Ben-Wen Li CV - Page 1
CURRICULUM VITAE - BEN WEN LI, M.D., Ph.D.
Date: July 22, 2005
Home Address:
36 Graeser
Acres
St. Louis, MO
63146
Tel: (314) 9940385
Office Address:
Infectious
Diseases Division
Washington
University School of
Medicine
660 S. Euclid
Avenue, Campus Box
8051
St. Louis, MO
63110
Tel: (314) 4547972, Fax: (314) 4545293
E-mail:
bli@im.wustl.edu
Education
Undergraduate
1970-1974 Medical
doctor, Faculty
of Medicine,
Hunan Medical
University,
Ben-Wen Li CV - Page 2
Changsha,
P.R.C.
Graduate school and
training
1974-1975 Fellow,
Department of
Parasitology and
Immunology,
Zhongshan
University, Kuanzhou
1980-1983 Master
degree in Medical
Parasitology and
infectious diseases,
Hunan Medical
University, Changsha,
P.R.C.
1983-1984 Fellow,
Immunology
Reference Laboratory
for World Health
Organization,
University of Geneva,
Switzerland.
1984-1989 Ph.D.,
Molecular Biology
and Genetics,
Hunan Medical
University, Changsha,
P.R.C.
Academic
Positions/Employm
ent
1975-1980
R
e
s
e
a
r
Ben-Wen Li CV - Page 3
c
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Ben-Wen Li CV - Page 4
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Ben-Wen Li CV - Page 5
i
t
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,
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a
,
P
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.
1983-1985
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o
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Ben-Wen Li CV - Page 6
a
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r
,
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a
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Ben-Wen Li CV - Page 7
d
I
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,
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u
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y
,
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a
Ben-Wen Li CV - Page 8
n
g
s
h
a
,
P
.
R
.
C
.
1985-1989
A
s
s
i
s
t
a
n
t
P
r
o
f
e
s
s
o
r
,
D
e
p
a
r
t
m
e
Ben-Wen Li CV - Page 9
n
t
o
f
P
a
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a
s
i
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o
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y
a
n
d
I
m
m
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o
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y
,
H
u
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a
n
M
e
Ben-Wen Li CV - Page 10
d
i
c
a
l
U
n
i
v
e
r
s
i
t
y
,
C
h
a
n
g
s
h
a
,
P
.
R
.
C
.
1989-1992
P
o
s
t
d
o
c
t
Ben-Wen Li CV - Page 11
o
r
a
l
F
e
l
l
o
w
,
I
n
f
e
c
t
i
o
u
s
D
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a
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D
i
v
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s
i
o
n
,
Ben-Wen Li CV - Page 12
J
e
w
i
s
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o
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p
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a
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.
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a
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Ben-Wen Li CV - Page 13
C
e
n
t
e
r
,
S
t
.
L
o
u
i
s
,
M
O
1992-1995
R
esearch
Associat
e,
Infectiou
s
Disease
s
Division,
Jewish
Hospital
at
Washin
gton
Univ.
Medical
Center,
St.
Louis,
MO
Ben-Wen Li CV - Page 14
1995-1997
R
e
s
e
a
r
c
h
I
n
s
t
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o
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,
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D
Ben-Wen Li CV - Page 15
i
v
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s
i
o
n
,
D
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p
a
r
t
m
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o
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M
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e
,
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a
s
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i
n
g
t
o
n
Ben-Wen Li CV - Page 16
U
n
i
v
e
r
s
i
t
y
S
c
h
o
o
l
o
f
M
e
d
i
c
i
n
e
1997-2005
Research Assistant Professor, Infectious Diseases Division, D
2005Research Associate Professor, Infectious Diseases Division,
Honors and Awards
IV Award of
Achievement in
Scientific Research in
China, 1986.
III Award of
Outstanding
Ben-Wen Li CV - Page 17
Achievement in
Scientific Research in
China, 1985.
Recipient of WHO
fellowship to
participate in
international
immunology training
in Geneva, 1983
Recipient of WHO
TDR Re-Entry
Research Grant,
1985.
Recipient of WHO
fellowship to
participate in an
International
Workshop on
Molecular Techniques
Applicable to the
Study of Disease
Pathogens in
Singapore, 1986.
Professional
Society and
Organizations:
American Society of
Tropical Medicine and
Hygiene
American Society of
Microbiology
Invited activities
Invited participant and
adviser, WHO Filarial
Genome Project,
Smith College,
Northampton, CT,
1995.
Invited participant and
adviser, WHO Filarial
Genome Project,
Ben-Wen Li CV - Page 18
Smith College,
Northampton, CT,
1996.
Invited participant,
Special Emphasis
Panel Teleconference
to review grant
applications for
Program
Announcement#778,
CDC, 1997.
Invited speaker,
Center for Research
and Training on
Vectors of Diseases,
Ain Shams University,
Cairo, Egypt, 1990
and 1997.
Invited participant,
Filariasis Genome
Annotation Jamboree,
TIGR, Rockville, MD
2004
Invited participant and
speaker, Joint
Filariasis and
Schistosomiasis
Genome Project
Meeting, NIH,
Bethesda, MD 2004.
Invited participant and
speaker, Keystone
symposia, Copper
Mountain, Colorado,
April 9-13, 2005
Peer Reviewed
Publications
1. Li BW, Rush
AC, Crosby
SD, Warren
WC, William
SA, Mitreva M,
Ben-Wen Li CV - Page 19
Weil GJ
Profiling of
genderregulated gene
transcripts in
the filarial
nematode
Brugia malayi
by cDNA
oliginucleotide
array analysis.
Mol & Biochem
Parasitol.
2005: 143: 4957
2. Li B W, Rush
AC, Tan J,
Weil GJ,
Quantitative
analysis of the
genderregulated
transcripts in
filarial
nematode
Brugia malayi
by real-time
RT-PCR. Mol
& Biochem
Parasitol.
2004; 137:
329-337
3. Li BW, Rush A,
Zhang SR,
Curtis KC and
Weil GJ,
Antibody
responses to
Brugia malayi
antigens
induced by
DNA
vaccination.
Ben-Wen Li CV - Page 20
Filarial Journal.
2004;3: 1.
4. Zhang SR, Li
BW, Weil GJ:
Paper
chromatograph
y hybridization:
a rapid method
for detection of
Onchocerca
volvuvus DNA
amplified by
PCR. Am.J.
Trop. Med
Hyg. 2000; 63:
85-9.
5. Weil GJ,
Steel C, Liftis
F, Li BW
Mearns G,
Lobos E,
Nutman TB:
A rapidformat
antibody
card test for
diagnosis of
Onchocercia
sis. The
Journal of
Infectious
Diseases.
2000; 182:
1796-9.
6. Li Benwen,
Zhang SR,
Curtis KC,
Weil GJ:
Immune
responses to
Brugia
malayi
paramyosin
Ben-Wen Li CV - Page 21
in rodents
after DNA
vaccination.
Vaccine.
2000; 18: 7681.
7. Zhang
Shaorong,
Benwen Li,
GJ Weil :
Human
antibody
responses to
Brugia
malayi
antigens in
brugian
filariasis.
International
Journal for
parasitology.
1999; 29:
429-436.
8. Li Benwen,
P. Hoppe,
GJ. Weil:
Cloning of an
early
immunodomi
nant filarial
antigen: a
novel
member of
the Brugia
malayi
myosin
heavy chain
gene family.
International
J
Parasitology.
1995;
25:611-19.
Ben-Wen Li CV - Page 22
9. Chandrashek
er R, KC
Curtis, Li
Benwen,
Weil GJ:
Molecular
characterizati
on of a
Brugia
malayi
intermediate
filament
protein which
is an
excretory
secretory
product of
adult worms,
Mol Biochem
Parasitol
1995;75:231239.
10. Feir, DC,
Santanello
CR, Li
Benwen , Xie
C, Weil GJ:
Evidence
supporting
the presence
of Borrelia
burgdorferi in
Missouri. Am
J Trop Med
Hyg. 1994;
51: 475-82.
11. Chandrashek
er R, Curtis
KC, Ramzy
RM, Liftis F,
Li Benwen,
Weil GJ:
Molecular
Ben-Wen Li CV - Page 23
cloning of
Brugia
malayi
antigens for
diagnosis of
lymphatic
filariasis.
Mol Biochem
Parasitol
1994;
64:261-271.
12. Li Benwen,
Chandrashek
er R, Weil
GJ:
Vaccination
with
recombinant
filarial
paramyosin
induces
partial
immunity to
Brugia
malayi
infection in
jirds. J
Immunology.
1993; 150:
1881-1885.
13. Ziao JH,
Chen CE,
Zhang WC,
Nie CX, Li
Benwen:
Comparison
of repetitive
DNA
sequences
between
Paragonimus
westermani
and
Ben-Wen Li CV - Page 24
Paragonimus
skrjabini from
six areas.
Chinese J
Parasitol &
Parasitic
Dis.1993;
11:279-81.
14. Weil GJ, Li
Benwen,
Liftis F,
Chandrashek
ar R: Brugia
malayi:
Antibody
response to
larval
antigens in
infected and
immunized
jirds. Exp
Parasitol199
2;
74:315-323.
15. Li Benwen,
Chandrashek
ar R, Alvarez
RM, Liftis F,
Weil GJ:
Identification
of
paramyosin
as a potential
protective
antigen
against
Brugia
malayi
infection in
jirds. Mol
Biochem
Parasitol
Ben-Wen Li CV - Page 25
1991;
49:315-24.
16. Li Benwen,
Lu HL, Yao
KT, Liu D:
Restriction
fragment
length
differences
of genomic
repetitive
DNA from
five sibling
species of
Anopheles
hyrcanus
group.
Chinese J
Parasitol &
Parasitic Dis.
1991; 9:8-11.
17. Zen Q, Li
Benwen,
Xiang XD, Yi
XY:
Cross-reactio
n of
oncomelania
snail protein
with
Schistosoma
japonicum
infected
human and
rabbit sera.
Bull Hunan
Med Univ.
1991;
15:58-9.
18. Li Benwen,
Lu HL, Yao
KT, Liu D, et
al:
Ben-Wen Li CV - Page 26
Restriction
fragment
length
differences
(RFLDs) of
genomic
DNA from
different
geographical
strains of
Anopheles
sinensis and
Anopheles
anthropopha
gus. Chinese
J of Parasitol
& Parasitic
Dis. 1990;
8:174-6.
19. Li Benwen,
Yao KT, et
al:
Application
of DNA
recombinatio
n technique
to
parasitologic
al research.
Chinese J. of
Parasitol and
Parasitic Dis.
1990;
8:223-6.
20. Zen Q, Li
Benwen , et
al:
Immunoblotti
ng analysis
of antigenic
components
in
Schistosomo
Ben-Wen Li CV - Page 27
ma
japonicum
different
development
al stages
with
homologous
infected
sera.
Chinese J
Exp Clin
Immunol.
1991; 2:1014.
21. Zen Q, Li
Benwen, et
al:
Immunoblot
analysis of
schistosoma
japonicum
soluble
cercariae
antigens with
infected
human and
rabbit sera.
Bull Hunan
Med Univ.
1991;
16:219-22.
22. Zen Q, Li
Benwen, et
al: An
immunoblot
analysis of
antigenic
components
in sera of
Schistosoma
japonicum
with different
development
Ben-Wen Li CV - Page 28
al stages.
International
Symposium
on
Schistosomia
sis. 1992:
217.
23. Li Benwen,
Lu HL, Pan
JF, et al: A
method for
determinatio
n of
repetitive
DNA of
mosquito
genomic
DNA. Bull
Hunan Med
Univ.
1989;14:
402-6.
24. Li Benwen,
Liu D., Xie
CS, Ye BH,
Lou HL:
Identification
of the short
arm of sex
chromosome
in the
polytene
chromosome
of the
salivary
gland of
Anopheles
sinensis.
Chinese J of
Parasitol &
Parasitic Dis.
1988; 6:118.
Ben-Wen Li CV - Page 29
25. Li Benwen,
Lu HL., Yao
KT, Liu D,
Pan JF: A
sensitive
molecular
biological
method to
differentiate
species and
strain:
Identification
of Anopheles
hycanus
complex.
Chinese J
Parasitol &
Parasitic Dis.
1988:
Supplement
p: 24.
26. Li Benwen,
Lu HL, Yao
KT, Liu D:
Restriction
Fragment
Length
Differences
in repetitive
DNA of
genomic
DNA from 5
geographical
strains of
Anopheles
sinensis and
Anopheles
anthropopha
gus.
Chinese J of
Parasitol &
Parasitic Dis.
Ben-Wen Li CV - Page 30
1988: Suppl.
p: 6.
27. Zhang HY, Li
Benwen:
Cockroaches
: The
chromosoma
l karyotype of
Periplanta
america in
the
Changsha
area. Bull
Hunan
Medical Coll.
1985;
10:737.
28. Li Benwen,
Fan W,
Zhang HY:
Study on the
chromosoma
l karyotype of
Blattla
Germanica
in Changsha
area. Bull
Hunan
Medical Coll.
1984; 9:358.
29. Li Benwen,
Ye BH:
Further
studies oh
the salivary
gland
chromosome
s of A.
sinensis.
Acta
Genetica
Sinica. 1983;
10:6.
Ben-Wen Li CV - Page 31
30. Li Benwen,
Liu D, Lou
HL: Polytene
chromosome
of the
salivary
gland of A.
sinensis 1.
Technologica
l
modifications
. Bull Hunan
Medical Coll.
1983; 8:260.
31. Li Benwen:
Polytene
chromosome
of the
salivary
gland of A.
sinensis
2.Reidentific
ation of the
Xchromosome
and
chromosome
mapping
from A.
sinensis Bull
Hunan
medical Coll.
1983; 8:267.
Ben-Wen Li
CV - Page 32
Invi
ted
publicatio
ns
1. Bo
o
Ko
e
Kw
a,
Li
Be
nw
en:
An
un
we
lco
me
co
ns
eq
ue
nc
e
of
Ch
ina
's
Ec
on
om
ic
Re
for
ms
:
Th
e
res
urg
en
ce
of
Sc
Ben-Wen Li
CV - Page 33
his
tos
om
ias
is.
De
vel
op
me
nt.
19
94;
3:3
68.
Ma
nuscripts
in
preparati
on
1. Li
BW
,
Ru
sh
AC,
Cro
sby
S,
Wa
rre
n
W,
Will
iam
s
SA,
Wei
l
GJ,
Pro
filin
g of
Bru
gia
Ben-Wen Li
CV - Page 34
mal
ayi
gen
der
reg
ulat
ed
gen
e
tran
scri
pts
by
cD
NA
olig
onu
ceo
tide
arr
ay
ana
lysi
s.
Su
bmi
te
to
MB
P
2. Mitr
eva
MD
,
Ru
sh
AC,
Wei
l
GJ
and
Li
BW
,
Ge
Ben-Wen Li
CV - Page 35
ne
exp
res
sio
n
prof
ilin
g in
irra
diat
ed
and
cult
ure
d
Bru
gia
mal
ayi
L3
by
ES
T
ana
lysi
s.
3. Li
BW
,
Hel
my
H,
Ra
mz
y
RM
R,
Hof
er
AC,
and
Wei
l
GJ,
Ide
ntifi
Ben-Wen Li
CV - Page 36
cati
on
and
cha
ract
eriz
atio
n of
a
sm
all
GT
Pas
e in
Bru
gia
mal
ayi.
4. Li
BW
,
Zha
ng
SR,
Ru
sh
AC
and
Wei
l
GJ,
Ide
ntifi
cati
on
and
cha
ract
eriz
atio
n of
a
nov
el
Bru
gia
Ben-Wen Li
CV - Page 37
mal
ayi
AL
T
prot
ein
that
is
rea
ctiv
e
wit
h
IgE
fro
m
pati
ent
s
wit
h
lym
pha
tic
filar
iasi
s.
Ab
str
act
s
pre
sen
ted
at
Nat
ion
al
or
Int
ern
ati
on
al
sci
Ben-Wen Li
CV - Page 38
ent
ific
me
eti
ng
s
(19
99200
4):
1. Zha
ng
SR,
Wei
l
GJ
,
and
Li
BW
,
Eva
luat
ion
of
thre
e
PC
Rbas
ed
met
hod
s
for
det
ecti
on
of
hu
ma
n
On
cho
cer
cia
Ben-Wen Li
CV - Page 39
sis.
199
9,
An
nua
l
Me
etin
g,
Am
eric
an
Soc
iety
of
Tro
pic
al
Me
dici
ne
and
Hy
gie
ne
(AS
TM
H).
2. Wei
l
GJ,
Ste
el
C,
Lifit
is
F,
Li
BW
,
Me
arn
s
G,
Lob
os
Ben-Wen Li
CV - Page 40
E,
and
Nut
ma
n
TB,
A
rapi
dfor
mat
anti
bod
y
car
d
test
for
dia
gno
sis
of
On
cho
cer
cia
sis.
199
9
AS
TM
H.
3. Hof
er
A,
Ho
ppe
P,
Cur
tis
KC,
Wei
l
GJ
,
Ra
Ben-Wen Li
CV - Page 41
o
UR,
and
Li
BW
,
Loc
aliz
atio
n of
rec
om
bin
ant
bru
gia
mal
ayi
prot
ein
s in
dev
elo
pin
g
em
bry
os.
199
9
AS
TM
H.
4. Li
BW
,
Hof
er
A,
Zha
ng
SR,
Cur
tis
KC
and
Ben-Wen Li
CV - Page 42
Wei
l
GJ,
Anti
bod
y
res
pon
ses
to
sin
gle
and
mul
tipl
e
Bru
gia
mal
ayi
anti
gen
s
afte
r
DN
A
vac
cin
atio
n
by
I.M.
inje
ctio
n or
gen
e
gun
in
mic
e.
199
9
AS
TM
Ben-Wen Li
CV - Page 43
H.
5. Hel
my
H,
Ra
mz
y
RM
R,
Li
BW
,
Fari
d
HA,
and
Wei
l
GJ,
Mur
ine
anti
bod
y
res
pon
ses
to
Wu
che
reri
a
ban
crof
ti
infe
ctiv
e
larv
ae.
200
0
AS
TM
H.
6. Li
Ben-Wen Li
CV - Page 44
BW
,
Hof
er
A,
Mic
hal
ski
ML,
Ra
o
UR,
and
Wei
l
GJ,
Ge
nes
diff
ere
ntia
lly
exp
res
sed
duri
ng
dev
elo
pm
ent
of
Bru
gia
mal
ayi
infe
ctiv
e
larv
ae.
200
0
AS
TM
H
Ben-Wen Li
CV - Page 45
7. Li
BW
,
Zha
ng
SR
and
Wei
l J,
A
bru
gia
mal
ayi
alle
rge
n
that
is
exp
res
sed
by
infe
ctiv
e
larv
ae
and
ho
mol
ogu
s to
abu
nda
nt
larv
al
tran
scri
pt
prot
ein
s.
200
2
Ben-Wen Li
CV - Page 46
AS
TM
H
8. Li
BW
,
Hel
my
H,
Ru
sh
A,
Ra
mz
y
RM
R
and
Wei
l
GJ,
Mic
e
inje
cte
d
wit
h
Wu
che
reri
a
ban
crift
i L3
pro
duc
e
anti
bod
ies
to a
filar
ial
Ra
s
Ben-Wen Li
CV - Page 47
sup
erfa
mil
y
ho
mol
ogu
e.
200
3
AS
TM
H
9. Li
BW
,
Ru
sh
A
and
Wei
l
GJ,
Us
e of
real
tim
e
RTPC
R
to
co
mp
are
gen
e
exp
res
sio
n in
mal
e
fem
ale
Ben-Wen Li
CV - Page 48
Bru
gia
mal
ayi
adu
lt
wor
ms.
200
3
AS
TM
H
10. Li
BW
,
Ru
sh
AC
and
Wei
l
GJ,
Us
e of
real
tim
e
RTPC
R
to
co
mp
are
gen
e
exp
res
sio
n in
mal
e
fem
ale
Ben-Wen Li
CV - Page 49
Bru
gia
mal
ayi
adu
lt
wor
ms.
200
4
2nd
Inte
rnat
ion
al
Co
ngr
ess
of
Re
altim
e
RTPC
R.
Mu
nic
h,
Ger
ma
ny.
11. Li
BW
,
Ru
sh
AC,
Cro
sby
S,
Wa
rre
n
W,
Wei
Ben-Wen Li
CV - Page 50
l
GJ.
Ide
ntifi
cati
on
of
Bru
gia
mal
ayi
sex
reg
ulat
ed
gen
es
by
cD
NA
olig
onu
cle
otid
e
arr
ays
.
Acc
ept
ed
for
pre
sen
tati
on,
AS
TM
H,
Mia
mi,
FL,
No
ve
mb
Ben-Wen Li
CV - Page 51
er
200
4.
12. Li
BW
,
Mitr
eva
M,
Ru
sh
AC,
Wei
l
GJ.
An
aly
sis
of
gen
e
exp
res
sio
n in
thre
e
typ
es
of
Bru
gia
mal
ayi
L3
cD
NA
libr
arie
s.
Acc
ept
ed
for
pre
sen
Ben-Wen Li
CV - Page 52
tati
on,
AS
TM
H,
Mia
mi,
FL,
No
ve
mb
er
200
4.
13. Li
BW
,
Ru
sh
AC,
Cro
sby
S,
Wa
rre
n
W,
Wei
l
GJ.
Pro
filin
g of
Be
ugi
a
mal
ayi
gen
der
reg
ulat
ed
tran
scri
Ben-Wen Li
CV - Page 53
pts
by
cD
NA
olig
onu
cle
otid
e
arr
ays
.
7th
inte
rnat
ion
al
mic
roa
rray
gen
e
exp
res
sio
n
soc
iety
me
etin
g in
Tor
ont
o,
Se
pt
810,
200
4.