Monday, December 15 2.00 pm: Welcome Opening Session Chair: Raina Seupel T01 Dr. Stefan Weigand (2:15 pm) Next generation Protein therapeutics: multi-specific antibodies, fusion proteins, Small-Large Molecule combinations Chair: Benjamin Merget T02 Dr. Johannes Schiebel (3.00 pm) Substrate and Inhibitor Recognition by Staphylococcus aureus FabI / Fragment-based Methods for the Development of Anti-infectives 3.45 pm – 4.15 pm: Coffee break Pathogen Virulence and Fitness Chair: Sandra Eltschkner T03 Benjamin Merget (4.15 pm) An Accurate and Quantitative Prediction Model of Drug-Target Residence Time for Staphylococcus aureus FabI Inhibitors based on Steered Molecular Dynamics T04 Christina Popp (4.35 pm) Fitness Costs of Drug Resistance in Candida albicans T05 Melanie Mühlenkamp (4.55 pm) YadA-Dependent Interaction of Yersinia enterocolitica with Vitronectin T06 Anastasija Reimer (5.15 pm) Analysis of the Interaction between Neisserial Porin and Endothelial Receptor 5.35 - 5.50 pm: break 5.50 pm: poster appetizers (P05 - P09, P14 - 22) 6.15 pm: dinner 7.00 pm- open end: poster session Tuesday, December 16 Pathogen Biology and Cell Wall Chair: Lina Thoma T07 Nils Ladwig (9.00 am) The SER/THR Kinase PAKI is involved in Differentiation and Sporulation of Streptomyces coelicolor T08 Alexander Schneider (9.20 am) Advanced Peptidoglycan Analytics -- New Insights in Bacterial Cell Wall Turnover and Composition T09 Dr. Marina Borisova (9.40 am) Cell Wall Recycling in Recycling Staphylococcus aureus -- Role of the NAcetylmuramic Acid 6 Phosphate Etherase T10 Prof. Dr. Christoph Mayer (10.00 am) Peptidoglycan Recycling -- A Major Salvage Pathway of Bacteria and Novel Drug Target 10.20 – 10.50 am: Coffee Break Medicinal Chemistry and Inhibitor Design Chair: Ines Schmidt T11 Raina Seupel (10.50 am) Investigations of the Mode of Action of N,C-coupled Naphthylisoquinoline Alkaloids in Leishmania major and Derivatization for the Means of Photoaffinity Labeling T12 Franziska von Hammerstein (11.10 am) Synthesis, Characterization and Screening of Dengue Virus NS2B-NS3 Protease Inhibitors T13 Florian Seufert (11.30 am) Development of MIP-Inhibitors 11.50 am: Poster appetizers (P23 - P26, P30 - P36, P39 - P40) 1.00 pm: Lunch/Poster session 3.00 pm: social program / Geocaching Evening Lecture Chair: Thomas Bartossek T14 Prof. Dr. August Stich (6.00 pm) The challenge of Ebola: Lessons learnt! 7.30 pm: Wine tasting Wednesday, December 17 Analytics and Pharmacokinetics Chair: Michael Berninger T15 Dieudonné Tshitenge (9.00 am) New Potential Markers for Kilma, a Congolese Phytomedicine T16 Nina Hecht (9.20 am) In silico Optimization of in vivo Efficacy Study Designs for New Chemical Entities 9.45 – 10.15 am: Coffee Break 10.15 am: Workshops 12.30 pm: Closing remarks 1.00 pm: Lunch