CD, Ho HN, Wu MY, Chao KH, Chen SU, Yang YS (1997): Paired human chorionic gonadotropin determinations for the prediction of pregnancy outcome in assisted reproduction. Hum Reprod 12:2538-2541. 133. Ho HN, Wu MY, Chao KH, Chen CD, Chen SU, Yang YS (1997): Peritoneal interleukin-10 increases with decrease in activated CD4+ T lymphocytes in women with endometrioses. Hum Reprod 12:2528-2533. 134. Chen CD, Wu MY, Chao KH, ChenSU, Ho HN, Yang YS (1997): Serum estradiol level and oocyte number in predicting severe ovarian hyperstimulation syndrome. J Formos Med Assoc 96:829-834. 135. KO TM, Yang YS, Wu MY, Kao CH, Hsu PM, Chuang SM, Lee TY (1997): Complete androgen insensitivity syndrome: molecular characterization in two Chinese women. J Reprod Med 42:424-428. 136. Yang JH, Wu MY, Chao KH, Chen SU, Ho HN, Yang YS (1997): Long GnRH-agonist protocol in an IVF program: is it appropriate for women with normal FSH levels and high FSH/LH ratios? J Reprod Med 42:663-668. 137. Ho HN, Wu MY, Yang YS (1997): Peritoneal cellular immunity and endometriosis. Am J Reprod Immunol 38:400-412. 138. Yang JH, Chen SU, Chao KH, Wu MY, Chen CD, Ho HN, Yang YS (1997): Day 3 embryo transfer achieved similar reproductive outcome when compared with day 2 embryo transfer. Taiwanese J Obstet Gynecol 36:111-116. 139. Ho HN, Wu MY,Chen SU, Chao KH, Chen CD, Yang YS(1997): Total antioxidant status and nitric oxide do not increase in peritoneal fluids from women with endometriosis. Hum Reprod 12:2810-2815. 140. Chen SU, Shieh JY, Wang YH, Chang HC, HO HN, Yang YS (1998): Pregnancy achieved by intracytoplasmic sperm injection using cryopreserved vasal-epididymal sperm from a man with spinal cord injury. Arch Phys Med Rehabil 79:218-221. 141. Yang JH, Chao KH, Wu MY, Chen CD, Chen HF, Chen SU, HO HN, Yang YS (1998): Premature luteinization during ovarian stimulation did not affect pregnancy outcome in in vitro fertilization cycles. Formosan J Med 2:1-7. 142. Chen CD, Yang YS, Ho HN (1998): Does IV albumin prevent severe ovarian hyperstimulation? Fertil Steril 69: 356-357. 143. Chen SU, Chao KH, Wu MY, Chen CD, Ho HN, Yang YS (1998): The simplified two-pipette technique is more efficient than the conventional three-pipette method for blastomere biopsy in human embryos. Fertil Steril 69:569-575. 144. Chen CD, Chen SU, Chao KH, Wu MY, Ho HN, Yang YS (1998) Cornual pregnancy after IVF-ET: a report of three cases. J Reprod Med 43:393-396. 145. Yang JH, Wu MY, Chen CD, Chao KH, Chen SU, Ho HN, Yang YS (1998) Spermatozoa recovered by IxaPrep gradient have improved longevity and better motion characteristics than those by percoll gradient. Arch Androl 40:237-245. 146. Chen CD, Yang JH, Chao KH, Chen SU, Ho HN, Yang YS (1998): Effects of repeated abdominal paracentesis on uterine and intraovarian hemodynamics and pregnancy outcome in severe ovarian hyperstimulation syndrome. Hum Reprod 13: 2077-2081. 12 Yu-Shih Yang 2014 147. Yang JH, Wu MY, Chao KH, Chen SU, Ho HN, Yang YS (1998): Controlled ovarian hyperstimulation and intrauterine insemination in subfertility. J Reprod Med 43: 903-908. 148. Jiang MC, Chen SU, Wu MY, Chen CD, HoHN, Yang YS (1998): Term delivery after second day intracytoplasmic sperm injection and laparoscopic tubal embryo transfer - a case report. J Reprod Infertil 7: 73-76. 149. Wu MY, Ho HN, Chen SU, Chao KH, Chen CD, Yang YS (1999): Increase in the production of interleukin-6, interleukin-10, and interleukin-12 by lipopolysaccharide-stimulated peritoneal macrophages from women with endometriosis. Am J Reprod Immunol 41: 106-111. 150. Chang HC, Hsieh JT, Liu SP, Law HS, Chen SU, Yang YS (1999): Fertilization capability of frozen epididymal sperm for intracytoplasmic sperm injection. J Formos Med Assoc 98: 171-174. 151. Jiang MC, Lien YR, Chen SU, Ko TM, Ho HN, Yang YS (1999): Transmission of de novo mutations of the deleted in azoospermia genes from a severely oligozoospermic male to a son via intracytoplasmic sperm injection. Fertil Steril 71:1029-1032. 152. Yang JH, Wu MY, Chen CD, Jiang MC, Ho HN, Yang YS (1999): Association of endometrial blood flow as determined by a modified colour Doppler technique with subsequent outcome of in-vitro fertilization. Hum Reprod 14:1606-1610. 153. Chen CD, Wu MY, Chen HF, Chen SU, Ho HN, Yang YS (1999): Prognostic importance of serial cytokine changes in ascites and pleural effusion in women with severe ovarian hyperstimulation syndrome. Fertil Steril 72:286-292. 154. Chen HF, Shew JY, Ho HN, Hsu WL, Yang YS (1999): Expression of leukemia inhibitory factor and its receptor in preimplantation embryos. Fertil Steril 72:713-719. 155. Chao KH, Yang JH, Chen CD, Yang JH, Yang YS (1999): The expression of killer cell inhibitory receptors on natural killer cells and activation status of CD4+ and CD8+ T cell in the decidua of normal and abnormal early pregnancies. Hum Immunol 60:791-797. 156. Chao KH, Yang JH, Chen CD, Wu MY, Ho HN, Yang YS (1999): Clinical assessment of women undergoing in vitro fertilization and tubal embryo transfer using recombinant human follicle-stimulation hormone. Taiwanese J Obstet Gynecol 38:121-130. 157. Wu MY, Ho HN, Chao KH, Chen CD, Yang YS, Lee TY (1999): Clinical performance of the levonorgestrel intrauterine contraceptive device (Mirena®) and its effect on menorrhagia in Taiwanese women. Taiwanese J Obstet Gynecol 38:131-140. 158. Tsai YY, Yang JH, Wu MY, Lu HF, Ho HN, Yang YS (1999): Assisted hatching achieved with the use of pronase in a mouse model at various embryo stages. Taiwanese J Obstet Gynecol 38:141-146. 159. Huang SC, Sheu BC, Torng PL, Tsai CW, Chen RJ. Yang YS, Shyu RS, Tsai HD, Yeh GP (1999): Prevalence of gestational trophoblastic disease in Taiwan. Trophoblast Research 13:171-177. 160. Chen CD, Wu MY, Chen HF, Chen SU, Ho HN, Yang YS (2000): Relationships of serum pro-inflammatory cytokines and vascular endothelial growth factor with liner dysfunction in severe ovarian hyperstimulation syndrome. Hum Reprod 15:66-71. 161. Chen HF, Shew JY, Chao KH, Chang LJ, Ho HN, Yang YS (2000): Luteinizing hormone up-regulates the expression of interleukin-1β mRNA in human granulosa-luteal cells. Am J Reprod Immunol 43:125-133. 13 Yu-Shih Yang 2014 162. Chen CD, Chen HF, Lu HF, Chen SU, Ho HN, Yang YS (2000): Value of serum and follicular fluid cytokine profile in the prediction of moderate to severe ovarian hyperstimulation syndrome. Hum Reprod 15:1037-1042. 163. Chen SU, Chen HF, Lien YR, Ho HN, Chang HC, Yang YS (2000): Schedule to inject in vitro mature oocytes may increase pregnancy after intracytoplasmic sperm injection. Arch Androl 44:197-205. 164. Yang JH, Chen CD, Wu MY, Chao KH, Yang YS, Ho HN (2000): Hormone replacement therapy reverses the decrease in natural killer cytotoxicity but does not reverse the decreases in the T-cell subpopulation or interferon-gamma production in postmenopausal women. Fertil Steril 74:261-267. 165. Chen SU, Lien YR, Chao KH, Lu HF, Ho HN, Yang YS (2000): Cryopreservation of mature human oocytes by vitrification with ethylene glycol in straws. Fertil Steril 74:804-808. 166. Wu MY, Yang JH, Chao KH, Hwang JL, Yang YS, Ho HN (2000): Increase in the expression of killer cell inhibitory receptors on peritoneal natural killer cells in women with endometriosis. Fertil Steril 74:1187-1191. 167. Chen SU, Lein YR, Chen HF, Chao KH, Ho HN, Yang YS (2000): Open pulled straws for vitrification of mature mouse oocytes preserve patterns of meiotic spindles and chromosomes better than conventional straws. Hum Reprod 15:2598-2603. 168. Chen SU, Lein YR, Ho HN, Yang YS (2000): Intracytoplasmic sperm injection. J Reprod Infertil 9:1-8. 169. Wu MY, Ho HN, Chen SU, Chao KH, Chen CD, Yang YS (2000): Decreased levels of transforming growth factorObstet Gynecol 39:99-103. 170. Wu MY, Chen SU, Chao KH, Chen CD, Yang YS, Ho HN (2001): Mouse embryo toxicity of IL-6 in peritoneal fluids from women with or without endometriosis. Acta Obstet Gynecol Scand 80:7-11. 171. Chen M, Chen CD, Yang YS (2001): Torsion of the previously normal uterine adnexa. Acta Obstet Gynecol Scand 80: 58-61. 172. Su TJ, Chen YC, Yang YS (2001): Somatic symptoms during in vitro fertilization treatment. Formosan J Med 5:144-152. 173. Su TJ, Chen YC, Hung YT, Yang YS (2001): Comparative study of daily activities of pregnant and non-pregnant women after in vitro fertilization and embryo transfer. J Formos Med Assoc 100:262-268. 174. Yang JH, Chen HF, Lien YR, Chen SU, Ho HN, Yang YS (2001): Elevated E2: oocyte ratio in women undergoing IVF and tubal ET. J Reprod Med 46:434-438. 175. Chen SU, Lien YR, Yang YS (2001): Source of vitrification solution. Fertil Steril 76:215 (letters to the editor). 176. Chen SU, Ho HN, Yang YS (2001): Vitrification of embryos and oocytes with 5.5 mol/L ethylene glycol and 1.0 mol/L sucrose. Hum Reprod 16:1778-1779 (letters to the editor). 177. Chen SU, Ko TM, Hwa HL, Lu PJ, Ho HN, Yang YS (2001):Maternal serum c-reactive protein level does not change significantly after fetal reduction: it could be used as an indicator of chorioamnionitis. J Assist Reprod Genet 18:336-340. 14 Yu-Shih Yang 2014 178. Wu MY, Yang YS, Ho HN (2001):Impaired natural killer cell activity in endometriosis? A technical challenge for validation. Fertil Steril 76:422-423 (letter to the editor). 179. Lin KC, Chen HF, Huang PT, Wu MY, Ho HN, Yang YS (2001): effectiveness of post operative adjuvant therapy in improving reproductive outcome of endometriosis-associated infertility. J Formos Med Assoc 100:466-470. 180. Ho HN, Chao KH, Chen HF, Chen SU, Wu MY, Yang YS (2001): Distribution of Th 1 and Th 2 Cell populations in human peripheral and decidual T cell from normal and anembryonic pregnancies. Fertil Steril 76:797-803. 181. Chen SU, Lien YR, Cheng YY, Chen HF, Ho HN, Yang YS (2001): Vitrification of mouse oocytes using closed pulled straws (CPC) achieves a high survival and preserves good patterns of meiotic spindles, compared with conventional straws, open pulled straws (OPS) and grids. Hum Reprod 16:2350-2356. 182. Wu MY, Chen HF, Chen SU, Chao KH, Yang YS, Ho HN (2001): Increase in the production of interleukin-10 early after implantation is related to the success of pregnancy. Am J Reprod Immunol 46:386-392. 183. Chen CD, Yang JH, Lin KC, Chao KH, Ho HN, Yang YS (2002): The significance of cytokines, chemical composition, and murine embryo development in hydrosalpinx fluid for predicting the IVF outcome in women with hydrosalpinx. Hum Reprod 17:128-133. 184. Chou HC, Tsao PN, Yang YS, Tang JR, Tsou KI (2002): Neonatal outcome of infants born after in vitro fertilization at National Taiwan University Hospital. J Formos Med Assoc 101:203-205. 185. Chen SU, Lien YR, Tsai YY, Chang LJ, Ho HN, Yang YS (2002): Successful pregnancy occurred from slowly freezing human oocytes using the regime of 1.5 mol/l 1,2-propanediol with 0.3 mol/l sucrose. Hum Reprod. 17:1412. 186. Chen HF, Lin CY, Chao KH, Wu MY, Yang YS, Ho HN (2002): Defective production of interleukin-11 by decidua and chorionic villi in human anembryonic pregnancy. J Clin Endocrinol Metab 87:2320-2328. 187. Chao KH, Wu MY, Yang JH, Chen SU, Yang YS, Ho HN (2002): Expression of the interleukin-2 receptor (CD25) is selectively decreased on dicidual CD4+ and CD8+ T lymphocytes in normal pregnancies. Mol Hum Reprod 8:667-673. 188. Yang JH, Chao KH, Wu MY, Chen SU, Ho HN, Yang YS (2002): One-step hysteroscopic resection of submucous uterine myomas. Taiwanese J Obstet Gynecol 41:99-104. 189. Chen MJ, Ho HN, Yang YS (2002):Thyroid disease and female reproduction. Formosan Journal of Medicine Vol.5, No.5, pp 597-599 190. Chuang CC, Chen CD, Chao KH, Chen SU, Ho HN, Yang YS (2003): Age is a better predictor of pregnancy potential than basal follicle-stimulating hormone levels in women undergoing in vitro fertilization. Fertil Steril 79:63-68. 191. Chen SU, Lien YL, Chao KH, Ho HN, Yang YS, Lee TY (2003) :Effects of cryopreservation on meiotic spindles of oocytes and its dynamics after thawing: clinical implications in oocyte freezing- a review article. Mol Cell Endocrinol 202: 101-107. 192. Huang PT., Chen SU., Chao KH., Chen CD., Ho HN., Yang YS (2003): Comparison of the effects of fertilization-promoting peptide, adenosine, and pentoxifylline on thawed human spermatozoa. Arch Androl 49:145- 153. 15 Yu-Shih Yang 2014 193. Shieh JY., Chen SU., Wang YH., Chang HC., Ho HN., Yang YS (2003): A protocol of electroejaculation and systematic assisted reproductive techonology achieved high efficiency and efficacy for pregnancy for aenjeculatory men with spinal cord injury. Arch Phys Med Rehabil 2003; 84: 535- 540. 194. Yang YS (2003): Does it all come down to postnatal aging of the primary oocyte? Fertil Steril 79:1471(letters to the editor). 195. Chen CD, Chao KH, Yang JH, Chen SU, Ho HN, Yang YS (2003): Comparison of coasting and intravenous albumin in the prevention of ovarian hyperstimulation syndrome. Fertil Steril 80: 86-90. 196. Wu MY, Chao KH, Yang JH, Lee TY, Yang YS, Ho HN(2003):Nitric oxide synthesis is increased in the endometrial tissue of women with endometriosis. Hum Reprod 18:2668-2671. 197. Chen SU, Lien YR, Ko TM, Ho HN, Yang YS, Chang HC(2003): Genetic Screening of Karyotypes and azoospermic factors for infertile men who are candidates for ICSI. Arch Androl 49:423-427. 198. Chen MJ, Yang JH, Yang YS (2003): Clinical Application and Complications of Hysteroscopy. Formosan Journal of Medicine Vol.7, No.3, pp 464-467 199. Chen MJ, Yang JH, Lin MC, HoHN, Yang YS, (2004): An unusual gestational choriocarcinoma occurring primarily on the surface of a subserous leiomyoma. Brit J Obstet Gynecol 111:188-190. 200. Chen SU, Chao KH, Chang CY, Hsieh FJ, HoHN, Yang YS (2004): Technical aspects of the Piezo laser-assisted, and conventional methods for nuclear transfer of mouse oocytes and their efficiency and efficacy: piezo minimizes damage of the ooplasmic membrane at injection. J.Exp Zool 301A:344-351. 201. Chen SU, Chang CY, Lu CC, Hsieh FJ, HoHN, Yang YS (2004): Microtubular spindle dynamics and chromosome complements from somatic cell nuclei haploidization in mature mouse oocytes and developmental potential of the derived embryos. Hum Reprod 19:1181-1188. 202. Lee TH, Wu MY, Chen MJ, Chao KH, Ho HN, Yang YS (2004): Nitric oxide is associated with poor embryo quality and pregnancy outcome in vitro fertilization cycles. Fertil Steril. 82:126-131. 203. Chen HF, Chao KH, Shew JY, Yang YS, Ho HN(2004): Expression of leukemia inhibitory factor and its receptor is not altered in the decidua and chorionic villi of human anembryonic pregnancy. Hum Reprod. 19:1647-1654. 204. Chen MJ, Yang JH, Yang YS, Ho HN(2004): Increased occurrence of tubo-ovarian abscesses in women with stage III and IV endometriosis. Fertil Steril. 82:498-499. 205. Yang JH, Chen MJ, Chen HF, Lee TH, Ho HN, Yang YS (2004): Decreased expression of killer cell inhibitory receptors on natural killer cells in eutopic endometrium in women with adenomyosis. Hum Reprod. 19:1974-1978. 206. Chen SU, Lien YL, Tsai YY, Chang LJ, Ho HN, Yang YS (2004) : Cryopreserved sibling oocytes and intracytoplasmic sperm injection rescue unexpectedly poor fertilization in conventional in vitro fertilization. J Assist Reprod Genet 21:364-366. 207. Huang CC, Lee TH, Chen SU, Chen HH, Cheng TC, Liu CH, Yang YS, Lee MS (2005):Successful pregnancy following blastocyst cryopreservation using super-cooling ultra-rapid vitrification. Hum Reprod 20:122-128. 16 Yu-Shih Yang 2014 208. Chen MJ, Wu MY, Yang JH, Chao KH, Yang YS, Ho HN (2005): Increased frequency of genital human papillomavirus infection in human immuno-deficiency virus-seropositive Taiwanese women. J Formos Med Assoc 104: 34-38. 209. Fu CF, Lee TH, Chen CD, Chen MJ, Ho HN, Yang YS (2005): Unexpected pregnancy and ovarian hyperstimulation syndrome following IVF cycle with all embryos frozen : a case report. Taiwan J Obstet Gynecol 44:83-86 210. Lee TH, WuMY, Chen HF, Chen MJ, Ho HN, Yang YS (2005): Ovarian response and follicular development for single-dose and multiple-dose protocols for gonadotropin-releasing hormone antagonist administration. Fertil Steril 83: 1700-1707 211. Chen MJ, Mao TL, Ho HN, Yang YS (2005) : Successful pregnancy in a gonadectomized women with 46, XY gonadal dysgenesis and gonadoblastoma. Fertil Steril 84:217 e5-6 212. Chen SU, Lien YL, Chen HF, Tsai YY, Chang LJ, Ho HN, Yang YS (2005): Observational clinical follow-up of oocyte cryopreservation using a slow-freezing method with 1, 2-propanediol plus sucrose followed by ICSI. Hum Reprod 20:1975-1980 213. Lu HF, Chang DU, Chen MJ, Chen SU, Ho HN, Yang YS (2005): Internal Herniation through the defect in broad ligament of uterus – a case report. Taiwan J Obstet Gynecol 44:273-275 214. Massimo Candiani, Herve Fernandez, Hiroshi Hoshiai, David L. Olive, Karl-Werner Schweppe, Yang YS (2005): Advisory Panel Discussion. Drugs of Today 41:29-54 215. Chen SU, Lee TH, Lien YR, Tsai YY, Chang LJ, Yang YS (2005): Microsuction of blastocoelic fluid before vitrification increased survival and pregnancy of mouse expanded blastocysts, but pretreatment with the cytoskeletal stabilizer did not increase blastocyst survival. Fertil Steril 84(Suppl 2):1156-1162 216. Ho CH, Peng FS, Chen HF, Lien YR, Chen SU, Yang YS (2005): Twin pregnancies conceived by assisted reproductive technology: maternal and perinatal outcomes. Taiwan J Obstet Gynecol 44:332-337 217. Chen MJ, Peng Y, Yang YS, Huang SC, Chow SN, Chow SN, Torng PL (2005): Increased hyaluronan and CD44 expression in intravenous leiomyomatosis. Acta Obstet gynecol Scand 84:322-328 218. Chen SU, Shieh JY, Wang YH, Lu T, Ho HN, Yang YS (2005): Successful pregnancy achieved by intracytoplasmic sperm injection using cryopreserved electroejaculate sperm for a couple both with spinal cord injury : a case report. Arch Phys Med Rehabil 86:1884-1886 219. Yang JH, Wu MY, Chang DY, Chang CH, Yang YS, Ho HN (2006): Increased interleukin-6 messenger RNA expression in macrophage-cocultured endometrial stromal cells in adenomyosis. Am J Reprod Immunol 55:181-187 220. Su TJ, Chen HF, Chen YC, Yang YS, Hung YT (2006): Factors related to meaning of life in Taiwanese women treated with in vitro fertilization. J Formos Med Assoc 105:404-413 221. Lee TH, Chen CD, Tsai YY, Chang LJ, Ho HN, Yang YS (2006): Embryo quality is more important for younger women whereas age is more important for older women with regard to in vitro fertilization outcome and multiple pregnancy. Fertil Steril 86:64-69 222. Chen SU, Chieu CL, Wu MY, Chen TH, Lai SM, Lin CW, Yang YS (2006): Novel direct cover vitrification for cryopreservation of ovarian tissues increases follicle viability and pregnancy capability in mice. Hum Reprod 21:2794-2800 17 Yu-Shih Yang 2014 223. Chen MJ, Yang WS, Yang JH, Hsiao CK, Yang YS, Ho HN(2006): Low sex hormone-binding globulin is associated with low high-density lipoprotein cholesterol and metabolic syndrome in women with PCOS. Hum Reprod 21: 2266- 2271. 224. Lee TH, Wu MY, Chen HF, Chen SU, Ho HN, Yang YS (2006): Association of a single dose of gonadotropin – releasing hormone antagonist with nitric oxide and embryo quality in in vitro fertilization cycles. Fertil Steril 86: 1020- 1022. 225. Chen MJ, Yang JH, Peng FH, Chen SU, Ho HN, Yang YS (2006): Extended estrogen administration for women with thin endometrium in frozen-thawed in vitro fertilization programs. J Assist Reprod Genet 23: 337- 342. 226. Yang JH, Ho HN, Yang YS (2006): Current diagnostic and treatment stategies for adenomyosis. Expert Rev Obstet Gynecol 1:111-120 227. Yang JH., Chen MJ., Wu MY., Chen YC., Yang YS., Ho HN (2006): Decreased suppression of interleukin-6 after treatment with medroxyprogesterone acetate and danazol in endometrial stromal cells of women with adenomyosis. Fertil Steril 86: 1459- 1465 228. Chen HF, Kuo HC, Chien CL, Shun CT, Yao YL, Ip PL, Yang YS, Ho HN (2007) :Derivation, characterization and differentiation of human embryonic stem cells: comparing serum-containing versus serum-free media and evidences of germ cell differentiation. Hum Reprod 22:567-577 229. Yang JH., Wu MY., Chen CD., Kuo YC., Yang YS., Ho H-N (2007): Altered apoptosis and proliferation in endometrial stromal cells of women with adenomyosis. Hum Reprod 22:945-952 230. Chao KH., Wu MY., Yang JH., Chen SU., Yang YS., Ho HN (2007): Decreased expression of CD25 on decidual activated T lymphocytes is not mediated by reduced CD25 messenger ribonucleic acid. Fertil Steril 87:182-188 231. Chen MJ, Yang WS, Yang JH, Chen CL, Ho HN, Yang YS (2007): Relationship between androgen levels and blood pressure in young women with polycystic ovary syndrome. Hypertension 49:1442-1447 232. Chen MJ, Lin LY, Yang YS (2007): Response to polycystic ovary syndrome : androgens, autonomic nervous system and hypertension . Hypertension 50:e8 233. Chen MJ, Yang YS (2007): Response to polycystic ovary syndrome : implications of corticotrophin in the regulation of blood pressure, aldosterone, and androgen secretion. Hypertension 50:e25 234. Yang JH, Shih JC, Liu KL, Yang YS (2007): Combined treatment with temporary intraoperative balloon occlusion of common iliac arteries and hysteroscopic endocervical resection with post operative cervical balloon for intractable cervical pregnancy in an infertile woman. Fertil Steril 88:1438.e11-13. 235. Yang JH, Chen MJ, Wu MY, Chao KH, Ho HN, Yang YS (2008): Office hysteroscopic early lysis of multiple apposing submucons myomas. Fertil Steril 89:1254-1259. 236. Ho CH, Chen SU, Peng FS, Chang CY, Lien YR, Yang YS (2008): Prospective comparison of short and long GnRH agonist protocols using recombinant gonadotrophins for IVF/ICSI treatments. Reprod Biomed Online. 16:632-639. 237. Chen MJ, Yang WS, Chen CL, Wu MY, Yang YS, Ho HN (2008): The relationship between anti-Mullerian hormone, androgen and insulin resistance on the number of antral follicles in women with polycystic ovary syndrome. Hum Reprod.23:952-957. 18 Yu-Shih Yang 2014 238. Chen SU, Chou CH, Lee H, Ho CH, Lin CW, Yang YS (2008): Lysophosphatidic acid up-regulates expression of interleukin-8 and -6 in granulosa-lutein cells through its receptors and nuclear factor-kappaB dependent pathways: implications for angiogenesis of corpus luteum and ovarian hyperstimulation syndrome. J Clin Endocrinol Metab. 93:935-943. 239. Lee TH, Lin YH, Seow KM, Hwang JL, Tzeng CR, Yang YS (2008): Effectiveness of cetrorelix for the prevention of premature luteinizing hormone surge during controlled ovarian stimulation using letrozole and gonadotropins: a randomized trial. Fertil Steril. 90:113-120. 240. Lee TH, Liu CH, Huang CC, Wu YL, Shih YT, Ho HN, Yang YS, Lee MS (2008): Serum anti-Müllerian hormone and estradiol levels as predictors of ovarian hyperstimulation syndrome in assisted reproduction technology cycles. Hum Reprod. 23:160-167. 241. Chen SU, Su YN, Fang MY, Chang LJ, Tsai YY, Li-Ting Lin, Lee CN, Yang YS (2008): Preimplantation genetic diagnosis of β-thalassaemia and HLA haplotypes using the OmniPlex technology of whole genome amplification. Reprod BioMed Online 17:699-705. 242. Hsieh CS, Chen SU, Lee YW, Yang YS, Sun CK (2008): Higher harmonic generation microscopy of in vitro cultured mammal oocytes and embryos. Optics Express 16:11574-11588. 243. Chen SU, Lee HY, Chang DY, Chou CH, Chang CY, KH Chao, CW Lin, Yang YS (2008): Lysophosphatidic acid mediates interleukin-8 expression in human endometrial stromal cells through its receptor and nuclear factor-кB dependent pathway: a possible role in angiogenesis of endometrium and placenta. Endocrinology 149:5888-5896 244. Chen SU, Chen CD, Yang YS (2008): Ovarian hyperstimulation syndrome (OHSS): new strategies of prevention and treatment. J Formos Med Assoc 107:509-513. 245. Ho CH, Chen SU, Peng FS, Chang CY, Yang YS (2008): Luteal support for IVF/ICSI cycles with crinone 8% (90mg) twice daily results in higher pregnancy rates than with intramuscular progesterone. J Chin Med Assoc 71: 386-391 246. Chen SU, Yang YS (2009): Slow freezing or vitrification of oocytes: their effects on survival and meiotic spindles and the time schedule for clinical practice. Taiwan J Obstet Gynecol 48:15-22. 247. Chen HF, Kuo HC, Chen W, Wu FC, Yang YS, Ho HN(2009): Low oxygen tension (5%) is not beneficial for maintaining human embryonic stem cells in undifferentiated state in routine culture with short splitting intervals. Hum Reprod 24:71-80. 248. Yang JH, Wu MY, Chen MJ, Chen SU, Yang YS, Ho HN (2009): Increased matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-1 secretion but unaffected invasiveness of endometrial stromal cells in adenomyosis Fertil Steril; 91(Suppl):2193-2198 249. Chen MJ, Chen HF, Chen SU, Ho HN, Yang YS, Yang WS(2009): The relationship between follistatin and chronic low-grade inflammation in women with polycystic ovary syndrome. Fertil Steril 92:2041-2044 250. Chen SU, Chou CH, Lee HY, Wu JC, Lin CW, Lu HF, Chen CD, Yang YS (2010): Signal mechanisms of IL-8 and VEGF play major roles in ovarian hyperstimulation syndrome (OHSS) : Dopamine targets their common pathways. Hum Reprod 25:757-767 251. Chen SU, Chou CH, Chao KH, Lee HY, Lin CW, Lu HF, Yang YS (2010): Lysophosphatidic acid up-regulates expression of growth regulated oncogene-α (GRO-α), interleukin-8 (IL-8), and monocyte chemoattractant protein-1 (MCP-1) in human first trimester trophoblasts: possible roles in angiogenesis and immune regulation. Endocrinology 151:369-379. 19 Yu-Shih Yang 2014 252. Hung CC, Chen SU, Lin SY, Fang MY, Chang LJ, Tsai YY, Lee CN, Su YN, Yang YS (2010): Preimplantation genetic diagnosis of β-thalassaemia using real-time PCR with FRET hybridization probes. Anal Biochem 400 : 69-77. 253. Chen MJ, Yang WS, Chen HF, Kuo JJ, Ho HN, Yang YS, Chen SU(2010): Increased follistatin levels after oral contraceptive treatment in obese and non-obese women with polycystic ovary syndrome. Hum Reprod 25:779-785. 254. Lien YR, Lu HF, Peng FS, Chiu BC, Yeh SH, Yang YS(2010): Factors associated with failure to achieve birth emphasizing a successful singleton at term following in vitro fertilization. Int J Gynecol Obstet 110:57-60. 255. Peng FS, Wu MY, Yang JH, Chen SU, Ho HN, Yang YS(2010): Insertion of the Mirena intrauterine system for treatment of adenomyosis-associated menorrhagia : a novel method. Taiwan J Obstet Gynecol 49: 160-164. 256. Chen MJ, Chiu HM, Chen CL, Yang WS, Yang YS, Ho HN (2010) : Hyperandrogenemia is independently associated with elevated alanine aminotransferase activity in young women with polycystic ovary syndrome. J Clin Endocrinol Metab 95:3332-3341. 257. Chen SU, Chen RJ, Shieh JY, Chao CH, Lin CW, Lu HF, Yang YS(2010): Human chorionic gonadotropin up-regulates expression of myeloid cell : implication of corpus luteum rescue and ovarian hyperstimulation syndrome. J Clin Endocrinol Metab 95:3982-3992. 258. Wu MY, Chen SU, Lee CN, Ho HN, Yang YS (2010) : Use of Alosiban in a twin pregnancy with extremely preterm premature rupture of membrane of membrance of one twin: a case report and literature review. Taiwan J Obstet Gynecol 2010; 49: 495- 499. 259. The corifollitropin alfa Ensure study group (2010): Corifollitropin alfa for ovarian stimulation in IVF : a randomized trial in lower-body-weight women. Reprod Bio Med Online 21:66-76. 260. Lin CH, Lin SY, Yang YH, Shih JC, Shy MK, Lee CN, Yang YS(2010) : Extremely preterm cesarean delivery “ En Caul”. Taiwan J Obstet Gynecol 49:254-259. 261. Chen MJ, Chen CD, Yang JH, Chen CL, Ho HN, Yang WS, Yang YS(2011): High dehydroepiandrosterone sulfate is associated with a reduced risk of abdominal obesity independent of high testosterone in women with polycystic ovarian syndrome. Hum Reprod 26: 227- 234. 262. Yang JH, Chen MJ, Chen CD, Chen CL, Ho HN, Yang YS(2011): Impact of submucous myoma on the severity of anemia. Fertil Steril 95: 1769- 1772. 263. Chang HH, Chen MJ, Lu MY, Chern J, Lu CY, Yang YL, Jou ST, Lin DT, Yang YS, Lin KH (2011): Iron overload is associated with low anti-mullerian hormone in women with transfusion-dependent beta-thalassemia. Brit J Obstet Gynecol 118: 825-831. 264. Chen CD, Wu MY, Chao KH, Lien YR, Chen SU, Yang YS (2011) : Update on management of ovarian hyperstimulation syndrome. Taiwan J Obstet Gynecol 50:2-10. 265. Chen YL, Hung CC, Lin SY, Fang MY, Tsai YY, Chang LJ, Lee CN, Su YN, Chen SU, Yang YS, (2011) : Successful application of the strategy of blastocyst biopsy, vitrification, whole genome amplification, and thawed embryo transfer for preimplantation genetic diagnosis of neurofibromatosis type 1. Taiwan J Obstet Gynecol 50:74-78. 266. Wu MY, Chang LJ, Chen MJ, Chao KH, Yang YS, Ho HN (2011): Outcomes of assisted reproductive techniques for HIV-1-discordant couples using thawed washed sperm in Taiwan : comparison with control and testicular sperm extraction / microscopic epididymal sperm aspiration groups. J Formos Med Assoc 110:495-500. 20 Yu-Shih Yang 2014 267. Chang LJ, Chen SU, Tsai YY, Hung CC, Fang MY, Su YN, Yang YS (2011) : An update of preimplantation genetic diagnosis in gene diseases, chromosomal translocation, and aneuploidy screening. Clin Exp Reprod Med 38:1-8. 268. Wu MY, Chen SU, Yang YS (2011) : Using atosiban in uterine contractions of early pregnancies after assisted reproduction. J Formos Med Assoc 110:800 269. Yang YS, Ma GC, Shih JC, Chen CP, Chou CH, Yeh KT, Kuo SJ, Chen TH, Hwu WL, Lee TH, Chen M (2012) : Experimental treatment of bilateral fetal chylothorax using in utero pleurodesis. Ultrasound Obstet Gynecol 39:56-62 270. Chen CD, Chao KH, Wu MY, Chen SU, Ho HN, Yang YS (2012) : Ultrasound-guided hydrosalpinx aspiration during oocyte retrieval and a mouse embryo assay of hydrosalpinx fluid in a women with hydrosalpinx and hydrometra during in vitro fertilization treatment. Taiwan J Obstet Gynecol 51:106-108 271. Yeang CH, Ma GC, Shih JC, Yang YS, Chen CP, Chang CP, Wu SH, Kuo SJ, Chou HC, Hwu WL, Cameron AD, Ginsberg NA, Lin YS, Chen M (2012): Genome-wide gene expression analysis implicates the immune response and lymphangiogenesis in the pathogenesis of fetal chylothorax. PLos ONE 7:e34901 272. Lee TH, Lee MS, Liu CH, Tsao HM, Huang CC, Yang YS (2012): The association between microenvironmental reactive oxygen species and embryo development in assisted reproduction technology cycles. Reprod Sci 19:725-732 273. Chen CD, Chen SU, Yang YS (2012): Prevention and management of ovarian hyperstimulation syndrome. Best Pract Res Cl Ob 26:817-827 274. Huang CC, Lien YR, Chen HF, Chen MJ, Shieh CJ, Yao YL, Chang CH, Chen SU, Yang YS. (2012): The duration of pre-ovulatory serum progesterone elevation before hCG administration affects the outcome of IVF/ICSI cycles. Hum Reprod 27:2036-2045. 275. Chen MJ, Han DS, Yang JH, Yang YS, Ho HN, Yang WS. (2012): Myostatin and its association with abdominal obesity, androgen and follistatin levels in women with polycystic ovary syndrome. Hum Reprod 27:2476-2483. 276. Chang CY, Chen MJ, Yang WS, Yeh CY, Ho HN, Chen SU, Yang YS (2012). Hypoadiponectinemia: a useful marker of dyslipidemia in women with polycystic ovary syndrome. Taiwan J Obstet Gynecol 51:583-590. 277. Wei LH, Chou CH, Chen MW, Stefan RJ, Kuo ML, Chen SU, Yang YS (2013): The role of IL-6 trans-signaling in vascular leakage : implications for ovarian hyperstimulation syndrome in a murine model. J Clin Endocrinol Metab 98:E472-E484. 278. Chang LJ, Huang CC, Tsai YY, Hung CC, Fang MY, Lin YC, Su YN, Chen SU, Yang YS (2013). Blastocyst biopsy and vitrification are effective for preimplantation genetic diagnosis of monogenic diseases. Hum Reprod 28:1435-1444. 279. Yang JH, Chen MJ, Chen CD, Chen SU, Ho HN, Yang YS (2013). Optimal waiting period for subsequent fertility treatment after various hysteroscopic surgeries. Fertil Steril 99:2092-2096. 280. Lee TH, Lee MS, Huang CC, Tsao HM, Lin PM, Ho HN, Shew JY, Yang YS(2013). Nitric oxide modulates mitochondrial activity and apoptosis through protein S-nitrosylation for preimplantation embryo development. J Assist Reprod Genet 30:1063-1072. 281. Lee TH, Chen CD, Wu MY, Chen HF, Chen SU, Ho HN, Yang YS(2013). Blastocyst morphology score as an indicator of embryo competence for women aged younger than 38 years in in vitro fertilization cycles. Taiwan J Obstet Gynecol 52:374-380 21 Yu-Shih Yang 2014 282. Chen M, Yang YS, Shih JC, Lin WH, Lee DJ, Lin YS, Chou CH, Cameron AD, Ginsberg NA, Chen CA, Lee ML, Ma GC (2014). Microdeletions/duplications involving TBX1 gene in fetuses with conotruncal heart defects which are negative for 22q11.2 deletion on fluorescence in-situ hybridization. Ultrasound Obstet Ggynecol 43:396-403 283. Chen SU, Chou CH, Chen MJ, Chen TH, Yang YS, Yang JH (2014). Apoptotic effects of high estradiol concentrations on endometrial glandular cells. J Clin Endocrinol Metab 99:E971-E980. 284. Wu MY, Chao KH, Chen CD, Chang LJ, Chen SU, Yang YS (2014). Current status of comprehensive chromosome screening for elective single-embryo transfer. Obstet Gynecol Int (in press). 285. Yang JH, Chen MJ, Shih JC, Chen CD, Chen SU, Yang YS (2014). Light-guided hysteroscopic resection of complete septate uterus with preservation of duplicated cervix. J Minim Invasive Gynecol (in press) 22