KAEMPFEROL
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
LK9275200
Flavone, 3,4',5,7-tetrahydroxy520-18-3
0304401
5-18-05-00251 (Beilstein Handbook Reference)
199612
14
C15-H10-O6
286.25
T66 BO EVJ CR DQ& DQ GQ IQ
Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* 4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-(4-hydroxyphenyl)* Campherol
* C.I. 75640
* Indigo Yellow
* Kaempferol
* Kaempherol
* Kampherol
* Kempferol
* Nimbecetin
* Pelargidenolon
* Pelargidenolon 1497
* Populnetin
* Rhamnolutein
* Rhamnolutin
* Robigenin
* Swartziol
* 3,4',5,7-Tetrahydroxyflavone
* Trifolitin
* 5,7,4'-Trihydroxyflavonol
*** HEALTH HAZARD DATA ***
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 166 nmol/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
54,297,1978
TYPE OF TEST
: DNA adduct
TEST SYSTEM
: Bacteria - Escherichia coli
DOSE/DURATION
: 100 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
89,95,1981
TYPE OF TEST
: Micronucleus test
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 10 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
246,205,1991
TYPE OF TEST
: DNA inhibition
TEST SYSTEM
: Human Fibroblast
DOSE/DURATION
: 50 mg/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11958Volume(issue)/page/year:
33,3823,1984
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Human Fibroblast
DOSE/DURATION
: 100 mg/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11958Volume(issue)/page/year:
33,3823,1984
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 20 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
246,205,1991
TYPE OF TEST
: Sex chromosome loss and nondisjunction
TEST SYSTEM
: Human Lymphocyte
DOSE/DURATION
: 20 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
246,205,1991
TYPE OF TEST
: Micronucleus test
ROUTE OF EXPOSURE
: Intraperitoneal
TEST SYSTEM
: Rodent - mouse
DOSE/DURATION
: 200 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
89,69,1981
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 25 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
113,45,1983
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 45 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
113,45,1983
TYPE OF TEST
: Mutation in mammalian somatic cells
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 25 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
113,45,1983
*** REVIEWS ***
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 31,171,1983
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 31,171,1983
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,56,1987
KALLIKREIN
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
COMPOUND DESCRIPTOR
SYNONYMS/TRADE NAMES :
* Bradykini
* Callicrein
:
:
:
:
:
:
NZ2017050
Kallikrein
9001-01-8
199801
8
Drug
Mutagen
Reproductive Effector
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
Depot-padutin
Dilminal D
E.C. 3.4.4.21
E.C. 3.4.21.8
Glumorin
Kallidinogenase
Kininogenase
Kininogenin
Onokrein P
Padreatin
Padutin
Pancreatic kallikrein
SK-827
Urinary kallikrein
Urokallikrein
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >40 mL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.11960Volume(issue)/page/year: 27,2589,1993
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >40 mL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.11960Volume(issue)/page/year: 27,2589,1993
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >40 mL/kg
TOXIC EFFECTS :
Kidney, Ureter, Bladder - urine volume increased
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.11960Volume(issue)/page/year: 27,2589,1993
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Oral
Rodent - mouse
>40 mL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.11960Volume(issue)/page/year: 27,2589,1993
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >40 mL/kg
TOXIC EFFECTS :
Nutritional and Gross Metabolic - other changes
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.11960Volume(issue)/page/year: 27,2589,1993
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: >40 mL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.11960Volume(issue)/page/year: 27,2589,1993
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 210 ku/kg
SEX/DURATION
: female 19-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - parturition
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book
Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.11960Volume(issue)/page/year: 47,319,1976
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Inconclusive: Sperm morphology-human
KANAMYCIN MONOSULFATE
RTECS NUMBER
CHEMICAL NAME
: NZ3225030
: Kanamycin, sulfate (1:1) (salt)
CAS REGISTRY NUMBER
: 25389-94-0
OTHER CAS REGISTRY NOS. : 133-92-6
11030-21-0
LAST UPDATED
: 199707
DATA ITEMS CITED
: 30
MOLECULAR FORMULA
: C18-H36-N4-O11.H2-O4-S
MOLECULAR WEIGHT
: 582.66
WISWESSER LINE NOTATION : T6OTJ B1Z CQ DQ EQ FO- BL6TJ AZ CQ EZ DO- BT6OTJ
CQ
DZ EQ F1Q &..H2.S-O4
COMPOUND DESCRIPTOR
: Drug
Reproductive Effector
Human
Natural Product
SYNONYMS/TRADE NAMES :
* Cantrex
* Cristalomicina
* Kamycin
* Kamynex
* Kanabristol
* Kanacedin
* Kanamycin A sulfate
* Kanamycin monosulfate
* Kanamycin sulfate (1:1) (salt)
* Kanamytrex
* Kanaqua
* Kanasig
* Kanatrol
* Kanescin
* Kanicin
* Kannasyn
* KANO
* Kantrex
* Kantrexil
* Kantrox
* Klebcil
* Ophtalmokalixan
* Otokalixin
* Resistomycin (bayer)
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Human - child
DOSE/DURATION
: 390 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Ear) - change in acuity
REFERENCE :
JOPDAB Journal of Pediatrics. (C.V. Mosby Co., 11830 Westline Industrial
Dr., St. Louis, MO 63141) V.11932- Volume(issue)/page/year:
60,230,1962
TYPE OF TEST
ROUTE OF EXPOSURE
: LD50 - Lethal dose, 50 percent kill
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research
Assoc.,
2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.211968Volume(issue)/page/year: 28,415,1975
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 3200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research
Assoc.,
2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.211968Volume(issue)/page/year: 28,415,1975
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.11951Volume(issue)/page/year: 12,597,1962
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 225 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research
Assoc.,
2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.211968Volume(issue)/page/year: 28,415,1975
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research
Assoc.,
2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.211968Volume(issue)/page/year: 28,415,1975
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 17500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,173,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1353 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AACHAX Antimicrobial Agents and Chemotherapy (1961-70). (Ann Arbor, MI)
1961-70. For publisher information, see AMACCQ.
Volume(issue)/page/year:
-,138,1963
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1100 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
Lungs, Thorax, or Respiration - other changes
Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher
information, see AMBIEH. Volume(issue)/page/year: 29,851,1984
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 240 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,173,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1190 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,173,1982
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
: LD50 - Lethal dose, 50 percent kill
: Oral
: Rodent - rabbit
DOSE/DURATION
: >3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research
Assoc.,
2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.211968Volume(issue)/page/year: 28,415,1975
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research
Assoc.,
2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.211968Volume(issue)/page/year: 28,415,1975
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 550 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research
Assoc.,
2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.211968Volume(issue)/page/year: 28,415,1975
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research
Assoc.,
2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.211968Volume(issue)/page/year: 28,415,1975
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
Kidney, Ureter,
Kidney, Ureter,
Nutritional and
REFERENCE :
JJANAX Japanese
:
:
:
:
TDLo - Lowest published toxic dose
Subcutaneous
Rodent - rat
12 gm/kg/30D-I
Bladder - changes in both tubules and glomeruli
Bladder - changes in bladder weight
Gross Metabolic - weight loss or decreased weight gain
Journal of Antibiotics.
(Japan Antibiotics Research
Assoc.,
2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan)
Volume(issue)/page/year: 28,415,1975
V.21-
1968-
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 12 gm/kg/20D-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Ear) - changes in cochlear structure or
function
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
50,267,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 4 gm/kg/20D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
Kidney, Ureter, Bladder - other changes in urine composition
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
SASHA5 Sanfujinka no Shinpo. (Sanfujinka no Shinpo Henshu Jimukyoku, c/o
Domeisha Shuppan, 2 Kagita-cho, Chudoji, Shimogyo-ku, Kyoto, 600, Japan)
V.11949- Volume(issue)/page/year: 12,484,1960
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 31200 mg/kg/26W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
Kidney, Ureter, Bladder - other changes
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research
Assoc.,
2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.211968Volume(issue)/page/year: 28,435,1975
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 10400 mg/kg/30D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
Kidney, Ureter, Bladder - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research
Assoc.,
2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.211968Volume(issue)/page/year: 28,458,1975
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 31200 mg/kg/26W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal
failure,
acute tubular necrosis)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research
Assoc.,
2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.211968Volume(issue)/page/year: 28,485,1975
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Mammal - cat
DOSE/DURATION
: 6300 mg/kg/42D-I
TOXIC EFFECTS :
Behavioral - ataxia
REFERENCE :
AACHAX Antimicrobial Agents and Chemotherapy (1961-70). (Ann Arbor, MI)
1961-70. For publisher information, see AMACCQ.
Volume(issue)/page/year:
-,138,1963
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 22222 mg/kg/77D-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Ear) - change in acuity
Sense Organs and Special Senses (Ear) - changes in cochlear structure or
function
Behavioral - muscle contraction or spasticity
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information,
see TOSCF2 Volume(issue)/page/year: 1,395,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 5600 mg/kg/2W-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Ear) - changes in cochlear structure or
function
Behavioral - changes in motor activity (specific assay)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
34,327,1975
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 980 mg/kg
SEX/DURATION
: female 8-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research
Assoc.,
2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.211968Volume(issue)/page/year: 28,372,1975
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - rat
DOSE
: 4400 mg/kg
SEX/DURATION
: female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
SASHA5 Sanfujinka no Shinpo. (Sanfujinka no Shinpo Henshu Jimukyoku, c/o
Domeisha Shuppan, 2 Kagita-cho, Chudoji, Shimogyo-ku, Kyoto, 600, Japan)
V.11949- Volume(issue)/page/year: 12,484,1960
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 980 mg/kg
SEX/DURATION
: female 7-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research
Assoc.,
2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.211968Volume(issue)/page/year: 28,372,1975
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - guinea pig
DOSE
: 3200 mg/kg
SEX/DURATION
: female 55-62 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - eye/ear
REFERENCE :
AORLCG Archives of Oto-Rhino-Laryngology. (Springer-Verlag New York,
Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.2061973Volume(issue)/page/year: 238,45,1983
*** REVIEWS ***
TOXICOLOGY REVIEW
PMMDAE Panminerva Medica. (Edizioni Minerva Medica, Casella Postale 491,
Turin, Italy) V.11959- Volume(issue)/page/year: 16,9,1974
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4729
No. of Facilities: 320 (estimated)
No. of Industries: 2
No. of Occupations: 6
No. of Employees: 11433 (estimated)
No. of Female Employees: 8118 (estimated)
KAOLIN
RTECS NUMBER
:
CHEMICAL NAME
:
CAS REGISTRY NUMBER
:
LAST UPDATED
:
DATA ITEMS CITED
:
COMPOUND DESCRIPTOR
:
SYNONYMS/TRADE NAMES :
* Altowhites
* Argilla
* Bentone
* China clay
* Emathlite
* Fitrol
* Fitrol desiccite 25
* Glomax
* Hydrite
* Kaolin
* Kaopaous
* Kaophills-2
* Langford
* Mcnamee
* Parclay
* Porcelain clay
* Snow tex
GF1670500
Clay (kaolin)
1332-58-7
199712
27
Reproductive Effector
*** HEALTH HAZARD DATA ***
** REPRODUCTIVE DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
590 gm/kg
female 37 day(s) pre-mating
female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
REFERENCE :
JONUAI Journal of Nutrition. (Subscription Dept., 9650 Rockville Pike,
Bethesda, MD 20014) V.11928- Volume(issue)/page/year: 107,2020,1977
*** REVIEWS ***
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 2 mg/m3, respirable dust
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 2 mg/m3, total dust
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD:NUISANCE PARTICULATES
DTLWS* "Documentation of the Threshold Limit Values for Substances in
Workroom Air," Supplements. For publisher information, see 85INA8.
Volume(issue)/page/year: 3,21,1973
OSHA PEL (Gen Indu):8H TWA 15 mg/m3, total dust
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Gen Indu):8H TWA 5 mg/m3, respirable fraction
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 15 mg/m3, total dust
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402)
29,1926.55,1994
Volume(issue)/page/year:
OSHA PEL (Construc):8H TWA 5 mg/m3, respirable fraction
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 15 mg/m3, total dust
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Shipyard):8H TWA 5 mg/m3, respirable fraction
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office,
Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 10 mg/m3 JAN 1993
OEL-BELGIUM:TWA 10 mg/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 10 mg/m3 JAN 1993
OEL-SWITZERLAND:TWA 6 mg/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO KAOLIN, respirable fraction-air:10H TWA 5 mg/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO KAOLIN, total dust-air:10H TWA 10 mg/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 41775
No. of Facilities: 14181 (estimated)
No. of Industries: 111
No. of Occupations: 88
No. of Employees: 155396 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X1959
No. of Facilities: 3 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 17 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X6880
No. of Facilities: 1734 (estimated)
No. of Industries: 23
No. of Occupations: 24
No. of Employees: 25166 (estimated)
No. of Female Employees: 3162 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X9449
No. of Facilities: 7 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 1354 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X9507
No. of Facilities: 62 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 125 (estimated)
NOES - National Occupational
NOES Hazard Code - 41775
No. of Facilities: 43700
No. of Industries: 240
No. of Occupations: 156
No. of Employees: 745593
No. of Female Employees:
Exposure Survey (1983)
(estimated)
(estimated)
114032 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
KEPONE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
: PC8575000
: 1,3,4-Metheno-2H-cyclobuta(cd)pentalen-2-one,
1,1a,3,3a,4,5,5,5a,5b,6-decachloroctahydro: 143-50-0
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
IG
COMPOUND DESCRIPTOR
:
:
:
:
:
199907
63
C10-Cl10-O
490.60
L545 BH C5 D 4ABCE J DVTJ AG BG CG EG FG GG HG HG
JG
: Agricultural Chemical
Tumorigen
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Ciba 8514
* Chlordecone
* Clordecone
* Compound 1189
* 1,2,3,5,6,7,8,9,10,10-Decachloro(5.2.1.0(sup 2,6).0(sup 3,9).0(sup
5,8))decano-4-one
* Decachloroketone
* Decachloro-1,3,4-metheno-2H-cyclobuta(cd)pentalen-2-one
* Decachlorooctahydro-1,3,4-metheno-2H-cyclobuta(cd)pentalen-2-one
*
1,1a,3,3a,4,5,5,5a,5b,6-Decachlorooctahydro-1,3,4-metheno-2H-cyclobuta(c
d)pentalen-2-one
* Decachloropentacyclo(5.2.1.0(sup 2,6).0(sup 3,9).0(sup 5,8))decan-4-one
* Decachloropentacyclo(5.3.0.0(sup 2,6).0(sup 4,10).0(sup
5,9))decan-3-one
* Decachlorotetracyclodecanone
* Decachlorotetrahydro-4,7-methanoindeneone
* ENT 16,391
* GC 1189
* General chemicals 1189
* Kepone
* NCI-C00191
* RCRA waste number U142
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 91300 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY)
V.3-8,
1981-86. For publisher information, see NETEEC. Volume(issue)/page/year:
5,91,1983
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Administration onto the skin
Rodent - rat
>2 gm/kg
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
14,515,1969
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 250 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
45,331,1978
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 65 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCOC** Pesticide Chemicals Official Compendium, Association of the
American
Pesticide Control Officials, Inc., 1966. (Topeka, KS)
Volume(issue)/page/year: -,642,1966
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 345 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information
Canada,
171 Slater St., Ottawa, Ont., Canada) Volume(issue)/page/year: 6,96,1973
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - quail
DOSE/DURATION
: 237 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book
Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.11960Volume(issue)/page/year: 48,371,1976
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LD50 - Lethal dose, 50 percent kill
Unreported
Mammal - species unspecified
126 mg/kg
Details of toxic effects not reported other than lethal dose value
REFERENCE :
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York,
Springer-Verlag
New York, Inc., 1971 Volume(issue)/page/year: -,65,1971
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 307 mg/kg/15W-I
TOXIC EFFECTS :
Behavioral - alteration of operant conditioning
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY)
V.3-8,
1981-86. For publisher information, see NETEEC. Volume(issue)/page/year:
5,91,1983
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 912 mg/kg/2Y-C
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
48,29,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 100 mg/kg/10D-I
TOXIC EFFECTS :
Endocrine - changes in spleen weight
Blood - changes in other cell count (unspecified)
Immunological Including Allergic - decreased immune response
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 15,561,1985
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 162 mg/kg/90D-C
TOXIC EFFECTS :
Biochemical - Neurotransmitters or modulators (putative) - dopamine in
striatum
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.159,262,1981
1959-
Volume(issue)/page/year:
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 287 mg/kg/35D-C
TOXIC EFFECTS :
Liver - other changes
Liver - changes in liver weight
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
58,132,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 75 mg/kg/3D-I
TOXIC EFFECTS :
Behavioral - tremor
Musculoskeletal - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 25,262,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 12500 ug/kg/5D-I
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation,
etc.)
REFERENCE :
PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1
E.
First St., Duluth, MN 55802) V.11971- Volume(issue)/page/year:
18,113,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 180 mg/kg/18D-I
TOXIC EFFECTS :
Behavioral - ataxia
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR
72203) V.11979- Volume(issue)/page/year: 2,113,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 150 mg/kg/3D-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Behavioral - tremor
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
6,275,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 320 mg/kg/10W-I
TOXIC EFFECTS :
Liver - changes in liver weight
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus,
NJ
07094) V.11966- Volume(issue)/page/year: 39,615,1987
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 560 mg/kg/2.5Y-C
TOXIC EFFECTS :
Cardiac - changes in heart weight
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
48,29,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Bird - quail
DOSE/DURATION
: 1470 mg/kg/42D-C
TOXIC EFFECTS :
Liver - changes in liver weight
Related to Chronic Data - death
Related to Chronic Data - changes in testicular weight
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
43,535,1978
** TUMORIGENIC DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
200 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
NEOLA4 Neoplasma. (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland)
V.41957- Volume(issue)/page/year: 26,231,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1200 mg/kg/80W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-b,1976
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 670 mg/kg/80W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-b,1976
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1340 mg/kg/80W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
37,680,1976
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1550 mg/kg/80W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.191958- Volume(issue)/page/year:
37,680,1976
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 504 mg/kg/80W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
Skin and Appendages - tumors
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 4,895,1978
TYPE OF TEST
: TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1344 mg/kg/80W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 4,895,1978
** REPRODUCTIVE DATA **
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
63 mg/kg
female 2-22 day(s) after conception
lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
4,247,1979
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
42 mg/kg
female 2-22 day(s) after conception
lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - other postnatal measures or effects
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
41,142,1977
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
100 mg/kg
female 7-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous
System
Reproductive - Specific Developmental Abnormalities - urogenital system
Reproductive - Specific Developmental Abnormalities - homeostasis
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
38,189,1976
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 60 mg/kg
SEX/DURATION
: female 7-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
38,189,1976
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - rat
17 mg/kg
female 1-22 day(s) after conception
lactating female 12 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for
Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
Volume(issue)/page/year: 40,667,1981
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE
: 18 mg/kg
SEX/DURATION
: male 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora
lutea)
Reproductive - Fertility - litter size (e.g. # fetuses per litter;
measured
before birth)
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
30,237,1986
TYPE OF TEST
ROUTE OF EXPOSURE
: TDLo - Lowest published toxic dose
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 25 mg/kg
SEX/DURATION
: female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects
REFERENCE :
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11987Volume(issue)/page/year:
5,65,1991
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 50 mg/kg
SEX/DURATION
: female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
Reproductive - Fertility - mating performance (e.g. # sperm positive
females
per # females mated; # copulations per # estrus cycles)
Reproductive - Fertility - female fertility index (e.g. # females
pregnant
per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY)
V.3-8,
1981-86. For publisher information, see NETEEC. Volume(issue)/page/year:
8,121,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 50 mg/kg
SEX/DURATION
: female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora
lutea)
REFERENCE :
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11987Volume(issue)/page/year:
1,105,1987/1988
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 75 mg/kg
SEX/DURATION
: female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.11987Volume(issue)/page/year:
5,65,1991
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 2 mg/kg
SEX/DURATION
: female 2 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11967- Volume(issue)/page/year: 16,131,1978
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE
: 10 mg/kg
SEX/DURATION
: female 2 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11967- Volume(issue)/page/year: 16,131,1978
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - mouse
16500 ug/kg
male 4 week(s) pre-mating
female 4 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
JEENAI Journal of Economic Entomology. (Entomological Soc. of America,
4603
Calvert Rd., College Park, MD 20740) V.11908Volume(issue)/page/year:
58,754,1965
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 120 mg/kg
SEX/DURATION
: female 7-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
Reproductive - Specific Developmental Abnormalities - musculoskeletal
system
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
38,189,1976
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE
SEX/DURATION
:
:
:
:
:
TDLo - Lowest published toxic dose
Oral
Rodent - mouse
100 mg/kg
female 8-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - live birth index (measured after
birth)
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 10,541,1982
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE
: 120 mg/kg
SEX/DURATION
: female 8-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - live birth index (measured after
birth)
Reproductive - Effects on Newborn - viability index (e.g., # alive at day
4
per # born alive)
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced
weight
gain)
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss,
Inc.,
41 E. 11th St., New York, NY 10003) V.11980Volume(issue)/page/year:
6,361,1986
** MUTATION DATA **
TYPE OF TEST
: Mutation test systems - not otherwise specified
TEST SYSTEM
: Rodent - rat Liver
DOSE/DURATION
: 100 umol/L
REFERENCE :
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House,
Fairview
Park, Elmsford, NY 10523) V.11987- Volume(issue)/page/year:
4,179,1990
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 1700 ug/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41
E.
11th St., New York, NY 10003) V.101987- Volume(issue)/page/year:
10(Suppl 10),1,1987
TYPE OF TEST
ROUTE OF EXPOSURE
TEST SYSTEM
DOSE/DURATION
REFERENCE :
:
:
:
:
Sperm Morphology
Oral
Bird - quail
200 ppm/42D (Continuous)
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
43,535,1978
*** REVIEWS ***
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 20,67,1979
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 20,67,1979
IARC Cancer Review:Group 2B
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.11979Volume(issue)/page/year:
7,56,1987
TOXICOLOGY REVIEW
STEVA8 Science of the Total Environment.
(Elsevier Science Pub. B.V.,
POB
211, 1000 AE Amsterdam, Netherlands)
Volume(issue)/page/year:
9,1,1978
V.1-
1972-
TOXICOLOGY REVIEW
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.11975/76Volume(issue)/page/year: 4,895,1978
TOXICOLOGY REVIEW
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For
publisher
information, see JTCTDW. Volume(issue)/page/year: 13,231,1978
TOXICOLOGY REVIEW
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest
South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
Volume(issue)/page/year: 2(3),671,1979
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRIA: Suspected Carcinogen, JAN1999
OEL-GERMANY;Carcinogen JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO KEPONE-air:10H CA TWA 0.001 mg/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M2969
No. of Facilities: 280 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 12600 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Inconclusive: Sperm morphology-human
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8899
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Kepone, 5508
NTP 8th Annual Report on Carcinogens, 1998:Reasonably Anticipated to be
Human Carcinogen
KEROSENE
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
LAST UPDATED
DATA ITEMS CITED
COMPOUND DESCRIPTOR
:
:
:
:
:
:
OA5500000
Kerosene
8008-20-6
199907
33
Agricultural Chemical
Tumorigen
Mutagen
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* Coal oil
* Deobase
* Kerosine
* Kerosine (petroleum)
* Nafta
* Straight-run kerosene
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST
: Standard Draize test
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 500 mg
REACTION SEVERITY
: Severe
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of
Toxicology,
Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)
V.11990- Volume(issue)/page/year: 1,30,1990
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 3570 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - cough
Gastrointestinal - nausea or vomiting
Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
TORAAK El Torax. (Montevideo, Uruguay) V.11952Volume(issue)/page/year: 15,263,1966
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka
Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.11959Volume(issue)/page/year: 22,883,1980
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 403 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - hallucinations, distorted perceptions
REFERENCE :
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For
publisher
information, see JTCTDW. Volume(issue)/page/year: 10,283,1977
TYPE OF TEST
ROUTE OF EXPOSURE
SPECIES OBSERVED
DOSE/DURATION
TOXIC EFFECTS :
:
:
:
:
LDLo - Lowest published lethal dose
Unreported
Human - man
1176 mg/kg
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena,
J.M.,
Springfield, IL, C.C. Thomas, 1970 Volume(issue)/page/year: 2,73,1970
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >5 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of
Toxicology,
Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)
V.11990- Volume(issue)/page/year: 1,30,1990
TYPE OF TEST
: LC - Lethal concentration
ROUTE OF EXPOSURE
: Inhalation
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: >5 gm/m3/4H
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of
Toxicology,
Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)
V.11990- Volume(issue)/page/year: 1,30,1990
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 10700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
1,156,1959
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intratracheal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 800 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
1,462,1959
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 4 gm/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - structural or functional change in
trachea
or bronchi
Lungs, Thorax, or Respiration - acute pulmonary edema
REFERENCE :
AJMSA9 American Journal of the Medical Sciences. (Slack Inc., 6900 Grove
Rd., Thorofare, NJ 08086) New series: V.11841Volume(issue)/page/year:
221,531,1951
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - structural or functional change in
trachea
or bronchi
Lungs, Thorax, or Respiration - acute pulmonary edema
REFERENCE :
AJMSA9 American Journal of the Medical Sciences. (Slack Inc., 6900 Grove
Rd., Thorofare, NJ 08086) New series: V.11841Volume(issue)/page/year:
221,531,1951
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intratracheal
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 800 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - structural or functional change in
trachea
or bronchi
Lungs, Thorax, or Respiration - acute pulmonary edema
REFERENCE :
AJMSA9 American Journal of the Medical Sciences. (Slack Inc., 6900 Grove
Rd., Thorofare, NJ 08086) New series: V.11841Volume(issue)/page/year:
221,531,1951
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 2835 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - respiratory stimulation
Endocrine - hypoglycemia
REFERENCE :
AIMEAS Annals of Internal Medicine. (American College of Physicians,
4200
Pine St., Philadelphia, PA 19104) V.11927-
Volume(issue)/page/year:
21,803,1944
TYPE OF TEST
: LD - Lethal dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: >2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of
Toxicology,
Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)
V.11990- Volume(issue)/page/year: 1,30,1990
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 6600 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - structural or functional change in
trachea
or bronchi
Lungs, Thorax, or Respiration - emphysema
Lungs, Thorax, or Respiration - chronic pulmonary edema
REFERENCE :
AIMEAS Annals of Internal Medicine. (American College of Physicians,
4200
Pine St., Philadelphia, PA 19104) V.11927Volume(issue)/page/year:
21,803,1944
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 180 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory stimulation
Behavioral - tremor
Behavioral - coma
REFERENCE :
AIMEAS Annals of Internal Medicine. (American College of Physicians,
4200
Pine St., Philadelphia, PA 19104) V.11927Volume(issue)/page/year:
21,803,1944
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intratracheal
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
3,689,1961
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 20 gm/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - respiratory stimulation
Endocrine - hypoglycemia
REFERENCE :
AIMEAS Annals of Internal Medicine. (American College of Physicians,
4200
Pine St., Philadelphia, PA 19104) V.11927Volume(issue)/page/year:
21,803,1944
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 540 gm/kg/90D-I
TOXIC EFFECTS :
Liver - changes in liver weight
Endocrine - changes in adrenal weight
Endocrine - antidiuresis
REFERENCE :
BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001,
00-068
Warsaw 1, Poland) V.41971- Volume(issue)/page/year: 21,187,1988
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 84 gm/kg/35D-I
TOXIC EFFECTS :
Liver - changes in liver weight
Endocrine - changes in spleen weight
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.11967- Volume(issue)/page/year: 35,516,1984
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Administration onto the skin
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 4500 mg/kg/3W-I
TOXIC EFFECTS :
Blood - pigmented or nucleated red blood cells
Skin and Appendages - dermatitis, other (after systemic exposure)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0533973
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 25 uL/plate
REFERENCE :
CBTOE2 Cell Biology and Toxicology. (Princeton Scientific Pub., Inc.,
301
N. Harrison St., CN 5279, Princeton, NJ 08540) V.11984Volume(issue)/page/year: 2,63,1986
*** REVIEWS ***
IARC Cancer Review:Animal Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of
Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210)
V.11972- Volume(issue)/page/year: 45,39,1989
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.11936- Volume(issue)/page/year:
54,7740,1989
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-POLAND: MAC(TWA) 100 mg/m3, MAC(STEL) 300 mg/m3, JAN1999
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO KEROSENE-air:10H TWA 100 mg/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept.
of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - T1768
No. of Facilities: 69564 (estimated)
No. of Industries: 321
No. of Occupations: 186
No. of Employees: 1075728 (estimated)
No. of Female Employees: 96255 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X6889
No. of Facilities: 22 (estimated)
No. of Industries: 1
No. of Occupations: 3
No. of Employees: 790 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8968
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1999
NIOSH Analytical Method, 1994: Naphthas, 1550
KETAMINE HYDROCHLORIDE
RTECS NUMBER
: GW1400000
CHEMICAL NAME
: Cyclohexanone,
2-(2-chlorophenyl)-2-(methylamino)-,
hydrochloride, (+-)CAS REGISTRY NUMBER
: 1867-66-9
OTHER CAS REGISTRY NOS. : 81771-21-3
96448-41-8
42551-62-2
LAST UPDATED
: 199703
DATA ITEMS CITED
: 21
MOLECULAR FORMULA
: C13-H16-Cl-N-O.Cl-H
MOLECULAR WEIGHT
: 274.21
WISWESSER LINE NOTATION : L6VTJ BM1 BR BG &GH
COMPOUND DESCRIPTOR
: Drug
Mutagen
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Calipsol
* (+-)-2-(o-Chlorophenyl)-2-(methylamino)cyclohexanone hydrochloride
* CI 581
* CL 369
* CN-52,372-2
* Kalipsol
* Ketaject
* Ketalar
* Ketamine hydrochloride
* (+-)-Ketamine hydrochloride
* Ketanest
* Ketaset
* Ketavet
* Ketavet 100
* Ketolar
* Vetalar
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Unreported
SPECIES OBSERVED
: Human - man
DOSE/DURATION
: 1 mg/kg
TOXIC EFFECTS :
Behavioral - hallucinations, distorted perceptions
Behavioral - coma
Behavioral - analgesia
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical
Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD
21010)
Volume(issue)/page/year: NX#03551
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Human
DOSE/DURATION
: 2 mg/kg
TOXIC EFFECTS :
Behavioral - analgesia
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.11857Volume(issue)/page/year:
2,943,1976
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Human - child
DOSE/DURATION
: 4 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
REFERENCE :
AEMED3 Annals of Emergency Medicine. (American College of Emergency
Physicians, 1125 Executive Circle, Irving, TX 75038)
Volume(issue)/page/year: 22,613,1993
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Human - child
DOSE/DURATION
: 4 mg/kg
TOXIC EFFECTS :
Cardiac - pulse rate increase, without fall in BP
Lungs, Thorax, or Respiration - other changes
REFERENCE :
AJEMEN American Journal of Emergency Medicine. (WB Saunders,
Philadelphia,
PA) V.11983- Volume(issue)/page/year: 14,580,1996
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Multiple routes
SPECIES OBSERVED
: Human - infant
DOSE/DURATION
: 11587 ug/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
BJANAD British Journal of Anesthesia. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.11923Volume(issue)/page/year:
58,573,1986
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 447 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,264,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 224 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
18,185,1971
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 58880 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,264,1982
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intraspinal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 5 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without
sensory
change
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark)
V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
56,50,1985
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 617 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,264,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 224 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,264,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 55900 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,264,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 356 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZYYZEW Zhongguo Yaolixue Yu Dulixue Zazhi. (Chinese Pharmacological
Society, 27 Tai-Ping Road, Beijing 100850, China) V.11986Volume(issue)/page/year: 9,96,1995
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intramuscular
SPECIES OBSERVED
: Rodent - guinea pig
DOSE/DURATION
: 361 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
VHTODE Veterinary and Human Toxicology. (American College of Veterinary
and
Comparative Toxicology, Publication Office, Comparative Toxicology,
Manhattan, KS 66506) V.191977- Volume(issue)/page/year:
24,410,1982
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Bird - chicken
DOSE/DURATION
: 67900 ug/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
Behavioral - sleep
Behavioral - tremor
REFERENCE :
AJVRAH American Journal of Veterinary Research. (American Veterinary
Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196)
Volume(issue)/page/year: 45,531,1984
V.1-
1940-
** REPRODUCTIVE DATA **
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 1700 mg/kg
SEX/DURATION
: female 1-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
REANBJ Revista Espanola de Anestesiologia y Reanimacion. (Barcellona,
Spain) V.1-12, 1954-65. Volume(issue)/page/year: 26,137,1979
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 375 mg/kg
SEX/DURATION
: female 1-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - cardiovascular
(circulatory) system
Reproductive - Specific Developmental Abnormalities - hepatobiliary
system
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
RCOCB8 Research Communications in Chemical Pathology and Pharmacology.
(PJD
Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.11970Volume(issue)/page/year: 54,413,1986
TYPE OF TEST
: TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE
: 120 mg/kg
SEX/DURATION
: female 11-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation,
see
PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.21939- Volume(issue)/page/year: 54(5),58,1991
** MUTATION DATA **
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 5 umol/L
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3,
D-1000
Berlin 33, Fed. Rep. Ger.) V.321974- Volume(issue)/page/year:
59,124,1986
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X6145
No. of Facilities: 651 (estimated)
No. of Industries: 2
No. of Occupations: 6
No. of Employees: 6373 (estimated)
No. of Female Employees: 3907 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
KOJIC ACID
RTECS NUMBER
CHEMICAL NAME
CAS REGISTRY NUMBER
BEILSTEIN REFERENCE NO.
REFERENCE
LAST UPDATED
DATA ITEMS CITED
MOLECULAR FORMULA
MOLECULAR WEIGHT
WISWESSER LINE NOTATION
COMPOUND DESCRIPTOR
:
:
:
:
:
:
:
:
:
:
:
UQ0875000
4H-Pyran-4-one, 5-hydroxy-2-(hydroxymethyl)501-30-4
0120895
5-18-02-00516 (Beilstein Handbook Reference)
199612
12
C6-H6-O4
142.12
T6O DVJ B1Q EQ
Drug
Mutagen
SYNONYMS/TRADE NAMES :
* 5-Hydroxy-2-(hydroxymethyl)-4-pyrone
* Kojic acid
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et
al.,
eds., Washington, DC, American Soc. for Microbiology, 1978
Volume(issue)/page/year: 3,1755,1978
TYPE OF TEST
ROUTE OF EXPOSURE
: LDLo - Lowest published lethal dose
: Oral
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 4 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ
08736)
V.11869- Volume(issue)/page/year: 155,302,1945
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca
Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 5,393,1981
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Subcutaneous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1500 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ
08736)
V.11869- Volume(issue)/page/year: 155,302,1945
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 1500 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ
08736)
V.11869- Volume(issue)/page/year: 155,302,1945
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Mammal - dog
DOSE/DURATION
: 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et
al.,
eds., Washington, DC, American Soc. for Microbiology, 1978
Volume(issue)/page/year: 3,1755,1978
TYPE OF TEST
: LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rabbit
DOSE/DURATION
: 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et
al.,
eds., Washington, DC, American Soc. for Microbiology, 1978
Volume(issue)/page/year: 3,1755,1978
** MUTATION DATA **
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 2 mg/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
67,367,1979
TYPE OF TEST
: Mutation in microorganisms
TEST SYSTEM
: Bacteria - Salmonella typhimurium
DOSE/DURATION
: 500 ng/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11964- Volume(issue)/page/year:
58,193,1978
TYPE OF TEST
: Cytogenetic analysis
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 4500 mg/L
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
59,213,1991
TYPE OF TEST
: Sister chromatid exchange
TEST SYSTEM
: Rodent - hamster Ovary
DOSE/DURATION
: 4500 mg/L
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.11977- Volume(issue)/page/year:
59,213,1991
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
KRYPTOFIX
RTECS NUMBER
: MP4750000
CHEMICAL NAME
:
4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo-(8,8,8)-hex
acosane
CAS REGISTRY NUMBER
: 23978-09-8
BEILSTEIN REFERENCE NO. : 0620282
LAST UPDATED
: 199812
DATA ITEMS CITED
: 4
MOLECULAR FORMULA
: C18-H36-N2-O6
MOLECULAR WEIGHT
: 376.56
WISWESSER LINE NOTATION : T-18--18- A B C D E F G H CO FO IN LO OO RN UO
A&OTJ
SYNONYMS/TRADE NAMES :
* Crypt-2,2,2
* 2,2,2-Crypt
* Cryptand 222
* Cryptand 2.2.2
* Cryptand C 222
* 2,2,2-Cryptand
* Cryptate 222
* 2,2,2-Cryptate
* Cryptating agent 222
* Cryptofix 222
* 13,16,21,24-Hexaoxa-1,10-diazabicyclo-(8,8,8)-hexacosane
* Kryptand 222
* Kryptofix 222
* Ligand 222
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intraperitoneal
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 110 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
41,113,1977
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - rat
DOSE/DURATION
: 35 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
41,113,1977
TYPE OF TEST
ROUTE OF EXPOSURE
: LD50 - Lethal dose, 50 percent kill
: Intraperitoneal
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 153 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
41,113,1977
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
: Intravenous
SPECIES OBSERVED
: Rodent - mouse
DOSE/DURATION
: 32 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.11959- Volume(issue)/page/year:
41,113,1977