Chemistry 4000 B
Fall 2010
Nuclear Magnetic Resonance Spectroscopy
Instructor:
Office:
Phone:
E-mail:
Dr. Paul Hazendonk
E852
329-2657
paul.hazendonk@uleth.ca
Course objectives and structure.
The objective of this course is to provide a deeper theoretical insight into the
NMR experiments available today. This is a “capstone course”, meaning that it requires
the student to incorporate ideas from courses in other sub-disciplines in chemistry. In
this case one will rely on material covered in organic spectroscopy, thermodynamics,
quantum mechanics, and stereo-chemistry courses. It is also assumed that the student is
familiar with the use of NMR along with other spectroscopic techniques to determine the
structure of organic and/or inorganic systems. This course will start with a rudimentary
survey of the theory of NMR, which will provide the background to explain the basic
time-dependent NMR techniques. These in turn will then serve as the basis for
explaining the more complex experiments used extensively today by academic and
commercial investigators into the study of structure and dynamics of complex organic
and biochemical systems in both the solution and solid state.
As this is an advanced class the student will be expected to prepare for lecture by
reading the assigned material for each class. The lectures/seminars will only cover some
of the more salient points of the assigned reading and the material will be discussed in
class in an informal manner, where the student is expected to actively participate.
Course Materials:
 Spin Dynamics, M. Levitt, Wiley, 2001.
 Additional reading material for graduate students will be provided.
Recommended Background Reading:
Undergraduate students:
 Timothy D.W. Claridge, “High-resolution NMR Techniques in Organic
Chemistry”, Pergamon, 1999. (This book is kept on reserve in the library)
 R.M. Silverstein, F.X. Webster, D.J. Kiemle, `Spectroscopic Identification of
Organic Compounds`, 7-ed., Wiley, 2005.
Graduate students:
 C.P. Slichter, “Principles of Magnetic Resonance”, 3-rd ed., Springer 1990
 M. Duer,``Solid state NMR Spectroscopy; Principles and Applications``,
Blackwell Science, 2002.
Background Mathematics
 F.W. Byron & R.W. Fuller “Mathematics of Classical and Quantum Physics”,
Dover 1992.
Grading Scheme:
Lab :
Paper:
Presentation:
Attendance:
Class participation:
Additional Assignments





Undergrads
40 %
15 %
15 %
10 %
20 %
X
Grads
30 %
20 %
20 %
X
X
30 %
Each student is to choose a topic, which has to be approved by the instructor, on
which a paper of at least 2000 words is to be prepared and presented to the class
as a 25-minute seminar. A list of possible topics will be presented later in the
term. Seminars will take place at some additionally scheduled time and will be
announced at a later date.
Attendance is mandatory!! Any unexcused absences will lead to forfeiture of
entire mark value.
Students are expected to be prepared for class to engage in the discussion.
Regular reading will be assigned along with sample problems. The class
participation mark will be used as an assessment of student engagement and
preparedness.
Graduate students will attend an additional lecture time to cover the extra course
material.
Participation in the NMR journal club is Strongly encouraged.
Office Hours:
I have an open door policy. Feel free to drop by at anytime. If I am in my office I will
make myself available.
Laboratories and Tutorials:
There is a lab component to the course on Wednesday afternoons run by T. Montina..
During the tutorial sample problems will be solved using various software tools. Also
some time will be set aside to work on the assignments.
Topics (undergraduate)
I
II
III
Nuclear Magnetism
Matter
Magnetism
NMR spectroscopy
The NMR Experiment
The NMR spectrometer
Fourier Transform NMR
Nuclear Spin Interactions
Review of quantum mechanics
Nuclear spin Hamiltonian
Spin systems in isotropic liquids
IV
V
VI
Uncoupled Spin-1/2
Single Spin-1/2
Ensemble of Spin-1/2
Experiments with Non-interacting spins
Coupled Spin-1/2
Homonuclear AX system.
Experiments in AX systems.
Multiple spin-1/2 systems
Motion and Relaxation
Motion
Relaxation
Graduate students:
S.C. Smith, W.E. Palke, J.T. Gerig,`` Hamiltonians of NMR IV``, Concepts in Magnetic
Resonance, 4, 107 (1992)
S.C. Smith, W.E. Palke, J.T. Gerig,`` Hamiltonians of NMR II``, Concepts in Magnetic
Resonance, 4, 181 (1992)
S.C. Smith, W.E. Palke, J.T. Gerig,`` Hamiltonians of NMR III``, Concepts in Magnetic
Resonance, 5, 151 (1993)
S.C. Smith, W.E. Palke, J.T. Gerig,`` Hamiltonians of NMR IV``, Concepts in Magnetic
Resonance, 6, 137 (1994)