BioCell Collagen™
BioCell Collagen is a science based, clinically tested dietary ingredient that promotes
active joints, youthful looking skin, and healthy connective tissues. Unlike other collagen and
hyaluronic acid ingredients on the market, BioCell Collagen contains a patented composition of
naturally occurring hydrolyzed collagen type II, chondroitin sulfate, and hyaluronic acid in a
highly absorbable matrix form that has been the subject of numerous human clinical trials
including safety, efficacy, and bioavailability.
BioCell Collagen utilizes a patented Bio-Optimization™ process which ensures
remarkable bioavailability as well as rapid absorption into the body. More than 20 clinical
studies including five human clinical trials on BioCell Collagen support its effectiveness and
safety in promoting joint health and skin beauty.
Stimulation of cartilage chondrocytes by hydrolyzed collagen type II
BioCell Collagen is not only bioavailable, it’s also biologically active. Residing
exclusively in the cartilage, the chondrocytes are responsible for the biosynthesis of collagen
type II, HA, and chondroitin sulfate. Hydrolyzed collagen type II contained in BioCell Collagen
has been shown to stimulate these cells to synthesize new collagen type II, suggesting that
BioCell Collagen may help in the regeneration of degraded cartilage.
Highly bioavailable Hyaluronic Acid essential for joint lubrication
In the village of Yuzurihara, Japan (also known as “village of long life”), there seems
to exist a population that has the longest age span in the world. Featured on ABC television, this
village had one common thread—maintenance of hyaluronic acid(HA) levels in their bodies. The
people of this village were living to old ages without wrinkles and common age-related diseases.
In fact, Bill Sardi, author of the new book, HA: How to Live 100 Years without Growing Old
discusses this very phenomenon. HA and collagen have been studied by scientists for over 40
years. It is a key component to many normal bodily functions and has hundreds of research
studies showing its value in skin and joint health. It is a scientific fact that HA and
collagen break down as we age. By age 50 research has shown that the amount of HA is reduced
by 50% in the body.
Hyaluronic Acid (HA) is found in virtually all tissues of the body. In the joint, HA plays
two important roles. First, it acts as a key structural molecule to form healthy, functional
cartilage. Second, HA is a major component of synovial fluid, the lubricant found in our joints
that allows smooth and easy movement. A study showed that consumption of BioCell Collagen
(1500mg/day) led to a 60 times increase in HA levels at steady state. Hyaluronic Acid (HA) is
also a key component of the skin’s extracellular matrix responsible for keeping the skin supple
and hydrated. Studies show that BioCell Collagen helps maintain healthy levels of HA not only
by elevating HA levels in the bloodstream but by inhibiting HA degradation via the enzyme
hyaluronidase
Increase in HA Levels
Inhibition of HA degradation
Clinical Trials
1. BioCell Collagen™ on joint discomfort
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This randomized, double-blind, and placebo-controlled trial enrolled 16 subjects who had
joint discomfort.
The safety and efficacy of BioCell Collagen in managing joint discomfort was
investigated by using the WOMAC index.
The subjects ingested 2 grams daily of BioCell Collagen for 8 weeks.
o As compared to placebo, BioCell Collagen significantly reduced the joint
discomfort as much as 40% at the end of the study.
o No adverse events associated with BioCell Collagen were reported.
The study details were presented at the international conference of Experimental Biology,
2004, Washington, DC.
2. BioCell Collagen™ on joint discomfort – expanded, confirmatory clinical trial
Effect of the novel low molecular weight hydrolyzed chicken sternal cartilage extract,
BioCell Collagen, on improving osteoarthritis-related symptoms: a randomized, doubleblind, placebo-controlled trial.
J Agric Food Chem. 2012 Apr 25;60(16):4096-101. doi: 10.1021/jf205295u. Epub 2012
Apr 16.
Schauss AG1, Stenehjem J, Park J, Endres JR, Clewell A.
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This randomized, double-blind, and placebo-controlled trial enrolled 80 subjects who had
joint discomfort.
The safety and efficacy of BioCell Collagen in managing joint discomfort was
investigated by using the WOMAC index.
The subjects ingested 2 grams daily of BioCell Collagen for 10 weeks.
o As compared to placebo, BioCell Collagen significantly reduced joint discomfort,
confirming the earlier trial discussed above.
o No adverse events associated with BioCell Collagen were reported.
The study outcome was published in Journal of Agricultural and Food Chemistry (2012).
Results of study – Min. 30% less discomfort in 71% of subjects taking BioCell Collagen
3. BioCell Collagen™ on natural and photoaging process in facial skin
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This study enrolled 26 subjects who were undergoing both natural (chronological) and
photo aging process in their face.
Both qualitative and quantitative tools were used to measure visible parameters such as
wrinkles and fine lines and internal parameters such as dermal collagen content,
hydration, and blood microcirculation.
The subjects ingested 1 gram daily of BioCell Collagen for 12 weeks.
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BioCell Collagen demonstrated the following multi-layered mechanisms which
counteracted both natural and photoaging signs.
o Significant reduction of facial lines and wrinkles
o Significant reduction of dryness and skin scaling
o Significant increase in collagen content in the skin dermis
No adverse events associated with BioCell Collagen were reported.
The study outcome was published in The Clinical Interventions in Aging (2012).
(http://www.ncbi.nlm.nih.gov/pubmed/22956862)
Link to www.biocellcollagen.com
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Product Safety Laboratories. September 20, 200