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Fred H. Gage, Ph.D.
Adler Professor
ADDRESS
The Salk Institute
Laboratory of Genetics
10010 N. Torrey Pines Rd.
La Jolla, CA 92037
Ph: 858-453-4100 x1012
Fax: 858-597-0824
Email: gage@salk.edu
EDUCATION
1972
1975
1976
B.S. - University of Florida, Gainesville, FL
M.S. - Johns Hopkins University, Baltimore, MD
Ph.D. - Johns Hopkins University, Baltimore, MD
RESEARCH AND PROFESSIONAL EXPERIENCE
9/74-6/76
9/76-6/80
6/81-6/85
6/85-6/88
6/886/95-
NIMH Predoctoral Fellow, The Johns Hopkins University
Assistant/Associate Professor, Texas Christian University
Associate Professor, Dept. of Histology, University of Lund, Lund, Sweden
Associate Professor, Dept. of Neurosciences, University of California, San Diego
Professor, Dept. of Neurosciences, University of California, San Diego
Professor, Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA
ACADEMIC ACTIVITIES
National and
International
Committees
Member of the Wakeman Award Committee (1986-1992)
Member of the Sid Golding Research Committee (1988-present)
Member of the Committee on Social Issues: Society for Neuroscience (1988-1990)
Organizing Committee for International Neural Grafting Meetings (1988-present)
Bristol-Myers-Squibb Achievement in Neurosciences Award Committee (1987-1993)
Core Committee Member - "Frontiers in the Neurosciences", Office of Technological Assessment,
U.S. Congress (1988-1992)
Scientific Advisory Board - Alzheimer Disease and Related Disorders Association (1988-1992)
Scientific Advisory Board - American Paralysis Association (1988-1999)
Scientific Advisory Board - Hereditary Disease Foundation (1992-present)
Chairperson of the Public Information Committee of the Society for Neuroscience (1993)
Scientific Advisory Board - Encyclopedia of Neuroscience (1993)
Council Member - Society of Neuroscience (1994-1998)
Committee Member for the National Academy of Sciences - Effects of Electromagnetic Fields
on Biologic Systems (1993-1996)
Gene Vector Laboratory - Steering Committee (1995-1996)
National Advisory Council on Aging of the National Institutes of Health (1998-2001)
NIH Working Group on Guidelines for Use of Human ES Cells (1999)
Advisory Board of the American Society of Gene Therapy (1999-2002)
Chair, Scientific Advisory Board - Christopher Reeve Paralysis Foundation (1995-1999)
Ameritec Foundation Prize Technical Advisory Committee (1999-)
President Elect - Society for Neuroscience [2000-2001]
Irvine-Reeve Research Center Steering Committee [2000-2004]
President, Society for Neuroscience, [2001-2002]
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Scientific Advisory Board - Center for ALS Research at Johns Hopkins [2002]
Executive Committee of the Dana Alliance for Brain Initiatives [2002]
International Board of the Michael J. Fox Foundation [2002]
Scientific Advisory Board - The Center for ALS Research [2002]
Scientific Advisory Board - Alliance for Aging Research [2002-2003]
Scientific Advisory Board - Keystone Symposia [2002-2003]
Scientific Advisory Board – OLS Neurobiology Research Group [2003]
Award Advisory Board – The Peter Gruber Foundation [2003-2005]
Scientific Advisory Board – National University of Singapore [2003-2006]
Scientific Advisory Board – Zilkha Neurogenetic Institute [2003]
Chair-Elect of the Section on Neuroscience, AAAS [2004]
Scientific Advisory Board – California Department of Health Services [2005-2006]
Scientific Advisory Board - NAS: Beckman Center [2007-2010]
Scientific Advisory Board – NARSD [2009-]
Scientific Advisory Board – ISSCR [2009-]
Editorial
Boards
Journal of Chemical Neuroanatomy (Wiley and Sons) 1988-present
Comments on Develop. Neurobiol. (Gordon & Breech) 1987-95
Experimental Neurology (Academic Press) 1988-1998
Journal of Neuroscience (Oxford Press) 1989-1995; 1998-2004
Brain Research Bulletin (Pergamon Press) 1988-2002
Neural Plasticity (Freund Press) 1989-present
Neurobiology of Aging (Pergamon Press) 1988-present
Hippocampus (Livingston Press) 1990-present
Research and Perspectives in Alzheimer's Disease (Fondation IPSEN) 1988-present
Neuroreport (Rapid Communications of Oxford Ltd.) 1989-1994
Neurodegeneration (Academic Press) 1991-present
Journal of Neuroscience Methods, 1991-2005
Synapse, 1991-2004
Behavioral and Neural Biology (Academic Press) 1992-present
Journal of Clinical Investigation (Rockefeller University Press) 1993-2004
Gene Therapy (Stockton Press Ltd.) 1993-2003
Brain Research (Elsevier Press) 1994-present
Neuroscience (IBRO) 1994-2006
Journal of Comparative Neurology, 1995-2003
Neuropeptide (Churchill Livingstone) 1997-present
Journal of Neurobiology, 1996-present
Journal of Molecular Neuroscience, 1999
Molecular Therapy, 1999-present
Molecular Medicine Today, 1999-2001
Journal of Neuroscience Research, 1999-present
Current Drug Targets, CNS and Neurological Disorders, 2000
NeuroMolecular Medicine, 2001-present
Trends in Molecular Medicine, 2001-present
Cloning and Stem Cells, 2002-present
Associate Editor, Neuroscience Letters (Elsevier), 2003-present
Proceedings of the National Academy of Sciences, 2005-present
Cell Stem Cell, 2007-present
Genes and Development, 2009
EMBO Molecular Medicine, 2009
Awards,
Fellowships,
NIMH Predoctoral Fellowship, 1974-76
NIH Postdoctoral Fellowship (Awarded), 1976
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Honors
Fogarty International Fellowship (NSF) 1980
Visiting Professorship, University of Lund, 1981
McKnight Foundation Development Award, 1987
PEW Foundation Neuroscience's Program Award (co-recipient), 1986
Bristol-Myers Squibb Neuroscience Research Award, 1987
Grass Lecturer for Society for Neuroscience's, 1988, 1989, 1990, 1995
IPSEN Prize in Neuronal Plasticity, 1990
Ameritec Award, 1992
Metropolitan Life Award, 1993
National Institute of Health MERIT award, 1993
Decade of the Brain Medallist, Congress of Neurosurgeons, 1993
Allied Signal Award for Research in Aging, 1993
Charles A. Dana Award for Pioneering Achievement in Health and Education, 1993
The Chancellor's Associate Award, UCSD, 1994
Grass Traveling Scientist Award, 1995
Fellow AAAS, 1996
Burroughs Wellcome Visiting Professorship, 1997
The Christopher Reeve's Second Annual Medal Award, 1997
Third Annual Jus Award, 1997
The Ernst Freese Memorial Lecture, NINDS, 1997
Combined Health Agencies 1999 Health Hero Award, San Diego
The Mathilde Solowey Lecture Award in Neuroscience's, NIH, 1999
The Robert J. and Claire Pasarow Foundation Award, 1999
Max Planck Research Award, 1999
The Flynn Lecture, Yale, 1999
The Theobald Smith Lectureship Award, Albany, 2001
The Florence Mahoney Lecture, NIH, 2001
The Pinckney Harmon (Cajal Society) Lecture, 2001
The Murray Barr Lecture Award, Western Ontario, 2001
Society of Neurological Surgeons, Bass Award, 2001
Vi and John Adler Professor on Age-related Neurodegenerative Diseases, 2001
Member, Institute of Medicine of the National Academy of Sciences, 2001
MetLife Award for Medical Research, 2002
Member, National Academy of Sciences, 2003
Klaus Joachim Zulch-Preis through the Max Planck Society, 2003
Member, American Academy of Arts and Sciences, 2005
Gregory Pincus Award, shared with Alejandro Zaffaroni, 2005
Keio Medical Science Prize Award, shared with Shimon Sakaguchi, 2008
Administrative
Duties
Vice Chair, Department of Neuroscience, UCSD [1993]
Chair, Animals Investigator's Advisory Committee, Univ. of California, San Diego (1990-1993)
Graduate Council, University of California, San Diego (1991-1993)
Co-director of Laboratory of Genetics at The Salk Institute (1995-)
Academic Council - The Salk Institute (1996-1999)
Chair, Animal Facility Committee at the Salk Institute (1995-)
Chair, Academic Council at the Salk Institute (1998)
President, Society for Neuroscience (2002)
Chair Section V, Neuroscience, AAAS (2004
Chair, Board of Health Science Policy, IOM (2005-8)
Chair- Academic Council at the Salk Institute [2005/2006]
Chair, NAS Section 28 (Systems Neuroscience) NAS (2007-2009)
Member, Institute of Engineering in Medicine ORU (2008-)
Picower Advisory Council [2008-2009]
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President Elect of the International Society for Stem Cell Research [2009-2012]
PUBLICATIONS
462. Signaling in adult neurogenesis. Suh, H., Deng, W. and Gage, F.H. Annual Reviews of Cellular Developmental
Biology, in press.
461. Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis. Kuwabara, T., Hsieh, J., Muotri, A.,
Yeo, G., Warashina, M., Lie, D.C., Moore, L., Nakashima, K., Asashima, M. and Gage, F.H. Nature Neuroscience,
in press.
460. Overall, R.W., Kempermann, G., Peirce, J., Lu, L., Goldowitz, D., Gage, F.H., Goodwin, S., Smit, A.B., Airey, D.C.,
Rosen, G.D., Schalkwyk, L.C., Sutter, T.R., Nowakowski, R.S., Whatley, S. and Williams, R.W. Genetics of the
hippocampal transcriptome in mouse: a systematic survey and online neurogenomics resource. Frontiers in
Neurogenomics, in press. [Not funded by NIH]
459. Coufal, N.G., Garcia-Perez, J., Peng, G.E., Yeo, G.W., Mu, Y., Lovci, M.T., Morell, M., O’Shea, K.S., Moran, J.V., Gage,
F.H. L1 retrotransposition in human neural progenitor cells. Nature, in press.
458. Clelland, C.D., Choi, M., Romberg, C., Clemenson Jr., G.D., Fragniere, A., Tyers, P., Jessberger, S., Saksida, L.M.,
Barker, R.A., Gage, F.H. and Bussey, T.J. A functional role for adult hippocampal neurogenesis in spatial pattern
separation. Science, 325(5937): 210-213, 2009.
457. Jagasia, R., Steib, K., Englberger, E., Herold, S., Faus-Kessler, T., Saxe, M., Gage, F.H., Song, H. and Lie, D.C.
GAGA-cAMP response element-binding protein signaling regulates maturation and survival of newly generated
neurons in the adult hippocampus. The Journal of Neuroscience, 29(25): 7966-7977, 2009. [Not funded by NIH]
456. Li, Y., Mu, Y. and Gage, F.H. Chapter 5 development of neural circuits in the adult hippocampus. Current Topics in
Developmental Biology, 87: 149-74, 2009. [Not funded by NIH]
455. Andrews, M.R., Czvitkovich, S., Dassie, E., Vogelaar, C.F., Faissner, A., Blits, B., Gage, F.H., ffrench-Constant, C. and
Fawcett, J.W. Alpha9 integrin promotes neurite outgrowth on tenascin-C and enhances sensory axon regeneration.
Journal of Neuroscience, 29(17): 5546-57, 2009. [Not funded by NIH]
454. Fortun, J., Puzis, R., Pearse, D., Gage, F.H. and Bunge, M. Muscle injection of AAV-NT3 promotes anatomical
reorganization of CST axons and improves behavioral outcome following SCI. Journal of Neurotrauma, 26: 941-953,
2009. [Not funded by NIH]
453. Rose, J.B., Crews, L., Rockenstein, E., Adame, A., Mante M., Hersh, L.B., Gage, F.H., Spencer, B., Potkar, R., Marr,
R.A. and Masliah, E. Neuropeptide Y fragments derived from neprilysin processing are neuroprotective in a
transgenic model of Alzheimer’s disease. Journal of Neuroscience, 29(4): 1115-25, 2009.
452. Denli, A.M., Cao, X. and Gage, F.H. MiR-9 and TLX: Chasing tails in neural stem cells. Nat. Struct. Mol. Biol. 16 (4):
346-7, 2009.
451. Thuret, S., Toni, N., Aigner, S., Yeo, G.W. and Gage, F.H. Hippocampus-dependent learning is associated with adult
neurogenesis in MRL/MpJ mice. Hippocampus, 19: 658-669, 2009. [Not funded by NIH]
450. Zhao, C., Suh, H. and Gage, F.H. Notch keeps ependymal cells in line. Nature Neuroscience, 12(3): 243-245, 2009.
449. Jessberger, S. and Gage, F.H. Stem-cell-associated structural and functional plasticity in the aging hippocampus.
Psychology and Aging, 23(4): 684-691, 2008. [Not funded by NIH]
448. Saijo, K., Winner, B., Carson, C.T., Collier, J.G., Boyer, L., Rosenfeld, M.G., Gage, F.H. and Glass, C. A
Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced
death. Cell, 137 (1): 47-59, 2009. [Not funded by NIH]
447. Aimone, J.B., Wiles, J. and Gage, F.H. Computational influence of adult neurogenesis on memory encoding. Neuron,
61: 187-202, 2009. [PMCID: PMC2670434]
446. Jessberger, S. and Gage, F.H. Fate plasticity of adult hippocampal progenitors: biological relevance and therapeutic
use. Trends in Pharmacological Sciences, 30(2): 61-65, 2009.
445. Marumoto, T., Tashiro, A., Friedmann-Morvinski, D., Scadeng, M., Soda, Y., Gage, F.H. and Verma. I.M. Development
of a novel mouse glioma model using lentiviral vectors. Nature Medicine, 15: 110-116, 2009. [PMCID:
PMC2671237]
444. Jessberger, S., Clark, R.E., Broadbent, N.J., Clemenson Jr., G.D., Consiglio, A., Lie, D.C., Squire, L.R. and Gage, F.H.
Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats.
Learning & Memory, 16(3): 147-154, 2009. [PMCID: PMC2661246]
443. Yeo, G.W., Coufal, N.G., Liang, T.Y., Peng, G.E., Fu, X-D. and Gage, F.H. An RNA code for the FOX2 splicing
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regulator revealed by mapping RNA-protein interactions in stem cells. Nature Structural & Molecular Biology, 16(2):
130-137, 2009. [Not funded by NIH]
442. Thompson, C.L., Pathak, S.D., Jeromin, A., Ng, L.L., MacPherson, C.R., Mortrud, M.T., Cusick, A., Riley, Z.L., Sunkin,
S.M., Bernard, A., Puchalski, R.B., Gage, F.H., Jones, A.R., Bajic, V.B., Hawrylcz, M.J. and Lein, E.S. Genomic
anatomy of the hippocampus. Neuron, 60(6): 1010-21, 2008. [Accepted for publication prior to April 7, 2008]
441. Marchetto, M.C., Muotri, A.R., Mu, Y., Smith, A.M., Cezar, G.G. and Gage, F.H. Non-cell-autonomous effect of human
SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells. Cell Stem Cell, 3(6): 649-57,
2008. [Not funded by NIH]
440. Cao, X. Pfaff, S.L. and Gage, F.H. YAP regulates neural progenitor cell number via the TEA domain transcription
factor. Genes & Development, 22(23): 3320-34, 2008. [PMCID: PMC2600760]
439. Spencer, B., Marr, R.A., Rockenstein, E., Crews, L., Adame A., Potkar, R., Patrick, C., Gage, F.H., Verma, I.M. and
Masliah, E. Long-term enprilysin gene transfer is associated with reduced levels of intracellular Abeta and
behavioral improvement in APP transgenic mice. BMC Neuroscience, 9: 109, 2008. [PMCID: PMC2596170]
438. Kohyama J., Kojimi, T., Takatsuka, E., Yamashita, T., Namiki, J., Hsieh, J., Gage, F.H., Namihira, M., Okano H.,
Sawamoto, K., and Nakashima, K. Epigenetic regulation of neural cell differentiation plasticity in the adult
mammalian brain. Proceedings of the National Academy of Sciences, USA, 105(46): 18012-7, 2008. [PMCID:
PMC2584744]
437. Jessberger, S., Aigner, S., Clemenson, G.D., Toni, N., Lie, D.C., Karalay, O., Overall, R., Kempermann, G., and Gage,
F.H. Cdk5 regulates accurate maturation of newborn granule cells in the adult hippocampus. PLoS Biology,
6(11):e272, 2008. [PMCID: PMC2581629]
436. Gage, F.H. and Selzer, M.E. Experts provide insights into emerging field of brain and spine repair. Interview by Bridget
M. Kuehn. JAMA, 300(9): 1013-4, 2008.
435. Li, X., Barkho, B.Z., Luo, Y., Smrt, R.D., Santistevan, N.J., Liu, C., Kuwabara, T., Gage, F.H. and Zhao, X. Epigenic
regulation of the stem cell mitogen Fgf-2 by Mbd1 in adult neural stem/progenitor cells. Journal of Biological
Chemistry, 283(41): 27644-52, 2008. [PMCID: PMC2562066]
434. Yeo, G.W., Coufal, N., Aigner, S., Winner, B., Scholnick, J.A., Marchetto, M.C.N., Muotri, A.R., Carson, C. and Gage,
F.H. Multiple layers of molecular controls modulate self-renewal and neuronal lineage specification of embryonic
stem cells. Human Molecular Genetics, 17(1): R67-R75, 2008. [Accepted for publication prior to April 7, 2008]
433. Toni, N., Laplagne, D.A., Zhao, C., Lombardi, G., Ribak, C.E., Gage, F.H. and Schinder, A.F. Neurons born in the adult
dentate gyrus form functional synapses with target cells. Nature Neuroscience, 11(8):901-907, 2008. [PMCID:
PMC2572641]
432. Jessberger, S., Toni, N., Clemenson G.D., Ray, J. and Gage, F.H. Directed differentiation of hippocampal
stem/progenitor cells in the adult brain. Nature Neuroscience, 11(8): 888-893, 2008. [Accepted for publication prior
to April 7 2008]
431. Zhang, C-L., Zou, Y., He, W., Gage, F.H. and Evans, R.M. A role for adult TLX-positive neuroal stem cells in learning
and behavior. Nature, 451:1004-1009, 2008. [Accepted for publication prior to April 7 2008]
430. Zhao, C., Deng, W. and Gage, F.H. Mechanisms and functional implications of adult neurogenesis. Cell, 132(4):645660, 2008. [Accepted for publication prior to April 7 2008]
429. Cezar, G.G., Quam, J.A., Smith, A.M., Rosa, G.J., Piekarczyk, M.S., Brown, J.F., Gage, F.H. and Muotri, A.R.
Identification of small molecules from human embryonic stem cells using metabolomics. Stem Cells Development,
16(6): 869-882, 2007.
428. Jessberger, S., Zhao, C., Toni, N., Clemenson, G.D., Li, Y and Gage, F.H. Seizure-associated, aberrant neurogenesis
in adult rats characterized with retrovirus-mediated cell labeling. Journal of Neuroscience, 27(35):9400-9407, 2007.
427. Gage, F.H., Kempermann, G. and Song, H, Eds. Adult Neurogenesis, Cold Spring Harbor Laboratory Press, 2007.
426. Yeo, G.W., Xu, X., Liang, T.Y., Muotri, A.R., Carson, C.T., Coufal, N.G. and Gage, F.H. Alternative splicing events
identified in human embryonic stem cells and neural progenitors. PLoS Computational Biology, 3(10): 1951-1967,
2007.
425. Yao, W., Nathanson, J., Lian, I., Gage, F.H. and Sung, L.A. Mouse erythrocyte tropomodulin in the brain reported by
lacZ knocked-in downstream from the E1 promoter. Gene Expression Patterns 8:36-46, 2007.
424. Suh, H., Consiglio, A., Ray, J., Sawai, T., D'Amour, K.A. and Gage, F.H. In vivo fate analysis reveals the multipotent
and self-renewal capacities of Sox2+ neural stem cells in the adult hippocampus. Cell Stem Cell, 1:515-528, 2007.
423. Lanctot, P.M., Gage, F.H. and Varki, A.P. The glycans of stem cells. Current Opinion in Chemical Biology, 11: 373380, 2007.
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422. Aigner, S., Denli, A.M. and Gage, F.H. A novel model for an older remodeler: The BAF swap in neurogenesis. Neuron,
55: 171-173, 2007.
421. Muotri, A.R., Marchetto, M.C.N., Coufal, N.G. and Gage, F.H. The necessary junk: new functions for transposable
elements. Human Molecular Genetics, 16(2): 159-167, 2007.
420. Smrt, R.D., Eaves-Egenes, J., Barkho, B.Z., Santistevan, N.J., Zhao, C., Aimone, J.B., Gage, F.H. and Zhao, X. Mecp2
deficiency leads to delayed maturation and altered gene expression in hippocampal neurons. Neurobiology of
Disease, 27:77-89, 2007.
419. Garcia-Perez, J.L., Marchetto, M.C., Muotri, A.R., Coufal, N., Gage, F.H., Sue O'shea, K. and Moran, J.V. LINE-1
retrotransposition in human embryonic stem cells. Human Molecular Genetics, 16: 1569-1577, 2007.
418. Laplagne, D.A., Kamienkowski, J.E., Esposito, M.S., Piatti, V.C., Zhao, C., Gage, F.H. and Schinder, A.F. Similar
GABAergic inputs in dentate granule cells born during embryonic and adult neurogenesis. European Journal of
Neuroscience, 25(10): 2973-2981, 2007.
417. van Praag, H., Lucero, M.zJ., Yeo, G.W., Stecker, K., Heivand, N., Zhao, C., Yip, E., Afanador, M., Schroeter, H.,
Hammerstone, J. and Gage, F.H. Plant-derived flavanol (-)epicatechin enhances angiogenesis and retention of
spatial memory in mice. Journal of Neuroscience, 27(22): 5869-5878, 2007.
416. Jessberger, S., Nakashima, K., Clemenson, G.D. Jr., Mejia, E., Mathews, E., Ure, K., Ogawa, S., Sinton, C.M., Gage,
F.H. and Hsieh, J. Epigenetic modulation of seizure-induced neurogenesis and cognitive decline. Journal of
Neuroscience, 27(22): 5967-5975, 2007.
415. Toni, N., Teng, E.M., Bushong, E.A., Aimone, J.B., Zhao, C., Consiglio, A., van Praag, H., Martone, M.E., Ellisman,
M.H. and Gage, F.H. Synapse formation on neurons born in the adult hippocampus. Nature Neuroscience, 10(6):
727-734, 2007.
414. El-Amouri, S.S., Zhu, H., Yu, J., Gage, F.H., Verma, I.M. and Kindy, M.S. Neprilysin protects neurons against A beta
peptide toxicity. Brain Research, 1152: 191-200, 2007.
413. Tashiro, A., Makino, H. and Gage, F.H. Experience-specific functional modification of the dentate gyrus through adult
neurogenesis: a critical and immature stage. Journal of Neuroscience, 27(12): 3252-3259, 2007.
412. Leingartner, A., Thuret, S., Kroll, T.T., Chou, S-J., Leasure, J.L., Gage, F.H. and O'Leary, D.M. Cortical area size
dictates performance at modality-specific behaviors. Proceedings of the National Academy of Sciences USA,
104(10): 4153-4158, 2007.
411. Pereira, A.C., Huddleston, D.E., Brickman, A.M., Sosunov, A.A., Hen, R., McKhann, G.M., Sloan, R., Gage, F.H.,
Brown, T.R., and Small, S.A. An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus.
Proceedings of the National Academy of Sciences USA, 104(13): 5638-5643, 2007.
410. Cao, S., Pfaff, S.L. and Gage, F.H. A functional study of miR-124 in the developing neural tube. Genes and
Development, 21(5): 531-536, 2007.
409. Jessberger, S., Clemenson, G.D. Jr., and Gaqe, F.H. Spontaneous fusion and nonclonal growth of adult neural stem
cells. Stem Cells, 25(4):871-874, 2007.
408. Suzuki, S., Gerhold, L.M., Bottner, M., Rau, S.W., Dela Cruz, C., Yang, E., Zhu, H., Yu, J., Cashion, A.B., Kindy, M.S.,
Merchenthaler, I., Gage, F.H. and Wise, P.M. Estradiol enhances neurogenesis following ischemic stroke through
estrogen receptors  and . The Journal of Comparative Neurology, 500:1064-1075, 2007.
407. Jessberger, S., and Gage, F.H. Zooming In: A new high-resolution gene expression atlas of the brain. Molecular
System Biology, 3:75, 2007.
406. Miller, T.M., Kim, S.H., Yamanaka, K., Hester, M., Umapathi, P., Arnson, H., Rizo, L., Mendell, J.R., Gage, F.H.,
Cleveland, D.W. and Kaspar, B.K. Gene transfer demonstrates that muscle is not a primary target for non-cellautonomous toxicty in familial amyotrophic lateral sclerosis. Proceedings of the National Academy of Sciences USA,
103(51): 19546-19551, 2006.
405. Ramirez-Amaya, V., Marrone, D.F., Gage, F.H., Worley, P.F. and Barnes, C.A. Integration of new neurons into
functional neural networks. The Journal of Neuroscience, 26(47):12237-12241, 2006.
404. Laplagne, D.A., Esposito, M.S., Piatt, V.C., Morgenstern, N.A., Zhao, C., van Praag, H., Gage, F.H. and Schinder, A.F.
Functional convergence of neurons generated in the developing and adult hippocampus. PLoS Biology, 4(12)e409,
2006.
403. Tashiro, A., Sandler, V.M., Toni, N., Zhao, C. and Gage, F.H. NMDA-receptor-mediated, cell-specific integration of new
neurons in adult dentate gyrus. Nature, 929-933, 2006.
402. Tashiro, A., Zhao, C. and Gage, F.H. Retrovirus-mediated single-cell gene knockout technique in adult newborn
neurons in vivo. Nature Protocols, 1(6): 3049-3050, 2006.
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401. Jagasia, R., Song, H., Gage, F.H. and Lie, D.C. New regulators in adult neurogenesis and their potential role for repair.
Trends in Molecular Medicine, 12(9): 400-405, 2006.
400. Bhardwaj, R.D., Curtis, M.A., Spalding, K.L., Buchholtz, B.A., Fink, D., Bjork-Eriksson, T., Nordborg, C., Gage, F.H.,
Druld, H., Eriksson, P.S. and Frisen, J. Neocortical neurogenesis in humans is restricted to development.
Proceedings of the National Academy of Sciences USA, 103(33):12564-12568, 2006.
399. Horky, L.L., Galimi, F., Gage, F.H. and Horner, P.J. Fate of endogenous stem/progenitor cells following spinal cord
injury. Journal of Comparative Neurology, 498(4):525-538, 2006.
398. Thuret, S., Moon, L.D. and Gage, F.H. Therapeutic interventions after spinal cord injury. Nature Rev. Neuroscience,
7(8):628-643, 2006.
397. Barkho, B.Z., Song, H., Aimone, J.B., Smrt, R.D., Kuwabara, T., Nakashima, K., Gage, F.H. and Zhao, X. Identification
of astrocyte-expressed factors that modulate neural stem/progenitor cell differentiation. Stem Cell Development,
15(3):407-421, 2006.
396. Yang, H., Lu, P., MdKay, H.M., Bernot, T., Keirstead, H., Steward, O., Gage, F.H., Edgerton, V.R. and Tuszynski, M.H.
Endogenous neurogenesis replaces oligodendrocytes and astrocytes after primate spinal cord injury. Journal of
Neuroscience, 26(8):2157-2166, 2006.
395. Suzuki, A., Raya, A., Kawakami, Y., Morita, M., Matsui, T., Nakashima, K., Gage, F.H., Rodriquez-Esteban, C. and
Izpisua-Belmonte, J.C. Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of
embryonic stem cells. Proceedings of the National Academy of Sciences USA, 103(27):10294-10299, 2006.
394. Zhang, C.L., Zou, Y, Yu, R.T., Gage, F.H. and Evans, R.M. Nuclear receptor TLX prevents retinal dystrophy and
recruits the corepressor atrophin1. Genes and Development, 20(10):1308-1320, 2006.
393. Cao, X., Yeo, G., Muotri, A.R., Kuwabara, T. and Gage, F.H. Noncoding RNAs in the mammalian central nrvous
system. Annual Review of Neuroscience, 29:77-103, 2006.
392. Muotri, A.R. and Gage, F.H. Generation of neuronal variability and complexity. Nature, 44: 1087-1093, 2006.
391. Ray, J. and Gage, F.H. Differential properties of adult rat and mouse brain-derived neural stem/progenitor cells.
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390. Moon, L.D.F., Leasure, J.L. Gage, F.H. and Bunge, M.B. Motor enrichment sustains hindlimb movement recovered
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389. Jacobs, S., Lie, D.C., DeCicco, K.L., Shi, Y., DeLuca, L.M., Gage, F.H. and Evans, R.M. Retinoic acid is required early
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388. Zhao, C., Teng, E.M., Summers Jr., R.G., Ming, G-L. and Gage, F.H. Distinct morphological stages of dentate granule
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387. Genoud, S., Maricic, I., Kumar, V., and Gage, F.H. Targeted expression of IGF-1 in the central nervous system fails to
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386. Alisch, R.S., Garcia-Perez, J.L., Muotri, A.R., Gage, F.H. and Moran, J.V. Unconventional translation of mammalian
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385. Kempermann, G., Chesler, E.J., Lu, L., Williams, R.W. and Gage, F.H. Natural variation and genetic covariance in adult
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384. Borrell, V., Kaspar, B.K., Gage, F.H. and Callaway, E.M. In vivo evidence for radial migration of neurons by longdistance somal translocation in the developing Ferret visual cortex. Cerebral Cortex, 2005.
383. Battista, D., Ferrari, C.C., Gage, F.H. and Pitossi, F.J. Neurogenic niche modulation by activated microglia:
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382. Muotri, A.R., Nakashima, K., Toni, N., Sandler, V.M. and Gage, F.H. Development of functional human embryonic stem
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381. Pizzo, D.P., Coufal, N.G., Lortie, M.J., Gage, F.H. and Thal, L.J. Regulatable acetylcholine-producing fibroflasts
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380. Warashina, M., Min, K-H., Kuwabara, T., Huynh, A., Gage, F.H., Schultz, P.G. and Ding, S. A synthetic small molecule
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379. Hsieh, J. and Gage, F.H. Chromatin remodelling in neural development and plasticity. Current Opinion in Cell Biology,
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378. Lie, D-C., Colamarino, S.A., Song, H-J., Desire, L., Mira, H., Consiglio, A., Lein, E.S., Jessberger, S.., Lansford, H.,
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377. Gage, F.H. and McAllister, A.K. Neuronal and glial cell biology. Current Opinion in Neurobiology, 5: 497-499, 2005.
376. van Praag, H., Shubert, T., Zhao, C. and Gage, F.H. Exercise enhances learning and hippocampal neurogenesis in
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375. Cummings, B.J., Uchida, N., Tamaki, S.J., Salazar, D.L., Hooshmand, M., Summers, R., Gage, F.H. and Anderson, A.J.
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374. Singer, O., Marr, R.A. Rockenstein, E., Crews, L., Coufal, N.G., Gage, F.H., Verma, I.M. and Masliah, E. Targeting
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373. Aigner, S. and Gage, F.H. A small gem with great powers: Geminin keeps neural progenitors thriving. Developmental
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372. Muotri, A.R., Chu, V.T., Marchetto, M.C.N., Deng, W., Moran, J.V. and Gage, F.H. Somatic mosaicism in neuronal
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371. Myers, C.P., Lewcock, J.W., Hanson, M.G., Gosgnach, S., Aimone, J.B., Gage, F.H., Lee, K-F., Landmesser, L.T. and
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370. Lin, W., Dominguez, B., Yang, J., Aryal, P., Brandon, E.P., Gage, F.H. and Lee, K-F. Neurotransmitter acetylcholine
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369. Zupanc, G.K.H., Hinsch, K. and Gage, F.H. Proliferation, migration, neuronal differentiation, and long-term survival of
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368. Miller, T.M., Kaspar, B.K., Kops, G.J., Yamanaka, K., Christian, L.J., Gage, F.H. and Cleveland, D.W. Virus-delivered
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367. Lein, E.S., Callaway, E.M., Albright, T.D. and Gage, F.H. Redefining the boundaries of the hippocampal CA2 subfield in
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366. Scheel, J.R., Ray, J., Gage, F.H. and Barlow, C. Quantitative analysis of gene expression in living adult neural stem
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365. Galimi, F., Summers, R.G., van Praag, H., Verma, I.M. and Gage, F.H. A role for bone marrow-derived cells in the
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364. Kaspar, B.K., Frost, L.M., Christian, L., Umapathi, P. and Gage, F.H. Synergistic effects of IGF-1 and exercise in ALS.
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363. Martin, M.J., Muotri, A., Gage, F. and Varki, A. Human embryonic stem cells express an immunogenic nonhuman sialic
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363a.Schinder, A.F. and Gage, F.H. A hypothesis about the role of adult neurogenesis in hippocampal function. Physiology,
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362. Brandon, E.P., Mellott, T., Pizzo, D.P., Coufal, N., D’Amour, K.A., Gobeske, K., Lortie, M., Lopez-Coviella, I., Berse, B.,
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361. Shihabuddin, L.S., Numan, S., Huff, M.R., Dodge, J.C., Clarke, J., Macauley, S.L., Yang, W., Taksir, T.V., Parsons, G.,
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360. Hashimoto, Rockenstein, E., Mante, M., Crews, L., Bar-On, P., Gage, F.H., Marr, R. and Masliah, E. An antiaggregation
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359. Hsieh, J., Nakashima, K., Kuwabara, T., Mejia, E. and Gage, F.H. Histone deacetylase inhibition-mediated neuronal
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358. Consiglio, A., Gritti, A., Dolcetta, D., Follenzi, A., Bordignon, C., Gage, F.H., Vescovi, A.L. and Naldini, L. Robust in vivo
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357. Aimone, J.B., Leasure, J.L., Perreau, V.M., Thallmair, M. and The Christopher Reeve Paralysis Foundation Research
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356. Hsieh, J. and Gage, F.H. Epigenetic control of neural stem cell fate. Current Opinion in Genetics and Development,
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355. Wurmser, A.E., Nakashima, K., Summers, R.G., Toni, N., D’Amour, K.A., Lie, D.C. and Gage, F.H. Cell fusionindependent differentiation of neural stem cells to the endothelial lineage. Nature, 430: 350-356, 2004.
354. Pizzo, D.P., Paban, V., Coufal, N.G., Gage, F.H. and Thal, L.J. Long-term production of choline acetyltransferase in the
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353. Lie, D.C., Song, H., Colamarino, S.A., Ming, G. and Gage, F.H. Neurogenesis in the adult brain: new strategies for
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352. Wurmser, A.E., Palmer, T.D. and Gage, F.H. Cellular interactions in the stem cell niche. Science, 304: 1253-1254,
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351. Lein, E.S., Zhao, X. and Gage, F.H. Defining a molecular atlas of the hippocampus using DNA microarrays and highthroughput In Situ hybridization. The Journal of Neuroscience, 24(15): 3879-3889, 2004.
350. Kuwabara, T., Hseih, J., Nakashima, K., Taira, K. and Gage, F.H. A small modulary dsRNA specifies the fate of adult
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349. Markakis, E.A., Palmer, T.D., Randolph-Moore, L., Rakic, P. and Gage, F.H. Novel neuronal phenotypes from neural
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348. Kempermann, G., Wiskott, L, and Gage, F.H. Functional significance of adult neurogenesis. Currrent Opinion in
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347. Aimone, J.B. and Gage, F.H. Unbiased characterization of high-density oligonucleotide microarrays using probe-level
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346. Farmer, J., Zhao, X., van Praag, H., Wodtke, K., Gage, F.H. and Christie, B.R. Effects of voluntary exercise on synaptic
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345. Schaffer, D.V. and Gage, F.H. Neurogenesis and neuroadaptation. NeuroMolecular Medicine, 5:1-9, 2004.
344. Nakashima, K., Colamarino, S. and Gage, F.H. Embryonic stem cells: staying plastic on plastic. Nature Medicine,
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343. Hsieh, J., Aimone, J.B., Kaspar, B.K. Kuwabara, T., Nakashima, K, and Gage, F.H. IGF-I instructs multipotent adult
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342. Shi, Y., Lie, D.C., Taupin,j P., Nakashima, K., Ray, J., Yu, R.T., Gage, F.H. and Evans, R.M. Expression and Function
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341. Aberg, M.A.I., Aberg, N.D., Palmer, T.D., Alborn, A-M., Carlsson-Skwirut, C., Bang, P., Rosengren, L.E., Olsson, T.,
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340. Muotri, A.R. and Gage, F.H. Vibrating in the background. Nature Genetics, 35(3): 205-207, 2003.
339. Stem cells at the dawn of the 21st century. Gage, F.H. and Verma, I.M. Proc. Natl. Acad. Sci. USA, 100:11817-11818,
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338. Arvanian, V.L., Horner, P.J., Gage, F.H. and Mendell, L.M. chronic neurotrophin-3 strengthens synaptic connections to
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337. Rhodes, J.S., van Praag, H., Jeffrey, S., Girard, I., Mitchell, G.S., Garland Jr., T., and Gage, F.H. Exercise increases
hippocampal neurogenesis to high levels but does not improve spatial learning in mice bred for increased voluntary
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336. Dziewczapolski, G., Lie, D.C., Ray, J., Gage, F.H. and Shults, C.W. Survival and differentiation of adult rat-derived
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335. D’Amour, K.A. and Gage, F.H. Genetic and functional differences between multipotent neural and pluripotent
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334. Gage, F.H. Brain, repair yourself. Scientific American, September, 47-53, 2003.
333. Kaspar, B.K., Llado, J., Sherkat, N., Rothstein, J.D., and Gage, F.H. Retrograde viral delivery of IGF-1 prolongs
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332. Dickinson-Anson, H., Winkler, J., Fisher, L.J., Song, H-J., Poo, M-M., and Gage, F.H. Acetylcholine-secreting cells
improve age-induced memory deficits. Molecular Therapy, 8(1): 51-61, 2003.
331. Brown, J., Cooper-Kuhn, C.M., Kempermann, G., van Praag, H., Winkler, J., Gage, F.H. and Kuhn, G. Enriched
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330. Scheel, J.R., Garrett, L.J., Allen, D.M., carter, T.A., Randolph-Moore, L., Gambello, M.J., Gage, F.H., Wynshaw-Boris,
A. and Barlow, C. An inbred 129SvEv GFPCre transgenic mouse that deletes loxP-flanked genes in all tissues.
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329. South,S., Kohno, T., Kaspar, B.K., Hegarty, D., Vissel, B., Drake, C., Ohata, M., Jenab, S., Sailer, A.W., Malkmus, S.,
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A conditional deletion of the NMDAR1 subunit in adult cord dorsal horn reduces NMDA currents and injury-induced
pain. Journal of Neuroscience, 23(12):5031-5040, 2003.
328. Zhao, X., Ueba, T., Christie, B.R., Barkho, B., McConnell, M.J., Nakashima, K., Lein, E.s., Eadie, B.D., Whillhoite, A.R.,
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327. Brivanlou, A.H., Gage, F.H., Jaenisch, R., Jessell, T., Melton, D. and Rossant, J. Setting standards for human
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326. Klassen, H., Imfeld, K.L., Ray, J., Young, M.J., Gage, F.H. and Berman, M.A. The immunological properties of adult
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325. Marr, R.A., Rockenstien, E., Mukherjee, A., Hersh, L.B., Gage, F.H., Verma, I.M. and Masliah, E. Neprilysin gene
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324. Brandon, E.P., Lin, W., D’Amour, K.A., Pizzo, D.P. Dominquez, B., Sugiura, Y., Thode, S., Ko, C-P., Thal, L.J., Gage,
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323. Kempermann, G., Gast, D., Kronenberg, G., Yamaguchi, M. and Gage, F.H. Early determination and long-term
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322. Lai, K., Kaspar, B.K., Gage, F.H. and Schaffer, D.V. Sonic hedgehog regulates adult neural progenitor proliferation in
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321. Taupin, P., and Gage, F.H. Adult neurogenesis and neural stem cells of the central nervous system in mammals.
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320. Tamaki, S., Eckert, K., He, D., Sutton, R., Doshe, M., Jain, G., Tushinski, R., Reitsma, M., Harris, B., Tsukamoto, A.,
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319. Lie, D.C., Dziewczapolski, G., Willhoite, A.R., Kaspar, B.K., Shults, C.W. and Gage, F.H. The adult substantia nigra
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318. Kempermann, G., Gast, D. and Gage, F.H. Neuroplasticity in old age: Sustained fivefold induction of hippocampal
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317. Kempermann, G. and Gage F. H. New nerve cells for the adult brain (updated from the May 1999 issue). Scientific
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316a Song, H.-J., Stevens, C.F. and Gage, F.H. Astroglia induce neurogenesis from adult neural stem cells. Nature, 417:3944, 2002.
316. Kempermann, G. and Gage, F.H. Genetic influence on phenotypic differentiation in adult hippocampal neurogenesis.
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315. Song, H.-J., Stevens, C.F. and Gage, F.H. Neural stem cells from adult hippocampus develop essential properties of
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314. van Praag, H., Christie, B.R., Palmer, T.D. and Gage, F.H. Functional neurogenesis in the adult hippocampus. Nature,
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313. D'Amour, K.A. and Gage, F.H. Are somatic stem cells pluripotent or lineage-restricted? Nature Medicine, 8(3):213-214,
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311. Vallieres, L., Campbell, I.L., Gage, F.H. and Sawchenko, P.E. Reduced hippocampal neurogenesis in adult transgenic
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310. Kaspar, B.K., bissel, B., Bengochea, T., Crone, S., Randolph-Moore, L., Muller, R., Brandon, E.P., Schaffer, D., Verma,
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309. Kaspar, B.K., Erickson, D., Schaffer, D., Hinh, L., Gage, F.H., Peterson, D.A. Targeted retrograde gene delivery for
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308. Zhao, X., Lein, E.S., He, A., Smith, S.C., Aston, C. and Gage, F.H. Transcriptional profiling reveals strict boundaries
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307. Pfeifer, A., Brandon, E.P., Kootstra, N., Gage, F.H. and Verma, I.M. Delivery of the Cre recombinase by a self-deleting
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306. Anderson, D.J., Gage, F.H. and Weissman, I. L. Can stem cells cross lineage boundaries? Nature Medicine, 7: 393395, 2001.
305. Chu, V., and Gage, F.H. Chipping away at stem cells. Proc. Natl. Acad. Sci. USA, 98(14):7652-7653, 2001.
304. Suhr, S.t., Senut, M-C., Whitelegge, J.P., Faull, K.F., Cuizon, D.B., Gage, F.H. Identities of sequestered proteins in
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303. Matsuura, N., Lie, D.C., Hoshimaru, M., Asahi, M., Hojo, M., Ishizaki, R., Hashimoto, N., Noji, S., Ohuchi, H., Yoshioka,
H. and Gage, F.H. Sonic hedgehog facilitates dopamine differentiation in the presence of a mesencephalic glial cell
line. The Journal of Neuroscience, 21(12): 4326-4335, 2001.
302. Weissman, I.L., Anderson, D.J. and Gage, F.H. Stem and progenitor cells: Origins, phenotypes, lineage commitments,
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301. Palmer, T.D., Schwartz, P.H., Taupin, P., Kaspar, B., Stein, S.A., and Gage, F.H. Progenitor cells from human
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300. Allen, D.M., Van Praag, H., Ray, J. et al. Ataxia telangiectasia mutated is essential during adult neurogenesis. Genes &
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299. Uchida, N., Buck, D.W., He, D., Reitsma, M.J., Masek, M., Phan, T.V., Tsukamoto, A.S., Gage, F.H. and Weissman, I.L.
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298. Zoghbi, H.Y., Gage, F.H. and Choi, D.W. Neurobiology of disease. Current Opinion in Neurobiology, 10:655-660, 2000.
297. van Praag, H., Kempermann, G. and Gage, F.H. Neural consequences of environmental enrichment. Nature Review
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296. Shihabuddin, L.S., Horner, P.J., Ray, J. and Gage. F.H. Adult spinal cord stem cells generate neurons after
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295. Horner, P.J. and Gage, F.H. Regenerating the damaged central nervous system. Nature, 407: 963-970, 2000.
294. Young, M.J., Ray, J., Whiteley, S.J.O., Klassen, H. and Gage, F.H. Neuronal differentiation and morphological
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293. Taupin, P., Ray, J., Fischer, W.H., Suhr, S.T. and Gage, F.H. FGF-2 responsive neural stem cell proliferation requires CCg,
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292. Jacobs, B.L., Van Praag, H. and Gage, F.H. Depression and the birth and death of brain cells. American Scientist, 88:
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291. Palmer, T.D., Willhoite, A.R. and Gage, F.H. A vascular niche for adult hippocampal neurogenesis. The Journal of
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290. Jacobs, B.L, Van Praag, H. and Gage, F.H. Adult brain neurogenesis and psychiatry: A novel theory of depression.
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289. D'Amour, K. and Gage, F.H. New tools for human developmental biology. Nature Biotechnology, 18: 381-382, 2000.
288. Kafri, T., Van Praag, H., Gage, F.H. and Verma, I.M. Lentiviral vectors: Regulated gene expression. Molecular
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287. Gage, F.H. Mammalian neural stem cells. Science, 287: 1433-1438, 2000.
286. Horner, P.J., Power, A.E., Kempermann, G., Kuhn, H.G., Palmer, T.D., Winkler, J., Thal, L.J. and Gage. F.H.
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285. Senut, M-C., Suhr, S.T., Kaspar, B. and Gage, F.H. Intraneuronal aggregate formation and cell death after viral
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284. Spain, B.H., Larson, C.J., Shihabuddin, L.S., Gage, F.H. and Verma, I.M. Truncated BRCA2 is cytoplasmic:
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283. van Praag, H., Christie, B.R., Sejnowski, T.J. and Gage, F.H. Running enhances neurogenesis, learning and long-term
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282. van Praag, H., Kempermann, G. and Gage, F.H. Running increases cell proliferation and neurogenesis in the adult
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281. Ueba, T., Kaspar, B., Zhao, X. and Gage, F.H. Repression of human fibroblast growth factor 2 by a novel transcription
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280. Takahashi, M., Miyoshi, H., Verma, I.M. and Gage, F.H. Rescue from photo-receptor degeneration in the rd mouse
by human immunodeficiency virus vector-mediated gene transfer. Journal of Virology,73(9): 7812-7816, 1999.
279. Takahashi, J., Palmer, T.D. and Gage, F.H. Retinoic acid and neurotrophins collaborate to regulate neurogenesis in
adult-derived neural stem cell cultures. Journal of Neurobiology, 38(1): 65-81, 1999.
278. Steward, O., Schauwecker, P.E., Guth, L., Zhang, Z., Fujiki, M., Inman, D., Wrathall, J., Kempermann, G., Gage, F.H.,
Saatman, K.E., Taghupathi, R. and McIntosh, T. Genetic approaches to neurotrauma research: Opportunitites and
potential pitfalls of murine models. Experimental Neurology, 157: 19-42, 1999.
277. Smith, D.E., Roberts, J., Gage, F.H. and Tuszynski, M.H. Age-associated neuronal atrophy occurs in the primate brain and is
reversible by growth factor gene therapy. Proc. Natl. Acad. Sci., 96: 10893-10898, 1999.
276. Sakurada, K., Ohshima-Sakurada, M., Palmer, T.D. and Gage, F.H. Nurr1, an orphan nuclear receptor,
is a transcriptional activator of endogenous tyrosine hydroxylase in neural progenitor cells derived from the adult brain.
Development, 126(18): 4017-4026, 1999.
275. Peterson, D.A., Dickinson-Anson, H.A., Leppert, J.T., Lee, J-F. and Gage, F.H. Central neuronal loss and behavioral
impairment in mice lacking neurotrophin receptor p75. The Journal of Comparative Neurology, 404: 1-20, 1999.
274. Palmer, T.D., Markakis, E.A., Willhoite, A.R., Safar, F., and Gage, F.H. FGF-2 activates a latent neurogenic program in
neural stem cells from diverse regions of the adult CNS. Journal of Neuroscience, 19(19): 8487-8497, 1999.
273. Markakis, E.A. and Gage, F.H. Adult-generated neurons in the dentate gyrus send axonal projections to field CA3 and
are surrounded by synaptic vesicles. The Journal of Comparative Neurology, 406: 449-460, 1999.
272. Kempermann, G. and Gage, F.H. New nerve cells for the adult brain. Scientific American, May, 38-43, 1999.
271. Kempermann, G. and Gage, F.H. Experience-dependent regulation of adult hippocampal neurogenesis: Effects of longterm stimulation and stimulus withdrawal. Hippocampus 9:321-332, 1999.
270. Kafri, T., Van Praag, H., Ouyang, L., Gage, F.H. and Verma, I.M. A packaging cell line for lentivirus vectors. Journal of
Virology, 73(1): 576-584, 1999.
269. Winkler, J., Thal, L.J., Gage, F.H., and Fisher, L.J. Cholinergic strategies for Alzheimer’s disease. Journal of Molecular
Medicine, 76: 555-567, 1998.
268. Takahashi, M., Palmer, T.D., Takahashi, J. and Gage, F.H. Widespread integration and survival of adult-derived neural
progenitor cells in the developing optic retina. Molecular and Cellular Neuroscience 12: 340-348, 1998.
267. Suhr, S.T., Gil, Elad B., Senut, Marie-Claude, Gage, Fred H. High level transactivation by a modified Bombyx ecdysone
receptor in mammalian cells without exogenous retinoid X receptor. Proc. Natl. Acad. Sci, 95: 7999-8004, 1998.
266. Senut, M.-C., Suhr, S.T., and Gage, F.H. Gene transfer to the rodent placenta in situ. Journal of Clinical Investigation,
101: 8: 1565-1571, 1998.
265. Mulle, C., Sailer, A., Perez-Otano, I., Dickinson-Anson, H., Castillo, P.E., Bureau, I., Maron, C., Gage, F.H., Mann, J.R.,
Bettler, B. and Heinemann, S.F. Altered synaptic physiology and reduced susceptibility to kainate-induced seizures in
GluR6-deficient mice. Nature, 392: 601-605, 1998.
264. Miyoshi, H., Blomer, U., Takahashi, M., Gage, F.H. and Verma, I.M. Development of a self-inactivating lentivirus vector.
Journal of Virology, 72(10): 8150-8157, 1998.
263. McTigue, D.A., Horner, P.J., Stokes, B.T. and Gage, F.H. Neurotrophin-3 and brain-derived neurotrophic factor induce
oligodendrocyte proliferation and myelination of regenerating axons in the contused adult rat spinal cord. The Journal
of Neuroscience, 18(14): 5354-5365, 1998.
262. Kempermann, G., Kuhn, H.G., Winkler, J., and Gage, F.H. New nerve cells for the adult brain. Adult neurogenesis and
stem cell concept in neurological research. Nervenarzt, 69:851-857, 1998.
261. Kempermann, G., Kuhn, H.G., and Gage, F.H. Experience-induced neurogenesis in the senescent dentate gyrus. The
Journal of Neuroscience, , 18(9): 3206-3212, 1998.
260. Kempermann, G., Brandon, E.P. and Gage, F.H. Environmental stimulation of 129/SvJ mice causes increased cell
proliferation and neurogenesis in the adult dentate gyrus. Current Biology, 8(16): 939-942, 1998.
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259. Gage, F.H., Kempermann, G., Palmer, T.D., Peterson, D.A. and Ray J. Multipotent progenitor cells in the adult dentate
gyrus. The Journal of Neurobiology, 249-266, 1998.
258. Gage, F.H. Discussion point: Stem cells of the central nervous system. Current Opinion in Neurobiology, 8: 671-676,
1998.
257. Gage, F.H. Cell therapy. Nature, 18-24, 1998.
256. Eriksson, P.S., Perfilieva, E., Bjork-Eriksson, T., Alborn, A-M., Nordborg, C., Peterson, D.A., and Gage, F.H.
Neurogenesis in the adult human hippocampus. Nature Medicine, 4(11): 1313-1317, 1998.
255. Dickinson-Anson, H., Aubert, I., Gage, F.H. and Fisher, L.J. Hippocampal grafts of acetylcholine-producing cells are
sufficient to improve behavioral performance following a unilateral fimbria-fornix lesion. Neuroscience, 84(3): 771-781,
1998.
254. Chiang, M-Y., Misner, D., Kempermann, G., Schikorski, T., Gage, F.H., Stevens, C.F. and Evans, F.M. An essential
role for retinoid receptors RARß and RXR¥ in long-term potentiation and depression. Neuron 21: 1353-1361, 1998.
253. Blomer, U., Kafri, T., Randolph-Moore, L., Verma, I.M. and Gage, F.H. Bcl-xL protects adult septal cholinergic neurons
from axotomized cell death. Proc. Natl. Acad. Sci. USA, 95:2603-2608, 1998.
252. Berger, F., Gage, F.H. and Vijayaraghavan, S. Nicotinic Receptor-induced apoptotic cell death of hippocampal progenitor
cells. The Journal of Neuroscience, 18(7): 6871-6881, 1998.
251. Aubert, I., Ridet, J-L., Schachner, M., Rougon, G. and Gage, F.H. Expression of L1 and PSA during sprouting and
regeneration in the adult hippocampal formation. The Journal of Comparative Neurology, 399: 1-9, 1998.
250. Winkler, J., Ramirez, G.A., Kuhn, G., Peterson, D.A., Day-Lollini, P.A., Stewart, G.R., Tuszynski, M.H., Gage, F.H. and
Thal, L.J. Reversible schwann cell hyperplasia and sprouting of sensory and sympathetic neurites after intraventricular
administration of nerve growth factor. Annals of Neurol., 41 (1): 82-93, 1997.
249. Schinstine, M., Ray, J. and Gage F.H. Potential effect of cytokines on transgene expression in primary fibroblasts
implanted into the rat brain. Molecular Brain Research, 47: 195-201, 1997.
248. Sah, D.W.Y., Ray, J. and Gage, F.H. Regulation of voltage-and ligand-gated currents in rat hippocampal progenitor cells
in vitro. Journal of Neurobiology 32:95-110, 1997.
247. Sah, D.W.Y., Ray, J. and Gage, F.H. Bipotent progenitor cell lines from the human CNS. Nature Biotechnology, 15: 574580, 1997.
247. Shihabuddin, L.S., Ray, J. and Gage, F.H. FGF-2 is sufficient to isolate progenitors found in the adult mammalian spinal
cord. Experimental Neurology 148: 577-586, 1997.
246. Ridet, J.L., Malhotra, S.K., Privat, A. and Gage, F.H. Reactive astrocytes: Cellular and molecular cues to biological
function. TINS, 20: 570-577, 1997.
245. Raymon, H.K., Thode, S. and Gage, F.H. Application of ex vivo gene therapy in the treatment of Parkinson’s disease.
Experimental Neurology, 144: 82-91, 1997.
244. Ray, J., Baird, A. and Gage, F.H. A 10-amino acid sequence of fibroblast growth factor 2 is sufficient for its mitogenic
activity on neural progenitor cells. Proc. Natl. Acad. Sci. USA, 94: 7047-7052, 1997.
243. Peterson, D.A., Leppert, J.T., Lee, K-F., and Gage, F.H. Basal forebrain neuronal loss in mice lacking neurotrophin
receptor p75. Science, 277: 837-838, 1997.
242. Palmer, T.D., Takahashi, J. and Gage, F.H. The adult rat hippocampus contains primardial neural stem cells. Molecular
and Cellular Neuroscience, 8: 389-404, 1997.
241. Miyoshi, H., Takahashi, M., Gage, F.H. and Verma, I.M. Stable and efficient gene transfer into the retina using an HIVbased lentiviral vector. Proc. Natl. Acad. Sci. USA, 94: 10319-10323, 1997.
240. Kuhn, H.G., Winkler, J., Kempermann, G., Thal, L.J. and Gage, F.H. Epidermal growth factor and fibroblast growth
factor-2 have different effects on neural progenitors in the adult rat brain. The Journal of Neuroscience, 17(15): 58205829, 1997.
239. Kempermann, G., Kuhn, H.G. and Gage, F.H. More hippocampal neurons in adult mice living in an enriched
environment. Nature, 386: 493, 1997.
238. Kempermann, G., Kuhn, H.G., and Gage, F.H. Genetic influence on neurogenesis in the dentate gyrus of adult mice.
Proc. Natl. Acad. Sci. USA, 94: 10409-10414, 1997.
237. Kafri, T., Blomer, U., Peterson, D.A., Gage, F.H. and Verma, I.M. Sustained expression of genes delivered directly into
liver and muscle by lentiviral vectors. Nature Genetics 17:314-317, 1997.
236. Grill, R., Murai, K., Blesch, A., Gage, F.H. and Tuszynski, M.H. Cellular delivery of neurotrophin-3 promotes corticospinal
axonal growth and partial functional recovery after spinal cord injury. Journal of Neuroscience, 17(14: 5560-5572,
1997.
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235. Fagan, A.M., Suhr, S.T., Lucidi-Phillipi, C.A., Peterson, D.A., Holtzman, D.M. and Gage, F.H. Endogenous FGF-2 is
important for cholinergic sprouting in the denervated hippocampus. The Journal of Neuroscience, 17(7): 2499-2511,
1997.
234. Blomer, U., Naldini, L., Kafri, T., Trono, D., Verma, I.M. and Gage, F.H. Highly efficient and sustained gene transfer in
adult neurons with a lentivirus vector. Journal of Virology, 71(9):6641-6649, 1997.
233. Tuszynski, M.H. and Gage, F.H. Maintaining the neuronal phenotype after injury in the adult CNS: Neurotrophic factors,
axonal growth substrates and gene therapy. Molecular Neurobiology, 1996.
232. Tuszynski, M.H., Roberts, J., Senut, M-C. and Gage, F.H. Gene therapy in the adult primate brain: Intraparenchymal
grafts of cells genetically modified to produce nerve growth factor prevent cholinergic neuronal degeneration. Gene
Therapy, 3: 305-314, 1996.
231. Suhonen, J.O., Peterson, D.A., Ray, J. and Gage, F.H. Differentiation of adult hippocampus-derived progenitors into
olfactory neurons in vivo. Nature, 383: 624-627, 1996.
230. Peterson, D.A., Lucidi-Phillipi, C.A., Murphy, D.P., Ray, J., and Gage, F.H. FGF-2 protects entorhinal layer II
glutamatergic neurons from axotomy-induced death. The Journal of Neuroscience, 16(3): 886-898, 1996.
229. Naldini, L., Blomer, U., Gallay, Pl, Gage, F.H., Verma, I.M., and Trono, D. In vivo gene delivery and stable transduction of
postmitotic cells by a lentiviral vector. Science, 272: 263-267, 1996.
228. Naldini, L., Blomer, U., Gage, F.H., Trono, D. and Verma, I.M. Efficient transfer, integration, and sustained long-term
expression of the transgene in adult rat brains injected with a lentiviral vector. Proc. Natl. Acad. Sci. USA, 93: 1138211388, 1996.
227. Nakajima, T., Fukamizu, A., Takahashi, J., Gage, F.H., Fisher, T., Blenis, J. and Montminy, M. The signal dependent coactivator CBP is a nuclear target for pp90RSK. Cell, 86: 465-474, 1996.
226. Minger, S.L., Fisher, L.J., Ray, J. and Gage, F.H. Long-term survival of transplanted basal forebrain cells following in
vitro propagation with fibroblast growth factor-2. Experimental Neurology, 141: 12-24, 1996.
225. Lucici-Phillipi, C.A., Clary, D.O., Reichardt, L.F., and Gage, F.H. TrkA activation is sufficient to rescue axotomized
cholinergic neurons. Neuron, 16: 1-20, 1996.
224. Lipkin, S.M, Grider, T.L., Heyman, R.A., Glass, C.K., and Gage, F.H. Constitutive retinoid receptors expressed from
adenovirus vectors that specifically activate chromosomal target genes required for differentiation of promyelocytic
leukemia and teratocarcinoma cells. Journal of Virology, 70(10): 7182-7189, 1996.
223. Kuhn, H.G., Dickinson-Anson, H., and Gage, F.H. Neurogenesis in the dentate gyrus of the adult rat: Age-related
decrease of neuronal progenitor proliferation. The Journal of Neuroscience, 16(6): 2027-2033, 1996.
222. Hoshimaru, M., Ray, J., Sah, D.W.Y., and Gage, F.H. Differentiation of the immortalized adult neuronal progenitor cell
line HC2S2 into neurons by regulatable suppression of the v-myc oncogene. Proceedings of the National Academy of
Science USA , 93: 1518-1523, 1996.
221. Eagle, K.S., Chalmers, G.C., Clary, D.O., and Gage, F.H. Axonal regeneration and limited functional recovery following
hippocampal deafferentation. The Journal of Comparative Neurology, 363: 377-388, 1996.
220. Chalmers, G.R., Peterson, D.A., and Gage, F.H. Sprouting adult CNS cholinergic axons express nile and associate with
astrocytic surfaces expressing neural cell adhesion molecule. The Journal of Comparative Neurology, 371: 287-299,
1996.
219. Blomer, U., Naldini, L., Verma, I.M., Trono, D., and Gage, F.H. Applications of gene therapy to the CNS. Human
Molecular Genetics, 5: 1397-1404, 1996.
218. Winkler, J., Suhr, S.T., Gage, F.H., Thal, L.J., and Fisher, L.J. Essential role of neocortical acetylcholine in spatial
memory. Nature, 375: 484-487, 1995.
217. Tuszynski, M.H., and Gage, F.H. Bridging grafts and transient nerve growth factor infusions promote long-term central
nervous system neuronal rescue and partial functional recovery. Proceedings of the National Academy of Science
USA, 92: 4621-4625, 1995.
216. Takayama, H., Ray, J., Raymon, H.K., Baird, A., Hogg, J. Fisher, J, and Gage, F.H. Basic fibroblast growth factor
increases dopaminergic graft survival and function in a rat model of Parkinson’s disease. Nature Medicine, 1 (1): 5358, 1995.
215. Senut, M-C., Tuszynski, M.H., Raymon, H.K., Suhr, S.T., Liou, N.H., Jones, K.R., Reichardt, L.F., and Gage, F.H.
Regional differences in responsiveness of adult CNS axons to grafts of cells expressing human neurotrophin 3.
Experimental Neurology 135: 36-55, 1995.
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214. Ray, J., Hogg, J., Beutler, A.S., Takayama, H., Baird, A., and Gage, F.H. Expression of biologically active basic fibroblast
growth factor by genetically modified rat primary skin fibroblasts. Journal of Neurochemistry, 64(2): 503-513, 1995.
213. Palmer, T.D., Ray, J., and Gage, F.H. FGF-2 responsive neuronal progenitors reside in proliferative and quiescent
regions of the adult rodent brain. Molecular & Cellular Neuroscince, 6:474-486, 1995.
212. Niijima, K., Chalmers, G.R., Peterson, D.A., Fisher, L.J., Patterson, P.H., and Gage, F.H. Enhanced survival and neuronal
differentiation of adrenal chromaffin cells co-grafted into the striatum with NGF-producing fibroblasts. Journal of
Neuroscience, 15(2): 1180-1194, 1995.
211. Lucidi-Phillipi, C.A., Gage, F.H., Shults, C.W., Jones, K.R., Reichardt, L.F., and Kang, U.J. BDNF-transduced fibroblasts:
Production of BDNF and effects of grafting to the adult rat brain. Journal of Comparative Neurol.,354(3):3 61-76,1995.
210. Gage, F.H., Ray, J., and Fisher, L.J. Isolation, characterization, and use of stem cells from CNS. In: Annual Review of
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209. Gage, F.H., Coates, P.W., Palmer, T.D., Kuhn, H.G., Fisher, L.J., Suhonen, J.O., Peterson D.A., Suhr, S.T., and Ray, J.
Survival and differentation of adult neuronal progenitor cells transplanted to the adult brain. Proceedings of the
National Academy of Sciences, 92: 11879-11883, 1995.
208. Fisher, L.J. and Gage, F.H. Radical directions in Parkinson's disease. Nature Medicine, 1(3): 201-203, 1995.
207. Fisher, L.J. and Gage, F.H. Novel therapeutic directions for Parkinson’s disease. Molecular Medicine Today, 181-187,
1995.
206. Eagle, K.S., Chalmers, G.R., Clary, D.O. and Gage, F.H. Axonal regeneration and limited functional recovery following
hippocampal deafferentation. Journal of Comparative Neurology, 363: 377-388, 1995.
205. Chen, K.S., Masliah, E., Mallory, M. and Gage, F.H. Synaptic loss in cognitively impaired aged rats is ameliorated by
chronic human nerve growth factor infusion. Neuroscience, 68(1): 19-27, 1995.
204. Chen, K.S. and Gage, F.H. Somatic gene transfer of NGF to the aged brain: Behavioral and morphological amelioration.
The Journal of Neuroscience, 15(4): 2819-2825, 1995.
203. Chalmers, G.R., Fisher, L.J., Niijima, K., Patterson, P.H., and Gage, F.H. Adrenal chromaffin cells transdifferentiate in
response to basic fibroblast growth factor and show directed outgrowth to a nerve growth factor source in
vivo. Experimental Neurology 133: 32-42, 1995.
202. Beutler, A.S., Banck, M.S., Bach, F.W., Gage, F.H., Porreca, F., Bilsky, E.J., and Yaksh, T.L. Retrovirus mediated
-endorphin precursor in primary fibroblasts. Journal of Neurochemistry, 64(2): 475-481,
1995.
201. Aubert, I., Ridet, J.-L., and Gage, F.H. Regeneration in the adult mammalian CNS: Guided by development. Current
Opinion in Neurobiology, 5:625-635, 1995.
200. Tuszynski, M.H., Senut, M-C, Ray, J., Roberts, J., U, H-S., and Gage, F.H. Somatic gene transfer to the adult primate
central nervous system: in vitro and in vivo characterization of cells genetically modified to secrete nerve growth factor.
Neurobiology of Disease, 1: 67-78, 1994.
199. Tuszynski, M.H., Peterson, D.A., Ray, J., Baird, A., and Gage, F.H. Fibroblasts genetically modified to produce nerve
growth factor induce robust neuritic ingrowth after grafting to the spinal cord. Submitted to Experimental Neurology,
126: 1-14, 1994.
198. Ray, J. and Gage, F.H. Spinal cord neuroblasts proliferate in response to basic fibroblast growth factor. Journal of
Neuroscience, 14(6): 3548-3564, 1994.
197. Peterson, D.A., Lucidi-Phillipi, C.A., Eagle, K.L., and Gage, F.H. Perforant path damage results in progressive neuronal
death and somal atrophy in layer II of entorhinal cortex and functional impairment with increasing post-damage age.
Journal of Neuroscience, 14(11): 6872-6885, 1994.
196. Gonzalez, A.M., Carman, L.S., Ong, M., Ray, J., Gage, F.H., Shults, C.W., and Baird, A. Storage, metabolism, and
processing of [125I]-fibroblast growth factor-2 after intracerebral injection. Brain Research, 665: 285-292, 1994.
195. Gage, F.H. Neuronal stem cells:Their characterization and utilization. Neurobiology of Aging, 15 (2): S191, 1994.
194. Fisher, L.J., and Gage, F.H. Intracerebral transplantation: Basic and clinical applications to the neostriatum.
The FASEB Journal, 8: 489-496, 1994.
193. Fagan, A.M., and Gage, F.H. Mechanisms of sprouting in the adult CNS: Cellular responses in areas
of terminal degeneration and reinnervation in the rat hippocampus. Neuroscience, 58(4): 705-725, 1994.
192. Dekker, A.J., Winkler, J., Ray, J., Thal, L.J., and Gage, F.H. Grafting of nerve growth factor-producing fibroblasts
reduces behavioral deficits in rats with lesions of the nucleus basalis magnocellularis. Neuroscience, 60(2): 299-309,
1994.
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191. Dekker, A.J., Fagan, A.M., Gage, F.H., and Thal, L.J. Effects of brain-derived neurotrophic factor and nerve growth factor
on remaining neurons in the lesioned nucleus basalis magnocellularis. Brain Research 639: 149-155, 1994.
190. Beeson, J.G., Shelton, E.R., Chan, H.W., and Gage, F.H. Differential distribution of amyloid protein precursor
immunoreactivity in the rat brain studied by using five different antibodies.
The Journal of Comparative Neurology, 340: 10-19, 1994.
189. Beeson, J.G., Shelton, E.R., Chan, H.W., and Gage, F.H. Age and damage induced changes in amyloid protein
precursor immunohistochemistry in the rat brain. The Journal of Comparative Neurology, 340: 1-9, 1994.
188. Barba, D., Hardin, J., Sadelain, M., and Gage, F.H. Development of anti-tumor immunity following thymidine kinasemediated killing of experimental brain tumors. Proceedings of the National Academy of Sciences, 91: 4348-4352,
1994.
187. Suhr, S.T., and Gage, F.H. Gene therapy for neurological disease. Archives of Neurology, 50: 1252-1268, 1993.
186. Shimohama, S., Saitoh, T., and Gage, F.H. Changes in protein kinase C isozymes in the rat hippocampal formation
following hippocampal lesion. Hippocampus, 3(1): 43-56, 1993.
185. Ray, J., Peterson, D.A., Schinstine, M., and Gage, F.H. Proliferation, differentiation, and long-term culture of primary
hippocampal neurons. Proceedings of the National Academy of Sciences, 90:3602-3606, 1993.
184. Ray, J. and Gage, F.H. Production of genetically modified cells expressing specific transgenes by retroviral vectors for
gene therapy. Journal of Tissue Culture Methods 15: 108-115, 1993.
183. Nilsson, O.G., Gage, F.H. Anticholinergic sensitivity in the aging rat septohippocampal system as assessed in a spatial
memory task. Neurobiology of Aging 14: 487-497, 1993.
182. Kang, U.J., Fisher, L.J., Jinnah, H.A., Rosenberg, M.B., Joh, T.H., O’Malley, K.L., and Gage, F.H. Regulation of
dopamine production by genetically modified primary fibroblasts. Journal of Neuroscience, 13(12): 5203-5211, 1993.
181. Holtzman, D.M., Li, Y., Chen, K., Gage, F.H., Epstein, C.J., and Mobley, W.C. Nerve growth factor reverses neuronal
atrophy in a Down syndrome model of age-related neurodegeneration. Neurology, 43(12): 2668-2673, 1993.
180. Gage, F.H. Fetal implants put to the test. Nature, 361: 405-406, 1993.
179. Fisher, L.J., Schinstine, M., Salveterra, P., Dekker, A.J., Thal, L., and Gage, F.H. In vivo production
and release of acetylcholine from primary fibroblasts genetically modified to express choline acetyltransferase. Journal
of Neurochemistry, 61: 1323-1332, 1993.
178. Fisher, L.J., and Gage, F.H. Grafting in the mammalian central nervous system. Physiological Reviews, 73(3): 583-616,
1993.
177. Barba, D., Hardin, J., Ray, J., and Gage, F.H. Thymidine kinase mediated killing of rat brain tumors. Journal of
Neurosurgery, 79: 729-735, 1993.
176. Armstrong, D.M., Sheffield, R., Buzsaki, G., Chen K.S., Hersh, L.B., Nearing, B., Gage, F.H. Morphologic alterations of
choline acetyltransferase-positive neurons in the basal forebrain of aged behaviorally characterized Fisher 344 rats.
Neurobiology of Aging, 14: 457-470, 1993.
175. Yoshida, K., Kakihana, M., Chen, L.S., Ong, M., Baird, A. and Gage, F.H. Cytokines regulation of NGF-mediated
cholinergic neurotrophic activity in astrocytes and fibroblasts. Journal of Neurochemistry, 59(3): 919-931, 1992.
174. Yoshida, K., and Gage, F.H. Cooperative regulation of nerve growth factor synthesis and secretion in fibroblasts and
astrocytes by fibroblast growth factor and other cytokines. Brain Res., 569: 14-25, 1992.
173. Schinstine, M., Rosenberg, M.B., Routledge-Ward, C., Friedmann, T., and Gage, F.H. Effects of choline and quiescence
on Drosophila choline acetyltransferase expression and acetylcholine production by transduced rat fibroblasts. Journal
of Neurochemistry, 2019-2029, 1992.
172. Ray, J., and Gage, F.H. Gene transfer into established and primary fibroblast cell lines: Comparison of transfection
methods and promoters. BioTechniques, 13(4): 598-603, 1992.
171. Kawaja, M.D., Rosenberg, M.B., Yoshida, K., and Gage, F.H. Somatic gene transfer of nerve growth factor promotes the
survival of axotomized septal neurons and the regeneration of their axons in adult rats. Journal of Neuroscience,
12(7):2849-2864, 1992.
170. Kawaja, M.D., and Gage, F.H. Morphological and neurochemical features of cultured primary skin fibroblasts of Fischer
344 rats following striatal implantation. The Journal of Comparative Neurology, 317:102-116, 1992.
169. Johnson, P.A., Yoshida. K., Gage, F.H., and Friedmann, T. Effects of gene transfer into cultured CNS neurons with a
replication-defective herpes simplex virus type 1 vector. Mol. Brain Research, 12: 95-102, 1992.
168. Jinnah, H.A., Hess, E.J., Wilson, M.C., Gage, F.H., and Friedmann, T. Localization of Hypoxanthine-guanine
phosphoribosyltransferase mRNA in the mouse brain by in situ hybridization. Molecular and Cellular Neurosciences,
3:64-78, 1992.
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167. Holtzman, D.M., Wen Li, Y., DeArmond, S.J., McKinley, M.P., Gage, F.H., Epstein, C.J., and Mobley, W.C.
A mouse model of selective neurodegeneration: Atrophy of basal forebrain cholinergic neurons in Ts 16 transplants.
Proceedings of the National Academy of Sciences, 89: 1383-1387, 1992.
166. Gage, Fred H. Repopulating the mortal brain with immortal cells. Current Biology, 2(5): 232-234, 1992.
165. Gage, F.H., and Chen, K.S. Neural transplants: Prospects for Alzheimer's disease. Current Opinion in Neurology &
Neurosurgery, 5: 94-99, 1992.
164. Dekker, A.J., Gage, F.H., and Thal, L.J. Delayed treatment with nerve growth factor improves acquisition of a spatial task
in rats with lesions of the nucleus basalis magnocellularis: Evaluation of the involvement of different neurotransmitter
systems. Neuroscience, 48(1): 111-119, 1992.
163. Yoshida, K., and Gage, F.H. Fibroblast growth factors stimulate nerve growth factor synthesis and secretion by
astrocytes. Brain Research, 538: 118-126, 1991.
162. Tuszynski, M.H., U, H.S., Yoshida, K., and Gage, F.H. Recombinant human nerve growth factor infusions prevent
cholinergic neuronal degeneration in adult primate brain. Annals of Neurol., 30(5): 625-636, 1991.
161. Thal, L.J., Gilbertson, E., Armstrong, D.M., and Gage, F.H. Development of the basal forebrain cholinergic system:
Phenotype expression prior to target innervation. Neurobiology of Aging, 13: 67-72, 1991.
160. Shults, C.W., O'Connor, D.T., Baird, A., Hill, R., Goetz, C.G., Watts, R.L., Klawans, H.L., Carvey, P.M., Bakay, R.A.,
Gage, F.H., and U, H.S. Clinical improvement in parkinsonian patients undergoing adrenal to caudate transplantation
is not reflected by chromogranin A or basic fibroblast growth factor in ventricular fluid. Experimental Neurology, 111:
276-281, 1991.
159. Masliah, E., Fagan, A.M., Terry, R.D., DeTeresa, R., Mallory, M., and Gage, F.H. Reactive synaptogenesis assessed by
synaptophysin immunoreactivity is associated with GAP-43 in the dentate gyrus of the adult rat. Experimental
Neurology, 113: 131-142, 1991.
158. Lyden, P.D., Zivin, J.A., Chabolla, D.R., Jacobs, M.A., and Gage, F.H. Quantitative effects of cerebral infarction on spatial
learning. Experimental Neurology, 1991.
157. Kawaja, M.D., and Gage, Fred H. Reactive astrocytes are substrates for the growth of adult CNS axons in the presence
of elevated levels of nerve growth factor. Neuron, 7: 1019-1030, 1991.
156. Kawaja, M.D. and Gage, F.H. Nerve growth factor receptor immunoreactivity in the rat septo-hippocampal pathway: A
light and electron microscope investigation. Journal of Comparative Neurology, 307: 517-529, 1991.
155. Kawaja, M.D., Fagan, A.M., Firestein, B.L., and Gage, F.H. Intracerebral grafting of cultured autologous skin fibroblasts
within the rat striatum: An assessment of graft size and ultra- structure. Journal of Comparative Neurology, 307: 695706, 1991.
154. Gage, F.H., Kawaja, M.D., and Fisher, L.J. Genetically modified cells: Applications for intracerebral grafting. Trends in
Neurosciences, 14(8): 328-333, 1991.
153. Gage, F.H., Kang, U.J. and Fisher, L.J. Intracerebral grafting in the dopaminergic system: Issues and controversy.
Current Opinion in Neurobiology, 414-419, 1991.
152. Gage, F.H. and Fisher, L.J. Intracerebral grafting: A tool for the neurobiologist. Neuron, 6: 1-12, 1991.
151. Fisher, L.J., Jinnah, H.A., Kale, L.C., Higgins, G.A. and Gage, F.H. Survival and function of intrastriatally grafted primary
fibroblasts genetically modified to produce L-dopa. Neuron, 6: 1-20, 1991.
150. Fisher, L.J., Young, S.J., Tepper, J.M., Groves, P.M., and Gage, F.H. Electrophysiological characteristics of cells within
mesencephalon suspension grafts. Neuroscience, 40(1): 109-122, 1991.
149. Fischer, W., Chen, K.S., Gage, F.H., and Bjorklund, A. Progressive decline in spatial learning and integrity of forebrain
cholinergic neurons in rats during aging. Neurobiology of Aging, 13: 9-23, 1991.
148. Fischer, W., Bjorklund, A., Chen, K., and Gage, F.H. NGF improves spatial memory in aged rodents as a function of age.
The Journal of Neuroscience, 11(7):1889-1906, 1991.
147. Dekker, A.J., Langdon, D.J., Gage, F.H., and Thal, L.J. NGF increases cortical acetylcholine release in rats with lesions
of the nucleus basalis. NeuroReport 2: 577-580, 1991.
146. Dawson, T.M., Dawson, V.L., Gage, F.H., Fisher, L.J., Hunt, M.A., and Wamsley, J.K. Downregulation of muscarinic
receptors in the rat caudate-putamen after lesioning of the ipsilateral nigrostriatal dopamine pathway with 6hydroxydopamine (6-OHDA): normalization by fetal mesencephalic transplants. Brain Research, 540: 145-152, 1991.
145. Chen, L. S., Ray, J., Fisher, L. J., Kawaja, M. D., Schinstine, M., Kang, U. J., and Gage, F.H. Cellular replacement
therapy for neurologic disorders: Potential of genetically engineered cells. Journal of Cellular Biochemistry, 45: 252257, 1991.
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144. Buzsaki, G., Masliah, E., Chen, L.S., Horvath, Z., Terry, R. and Gage, F.H. Hippocampal grafts into the intact brain
induce epileptic patterns. Brain Research, 554: 30-37, 1991.
143. Buzsaki, G., Hsu, M., Slamka, C., Gage, F.H., and Horvath, Z. Emergence and propagation of interictal spikes in the
subcortically denervated hippocampus. Hippocampus 1(1): 163-180, 1991.
142. Tuszynski, M.H., U, H.S., Amaral, D.G. and Gage, F.H. Nerve growth factor infusion in the primate brain reduces lesioninduced cholinergic neuronal degeneration. Journal of Neuroscience, 10(11): 3604-3615, 1990.
141. Tuszynski, M.H., and Gage, F.H. Potential use of neurotrophic agents in the treatment of neurodegenerative disorders.
Acta Neurobiol. Exp., 50: 311-322, 1990.
140. Tuszynski, M.H., Buzsaki, G. and Gage, F.H. NGF infusions combined with fetal hippocampal grafts enhance
reconstruction of the lesioned septohippocampal projection. Neuroscience, 36(1): 33-44, 1990.
139. Tuszynski, M.H., Armstrong, D.M., and Gage, F.H. Basal forebrain cell loss following fimbria/fornix transection. Brain
Research, 508:241-248, 1990.
138. Thal, L.J., Mandel, R.J., Terry, R.D., Buzsaki, G. and Gage, F.H. Nucleus basalis lesions fail to induce senile plaques in
the rat. Experimental Neurology, 108: 88-90, 1990.
137. Shults, C.W., Hashimoto, R., Brady, R.M. and Gage, F.H. Dopaminergic cells align along radial glia in the developing
mesencephalon of the rat. Neuroscience, 38(2): 427-436, 1990.
136. Jinnah, H.A., Gage, F.H., and Friedmann, T. Animal models of Lesch-Nyhan syndrome. Brain Research Bulletin, 25: 467475, 1990.
135. Higgins, G.A., Oyler, G.A., Neve, R.L., Chen, K.S. and Gage, F.H. Altered levels of amyloid protein precursor transcripts in
the basal forebrain of behaviorally impaired aged rats. Proceedings of the National Academy of Sciences, 87: 30323034, 1990.
134. Gage, F.H. Intracerebral grafting of genetically modified cells acting as biological pumps. In: Trends in Pharmacological
Sciences, 11(11): 437-439, 1990.
133. Fagan, A.M. and Gage, F.H. Cholinergic sprouting in the hippocampus: A proposed role for IL-1. Experimental
Neurology, 110: 105-120, 1990.
132. Buzsaki, G., Smith, A., Berger, S., Fisher, L.J., and Gage, F.H. Petit Mal epilepsy and Parkinsonian tremor: Hypothesis
of a common pacemaker. Neuroscience, 36(1): 1-14, 1990.
131. Barnett, J., Baecker, P., Routledge-Ward, C., Bursztyn-Pettegrew, H., Chow, J., Nguyen, B., Bach, C., Chan, H.,
Tuszynski, M.H., Yoshida, K., Rubalcava, R., and Gage, F.H. Human ß nerve growth factor obtained from a
baculovirus expression system has potent in vitro and in vivo neurotrophic activity. Experimental Neurology, 110: 1124, 1990.
130. Wolff, J.A., Fisher, L.J., Xy, L., Jinnah, H.A., Langlais, P.J., Iuvone, P.M., O'Malley, K.L., Rosenberg, M.B., Shimohama,
S., Friedmann, T., and Gage, F.H. Grafting fibroblasts genetically modified to produce L-dopa in a rat model of
Parkinson disease. Proceedings of the National Academy of Sciences, USA 86:9011-9014, 1989.
129. Tuszynski, M.H., Jinnah, H..A., and Gage, F.H. Delivery of neuroactive compounds to the brain: potential utility of
genetically modified cells. Neurobiology of Aging,10:644-645, 1989.
128. Shimohama, S., Rosenberg, M.B., Fagan, A.M., Wolff, J.A., Short, M.P., Breakefield, X.P., Friedmann, T., and Gage, F.H.
Grafting genetically modified cells into the rat brain: Characteristics of E.coli ß-galactosidase as a reporter gene.
Molecular Brain Research, 5: 271-278, 1989.
127. Shapiro, M.L., Simon, D.K., Olton, D.S., Gage, F.H., Nilsson, O., and Bjorklund, A. Intrahippocampal grafts of fetal basal
forebrain tissue alter place fields in the hippocampus of rats with fimbria-fornix lesions. Neuroscience, 32: 1-19, 1989.
126. Phelps, C.H., Gage, F.H., Growdon, J.H., Hefti, F., Harbaugh, R., Johnston, M.V., Khachaturian, Z.S., Mobley, W.C.,
Price, D.L., Raskind, M., Simpkins, J., Thal, L.J., and Woodcock, J. Potential use of nerve growth factor to treat
Alzheimer's Disease. Neurobiology of Aging, 10:205-207, 1989.
125. Nilsson, O.G., Gage, F.H., and Bjorklund, A. Central cholinergic blockade produces severe impairments in a spatial
memory task in aged and septal lesioned rats. Neurobiology of Aging, in press, 1989.
124. Mandel, R.J., Gage, F.H., and Thal, L.J. Spatial learning in rats: Correlation with cortical choline acetyltransferase and
improvement with NGF following NBM damage. Experimental Neurology, 104: 208-217, 1989.
123. Mandel, R.J., Gage, F.H., and Thal, L.J. Enhanced detection of nucleus basalis magnocellularis lesion-induced spatial
learning deficit in rats by modification of training regimen, Behavioral Neuroscience, 31:221-229, 1989.
122. Higgins, G.A., Koh, S., Chen, K.S., and Gage, F.H. Nerve growth factor (NGF) induction of NGF receptor gene
expression and cholinergic neuronal hypertrophy within the basal forebrain of the adult rat. Neuron, 3:247-256, 1989.
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121. Gage, F.H., Dunnett, S.B., and Bjorklund, A. Age-related impairments in spatial memory are independent of those in
sensorimotor skills. Neurobiology of Aging, 10(4) 347-352, 1989.
120. Gage, F.H., Batchelor, P., Chen, K.S., Chin, D., Higgins, G.A., Koh, S., Deputy, S., Rosenberg, M.B., Fischer, W., and
Bjorklund, A. NGF receptor re-expression and NGF mediated cholinergic neuronal hypertrophy in the damaged adult
neostriatum. Neuron, 2:1177-1184, 1989.
119. Foster, G.A., Roberts, M.H.T., Wilkinson, L.S., Gage, F.H., Hokfelt, T., Schultzberg, M., and Sharp, T. Structural and
functional analysis of raphe neurone implants into denervated rat spinal cord. Brain Research Bulletin, 22(1): 131-137,
1989.
118. Fischer, W., Gage, F.H., and Bjorklund, A. Degenerative changes in forebrain cholinergic nuclei correlate with cognitive
impairments in aged rats. European Journal of Neuroscience, 1(1):34-45, 1989.
117. Dawson, V.L., Gage, F.H., Hunt, M.A., and Wamsley, J.K. Normalization of subtype specific muscarinic receptor binding
in the denervated hippocampus by septo-diagonal band grafts. Experimental Neurology, 106:115-124, 1989.
116. Chen, K.S., Tuszynski, M.H., and Gage, F.H. Role of neurotrophic factors in Alzheimer's disease. Neurobiology of Aging,
10:545-546, 1989.
115. Buzsaki, G., Wiesner, J., Henriksen, S.J., and Gage, F.H. Long-term potentiation of evoked and spontaneous neuronal
activity in the grafted hippocampus. Experimental Brain Research, 76: 401-408, 1989.
114. Buzsaki, G., Ponomareff, G.L., Bayardo, F., Ruiz, R., and Gage, F.H. Neuronal activity in the subcortically denervated
hippocampus: A chronic model for epilepsy. Neuroscience, 28(3):527-538, 1989.
113. Buzsaki, G. and Gage, F.H. Absence of long-term potentiation in the subcortically deafferented dentate gyrus. Brain
Research, 484: 94-101, 1989.
112. Buzsaki, G., Bayardo, F., Miles, R., Wong, K.S., and Gage, F.H. The Grafted Hippocampus: An Epileptic Focus.
Experimental Neurology, 105:10-22, 1989.
111. Batchelor, P.E., Armstrong, D.M., Blaker, S.N., and Gage, F.H. Nerve growth factor receptor and choline
acetyltransferase colocalization in neurons within the rat forebrain: Response to fimbria-fornix transection. Journal of
Comparative Neurology, 284:187-204, 1989.
110. Rosenberg, M.B., Friedmann, T., Robertson, R.C., Tuszynski, M., Wolff, J.A., Breakefield, X.O., and Gage, F.H. Grafting
of genetically modified cells to the damaged brain: Restorative effects of NGF gene expression. Science, 242: 15751578, 1988.
109. Gage, F.H., Olejniczak, P., and Armstrong, D.M. Astrocytes are important for sprouting in the septohippocampal circuit.
Experimental Neurology, 102: 2-13, 1988.
108. Gage, F.H., Chen, K.S., Buzsaki, G., and Armstrong, D. Experimental approaches to age related cognitive impairments.
Neurobiology of Aging, 9: 645-655, 1988.
107. Gage, F.H., Blaker, S.N., Davis, G.E., Engvall, E., Varon, S., and Manthorpe, M. Human amnion membrane matrix as a
substratum for axonal regeneration in the central nervous system, Experimental Brain Research, 72: 371-380, 1988.
106. Gage, F.H., Armstrong, D.M., Williams, L.R., and Varon, S. Morphological response of axotomized septal neurons to
nerve growth factor. Journal of Comparative Neurology, 269: 147-155,1988.
105. Foster, G.A., Schultzberg, M., Gage, F.H., Bjorklund, A., Hokfelt, T., Cuello, A.C., Verhofstad, A.A.J., Visser, T.J., and
Emson, P.C. Transmitter expression and morphological development of embryonic medullary and mesencephalic
raphe neurones after transplantation to the adult rat central nervous system. III. Grafts to the striatum. Experimental
Brain Research, 70: 242-255, 1988.
104. Foster, G.A., Schultzberg, M., Gage, F.H., Bjorklund, A., Hokfelt, T., Cuello, A.C., Verhofstad, A.A.J., and Visser, T.J.
Transmitter expression and morphological development of embryonic medullary and mesencephalic raphe neurones
after transplantation to the adult rat central nervous system. II. Grafts to the striatum. Experimental Brain Research,
70:225-241, 1988.
103. Buzsaki, G., Ponomareff, G., Bayardo, F., Shaw, T., and Gage, F.H. Suppression and induction of epileptic activity by
neuronal grafts. Proceedings of the National Academy of Sciences, 85:9327-9330, 1988.
102. Buzsaki, G., Bickford, R.G., Ponomareff, G., Thal, L.J., Mandel, R., and Gage, F.H. Nucleus basalis and thalamic control
of neocortical electrical activity in the freely moving rat. Journal of Neuroscience, 8(11): 4007-4027, 1988.
101. Buzsaki, G., Bickford, R.G., Armstrong, D.M., Ponomareff, G., Chen, K.S., Ruiz, R., Thal, L.J., Gage, F.H. Electric activity
in the neocortex of freely moving young and aged rats. Neuroscience, 26(3): 735-745, 1988.
100. Blaker, S.N., Armstrong, D.M., and Gage, F.H. Cholinergic neurons within the rat hippocampus: Response to fimbriafornix transection. Journal of Comparative Neurology, 272:127-138, 1988.
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99. Armstrong, D.M., Hersh, L.B., and Gage, F.H. Morphologic alterations of cholinergic processes in the neocortex of aged
rats. Neurobiology of Aging, 9:199-205, 1988.
98. Williams, L.R., Vahlsing, H.L., Lindamood, T., Varon, S., Gage, F.H., and Manthorpe, M. A small gauge cannula device
for continuous infusion of exogenous agents into the brain. Experimental Neurology, 95:743-745, 1987.
97. Shults, C.W., Johnston, P., and Gage, F.H. Comparison of substance K-like and substance P-like fibers and cells in the
rat hippocampus. Brain Research, 426:290-296, 1987.
96. Peterson, G.M., Williams, L.R., Varon, S., and Gage, F.H. Loss of GABAergic neurons in medial septum after fimbriafornix transection. Neuroscience Letters, 76:140-144, 1987.
95. Nilsson, O.B., Shapiro, M.L., Gage, F.H., Olton, D.S., and Bjorklund, A. Spatial learning and memory following fimbriafornix transection and grafting of fetal septal neurons to the hippocampus. Experimental Brain Research, 67:195-215,
1987.
94. Kesslak, J.P., Frederickson, C.J., and Gage, F.H. Quantification of hippocampal noradrenaline and zinc changes after
selective cell destruction. Experimental Brain Research, 67:77-84, 1987.
93. Gage, F.H., Wolff, J.A., Rosenberg, M.B., Xu, L., Yee, J.-K., Shults, C., and Friedmann, T. Grafting genetically modified
cells to the brain: Possibilities for the future. Neuroscience, 23(3): 795-807, 1987.
92. Fischer, W., Wictorin, K., Bjorklund, A., Williams, L.R., Varon, S. and Gage, F.H. Amelioration of cholinergic neuron
atrophy and spatial memory impairment in aged rats by nerve growth factor. Nature, 329:65-68, 1987.
91. Dawbarn, D., Isacson, O., Brundin, P., Gage, F.H., Emson, P.C., and Bjorklund, A. Striatal grafts in the ibotenic acid
lesioned striatum: Striosomal organization as revealed by immunocytochemistry and receptor autoradiography.
Neuroscience, 22(2):481-497, 1987.
90. Davis, G.E., Blaker, S.N., Engvall, E., Varon, S., Manthorpe, M., and Gage, F.H. Human amnion membrane serves as a
substratum for growing axons in vitro and in vivo. Science, 236:1106-1108, 1987.
89. Buzsaki, G., Gage, F.H., Kellenyi, L. and Bjorklund, A. Behavioral dependence of the electrical activity of intracerebrally
transplanted fetal hippocampus. Brain Research, 400:321-333, 1987.
88. Buzsaki, G., Gage, F.H., Czorpf, J. and Bjorklund, A. Restoration of rhythmic slow activity (theta) in the subcortically
denervated hippocampus by fetal CNS transplants. Brain Research, 400:334-347, 1987.
87. Buzsaki, G., Czopf, J., Kondakor, I., Bjorklund, A., and Gage, F.H. Cellular activity of intracerebrally transplanted fetal
hippocampus during behavior. Neuroscience, 22(3):871-883, 1987.
86. Armstrong, D.M., Terry, R.D., DeTeresa, R.M., Bruce, G., Hersh, L.B., and Gage, F.H. Response of septal cholinergic
neurons to axotomy. The Journal of Comparative Neurology, 264:421-436, 1987.
85. Armstrong, D.M., Bruce, G., Hersh, L.B., and Gage, F.H. Ontogeny of cholinergic neurons in the septal/ diagonal band
complex of the rat. Developmental Brain Research, 36:249-256, 1987.
84. Armstrong, D.M., Bruce, G., Hersh, L.B., and Gage, F.H. Development of cholinergic neurons in the septal/diagonal band
complex of the rat. Developmental Brain Research, 36: 249-256, 1987.
83. Zetterstrom, T., Brundin, P., Gage, F.H., Sharp, T., Isacson, O., Dunnett, S.B., Ungerstedt, U., and Bjorklund, A. In Vivo
measurement of spontaneous release and metabolism of dopamine from intrastriatal nigral grafts using intracerebral
dialysis. Brain Research, 362:344-349, 1986.
82. Williams, L.R., Varon, S., Peterson, G.M., Wictorin, K., Fischer, W., Bjorklund, A. and Gage, F.H. Continuous infusion of
nerve growth factor prevents basal forebrain neuronal death after fimbria-fornix transection. Proceedings of the
National Academy of Science, 83:9231-9235, 1986.
81. Lindvall, O., Ingvar, M, and Gage, F.H. Short term status epilepticus in rats causes specific behavioral impairments
related to substantia nigra necrosis. Experimental Brain Research, 64:143-148, 1986.
80. Kesslak, J.P., and Gage, F.H. Recovery of spatial alternation deficits following selective hippocampal destruction with
kainic acid. Behavioral Neuroscience,100(2):280-283, 1986.
79. Gage, F.H., Wictorin, K., Fischer, W., Williams, L.R., Varon, S. and Bjorklund, A. Retrograde cell changes in medial
septum and diagonal band following fimbria-fornix transection: Quantitative temporal analysis. Neuroscience,
19(1):241-255, 1986.
78. Gage, F.H., and Bjorklund, A. Enhanced graft survival in the hippocampus following selective denervation.
Neuroscience, 17(1):89-98, 1986.
77. Gage, F.H. and Bjorklund, A. Cholinergic septal grafts into the hippocampal formation improve spatial learning and
memory in aged rats by an atropine-sensitive mechanism. Journal of Neuroscience, 6(10): 2837-2847, 1986.
76. Foster, G.A., Schultzberg, M., Gage, F.H., Bjorklund, A., Hokfelt, T., Cuello, A.C., Verhofstad, A.A.J., and Visser, T.J.
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Clarke, D.J., Gage, F.H., Nilsson, O.G. and Bjorklund, A. Grafted septal neurons from cholinergic synaptic connections in
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Brundin, P., Isacson, O., Gage, F.H., Prochiantz, A., and Bjorklund, A. The rotating 6-hydroxydopamine-lesioned mouse
as a model for assessing functional of neuronal grafting. Brain Research, 346-349, 1986.
Brundin, P., Isacson, O., Gage, F.H., and Bjorklund, A. Intrastriatal grafting of dopamine-containing neuronal cell
suspensions: Effects of mixing with target and non-target cells. Developmental Brain Research, 24:77-84, l986.
Bjorklund, A., Nornes, H., and Gage, F.H. Cell suspension grafts of noradrenergic locus coeruleus neurons in rat
hippocampus and spinal cord: Reinnervation and transmitter turnover. Neuroscience, 18(3): 685-698,1986.
Acsadi, G., Buzsaki, G., Keszthelyi, T., Kiralyfalvi, L. and Gage, F.H. Effects of confinement, previous experience and
hippocampal damage on the DRL schedule. Behavioral Brain Research, 20:241-248, 1986.
Wieloch, T., Lindvall, O., Bloomquist, P., and Gage, F.H. Evidence for amelioration of ischemic neuronal damage in the
hippocampal formation by lesions of the perforant path. Neurology Research,7:24-26, 1985.
Segal, M., Bjorklund, A., and Gage, F.H. Transplanted septal neurons make viable cholinergic synapses with a host
hippocampus. Brain Research, 336:302-307, 1985.
Schultzberg, M., Foster, G.A., Gage, F.H., Bjorklund, A., and Hokfelt. The transmitter phenotypy and nerve fibre
outgrowth of peptide neurones in coexistence systems studied in intracerebral transplants. Acta Physiol. Scand.,
124:542, 1985.
Kelly, P.A.T., Gage, F.H., Ingvar, M., Lindvall, O., Stenevi, U., and Bjorklund, A. Functional reactivation of the
deafferented hippocampus by embryonic septal grafts as assessed by measurements of local glucose utilization.
Experimental Brain Research, 58:570-579,1985.
Isacson, O., Brundin, P., Gage, F.H., and Bjorklund, A. Neural grafting in a rat model of Huntington's Disease:
Progressive neurochemical changes after neostriatal ibotenate lesions and striatal tissue grafting. Neuroscience,
14(4):799-817, 1985.
Gage, F.H., Stenevi, U., Carlstedt, T., Foster, G., Bjorklund, A., and Aguayo, A.J. Anatomical and functional
consequences of grafting mesencephalic neurons into a peripheral nerve "bridge" connected to the denervated
stratium. Experimental Brain Research, 60:584-589, l985.
Gage, F.H., Brundin, P., Isacson, O., and Bjorklund, A. Rat fetal brain tissue grafts survive and innervate host brain
following five day pregraft tissue storage. Neuroscience Letters, 60:133-137, 1985.
Foster, G.A., Schultzberg, M., Gage, F.H., Bjorklund, A., Hokfelt, T., Nornes, H., Cuello, A.C., Verhofstad, A.A.J., and
Visser, T.J. Transmitter expression and morphological development of embryonic medullary and mesencephalic raphe
neurones after transplantation to the adult rat central nervous system. Experimental Brain Research, 60:427-444,
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Clarke, D.J., Gage, F.H., and Bjorklund, A. Formation of cholinergic synapses by intrahippo-campal septal grafts as
revealed by acetyltransferase immunocytochemistry. Brain Research, 369:151-162, l985.
Brundin, P., Nilsson, O.G., Gage, F.H., and Bjorklund, A. Cyclosporin A increases survival of cross-species intrastriatal
grafts of embryonic dopamine-containing neurons. Experimental Brain Research, 60:204-208, l985.
Brundin, P., Barbin, G., Isacson, O., Mallat, M., Chamak, B., Prochiantz, A, Gage, F.H. and Bjorklund, A. Survival of
intracerebrally grafted rat dopamine neurons previously cultured in vitro. Neuroscience Letters, 61:79-84, 1985.
Bengtsson, F., Gage, F.H., Jeppson, B., Nobin, A., and Rosengren, E. Brain monoamine metabolism and behavior in
portacaval shunted rats. Experimental Neurology, 90:21-35, 1985.
Gage, F.H., and Bjorklund, A. Intracerebral grafting of neuronal cell suspensions into the adult brain. Central Nervous
System Trauma, 1:47-56, 1984.
Isacson, O., Brundin, B., Kelly, P.A.T., Gage, F.H., and Bjorklund, A. Functional neural replacement by grafted striatal
neurons in the ibotenic acid lesioned rat striatum. Nature, 311:458-460, 1984.
Dunnett, S.B., Bunch, S.T., Gage, F.H., and Bjorklund, A. Dopamine-rich transplants in rats with 6-OHDA lesions of the
ventral segmental area: I. Effects on spontaneous and drug-induced locomotor activity. Behavioral Brain Research,
13:71-82, 1984.
Gage, F.H., Kelly, P.A.T., and Bjorklund, A. Regional changes in brain glucose metabolism reflect cognitive impairments
in aged rats. The Journal of Neuroscience, 4(ll):2856-2866, 1984.
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Gage, F.H., Bjorklund, A., Stenevi, U., Dunnett, S.B., and Kelly, P.A.T. Intrahippocampal septal grafts ameliorate learning
impairments in aged rats. Science, 225:533-536, 1984.
Gage, F.H., Bjorklund, A., and Stenevi, U. A neuronal survival factor in the adult hippo-campal formation is released by
denervation. Nature, 308:637-639, 1984.
Evans, S.H., Chafetz, M.D., and Gage, F.H. Taxonomic abstractions in psychobiology, Journal of General Psychology,
111:209-227, 1984.
Gage, F.H., Dunnett, S.B., and Bjorklund, A. Spatial learning and motor deficits in aged rats. Neurobiology of Aging, 5:4348, 1984.
Barker, D.J., Howard, A.J., and Gage, F.H. Functional significance of sympathohippocampal sprouting: changes in single
cell spontaneous activity. Brain Research, 291:357-363, 1984.
Gage, F.H., Bjorklund, A., and Stenevi, U. Cells of origin of the ventral cholinergic septohippocampal pathway undergoing
compensatory collateral sprouting following fimbria-fornix transection. Neuroscience Letters, 44:211-216, 1984.
Stewart, G.R., Frederickson, C.J., Howell, G.A., and Gage, F.H. Cholinergic denervation-induced increase of chelatable
zinc in mossy-fiber region of the hippocampal formation. Brain Research, 290:43-51, 1984.
Whipple, M.R., Reinecke, M.G., and Gage, F.H. Inhibition of synaptosomal neurotransmitter uptake by hallucinogens.
Journal of Neurochemistry, 40(4):1185-1188, 1983.
Schmidt, R.H., Bjorklund, A., Stenevi, U., Dunnett, S.B., and Gage, F.H. Intracerebral Grafting of Neuronal Cell
Suspensions: III. Activity of intrastriatal nigral suspension implants as assessed by measurements of dopamine
synthesis and metabolism. Acta Physiol. Scand., Suppl. 522, 19-28, 1983.
Gage, F.H., Dunnett, S.B., Stenevi, U., and Bjorklund, A. Intracerebral Grafting of Neuronal Cell Suspensions: VIII.
Survival and growth of implants of nigral and septal cell suspensions in intact brains of aged rats. Acta Physiol.
Scand., Suppl. 522, 67-75, 1983.
Gage, F.H., Dunnett, S.B., Stenevi, U. and Bjorklund, A. Aged rats: Recovery of motor impair-ments by intrastriatal nigral
grafts. Science, 221:819-822, 1983.
Gage, F. H., Bjorklund, A., and Stenevi, U. Reinnervation of the partially deafferented hippocampus by compensatory
collateral sprouting from spared cholinergic and adrenergic afferents. Brain Research, 268(l):27-37, 1983.
Gage, F.H., Bjorklund, A., and Stenevi, U. Local regulation of compensatory noradrenergic hyperactivity in the partially
denervated hippocampus. Nature, 303:819-82l, 1983.
Gage, F.H., Bjorklund, A., Stenevi, U., and Dunnett, S.B. Functional correlates of compensatory sprouting by biogenic
amine and cholinergic afferents in the hippocampal formation. Brain Research, 268(l):27-38, 1983.
Chafetz, M.D., and Gage, F.H. Pineal and habenula innervation altered by septal lesions. Brain Research Bulletin, 10:2731, 1983.
Bjorklund, A., Stenevi, U., Schmidt, R.H., Dunnett, S.B., and Gage, F.H. Intracerebral Grafting of Neuronal Cell
Suspensions: II. Survival and growth of nigral cell suspensions implanted in different brain sites. Acta Physiol. Scand.,
Suppl. 552, 9-18, 1983.
Bjorklund, A., Stenevi, U., Schmidt, R.H., Dunnett, S.B., and Gage, F.H. Intracerebral Grafting of Neuronal Cell
Suspensions: I. Introduction and general methods of preparation. Acta Physiol. Scand., Suppl. 522, 1-7,1983.
Bjorklund, A., Gage, F.H., Stenevi, U., and Dunnett, S.B. Intracerebral Grafting of Neuronal Cell Suspensions: VI.
Survival and growth of intrahippocampal implants of septal cell suspensions. Acta Physiol. Scand., Suppl. 522, 49-58,
1983.
Bjorklund, A., Gage, F.H., Schmidt, R.H., Stenevi, U., and Dunnett, S.B. Intracerebral Grafting of Neuronal Cell
Suspensions: VII. Recovery of choline acetyltransferase activity and acetylcholine synthesis in the denervated
hippocampus reinnervated by septal suspension implants. Acta Physiol. Scand., Suppl. 522, 59-66,1983.
Turner, F.D., and Gage, F.H. Measurement in psychobiology: Dynamics of the unconditioned response. Physiology and
Behavior, 29:957-960, 1982.
Chafetz, M.D., and Gage, F.H. Fluorescence measurements of lesion-induced fiber growth. I. Microfluoro-metric
technique to measure density and intensity of varicosities and fibers. Brain Research, 247(2):209-216, 1982.
Chafetz, M.D., Evans, S., and Gage, F.H. Recovery of function from septal damage and the growth of
sympathohippocampal fibers. Physiological Psychology, 10(4):39l-398, 1982.
Chafetz, M.D., Evans, S.H., and Gage, F.H. Fluorescence measurements of lesion-induced fiber growth.
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II. Fluorescence measurements of sympatho-hippocampal sprouting using a new microfluorometric method. Brain
Research, 247(2):217-226, 1982.
Bjorklund, A., Stenevi, U., Dunnett, S.B., and Gage, F.H. Cross-species neural grafting in a rat model of Parkinson's
disease. Nature, 298:652-654, 1982.
Thompson, R.G., Valdes, J.J., and Gage, F.H. Reversible alterations in hypothalamic uptake of biogenic amines after
septal lesions. Experimental Neurology, 74:359-369, 1981.
Gage, F.H., and Springer, J. Behavioral assessment of norepinephrine and serotonin function and interaction in the
hippocampal formation. Pharmacology, Biochemistry, and Behavior, 14:8l5-821, 1981.
Gage, F.H., and Evans, S.H. Exploratory analysis of deficits in DRL performance induced by medial and lateral fornix
damage. Physiological Psychology, 9(l):49-53, 1981.
Evans, S.H., Neideffer, J.D., and Gage, F.H. APL functions for interactive data analysis: Principal components analysis.
Behavior Research Methods and Instrumentation, 74:356-369, 1981.
Chafetz, M.D., Thompson, R.G., and Gage, F. H. Biochemical specificity of septal hyperreactivity:
A behavioral discrimination. Behavioral Brain Research, 2:409-420, 1981.
Valdes, J.J., Cameron, W.R., Evans, S.H., and Gage, F.H. Regional brain morphine injections selectively attentuate
aspects of septal hyperreactivity: A multivariate assessment. Pharmacology, Biochemistry, and Behavior, 12:563-572,
1980.
Gage, F.H., Valdes, J.J., and Thompson, R.G. Morphine injections into the periaqueductal-periventricular gray attenuate
septal hyperreactivity. Psychopharmacology. 70:113-114, 1980.
Gage, F.H. and Thompson, R.G. Differential distribution of norepinephrine and serotonin along the dorsal-ventral axis of
the hippocampal formation. Brain Research Bulletin, 5:771-773, 1980.
Gage, F.H., Armstrong, D.R., and Thompson, R.G. A method to derive qualitative and quantitative changes in sensory
responsiveness following septal nuclei damage. Physiology and Behavior, 24:479-484, 1980.
Evans, S.H., Neideffer, J.D., and Gage, F.H. APL functions for interactive data analysis: Graphics and labels. Behavior
Research Methods and Instrumentation, 12:541-545, 1980.
Evans, S.H.,and Gage, F.H. APL programs for interactive data analysis: Correlations and data entry. Behavior Research
Methods and Instrumentation, 12(3):372-375, 1980.
Gage, F.H., Evans, S.H., and Olton, D.S. A multivariate approach to the analysis of differential reinforcement of low rates
of responding (DRL) paradigm. Animal Behavior and Learning, 7(3):323-327, 1979.
Evans, S.H., and Gage, F.H. APL programs for interactive data analysis: Basic statistics and histograms. Behavior
Research Methods and Instrumentation, 6:605-606, 1979.
Cameron, W.R., Gage, F.H., Hitt, J.C., and Poplow, H.B. The influence of the anteriodorsal hippocampus on feminine
sexual behavior in rats. Behavioral and Neural Biology, 7:72-86, 1979.
Babitch, J.S., Gage F.H., and Valdes, J.J. Evidence that actin is involved in neurotransmitter release. Life Sciences,
24:117-123, 1979.
Olton, D.S., Walker, J.A., and Gage, F.H. Hippocampal connections and spatial discriminations. Brain Research,
139:295-308, 1978.
Gage, F.H., Thompson, R.C., and Valdes, J.J. Endogenous norepinephrine and serotonin in regions of the hippocampus
during development of and recovery from septal hyperreactivity. Pharmacology, Biochemistry, and Behavior, 9:359362, 1978.
Gage. F.J., Olton, D.S., and Murphy, C. Septal hyperreactivity: A multivariate analysis of neuroanatomical correlates.
Physiological Psychology, 6(3):314-318, 1978.
Gage, F.H., Olton, D.S., and Bolanowski, A. Activity, reactivity and dominance following septal lesions in rats. Behavioral
Biology, 22:203-210, 1978.
Gage, F.H., and Lieberman, A.F. A multivariate analysis of social dominance in children. Aggressive Behavior, 4(3):219230, 1978.
Gage, F.H. A multivariate approach to the analysis of social dominance. Behavioral Biology, 23:38-57, 1978.
Olton, D. S., Walker, J.A., Gage, F.H., and Johnson, C.T. Choice behavior of rats searching for food. Learning and
Motivation, 8:315-331, 1977.
Johnson, C.T., Olton, D.S., Gage, F.H., and Jenko, P. Damage to hippocampus and hippocampal connections: Effects
on DRL and spontaneous alternation. Journal of Comparative and Physiological Psychology, 91:508-522, 1977.
Jenko, P., Gage, F.H., and Olton, D.S. Time-dependent fornix influence on increased light aversion induced by septal
lesions. Physiology and Behavior, l7:607-6l4, 1976.
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Gage, F.H., and Olton, D.S. Attenuation of septal hyper-reactivity following L-Dopa injections. Behavioral Biology,
l7:2l3-2l8, 1976.
Gage, F.H., and Olton, D.S. Hippocampal influence in the septal syndrome. Brain Research, 98:311-325, 1975.
Olton, D.S., and Gage, F.H. Role of the fornix in the septal syndrome. Physiology and Behavior, 13:269-279, 1974.
Woodruff, M.L., Gage, F.H., and Isaacson, R.L. Changes in focal epileptic activity produced by brain stem sections in the
rabbit. Electroencephalography and Clinical Neurophysiology, 35:475-486, 1973.
Isaacson, R.L., and Gage, F. H. Hypothalamic stimulation and the persistence of epileptiform discharges. Brain Research,
49:194-199, 1973.
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