CURRICULUM VITAE
FRANCISCO TALAVERA
11809 Jefferson Plz
Phone: 402/896-1190
Omaha, NE 68137
Fax: 402/891-2368
e-mail: ftalaver@cox.net
BORN: Lorain, Ohio, U.S.A.
CITIZENSHIP: U.S.A.
WORK EXPERIENCE
June, 1999 – Present, WebMD, 11809 Jefferon Plz (Home Office)
- Editor-in-Chief, Medscape Drug Reference
February 2011-Present, Adjunct Assistant Professor, University of Nebraska
Medical Center College of Pharmacy
Omaha, NE
Omaha, NE
March, 2009-August 2010, NoFrills Pharmacy, 11163 Mill Valley Road,
-Relief Pharmacist
Omaha, NE
September 2006 – August 2008 Medicap Pharamacy, 2814 S. 108th St,
-Owner
Omaha, NE
January, 2001 – 2003
Pharmerica, 6542 S. 118th St,
-Relief Pharmacist (Long term care)
Omaha, NE
December, 2000 – 2001
-Relief pharmacist
Niles, IL
RPh On The Go USA, Inc, 5940 W. Tuhey Av,
February, 2000 – December, 2000 Omnicare of Nebraska, 10004 S. 152nd St.
-Part-time Pharmacist (Long term care)
Omaha, NE
January, 1995 – May 1999
-Pharmacy Intern (Retail)
Omaha, NE
Kohll’s Pharmacy, 2923 Leavenworth ST.
EDUCATION:
Pharm D., May, 1999
Creighton University (Omaha, NE)
Business Certificate, May, 1999
Francisco Talavera, Pharm.D., Ph.D.
Creighton University (Omaha, NE)
32 credit hours in business administration
Postdoctoral Fellow, 1988-1994
University of Michigan Hospitals (Ann Arbor, MI)
Sponsor: Dr. K.M.J. Menon
Endocrinology and Cancer research
Research areas:
1.
Studies on growth factors and oncogenes in normal and neoplastic human
endometrium.
2.
Effects of intracellular cholesterol concentrations on the regulation of the HDL
receptor in the ovary.
3.
Role of IGF-I in ovarian cell function.
Ph.D., December, 1987
Washington State University (Pullman, WA)
- Major: Reproductive Physiology
- Major Advisor: Dr. Boon P. Chew
- Dissertation title: "Effects of retinol, retinoic acid and -carotene on ovarian cell function in
vitro". Studies on the effects of retinol, retinoic acid and -carotene on progesterone secretion by
bovine and porcine ovarian luteal cells in vitro.
M.S., November, 1983
North Dakota State University (Fargo, ND)
- Major: Reproductive Physiology
- Major Advisor: Dr. Gary L. Williams
- Thesis title: "Effects of increased dietary lipid on ovarian steroid secretion in Holstein heifers".
Involved determinations of circulating levels of estradiol 17, progesterone and cholesterol in
pubertal Holstein heifers fed with high lipid diets.
TECHNICAL EXPERTISE
1.
Flow cytometry (cell cycle studies)
2.
Solution hybridization
3.
Tyrosine phosphorylation studies (including cell-free systems)
4.
Transfections
5.
Iodination of peptide hormones and lipoproteins
6.
Cell cultures
7.
PCR
8.
Receptor crosslinking and binding assays
9.
Radioimmunoassays
10.
Nuclear run-on transcription assays
11.
Protein Kinase C assay
12.
In situ hybridization
13.
Northern blots
14.
Western blots
15.
Ligand blots
Francisco Talavera, Pharm.D., Ph.D.
TEACHING EXPERIENCE
1.
Basic Principles in Physiology
- Assisted in lectures
2.
Basic Principles in Physiology (laboratory)
- Taught measurements of functional processes in physiology.
HONORS/AWARDS
1.
National research service award from the National Cancer Institute. 1989-1992.
2.
Hoffman-La Roche Scholarship. 1995-1999
3.
Dean’s Honor Roll. 1998-1999
4.
All-American Scholar Collegiate Award. 1999
INTERESTS AND ACTIVITIES
1.
June 22, 1997 – Offered a diabetes workshop for the Spanish-speaking
community of Omaha, NE
2.
Phi Delta Chi, Pharmacy Fraternity - President, 1997-1998
6.
Excellence in University Teaching. WSU-GPSA, 1987.
PROFESSIONAL CLERKSHIPS
June 1998
Community Practice at Osco Drug
July 1998
Internal Medicine at St. Joseph Hospital
August 1998
Long Term Care at Internal Medicine Clinic
September 1998 Nutrition at St. Joseph Hospital
October 1998
Oncology at Midlands Hospital
PRECEPTOR
Michael Daeges, Pharm.D.
Michael Monaghan, Pharm.D.
Ann Ryan-Haddad, Pharm.D.
Donald Fagan, Pharm.D.
Gary Guritz, Pharm.D.
November 1998
January 1999
February 1999
March 1999
April 1999
Pammela Foral, Pharm.D.
F. Michael Kleine, R.Ph.
Patrick Malone, Pharm.D.
Michael Monaghan, Pharm.D.
Julie Stading, Pharm.D.
Clinical Kinetics at Clarkson Horpital
Hospital Practice at St. Joseph Hospital
Drug Information Center at Creighton U.
Academic Clerkship
Ambulatory Pharmacy at VA Hospital
PUBLICATIONS:
A.
1.
2.
Books
Pharmacy Review: Pearls of Wisdom (Boston Medical Publishing Corp, 2001)
Rapid Fire: Pharmacy Review (Jones and Bartlett Publishers, 2006)
B.
Refereed Journals:
1.
Burke, J.J., Talavera, F., Menon K.M.J. 1997. Regulation of PTP1D mRNA by peptide growth
factors in the human endometrial cell line HEC-I-A. J. Soc. Gyn. Investigation. 4:310-315
2.
Connor, P., Talavera, F., Kang, J.S. Burke J. Roberts J. Menon KMJ. 1997. Epidermal growth
factor activates protein kinase C in the human endometrial cell line HEC-I-A. Gynecologic
Francisco Talavera, Pharm.D., Ph.D.
Oncology 67:46-50
3.
Bergman, C.A., Talavera, F., Christman, G.M., Baker, V.V., Roberts, J.A. Menon, K.M.J.
Transforming growth factor-beta negatively modulates proliferation and c-fos expression of the
human endometrial adenocarcinoma cell line HEC-I-A. Gynecologic Oncology 65:63-68
4.
Talavera, F., Chen Z, Menon, K.M.J. 1996. IGF-I and cyclic AMP signaling in the luteinized rat
ovary: Cyclic AMP may increase the stability of tyrosine phosphorylated insulin receptor
substrate-I. Biochim. Biophys Acta 1310:10-18
5.
Talavera, F., Bergman C., Pearl M.L., Connors P., Roberts, J.A., Menon, K.M.J. 1995. cAMP
and PMA potentiate the effects of IGF-I in the proliferation of endometrial adenocarcinoma cell
lilne HEC-I-A by acting at the G1 phase of the cell cycle. Cell Proliferaion. Cell Proliferation
28:121-136
6.
Gretz H.F., III, Talavera, F., Pearl, M.L., Lelle, R.J., Roberts, J.A., Menon, K.M.J.1994. Protein
kinase C dependent and independent pathways mediate epidermal growth factor (EGF) effects in
human endometrial adenocarcinoma cell line HEC-I-A. Gynecologic Oncology 58:228-233
7.
Pearl, M.L., Talavera, F., Gretz, H.F., III, Roberts, J.A., Menon, K.M.J. 1993. Mitogenic activity
of growth factors in the human endometrial carcinoma cell lines HEC-I-A and KLE.
Gynecologic Oncology 49: 325-332
8.
Lelle, R.J., Talavera, F., Reynolds, R.K., Roberts, J.A., Menon, K.M.J. 1993. Epidermal growth
factor receptor expression in three different human endometrial cancer cell lines. Cancer 72: 519525
9.
Ferreri K., Talavera F., Menon, K.M.J. 1992. Regulation of high density lipoprotein receptors by
intracellular cholesterol in rat luteal cell cultures. Endocrinology 131:2059-2064
10.
Talavera, F. and Menon, K.M.J. 1991. Studies on rat luteal cell response to insulin-like growth
factor I (IGF-1): identification of a specific cell membrane receptor for IGF-I in the luteinized rat
ovary. Endocrinology 129:1340-1346
11.
Talavera, F., Reynolds, R.K., Roberts, J.A., Menon, K.M.J. 1990. Insulin-like growth
factor I receptor in normal and neoplastic endometrium. Cancer Research 50:3019-3024
12.
Reynolds, R.K., Talavera, F., Roberts, J.A., Hopkins, M.P., Menon, K.M.J. 1990.
Characterization of epidermal growth factor receptor in normal and neoplastic human
endometrium. Cancer 66:1967-1974
13.
Reynolds, R.K., Talavera, F., Roberts, J.A., Menon, K.M.J. 1990. Regulation of Epidermal
Growth Factor and Insulin-like Growth Factor-I receptors by estradiol and progesterone in
normal and neoplastic endometrial cell cultures. Gynecologic Oncology 38:396-406
14.
Talavera, F. and Menon, K.M.J. 1989. Regulation of luteal cell HDL receptor: Upregulation in
Francisco Talavera, Pharm.D., Ph.D.
response to changes in intracellular cholesterol concentrations. Endocrinology 125:2015-2021
15.
Talavera, F. and Chew, B.P. 1988. Comparative role of retinol, retinoic acid and -carotene on
progesterone secretion by porcine corpora lutea in vitro. J. Reprod. Fert. 82:611-615
16.
Talavera, F., Park, C.S. and Williams, G.L. 1985. Relationships among dietary lipid intake,
serum cholesterol and ovarian function in holstein heifers. J. Anim. Sci. 60:1045-1051
17.
Williams, G.L., Talavera, F. Petersen, B.J. and Tilton, J.E. 1983. Coincident secretion of folliclestimulating hormone in beef cows postpartum: Effects of suckling and low-level increases of
systemic progesterone. Biol. Reprod. 29:362-373
C.
Abstracts/presentations at national conferences:
1.
Talavera F., Bergman C., Burke J., Roberts J.A., Menon, K.M.J. 1995. Cyclic AMP and PMA
amplify the effects of IGF-I in the mitogenic activity of endometrial adenocarcinoma cell line
HEC-I-A by acting at the G1 phase of the cell cycle. Soc. Gyn. Invest. 42:293
2.
Talavera F., Connor P., Bergman C., Roberts J.A., Menon K.M.J. 1994. Cyclic adnosine 3'5'
monophosphate enhances insulin-like growth factor-I mediated phosphorylation of a 170 KDa
substrate in endometrial adenocarcinoma cell line HEC-I-A. Soc. Gyn. Invest. 41:252
3.
Bergman C., Talavera F., Roberts J.A., Menon K.M.J., 1994. Transforming growth factor-
negatively modulates growth of the human endometrial adenocarcinoma cell line HEC-I-A. Soc.
Gyn. Invest. 41:253
4.
Kang, J.S., Talavera, F., Connor, P., Bergman, C., Roberts, J.A. and Menon, K.M.J. 1994.
Epidermal growth factor stimulates c-Fos mRNA expression and mitogennesis in human
endometrial, adenocarcinoma cell line, HEC-I-A Soc. Gyn. Invest.
5.
Talavera, F., Chen Z., Menon K.M.J. 1993. Human chorionic gonadotropin enhances insulin like
growth factor-I mediated phosphorylation of a 183 KDa substrate in rat luteinized ovarian cells.
Endocrinology 75: 1143
6.
Talavera, F., Pearl, M.L., Roberts, J.A., Menon, K.M.J. 1993. Insulin-like growth factor-I and
epidermal growth factor increases c-myc RNA in endometrial cell line HEC-1-A without
inducing additional protein synthesis. Soc. Gyn. Invest. 40:231
7.
Connor, P., Talavera, F, Kang, J., Roberts, J.A., Menon, K.M.J. 1993. Epidermal growth factor
stimulates protein kinase C pathway in endometrial adenocarcinoma cell line, HEC-1-A. Soc.
Gyn. Invest. 40:232
8.
Talavera, F., Pearl, M.L., Roberts, J.A., Menon, K.M.J. 1992. Adenosine 3',5' monophosphate
potentiates the mitogenic effects of Insulin-like growth factor-I in the endometrial carcinoma cell
line HEC-I-A. Endocrinology 74:1281A
Francisco Talavera, Pharm.D., Ph.D.
9.
Talavera, F., Pearl, M.L., Roberts, J.A., Menon, K.M.J. 1992. Effect of the protein kinase C
agonist Phorbol 12-Myristate 13 Acetate (PMA) and adenylate cyclase agonist forskolin in the
mitogenic activity of endometrial carcinoma cell line HEC-1-A. Soc. Gyn. Invest. 39:462A
10.
Pearl, M.L., Talavera, F., Roberts, J.A, Menon, K.M.J. 1992. Mitogenic activity of growth
factors on endometrial carcinoma cell lines. Soc. Gyn. Invest. 39:204A
11.
Talavera, F., Gretz, H.G., Roberts, J.A., Menon, K.M.J. 1991. Differences in IGF-I binding
between moderately differentiated and undifferentiated endometrial adenocarcinoma cell lines.
Endocrinology 73:1075A
12.
Ferreri, K., Talavera, F., Menon, K.M.J. 1991. Biphasic regulation of the HDL receptor in the rat
luteinized ovary. Endocrinology, 73:135A2
13.
Talavera, F. and Menon, K.M.J. 1991. Expression of the IGF-I receptor gene in the corpus
luteum and receptor mediaded amplification by IGF-I of hCG and 8-bromo-cAMP induced
progestin in rat luteal cells. Second International Symposium on IGFs/Somatomedins. 2:61A
14.
Gretz, H.F., Talavera, F., Lelle, R., Roberts, J.A., Menon, K.M.J. 1991. Epidermal growth factor
(EGF) increases 3H thymidine incorporation and c-myc mRNA in a human endometrial
adenocarcinoma cell line. Western Association of Gynecologic Oncologists; Annual Meeting
15.
Lelle, R.J., Talavera, F,. Reynolds, R.K., Roberts, J.A., Menon, K.M.J. 1990. Characterization of
the epidermal growth factor receptor in a human endometrial cancer cell line (KLE). Deutsche
Geseuschaft Fur Gynakoligie und Geburtshilfe
16.
Talavera, F. and Menon, K.M.J. 1990. Receptor mediated amplification by IGF-I of hCGinduced and HDL supported progestin production in rat luteal cells. Endocrinology 72:610A
17.
Talavera, F., Reynolds R.K., Roberts, J.A., Menon, K.M.J. 1990. Insulin like growth factor-I and
epidermal growth factor receptor in normal and neoplastic endometrium. Soc. Gyn. Invest.
37:23A
18.
Lelle, R.J., Talavera, F., Gretz, H., Roberts, J.A., Menon, K.M.J. 1990. Epidermal growth factor
(EGF) receptors and c-myc oncogene expression in human endometrial cells lines. Soc. Gyn.
Invest. 38:500A
19.
Reynolds, R.K., Talavera, F., Roberts, J.A., Hopkins, M.A., Menon, K.M.J. 1990. Regulation of
epidermal growth factor (EGF) and insulin-like growth factor I (IGF-I) receptors by estradiol and
progesterone in normal and neoplastic endometrial cell cultures. Soc. Gyn. Onc.; Annual Mtg.
20.
Talavera, F., Reynolds, R.K., Roberts, J.A, Hopkins, M.P., Menon, K.M.J. 1989.
Characterization of the IGF-I receptor in the normal and neoplastic human endometrium.
Western Association of Gynecologic Oncologists; Annual Meeting
Francisco Talavera, Pharm.D., Ph.D.
21.
Talavera, F. and Menon K.M.J. 1989. Cholesterol transport in the rat corpus luteum: Evidence
for bidirectional regulation of cholesterol transport between HDL particles and luteal cells.
Endocrinology 123:255A
22.
Menon, K.M.J., Talavera, F., Roberts, J.R. 1989. Evidence that rat luteal cells HDL receptors are
increased by decreased levels of intracellular cholesterol. J. Cell Biol. 107:212A
23.
Talavera, F. and Chew, B.P. 1987. In vitro interaction of lipoproteins with retinol, retinoic acid
and -carotene on progesterone secretion by bovine luteal cells. J. Dairy Sci. (Suppl.1) 70:225
24.
Talavera, F. and Chew, B.P. 1987. Retinol, retinoic acid and -carotene ratios in progesterone
secretion by bovine luteal cells. J. Dairy Sci. (Suppl.1) 70:119
25.
Talavera, F. and Chew, B.P. 1986. Retinol, retinoic acid and -carotene stimulate steroidogenesis
in porcine corpora lutea in vitro. J. Anim. Sci. (Suppl.1) 63:351
26.
Williams, G.L., Petersen, B.J., Talavera, F., Kirsch, J.D., Tilton, J.E. 1985. Divergent control of
follicle-stimulating hormone and luteinizing hormone secretion in the cow revealed by
alterations in physiologic status. Society for the Study of Reproduction
27.
Talavera, F., Kirsch, J.D., Park, C.S., Williams, G.L. 1983. Associated changes in total
cholesterol and ovarian steroid hormones in serum of heifers during the estrous cycle and
following increased dietary lipid. J. Anim. Sci. (Suppl.1) 57:376
28.
Williams, G.L., Talavera, F., Kirsch, J.D., Tilton, J.E. 1983. Suckling and low-level progesterone
stimulation affect coincident secretion of follicle-stimulating hormone and luteinizing hormone
in postpartum beef cows. J. Anim. Sci. (Suppl.1) 57:107
29.
Williams, G.L., Talavera, F., Petersen, B.J., Kirsch, J.D., Tilton, J.E. 1983. Effects of suckling
and low-level progesterone-stimulation on acute release patterns of follicle stimulating hormone
and luteinizing hormone in postpartum beef cows. Anim. Sci. Res. Rep. p.58
30.
Williams, G.L., Talavera, F., Petersen, B.J., Olson, D.K., Tilton, J.E. 1982. Effect of suckling on
hypothalamo-pituitary function of beef cows. Anim. Sci. Res. Rep. p.99