Supplement 1 – Radiation doses for organs at risk (OARs) located inside the boost volume
SEB
SIB
Dmax(Gy)
Dmean(Gy)
Dmax(Gy)
Dmean(Gy)
Right optic nerve*
54.08
47.06
54.1
48.81
Brainstem
54.36
38.89
52.16
38.52
Brainstem
55.21
32.99
51.77
32.66
Brainstem**
59.9
55.78
62.22
55.23
Brainstem
54.99
29.5
53.9
28.59
Brainstem**
60.52
56.85
62.20
55.45
Brainstem
55.69
44.52
54.81
41.33
Brainstem
55.95
38.76
55.46
33.72
Chiasm
52.9
48.47
51.38
46.93
Chiasm
53.95
49.7
52.32
44.93
This table relates to those 8 patients in whom 10 OARs (listed above) were located within the boost
volume. In one case (*) both Dmean and Dmax were higher in SIB method. In 2 other cases (**)
we observed a higher Dmax for the brainstem with SIB method. In the other cases Dmean and
Dmax in the SIB method were lower when compared with the SEB method.
Supplement 2 – Number of patients in whom the total delivered dose to the organs at
risk (OARs) exceeded the tolerance dose, separately mentioned for maximum dose
(Dmax) and mean dose (Dmean) in each method.
SEB
SIB
Dmax
Dmean
Dmax
Dmean
Right optic nerve
1
0
1
0
Left optic nerve
0
0
0
0
Chiasm
1
0
1
0
Brainstem
2
1
2
0
Right retina
0
0
1
0
Left retina
2
0
2
0
Right lachrymal gland
3
0
3
0
Left lachrymal gland
4
1
3
1
Right lens
14
9
11
4
Left lens
14
12
11
6
Right eyeball
0
0
0
0
Left eyeball
2
0
2
0
Supplement 3 – Mean of Biological Effective Doses (BED) to the OARs
Right optic nerve
Left optic nerve
Chiasm
Brainstem
Right retina
Left retina
Right lachrymal gland
Left lachrymal gland
Right lens
Left lens
Right eyeball
Left eyeball
Mean of BED (Gy)
SEB
SIB
38.13
35.48
39.14
35.89
64.27
61.03
58.30
55.86
20.22
18.36
21.81
18.48
19.18
17.19
20.03
18.53
5.93
5.27
6.67
5.98
13.58
11.96
14.95
12.82